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https://www.readbyqxmd.com/read/28343171/circulating-free-light-chain-measurement-in-the-diagnosis-prognostic-assessment-and-evaluation-of-response-of-al-amyloidosis-comparison-of-freelite-and-n-latex-flc-assays
#1
Giovanni Palladini, Arnaud Jaccard, Paolo Milani, David Lavergne, Andrea Foli, Sebastien Bender, Francesca Lavatelli, Tiziana Bosoni, Veronica Valentini, Laura Pirolini, Giovanni Ferraro, Marco Basset, Francesca Russo, Mario Nuvolone, Riccardo Albertini, Michel Cogne, Giampaolo Merlini
BACKGROUND: The measurement of circulating free light chain (FLC) is essential in the diagnosis, prognostic stratification and evaluation of response to therapy in light chain (AL) amyloidosis. For more than 10 years, this has been done with an immunonephelometric assay based on polyclonal antibodies (Freelite), and cutoffs for staging and response assessment have been validated with this method. Recently, a new assay based on monoclonal antibodies (N latex FLC) has been marketed in Europe...
March 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28342354/integrated-ion-imprinted-polymers-paper-composites-for-selective-and-sensitive-detection-of-cd-ii-ions
#2
Kai Huang, Ying Chen, Feng Zhou, Xiaoya Zhao, Jiafa Liu, Surong Mei, Yikai Zhou, Tao Jing
Paper-based sensor is a new alternative technology to develop a portable, low-cost, and rapid analysis system in environmental chemistry. In this study, ion imprinted polymers (IIPs) using cadmium ions as the template were directly grafted on the surface of low-cost print paper based on the reversible addition-fragmentation chain transfer polymerization. It can be applied as a recognition element to selectively capture the target ions in the complex samples. The maximum adsorption capacity of IIPs composites was 155...
March 18, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340397/quantification-of-hydrocarbon-species-on-surfaces-by-combined-microbalance-ftir
#3
Andrew I McNab, Tom Heinze, Alan J McCue, Davide Dionisi, James A Anderson
Absorption coefficients for the asymmetric stretching modes of CH3 and CH2 groups formed by adsorbing alkyl chained species from the vapour phase onto two different adsorbents; a γ-alumina support material and a supported metal catalyst have been determined using a custom made thermogravimetric-infrared cell. Results show that despite variations in the individually calculated absorption coefficients (ca. ±20%), the ratio of the absorption coefficients (CH2:CH3) remained consistent despite employing adsorbates of varying chain length and functionality, and despite the choice of adsorbents which exhibited different surface areas and light scattering characteristics...
March 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28339909/il-17-and-cd40-ligand-synergistically-stimulate-the-chronicity-of-diabetic-nephropathy
#4
Huey-Liang Kuo, Chiu-Ching Huang, Tze-Yi Lin, Ching-Yuang Lin
Background.: Early stages of diabetic nephropathy (DN) are characterized by an influx of inflammatory cells. Interactions between infiltrating T cells and podocytes may play an important role in the ongoing inflammatory response and remodelling. The aim of this study was to explore the role of IL-17 and CD40 ligand (CD40L) in DN. Methods.: The study design involved a case series. Kidney biopsy samples of 69 patients with type 2 diabetes were assessed for the presence of CD4 +  IL-17 +  T cells...
March 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339048/agr2-ameliorates-tumor-necrosis-factor-%C3%AE-induced-epithelial-barrier-dysfunction-via-suppression-of-nf-%C3%AE%C2%BAb-p65-mediated-mlck-p-mlc-pathway-activation
#5
Xiaolin Ye, Mei Sun
Intestinal epithelial barrier dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Anterior gradient protein 2 homologue (AGR2) assists in maintaining intestinal homeostasis in dextran sulphate sodium-induced mouse ileocolitis; however, it is unclear whether it modulates intestinal barrier function. Our study aimed to investigate the protective role of AGR2 in tumor necrosis factor (TNF)-α-induced intestinal epithelial barrier injury. Caco-2 cell monolayers were pre-transfected with an AGR2 plasmid and then exposed to TNF-α...
