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https://www.readbyqxmd.com/read/29771363/multiple-sequence-alignment-averaging-improves-phylogeny-reconstruction
#1
Haim Ashkenazy, Itamar Sela, Eli Levy Karin, Giddy Landan, Tal Pupko
The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the MSA is correct. Yet, inferred MSAs were shown to be inaccurate and alignment errors reduce tree inference accuracy. It was previously proposed that filtering unreliable alignment regions can increase the accuracy of tree inference. However, it was also demonstrated that the benefit of this filtering is often obscured by the resulting loss of phylogenetic signal...
May 15, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29533336/diagnoses-of-dizziness-and-vertigo-related-disorders-in-ent-practices-in-germany
#2
David Ulrich Seidel, Jonas Jae-Hyun Park, Andreas M Sesterhenn, Karel Kostev
AIM: The aim of this study was to analyze the prevalence of dizziness- and vertigo-related diagnoses in ear, nose, and throat (ENT) practices in Germany and the associated demographic characteristics based on data from a representative nationwide practice database. METHOD: The study sample included patients from 138 ENT practices in Germany who received dizziness- and vertigorelated diagnoses (ICD-10 code) between January 2012 and December 2015. Collected parameters included age, sex, insurance status, prescribed medication (anatomical therapeutic chemical [ATC] class), and referrals to other specialists and hospitals...
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29388565/phylogenetic-rooting-using-minimal-ancestor-deviation
#3
Fernando Domingues Kümmel Tria, Giddy Landan, Tal Dagan
Ancestor-descendent relations play a cardinal role in evolutionary theory. Those relations are determined by rooting phylogenetic trees. Existing rooting methods are hampered by evolutionary rate heterogeneity or the unavailability of auxiliary phylogenetic information. Here we present a rooting approach, the minimal ancestor deviation (MAD) method, which accommodates heterotachy by using all pairwise topological and metric information in unrooted trees. We demonstrate the performance of the method, in comparison to existing rooting methods, by the analysis of phylogenies from eukaryotes and prokaryotes...
June 19, 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29238692/migraine-related-vertigo
#4
Vithal D Udagatti, Rajendran Dinesh Kumar
Migraine related vertigo (MRV) is largely accepted in the vestibular community and probably represents the second most common cause of vertigo after benign positional vertigo by far exceeding Meniere's disease. The data on vestibular migraine management is still relatively poor, despite its enormous importance in daily practice. A 55-year old male presented with history of giddiness, imbalance, sweating and sensation of nausea with severe pulsating headache of one day duration. Ear, Nose and Throat examination was normal...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29218211/a-rare-anatomical-variant-transosseous-supraclavicular-nerve-identified-during-clavicle-fracture-fixation
#5
Jasdeep Giddie, Rachel Fisher, Andrew White
We describe a rare case of an anatomical variant of the supraclavicular nerve in the intra-operative setting of clavicle fixation for a fracture. Intra-operatively it was noted that one of the supraclavicular nerves was passing through a foramen in the clavicle shaft. A 60-year-old gentleman presented with a displaced multifragmentary fracture of the left clavicle after a fall. Plate fixation with a pre-contoured locking plate was performed under general anaesthesia. The clavicle was exposed through an infraclavicular transverse incision...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29206723/brief-report-assessing-the-association-between-changing-nrtis-when-initiating-second-line-art-and-treatment-outcomes
#6
Julia K Rohr, Prudence Ive, Charles Robert Horsburgh, Rebecca Berhanu, Christopher J Hoffmann, Robin Wood, Andrew Boulle, Janet Giddy, Hans Prozesky, Michael Vinikoor, Mwanza Wa Mwanza, Gilles Wandeler, Mary-Ann Davies, Matthew P Fox
BACKGROUND: After first-line antiretroviral therapy failure, the importance of change in nucleoside reverse transcriptase inhibitor (NRTI) in second line is uncertain due to the high potency of protease inhibitors used in second line. SETTING: We used clinical data from 6290 adult patients in South Africa and Zambia from the International Epidemiologic Databases to Evaluate AIDS (IeDEA) Southern Africa cohort. METHODS: We included patients who initiated on standard first-line antiretroviral therapy and had evidence of first-line failure...
