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Sebaceous neoplasm

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https://www.readbyqxmd.com/read/28681210/sebaceous-carcinoma-a-review-of-the-scientific-literature
#1
REVIEW
Thomas Knackstedt, Faramarz H Samie
Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. Commonly reported in the periocular area and the head and neck region, sebaceous carcinoma can arise from any sebaceous gland in the skin. The clinical presentation may be nonspecific, and a biopsy is important to establish a diagnosis and to differentiate from mimickers including benign sebaceous neoplasms, other adnexal tumors, and basal cell carcinoma. A diagnosis of Muir Torre syndrome should be considered in patients presenting with a sebaceous neoplasm...
August 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28677299/tdt-expression-in-normal-and-neoplastic-sebaceous-cells
#2
Sofia-Eleni Tzorakoleftheraki, Alexandros Iliadis, Ioannis Kostopoulos, Triantafyllia Koletsa
AIMS: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in immature, normal and neoplastic, lymphoid or hematopoietic cells and in neuroendocrine carcinomas, like Merkel cell carcinoma and small cell carcinoma. It has not yet been described in cells of epithelial origin. After observing TdT immunoreactivity in normal sebaceous glands we analyzed its spectrum of expression in cases of sebaceous cell hyperplasia and sebaceous cell neoplasms. METHODS & RESULTS: Twelve cases of sebaceous gland hyperplasia (SGH), and three cases of other benign lesions, namely, sebaceoma, sebaceous adenoma and sebaceous nevus, along with four archived cases of sebaceous cell carcinomas (SC) were collected and stained with TdT antibody...
July 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28665073/sebaceous-carcinoma-clinicopathologic-analysis-of-29-cases-in-a-tertiary-hospital-in-korea
#3
Su Kyung Park, Jin Park, Han Uk Kim, Seok Kweon Yun
Sebaceous carcinoma (SC) is a neoplasm derived from the adnexal epithelium of the sebaceous glands, and most studies on this neoplasm have been conducted in Caucasians. We retrospectively reviewed the records of 29 patients with SC (16 extraocular and 13 ocular lesions) who were diagnosed from 2001 to 2014 to analyze the clinical and histopathological features of SC in the Korean population. Sixteen of the patients were women and 13 were men. There was an equal sex distribution for extraocular lesions, and a female predilection (M:F = 1:1...
August 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28658793/mucoepidermoid-carcinoma-of-salivary-gland-limitations-and-pitfalls-on-fna
#4
Geetha Vasudevan, Arijit Bishnu, Brij Mohan Kumar Singh, Varun Kumar Singh
Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Fourteen cases of suspected MEC were evaluated cytologically followed by histopathological examination for confirmation. A definite cytological diagnosis was rendered in nine cases; three of the remaining five were underdiagnosed as abscess, pleomorphic adenoma and mucus cyst...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28633738/sebaceous-carcinoma-on-the-arm-of-a-10-year-old-girl
#5
Stephen K Stacey, Tyler A Moss, Todd T Kobayashi
We report a case of a 10 year-old girl diagnosed with sebaceous carcinoma of the posterior left arm. The presented case reviews the histopathological and immunohistochemical characteristics of this malignancy, including a review of the literature in pediatric patients regarding prognosis and treatment. Sebaceous carcinoma is a malignant neoplasm with sebaceous differentiation, typically occurring in the sixth-to-seventh decades of life. It most commonly arises in the periocular region. It is extremely rare in the pediatric population...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28503344/adnexal-tumors-of-skin-an-experience-at-a-tertiary-care-center-at-delhi
#6
M Pujani, G B Madaan, Z S Jairajpuri, S Jetley, M J Hassan, S Khan
BACKGROUND: Adnexal skin tumors are a heterogeneous group of uncommon tumors usually misdiagnosed clinically due to a huge variety of types and their variants. Histopathology usually helps in establishing the diagnosis. AIMS: The study was undertaken to analyze the morphological, clinical, and histological features of adnexal tumors (ATs) of the skin at our center over a period of 4 years. SUBJECTS AND METHODS: retrospective study was conducted over a period of 4 years (April 2010-March 2014), comprising 25 ATs of skin diagnosed in the Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28394798/sox10-and-dog1-expression-in-primary-adnexal-tumors-of-the-skin
#7
Cecilia Lezcano, Jonhan Ho, Raja R Seethala
Primary skin adnexal tumors can be challenging to classify and must be discerned from cutaneous adenocarcinoma metastases from various sites. We evaluated expression of Sox10 and DOG1 in normal cutaneous adnexa and in 194 primary skin adnexal tumors, and compared their performance in discriminating primary skin adnexal tumors from cutaneous metastatic adenocarcinomas with that of p40 and p63. In normal skin adnexa, we noted Sox10 expression in both the secretory and myoepithelial cells in eccrine glands, but only in myoepithelial cells in apocrine glands...