March 21, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28339018/role-of-autophagy-in-the-progression-of-osteoarthritis-the-autophagy-inhibitor-3-methyladenine-aggravates-the-severity-of-experimental-osteoarthritis
#6
Ni-Tao Cheng, Hai Meng, Li-Feng Ma, Liang Zhang, Hao-Miao Yu, Zhen-Zhong Wang, Ai Guo
Accumulating evidence suggests that autophagy is closely related to the pathogenesis of osteoarthritis (OA). The aim of this study was to determine the changes in autophagy during the progression of OA and to elucidate the specific role of autophagy in OA. For this purpose, a cellular model of OA was generated by stimulating SW1353 cells with interleukin (IL)-1β and a rabbit model of OA was also established by an intra-articular injection of collagenase, followed by treatment with the autophagy specific inhibitor, 3-methyladenine (3-MA)...
March 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28338670/encouraging-impact-of-doxycycline-on-early-mortality-in-cardiac-light-chain-al-amyloidosis
#7
A D Wechalekar, C Whelan
No abstract text is available yet for this article.
March 24, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28338619/role-and-function-of-a2a-and-a%C3%A2-adenosine-receptors-in-patients-with-ankylosing-spondylitis-psoriatic-arthritis-and-rheumatoid-arthritis
#8
Annalisa Ravani, Fabrizio Vincenzi, Alessandra Bortoluzzi, Melissa Padovan, Silvia Pasquini, Stefania Gessi, Stefania Merighi, Pier Andrea Borea, Marcello Govoni, Katia Varani
Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are chronic inflammatory rheumatic diseases that affect joints, causing debilitating pain and disability. Adenosine receptors (ARs) play a key role in the mechanism of inflammation, and the activation of A2A and A₃AR subtypes is often associated with a reduction of the inflammatory status. The aim of this study was to investigate the involvement of ARs in patients suffering from early-RA (ERA), RA, AS and PsA. Messenger RNA (mRNA) analysis and saturation binding experiments indicated an upregulation of A2A and A₃ARs in lymphocytes obtained from patients when compared with healthy subjects...
March 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28338415/hyaluronic-acid-hydrogel-functionalized-with-self-assembled-micelles-of-amphiphilic-pegylated-kartogenin-for-the-treatment-of-osteoarthritis
#9
Mi-Lan Kang, Se-Young Jeong, Gun-Il Im
Synthetic hyaluronic acid (HA) containing a covalently integrated drug is capable of releasing therapeutic molecules and is an attractive candidate for the intra-articular treatment of osteoarthritis (OA). Herein, self-assembled PEGylated kartogenin (PEG/KGN) micelles consisting of hydrophilic polyethylene glycol (PEG) and hydrophobic KGN, which has been shown to induce chondrogenesis in human mesenchymal stem cells, were prepared by covalent crosslinking. HA hydrogels containing PEG/KGN micelles (HA/PEG/KGN) were prepared by covalently bonding PEG chains to HA...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28338391/modifications-in-human-oral-fibroblast-ultrastructure-collagen-production-and-lysosomal-compartment-in-response-to-e-cigarette-fluids
#10
Silvia Sancilio, Marialucia Gallorini, Amelia Cataldi, Laura Sancillo, Rosa Alba Rana, Viviana di Giacomo
Background Many smokers have recently turned to electronic cigarettes (e-cigarettes) because they have been marketed as a cheaper and safer smokeless alternative to traditional cigarettes, and a possible smoking cessation tool. Even though the safety of these electronic devices is still not fully known, there is evidence of their cytotoxicity on cells which belong to the oral cavity. In a previous paper the increase of reactive oxygen production and Bax expression, followed by the occurrence of apoptosis, were demonstrated in human gingival fibroblasts...
March 24, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28338244/photoalignment-of-vertically-oriented-microphase-separated-lamellae-in-lc-lc-diblock-copolymer-thin-film
#11
Koichiro Beppu, Yuki Nagashima, Mituo Hara, Shusaku Nagano, Takahiro Seki
The microphase separation and photoalignment behavior of a diblock copolymer consisting of two kinds of side chain liquid crystalline (LC) polymers are investigated. Here, the mesogens of photoresponsive azobenzene and non-photoresponsive cyanobiphenyl are introduced in the side chains. The azobenzene and cyanobiphenyl mesogens orient homeotropically and planarly, respectively, in a thin film state. The combination of these contrasting orienting properties leads to a formation of vertically oriented lamella in the microphase separation structure...
