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https://www.readbyqxmd.com/read/28636007/analysis-of-association-of-gene-variants-with-obesity-traits-in-new-zealand-european-children-at-6-years-of-age
#1
Mohanraj Krishnan, John M D Thompson, Edwin A Mitchell, Rinki Murphy, Lesley M E McCowan, Andrew N Shelling, G On Behalf Of The Children Of Scope Study Group
Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights into biological factors that contribute to the development of obesity. As obesity tracks through childhood into adulthood, identification of the genetic factors for obesity in early life is important. The objective of this study was to identify putative associations between genetic variants and obesity traits in children at 6 years of age...
June 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28631465/an-interfacial-investigation-on-printable-carbon-based-mesoscopic-perovskite-solar-cells-with-niox-c-back-electrode
#2
Fatemeh Behrouznejad, Cheng-Min Tsai, Sudhakar Narra, Eric W-G Diau, Nima Taghavinia
Solar cells with high-efficiency, low-cost and high-stability are the target for the new generation of solar cells. A fully printable perovskite (CH3NH3PbI3) solar cell (PSC) with device architecture FTO/TiO2/Al2O3/NiOx/C is fabricated in the current research as a low-cost and relatively stable structure and is investigated to determine how different fabrication factors such as the thickness of the insulating spacer layer (Al2O3) or treatments such as heat and UV-O3 treatments can affect the interfacial properties of this multi-layer mesoporous structure...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28626815/part-time-versus-full-time-occlusion-therapy-for-treatment-of-amblyopia-a%C3%A2-meta-analysis
#3
REVIEW
Negareh Yazdani, Ramin Sadeghi, Hamed Momeni-Moghaddam, Leili Zarifmahmoudi, Asieh Ehsaei, Brendan T Barrett
PURPOSE: To compare full-time occlusion (FTO) and part-time occlusion (PTO) therapy in the treatment of amblyopia, with the secondary aim of evaluating the minimum number of hours of part-time patching required for maximal effect from occlusion. METHODS: A literature search was performed in PubMed, Scopus, Science Direct, Ovid, Web of Science and Cochrane library. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28626215/genetic-variation-in-the-obesity-gene-fto-is-not-associated-with-decreased-fat-oxidation-the-neo-study
#4
L L Blauw, R Noordam, S Trompet, J F P Berbée, F R Rosendaal, D van Heemst, K W van Dijk, D O Mook-Kanamori, R de Mutsert, P C N Rensen
BACKGROUND: The FTO gene harbours the strongest common genetic variant associated with obesity. Recently, rs1421085-T to -C substitution mapped in FTO was shown to induce a developmental shift of human adipocytes from an energy-combusting beige to an energy-storing white phenotype in vitro. As browning of adipocytes selectively enhances fat oxidation (FatOx), we hypothesized that rs1421085-C in FTO is associated with deceased FatOx compared with carbohydrate oxidation (CarbOx) and an increased respiratory quotient (RQ)...
June 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28626026/protein-kinase-c%C3%AE-activates-fat-mass-and-obesity-associated-protein-by-influencing-its-ubiquitin-proteasome-degradation
#5
Haoran Tai, Xiaobo Wang, Jiao Zhou, Xiaojuan Han, Tingting Fang, Hui Gong, Ning Huang, Honghan Chen, Jianqiong Qin, Ming Yang, Xiawei Wei, Li Yang, Hengyi Xiao
PKCβ is a serine-threonine kinase associated with obesity and diabetic complications; its activation contributes to weight gain, and deletion of its gene results in resistance to genetic- and diet-induced obesity. Fat mass and obesity-associated (FTO) protein is a recently identified RNA demethylase, and its overexpression in mice leads to increased body weight as well as fat mass. Although sharing some features in anabolism regulation, PKCβ and FTO have not been investigated together; therefore, their relationship has not been established...
June 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28615046/the-association-of-insertions-deletions-indels-and-variable-number-tandem-repeats-vntrs-with-obesity-and-its-related-traits-and-complications
#6
REVIEW
Yee-How Say
BACKGROUND: Despite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity. This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance-collectively known as metabolic syndrome)...
June 14, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28613825/uv-sintered-low-temperature-solution-processed-sno2-as-robust-electron-transport-layer-for-efficient-planar-heterojunction-perovskite-solar-cells
#7
Like Huang, Xiaoxiang Sun, Chang Li, Jie Xu, Rui Xu, Yangyang Du, Jian Ni, Hongkun Cai, Juan Li, Ziyang Hu, Jianjun Zhang
Recently, low-temperature solution-processed tin oxide (SnO2) as versatile electron transport layer (ETL) for efficient and robust planar heterojunction (PH) perovskite solar cells (PSCs) has attracted particular attention due to its outstanding properties such as high optical transparency, high electron mobility, and suitable band alignment. However, for most of the reported works, an annealing temperature of 180 °C is generally required. This temperature can reluctantly said to be a low temperature, especially with respect to the flexible application where 180 °C is still a little too high that PET flexible substrate cannot bear...
