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Sebaceous neoplasm

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https://www.readbyqxmd.com/read/29718441/prevalence-and-molecular-characteristics-of-dna-mismatch-repair-protein-deficient-sebaceous-neoplasms-and-keratoacanthomas-in-a-japanese-hospital-based-population
#1
Kouki Kuwabara, Okihide Suzuki, Noriyasu Chika, Kensuke Kumamoto, Toshiharu Minabe, Tomoo Fukuda, Eiichi Arai, Jun-Ichi Tamaru, Kiwamu Akagi, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida
Background: Muir-Torre syndrome (MTS) is currently considered as a clinical variant of Lynch syndrome (LS). The clinical significance of the screening of patients with MTS-associated cutaneous tumors for the identification of LS has not yet been established. In addition, the prevalence and molecular characteristics of mismatch repair (MMR) protein deficiency in such tumors has scarcely been investigated in the Japanese population. Methods: Immunohistochemistry (IHC) for MMR proteins (MLH1, MSH2, MSH6 and PMS2) was performed in formalin-fixed paraffin-embedded sections prepared from 16 sebaceous neoplasms (SNs) resected from 13 patients and 32 keratoacanthomas (KAs) resected from 31 patients at our institution between January 2005 and March 2014...
April 28, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29692465/cutaneous-metastasis-leading-to-the-diagnosis-of-carcinoma-of-the-prostate-a-rare-case-report-and-review-of-literature
#2
Pritam Sureshchandra Kataria, Pradip Piraji Kendre, Apurva Ashok Patel, Sameer Dalsaniya
Prostate adenocarcinoma is a common urologic malignant neoplasm in man. Distant cutaneous metastases (CMs) of prostate carcinoma are extremely rare with a reported incidence of 0.36% and usually they occur late. Clinically, cutaneous metastasis of prostate carcinoma can mimic other skin conditions such as cellulitis, sebaceous cyst, zosteriform lesions, telangectasias, and more, resulting in a poor recognition. Few cases of true cutaneous metastatic prostate carcinoma exist in the literature. We present a case, where the first sign of carcinoma of the prostate was CM over the anterior abdominal wall...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#3
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29607000/basaloid-follicular-hamartoma-a-case-report-and-a-novel-cosmetic-treatment
#4
Kelly Segars, Hassie Cooper, Daniel J Hogan, Richard Miller, Michael Heaphy, James Spencer
Introduction: Basaloid follicular hamartoma (BFH) is a rare, benign neoplasm of the hair follicle, characterized by multiple brown papules involving the face, scalp, and trunk. It is described by multiple clinical forms, and can present as localized or generalized. Diagnosis is made histologically via biopsy, which is important in order to distinguish BFH from basal cell carcinoma (BCC) or other malignant epithelial neoplasms. Correct diagnosis allows for the avoidance of unnecessary surgeries to remove benign lesions...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29567896/syringocystadenoma-papilliferum-and-trichoblastoma-arising-in-the-nevus-sebaceous
#5
Feifei Wang, Yatong Wu, Zhancai Zheng, Yanping Bai
Nevus sebaceous (NS) is a clinically common benign tumor and has a high potential to develop into a great diversity of neoplasms of epidermal and adnexal origins. However, it is a rare phenomenon of the coexistence in a single NS with two or more skin tumors. We report a case of a 58-year-old woman with two kinds of neoplastic proliferation including syringocystadenoma papilliferum and trichoblastoma arising in NS on the scalp.
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29477759/unusual-cystic-lesion-of-the-eyebrow-a-case-report-of-malignant-chondroid-syringoma
#6
J Chauvel-Picard, A Pierrefeu, O Harou, P Breton, N Sigaux
INTRODUCTION: Malignant chondroid syringomas, also known as cutaneous malignant mixed tumors, are rare neoplasms that most frequently occur on the torso or extremities of women. Here, we present an illustrated case of a facial malignant chondroid syringoma. MATERIALS AND METHODS: A 32-year-old female patient with no notable medical history presented with an approximately 1cm-wide, painless, palpably-mobile subcutaneous nodule, suggestive of a sebaceous cyst, just above the middle third of the right eyebrow...
