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https://www.readbyqxmd.com/read/29456085/what-is-the-role-of-reversal-agents-in-the-management-of-emergency-department-patients-with-dabigatran-associated-hemorrhage
#1
Bryan D Hayes, Michael E Winters, Steve B Rosenbaum, Mohannad F Allehyani, Gary M Vilke
BACKGROUND: In 2010, the U.S. Food and Drug Administration (FDA) approved dabigatran as the first non-warfarin oral anticoagulant for use in the United States. At the time of FDA approval, there was no antidote or effective treatment for dabigatran-induced hemorrhage. In 2015, the FDA approved idarucizumab for the treatment of dabigatran-induced hemorrhage. The purpose of this clinical practice statement is to evaluate the role of select reversal agents in the management of patients with dabigatran-associated bleeding...
February 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29452113/technological-innovation-strategies-for-the-specific-treatment-of-chagas-disease-based-on-benznidazole
#2
REVIEW
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves, Débora Dolores Souza da Silva Nascimento, Isabela Araújo E Amariz, Aline Silva Ferreira, Salvana Priscylla Manso Costa, Larissa Araújo Rolim, Ádley Antonini Neves de Lima, Pedro José Rolim Neto
Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market for treating the disease...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451035/revisiting-the-physiological-effects-of-methylene-blue-as-a-treatment-of-cyanide-intoxication
#3
Philippe Haouzi, Maxime Gueguinou, Takashi Sonobe, Annick Judenherc-Haouzi, Nicole Tubbs, Mohamed Trebak, Joseph Cheung, Frederic Bouillaud
BACKGROUND: Although methylene blue (MB) had long been proposed to counteract the effects of cyanide (CN) intoxication, research on its mechanisms of action and efficacy has been abandoned for decades. Recent studies on the benefits of MB in post-anoxic injuries have prompted us to reexamine the relevance of this historical observation. METHODS: Our study was performed in adult male Sprague-Dawley rats and on HEK293T epithelial cells. First, the effects and toxicity of MB (0-80 mg/kg) on circulation and metabolism were established in four urethane-anesthetized rats...
February 16, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29439874/metahemoglobinemia-in-infants-over-one-year
#4
José Miguel Martínez de Zabarte Fernández, Juan Pablo García Íñiguez, Mercedes Domínguez Cajal
BACKGROUND AND OBJECTIVES: Methaemoglobinaemia is a typical acute intoxication disorder in children under one year old. It is produced by excess nitrates which induce the haemoglobin's iron oxidation, preventing its adequate binding to oxygen. It is more frequent in infants due to its lower enzymatic activity. PATIENTS: Two cases of 15-month-old infants with methaemoglobinaemia after the intake of vegetables, atypical by the age of the patients and the initial severity in the first case that simulated a septic syndrome...
February 10, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29431167/potential-and-pitfalls-of-email-control-as-a-burnout-antidote
#5
EDITORIAL
Saty Satya-Murti, Allison L Weathers
No abstract text is available yet for this article.
December 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29427266/correction-to-acmt-position-statement-addressing-the-rising-cost-of-prescription-antidotes
#6
Maryann Mazer-Amirshahi, Andrew Stolbach, Lewis S Nelson
This article contains a couple typographical errors in the table and in the formatting of references. The authors and the journal apologize for those errors and respectfully include a corrected table and corrected reference list here.
February 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29425981/spontaneous-cervical-spinal-epidural-hematoma-associated-with-dabigatran-a-case-report
#7
Quentin Mathais, Pierre Esnault, Maximilien Cruc, Cedric Bernard, Bertrand Prunet, Pierre Emmanuel Gaillard
BACKGROUND: While spontaneous spinal epidural hematomas are rare, one of the identified risk factors is vitamin K antagonist therapy. CASE DESCRIPTION: We present a case of a spontaneous spinal epidural hematoma occurring in a patient under treatment with dabigatran, a non-vitamin K oral anticoagulant. The initial hemiparesis symptom was misleading and was retrospectively identified as Brown Sequard syndrome. Immediate dabigatran antagonism with idarucizumab followed by posterior cervical laminectomy permitted a complete neurological recovery at day 4...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29421945/cytotoxicity-of-acetylcholinesterase-reactivators-evaluated-in-vitro-and-its-relation-to-their-structure
#8
Lubica Muckova, Jaroslav Pejchal, Petr Jost, Nela Vanova, David Herman, Daniel Jun
The development of acetylcholinesterase reactivators, i.e., antidotes against organophosphorus poisoning, is an important goal of defense research. The aim of this study was to compare cytotoxicity and chemical structure of five currently available oximes (pralidoxime, trimedoxime, obidoxime, methoxime, and asoxime) together with four perspective oximes from K-series (K027, K074, K075, and K203). The cytotoxicity of tested substances was measured using two methods - colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and impedance based real-time cytotoxicity assay - in three different cell lines (HepG2, ACHN, and NHLF)...
