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https://www.readbyqxmd.com/read/28794532/local-anaesthetic-systemic-toxicity-following-oral-ingestion-in-a-child-revisiting-dibucaine
#1
Raylene Dias, Nandini Dave, Milind S Tullu, Chandrahas T Deshmukh
Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations. Systemic toxicity following oral ingestion of local anaesthetics is rare. We report a case of accidental ingestion of dibucaine (ear drops) in a 7-year-old child who developed diplopia, giddiness, ventricular premature contractions and a right bundle branch block. We also present a brief discussion on the pharmacologic and toxicity profile of dibucaine, the Naranjo algorithm for assessing causality in case of adverse drug reactions and a review of current guidelines on the management of local anaesthetic systemic toxicity...
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28782308/a-prospective-observational-study-to-determine-the-prevalence-and-clinical-profile-of-patients-of-hypertensive-crisis-in-a-tertiary-care-hospital
#2
Santosh B Salagre, Shobha M Itolikar, Kapil Gedam
BACKGROUND: Hypertension can present in crisis form as 'hypertensive urgency'(HU) or as 'hypertensive emergency' (HE). Both the conditions are associated with significant morbidity and mortality. AIM: To evaluate the clinical characteristics, course of illness, end-organ damage and survival outcome in patients with hypertensive crisis. METHODOLOGY: This prospective observational year-long study was conducted after due ethical considerations on 120 adult non-pregnant patients who presented with blood pressure of >180/120 mm Hg in the emergency medical services of a tertiary care hospital...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28757918/low-doses-of-amitriptyline-pregabalin-and-gabapentin-are-preferred-for-management-of-neuropathic-pain-in-india-is-there-a-need-for-revisiting-dosing-recommendations
#3
Sanjay Vasant Kamble, Salman Abdulrehman Motlekar, Lyndon Lincoln D'souza, Vinay Nanda Kudrigikar, Sameer Eknath Rao
BACKGROUND: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent Indian market data suggested that the utilization (sale) of drugs such as amitriptyline, pregabalin, and gabapentin was more for low-dose unit packs than that of the high-dose unit packs, raising the belief that these drugs are prescribed at a lower dose than is actually recommended in the guidelines...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28717723/cervical-abnormalities-in-south-african-women-living-with-hiv-with-high-screening-and-referral-rates
#4
Ingrid T Katz, Lisa M Butler, Tamaryn L Crankshaw, Alexi A Wright, Karen Bramhill, Dominick A Leone, Janet Giddy, Sean Mould
PURPOSE: To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28667718/acquired-methemoglobinemia-a-sporadic-holi-disaster
#5
Sanjeevani Satish Masavkar, Anupama Mauskar, Gaurav Patwardhan, Vasudeva Bhat, Mamta V Manglani
OBJECTIVE: To study clinical profile and outcome in patients with methemoglobinemia following exposure to toxic colors during Holi festival. METHODS: This retrospective study included 112 children (5 to 12 years) admitted with methemoglobinemia after playing Holi. Clinical and treatment details were reviewed. RESULTS: The common symptoms were giddiness, vomiting and headache. Treatment included thorough skin wash, intravenous fluid and methylene blue in 111 children...