February 22, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29447627/lynch-syndrome-and-muir-torre-syndrome-an-update-and-review-on-the-genetics-epidemiology-and-management-of-two-related-disorders
#7
REVIEW
Stephanie Le, Umer Ansari, Aisha Mumtaz, Kunal Malik, Parth Patel, Amanda Doyle, Amor Khachemoune
Hereditary Nonpolyposis Colorectal Cancer (HNPCC), also known as Lynch Syndrome, is an autosomal dominant, tumor predisposing disorder usuallycaused by germline mutations in mismatch repair (MMR) genes. A subset of HNPCC, Muir-Torre Syndrome (MTS) also involves MMR gene defects and is generally accepted as a variant of HNPCC. MTS is typicallycharacterized by at least one visceral malignancy and one cutaneous neoplasm of sebaceous differentiation, with or without keratoacanthomas. In either version of the disorder, nonfunctional MMR systems lead tothe loss of genomic integrity, marked commonly by mismatches in repetitive DNA sequences, resulting in microsatellite instabilities...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29436004/homeobox-transcriptional-factor-engrailed-homeobox-1-is-expressed-specifically-in-normal-and-neoplastic-sweat-gland-cells
#8
Keiko Miura, Takumi Akashi, Noboru Ando, Shinya Ayabe, Kou Kayamori, Takeshi Namiki, Yoshinobu Eishi
AIMS: A number of homeobox transcriptional factors are utilised as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is expressed specifically in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be expressed specifically in the skin...
February 12, 2018: Histopathology
https://www.readbyqxmd.com/read/29431200/gata3-staining-in-primary-cutaneous-apocrine-cribriform-carcinoma-usefulness-to-differentiate-it-from-breast-cancer-metastasis
#9
Mar Llamas-Velasco, Yosmar C Pérez-Gónzalez, Esteban Daudén, Arno Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. OBJECTIVE: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test its usefulness to differentiate this tumor from metastatic breast cancer...
May 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29333623/evaluation-of-universal-immunohistochemical-screening-of-sebaceous-neoplasms-in-a-service-setting
#10
K Schon, E Rytina, J Drummond, J Simmonds, S Abbs, R Sandford, M Tischkowitz
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies. AIM: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting...
January 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29279595/pseudomyogenic-epithelioid-sarcoma-like-hemangioendothelioma-a-rare-vascular-neoplasm-with-deceptive-morphology-and-distinctive-immunophenotype
#11
F F Cheo, K Sittampalam
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a rare, low grade vascular (endothelial) neoplasm typically presenting as multicentric, superficial to deep nodules in extremities with a slight tendency of affecting young adult males. We report a case of pseudomyogenic hemangioendothelioma in a 15-year-old boy presenting initially with a 1 cm right thigh painless cutaneous lump. The lump was excised with the clinical impression of a sebaceous cyst. On microscopy, a poorly circumscribed, mild to moderately atypical spindle cell lesion in fascicular and storiform patterns with strikingly myoid-like eosinophilic cytoplasm was identified...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29274041/intraoral-pigmented-low-grade-adenocarcinoma-not-otherwise-specified-case-report-and-immunohistochemical-study
#12
Jessica Luana Dos Santos, Albina Messias de Almeida Milani Altemani, Alexandre Elias Trivellato, Cássio Edvard Sverzut, Luciana Yamamoto Almeida, Lucas Ribeiro Teixeira, Alfredo Ribeiro-Silva, Jorge Esquiche León
Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29169626/intra-oral-sebaceous-gland-tumours-in-two-dogs
#13
D-M Go, S-H Lee, S-H Woo, D-Y Kim
