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https://www.readbyqxmd.com/read/29142367/case-of-carcinoma-breast-with-unusually-large-tumor-thrombus-in-superior-vena-cava-detected-on-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan
#1
Arun Sasikumar, Anto Baby, Mathews Jose, Retcy Mary Paul
A 60-year-old female with triple negative breast cancer, postsurgery, neoadjuvant chemotherapy and radiotherapy, on follow-up had facial puffiness and giddiness. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) done for suspected recurrence evaluation revealed a large tumor thrombus (TT) in superior vena cava (SVC) with radiological evidence of SVC obstruction. (18)F-FDG PET/CT also showed evidence of FDG avid brain metastases, lymph nodal metastases, and metastatic soft tissue deposits...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29113957/ecological-observations-and-altered-indigenous-harvesting-practices-of-trillium-govanianum-melanthiaceae-in-indian-himalayas
#2
Harsh K Chauhan, Anil K Bisht, Indra D Bhatt, Arvind Bhatt, David Gallacher, Andrea Santo
ETHANOBOTANICAL RELEVANCE: Trillium govanianum Wall. ex D. Don (Melanthiaceae) is a high value medicinal herb which is used in both Indian and Chinese traditional medicines for various purposes such as treatment of cancer, hypertension, neurasthenia, giddiness, arthritis, dysentery, inflammation, sepsis and reproductive disorders. This species is restricted to specific habitat types, such as shaded, cold, moist habitats. However, the rhizomes of this species which are collected from wild populations have been traded throughout the Himalayan region and recently emerged as a significant source of income among local people of Indian Himalayan region...
November 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28989893/an-intriguing-family-with-type-2-diabetes-mellitus-and-complete-heart-block
#3
Gaurav Agarwal, Satish Kumar Singh
Chronic hyperglycaemia of Type 2 Diabetes Mellitus (T2DM) causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias. A 62 year old male presented to our emergency with complaint of sudden onset giddiness from last 2 hours. This was followed by loss of consciousness. Patient was a known case of T2DM since last 1 year. Family history- patient has two brothers who also have T2DM and both of them also developed Complete Heart Block (CHB) spontaneously...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28979922/clinic-based-urinary-lipoarabinomannan-as-a-biomarker-of-clinical-disease-severity-and-mortality-among-antiretroviral-therapy-naive-human-immunodeficiency-virus-infected-adults-in-south-africa
#4
Paul K Drain, Elena Losina, Sharon M Coleman, Janet Giddy, Douglas Ross, Jeffrey N Katz, Kenneth A Freedberg, Ingrid V Bassett
BACKGROUND: Urinary lipoarabinomannan (LAM) has limited sensitivity for diagnosing active human immunodeficiency virus (HIV)-associated tuberculosis (TB) disease, but LAM screening at HIV diagnosis might identify adults with more severe clinical disease or greater risk of mortality. METHODS: We enrolled antiretroviral therapy-naive HIV-infected adults from 4 clinics in Durban. Nurses performed urine LAM testing using a rapid assay (Determine TB LAM) graded from low (1+) to high (≥3+) intensity...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28972699/ledipasvir-and-sofosbuvir-for-untreated-hcv-genotype-1-infection-in-end-stage-renal-disease-patients-a-prospective-observational-study
#5
Mandarapu Surendra, Sree Bhushan Raju, Nimmagadda Sridhar, Bangillapati Vijay Kiran, Goli Rajesh, Golla Anvesh, Nallagasu Raju
INTRODUCTION: Hepatitis C virus (HCV) infection in end stage renal disease (ESRD) is associated with increased mortality. Recently, numerous directly acting antiviral agents have been approved for the management of HCV. Ledipasvir along with Sofosbuvir has been approved for management of genotype 1 infection in patients with eGFR ≥30 mL/min. However, there is paucity of data regarding its role in the management of patients on dialysis. MATERIAL AND METHODS: This is a single center prospective open label observational study to assess the safety and efficacy of Ledipasvir and Sofosbuvir in hemodialysis (HD) patients who were diagnosed with HCV genotype 1 infection...
October 3, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28874083/azathioprine-induced-pancytopenia-and-septic-complications-a-probable-cause-of-death
#6
Bijoy K Panda, Siddhi Umarje, Arundhati Diwan
Azathioprine, an immunosuppressant which is widely used in the management of the autoimmune neuromuscular disorder. Myasthenia gravis is known to cause myelotoxicity. A 55-year-old male recently diagnosed with myasthenia gravis and chronic kidney disease was put on azathioprine (100 mg/d) along with pyridostigmine and prednisolone. When the treatment was initiated, the hematological reports revealed normal levels of blood count. However, approximately within 3 weeks of continuing the prescribed drugs, the patient was readmitted for complaints of loose watery stools, weakness, and giddiness...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28794532/local-anaesthetic-systemic-toxicity-following-oral-ingestion-in-a-child-revisiting-dibucaine
#7
Raylene Dias, Nandini Dave, Milind S Tullu, Chandrahas T Deshmukh
Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations. Systemic toxicity following oral ingestion of local anaesthetics is rare. We report a case of accidental ingestion of dibucaine (ear drops) in a 7-year-old child who developed diplopia, giddiness, ventricular premature contractions and a right bundle branch block. We also present a brief discussion on the pharmacologic and toxicity profile of dibucaine, the Naranjo algorithm for assessing causality in case of adverse drug reactions and a review of current guidelines on the management of local anaesthetic systemic toxicity...
