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Yandong Jiang, Dali Liu, Yudan Yang, Ru Xu, Tianxiang Zhang, Kuang Sheng, Hongwei Song
In this work, a new photoelectrochemical biosensor based on Ag2S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag2S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag2S expanded the scope of light absorption to long wavelength, which can make full use of the light energy...
December 6, 2016: Scientific Reports
Iwona Rotter, Karolina Skonieczna-Żydecka, Danuta Kosik-Bogacka, Grażyna Adler, Aleksandra Rył, Maria Laszczyńska
PURPOSE: Metabolic disorders, including MetS, obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well as sex hormone concentrations. SUBJECTS AND METHODS: This study involved 272 men of Caucasian descent aged 50-75 years...
2016: Clinical Interventions in Aging
Tooru M Mizuno, Pei San Lew, Yanming Luo, Arnold Leckstrom
AIMS: To investigate the role of glucose and insulin in the regulation of hepatic fat mass and obesity associated (Fto) gene expression and the role of hepatic Fto in the regulation of gluconeogenic gene expression. MAIN METHODS: To determine the effect of hyperglycemia on hepatic Fto expression, levels of Fto mRNA in liver were compared between normoglycemic/normoinsulinemic, hypereglycemic/hyperinsulinemic, and hyperglycemic/hypoinsulinemic mice. To determine the direct effect of insulin on Fto expression, levels of Fto, glucose-6-phosphatase (G6pase), and phosphoenolpyruvate carboxykinase (Pepck) mRNA levels were compared between control and insulin-treated mouse liver tissues cultured ex vivo and immortalized mouse hepatocytes AML12...
November 30, 2016: Life Sciences
Kimberly Goodyear, Mary R Lee, Melanie L Schwandt, Colin A Hodgkinson, Lorenzo Leggio
OBJECTIVES: Alcohol dependence represents a leading cause of mortality and morbidity. Understanding the variables that contribute to this diagnosis and its severity is critical. An overlap between factors that may predispose people to become obese and those that may increase the risk of alcohol dependence may exist. However, data in the literature are not conclusive. Therefore, this study aimed to identify the association between alcohol dependence and obesity-related factors, including biochemical and genetic factors...
December 1, 2016: World Journal of Biological Psychiatry
Gihoon Cha, Marco Altomare, Nhat Truong Nguyen, Nicola Taccardi, Kiyoung Lee, Patrik Schmuki
Self-standing TiO2 nanotube layers in the form of membranes are fabricated by self-organizing anodization of Ti metal and a potential shock technique. The membranes were then decorated by sputtering different Pt amounts i) only at the top, ii) only at the bottom or iii) at both top and bottom of the tube layers. The Pt-decorated membranes are transferred either in tube top up or in tube top down configuration onto FTO slides and investigated after crystallization as photocatalysts for H2 generation using either front or back-side light irradiation...
November 29, 2016: Chemistry, An Asian Journal
Tsung-Yan Tsai, Po-Ruei Yan, Sheng-Hsiung Yang
The goal of this research is to prepare inverted light-emitting devices with improved performance by combining titanium dioxide (TiO2) nanorods and tungsten trioxide (WO3) layer. TiO2 nanorods with different lengths were established directly on the fluorine-doped tin oxide (FTO) substrates by the hydrothermal method. The prepared TiO2 nanorods with lengths shorter than 200 nm possess transmittance higher than 80% in the visible range. Inverted light-emitting devices with the configuration of FTO/TiO2 nanorods/ionic PF/MEH-PPV/PEDOT:PSS/WO3/Au were constructed...
December 2016: Nanoscale Research Letters
Erik A Ehli, Abdel Abdellaoui, Iryna O Fedko, Charlie Grieser, Sahar Nohzadeh-Malakshah, Gonneke Willemsen, Eco Jc de Geus, Dorret I Boomsma, Gareth E Davies, Jouke J Hottenga
As an example of optimizing population-specific genotyping assays using a whole-genome sequence reference set, we detail the approach that followed to design the Axiom-NL array which is characterized by an improved imputation backbone based on the Genome of the Netherlands (GoNL) reference sequence and, compared with earlier arrays, a more comprehensive inclusion of SNPs on chromosomes X, Y, and the mitochondria. Common variants on the array were selected to be compatible with the Illumina Psych Array and the Affymetrix UK Biobank Axiom array...
