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IRX3 obesity

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https://www.readbyqxmd.com/read/29736189/investigation-of-the-influence-of-high-glucose-on-molecular-and-genetic-responses-an-in-vitro-study-using-a-human-intestine-model
#1
Tugce Boztepe, Sukru Gulec
Background: Dietary glucose consumption has increased worldwide. Long-term high glucose intake contributes to the development of obesity and type 2 diabetes mellitus (T2DM). Obese people tend to eat glucose-containing foods, which can lead to an addiction to glucose, increased glucose levels in the blood and intestine lumen, and exposure of intestinal enterocytes to high dietary glucose. Recent studies have documented a role for enterocytes in glucose sensing. However, the molecular and genetic relationship between high glucose levels and intestinal enterocytes has not been determined...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29658457/-association-between-copy-number-variations-and-risk-of-overweight-obesity-among-han-uyghur-and-kazak-children
#2
Abidan Ainiwaer, Adalibieke Adalibieke, Bing-Xue Huang, Y E Yekejiergeli, Ya-Lan Dou, Jie Wu, Jiang-Hong Dai
OBJECTIVE: To study the association between the prevalence of overweight/obesity and copy number variations (CNVs) among Han, Uyghur, and Kazak children in Xinjiang, China. METHODS: The kindergartens in Ili, Altay, and Karamay in Xinjiang were selected as research sites, and stratified cluster sampling was used to select the children aged 3-7 years. Body height and body weight were measured, and exfoliated buccal mucosa cells were collected. CNVplex® was used to measure the CNVs of FTO_1, IRX3_1, IRX3_2, MC4R_1, and MC4R_2...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29346763/derepression-of-the-iroquois-homeodomain-transcription-factor-gene-irx3-confers-differentiation-block-in-acute-leukemia
#3
Tim D D Somerville, Fabrizio Simeoni, John A Chadwick, Emma L Williams, Gary J Spencer, Katalin Boros, Christopher Wirth, Eleni Tholouli, Richard J Byers, Tim C P Somervaille
The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify obesity risk in humans. We now report a functional role for IRX3 in human acute leukemia. Although transcript levels are very low in normal human bone marrow cells, high IRX3 expression is found in ∼30% of patients with acute myeloid leukemia (AML), ∼50% with T-acute lymphoblastic leukemia, and ∼20% with B-acute lymphoblastic leukemia, frequently in association with high-level HOXA gene expression...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29220587/fto-gene-affects-obesity-and-breast-cancer-through-similar-mechanisms-a-new-insight-into-the-molecular-therapeutic-targets
#4
M E Akbari, M Gholamalizadeh, S Doaei, F Mirsafa
OBJECTIVES: This review focused on the possible mediatory role of the FTO in the association between obesity and breast cancer. METHOD: All articles published in English from June 1990 to January 2017 were studied. The search terms used were FTO gene, FTO polymorphism, breast cancer, and obesity. Inclusion criteria consisted of assessment of the relationship between FTO polymorphisms and/or FTO expression level with obesity and/or breast cancer as a primary outcome...
January 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/28988979/irx3-promotes-the-browning-of-white-adipocytes-and-its-rare-variants-are-associated-with-human-obesity-risk
#5
Yaoyu Zou, Peng Lu, Juan Shi, Wen Liu, Minglan Yang, Shaoqian Zhao, Na Chen, Maopei Chen, Yingkai Sun, Aibo Gao, Qingbo Chen, Zhiguo Zhang, Qinyun Ma, Tinglu Ning, Xiayang Ying, Jiabin Jin, Xiaxing Deng, Baiyong Shen, Yifei Zhang, Bo Yuan, Sophie Kauderer, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning, Weiqing Wang, Weiqiong Gu, Jiqiu Wang
BACKGROUND: IRX3 was recently reported as the effector of the FTO variants. We aimed to test IRX3's roles in the browning program and to evaluate the association between the genetic variants in IRX3 and human obesity. METHODS: IRX3 expression was examined in beige adipocytes in human and mouse models, and further validated in induced beige adipocytes. The browning capacity of primary preadipocytes was assessed with IRX3 knockdown. Luciferase reporter analysis and ChIP assay were applied to investigate IRX3's effects on UCP1 transcriptional activity...
