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https://www.readbyqxmd.com/read/28103813/fat-mass-and-obesity-associated-fto-gene-influences-skeletal-muscle-phenotypes-in-non-resistance-trained-males-and-elite-rugby-playing-position
#1
S M Heffernan, G K Stebbings, L P Kilduff, R M Erskine, S H Day, C I Morse, J S McPhee, C J Cook, B Vance, W J Ribbans, S M Raleigh, C Roberts, M A Bennett, G Wang, M Collins, Y P Pitsiladis, A G Williams
BACKGROUND: FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes. METHODS: In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the FTO rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; n = 120), we also assessed structural and functional skeletal muscle phenotypes using dual energy x-ray absorptiometry, ultrasound and isokinetic dynamometry...
January 19, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28098978/reliable-and-low-power-multilevel-resistive-switching-in-tio2-nanorod-arrays-structured-with-a-tiox-seed-layer
#2
Ming Xiao, Kevin P Musselman, Walter W Duley, Y Norman Zhou
The electrical performance of TiO2 nanorod array (NRA) based resistive switching memory devices is examined in this paper. The formation of a seed layer on the fluorine doped tin oxide (FTO) glass substrate after treatment in TiCl4 solution, before the growth of TiO2 NRAs on the FTO substrate via a hydrothermal process, is shown to significantly improve the resistive switching performance of the resulting TiO2 NRA-based device. As fabricated, the Al/TiO2 NRA/TiOx layer/FTO device displayed electroforming-free bipolar resistive switching behavior while maintaining a stable ON/OFF ratio for more than 500 direct sweeping cycles over a retention period of 3×104s...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28096080/fto-genotype-and-weight-loss-systematic-review-and-meta-analysis-of-9563-individual-participant-data-from-eight-randomised-controlled-trials
#3
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28090739/obesity-related-genetic-polymorphisms-and-adiposity-indices-in-a-young-italian-population
#4
Laura Bordoni, Francesca Marchegiani, Marco Piangerelli, Valerio Napolioni, Rosita Gabbianelli
Pediatric obesity develops when a complex biological predisposition collides with an obesogenic environment. To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR). We also tested the combinations of identified risk genotypes and epistatic interactions among them to determine the existence of cumulative effects in predicting the predisposition to gain weight...
January 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28087573/fto-mediated-mrna-demethylation-drives-leukemogenesis
#5
(no author information available yet)
The mRNA demethylase FTO promotes leukemogenesis and inhibits ATRA-mediated differentiation.
January 13, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28067832/type-2-diabetes-susceptibility-in-the-greek-cypriot-population-replication-of-associations-with-tcf7l2-fto-hhex-slc30a8-and-igf2bp2-polymorphisms
#6
Christina Votsi, Costas Toufexis, Kyriaki Michailidou, Athos Antoniades, Nicos Skordis, Minas Karaolis, Constantinos S Pattichis, Kyproula Christodoulou
Type 2 diabetes (T2D) has been the subject of numerous genetic studies in recent years which revealed associations of the disease with a large number of susceptibility loci. We hereby initiate the evaluation of T2D susceptibility loci in the Greek-Cypriot population by performing a replication case-control study. One thousand and eighteen individuals (528 T2D patients, 490 controls) were genotyped at 21 T2D susceptibility loci, using the allelic discrimination method. Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (TCF7L2 rs7901695, FTO rs8050136, HHEX rs5015480, SLC30A8 rs13266634 and IGF2BP2 rs4402960) were observed in this study population...