April 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29142367/case-of-carcinoma-breast-with-unusually-large-tumor-thrombus-in-superior-vena-cava-detected-on-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan
#7
Arun Sasikumar, Anto Baby, Mathews Jose, Retcy Mary Paul
A 60-year-old female with triple negative breast cancer, postsurgery, neoadjuvant chemotherapy and radiotherapy, on follow-up had facial puffiness and giddiness.18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) done for suspected recurrence evaluation revealed a large tumor thrombus (TT) in superior vena cava (SVC) with radiological evidence of SVC obstruction.18 F-FDG PET/CT also showed evidence of FDG avid brain metastases, lymph nodal metastases, and metastatic soft tissue deposits...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29113957/population-change-of-trillium-govanianum-melanthiaceae-amid-altered-indigenous-harvesting-practices-in-the-indian-himalayas
#8
Harsh K Chauhan, Anil K Bisht, Indra D Bhatt, Arvind Bhatt, David Gallacher, Andrea Santo
ETHNOBOTANICAL RELEVANCE: Trillium govanianum Wall. ex D. Don (Melanthiaceae) is valued as a traditional medicinal herb in the Himalayan region. Applications include treatment of cancer, hypertension, neurasthenia, giddiness, arthritis, dysentery, inflammation, sepsis and reproductive disorders. Its range is highly specific, and limited to cold, shaded and moist habitats at 2400-3500 m a.s.l. Rhizomes are gathered from wild populations for trade, and this has recently emerged as a significant source of income among indigenous people of the Indian Himalayan region...
March 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28989893/an-intriguing-family-with-type-2-diabetes-mellitus-and-complete-heart-block
#9
Gaurav Agarwal, Satish Kumar Singh
Chronic hyperglycaemia of Type 2 Diabetes Mellitus (T2DM) causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias. A 62 year old male presented to our emergency with complaint of sudden onset giddiness from last 2 hours. This was followed by loss of consciousness. Patient was a known case of T2DM since last 1 year. Family history- patient has two brothers who also have T2DM and both of them also developed Complete Heart Block (CHB) spontaneously...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28979922/clinic-based-urinary-lipoarabinomannan-as-a-biomarker-of-clinical-disease-severity-and-mortality-among-antiretroviral-therapy-naive-human-immunodeficiency-virus-infected-adults-in-south-africa
#10
Paul K Drain, Elena Losina, Sharon M Coleman, Janet Giddy, Douglas Ross, Jeffrey N Katz, Kenneth A Freedberg, Ingrid V Bassett
BACKGROUND: Urinary lipoarabinomannan (LAM) has limited sensitivity for diagnosing active human immunodeficiency virus (HIV)-associated tuberculosis (TB) disease, but LAM screening at HIV diagnosis might identify adults with more severe clinical disease or greater risk of mortality. METHODS: We enrolled antiretroviral therapy-naive HIV-infected adults from 4 clinics in Durban. Nurses performed urine LAM testing using a rapid assay (Determine TB LAM) graded from low (1+) to high (≥3+) intensity...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28972699/ledipasvir-and-sofosbuvir-for-untreated-hcv-genotype-1-infection-in-end-stage-renal-disease-patients-a-prospective-observational-study
#11
Mandarapu Surendra, Sree Bhushan Raju, Nimmagadda Sridhar, Bangillapati Vijay Kiran, Goli Rajesh, Golla Anvesh, Nallagasu Raju
INTRODUCTION: Hepatitis C virus (HCV) infection in end stage renal disease (ESRD) is associated with increased mortality. Recently, numerous directly acting antiviral agents have been approved for the management of HCV. Ledipasvir along with Sofosbuvir has been approved for management of genotype 1 infection in patients with eGFR ≥30 mL/min. However, there is paucity of data regarding its role in the management of patients on dialysis. MATERIAL AND METHODS: This is a single center prospective open label observational study to assess the safety and efficacy of Ledipasvir and Sofosbuvir in hemodialysis (HD) patients who were diagnosed with HCV genotype 1 infection...
October 3, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28874083/azathioprine-induced-pancytopenia-and-septic-complications-a-probable-cause-of-death
#12
Bijoy K Panda, Siddhi Umarje, Arundhati Diwan
Azathioprine, an immunosuppressant which is widely used in the management of the autoimmune neuromuscular disorder. Myasthenia gravis is known to cause myelotoxicity. A 55-year-old male recently diagnosed with myasthenia gravis and chronic kidney disease was put on azathioprine (100 mg/d) along with pyridostigmine and prednisolone. When the treatment was initiated, the hematological reports revealed normal levels of blood count. However, approximately within 3 weeks of continuing the prescribed drugs, the patient was readmitted for complaints of loose watery stools, weakness, and giddiness...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28794532/local-anaesthetic-systemic-toxicity-following-oral-ingestion-in-a-child-revisiting-dibucaine
#13
Raylene Dias, Nandini Dave, Milind S Tullu, Chandrahas T Deshmukh
Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations. Systemic toxicity following oral ingestion of local anaesthetics is rare. We report a case of accidental ingestion of dibucaine (ear drops) in a 7-year-old child who developed diplopia, giddiness, ventricular premature contractions and a right bundle branch block. We also present a brief discussion on the pharmacologic and toxicity profile of dibucaine, the Naranjo algorithm for assessing causality in case of adverse drug reactions and a review of current guidelines on the management of local anaesthetic systemic toxicity...