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28598043/clinical-profile-of-hypertensive-emergencies-in-an-intensive-care-unit
#6
Shubhangi V Dhadke, Vithal N Dhadke, Dhruv S Batra
AIMS AND OBJECTIVE: To study the prevalence of hypertensive emergencies in an ICU set up and to study the clinical presentation of hypertensive emergencies related to cardiovascular, neurological and renovascular system. METHODS: Type of Study: Cross-sectional, descriptive study. DURATION OF STUDY: Two years from 1st December 2011 till 30th November 2013. SAMPLE SIZE: 50 patients of hypertensive emergencies admitted to the intensive care unit of Dr...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28579825/durapain-in-symptomatic-treatment-of-severe-acute-pain-a-post-marketing-prospective-multicenter-observational-study-prime-study
#7
Kshitij Shah, Omvijay B Chaudhari, Palash Gupta, R Hom Chaudhuri, Ranjan Kamilya, Shreedhar S Kulkarni, S Subbaiah, Zubair H Sorathia, Gauri Billa
OBJECTIVE: To assess the effectiveness, overall tolerability, and gastrointestinal (GI) tolerability of Durapain (fixed dose combination of tramadol hydrochloride immediate release [50 mg] and diclofenac sodium sustained release [75 mg]) in symptomatic treatment of severe acute pain in physician's routine clinical practice. MATERIALS AND METHODS: In this prospective, multicenter, observational, post-marketing study, adult patients (aged 18-60 years) with severe acute pain were treated with tramadol hydrochloride/diclofenac sodium as per approved prescribing information...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28504699/expansion-of-the-redox-sensitive-proteome-coincides-with-the-plastid-endosymbiosis
#8
Christian Woehle, Tal Dagan, Giddy Landan, Assaf Vardi, Shilo Rosenwasser
The redox-sensitive proteome (RSP) consists of protein thiols that undergo redox reactions, playing an important role in coordinating cellular processes. Here, we applied a large-scale phylogenomic reconstruction approach in the model diatom Phaeodactylum tricornutum to map the evolutionary origins of the eukaryotic RSP. The majority of P. tricornutum redox-sensitive cysteines (76%) is specific to eukaryotes, yet these are encoded in genes that are mostly of a prokaryotic origin (57%). Furthermore, we find a threefold enrichment in redox-sensitive cysteines in genes that were gained by endosymbiotic gene transfer during the primary plastid acquisition...
May 15, 2017: Nature Plants
https://www.readbyqxmd.com/read/28472693/salivary-alpha-amylase-and-noradrenaline-responses-to-corticotropin-releasing-hormone-administration-in-humans
#9
Liubov Petrakova, Karoline Boy, Lisa Mittmann, Lars Möller, Harald Engler, Manfred Schedlowski
Salivary alpha-amylase (sAA) is a digestive enzyme mainly responsible for the hydrolysis of starch and glycogen in the oral cavity. Since the secretion of sAA is largely under the control of the sympathetic nervous system, sAA activity is also considered to be a non-invasive marker of sympathetic activation. However, the direct association between sAA activity and other sympathetic parameters remains questionable. Therefore, we employed the corticotropin-releasing hormone (CRH) stimulation test to pharmacologically activate the sympathetic nervous system and to analyze plasma noradrenaline response together with sAA activity...
May 1, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28277209/importance-of-an-interprofessional-team-approach-in-achieving-improved-management-of-the-dizzy-patient
#10
Amanda I Rodriguez, Steven Zupancic, Michael M Song, Joehassin Cordero, Tam Q Nguyen, Charles Seifert
BACKGROUND: Because of its multifaceted nature, dizziness is difficult for clinicians to diagnose and manage independently. Current treatment trends suggest that patients are often referred to the otolaryngologist for intervention despite having a nonotologic disorder. Additionally, many individuals with atypical presentations are often misdiagnosed and spend a significant amount of time waiting for consultation by the otolaryngologist. Few studies have alluded that implementation of an interprofessional team approach in the diagnosis and management of the dizzy patient can improve clinical decision-making...
March 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28199635/late-mitochondrial-origin-is-an-artefact
#11
William F Martin, Mayo Roettger, Chuan Ku, Sriram G Garg, Shijulal Nelson-Sathi, Giddy Landan
No abstract text is available yet for this article.