March 24, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28338217/fasting-up-regulates-ferroportin-1-expression-via-a-ghrelin-ghsr-mapk-signaling-pathway
#12
Qian-Qian Lou, Yu-Fu Zhou, Mesona Yung-Jin Chen, Li Liu, Juan Ma, Meng-Wan Zhang, Fa-Li Zhang, Ya Ke, Zhong-Ming Qian
The significant positive correlation between ghrelin and iron and hepcidin levels in the plasma of children with iron deficiency anemia prompted us to hypothesize that ghrelin may affect iron metabolism. Here, we investigated the effects of fasting or ghrelin on the expression of hepcidin, ferroportin 1 (Fpn1), transferrin receptor 1 (TfR1), ferritin light chain (Ft-L) proteins and ghrelin, and also hormone secretagogue receptor 1 alpha (GHSR1α) and ghrelin O-acyltransferase (GOAT) mRNAs in the spleen and/or macrophage...
March 24, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28337476/cerebrospinal-fluid-biomarker-examination-as-a-tool-to-discriminate-behavioral-variant-frontotemporal-dementia-from-primary-psychiatric%C3%A2-disorders
#13
Everard G B Vijverberg, Annemiek Dols, Welmoed A Krudop, Marta Del Campo Milan, Cora J Kerssens, Flora Gossink, Niels D Prins, Max L Stek, Philip Scheltens, Charlotte E Teunissen, Yolande A L Pijnenburg
INTRODUCTION: To prospectively determine the diagnostic value of cerebrospinal fluid (CSF) levels total-tau (tau) to amyloid-β1-42 ratio (Aβ1-42) ratio (tau/Aβ1-42 ratio), phosphorylated-tau (p-tau) to tau ratio (p-tau/tau ratio), neurofilament light chain (NfL) and YKL40 in the late-onset frontal lobe syndrome, in particular for the differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) versus primary psychiatric disorders (PSY). METHOD: We included patients with a multidisciplinary 2-year-follow-up diagnosis of probable/definite bvFTD (n = 22) or PSY (n = 25), who underwent a detailed neuropsychiatric clinical examination, neuropsychological test battery, and magnetic resonance imaging at baseline...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28336182/light-chain-amyloidosis-where-are-the-light-chains-from-and-how-they-play-their-pathogenic-role
#14
REVIEW
Chunlan Zhang, Xufei Huang, Jian Li
Amyloid light-chain (AL) amyloidosis is a plasma-cell dyscrasia, as well as the most common type of systematic amyloidosis. Pathogenic plasma cells that have distinct cytogenetic and molecular properties secrete an excess amount of amyloidogenic light chains. Assisted by post-translational modifications, matrix components, and other environmental factors, these light chains undergo a conformational change that triggers the formation of amyloid fibrils that overrides the extracellular protein quality control system...
March 8, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28335387/dectin-1-mediated-pathway-contributes-to-fusarium-proliferatum-induced-cxcl-8-release-from-human-respiratory-epithelial-cells
#15
Chang-Ching Yeh, Huann-Cheng Horng, Hong Chou, Hsiao-Yun Tai, Horng-Der Shen, Shie-Liang Hsieh, Peng-Hui Wang
Fusarium species are causative agents of human respiratory disorders and are distributed widely in our environment. Little is known of their interaction with human respiratory epithelial cells, which may contribute to allergic airway responses. In this study, we report on the release of C-X-C motif chemokine ligand 8 (CXCL-8) from human bronchial epithelial BEAS-2B cells upon stimulation with Fusarium proliferatum extracts. F. proliferatum-induced cytokine release from BEAS-2B cells was determined by cytokine array and CXCL-8 enzyme-linked immunosorbent assay (ELISA) kits...