November 23, 2016: European Journal of Human Genetics: EJHG
Hyungkyu Han, Francesca Riboni, Frantisek Karlicky, Stepan Kment, Anandarup Goswami, Pitchaimuthu Sudhagar, Jeongeun Yoo, Lei Wang, Ondrej Tomanec, Martin Petr, Ondrej Haderka, Chiaki Terashima, Akira Fujishima, Patrik Schmuki, Radek Zboril
We report the fabrication of 3D hierarchical hetero-nanostructures composed of thin α-Fe2O3 nanoflakes branched on TiO2 nanotubes. The novel α-Fe2O3/TiO2 hierarchical nanostructures, synthesized on FTO through a multi-step hydrothermal process, exhibit enhanced performances in photo-electrochemical water splitting and in the photocatalytic degradation of an organic dye, with respect to pure TiO2 nanotubes. An enhanced separation of photogenerated charge carriers is here proposed as the main factor for the observed photo-activities: electrons photogenerated in TiO2 are efficiently collected at FTO, while holes are transferred to the α-Fe2O3 nanobranches that serve as charge mediators to the electrolyte...
November 22, 2016: Nanoscale
Chuan-Sen Yang, Da-Shan Shang, Yi-Sheng Chai, Li-Qin Yan, Bao-Gen Shen, Young Sun
Solid state electrochemical cells with synaptic functions have important applications in building smart-terminal networks. Here, the essential synaptic functions including potentiation and depression of synaptic weight, transition from short- to long-term plasticity, spike-rate-dependent plasticity, and spike-timing-dependent plasticity behavior were successfully realized in an Ag/MoOx/fluorine-doped tin oxide (FTO) cell with continual resistance switching. The synaptic plasticity underlying these functions was controlled by tuning the excitatory post-synaptic current (EPSC) decay, which is determined by the applied voltage pulse number, width, frequency, and intervals between the pre- and post-spikes...
November 17, 2016: Physical Chemistry Chemical Physics: PCCP
Ali Eatemadi, Hadis Daraee, Hammed T Aiyelabegan, Babak Negahdari, Bahram Rajeian, Nosratollah Zarghami
BACKGROUND: Nano-therapy exhibit the potential of revolutionizing cancer therapy. This field introduces nanovectors/nanocarriers for anticancer drugs targeted delivery, and also finds application in imaging. Chrysin, a natural flavonoid, was recently studied as having important biological roles in chemical defenses, nitrogen fixation, anti-inflammatory, and anti-oxidant properties. We aim at studying the effect of nano-chrysin on breast cancer cell line. METHODS: The effect of chrysin loaded PCL-PEG-PCL was studied on T47D breast cancer cell line...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Theresia M Schnurr, Anette P Gjesing, Camilla H Sandholt, Anna Jonsson, Yuvaraj Mahendran, Christian T Have, Claus T Ekstrøm, Anne-Louise Bjerregaard, Soren Brage, Daniel R Witte, Marit E Jørgensen, Mette Aadahl, Betina H Thuesen, Allan Linneberg, Hans Eiberg, Oluf Pedersen, Niels Grarup, Tuomas O Kilpeläinen, Torben Hansen
OBJECTIVES: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF...
2016: PloS One
Ben A Johnson, Asamanjoy Bhunia, Sascha Ott
A molecular water oxidation catalyst, [Ru(tpy)(dcbpy)(OH2)](ClO4)2 (tpy = 2,2':6',2''-terpyridine, dcbpy = 2,2'-bipyridine-5,5'-dicarboxylic acid) [1], has been incorporated into FTO-grown thin films of UiO-67 (UiO = University of Oslo), by post-synthetic ligand exchange. Cyclic voltammograms (0.1 M borate buffer at pH = 8.4) of the resulting UiO67-[RuOH2]@FTO show a reversible wave associated with the Ru(III/II) couple in the anodic scan, followed by a large current response that arises from electrocatalytic water oxidation beyond 1...
