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https://www.readbyqxmd.com/read/28727822/dna-methylation-of-candidate-genes-in-peripheral-blood-from-patients-with-type-2-diabetes-or-the-metabolic-syndrome
#1
Sanne D van Otterdijk, Alexandra M Binder, Katarzyna Szarc Vel Szic, Julia Schwald, Karin B Michels
INTRODUCTION: The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is increasing and several studies suggested an involvement of DNA methylation in the development of these metabolic diseases. This study was designed to investigate if differential DNA methylation in blood can function as a biomarker for T2D and/or MetS. METHODS: Pyrosequencing analyses were performed for the candidate genes KCNJ11, PPARγ, PDK4, KCNQ1, SCD1, PDX1, FTO and PEG3 in peripheral blood leukocytes (PBLs) from 25 patients diagnosed with only T2D, 9 patients diagnosed with T2D and MetS and 11 control subjects without any metabolic disorders...
2017: PloS One
https://www.readbyqxmd.com/read/28724990/large-meta-analysis-of-genome-wide-association-studies-identifies-five-loci-for-lean-body-mass
#2
M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller, Zoltán Kutalik, Jian'an Luan, Ida Malkin, Janina S Ried, Albert V Smith, Gudmar Thorleifsson, Liesbeth Vandenput, Jing Hua Zhao, Weihua Zhang, Ali Aghdassi, Kristina Åkesson, Najaf Amin, Leslie J Baier, Inês Barroso, David A Bennett, Lars Bertram, Rainer Biffar, Murielle Bochud, Michael Boehnke, Ingrid B Borecki, Aron S Buchman, Liisa Byberg, Harry Campbell, Natalia Campos Obanda, Jane A Cauley, Peggy M Cawthon, Henna Cederberg, Zhao Chen, Nam H Cho, Hyung Jin Choi, Melina Claussnitzer, Francis Collins, Steven R Cummings, Philip L De Jager, Ilja Demuth, Rosalie A M Dhonukshe-Rutten, Luda Diatchenko, Gudny Eiriksdottir, Anke W Enneman, Mike Erdos, Johan G Eriksson, Joel Eriksson, Karol Estrada, Daniel S Evans, Mary F Feitosa, Mao Fu, Melissa Garcia, Christian Gieger, Thomas Girke, Nicole L Glazer, Harald Grallert, Jagvir Grewal, Bok-Ghee Han, Robert L Hanson, Caroline Hayward, Albert Hofman, Eric P Hoffman, Georg Homuth, Wen-Chi Hsueh, Monica J Hubal, Alan Hubbard, Kim M Huffman, Lise B Husted, Thomas Illig, Erik Ingelsson, Till Ittermann, John-Olov Jansson, Joanne M Jordan, Antti Jula, Magnus Karlsson, Kay-Tee Khaw, Tuomas O Kilpeläinen, Norman Klopp, Jacqueline S L Kloth, Heikki A Koistinen, William E Kraus, Stephen Kritchevsky, Teemu Kuulasmaa, Johanna Kuusisto, Markku Laakso, Jari Lahti, Thomas Lang, Bente L Langdahl, Lenore J Launer, Jong-Young Lee, Markus M Lerch, Joshua R Lewis, Lars Lind, Cecilia Lindgren, Yongmei Liu, Tian Liu, Youfang Liu, Östen Ljunggren, Mattias Lorentzon, Robert N Luben, William Maixner, Fiona E McGuigan, Carolina Medina-Gomez, Thomas Meitinger, Håkan Melhus, Dan Mellström, Simon Melov, Karl Michaëlsson, Braxton D Mitchell, Andrew P Morris, Leif Mosekilde, Anne Newman, Carrie M Nielson, Jeffrey R O'Connell, Ben A Oostra, Eric S Orwoll, Aarno Palotie, Stephan Parker, Munro Peacock, Markus Perola, Annette Peters, Ozren Polasek, Richard L Prince, Katri Räikkönen, Stuart H Ralston, Samuli Ripatti, John A Robbins, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Suzanne Satterfield, Eric E Schadt, Sabine Schipf, Laura Scott, Joban Sehmi, Jian Shen, Chan Soo Shin, Gunnar Sigurdsson, Shad Smith, Nicole Soranzo, Alena Stančáková, Elisabeth Steinhagen-Thiessen, Elizabeth A Streeten, Unnur Styrkarsdottir, Karin M A Swart, Sian-Tsung Tan, Mark A