February 11, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28111692/clinics-in-diagnostic-imaging-173-scimitar-syndrome-with-horseshoe-lung
#12
Vishal Gaikwad, Ashish Chawla, Tze Chwan Lim, Wilfred Cg Peh
A 56-year-old Chinese man presented with giddiness and vertigo. Subsequent chest radiography showed the classic scimitar sign of an abnormal pulmonary venous return. Further evaluation with non-contrast computed tomography substantiated the finding of a partial anomalous venous drainage pattern and identified an associated rare lung anomaly, horseshoe lung. The imaging findings of scimitar syndrome and its association with horseshoe lung are reviewed.
January 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28060226/barriers-to-care-and-1-year-mortality-among-newly-diagnosed-hiv-infected-people-in-durban-south-africa
#13
Ingrid V Bassett, Sharon M Coleman, Janet Giddy, Laura M Bogart, Christine E Chaisson, Douglas Ross, Moses J E Flash, Tessa Govender, Rochelle P Walensky, Kenneth A Freedberg, Elena Losina
BACKGROUND: Prompt entry into HIV care is often hindered by personal and structural barriers. Our objective was to evaluate the impact of self-perceived barriers to health care on 1-year mortality among newly diagnosed HIV-infected individuals in Durban, South Africa. METHODS: Before HIV testing at 4 outpatient sites, adults (≥18 years) were surveyed regarding perceived barriers to care including (1) service delivery, (2) financial, (3) personal health perception, (4) logistical, and (5) structural...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27843183/low-prevalence-of-anaemia-among-the-wives-of-serving-personnel-in-a-military-station-a-community-based-study
#14
Puja Dudeja, Rohit Tewari, Amarjeet Singh, S D Roy
BACKGROUND: Various studies in India have reported the prevalence of anaemia to be more than 50% among women of the reproductive age group. A community-based study was done to find out the prevalence of anaemia in non-pregnant, non-lactating wives of serving soldiers in a military station. METHODS: It was a cross-sectional study. The sample size was 600. Venous blood was collected for haemoglobin and ferritin levels. Analysis was done by SPSS 20. RESULTS: The mean age at marriage was 19...
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27842535/rapid-urine-lipoarabinomannan-assay-as-a-clinic-based-screening-test-for-active-tuberculosis-at-hiv-diagnosis
#15
Paul K Drain, Elena Losina, Sharon M Coleman, Janet Giddy, Douglas Ross, Jeffrey N Katz, Ingrid V Bassett
BACKGROUND: World Health Organization (WHO) recommends tuberculosis (TB) screening at HIV diagnosis. We evaluated the inclusion of rapid urine lipoarabinomannan (LAM) testing in TB screening algorithms. METHODS: We enrolled ART-naïve adults who screened HIV-infected in KwaZulu-Natal, assessed TB-related symptoms (cough, fever, night sweats, weight loss), and obtained sputum specimens for mycobacterial culture. Trained nurses performed clinic-based urine LAM testing using a rapid assay...
November 14, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27805349/infantile-preductal-coarctation-of-aorta-presenting-as-cerebellar-infarct-a-rare-presentation
#16
A Sivaraman, Maniram Kumhar, Utsav Kimar Sahu, Manoj Kumar Mali
Coarctation of aorta is a common congenital heart defect. The diagnosis may be missed unless a highindex of suspicion is maintained, and is often delayed until the patient develops congestive heart failure (CHF), (common in infants) or hypertension (common in older children). It seldom goes undiagnosed till adulthood and frequently leads to complications as a result of long-standing high blood pressure. Intracranial haemorrhage, premature coronary artery disease, aortic aneurysms and rupture have all been reported...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27765035/biovel-a-virtual-laboratory-for-data-analysis-and-modelling-in-biodiversity-science-and-ecology
#17
