keyword
MENU ▼
Read by QxMD icon Read
search

FTO

keyword
https://www.readbyqxmd.com/read/28303696/the-role-of-macronutrient-intake-in-reducing-the-risk-of-obesity-and-overweight-among-carriers-of-different-polymorphisms-of-fto-gene-a-review
#1
Anna Przeliorz-Pyszczek, Bożena Regulska-Ilow
Obesity is a growing problem worldwide. The risk of the excessive body weight occurrence is a multifactorial issue. Environmental factors, lifestyle habits, diet, physical activity level, as well as genetic predisposition can increase obesity risk. One of the genes studied – the FTO gene - plays a crucial role in obesity occurrence. Individuals who carry risk alleles of specific single nucleotide polymorphisms (SNP) have a greater risk of being overweight. Recent studies revealed that specific macronutrient diet composition can influence differently on the FTO expression...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28301549/a-comprehensive-survey-of-genetic-variation-in-20-691-subjects-from-four-large-cohorts
#2
Sara Lindström, Stephanie Loomis, Constance Turman, Hongyan Huang, Jinyan Huang, Hugues Aschard, Andrew T Chan, Hyon Choi, Marilyn Cornelis, Gary Curhan, Immaculata De Vivo, A Heather Eliassen, Charles Fuchs, Michael Gaziano, Susan E Hankinson, Frank Hu, Majken Jensen, Jae H Kang, Christopher Kabrhel, Liming Liang, Louis R Pasquale, Eric Rimm, Meir J Stampfer, Rulla M Tamimi, Shelley S Tworoger, Janey L Wiggs, David J Hunter, Peter Kraft
The Nurses' Health Study (NHS), Nurses' Health Study II (NHSII), Health Professionals Follow Up Study (HPFS) and the Physicians Health Study (PHS) have collected detailed longitudinal data on multiple exposures and traits for approximately 310,000 study participants over the last 35 years. Over 160,000 study participants across the cohorts have donated a DNA sample and to date, 20,691 subjects have been genotyped as part of genome-wide association studies (GWAS) of twelve primary outcomes. However, these studies utilized six different GWAS arrays making it difficult to conduct analyses of secondary phenotypes or share controls across studies...
2017: PloS One
https://www.readbyqxmd.com/read/28297716/rna-m-6-a-methylation-regulates-the-ultraviolet-induced-dna-damage-response
#3
Yang Xiang, Benoit Laurent, Chih-Hung Hsu, Sigrid Nachtergaele, Zhike Lu, Wanqiang Sheng, Chuanyun Xu, Hao Chen, Jian Ouyang, Siqing Wang, Dominic Ling, Pang-Hung Hsu, Lee Zou, Ashwini Jambhekar, Chuan He, Yang Shi
Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA damage present intracellularly and in the external environment. A system of DNA repair, called the DNA damage response, detects and repairs damaged DNA and prevents cell division until the repair is complete. Here we report that methylation at the 6 position of adenosine (m(6)A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation...
March 15, 2017: Nature
https://www.readbyqxmd.com/read/28297667/m-6-a-rna-methylation-regulates-the-self-renewal-and-tumorigenesis-of-glioblastoma-stem-cells
#4
Qi Cui, Hailing Shi, Peng Ye, Li Li, Qiuhao Qu, Guoqiang Sun, Guihua Sun, Zhike Lu, Yue Huang, Cai-Guang Yang, Arthur D Riggs, Chuan He, Yanhong Shi
RNA modifications play critical roles in important biological processes. However, the functions of N(6)-methyladenosine (m(6)A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. Here, we show that m(6)A mRNA modification is critical for glioblastoma stem cell (GSC) self-renewal and tumorigenesis. Knockdown of METTL3 or METTL14, key components of the RNA methyltransferase complex, dramatically promotes human GSC growth, self-renewal, and tumorigenesis. In contrast, overexpression of METTL3 or inhibition of the RNA demethylase FTO suppresses GSC growth and self-renewal...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28294566/artificial-photosynthesis-of-alcohols-via-multi-functionalized-semiconductor-photocathodes
#5
Yuqian Zhang, Bo Han, Yanjie Xu, Dongning Zhao, Yongjian Jia, Rong Nie, Zhouhe Zhu, Fengjuan Chen, Jianguo Wang, Huanwang Jing
Novel artificial photosynthesis systems are devised as cells of dye/Pd/NR-MOx (M = Ti, Zn)||Co-Pi/W:BiVO4 that convert efficiently CO2 to alcohols. The photocathodes are amino-functionalized, palladium deposited and in-situ sensitized nano-TiO2 or ZnO/FTO electrodes that are characterized by XPS, TEM, XRD, UV-vis spectra and determined by electrochemical techniques. The cell of dye/Pd/S-TiO2||Co-Pi/W:BiVO4 uniquely generates ethanol under irradiation of 200 mW/cm2, reaching 0.56 % light quantum efficiency (QE) at 0...