January 6, 2017: Genes
https://www.readbyqxmd.com/read/28035522/analysis-of-gene-candidate-snp-and-ancestral-origin-associated-to-obesity-and-postoperative-weight-loss-in-a-cohort-of-obese-patients-undergoing-rygb
#7
David Velázquez-Fernández, Gabriela Mercado-Celis, Jeny Flores-Morales, Diana Clavellina-Gaytán, Ramón Vidrio, Eduardo Vidrio, Maureen Mosti, Hugo Sánchez-Aguilar, Donaji Rodriguez, Pablo León, Miguel F Herrera
INTRODUCTION: Obesity is the result of a complex interaction between multiple genetic traits and psychological, behavioral, nutritional and environmental factors. OBJECTIVES: The aims of the study were (a) to comparatively evaluate the presence of 20 candidate gene single nucleotide polymorphisms (SNPs) in morbidly obese patients, (2) their association to comorbid conditions and (3) their impact on weight loss after a Roux-en-Y gastric bypass (RYGB). PATIENTS AND METHODS: Two hundred forty-nine patients were eligible for this study...
December 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28027650/fabrication-of-cufe2o4-%C3%AE-fe2o3-composite-thin-films-on-fto-coated-glass-and-3-d-nanospike-structures-for-efficient-photoelectrochemical-water-splitting
#8
Shabeeb Hussain, Shazia Hussain, Aashir Waleed, Mohammad Mahdi Tavakoli, Zilong Wang, Shihe Yang, Zhiyong Fan, Muhammad Arif Nadeem
Recently, photoelectrochemical conversion (PEC) of water into fuel is attracting great attention of researchers due to its outstanding benefits. Herein, a systematic study on PEC of water using CuFe2O4/ α-Fe2O3 composite thin films is presented. CuFe2O4/ α-Fe2O3 composite thin films were deposited on two different substrates; (1) planner FTO glass and (2) 3-dimensional nanospike (NSP). The films on both substrates were characterized and tested as anode material for photoelectrochemical water splitting reaction...
December 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28027310/m6a-driver-identifying-context-specific-mrna-m6a-methylation-driven-gene-interaction-networks
#9
Song-Yao Zhang, Shao-Wu Zhang, Lian Liu, Jia Meng, Yufei Huang
As the most prevalent mammalian mRNA epigenetic modification, N6-methyladenosine (m6A) has been shown to possess important post-transcriptional regulatory functions. However, the regulatory mechanisms and functional circuits of m6A are still largely elusive. To help unveil the regulatory circuitry mediated by mRNA m6A methylation, we develop here m6A-Driver, an algorithm for predicting m6A-driven genes and associated networks, whose functional interactions are likely to be actively modulated by m6A methylation under a specific condition...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/28026923/inkjet-printing-nio-based-p-type-dye-sensitized-solar-cells
#10
R Brisse, R Faddoul, T Bourgeteau, D Tondelier, J Leroy, S Campidelli, T Berthelot, B Geffroy, B Jousselme
Fabrication at low cost of transparent p-type semiconductors with suitable electronic properties is essential toward the scalability of many electronic devices, especially for photovoltaic and photocatalytic applications. In this context, the synthesis of mesoporous NiO films through inkjet printing of a sol-gel ink was investigated for the first time. Nickel chloride and Pluronic F-127, used as nickel oxide precursor and pore-forming agent, respectively, were formulated in a water/ethanol mixture to prepare a jettable ink for Dimatix printer...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025578/bmi-loci-and-longitudinal-bmi-from-adolescence-to-young-adulthood-in-an-ethnically-diverse-cohort
#11
M Graff, K E North, A S Richardson, K L Young, A L Mazul, H M Highland, K L Mohlke, L A Lange, E M Lange, K M Harris, P Gordon-Larsen
OBJECTIVE: The association of obesity susceptibility variants with change in body mass index (BMI) across the life course is not well understood. SUBJECTS: In ancestry stratified models of 5962 European American (EA), 2080 African American (AA), and 1582 Hispanic American (HA) individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health), we examined associations between 34 obesity SNPs with per year change in BMI, measured by the slope from a growth-curve analysis of two or more BMI measurements between adolescence and young adulthood...