Alex R Hardisty, Finn Bacall, Niall Beard, Maria-Paula Balcázar-Vargas, Bachir Balech, Zoltán Barcza, Sarah J Bourlat, Renato De Giovanni, Yde de Jong, Francesca De Leo, Laura Dobor, Giacinto Donvito, Donal Fellows, Antonio Fernandez Guerra, Nuno Ferreira, Yuliya Fetyukova, Bruno Fosso, Jonathan Giddy, Carole Goble, Anton Güntsch, Robert Haines, Vera Hernández Ernst, Hannes Hettling, Dóra Hidy, Ferenc Horváth, Dóra Ittzés, Péter Ittzés, Andrew Jones, Renzo Kottmann, Robert Kulawik, Sonja Leidenberger, Päivi Lyytikäinen-Saarenmaa, Cherian Mathew, Norman Morrison, Aleksandra Nenadic, Abraham Nieva de la Hidalga, Matthias Obst, Gerard Oostermeijer, Elisabeth Paymal, Graziano Pesole, Salvatore Pinto, Axel Poigné, Francisco Quevedo Fernandez, Monica Santamaria, Hannu Saarenmaa, Gergely Sipos, Karl-Heinz Sylla, Marko Tähtinen, Saverio Vicario, Rutger Aldo Vos, Alan R Williams, Pelin Yilmaz
BACKGROUND: Making forecasts about biodiversity and giving support to policy relies increasingly on large collections of data held electronically, and on substantial computational capability and capacity to analyse, model, simulate and predict using such data. However, the physically distributed nature of data resources and of expertise in advanced analytical tools creates many challenges for the modern scientist. Across the wider biological sciences, presenting such capabilities on the Internet (as "Web services") and using scientific workflow systems to compose them for particular tasks is a practical way to carry out robust "in silico" science...
October 20, 2016: BMC Ecology
https://www.readbyqxmd.com/read/27695568/papillary-tumor-of-pineal-region-a-rare-entity
#18
Meena Patil, Manjiri Karandikar
Pineal tumors comprise 0.4 - 1.0% of intracranial space-occupying lesions in adults. Papillary tumor of pineal region (PTPR) is a very rare entity. It has been newly described in WHO 2007 classification of brain tumors. Only a few case reports are available in the literature. We report a case of a 60 year-old female presenting with headache, giddiness and reduced vision. Imaging studies showed a pineal mass with areas of hemorrhage. All ventricles were normal. There was a past history of a pineal gland tumor excised 2 years ago...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27648812/phylogenomic-networks-reveal-limited-phylogenetic-range-of-lateral-gene-transfer-by-transduction
#19
Ovidiu Popa, Giddy Landan, Tal Dagan
Bacteriophages are recognized DNA vectors and transduction is considered as a common mechanism of lateral gene transfer (LGT) during microbial evolution. Anecdotal events of phage-mediated gene transfer were studied extensively, however, a coherent evolutionary viewpoint of LGT by transduction, its extent and characteristics, is still lacking. Here we report a large-scale evolutionary reconstruction of transduction events in 3982 genomes. We inferred 17 158 recent transduction events linking donors, phages and recipients into a phylogenomic transduction network view...
February 2017: ISME Journal
https://www.readbyqxmd.com/read/27632145/sizanani-a-randomized-trial-of-health-system-navigators-to-improve-linkage-to-hiv-and-tb-care-in-south-africa
#20
RANDOMIZED CONTROLLED TRIAL
Ingrid V Bassett, Sharon M Coleman, Janet Giddy, Laura M Bogart, Christine E Chaisson, Douglas Ross, Margo M Jacobsen, Marion Robine, Tessa Govender, Kenneth A Freedberg, Jeffrey N Katz, Rochelle P Walensky, Elena Losina
BACKGROUND: A fraction of HIV-diagnosed individuals promptly initiate antiretroviral therapy (ART). We evaluated the efficacy of health system navigators for improving linkage to HIV and tuberculosis (TB) care among newly diagnosed HIV-infected outpatients in Durban, South Africa. METHODS: We conducted a randomized controlled trial (Sizanani Trial, NCT01188941) among adults (≥18 years) at 4 sites. Participants underwent TB screening and randomization into a health system navigator intervention or usual care...
October 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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