keyword
MENU ▼
Read by QxMD icon Read
search

Sebaceous neoplasm

keyword
https://www.readbyqxmd.com/read/27822395/generational-expression-of-muir-torre-syndrome-in-a-canadian-family
#1
Kaitlin Alexandra Vanderbeck, R Gary Sibbald, Nirosha Murugan
Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of a 57-year-old female patient with MTS. She has a confirmed HMSH2 mutation. Recently she presented with two nodular lesions. Histologic examination confirmed these lesions to be sebaceous neoplasms. The patient has a history of endometrial and colorectal adenocarcinoma as well as several nonspecific sebaceous lesions throughout her life...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/27771121/-muir-torre-syndrome-associated-with-waldenstrom-s-macroglobulinemia
#2
C Velter, F Bourlond, C Wettle, B Lioure, D Lipsker, C Maugard, B Cribier
BACKGROUND: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system. PATIENTS AND METHODS: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas)...
October 19, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27763901/extraocular-sebaceous-carcinoma-a-clinicopathologic-reassessment
#3
Nicole M Candelario, Julio E Sánchez, Jorge L Sánchez, Rafael F Martín-García, Nicole M Rochet
Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. More cases occurred in men (60%), with a mean age at diagnosis of 65.8 years (range 39-99 years). Neoplasms were histopathologically classified as well-differentiated (22%), moderately differentiated (67%), and poorly differentiated (11%)...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27745640/universal-immunohistochemical-screening-of-sebaceous-neoplasms-for-muir-torre-syndrome-putting-the-cart-before-the-horse
#4
Randie H Kim, Arielle R Nagler, Shane A Meehan
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27632187/multicentric-squamous-odontogenic-tumor-a-case-report-and-review-of-the-literature
#5
Sophia Elmuradi, Yasmin Mair, Lakshmanan Suresh, James DeSantis, Mirdza Neiders, Alfredo Aguirre
Squamous odontogenic tumor (SOT) is a rare benign epithelial odontogenic neoplasm of the jaws. Both intraosseous and peripheral SOTs have been described in the English language literature. While most intraosseous SOTs occur as solitary lesions, a multicentric variant has also been previously described. Although the radiographic and microscopic features are identical for both solitary and multicentric clinical presentations, there are three significant differences between them. More specifically, multicentric SOT presents at an earlier age (third decade of life), has a slightly higher male to female ratio than the solitary type and has a marked predilection for African-Americans...
September 8, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27507045/sebaceous-mantleoma-mantle-adenoma-reappraisal-of-the-legend-of-the-problematic-benign-neoplasm-with-sebaceous-mantle-differentiation
#6
Keisuke Goto, Noriyuki Misago, Noriyoshi Sumiya, Yukio Ishikawa
Few cases of a true benign neoplasm with sebaceous mantle differentiation have been reported, and little is known about this tumor. Herein, we present a rare case of the neoplasm called sebaceous mantleoma, along with a comparison of the histology and immunoprofile with those of normal sebaceous mantles. A pedunculated polyp occurred on the scalp of a 51-year-old woman. Histopathologically, the tumor showed lobulated epithelial-mesenchymal units that were separated from the normal dermis by clefts. The lesion was composed of cords and columns of basaloid cells containing a few mature sebocytes, with a focal connection to infundibulocystic structures as well as dense fibrotic or fibromyxoid stroma...
August 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27373129/coexistent-trichilemmoma-and-trichoblastoma-without-associated-nevus-sebaceus
#7
A M Stowman, M M Griffin, W A Kanner, G Tchernev, A A Chokoeva, U Wollina, T Lotti, M Fioranelli, M G Roccia, G K Maximov, J W Patterson
Trichilemmoma and trichoblastoma are benign adnexal neoplasms derived from the hair follicle unit. While trichilemmomas are closely associated with the epidermis, trichoblastomas are found within the dermis and subcutaneous tissue. Both tumors have been reported to arise within nevus sebaceus of Jadassohn (NSJ). We present a 42-year-old white male with a 5 mm crusted, erythematous papule on the right occipital scalp that had been present for years. A shave biopsy was performed and read as trichilemmoma involving the biopsy base...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27357288/discordant-mismatch-repair-protein-immunoreactivity-in-lynch-syndrome-associated-neoplasms-%C3%A2-a-recommendation-for-screening-synchronous-metachronous-neoplasms
#8
Rachel M Roth, Sigurdis Haraldsdottir, Heather Hampel, Christina A Arnold, Wendy L Frankel
OBJECTIVES: Lynch syndrome (LS) predisposes individuals to developing synchronous and metachronous LS-associated neoplasms (LSANs). Mismatch repair protein (MMRP) immunohistochemistry (IHC) is widely used to identify LS, but its utility in patients with synchronous/metachronous lesions has not been studied. We studied MMRP IHC in patients with LS with more than one LSAN to provide screening recommendations in patients with synchronous/metachronous neoplasms. METHODS: All patients with LS diagnosed at The Ohio State University Wexner Medical Center from 2009 through 2014 with more than one LSAN and available tumor tissue for immunostaining were identified...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27323599/an-unusual-presentation-of-huge-meningioma-extruding-out-of-skull
#9
Mirza Faisal Ahmed Rafiq, Khaleeq-uz-Zaman, Muhammad Ibrahima
Scalp masses are commonly seen in clinical practice. They range from simple sebaceous cyst to malignant neoplasms. Clinical presentation is straight forward in most of the cases. Simple subcutaneous swelling till erosion of scalp and skull all can occur. However very few intracranial masses present with exophytic scalp swelling. This is because they have to erode dura, thick skull bone and all the layers of scalp to appear out on scalp. It is very unusual that an intracranial mass present like a scalp swelling...