March 15, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28294082/genetics-of-fat-intake-in-the-determination-of-body-mass
#6
Agata Chmurzynska, Monika A Mlodzik
Body mass and fat intake are multifactorial traits that have genetic and environmental components. The gene with the greatest effect on body mass is FTO (fat mass and obesity-associated), but several studies have shown that the effect of FTO (and of other genes) on body mass can be modified by the intake of nutrients. The so-called gene-environment interactions may also be important for the effectiveness of weight-loss strategies. Food choices, and thus fat intake, depend to some extent on individual preferences...
March 15, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28288181/nucleocytoplasmic-shuttling-of-fto-does-not-affect-starvation-induced-autophagy
#7
Aleksander Aas, Pauline Isakson, Christian Bindesbøll, Endalkachew A Alemu, Arne Klungland, Anne Simonsen
Polymorphic variants of the FTO (fat mass and obesity) gene associate with body mass index in humans, but the underlying molecular mechanisms have not been firmly determined. FTO is linked to energy homeostasis via amino acid sensing and is thought to activate the mammalian target of rapamycin complex 1, a negative regulator of autophagy. FTO localises both to the nucleus and the cytoplasm, and in this study we identify a functional nuclear localisation signal (NLS) in the N-terminus of FTO, as well as nuclear localization information in its very C-terminus...
2017: PloS One
https://www.readbyqxmd.com/read/28286582/effects-of-the-functionalization-of-the-ordered-mesoporous-carbon-support-surface-on-iron-catalysts-for-the-fischer-tropsch-synthesis-of-lower-olefins
#8
Martin Oschatz, Jan P Hofmann, Tom W van Deelen, Wouter S Lamme, Nynke A Krans, Emiel J M Hensen, Krijn P de Jong
Ordered mesoporous carbon (CMK-3) with different surface modifications is applied as a support for Fe-based catalysts in the Fischer-Tropsch to olefins synthesis (FTO) with and without sodium and sulfur promoters. Different concentrations of functional groups do not affect the size (3-5 nm) of Fe particles in the fresh catalysts but iron (carbide) supported on N-enriched CMK-3 and a support with a lower concentration of functional groups show higher catalytic activity under industrially relevant FTO conditions (340 °C, 10 bar, H2/CO=2) compared to a support with an O-enriched surface...
February 21, 2017: ChemCatChem
https://www.readbyqxmd.com/read/28282466/fat-mass-and-obesity-associated-gene-fto-is-associated-to-eating-disorders-susceptibility-and-moderates-the-expression-of-psychopathological-traits
#9
Giovanni Castellini, Marica Franzago, Silvia Bagnoli, Lorenzo Lelli, Michela Balsamo, Milena Mancini, Benedetta Nacmias, Valdo Ricca, Sandro Sorbi, Ivana Antonucci, Liborio Stuppia, Giovanni Stanghellini
Eating Disorders (EDs) show a multifactorial etiopathogenesis including environmental, psychological and biological factors. In the present study, we propose a model of interactions between genetic vulnerability-represented by Fat Mass and Obesity-Associated (FTO) gene-and stable psychopathological traits, such as bodily disorders and emotion dysregulation for EDs patients. The distribution of a polymorphism of the FTO (rs9939609 T>A) was evaluated in a series of 250 EDs patients and in a group of 119 healthy control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28281539/extensive-translation-of-circular-rnas-driven-by-n-6-methyladenosine
#10
Yun Yang, Xiaojuan Fan, Miaowei Mao, Xiaowei Song, Ping Wu, Yang Zhang, Yongfeng Jin, Yi Yang, Lingling Chen, Yang Wang, Catherine Cl Wong, Xinshu Xiao, Zefeng Wang
Extensive pre-mRNA back-splicing generates numerous circular RNAs (circRNAs) in human transcriptome. However, the biological functions of these circRNAs remain largely unclear. Here we report that N(6)-methyladenosine (m(6)A), the most abundant base modification of RNA, promotes efficient initiation of protein translation from circRNAs in human cells. We discover that consensus m(6)A motifs are enriched in circRNAs and a single m(6)A site is sufficient to drive translation initiation. This m(6)A-driven translation requires initiation factor eIF4G2 and m(6)A reader YTHDF3, and is enhanced by methyltransferase METTL3/14, inhibited by demethylase FTO, and upregulated upon heat shock...