June 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28609740/enhanced-photovoltaic-performance-of-dye-sensitized-solar-cells-based-on-nickel-oxide-supported-on-nitrogen-doped-graphene-nanocomposite-as-a-photoanode
#8
Palraj Ranganathan, Ragu Sasikumar, Shen-Ming Chen, Syang-Peng Rwei, Pedaballi Sireesha
We applied the nitrogen-doped graphene@nickel oxide (NGE/NiO) nanocomposite doped TiO2 as a photo-anode for dye-sensitized solar cells (DSSCs) on fluorine-doped tin oxide (FTO) substrates by screen printing method. Power conversion efficiency (PCE) of 9.75% was achieved for this DSSCs device, which is greater than that of DSSCs devices using GO/TiO2, and NiO/TiO2 based photo-anodes (PCE=8.55, and 9.11%). Also, the fill factor (FF) of the DSSCs devices using the NGE/NiO/TiO2 nanocomposite photo-anode was better than that of other photo-anodes...
June 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28607931/genetic-epidemiology-of-type-2-diabetes-in-mexican-mestizos
#9
REVIEW
Eiralí Guadalupe García-Chapa, Evelia Leal-Ugarte, Valeria Peralta-Leal, Jorge Durán-González, Juan Pablo Meza-Espinoza
There are currently about 415 million people with diabetes worldwide, a figure likely to increase to 642 million by 2040. In 2015, Mexico was the second Latin American country and sixth in the world in prevalence of this disorder with nearly 11.5 million of patients. Type 2 diabetes (T2D) is the main kind of diabetes and its etiology is complex with environmental and genetic factors involved. Indeed, polymorphisms in several genes have been associated with this disease worldwide. To estimate the genetic epidemiology of T2D in Mexican mestizos a systematic bibliographic search of published articles through PubMed, Scopus, Google Scholar, and Web of Science was conducted...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28607773/fto-gene-associates-and-interacts-with-obesity-risk-physical-activity-energy-intake-and-time-spent-sitting-pilot-study-in-a-nigerian-population
#10
Bolaji Fatai Oyeyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, Nanfizat Abiket Alamukii
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28607568/review-of-studies-on-the-fat-mass-and-obesity-associated-fto-gene-interactions-with-environmental-factors-affecting-on-obesity-and-its-impact-on-lifestyle-interventions
#11
REVIEW
Naser Kalantari, Saeid Doaei, Nastaran Keshavarz-Mohammadi, Maryam Gholamalizadeh, Naeimeh Pazan
BACKGROUND: The prevalence of obesity is influenced by environmental and genetic factors. Recently, it has been reported that an interaction between genotype and environmental factors can affect each other's effects on the phenotype. The purpose of this study is to evaluate the recent studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and the impact of these interactions on the success level of the lifestyle intervention...
November 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28604899/antireflective-coatings-with-enhanced-adhesion-strength
#12
Sadaf Bashir Khan, Hui Wu, Zhu Fei, Shuai Ning, Zhengjun Zhang
The importance of tuning refractive index in a multilayer antireflection coating (ARC) system can not be denied. In practical applications, regulation of refractive index is complex due to limited choice and availability of appropriate materials for the trilayer AR coating assembly. To overcome this issue, we used a single inorganic material, HfO2, for the construction of a trilayer AR light harvesting moth eye, resembling hierarchical nanostructure coatings, for exploring new generation photovoltaics and optoelectronic devices...
June 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28603074/fto-gene-polymorphisms-rs9939609-and-rs17817449-as-predictors-of-type-2-diabetes-mellitus-in-obese-iraqi-population
#13
Laith A Younus, Abdul Hussein A Algenabi, Mohammed S Abdul-Zhara, Majid K Hussein
BACKGROUND: The variation of the SNPs in FTO (fat mass and obesity associated) gene are improved to be associated with obesity and type 2 diabetes (T2DM) in some ethnic groups for example in European while, this consistency is controversial in Asians and there were few studies in Iraqi population about the effect of this gene on the development of T2DM in obese patients. Therefore, the objective of this study is to investigate the impact of the two common FTO gene variants in the development of T2DM in obese Iraqi patients...