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/27311873/circumscribed-sebaceous-neoplasms-a-morphological-immunohistochemical-and-molecular-analysis
#10
Nathan Tobias Harvey, Tania Tabone, Wendy Erber, Benjamin Andrew Wood
Sebaceous neoplasms encompass a range of lesions, including benign entities such as sebaceous adenoma and sebaceoma, as well as sebaceous carcinoma. The distinction of sebaceous carcinoma from benign lesions relies on histological identification of architectural or cytological features of malignancy. In this study we have assessed the diagnostic discriminatory ability of mitotic rate and immunohistochemical markers (p53, bcl-2 and p16) in a selected group of well circumscribed sebaceous neoplasms, incorporating examples of sebaceous adenoma, sebaceoma and sebaceous carcinoma...
August 2016: Pathology
https://www.readbyqxmd.com/read/27218789/sebaceous-carcinoma-of-the-eyelid
#11
Carlos Prieto-Granada, Paul Rodriguez-Waitkus
BACKGROUND: Periocular sebaceous carcinoma (PSC) is a rare but aggressive neoplasm that tends to clinically and histopathologically mimic other conditions. PSC can be challenging to diagnose using histomorphology alone given its overlap with 2 more common tumors that occur in this area (basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]). Use of immunohistochemistry can help resolve this differential diagnosis. METHODS: A review of the literature was performed, focusing on the epidemiology, morphology, and immunohistochemical features of PSC...
April 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27153463/nuclear-factor-xiiia-staining-clone-ac-1a1-mouse-monoclonal-is-a-highly-sensitive-marker-of-sebaceous-differentiation-in-normal-and-neoplastic-sebocytes
#12
Lindsey N Clark, Hillary R Elwood, Elizabeth E Uhlenhake, Bruce R Smoller, Sara C Shalin, Jerad M Gardner
BACKGROUND: Sebaceous proliferations are common and may be confused with other cutaneous neoplasms. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. We incidentally observed strong factor XIIIa (Ventana clone AC-1A1 on Ventana Benchmark Ultra stainer) nuclear staining in normal sebaceous glands and hypothesized that this might be a useful marker in sebaceous proliferations. METHODS: Immunohistochemistry for factor XIIIa (AC-1A1) was performed on seven sebaceous hyperplasias, eight sebaceous adenomas, five sebaceomas, seven sebaceous carcinomas...
August 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27153339/nuclear-factor-xiiia-staining-clone-ac-1a1-mouse-monoclonal-is-a-sensitive-and-specific-marker-to-discriminate-sebaceous-proliferations-from-other-cutaneous-clear-cell-neoplasms
#13
Elizabeth E Uhlenhake, Lindsey N Clark, Bruce R Smoller, Sara C Shalin, Jerad M Gardner
Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Nuclear staining with factor XIIIa (clone AC-1A1) was recently found to be a highly sensitive marker of sebaceous differentiation. We evaluated nuclear factor XIIIa (AC-1A1) staining in sebaceous neoplasms vs. other cutaneous clear cell tumors...
August 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27146927/pathology-of-eyelid-tumors
#14
Jacob Pe'er
The eyelids are composed of four layers: skin and subcutaneous tissue including its adnexa, striated muscle, tarsus with the meibomian glands, and the palpebral conjunctiva. Benign and malignant tumors can arise from each of the eyelid layers. Most eyelid tumors are of cutaneous origin, mostly epidermal, which can be divided into epithelial and melanocytic tumors. Benign epithelial lesions, cystic lesions, and benign melanocytic lesions are very common. The most common malignant eyelid tumors are basal cell carcinoma in Caucasians and sebaceous gland carcinoma in Asians...