December 27, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28025575/patterned-feeding-induces-neuroendocrine-behavioral-and-genetic-changes-that-promote-palatable-food-intake
#12
S Sirohi, A Van Cleef, J F Davis
BACKGROUND: Selection of a healthy diet is the cornerstone for treating obesity and metabolic disease. Unfortunately, the majority of diets fail leading to weight regain and in some cases, pathological feeding behavior. We hypothesize that alternating bouts of caloric overconsumption and caloric restriction, behavioral manifestations of dieting, induce neuroendocrine, behavioral, and genetic changes that promote future bouts of palatable food intake. METHODS: To test this hypothesis, we subjected male Long Evans rats to a HFD feeding paradigm that induced a pattern of caloric overconsumption and caloric restriction...
December 27, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28019096/zro2-tio2-electron-collection-layer-for-efficient-meso-superstructured-hybrid-perovskite-solar-cells
#13
Mario Alejandro Mejía Escobar, Sandeep Pathak, Jiewei Liu, Henry J Snaith, Franklin Jaramillo
Since the first reports of efficient organic-inorganic perovskite solar cells in 2012, an explosion of research activity has emerged around the world, which has led to a rise in the power conversion efficiencies (PCEs) to over 20%. Despite the impressive efficiency, a key area of the device, which remains sub-optimal is the electronic electron extraction layer and its interface with the photoactive perovskite. Here, we implement an electron collection "bi-layer" composed of a thin layer of zirconia coated with titania, siting upon the transparent conductive oxide fluorine doped tin oxide (FTO)...
December 26, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28017614/fto-plays-an-oncogenic-role-in-acute-myeloid-leukemia-as-a-n-6-methyladenosine-rna-demethylase
#14
Zejuan Li, Hengyou Weng, Rui Su, Xiaocheng Weng, Zhixiang Zuo, Chenying Li, Huilin Huang, Sigrid Nachtergaele, Lei Dong, Chao Hu, Xi Qin, Lichun Tang, Yungui Wang, Gia-Ming Hong, Hao Huang, Xiao Wang, Ping Chen, Sandeep Gurbuxani, Stephen Arnovitz, Yuanyuan Li, Shenglai Li, Jennifer Strong, Mary Beth Neilly, Richard A Larson, Xi Jiang, Pumin Zhang, Jie Jin, Chuan He, Jianjun Chen
N(6)-Methyladenosine (m(6)A) represents the most prevalent internal modification in mammalian mRNAs. Despite its functional importance in various fundamental bioprocesses, the studies of m(6)A in cancer have been limited. Here we show that FTO, as an m(6)A demethylase, plays a critical oncogenic role in acute myeloid leukemia (AML). FTO is highly expressed in AMLs with t(11q23)/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD, and/or NPM1 mutations. FTO enhances leukemic oncogene-mediated cell transformation and leukemogenesis, and inhibits all-trans-retinoic acid (ATRA)-induced AML cell differentiation, through regulating expression of targets such as ASB2 and RARA by reducing m(6)A levels in these mRNA transcripts...
January 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28002401/reversible-methylation-of-m-6-am-in-the-5-cap-controls-mrna-stability
#15
Jan Mauer, Xiaobing Luo, Alexandre Blanjoie, Xinfu Jiao, Anya V Grozhik, Deepak P Patil, Bastian Linder, Brian F Pickering, Jean-Jacques Vasseur, Qiuying Chen, Steven S Gross, Olivier Elemento, Françoise Debart, Megerditch Kiledjian, Samie R Jaffrey
Internal bases in mRNA can be subjected to modifications that influence the fate of mRNA in cells. One of the most prevalent modified bases is found at the 5' end of mRNA, at the first encoded nucleotide adjacent to the 7-methylguanosine cap. Here we show that this nucleotide, N(6),2'-O-dimethyladenosine (m(6)Am), is a reversible modification that influences cellular mRNA fate. Using a transcriptome-wide map of m(6)Am we find that m(6)Am-initiated transcripts are markedly more stable than mRNAs that begin with other nucleotides...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/27995797/a-facile-electrochemical-reduction-method-for-improving-photocatalytic-performance-of-%C3%AE-fe2o3-photoanode-for-solar-water-splitting
#16
Jue Wang, Joseph L Waters, Patrick Kung, Seongsin M Kim, John T Kelly, Louis E McNamara, Nathan I Hammer, Barry C Pemberton, Russell H Schmehl, Arunava Gupta, Shanlin Pan
Electrochemical reduction method is used for the first time to significantly improve the photo-electrochemical performance of α-Fe2O3 photoanode prepared on fluorine-doped tin oxide substrates by spin-coating aqueous solution of Fe(NO3)3 followed by thermal annealing in air. Photocurrent density of α-Fe2O3 thin film photoanode can be enhanced 25 times by partially reducing the oxide film to form more conductive Fe3O4 (magnetite). Fe3O4 helps facilitate efficient charge transport and collection from the top α-Fe2O3 layer upon light absorption and charge separation to yield enhanced photocurrent density...