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28782308/a-prospective-observational-study-to-determine-the-prevalence-and-clinical-profile-of-patients-of-hypertensive-crisis-in-a-tertiary-care-hospital
#8
Santosh B Salagre, Shobha M Itolikar, Kapil Gedam
BACKGROUND: Hypertension can present in crisis form as 'hypertensive urgency'(HU) or as 'hypertensive emergency' (HE). Both the conditions are associated with significant morbidity and mortality. AIM: To evaluate the clinical characteristics, course of illness, end-organ damage and survival outcome in patients with hypertensive crisis. METHODOLOGY: This prospective observational year-long study was conducted after due ethical considerations on 120 adult non-pregnant patients who presented with blood pressure of >180/120 mm Hg in the emergency medical services of a tertiary care hospital...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28757918/low-doses-of-amitriptyline-pregabalin-and-gabapentin-are-preferred-for-management-of-neuropathic-pain-in-india-is-there-a-need-for-revisiting-dosing-recommendations
#9
Sanjay Vasant Kamble, Salman Abdulrehman Motlekar, Lyndon Lincoln D'souza, Vinay Nanda Kudrigikar, Sameer Eknath Rao
BACKGROUND: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28717723/cervical-abnormalities-in-south-african-women-living-with-hiv-with-high-screening-and-referral-rates
#10
Ingrid T Katz, Lisa M Butler, Tamaryn L Crankshaw, Alexi A Wright, Karen Bramhill, Dominick A Leone, Janet Giddy, Sean Mould
PURPOSE: To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28667718/acquired-methemoglobinemia-a-sporadic-holi-disaster
#11
Sanjeevani Satish Masavkar, Anupama Mauskar, Gaurav Patwardhan, Vasudeva Bhat, Mamta V Manglani
OBJECTIVE: To study clinical profile and outcome in patients with methemoglobinemia following exposure to toxic colors during Holi festival. METHODS: This retrospective study included 112 children (5 to 12 years) admitted with methemoglobinemia after playing Holi. Clinical and treatment details were reviewed. RESULTS: The common symptoms were giddiness, vomiting and headache. Treatment included thorough skin wash, intravenous fluid and methylene blue in 111 children...
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28598043/clinical-profile-of-hypertensive-emergencies-in-an-intensive-care-unit
#12
Shubhangi V Dhadke, Vithal N Dhadke, Dhruv S Batra
AIMS AND OBJECTIVE: To study the prevalence of hypertensive emergencies in an ICU set up and to study the clinical presentation of hypertensive emergencies related to cardiovascular, neurological and renovascular system. METHODS: Type of Study: Cross-sectional, descriptive study. DURATION OF STUDY: Two years from 1st December 2011 till 30th November 2013. SAMPLE SIZE: 50 patients of hypertensive emergencies admitted to the intensive care unit of Dr...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28579825/durapain-in-symptomatic-treatment-of-severe-acute-pain-a-post-marketing-prospective-multicenter-observational-study-prime-study
#13
Kshitij Shah, Omvijay B Chaudhari, Palash Gupta, R Hom Chaudhuri, Ranjan Kamilya, Shreedhar S Kulkarni, S Subbaiah, Zubair H Sorathia, Gauri Billa
OBJECTIVE: To assess the effectiveness, overall tolerability, and gastrointestinal (GI) tolerability of Durapain (fixed dose combination of tramadol hydrochloride immediate release [50 mg] and diclofenac sodium sustained release [75 mg]) in symptomatic treatment of severe acute pain in physician's routine clinical practice. MATERIALS AND METHODS: In this prospective, multicenter, observational, post-marketing study, adult patients (aged 18-60 years) with severe acute pain were treated with tramadol hydrochloride/diclofenac sodium as per approved prescribing information...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28504699/expansion-of-the-redox-sensitive-proteome-coincides-with-the-plastid-endosymbiosis
#14
Christian Woehle, Tal Dagan, Giddy Landan, Assaf Vardi, Shilo Rosenwasser
The redox-sensitive proteome (RSP) consists of protein thiols that undergo redox reactions, playing an important role in coordinating cellular processes. Here, we applied a large-scale phylogenomic reconstruction approach in the model diatom Phaeodactylum tricornutum to map the evolutionary origins of the eukaryotic RSP. The majority of P. tricornutum redox-sensitive cysteines (76%) is specific to eukaryotes, yet these are encoded in genes that are mostly of a prokaryotic origin (57%). Furthermore, we find a threefold enrichment in redox-sensitive cysteines in genes that were gained by endosymbiotic gene transfer during the primary plastid acquisition...