March 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27127368/trichoscopy-the-best-auxiliary-tool-in-the-evaluation-of-nevus-sebaceous
#15
Balachandra S Ankad, Savitha L Beergouder, Vijay Domble
INTRODUCTION: Nevus sebaceous (NS) presents as alopecia and yellowish discoloration during infantile stage. In adult stage, lesions become verrucous. Importantly, various appendageal tumors such as trichoblastoma, syringocystadenoma papilliferum and basal cell carcinoma develop during this stage. Hence it is very important to follow the course of NS for early detection of neoplasms. Trichoscopy, being in vivo diagnostic technique, can be utilized in this condition. as it demonstrates specific trichoscopic patterns...
January 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/27093461/surgery-for-benign-salivary-neoplasms
#16
M Boyd Gillespie, Heinrich Iro
Salivary neoplasms are relatively infrequent entities that account for only 4% of tumors of the head and neck. Although slow-growing lesions of the preauricular area and submandibular space are often confused with sebaceous cysts, lymph nodes, or lipomas by the non-otolaryngologist, otolaryngologists-head and neck surgeons recognize that all preauricular and submandibular masses should be considered a salivary neoplasm until proven otherwise. Surgery remains the treatment of choice for benign salivary gland neoplasms; however, techniques continue to evolve in order to preserve salivary function and reduce surgical morbidity...
2016: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27016151/role-of-microsatellite-instability-immunohistochemistry-and-mismatch-repair-germline-aberrations-in-immunosuppressed-transplant-patients-a-phenocopy-dilemma-in-muir-torre-syndrome
#17
Giovanni Ponti, Marco Manfredini, Giovanni Pellacani, Aldo Tomasi
Sebaceous tumours and keratoacanthomas are uncommon neoplasms that constitute important clinical criteria for Muir-Torre syndrome (MTS) diagnosis. In MTS patients, the increased risk of developing synchronous or metachronous visceral malignancies is characterised by autosomal dominant inheritance. However, there are further conditions, other than MTS, that increase the risk of sebaceous neoplasms, e.g. iatrogenic immunosuppression. In this latter scenario, the sebaceous tumours can present microsatellite instability (MSI) and loss of mismatch repair (MMR) proteins, characteristic of hereditary syndromes, even in the absence of MMR germline mutations...
March 25, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/26990478/a-unexpected-growth-arising-within-nevus-sebaceous-of-jadassohn
#18
S A Chan, R Hejmadi, K Webster, M R Kaur
The predisposition to epithelial neoplasms in nevus sebaceous is well established; most tumors occur in adults and are benign. Hidradenoma is a relatively rare benign tumor of sweat gland origin that can rarely arise within a nevus sebaceous. We present an interesting case of a hidradenoma and sebaceoma arising within a nevus sebaceous and present a literature review of the 2 conditions. Even though hidradenoma is a benign tumor, we would advocate complete excision given the potential for malignant transformation...
January 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/26962393/muir-torre-syndrome-a-case-associated-with-an-infrequent-gene-mutation
#19
Alexandra Grob, Christina Feser, Steven Grekin
Muir-Torre syndrome is a rare, autosomal dominant genodermatosis characterized by the presence of at least one sebaceous gland neoplasm, associated with an underlying visceral malignancy. Muir-Torre syndrome is believed to be a subtype of Lynch Syndrome. Affected individuals are found to have germline mutations predominantly in DNA mismatch repair gene MSH2, and much less frequently, MLH1. The authors report the case of a 55-year-old woman presenting with multiple cutaneous neoplasms including sebaceoma, basal cell carcinoma, and squamous cell carcinoma; personal history of colorectal and endometrial cancer; and family history of colorectal cancer; found to have a deletion at mismatch repair gene MLH1...
January 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/26959146/updates-on-the-molecular-pathology-of-selected-ocular-and-ocular-adnexal-tumors-potential-targets-for-future-therapy
#20
Anna M Stagner, Frederick A Jakobiec
Ophthalmic pathologic studies of retinoblastoma first definitively elucidated a genetic etiology for cancer three decades ago. Advances in DNA sequencing, protein expression profiling, and the exploration of epigenetics have since led to categorization of tumors and clinical prognostication based on genetic aberrancy. There are now many neoplasms that are defined by a characteristic genetic signature. In the past several years alone, much has been discovered in regard to the original tumor-suppressor gene initially defined in retinoblastoma as well as in other intraocular tumors such as medulloepithelioma...
2016: Seminars in Ophthalmology
keyword
keyword
44615
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"