January 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27994159/genetic-risk-for-obesity-predicts-nucleus-accumbens-size-and-responsivity-to-real-world-food-cues
#17
Kristina M Rapuano, Amanda L Zieselman, William M Kelley, James D Sargent, Todd F Heatherton, Diane Gilbert-Diamond
Obesity is a major public health concern that involves an interaction between genetic susceptibility and exposure to environmental cues (e.g., food marketing); however, the mechanisms that link these factors and contribute to unhealthy eating are unclear. Using a well-known obesity risk polymorphism (FTO rs9939609) in a sample of 78 children (ages 9-12 y), we observed that children at risk for obesity exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27991966/genotypic-carriers-of-the-obesity-associated-fto-polymorphism-exhibit-different-cardiometabolic-profiles-after-an-intervention
#18
Greice G Moraes, Cézane P Reuter, Jane D P Renner, Elisa I Klinger, Michele B Ferreira, Elza D DE Mello, Andréia DE M Valim, Miria S Burgos
Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure...
October 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27989115/bivo4-wo3-sno2-double-heterojunction-photoanode-with-enhanced-charge-separation-and-visible-transparency-for-bias-free-solar-water-splitting-with-a-perovskite-solar-cell
#19
Ji Hyun Baek, Byeong Jo Kim, Gill Sang Han, Sung Won Hwang, Dong Rip Kim, In Sun Cho, Hyun Suk Jung
Coupling dissimilar oxides in heterostructures allows the engineering of interfacial, optical, charge separation/transport and transfer properties of photoanodes for photoelectrochemical (PEC) water splitting. Here, we demonstrate a double-heterojunction concept based on a BiVO4/WO3/SnO2 triple-layer planar heterojunction (TPH) photoanode, which shows simultaneous improvements in the charge transport (∼93% at 1.23 V vs RHE) and transmittance at longer wavelengths (>500 nm). The TPH photoanode was prepared by a facile solution method: a porous SnO2 film was first deposited on a fluorine-doped tin oxide (FTO)/glass substrate followed by WO3 deposition, leading to the formation of a double layer of dense WO3 and a WO3/SnO2 mixture at the bottom...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27974350/genetic-obesity-and-the-risk-of-atrial-fibrillation-causal-estimates-from-mendelian-randomization
#20
Neal A Chatterjee, Franco Giulianini, Bastiaan Geelhoed, Kathryn L Lunetta, Jeffrey R Misialek, Maartje N Niemeijer, Michiel Rienstra, Lynda M Rose, Albert V Smith, Dan E Arking, Patrick T Ellinor, Jan Heeringa, Honghuang Lin, Steven A Lubitz, Elsayed Z Soliman, Niek Verweij, Alvaro Alonso, Emelia J Benjamin, Vilmundur Gudnason, Bruno H Stricker, Pim van der Harst, Daniel I Chasman, Christine M Albert
BACKGROUND: -Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the causal association between BMI and AF using genetic predictors of BMI. METHODS: -We identified 51 646 individuals of European ancestry without AF at baseline from seven prospective population-based cohorts initiated between 1987 and 2002 in the United States, Iceland, and the Netherlands with incident AF ascertained between 1987 and 2012...
December 14, 2016: Circulation
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