Read by QxMD icon Read


Abdullah Ilhan, Umit Yolcu, Emin Oztas, Uzeyir Erdem
PURPOSE: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. METHODS: Eighteen male rats were divided into the following 4 groups: NM, NM + PAC, NM + CoQ10, and control. The 3 NM groups received a single dose of NM (0.02 mg/μL) on the right eye to induce ocular injury...
June 2018: Arquivos Brasileiros de Oftalmologia
Ying Chen, Jian Zhang, Zhe Chen, Quanguang Wang, Bing Li, Rujing Lai, Xuzhong Xu, Zhifang Cao, Lizhen Yu
BACKGROUND AND OBJECTIVES: Although intravenous lipid emulsion has been proved a powerful antidote for local anesthetic toxicity, there are few pharmacokinetic data on using lipid infusion as a pretreatment for other clinical applications. We assessed the influence of lipid pretreatment on the pharmacodynamics and pharmacokinetics of levobupivacaine. METHODS: Altogether, 12 patients undergoing below-knee surgery for a fracture were randomly assigned to 2 groups (6 patients per group): pretreatment with 1...
June 19, 2018: Regional Anesthesia and Pain Medicine
Young Gi Min, Seung Ho Ham, Yoon Seok Jung, Sangchun Choi
In recent years, various kinds of non-indigenous snakes have become popular as domestic pets globally. If the snake is highly venomous, this would be a potentially life-threatening emergency for breeders. In such a case, the specific antidote should be administered immediately for saving the life. "Salmusa" genus (e.g. Gloydius genus) is a representative indigenous venomous snake in South Korea. Therefore, only one antidote for the "Salmusa" genus is commercially available in South Korea...
June 2018: Turkish Journal of Emergency Medicine
Huan Wang, Ze Zhao, Yuxiao Liu, Changmin Shao, Feika Bian, Yuanjin Zhao
Mimicking subcellular compartments containing enzymes in organisms is considered a promising approach to substitute for missing or lost cellular functions. Inspired by the multicompartment structures of cellular architectures, we present a novel multienzyme system based on hollow hydrogel microcapsules with flexible enzymatic inverse opal particles. Benefiting from the precise operation capability of the microfluidic electrospray and the remarkable structural color marks in the inverse opal particles, we developed a multienzyme system with controllable number, type, and spatial arrangement of the encapsulated enzymes...
June 2018: Science Advances
Masaki Yamawaki, Masato Ohnishi, Shenghong Ju, Junichiro Shiomi
Materials development often confronts a dilemma as it needs to satisfy multifunctional, often conflicting, demands. For example, thermoelectric conversion requires high electrical conductivity, a high Seebeck coefficient, and low thermal conductivity, despite the fact that these three properties are normally closely correlated. Nanostructuring techniques have been shown to break the correlations to some extent; however, optimal design has been a major challenge due to the extraordinarily large degrees of freedom in the structures...
June 2018: Science Advances
(no author information available yet)
No abstract text is available yet for this article.
June 18, 2018: Medical Letter on Drugs and Therapeutics
Fatma Erden, Erol Rauf Agis, Meside Gunduzoz, Omer Hinc Yilmaz
Background Fixed drug eruptions (FDE) are characterized by recurrent, usually solitary erythematous or dark red macular, plaque or bullous lesions, all at the same site. Among the first choices for antidotal treatment in mercury exposure, 2,3-dimercapto-1-propanesulfonic acid (DMPS) is generally a drug with a low incidence of side effects. FDE due to DMPS was not detected in our literature research and so we aimed to present this rare case. Case Report Forty-eight-year-old male patient, gunpowder and explosives factory worker, was admitted to our hospital because of mercury exposure and we started DMPS treatment...
June 18, 2018: Acta Clinica Belgica
Ashima Saxena, Tatyana Belinskaya, Lawrence M Schopfer, Oksana Lockridge
Human butyrylcholinesterase (HuBChE) is under development for use as a pretreatment antidote against nerve agent toxicity. Animals are used to evaluate the efficacy of HuBChE for protection against organophosphorus nerve agents. Pharmacokinetic studies of HuBChE in minipigs showed a mean residence time of 267 h, similar to the half-life of HuBChE in humans, suggesting a high degree of similarity between BChE from 2 sources. Our aim was to compare the biochemical properties of PoBChE purified from porcine milk to HuBChE purified from human plasma...