October 2017: EBioMedicine
https://www.readbyqxmd.com/read/28967609/regulations-of-adipocyte-phenotype-and-obesity-by-irx3-positive-or-negative
#6
Takeshi Inagaki
No abstract text is available yet for this article.
October 2017: EBioMedicine
https://www.readbyqxmd.com/read/28859657/fto-associations-with-obesity-and-telomere-length
#7
REVIEW
Yuling Zhou, Brett D Hambly, Craig S McLachlan
This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO in the regulation of methylation status as possible regulators of weight gain and genetic aging. We present a theoretical review of the FTO gene with a particular emphasis on associations with UCP2, AMPK, RBL2, IRX3, CUX1, mTORC1 and hormones involved in hunger regulation. These associations are important for dietary behavior regulation and cellular nutrient sensing via amino acids...
September 1, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28662178/genetic-association-of-fto-irx-region-with-obesity-and-overweight-in-the-polish-population
#8
Marta Sobalska-Kwapis, Aleksandra Suchanecka, Marcin Słomka, Anna Siewierska-Górska, Ewa Kępka, Dominik Strapagiel
BACKGROUND/OBJECTIVES: Genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI) in many different populations. Variants in the FTO locus are reported to be one of the strongest genetic predictors of obesity. Recent publications pointed also to a topologically associated domain (TAD) which is identified as a novel region affecting BMI. The TAD area encompasses the IRXB cluster (IRX3, IRX5, IRX6), FTO and RPGRIP1L genes. SUBJECTS/METHODS: In this study, we investigated the relationship between variation of the FTO and IRX genes and obesity in Poles...
2017: PloS One
https://www.readbyqxmd.com/read/28539834/complex-relationship-between-obesity-and-the-fat-mass-and-obesity-locus
#9
REVIEW
Qingyun Yang, Tiancun Xiao, Jiao Guo, Zhengquan Su
In the 21st century, obesity has become a serious problem because of increasing obese patients and numerous metabolic complications. The primary reasons for this situation are environmental and genetic factors. In 2007, FTO (fat mass and obesity associated) was the first gene identified through a genome-wide association study (GWAS) associated with obesity in humans. Subsequently, a cluster of single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene was discovered to be associated with BMI and body composition...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28316138/irx3-is-a-genetic-modifier-for-birth-weight-adolescent-obesity-and-transaminase-metabolism
#10
C Liu, C Chu, J Zhang, D Wu, D Xu, P Li, Y Chen, B Liu, L Pei, L Zhang, S Liu, T Qi, X-Y Lou, L Li
OBJECTIVE: IRX3 expression has been functionally associated in obesity-associated long-distance susceptibility loci, but the effect of the IRX3 genetic variants on human obesity and obesity-related metabolism remains uncertain. METHODS: To determine the genetic role of IRX3, we conducted a molecular epidemiological analysis using three haplotype tagging single nucleotide polymorphisms (SNPs; rs8053360, rs3751723 and rs12445085) and one nonsynonymous SNP (rs1126960) at the IRX3 locus in 333 junior and senior high school students from a northeast Chinese population...
March 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/28179100/nutrition-modulates-fto-and-irx3-gene-transcript-levels-but-does-not-alter-their-dna-methylation-profiles-in-rat-white-adipose-tissues
#11
Joanna Nowacka-Woszuk, Ewa Pruszynska-Oszmalek, Maciej Szydlowski, Izabela Szczerbal
The fat mass and obesity associated (Fto) and iroquois homeobox 3 (Irx3) genes have been recognised as important obesity-related genes. Studies on the expression of these genes in the fat tissue of human and mouse have produced inconsistent results, while similar data on rat are limited. Environmental factors such as diet, should be considered as potential modulators of gene transcript levels through epigenetic mechanisms including DNA methylation. The aim of this study was to evaluate transcription levels and DNA methylation profiles of rat Fto and Irx3 genes in two white adipose tissue depots in response to high-fat and high-protein diets...