March 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28334621/sequential-cyclophosphamide-bortezomib-dexamethasone-unmasks-the-harmful-cardiac-effect-of-dexamethasone-in-primary-light-chain-cardiac-amyloidosis
#16
Fabien Le Bras, Valerie Molinier-Frenkel, Aziz Guellich, Jehan Dupuis, Karim Belhadj, Soulef Guendouz, Karima Ayad, Magali Colombat, Nicole Benhaiem, Claire Marie Tissot, Anne Hulin, Arnaud Jaccard, Thibaud Damy
Chemotherapy combining cyclophosphamide, bortezomib and dexamethasone is widely used in light-chain amyloidosis. The benefit is limited in patients with cardiac amyloidosis mainly because of adverse cardiac events. Retrospective analysis of our cohort showed that 39 patients died with 42% during the first month. A new escalation-sequential regimen was set to improve the outcomes. Nine newly-diagnosed patients were prospectively treated with close monitoring of serum N-terminal pro-brain natriuretic peptide, troponin-T and free light chains...
March 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28332691/relaxations-and-phase-transitions-during-the-collapse-of-a-dense-pnipam-microgel-suspension-thorough-insight-using-dielectric-spectroscopy
#17
Man Yang, Chunyan Liu, Yiwei Lian, Kongshuang Zhao, Dan Zhu, Jianfeng Zhou
The dielectric behavior of a thermo-sensitive poly-(N-isopropylacrylamide) (PNIPAM) microgel suspension with a dense concentration was investigated over the frequency range of 40 Hz to 110 MHz in a wide temperature window of 10-60 °C. By successfully removing the electrode polarization effect from the original data, two remarkable and temperature-dependent relaxation processes were observed. Both of the two-phase transition processes, i.e., the colloidal crystal-to-liquid transition, which has not yet been detected by dielectric spectroscopy before, as well as the volume phase transition, were detected by the relaxation parameters...
March 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28332670/high-temperature-structural-phase-transition-coupled-with-dielectric-switching-in-an-organic-inorganic-hybrid-crystal-nh3-ch2-2br-3cdbr5
#18
Hai-Peng Chen, Zhong-Xia Wang, Cheng Chen, Yang Lu, Zi Yin, Xiao-Fen Sun, Da-Wei Fu
Molecular bistable switches (electrical switches "ON" and "OFF") represent a class of highly desirable intelligent materials due to their sensitive switchable responses, simple and environmentally friendly processing, light weight, and mechanical flexibility. In particular, these switches above room temperature with potential practical application are rarely reported. In this work, a new zigzag chained organic-inorganic hybrid compound [NH3(CH2)2Br]3CdBr5 (1), which displays rapidly sensitive dielectric switching reversibility and remarkable switching antifatigue, has been successfully synthesized...
March 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28332561/inertial-bioluminescence-rhythms-at-the-capo-passero-km3net-italia-site-central-mediterranean-sea
#19
J Aguzzi, E Fanelli, T Ciuffardi, A Schirone, J Craig
In the deep sea, the sense of time is dependent on geophysical fluctuations, such as internal tides and atmospheric-related inertial currents, rather than day-night rhythms. Deep-sea neutrino telescopes instrumented with light detecting Photo-Multiplier Tubes (PMT) can be used to describe the synchronization of bioluminescent activity of abyssopelagic organisms with hydrodynamic cycles. PMT readings at 8 different depths (from 3069 to 3349 m) of the NEMO Phase 2 prototype, deployed offshore Capo Passero (Sicily) at the KM3NeT-Italia site, were used to characterize rhythmic bioluminescence patterns in June 2013, in response to water mass movements...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332403/time-resolved-spectroscopic-study-of-the-defluorination-and-cyclization-reactions-of-lomefloxacin-in-water
#20
Tao Su, Ming-De Li, Jiani Ma, David Lee Phillips
The mechanism of the defluorination reaction(s) of lomefloxacin (LF) upon light illumination was investigated by using ultrafast laser flash photolysis combined with transient resonance Raman spectroscopy in near neutral water solution. The zwitterionic configuration of LF was determined to be the main species present in the near neutral water solution and was the species that was photoexcited to initiate the photochemical reaction. Femtosecond transient absorption revealed that the first excited singlet state (S1) of LF did not appreciably undergo intersystem crossing (ISC) and instead partially decayed to the ground state via fluorescence emission and partially underwent the cleavage of the carbon-fluorine bond at position 8 to produce a singlet LF aryl cation intermediate...
March 23, 2017: Journal of Physical Chemistry. B
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