June 14, 2018: Archives of Biochemistry and Biophysics
Rolando A G Garcia, Joel A Saydoff, Michael K Bamat, Reid W von Borstel
Uridine triacetate has been shown to be an effective antidote against mortality and toxicity caused by either overdoses or exaggerated susceptibility to the widely used anticancer agents 5-fluorouracil (5-FU) and capecitabine. However, a direct assessment of efficacy based on when emergency treatment was initiated was not clinically feasible. In this study we used mouse models of 5-FU overdose and of dihydropyrimidine dehydrogenase (DPD) deficiency to compare the efficacy of uridine triacetate in reducing toxicity and mortality when treatment was initiated at time points from 4 to 144 h after administration of 5-FU...
June 13, 2018: Toxicology and Applied Pharmacology
Johan L Å Nilsson, Anders Blomgren, Ulf J Nilsson, Edward D Högestätt, Lars Grundemar
Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N-acetyl-p-benzoquinone imine (NAPQI) and p-benzoquinone (p-BQ). Herein, the chelating agent, N,N'-Bis(2-mercaptoethyl)isophthalamide (NBMI), was examined for its potential ability to entrap NAPQI and p-BQ and to prevent paracetamol-induced liver injury. Both NBMI and the conventional paracetamol antidote N-Acetyl cysteine (NAC) were investigated with regard to their abilities to scavenge the NAPQI and p-BQ in a Transient Receptor Potential Ankyrin 1 (TRPA1)-dependent screening assay...
June 16, 2018: Basic & Clinical Pharmacology & Toxicology
Justin M Choi, Valerie Bourassa, Kevin Hong, Michael Shoga, Elizabeth Lim, Andrew Park, Kazim Apaydin, Andrew K Udit
The potential applications for nanomaterials continue to grow as new materials are developed and environmental and safety concerns are more adequately addressed. Virus-like particles (VLPs) in particular have myriad applications in medicine and biology, exploiting both the reliable, symmetric self-assembly mechanism and the ability to take advantage of surface functionalities that may be appropriately modified through mutation or bioconjugation. Herein we describe the design and application of hybrid VLPs for use as potent heparin antagonists, providing an alternative to the toxic heparin antidote protamine...
June 14, 2018: Molecular Pharmaceutics
Marcee E Wilder, Lynne D Richardson, Robert S Hoffman, Gary Winkel, Alex F Manini
OBJECTIVES: Racial and ethnic disparities in the United States continue to exist in many disciplines of medicine, extending to care in the Emergency Department (ED). We sought to examine the relationship between patient race/ethnicity and use of either antidotal therapy or gastrointestinal decontamination for individuals presenting to the ED for acute drug overdose. METHODS: We completed a secondary analysis of a prospective cohort of patients with suspected acute overdose presenting to two urban tertiary care hospitals between 2009 and 2014...
June 12, 2018: Clinical Toxicology
F Spizzo, L Del Bianco, M Coïsson, F Chinni, V Mattarello, C Maurizio, G Mattei
We studied (i) a set of three Co : Au continuous films, grown by sputtering co-deposition (∼80 nm thick) with concentration ratios of 2 : 1, 1 : 1 and 1 : 0 (i.e., a pure Co film was also included), and (ii) a corresponding set of antidot arrays, produced by nanosphere lithography with the same hexagonal pattern (nominal lattice periodicity ∼520 nm). The samples were investigated by atomic and magnetic force microscopy and SQUID magnetometry. A twofold aim was fulfilled: to gain information on the magnetism of the CoAu compound (saturation magnetization, effective in-plane and out-of-plane anisotropy, exchange stiffness constant and magnetostrictive behavior) and to compare the magnetic behavior of the continuous and patterned samples...
June 12, 2018: Physical Chemistry Chemical Physics: PCCP
Majid Shirdel-Havar, Rouhollah Farghadan
Spin-caloritronic effects in armchair graphene nanoribbons (AGNRs) with various ribbon widths and periodic structural defects in the form of triangular antidots were systematically studied. Our results showed that by engineering defects in AGNRs, one could not only reduce the phononic thermal conductance for enhancing the thermoelectric efficiency, but also induce a ferromagnetic ground state. Interestingly, AGNRs with triangular antidots exhibit spin-semiconducting behavior with a tunable spin gap and a narrow spin-polarized band around the Fermi level...
June 12, 2018: Physical Chemistry Chemical Physics: PCCP
Kirushanthi Sakthithasan, Pierre Lévy, Joël Poupon, Robert Garnier
BACKGROUND: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa2 EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. METHODS: Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2 EDTA lead mobilization were randomized to receive 1050 mg/m2 /day of oral DMSA (n = 21) or 500 mg/m2 /day of intravenous CaNa2 EDTA (n = 16) over two five-day courses separated by a 10-day rest period...