April 30, 2017: Gene
https://www.readbyqxmd.com/read/27650258/a-multianalytical-approach-to-evaluate-the-association-of-55-snps-in-28-genes-with-obesity-risk-in-north-indian-adults
#12
Apurva Srivastava, Balraj Mittal, Jai Prakash, Pranjal Srivastava, Nimisha Srivastava, Neena Srivastava
OBJECTIVES: The aim of the study was to investigate the association of 55 SNPs in 28 genes with obesity risk in a North Indian population using a multianalytical approach. METHODS: Overall, 480 subjects from the North Indian population were studied using strict inclusion/exclusion criteria. SNP Genotyping was carried out by Sequenom Mass ARRAY platform (Sequenom, San Diego, CA) and validated Taqman® allelic discrimination (Applied Biosystems® ). Statistical analyses were performed using SPSS software version 19...
March 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27560134/fto-obesity-risk-variants-are-linked-to-adipocyte-irx3-expression-and-bmi-of-children-relevance-of-fto-variants-to-defend-body-weight-in-lean-children
#13
Kathrin Landgraf, Markus Scholz, Peter Kovacs, Wieland Kiess, Antje Körner
BACKGROUND: Genome-wide association studies have identified variants within the FTO (fat mass and obesity associated) locus as the strongest predictors of obesity amongst all obesity-associated gene loci. Recent evidence suggests that variants in FTO directly affect human adipocyte function through targeting IRX3 and IRX5 and thermogenesis regulation. AIM: We addressed the relevance of this proposed FTO-IRX pathway in adipose tissue (AT) of children. RESULTS: Expression of IRX3 was higher in adipocytes compared to SVF...
2016: PloS One
https://www.readbyqxmd.com/read/27390851/important-role-of-fto-in-the-survival-of-rare-panresistant-triple-negative-inflammatory-breast-cancer-cells-facing-a-severe-metabolic-challenge
#14
Balraj Singh, Hannah E Kinne, Ryan D Milligan, Laura J Washburn, Mark Olsen, Anthony Lucci
We have previously shown that only 0.01% cells survive a metabolic challenge involving lack of glutamine in culture medium of SUM149 triple-negative Inflammatory Breast Cancer cell line. These cells, designated as SUM149-MA for metabolic adaptability, are resistant to chemotherapeutic drugs, and they efficiently metastasize to multiple organs in nude mice. We hypothesized that obesity-related molecular networks, which normally help in cellular and organismal survival under metabolic challenges, may help in the survival of MA cells...
2016: PloS One
https://www.readbyqxmd.com/read/27064284/hypomorphism-of-fto-and-rpgrip1l-causes-obesity-in-mice
#15
George Stratigopoulos, Lisa Cole Burnett, Richard Rausch, Richard Gill, David Barth Penn, Alicja A Skowronski, Charles A LeDuc, Anthony J Lanzano, Pumin Zhang, Daniel R Storm, Dieter Egli, Rudolph L Leibel
Noncoding polymorphisms in the fat mass and obesity-associated (FTO) gene represent common alleles that are strongly associated with effects on food intake and adiposity in humans. Previous studies have suggested that the obesity-risk allele rs8050136 in the first intron of FTO alters a regulatory element recognized by the transcription factor CUX1, thereby leading to decreased expression of FTO and retinitis pigmentosa GTPase regulator-interacting protein-1 like (RPGRIP1L). Here, we evaluated the effects of rs8050136 and another potential CUX1 element in rs1421085 on expression of nearby genes in human induced pluripotent stem cell-derived (iPSC-derived) neurons...