A 12-year-old female miniature schnauzer and a 12-year-old neutered female cocker spaniel each had a grey-yellow nodular lesion arising from the gingiva. Microscopical examination showed that both nodules were composed of varied proportions of sebocytes and basal-type reserve cells with few ducts lined by stratified squamous epithelium. Based on the histopathological findings, the cases were diagnosed as sebaceous adenoma and sebaceous epithelioma, respectively. In man, the occurrence of sebaceous neoplasms in the oral cavity has been reported to some extent, but these lesions are very rare in animals...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29093237/basal-cell-carcinoma-of-vermilion-mucosa-of-upper-lip-a-rare-case-report
#14
Reza Yaghoobi, Nastaran Ranjbari, Nader Pazyar, Maryam Foroozan, Amir Feily
Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29078997/sebaceous-lesions-of-the-skin
#15
REVIEW
Jean Iacobelli, Nathan Tobias Harvey, Benjamin Andrew Wood
Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Sebaceous changes can also be a component of benign cystic lesions or epidermal tumours, and sebaceous hyperplasia is commonly encountered. This review is intended to provide an overview of the cutaneous lesions with sebaceous differentiation, with a particular emphasis on facilitating histological diagnosis of neoplasms...
October 24, 2017: Pathology
https://www.readbyqxmd.com/read/29072946/histologic-mimics-of-basal-cell-carcinoma
#16
REVIEW
Lauren M Stanoszek, Grace Y Wang, Paul W Harms
CONTEXT: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma...
November 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29034129/sebaceous-carcinoma-in-situ-as-a-concept-and-diagnostic-entity
#17
Miglena K Komforti, Masoud Asgari, Sheng Chen
Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma in situ as a valid concept and diagnostic entity via critical literature review and histopathological assessment and illustration...
July 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28988763/treatment-of-malignant-cutaneous-adnexal-neoplasms
#18
C Bernárdez, L Requena
Malignant cutaneous adnexal neoplasms form a group of rare, typically low-grade-malignancy carcinomas with follicular, sebaceous, apocrine, or eccrine differentiation or a combination of the first 3 subtypes. Their clinical presentation is usually unremarkable, and biopsy is required to establish the differentiation subtype and the definitive diagnosis. Due to their rarity, no clear consensus has been reached on which treatment is most effective. Mohs micrographic surgery is considered to be the best option to prevent recurrence in the majority of patients...
January 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28913303/simultaneous-development-of-three-different-neoplasms-of-trichilemmoma-desmoplastic-trichilemmoma-and-basal-cell-carcinoma-arising-from-nevus-sebaceus
#19
Chi An Lee, Seok Joo Kang, Seong Pin Jeon, Hook Sun, Mi Seon Kang
Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. A 61-year-old male patient was admitted to our hospital for a 4 cm×2.5 cm growing tumor in a verrucous form arising within a periauricular nevus sebaceus in the post auricle of the left ear that had developed 30 years earlier...
March 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/28873247/evaluation-and-comparison-of-staining-patterns-of-factor-xiiia-ac-1a1-adipophilin-and-gata3-in-sebaceous-neoplasia
#20
Brian J Tjarks, Brandy R Pownell, Claire Evans, Paul A Thompson, Amy M Kerkvliet, Michael R D Koch, Ali D Jassim
BACKGROUND: Reliable nuclear immunohistochemical stains for sebaceous neoplasms have not been readily available. Positive nuclear staining has been reported for GATA3 and factor XIIIa (AC-1A1). We sought to determine the diagnostic utility of these nuclear stains by comparing their staining pattern to adipophilin, a consistently positive cytoplasmic stain. METHODS: Cases with the diagnosis of sebaceous hyperplasia, sebaceous adenoma, sebaceous epithelioma/sebaceoma, sebaceous carcinoma, and nonsebaceous neoplasms (basal cell carcinoma and squamous cell carcinoma) were examined...
January 2018: Journal of Cutaneous Pathology
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