March 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28323779/gata3-and-myb-expression-in-cutaneous-adnexal-neoplasms
#8
Joana Pardal, Uma Sundram, M Angelica Selim, Mai P Hoang
Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28323778/squared-off-nuclei-and-appliqu%C3%A3-pattern-as-a-histopathological-clue-to-periocular-sebaceous-carcinoma-a-clinicopathological-study-of-50-neoplasms-from-46-patients
#9
Sigrid M C Broekaert, Katharina Flux, Liubov Kyrpychova, Denisa Kacerovska, Doina Ivan, Michael P Schön, Philipp Ströbel, Michal Michal, Natalja Denisjuk, Katrin Kerl, Dmitry V Kazakov
The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28323777/msh6-past-and-present-and-muir-torre-syndrome-connecting-the-dots
#10
REVIEW
Meera Mahalingam
Sebaceous neoplasms such as adenoma, sebaceoma, and carcinoma, although sporadic in their occurrence, are clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous neoplasms and/or keratoacanthomas and visceral malignancies. MTS is usually the result of germline mutations in the DNA mismatch repair genes MSH2 and, albeit less commonly, MLH1. Although less know, MSH6 is yet another key player...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28300931/squamous-cell-carcinoma-arising-in-a-multiple-verrucous-epidermal-nevus
#11
Samira Yarak, Taila Yuri Siqueira Machado, Marilia Marufuji Ogawa, Mirian Luzia da Silva Almeida, Milvia Maria Simões E Silva Enokihara, Adriana Maria Porro
Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. We report a case of well-differentiated invasive squamous cell carcinoma arising from a multiple verrucous epidermal nevus. Although there is no consensus on prophylactic removal of epidermal nevus, its removal and biopsy should be considered if changes occur...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28284233/retrospective-study-of-rare-cutaneous-malignant-adnexal-tumors-of-the-head-and-neck-in-a-tertiary-care-cancer-hospital-a-case-series
#12
Omer Waqas, Muhammad Faisal, Irfan Haider, Awais Amjad, Arif Jamshed, Raza Hussain
BACKGROUND: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease...
March 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28272654/multiple-pigmented-seborrheic-keratosis-with-sebaceous-differentiation-a-case-report
#13
R Vimal Chander, P Jajaganesh, Ganthimathy Sekhar, S Chitra
Seborrheic keratosis is a benign lesion that is common in the trunk and head and neck regions. It shows a considerable variety of histological appearances leading to different variants. The presence of sebaceous differentiation in seborrheic keratosis is very rare and can histologically mimic benign and malignant tumors with sebaceous differentiation. We present a case of a 65-year-old male presenting with multiple nodules over the right and left sides of neck and the right preauricular region, histopathological examination of which revealed multiple pigmented seborrheic keratoses with sebaceous differentiation...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28256768/topics-in-histopathology-of-sweat-gland-and-sebaceous-neoplasms
#14
REVIEW
Shin-Ichi Ansai
This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC(+) , SMBC(-) ), CK5/6 (SGC(+) , SMBC(-) ), podoplanin (SGC(+) , SMBC(-) ) and mammaglobin (SGC(-) , SMBC(+) )...
March 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28165350/sebaceous-carcinoma-treated-with-mohs-micrographic-surgery
#15
Kimberly L Brady, Eva A Hurst
BACKGROUND: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality. OBJECTIVE: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches. PATIENTS AND METHODS/MATERIALS: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28120777/muir-torre-syndrome-caused-by-exonic-deletion-of-mlh1-due-to-homologous-recombination
#16
Mirei Shiki, Tokimasa Hida, Kokichi Sugano, Rie Kaneko, Takafumi Kamiya, Akihiro Sakurai, Toshiharu Yamashita
BACKGROUND: Muir-Torre syndrome (MTS) is characterized by sebaceous neoplasms with internal malignancies and regarded as a variant of hereditary nonpolyposis colorectal cancer (HNPCC). Pathogenic variations of MTS have been identified in the MSH2, MLH1, and MSH6 genes, with the majority of variations located in MSH2. OBJECTIVES: To present an MTS patient who was the only individual with skin malignancies within a cancer-prone pedigree and to show the usefulness of RNA-based genetic analysis in the investigation of MTS...
February 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28027080/carcinoid-like-labyrinthine-pattern-in-sebaceous-neoplasms-represents-a-sebaceous-mantle-phenotype-immunohistochemical-analysis-of-aberrant-vimentin-expression-and-cytokeratin-20-positive-merkel-cell-distribution
#17
Keisuke Goto, Takashi Anan, Takaya Fukumoto, Tetsunori Kimura, Noriyuki Misago
This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27919252/neoplastic-diseases-in-the-domestic-ferret-mustela-putorius-furo-in-italy-classification-and-tissue-distribution-of-856-cases-2000-2010
#18
Giancarlo Avallone, Annalisa Forlani, Marco Tecilla, Elena Riccardi, Sara Belluco, Sara Francesca Santagostino, Guido Grilli, Kiumars Khadivi, Paola Roccabianca
BACKGROUND: The aim of this study was to describe the prevalence and tissue distribution of neoplasms in Italian ferrets, compared to the epidemiological data previously reported in USA and Japan. METHODS: Signalment and diagnoses of pathological submissions received between 2000 and 2010 were searched; cases with the diagnosis of neoplasm were selected and original sections reviewed to confirm the diagnosis. RESULTS: Nine-hundred and ten samples were retrieved, 690 of which included at least one tumour for a total of 856 tumours...
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27822395/generational-expression-of-muir-torre-syndrome-in-a-canadian-family
#19
Kaitlin Alexandra Vanderbeck, R Gary Sibbald, Nirosha Murugan
Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of a 57-year-old female patient with MTS. She has a confirmed HMSH2 mutation. Recently she presented with two nodular lesions. Histologic examination confirmed these lesions to be sebaceous neoplasms. The patient has a history of endometrial and colorectal adenocarcinoma as well as several nonspecific sebaceous lesions throughout her life...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/27771121/-muir-torre-syndrome-associated-with-waldenstrom-s-macroglobulinemia
#20
C Velter, F Bourlond, C Wettle, B Lioure, D Lipsker, C Maugard, B Cribier
BACKGROUND: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system. PATIENTS AND METHODS: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas)...
December 2016: Annales de Dermatologie et de Vénéréologie
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