February 9, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29417853/challenges-in-the-diagnosis-of-acute-cyanide-poisoning
#9
J L Parker-Cote, J Rizer, J P Vakkalanka, S V Rege, C P Holstege
OBJECTIVE: The aim of this systematic review was to identify isolated acute cyanide poison cases and to identify reported signs, symptoms, and laboratory findings. METHODS: We searched MEDLINE, Cochrane Reviews, and Web of Science case reports and series using a number of MeSH descriptors pertaining to cyanide, toxicity, and poisonings. We excluded studies on plants, laboratory analyses, smoke inhalation poisonings, animals as well as non-English language articles and those in which data were not available...
February 8, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29417032/paraquat-poisoning-case-report-of-a-survivor
#10
M Asisha Janeela, Ajoy Oommen, Ajay Kumar Misra, I Ramya
N, N'-dimethyl-4, 4'-bipyridinium dichloride (paraquat) is a widely used synthetic, nonselective contact herbicide. Ingestion of toxic doses of paraquat can be fatal with life-threatening effects on the lungs, gastrointestinal (GI) tract, kidney, liver, heart, and other organs. Till date, there are no specific antidotes and none of the current treatments have proven efficacious. The prognosis is uniformly poor worldwide, including those who treat aggressively with multimodal therapies. Long-term survivors are few, and have GI and pulmonary complications...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29416443/low-energy-bluetooth-for-detecting-real-world-penetrance-of-bystander-naloxone-kits-a-pilot-study
#11
Jeffrey T Lai, Brittany P Chapman, Katherine L Boyle, Edward W Boyer, Peter R Chai
Opioid overdose is a growing public health emergency in the United States. The antidote naloxone must be administered rapidly after opioid overdose to prevent death. Bystander or "take-home" naloxone programs distribute naloxone to opioid users and other community members to increase naloxone availability at the time of overdose. However, data describing the natural history of take-home naloxone in the hands of at-risk individuals is lacking. To understand patterns of naloxone uptake in at-risk users, we developed a smart naloxone kit that uses low-energy Bluetooth (BLE) to unobtrusively detect the transit of naloxone through a hospital campus...
January 3, 2018: Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences
https://www.readbyqxmd.com/read/29413611/rationally-designed-magnetic-nanoparticles-as-anticoagulants-for-blood-purification
#12
Weifeng Zhao, Qiang Liu, Xiang Zhang, Baihai Su, Changsheng Zhao
Heparin-based anticoagulant drugs are widely used for the prevention of blood clotting during extracorporeal circuit (bloodlines or cassette system) and surgical procedures as well as for the treatment of thromboembolic events. However, these anticoagulants are associated with bleeding risks that demand continuous monitoring and neutralization with antidotes. We explore the possibility of utilizing anticoagulants for blood clotting prevention, then removing them before transfusing the blood back to body, thus avoid bleeding risks...
February 2, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29407839/humic-acid-alleviates-the-ecotoxicity-of-graphene-family-materials-on-the-freshwater-microalgae-scenedesmus-obliquus
#13
Ying Zhang, Tiantian Meng, Xi Guo, Ruixin Yang, Xiaohui Si, Jiti Zhou
The extensive application of graphene-family materials (GFMs) has increased its potential risk to aquatic organisms. However, the influence of humic acid (HA) on the biotoxicity of GFMs has not clarified. Here, we conduct a study on the toxicity of four GFMs, i.e. graphene (G), graphene oxide (GO), carboxyl-modified graphene (G-COOH) and amine-modified graphene (G-NH2), with or without HA, using Scenedesmus obliquus (S. obliquus) as model organism. Our results showed that the four GFMs induced significant inhibition on cell growth and Chlorophyll-a (Chl-a) synthesis, loss of cell viability and membrane integrity as well as mitochondrial membrane potential (MMP), where G exhibited the highest toxicity with median effect concentration (EC50) of 8...
January 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29404633/-bonzai-lead-and-bath-salt-poisoning-with-new-and-old-drugs-synthetic-amphetamines-cathinones-cannabinoids-and-opioids-an-overview
#14
REVIEW
J Strube, A Schaper
BACKGROUND: There has been an increase in the number of serious poisonings and deaths after the use of new psychoactive substances (NPS). These are usually bought online: sometimes legally, often illegally or "in the grey area". OBJECTIVES: Characteristics of different NPS. Legal status concerning the New Psychoactive Substances Act (NpSG). Risk assessment of several substance groups, possible complications of acute poisonings, therapeutic recommendations...