March 10, 2017: Cell Research
https://www.readbyqxmd.com/read/28275132/impact-of-polyunsaturated-and-saturated-fat-overfeeding-on-the-dna-methylation-pattern-in-human-adipose-tissue-a-randomized-controlled-trial
#11
Alexander Perfilyev, Ingrid Dahlman, Linn Gillberg, Fredrik Rosqvist, David Iggman, Petr Volkov, Emma Nilsson, Ulf Risérus, Charlotte Ling
Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) have different metabolic responses.Objective: We investigated whether the epigenome of human adipose tissue is affected differently by dietary fat composition and general overfeeding in a randomized trial.Design: We studied the effects of 7 wk of excessive SFA (n = 17) or PUFA (n = 14) intake (+750 kcal/d) on the DNA methylation of ∼450,000 sites in human subcutaneous adipose tissue...
March 8, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28267420/fto-promotes-adipogenesis-through-inhibition-of-the-wnt-%C3%AE-catenin-signaling-pathway-in-porcine-intramuscular-preadipocytes
#12
Xiaoling Chen, Yanliu Luo, Gang Jia, Guangmang Liu, Hua Zhao, Zhiqing Huang
Numerous studies have demonstrated that FTO plays an important role in adipogenesis. Herein, we designed a small interfering RNA targeting FTO to knock down its endogenous expression and investigated its effects on the proliferation and differentiation of porcine intramuscular preadipocytes. Its possible mechanism was also investigated. We showed that FTO silencing significantly decreased the level of phospho-Histone H3 protein and inhibited the proliferation of porcine intramuscular preadipocytes. In addition, the expressions of peroxisome proliferators-activated receptor γ (PPARγ) and CAAT/enhancer binding protein (C/EBPα) were down-regulated, but the expression of β-catenin was up-regulated, by FTO silencing...
March 7, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28264164/the-physical-mechanism-behind-enhanced-photoelectrochemical-photocatalytic-properties-of-superhydrophilic-assemblies-of-3d-tio2-microspheres-with-arrays-of-oriented-single-crystalline-tio2-nanowires-as-building-blocks-deposited-on-fto
#13
Subha Sadhu, Preeti Gupta, Pankaj Poddar
In comparison to the one dimensional (1D) semiconductor nanostructures, the hierarchical, three-dimensional (3D) microstructures, composed of the arrays of 1D nanostructures as the building blocks, show quite unique physicochemical properties due to efficient photon capture, enhanced surface to volume ratio, which aid to improve the performance of various optoelectronic devices. In this contribution, we report the fabrication of surfactant-free, radially-assembled, 3D titania (rutile phase) microsphere arrays (3D-TMSAs) composed of bundles of single-crystalline titania nanowires (NWs) directly on fluorine-dope conducting oxide (FTO) substrates with tunable architecture...
March 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28257836/association-analysis-of-fto-gene-polymorphisms-with-obesity-in-greek-adults
#14
Yiannis Goutzelas, Kalliopi Kotsa, Yiannis Vasilopoulos, Xanthippi Tsekmekidou, Costas Stamatis, John G Yovos, Theologia Sarafidou, Zissis Mamuris
Nowadays, obesity is the greatest scourge worldwide, particularly for the developed countries and is a huge burden for the public health. Over the past decade, GWAS have revealed a number of genes associated with obesity. The fat mass and obesity associated (FTO) gene was the first one associated with obesity in a significant number of populations and recent meta-analysis studies confirm this association. FTO is a N-methyladenosine demethylase and in addition to the genetic association, its biological role in the regulation of body weight has been documented...
February 28, 2017: Gene
https://www.readbyqxmd.com/read/28254046/photoelectrochemical-performance-of-birnessite-films-and-photoelectrocatalytic-activity-toward-oxidation-of-phenol
#15
Huiqin Zhang, Hongrui Ding, Xin Wang, Cuiping Zeng, Anhuai Lu, Yan Li, Changqiu Wang
Birnessite films on fluorine-doped tin oxide (FTO) coated glass were prepared by cathodic reduction of aqueous KMnO4. The deposited birnessite films were characterized with X-ray diffraction, Raman spectroscopy, scanning electron microscopy and atomic force microscopy. The photoelectrochemical activity of birnessite films was investigated and a remarkable photocurrent in response to visible light was observed in the presence of phenol, resulting from localized manganese d-d transitions. Based on this result, the photoelectrocatalytic oxidation of phenol was investigated...