May 15, 2017: Nature Plants
https://www.readbyqxmd.com/read/28472693/salivary-alpha-amylase-and-noradrenaline-responses-to-corticotropin-releasing-hormone-administration-in-humans
#15
Liubov Petrakova, Karoline Boy, Lisa Mittmann, Lars Möller, Harald Engler, Manfred Schedlowski
Salivary alpha-amylase (sAA) is a digestive enzyme mainly responsible for the hydrolysis of starch and glycogen in the oral cavity. Since the secretion of sAA is largely under the control of the sympathetic nervous system, sAA activity is also considered to be a non-invasive marker of sympathetic activation. However, the direct association between sAA activity and other sympathetic parameters remains questionable. Therefore, we employed the corticotropin-releasing hormone (CRH) stimulation test to pharmacologically activate the sympathetic nervous system and to analyze plasma noradrenaline response together with sAA activity...
May 1, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28277209/importance-of-an-interprofessional-team-approach-in-achieving-improved-management-of-the-dizzy-patient
#16
Amanda I Rodriguez, Steven Zupancic, Michael M Song, Joehassin Cordero, Tam Q Nguyen, Charles Seifert
BACKGROUND: Because of its multifaceted nature, dizziness is difficult for clinicians to diagnose and manage independently. Current treatment trends suggest that patients are often referred to the otolaryngologist for intervention despite having a nonotologic disorder. Additionally, many individuals with atypical presentations are often misdiagnosed and spend a significant amount of time waiting for consultation by the otolaryngologist. Few studies have alluded that implementation of an interprofessional team approach in the diagnosis and management of the dizzy patient can improve clinical decision-making...
March 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28199635/late-mitochondrial-origin-is-an-artifact
#17
William F Martin, Mayo Roettger, Chuan Ku, Sriram G Garg, Shijulal Nelson-Sathi, Giddy Landan
The origin of mitochondria was a crucial event in eukaryote evolution. A recent report claimed to provide evidence, based on branch length variation in phylogenetic trees, that the mitochondrion came late in eukaryotic evolution. Here, we reinvestigate their claim with a reanalysis of the published data. We show that the analyses underpinning a late mitochondrial origin suffer from multiple fatal flaws founded in inappropriate statistical methods and analyses, in addition to erroneous interpretations.
February 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28111692/clinics-in-diagnostic-imaging-173-scimitar-syndrome-with-horseshoe-lung
#18
Vishal Gaikwad, Ashish Chawla, Tze Chwan Lim, Wilfred Cg Peh
A 56-year-old Chinese man presented with giddiness and vertigo. Subsequent chest radiography showed the classic scimitar sign of an abnormal pulmonary venous return. Further evaluation with non-contrast computed tomography substantiated the finding of a partial anomalous venous drainage pattern and identified an associated rare lung anomaly, horseshoe lung. The imaging findings of scimitar syndrome and its association with horseshoe lung are reviewed.
January 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28060226/barriers-to-care-and-1-year-mortality-among-newly-diagnosed-hiv-infected-people-in-durban-south-africa
#19
Ingrid V Bassett, Sharon M Coleman, Janet Giddy, Laura M Bogart, Christine E Chaisson, Douglas Ross, Moses J E Flash, Tessa Govender, Rochelle P Walensky, Kenneth A Freedberg, Elena Losina
BACKGROUND: Prompt entry into HIV care is often hindered by personal and structural barriers. Our objective was to evaluate the impact of self-perceived barriers to health care on 1-year mortality among newly diagnosed HIV-infected individuals in Durban, South Africa. METHODS: Before HIV testing at 4 outpatient sites, adults (≥18 years) were surveyed regarding perceived barriers to care including (1) service delivery, (2) financial, (3) personal health perception, (4) logistical, and (5) structural...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27843183/low-prevalence-of-anaemia-among-the-wives-of-serving-personnel-in-a-military-station-a-community-based-study
#20
Puja Dudeja, Rohit Tewari, Amarjeet Singh, S D Roy
BACKGROUND: Various studies in India have reported the prevalence of anaemia to be more than 50% among women of the reproductive age group. A community-based study was done to find out the prevalence of anaemia in non-pregnant, non-lactating wives of serving soldiers in a military station. METHODS: It was a cross-sectional study. The sample size was 600. Venous blood was collected for haemoglobin and ferritin levels. Analysis was done by SPSS 20. RESULTS: The mean age at marriage was 19...
October 2016: Medical Journal, Armed Forces India
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