Tarnopolsky, Patricia Thompson, Cynthia A Thomson, Unnur Thorsteinsdottir, Emmi Tikkanen, Gregory J Tranah, Jaakko Tuomilehto, Natasja M van Schoor, Arjun Verma, Peter Vollenweider, Henry Völzke, Jean Wactawski-Wende, Mark Walker, Michael N Weedon, Ryan Welch, H-Erich Wichman, Elisabeth Widen, Frances M K Williams, James F Wilson, Nicole C Wright, Weijia Xie, Lei Yu, Yanhua Zhou, John C Chambers, Angela Döring, Cornelia M van Duijn, Michael J Econs, Vilmundur Gudnason, Jaspal S Kooner, Bruce M Psaty, Timothy D Spector, Kari Stefansson, Fernando Rivadeneira, André G Uitterlinden, Nicholas J Wareham, Vicky Ossowski, Dawn Waterworth, Ruth J F Loos, David Karasik, Tamara B Harris, Claes Ohlsson, Douglas P Kiel
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28720844/highly-efficient-non-enzymatic-glucose-sensor-based-on-cuo-modified-vertically-grown-zno-nanorods-on-electrode
#3
Rafiq Ahmad, Nirmalya Tripathy, Min-Sang Ahn, Kiesar Sideeq Bhat, Tahmineh Mahmoudi, Yousheng Wang, Jin-Young Yoo, Dae-Wook Kwon, Hwa-Young Yang, Yoon-Bong Hahn
There is a major challenge to attach nanostructures on to the electrode surface while retaining their engineered morphology, high surface area, physiochemical features for promising sensing applications. In this study, we have grown vertically-aligned ZnO nanorods (NRs) on fluorine doped tin oxide (FTO) electrodes and decorated with CuO to achieve high-performance non-enzymatic glucose sensor. This unique CuO-ZnO NRs hybrid provides large surface area and an easy substrate penetrable structure facilitating enhanced electrochemical features towards glucose oxidation...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717589/association-of-polymorphic-markers-of-genes-fto-kcnj11-cdkal1-slc30a8-and-cdkn2b-with-type-2-diabetes-mellitus-in-the-russian-population
#4
Aleksey G Nikitin, Viktor Y Potapov, Olga I Brovkina, Ekaterina O Koksharova, Dmitry S Khodyrev, Yury I Philippov, Marina S Michurova, Minara S Shamkhalova, Olga K Vikulova, Svetlana A Smetanina, Lyudmila A Suplotova, Irina V Kononenko, Viktor Y Kalashnikov, Olga M Smirnova, Alexander Y Mayorov, Valery V Nosikov, Alexander V Averyanov, Marina V Shestakova
BACKGROUND: The association of type 2 diabetes mellitus (T2DM) with the KCNJ11, CDKAL1, SLC30A8, CDKN2B, and FTO genes in the Russian population has not been well studied. In this study, we analysed the population frequencies of polymorphic markers of these genes. METHODS: The study included 862 patients with T2DM and 443 control subjects of Russian origin. All subjects were genotyped for 10 single nucleotide polymorphisms (SNPs) of the genes using real-time PCR (TaqMan assays)...
2017: PeerJ
https://www.readbyqxmd.com/read/28715369/electrospinning-of-photocatalytic-electrodes-for-dye-sensitized-solar-cells
#5
Nicolò Canever, Fraser Hughson, Thomas J Macdonald, Thomas Nann
This work demonstrates a protocol to fabricate a fiber-based photoanode for dye-sensitized solar cells, consisting of a light-scattering layer made of electrospun titanium dioxide nanofibers (TiO2-NFs) on top of a blocking layer made of commercially available titanium dioxide nanoparticles (TiO2-NPs). This is achieved by first electrospinning a solution of titanium (IV) butoxide, polyvinylpyrrolidone (PVP), and glacial acetic acid in ethanol to obtain composite PVP/TiO2 nanofibers. These are then calcined at 500 °C to remove the PVP and to obtain pure anatase-phase titania nanofibers...