February 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28253220/fat-mass-and-obesity-associated-protein-attenuates-lipid-accumulation-in-macrophage-foam-cells-and-alleviates-atherosclerosis-in-apolipoprotein-e-deficient-mice
#16
Chunfen Mo, Ming Yang, Xiaojuan Han, Junhong Li, Guangping Gao, Haoran Tai, Ning Huang, Hengyi Xiao
OBJECTIVE: Genome-wide association studies have linked variants of fat mass and obesity-associated protein (FTO) to obesity. However, the molecular function of FTO remains unclear. In this study, we sought to investigate the potential effects of FTO in modulating cholesterol deposition in macrophage foam cells, as well as whether FTO exerts antiatherosclerotic properties in apolipoprotein E-deficient mice. METHOD AND RESULTS: We transfected RAW264.7 cells with plasmids encoding a wild-type or mutant FTO gene (I367F)...
April 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28240557/all-in-one-derivatized-tandem-p-n-silicon-sno2-tio2-water-splitting-photoelectrochemical-cell
#17
Matthew V Sheridan, David J Hill, Benjamin D Sherman, Degao Wang, Seth L Marquard, Kyung-Ryang Wee, James F Cahoon, Thomas J Meyer
Mesoporous metal oxide film electrodes consisting of derivatized 5.5 μm thick SnO2 films with an outer 4.3 nm shell of TiO2 added by atomic layer deposition (ALD) have been investigated to explore unbiased water splitting on p, n, and p(+)n type silicon substrates. Modified electrodes were derivatized by addition of the water oxidation catalyst, [Ru(bda)(4-O(CH2)3PO3H2)-pyr)2], 1, (pyr = pyridine; bda = 2,2'-bipyridine-6,6'-dicarboxylate), and chromophore, [Ru(4,4'-PO3H2-bpy) (bpy)2](2+), RuP(2+), (bpy = 2,2'-bipyridine), which form 2:1 RuP(2+)/1 assemblies on the surface...
March 3, 2017: Nano Letters
https://www.readbyqxmd.com/read/28220970/in-situ-growth-of-120-cm-2-ch3-nh3-pbbr3-perovskite-crystal-film-on-fto-glass-for-narrowband-photodetectors
#18
Hua-Shang Rao, Wen-Guang Li, Bai-Xue Chen, Dai-Bin Kuang, Cheng-Yong Su
Organometal trihalide perovskites have been attracting intense attention due to their enthralling optoelectric characteristics. Thus far, most applications focus on polycrystalline perovskite, which however, is overshadowed by single crystal perovskite with superior properties such as low trap density, high mobility, and long carrier diffusion length. In spite of the inherent advantages and significant optoelectronic applications in solar cells and photodetectors, the fabrication of large-area laminar perovskite single crystals is challenging...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28211337/enhanced-electrochemical-degradation-of-ibuprofen-in-aqueous-solution-by-ptru-alloy-catalyst
#19
Chiung-Fen Chang, Tsan-Yao Chen, Ching-Ju Monica Chin, Yu-Tsun Kuo
Electrochemical advanced oxidation processes (EAOPs) regarded as a green technology for aqueous ibuprofen treatment was investigated in this study. Multi-walled carbon nanotubes (MWCNTs), Pt nanoparticles (Pt NPs), and PtRu alloy, of which physicochemical properties were characterized by XRD and X-ray absorption spectroscopy, were used to synthesize three types of cheap and effective anodes based on commercial conductive glass. Furthermore, the operating parameters, such as the current densities, initial concentrations, and solution pH were also investigated...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28211274/large-grain-based-hole-blocking-layer-free-planar-type-perovskite-solar-cell-with-best-efficiency-of-18-20
#20
Haejun Yu, Jaehoon Ryu, Jong Woo Lee, Jongmin Roh, Kisu Lee, Juyoung Yun, Jungsup Lee, Yun Ki Kim, Doyk Hwang, Jooyoun Kang, Seong Keun Kim, Jyongsik Jang
There remains tremendous interest in perovskite solar cells (PSCs) in the solar energy field; the certified power conversion efficiency (PCE) now exceeds 20%. Along with research focused on enhancing PCE, studies are also underway concerning PSC commercialization. It is crucial to simplify the fabrication process and reduce the production cost to facilitate commercialization. Herein, we successfully fabricated highly efficient hole-blocking layer (HBL)-free PSCs through vigorously interrupting penetration of hole-transport material (HTM) into fluorine-doped tin oxide by a large grain based-CH3NH3PbI3 (MAPbI3) film, thereby obtaining a PCE of 18...
February 23, 2017: ACS Applied Materials & Interfaces
keyword
keyword
44604
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"