June 8, 2017: Gene
https://www.readbyqxmd.com/read/28599470/the-lipid-metabolism-gene-fto-influences-breast-cancer-cell-energy-metabolism-via-the-pi3k-akt-signaling-pathway
#14
Yazhuo Liu, Ruoyu Wang, Lichuan Zhang, Jianhua Li, Keli Lou, Bingyin Shi
The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA from breast cancer cells and normal breast cells. MDA-MB-231 cells were transfected with miFTO inhibitor or inhibitor control, and cells were assessed for levels of lactic acid, ATP, pyruvate kinase activity, and hexokinase activity assay using specific kits...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28598483/the-photocurrent-response-in-the-perovskite-device-based-on-coordination-polymers-structure-topology-band-gap-and-matched-energy-levels
#15
Hai-Qiang Luo, Xiao-Han Xing, Pan Zhang, Zhi-Shuo Yan, Qing-Feng Zhou, Yun Gong, Jian-Hua Lin
Using a rigid ditopic ligand, 4,5-di(4'-carboxylphenyl)benzene (H2L), three coordination polymers (CPs) formulated as MnL(H2O)2 (1), CdL(H2O) (2) and Mn2L2(DMF)3 (3) have been synthesized and structurally characterized by single-crystal X-ray diffraction. These three CPs display 2D architectures but with different topologies. The experimental data and DFT calculation indicate that CP 2 is a semiconductor, and its CB/VB energy levels match with those of the perovskite CH3NH3PbI3. A FTO/TiO2/CH3NH3PbI3/CP 2 device is fabricated and the CP-based device shows much larger photoresponse under visible light illumination (650 nm > λ > 350 nm, 100 mW cm(-2)) than the individual CP 2...
June 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28597504/gold-core-lead-shell-nanoparticle-loaded-titanium-iv-oxide-prepared-by-underpotential-photodeposition-plasmonic-water-oxidation
#16
Hiroaki Tada, Ryo Negishi, Shin-Ichi Naya, Hisayoshi Kobayashi
Underpotential photodeposition of Pb yields its ultrathin shell layer selectively on the Au(111) surface of Au nanoparticle (NP)-loaded TiO2 (Au/TiO2) with heteroepitaxial nanojunction. The localized surface plasmon resonance of Au/TiO2 undergoes no damping with the Pb-shell formation, and the Pb shell possesses resistance to aerobic oxidation. Mesoporous films comprising of the Au(core)-Pb(shell) NP-loaded TiO2 and unmodified Au/TiO2 were formed on fluorine-doped tin oxide (FTO) electrode. Using them as the photoanode, photoelectrochemical cells were fabricated, and the photocurrent was measured under illumination of simulated sunlight...
June 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28591980/dip-coating-process-engineering-and-performance-optimization-for-three-state-electrochromic-devices
#17
Lu Wu, Dejiang Yang, Lixun Fei, Yue Huang, Fang Wu, Yiling Sun, Jiayuan Shi, Yong Xiang
Titanium dioxide (TiO2) nanoparticles were modified onto fluorine-doped tin oxide (FTO) via dip-coating technique with different nanoparticle sizes, lifting speeds, precursor concentrations, and dipping numbers. Electrodeposition-based electrochromic device with reversible three-state optical transformation (transparent, mirror, and black) was fabricated subsequently by sandwiching a suitable amount of gel electrolyte between modified FTO electrode and flat FTO electrode. Correlation between dip-coating process engineering, morphological features of TiO2 thin films, i...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28591216/modification-effects-of-genetic-polymorphisms-in-fto-il-6-and-hspd1-on-the-associations-of-diabetes-with-breast-cancer-risk-and-survival
#18
Rui-Mei Zhu, Wei Lin, Wei Zhang, Jun-Ting Ren, Yi Su, Jian-Rong He, Ying Lin, Feng-Xi Su, Xiao-Ming Xie, Lu-Ying Tang, Ze-Fang Ren
The contribution of diabetes to breast cancer remains uncertain among Chinese females, which may result from different genetic factors. We evaluated the associations of diabetes, combined with the polymorphisms in the genes of fat mass and obesity-associated gene (FTO), interleukin 6 (IL-6), and heat shock protein 60 (HSPD1), with breast cancer risk and survival in a Chinese Han population. The information on the history of diabetes was collected from 1551 incident breast cancer cases and 1605 age-frequency matched controls in Guangzhou, China...
2017: PloS One
https://www.readbyqxmd.com/read/28585683/the-age-of-developing-diabetes-and-fto-polymorphisms-rs9939609-rs1421085-and-rs9930506
#19
Władysław Grzeszczak, Maciej Molsa, Marek Tłuczykont, Anna Markowicz, Ryszard Swoboda, Marta Biedak, Anna Kałuża, Sebastian Sirek, Krzysztof Strojek
INTRODUCTION: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28577500/a-genosensor-for-detection-of-consensus-dna-sequence-of-dengue-virus-using-zno-pt-pd-nanocomposites
#20
Chaitali Singhal, C S Pundir, Jagriti Narang
An electrochemical genosensor based on Zinc oxide/platinum-palladium (ZnO/Pt-Pd) modified fluorine doped tin oxide (FTO) glass plate was fabricated for detection of consensus DNA sequence of Dengue virus (DENV) using methylene blue (MB) as an intercalating agent. To achieve it, probe DNA (PDNA) was immobilized on the surface of ZnO/Pt-Pd nanocomposites modified FTO electrode. The synthesized nano-composites were characterized by high resolution transmission electron microscopy (HRTEM), energy dispersive X-ray analysis (EDX), atomic force microscopy (AFM), scanning electron microscopy (SEM), UV-Vis spectroscopy, X-ray diffraction (XRD) analysis and Fourier transform infra-red (FTIR) spectroscopy...
May 27, 2017: Biosensors & Bioelectronics
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