June 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28712975/fto-genotype-and-weight-status-among-preadolescents-assessing-the-mediating-effects-of-obesogenic-appetitive-traits
#6
Jennifer A Emond, Alison Tovar, Zhigang Li, Reina K Lansigan, Diane Gilbert-Diamond
Polymorphisms in the Fat Mass and Obesity Associated (FTO) gene are robustly associated with overweight and obesity among children, although the underlying mechanisms are poorly understood. We tested if appetitive traits partially mediated the association between FTO genotype and increased BMI among a sample of US preadolescents. Data were from 178 unrelated 9-10 year olds who participated in an experimental study between 2013 and 2015. Children's DNA was isolated from buccal swabs, and the rs9939609 SNP in the FTO gene was genotyped...
July 13, 2017: Appetite
https://www.readbyqxmd.com/read/28700216/accelerated-lifetime-testing-of-organic-inorganic-perovskite-solar-cells-encapsulated-by-low-cost-polyisobutylene
#7
Lei Shi, Trevor L Young, Jincheol Kim, Yun Sheng, Lei Wang, Yifeng Chen, Zhiqiang Feng, Mark Keevers, Xiaojing Hao, Pierre Verlinden, Martin A Green, Anita W Y Ho-Baillie
Metal halide perovskite solar cells (PSCs) have undergone rapid progress. However, unstable performance caused by sensitivity to environmental moisture and high temperature is a major impediment to commercialisation of PSCs. In the present work, a low temperature, glass-glass encapsulation technique using polyisobutylene (PIB) as the moisture barrier is investigated on planar glass/FTO/TiO2/FAPbI3/PTAA/gold perovskite solar cells. PIB was applied as either an edge seal or blanket layer. Electrical connections to the encapsulated PSCs were provided by either the FTO or Au layers...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28700209/silicotungstate-a-potential-electron-transporting-layer-for-low-temperature-perovskite-solar-cells
#8
Yoon Ho Choi, Hyun Bin Kim, In Seok Yang, Sang Do Sung, Young Sik Choi, Jeongho Kim, Wan In Lee
Thin films of a heteropolytungstate, lithium silicotungstate (Li4SiW12O40, termed Li-ST), prepared by a solution process at low temperature, were successfully applied as electron transporting layer (ETL) of planar-type perovskite solar cells (PSCs). Dense and uniform Li-ST films were prepared on FTO glass by depositing a thin Li-ST buffer layer, followed by coating of a main Li-ST layer. The film thickness was controlled by varying the number of coating cycles, consisting of spin-coating and thermal treatment at 150 °C...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28699988/type-2-diabetes-associated-genetic-variants-of-fto-lepr-pparg-and-tcf7l2-in-gestational-diabetes-in-a-brazilian-population
#9
Mauren Isfer Anghebem-Oliveira, Bruna Rodrigues Martins, Dayane Alberton, Edneia Amancio de Souza Ramos, Geraldo Picheth, Fabiane Gomes de Moraes Rego
Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods: 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age...
May 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28690685/examining-for-an-association-between-candidate-gene-polymorphisms-in-the-metabolic-syndrome-components-on-excess-weight-and-adiposity-measures-in-youth-a-cross-sectional-study
#10
Angélica María Muñoz, Claudia María Velásquez, Gloria María Agudelo, Rosa Magdalena Uscátegui, Alejandro Estrada, Fredy Alonso Patiño, Beatriz Elena Parra, María Victoria Parra, Gabriel Bedoya
BACKGROUND: A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate the effect of perinatal and socioeconomic factors on these associations. METHODS: The anthropometry, socioeconomic and perinatal conditions and 10 polymorphisms were evaluated in 1081 young people between 10 and 18 years old. Genotypic associations were calculated using logistic and linear models adjusted by age, gender, and pubertal maturation, and a genetic risk score (GRS) was calculated by summing the number of effect alleles...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28682711/-i-have-strong-hopes-for-the-future-time-orientations-and-resilience-among-canadian-indigenous-youth
#11
Andrew R Hatala, Tamara Pearl, Kelley Bird-Naytowhow, Andrew Judge, Erynne Sjoblom, Linda Liebenberg
In this article, we demonstrate how concepts of time and the future inform processes of resilience among Indigenous adolescents within an urban Canadian context. This study employed a modified grounded theory methodology by conducting 38 qualitative interviews with 28 Indigenous youth (ages 15-25) over the course of 1 year. The analysis revealed complex processes of and navigations between moments of distress and strategies for resilience. The distressing contexts in which Indigenous youth often find themselves can impact the development of their concepts of time and limit their abilities to conceptualize a future...