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28782308/a-prospective-observational-study-to-determine-the-prevalence-and-clinical-profile-of-patients-of-hypertensive-crisis-in-a-tertiary-care-hospital
#14
Santosh B Salagre, Shobha M Itolikar, Kapil Gedam
BACKGROUND: Hypertension can present in crisis form as 'hypertensive urgency'(HU) or as 'hypertensive emergency' (HE). Both the conditions are associated with significant morbidity and mortality. AIM: To evaluate the clinical characteristics, course of illness, end-organ damage and survival outcome in patients with hypertensive crisis. METHODOLOGY: This prospective observational year-long study was conducted after due ethical considerations on 120 adult non-pregnant patients who presented with blood pressure of >180/120 mm Hg in the emergency medical services of a tertiary care hospital...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28757918/low-doses-of-amitriptyline-pregabalin-and-gabapentin-are-preferred-for-management-of-neuropathic-pain-in-india-is-there-a-need-for-revisiting-dosing-recommendations
#15
Sanjay Vasant Kamble, Salman Abdulrehman Motlekar, Lyndon Lincoln D'souza, Vinay Nanda Kudrigikar, Sameer Eknath Rao
BACKGROUND: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28717723/cervical-abnormalities-in-south-african-women-living-with-hiv-with-high-screening-and-referral-rates
#16
Ingrid T Katz, Lisa M Butler, Tamaryn L Crankshaw, Alexi A Wright, Karen Bramhill, Dominick A Leone, Janet Giddy, Sean Mould
PURPOSE: To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28667718/acquired-methemoglobinemia-a-sporadic-holi-disaster
#17
Sanjeevani Satish Masavkar, Anupama Mauskar, Gaurav Patwardhan, Vasudeva Bhat, Mamta V Manglani
OBJECTIVE: To study clinical profile and outcome in patients with methemoglobinemia following exposure to toxic colors during Holi festival. METHODS: This retrospective study included 112 children (5 to 12 years) admitted with methemoglobinemia after playing Holi. Clinical and treatment details were reviewed. RESULTS: The common symptoms were giddiness, vomiting and headache. Treatment included thorough skin wash, intravenous fluid and methylene blue in 111 children...
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28598043/clinical-profile-of-hypertensive-emergencies-in-an-intensive-care-unit
#18
Shubhangi V Dhadke, Vithal N Dhadke, Dhruv S Batra
AIMS AND OBJECTIVE: To study the prevalence of hypertensive emergencies in an ICU set up and to study the clinical presentation of hypertensive emergencies related to cardiovascular, neurological and renovascular system. METHODS: Type of Study: Cross-sectional, descriptive study. DURATION OF STUDY: Two years from 1st December 2011 till 30th November 2013. SAMPLE SIZE: 50 patients of hypertensive emergencies admitted to the intensive care unit of Dr...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28579825/durapain-in-symptomatic-treatment-of-severe-acute-pain-a-post-marketing-prospective-multicenter-observational-study-prime-study
#19
Kshitij Shah, Omvijay B Chaudhari, Palash Gupta, R Hom Chaudhuri, Ranjan Kamilya, Shreedhar S Kulkarni, S Subbaiah, Zubair H Sorathia, Gauri Billa
OBJECTIVE: To assess the effectiveness, overall tolerability, and gastrointestinal (GI) tolerability of Durapain (fixed dose combination of tramadol hydrochloride immediate release [50 mg] and diclofenac sodium sustained release [75 mg]) in symptomatic treatment of severe acute pain in physician's routine clinical practice. MATERIALS AND METHODS: In this prospective, multicenter, observational, post-marketing study, adult patients (aged 18-60 years) with severe acute pain were treated with tramadol hydrochloride/diclofenac sodium as per approved prescribing information...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28504699/expansion-of-the-redox-sensitive-proteome-coincides-with-the-plastid-endosymbiosis
#20
Christian Woehle, Tal Dagan, Giddy Landan, Assaf Vardi, Shilo Rosenwasser
The redox-sensitive proteome (RSP) consists of protein thiols that undergo redox reactions, playing an important role in coordinating cellular processes. Here, we applied a large-scale phylogenomic reconstruction approach in the model diatom Phaeodactylum tricornutum to map the evolutionary origins of the eukaryotic RSP. The majority of P. tricornutum redox-sensitive cysteines (76%) is specific to eukaryotes, yet these are encoded in genes that are mostly of a prokaryotic origin (57%). Furthermore, we find a threefold enrichment in redox-sensitive cysteines in genes that were gained by endosymbiotic gene transfer during the primary plastid acquisition...
May 15, 2017: Nature Plants
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