June 11, 2018: Clinical Toxicology
Théo Willeman, Raphael Marlu, Holger Böhle, Gilles Francony, Jean-François Jourdil, Xavier Fonrose, Françoise Stanke-Labesque
BACKGROUND: Ticagrelor is a direct and reversible competitive antagonist of the P2Y12 receptor and inhibits platelet activation. Although adverse bleeding is common, fatal intoxication has never been documented. CASE DESCRIPTION: A 47-year-old man died from a severe cerebral hemorrhage secondary to a fall and cranial trauma 4 d after the massive intake of ticagrelor. Iterative platelet transfusions did not improve his condition. Toxicological analyses by liquid chromatography tandem mass spectrometry (LC-MS/MS) revealed high plasma concentrations of ticagrelor (3343 µg/L) and its active metabolite AR-C124910XX (656 µg/L) 10 h after intake...
June 11, 2018: Clinical Toxicology
Xiaowen Yu, Zhigang Zhao, Xiaoming Zheng, Jiawu Zhou, Weiyi Kong, Peiran Wang, Wenting Bai, Hai Zheng, Huan Zhang, Jing Li, Jiafan Liu, Qiming Wang, Long Zhang, Kai Liu, Yang Yu, Xiuping Guo, Jiulin Wang, Qibing Lin, Fuqing Wu, Yulong Ren, Shanshan Zhu, Xin Zhang, Zhijun Cheng, Cailin Lei, Shijia Liu, Xi Liu, Yunlu Tian, Ling Jiang, Song Ge, Chuanyin Wu, Dayun Tao, Haiyang Wang, Jianmin Wan
Selfish genetic elements are pervasive in eukaryote genomes, but their role remains controversial. We show that qHMS7 , a major quantitative genetic locus for hybrid male sterility between wild rice ( Oryza meridionalis ) and Asian cultivated rice ( O. sativa ), contains two tightly linked genes [ Open Reading Frame 2 ( ORF2 ) and ORF3 ]. ORF2 encodes a toxic genetic element that aborts pollen in a sporophytic manner, whereas ORF3 encodes an antidote that protects pollen in a gametophytic manner. Pollens lacking ORF3 are selectively eliminated, leading to segregation distortion in the progeny...
June 8, 2018: Science
Mark C Moffett, John H McDonough, Joseph D McMonagle, Todd M Myers
Oxime reactivators are critical antidotes after organophosphate pesticide or nerve agent poisoning, directly restoring the function of inhibited acetylcholinesterase. In the continuing search for more broad-spectrum acetylcholinesterase reactivators, this study evaluated one of the leading next-generation oxime reactivators: methoxime, (1,1'-trimethylene bis[4-(hydroxyimino)methyl]pyridinium dichloride (MMB-4). The pharmacokinetics of both salts of MMB-4 (dichloride [2Cl] and dimethanesulphonate [DMS]) were characterized across a range of relevant doses (19, 58, and 116 µmol/kg, intramuscular) in a nonhuman primate model (male African green monkeys), and only subtle differences were observed between the salts...
January 1, 2018: International Journal of Toxicology
Patrick Y Sips, Xu Shi, Gabriel Musso, Anjali K Nath, Yanbin Zhao, Jason Nielson, Jordan Morningstar, Amy E Kelly, Brittney Mikell, Eva Buys, Vikhyat Bebarta, Jared Rutter, V Jo Davisson, Sari Mahon, Matthew Brenner, Gerry R Boss, Randall T Peterson, Robert E Gerszten, Calum A MacRae
Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures. We have created a pipeline that combines high-throughput screening in zebrafish with subsequent validation in two mammalian small animal models as well as a porcine large animal model. We found that zebrafish embryos in the first 3 days post fertilization (dpf) are highly resistant to cyanide, becoming progressively more sensitive thereafter...
2018: PloS One
Máté Pásztor, Dániel Bereczki, Zoltán Szakács, Zsolt May
Introduction - Expanding indications have resulted in an increasing number of patients taking novel oral anticoagulants, posing a major treatment dilemma in acute ischemic stroke. Case presentation - We present a successful intravenous thrombolysis in a dabigatran-treated patient with acute ischemic stroke after the administration of idarucizumab. Discussion - According to current guidelines, systemic thrombolysis is contraindicated under treatment with novel oral anticoagulants (taken within 48 hours). In this scenario, idarucizumab offers a solution by reversing the anticoagulant effect of dabigatran...
July 30, 2017: Ideggyógyászati Szemle
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"