May 2, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26642925/complete-re-sequencing-of-a-2mb-topological-domain-encompassing-the-fto-irxb-genes-identifies-a-novel-obesity-associated-region-upstream-of-irx5
#16
Lilian E Hunt, Boris Noyvert, Leena Bhaw-Rosun, Abdul K Sesay, Lavinia Paternoster, Ellen A Nohr, George Davey Smith, Niels Tommerup, Thorkild I A Sørensen, Greg Elgar
BACKGROUND: Association studies have identified a number of loci that contribute to an increased body mass index (BMI), the strongest of which is in the first intron of the FTO gene on human chromosome 16q12.2. However, this region is both non-coding and under strong linkage disequilibrium, making it recalcitrant to functional interpretation. Furthermore, the FTO gene is located within a complex cis-regulatory landscape defined by a topologically associated domain that includes the IRXB gene cluster, a trio of developmental regulators...
December 7, 2015: Genome Medicine
https://www.readbyqxmd.com/read/26627093/the-fat-mass-and-obesity-related-fto-gene-mechanisms-of-impact-on-obesity-and-energy-balance
#17
REVIEW
John R Speakman
A cluster of single nucleotide polymorphisms (SNPs) in the first intron of the fat mass and obesity related (FTO) gene were the first common variants discovered to be associated with body mass index and body fatness. This review summarises what has been later discovered about the biology of FTO drawing together information from both human and animal studies. Subsequent work showed that the 'at risk' alleles of these SNPs are associated with greater food intake and increased hunger/lowered satiety, but are not associated with altered resting energy expenditure or low physical activity in humans...
March 2015: Current Obesity Reports
https://www.readbyqxmd.com/read/26531891/catalpol-preserves-neural-function-and-attenuates-the-pathology-of-alzheimer-s-disease-in-mice
#18
Jin-Zhong Huang, Jian Wu, Shoukui Xiang, Shiying Sheng, Ying Jiang, Zhilong Yang, Fei Hua
Alzheimer's disease (AD) is the most common form of dementia and there currently are no effective treatment strategies available. Catalpol is an iridoid glucoside, and large quantities can be isolated from the genus Rehmannia (Orobanchaceae). The present study assessed whether catalpol had any protective effects against Alzheimer's disease using a murine model. Reactive oxygen species (ROS)-associated enzymes as well as soluble Aβ40 and Aβ42 were detected using kits. Thioflavin‑S staining was performed to detect senile plaques and reverse-transcription quantitative polymerase chain reaction was used to assess iroquois homeobox protein 3 (IRX3) and obesity‑associated genes, while western blot analysis was used for β‑secretase 1 (BACE1), insulin‑degrading enzyme (IDE) and neprilysin (NEP) detection...
January 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26440677/association-of-fto-and-irx3-genetic-variants-to-obesity-risk-in-north-india
#19
Apurva Srivastava, Balraj Mittal, Jai Prakash, Pranjal Srivastava, Nimisha Srivastava, Neena Srivastava
BACKGROUND: Obesity is an increasingly important health problem worldwide as well as in developing countries like India. Recent genetic studies suggest that obesity associated FTO and IRX3 are functionally linked and many effects due to genetic variants in FTO gene act through IRX3. AIM: To evaluate the association of FTO and IRX3 genetic variants towards obesity risk. SUBJECTS AND METHODS: North Indian individuals categorised as non-obese (BMI < 30 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)) were selected...
September 2016: Annals of Human Biology
https://www.readbyqxmd.com/read/26340902/scrutinizing-the-fto-locus-compelling-evidence-for-a-complex-long-range-regulatory-context
#20
Mathias Rask-Andersen, Markus Sällman Almén, Helgi B Schiöth
Single nucleotide polymorphisms (SNPs) within a genetic region including the first two introns of the gene encoding FTO have consistently been shown to be the strongest genetic factors influencing body mass index (BMI). However, this same also contains several regulatory DNA elements that affect the expression of IRX3 and IRX5, which respectively, are located approximately 500 kb and 1.2 Mbp downstream from the BMI-associated FTO locus. Through these affected regulatory elements, genetic variation at the FTO locus influences adipocyte development leading to decreased thermogenesis and increased lipid storage...
November 2015: Human Genetics
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