July 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28678289/rational-design-of-a-tripartite-layered-tio2-photoelectrode-a-candidate-for-enhanced-power-conversion-efficiency-in-dye-sensitized-solar-cells
#12
Javid Khan, Jiuwang Gu, Shiman He, Xiaohui Li, Gulzar Ahmed, Zhongwu Liu, Muhammad Nadeem Akhtar, Wenjie Mai, Mingmei Wu
A tri-layered photoelectrode for dye-sensitized solar cells (DSSCs) is assembled using single crystal hollow TiO2 nanoparticles (HTNPs), sub-micro hollow TiO2 mesospheres (SHTMSs) and hierarchical TiO2 microspheres (HTMSs). The bottom layer composed of single crystal hollow TiO2 nanoparticles serves to absorb dye molecules, harvest light due to its hollow structure and keep a better mechanical contact with FTO conducting glass; the middle layer consisting of sub-micro hollow mesospheres works as a multifunctional layer due to its high dye adsorption ability, strong light trapping and scattering ability and slow recombination rates; and the top layer consisting of hierarchical microspheres enhances light scattering...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28676657/stability-limits-of-tin-based-electrocatalyst-supports
#13
Simon Geiger, Olga Kasian, Andrea M Mingers, Karl J J Mayrhofer, Serhiy Cherevko
Tin-based oxides are attractive catalyst support materials considered for application in fuel cells and electrolysers. If properly doped, these oxides are relatively good conductors, assuring that ohmic drop in real applications is minimal. Corrosion of dopants, however, will lead to severe performance deterioration. The present work aims to investigate the potential dependent dissolution rates of indium tin oxide (ITO), fluorine doped tin oxide (FTO) and antimony doped tin oxide (ATO) in the broad potential window ranging from -0...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674662/bmi-prediction-within-a-korean-population
#14
Jin Sol Lee, Hyun Sub Cheong, Hyoung-Doo Shin
BACKGROUND: Body Mass Index (BMI) is widely regarded as an important clinical trait for obesity and other diseases such as Type 2 diabetes, coronary heart disease, and osteoarthritis. METHODS: This study uses 6,011 samples of genotype data from ethnic Korean subjects. The data was retrieved from the Korea Association Resource. To identify the BMI-related markers within the Korean population, we collected genome-wide association study (GWAS) markers using a GWAS catalog and also obtained other markers from nearby regions...
2017: PeerJ
https://www.readbyqxmd.com/read/28671221/a-new-preparation-of-a-bifunctional-crystalline-heterogeneous-copper-electrocatalyst-by-electrodeposition-using-a-robson-type-macrocyclic-dinuclear-copper-complex-for-efficient-hydrogen-and-oxygen-evolution-from-water
#15
Samit Majumder, Ashraf Abdel Haleem, Perumandla Nagaraju, Yoshinori Naruta
The development of low-cost, stable bifunctional electrocatalysts, which operate in the same electrolyte with a low overpotential for water splitting, including the oxygen evolution reaction and the hydrogen evolution reaction, remains an attractive prospect and a great challenge. In this study, a water soluble Robson-type macrocyclic dicopper(ii) complex has been used for the first time as a catalyst precursor for the generation of a copper-based bifunctional heterogeneous catalyst film, which can be used for both HER and OER at a near neutral pH...