February 5, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29402972/publisher-correction-ballistic-geometric-resistance-resonances-in-a-single-surface-of-a-topological-insulator
#15
Hubert Maier, Johannes Ziegler, Ralf Fischer, Dmitriy Kozlov, Ze Don Kvon, Nikolay Mikhailov, Sergey A Dvoretsky, Dieter Weiss
In the original version of this Article, the second and third sentences of the first paragraph of the "Gate voltage and antidot period dependencies" section of the Results originally incorrectly read "The characteristic evolution of the sheet resistance ρ□=ρ□ (B=0) with Vg shown for three antidot samples and an unpatterned reference sample in Fig. 3a. The maxima of ρxx, located between Vg~0.5 and 1 V, reflect the charge neutrality point (CNP), corresponding to an EF position located slightly in the valence band (see band structure in Fig...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29397554/the-role-of-intralipid-emulsion-in-the-rat-model-of-digoxin-intoxication
#16
Cansu Arslan Turan, Tuba Cimilli Ozturk, Ebru Unal Akoglu, Rohat Ak, Kemal Aygun, Ali Sahiner, Engin Sumer, Adnan Somay, Ozge Ecmel Onur
Although the mechanism of action is not well known, intravenous lipid emulsion (ILE) has been shown to be effective in the treatment of lipophilic drug intoxications. It is thought that, ILE probably separates the lipophilic drugs from target tissue by creating a lipid-rich compartment in the plasma. The second theory is that ILE provides energy to myocardium with high-dose free fatty acids activating the voltage-gated calcium channels in the myocytes. In this study, effects of ILE treatment on digoxin overdose were searched in an animal model in terms of cardiac side effects and survival...
February 3, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29395761/cyanide-poisoning-is-a-possible-cause-of-cardiac-arrest-among-fire-victims-and-empiric-antidote-treatment-may-improve-outcomes
#17
Yasuhiko Kaita, Takehiko Tarui, Takahiro Shoji, Hiroshi Miyauchi, Yoshihiro Yamaguchi
BACKGROUND: Carbon monoxide and cyanide poisoning are important causes of death due to fire. Carbon monoxide is more regularly assessed than cyanide at the site of burn or smoke inhalation treatment due to its ease in assessment and simplicity to treat. Although several forensic studies have demonstrated the significance of cyanide poisoning in fire victims using blood cyanide levels, the association between the cause of cardiac arrest and the concentration of cyanide among fire victims has not been sufficiently investigated...
January 22, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29392100/use-of-n-acetylcysteine-in-psychiatric-conditions-among-children-and-adolescents-a-scoping-review
#18
REVIEW
Sadiq Naveed, Afshan Amray, Ahmed Waqas, Amna M Chaudhary, Muhammad W Azeem
N-acetylcysteine (NAC) is a well-known antidote for acetaminophen toxicity and is easily available over the counter. It has antioxidant and anti-inflammatory properties and an established tolerance and safety profile. Owing to its neuroprotective effects, its clinical use has recently expanded to include the treatment of different psychiatric and non-psychiatric disorders. Although a number of randomized controlled trials have documented the clinical evidence for NAC, there are no reviews that summarize the evidence...
November 29, 2017: Curēus
https://www.readbyqxmd.com/read/29387311/education-as-an-antidote-to-cynicism-a-longitudinal-investigation
#19
Olga Stavrova, Daniel Ehlebracht
Although cynical beliefs about human nature yield numerous adverse consequences for individuals' life outcomes and well-being, very little is known about factors that counteract the development of cynical beliefs. Drawing from the literature on the "education effect" describing the importance of education in overcoming close-mindedness and negative views of others, we propose that education can represent an antidote to cynicism. The results of two large-scale longitudinal studies showed that education was associated with lower levels of cynicism over time spans of 4 and 9 years...
January 2018: Social Psychological and Personality Science
https://www.readbyqxmd.com/read/29378027/phosphine-analysis-in-postmortem-specimens-following-inhalation-of-phosphine-fatal-aluminum-phosphide-poisoning-in-children
#20
Hui Yan, Hang Chen, Zhengdong Li, Min Shen, Xianyi Zhuo, Hejian Wu, Ping Xiang
Phosphine is an insecticide for the fumigation of grains, animal feed, and leaf-stored tobacco, and it was used as a rodenticide in bulk grain stores. Phosphine poisoning may occur after accidental inhalation of phosphine, sometimes leading to death. Analysis of phosphine and its metabolites in postmortem specimens from seven fatal cases was conducted in this study, as well as postmortem specimens collected from rabbits exposed to phosphine. The total phosphine in postmortem specimens was analyzed by headspace gas chromatography coupled with mass spectrometry...
January 25, 2018: Journal of Analytical Toxicology
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