July 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28670229/nudt15-fto-and-runx1-genetic-variants-and-thiopurine-intolerance-among-japanese-patients-with-inflammatory-bowel-diseases
#16
Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura
BACKGROUND/AIMS: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine. The strong associations identified between NUDT15 p.Arg139Cys and thiopurine-induced leukopenia and severe hair loss have been studied and confirmed over the last 2 years. However, other coding variants, including NUDT15 p.Val18_Val19insGlyVal, NUDT15 p.Val18Ile, and FTO p.Ala134Thr, and a noncoding variation in RUNX1 (rs2834826) remain to be examined in detail in this respect...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28662178/genetic-association-of-fto-irx-region-with-obesity-and-overweight-in-the-polish-population
#17
Marta Sobalska-Kwapis, Aleksandra Suchanecka, Marcin Słomka, Anna Siewierska-Górska, Ewa Kępka, Dominik Strapagiel
BACKGROUND/OBJECTIVES: Genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI) in many different populations. Variants in the FTO locus are reported to be one of the strongest genetic predictors of obesity. Recent publications pointed also to a topologically associated domain (TAD) which is identified as a novel region affecting BMI. The TAD area encompasses the IRXB cluster (IRX3, IRX5, IRX6), FTO and RPGRIP1L genes. SUBJECTS/METHODS: In this study, we investigated the relationship between variation of the FTO and IRX genes and obesity in Poles...
2017: PloS One
https://www.readbyqxmd.com/read/28660660/photovoltaic-rudorffites-structure-and-optoelectronic-properties
#18
Ivan Turkevych, Said Kazaoui, Eisuke Ito, Toshiyuki Urano, Koji Yamada, Hiroshi Tomiyasu, Hideo Yamagishi, Michio Kondo, Shinji Aramaki
Hybrid CPbX₃ (C=Cs, CH₃NH₃; X=Br, I) perovskites are blessed with both excellent photovoltaic properties and high toxicity that hinders their practical application. Unfortunately, all Pb-free alternatives based on Sn and Ge are extremely unstable. Although stable and non-toxic C₂ABX₆ double-perovskites based on alternating corner-shared AX₆ and BX₆ octahedra (where A=Ag, Cu; B=Bi, Sb) are possible, they have indirect and wide bandgaps of over 2 eV. However, is it necessary to keep the corner-shared perovskite structure to retain good photovoltaic properties? Here, we demonstrate another family of photovoltaic halides based on edge shared AX₆ and BX₆ octahedra with the general formula AaBbXx (x=a+3b) such as Ag₃BiI₆, Ag₂BiI₅, AgBiI₄, AgBi₂I₇...
June 28, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28659218/effect-of-dietary-consumption-as-a-modifier-on-the-association-between-fto-gene-variants-and-excess-body-weight-in-children-from-an-admixed-population-in-brazil-the-social-changes-asthma-and-allergy-in-latin-america-scaala-cohort-study
#19
Marília Vilella, Gustavo Nunes de Oliveira Costa, Maurício Lima Barreto, Camila Alexandrina Figueredo, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Sheila Maria Alvim de Matos, Rosemeire Leovigildo Fiaccone, Pablo Oliveira, Aline Rocha, Rita de Cássia Ribeiro-Silva
Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene...
June 29, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28654287/near-infrared-and-two-wavelength-electrochromism-based-on-nanocrystalline-tio2-films-functionalized-with-ruthenium-amine-conjugated-complexes
#20
Zhi-Juan Li, Jiang-Yang Shao, Yu-Wu Zhong
Two cyclometalated ruthenium complexes 2 and 4 containing a redox-active amine substituent and three carboxylic acid groups were synthesized, where the ruthenium ion and the amine site were separated by a phenyl or biphenyl bridge for 2 and 4, respectively. Nanocrystalline TiO2 films on fluorine doped SnO2 (FTO)/glass substrates anchored with 2 or 4 were prepared. These films display two consecutive anodic waves in the potential region between +0.1 and +1.0 V vs Ag/AgCl. Among four organic solvents examined, the FTO/TiO2/2 film displays the best cyclic electrochemical stability in ClCH2CH2Cl...
July 17, 2017: Inorganic Chemistry
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