November 15, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Xin Gao, Xiangxuan Liu, Xuanjun Wang, Zuoming Zhu, Zheng Xie, Jun Li
Photocatalysis technology could utilize solar energy to degrade many toxic pollutants and provides possibility to deal with unsymmetrical dimethylhydrazine (UDMH) wastewater with less energy consumption. In this study, well-aligned TiO2 nanorod arrays (TiO2 NRAs) were grown directly on transparent conductive glass (FTO) via a hydrothermal method, and TiO2 NRAs/CdS heterostructure films were prepared by decorating TiO2 NRAs with CdS nanoparticles through successive ion layer adsorption and reaction (SILAR). Under visible light, the TiO2 NRAs/CdS heterostructure displays enhanced photodegrading capacity compared with the bare TiO2 NRAs, and the highest photodegradation rate, 27...
December 2016: Nanoscale Research Letters
Pablo García-Solís, Marissa Reyes-Bastidas, Karla Flores, Olga P García, Jorge L Rosado, Lorena Méndez-Villa, Carlota Garcia-G, David García-Gutiérrez, Aarón Kuri-García, Hebert L Hernández-Montiel, Ofelia Soriano-Leon, Maria Elena Villagrán-Herrera, Juan C Solis-Sainz
Childhood overweight and obesity are worldwide public health problems and risk factors for chronic diseases. The presence of SNP in several genes has been associated with the presence of obesity. A total of 580 children (8-13 years old) from Queretaro, Mexico, participated in this cross-sectional study, which evaluated the associations of rs9939609 (fat mass obesity-associated (FTO)), rs17782313 (melanocortin 4 receptor (MC4R)) and rs6548238 (transmembrane protein 18 (TMEM18)) SNP with obesity and metabolic risk factors...
November 10, 2016: British Journal of Nutrition
Justiina Ronkainen, Eleonora Mondini, Francesca Cinti, Saverio Cinti, Sylvain Sebért, Markku J Savolainen, Tuire Salonurmi
Genetic variants in the fat mass- and obesity-associated gene Fto are linked to the onset of obesity in humans. The causal role of the FTO protein in obesity is supported by evidence obtained from transgenic mice; however, the underlying molecular pathways pertaining to the role of FTO in obesity have yet to be established. In this study, we investigate the Fto gene in mouse brown adipose tissue and in the browning process of white adipose tissue. We analyze distinct structural and molecular factors in brown and white fat depots of Fto-deficient mice under normal and obesogenic conditions...
November 7, 2016: International Journal of Molecular Sciences
Yutaka Kamura, Minoru Iwata, Shiro Maeda, Satomi Shinmura, Yukiko Koshimizu, Hisae Honoki, Kazuhito Fukuda, Manabu Ishiki, Isao Usui, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuyuki Tobe
AIM: Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass increases remains controversial. To investigate this issue, we examined the association of FTO variants with T2D and various aspects of BMI history during adult life in a Japanese population. METHODS: We genotyped SNPs within FTO (rs1121980 and rs1558902) in 760 Japanese patients with T2D who had reached a lifetime maximum BMI (BMImax) before or at the time of diagnosis and 693 control individuals with information regarding their BMImax...
2016: PloS One
Yanhu Wang, Shenguang Ge, Lina Zhang, Jinghua Yu, Mei Yan, Jiadong Huang
In this study, based on in situ generation of CdS quantum dots (QDs) on the surface of branched TiO2 (B-TiO2) nanorods, an solar innovative photoelectrochemical (PEC) sensing platform was constructed for real-time, and sensitive detection of cellular H2S. Specifically, B-TiO2 nanorods arrays consisting of TiO2 nanorods directly grown on fluorine-doped tin oxide (FTO) further using TiCl3 mediated surface treatment of TiO2 nanorods are designed and fabricated as a new type of photoelectrode. CdS quantum dots (QDs) was formed on the surface of B-TiO2 nanorods arrays through the reaction between Cd(2+) and S(2-)...
September 29, 2016: Biosensors & Bioelectronics
Lijiao Zhang, Ting Ren, Xianhai Tian, Zechun Wang, Wenquan Yu, Ruiyong Wang, Junbiao Chang
In this paper, The binding of twelve 1,3-diazaheterocyclic compounds (1a-1 l) to the fat mass and obesity-associated (FTO) protein was investigated by fluorescence, UV-vis absorption spectroscopy and molecular modeling. Results indicated that the intrinsic fluorescence of FTO is quenched by the nine compounds (1a-1i) with a static quenching procedure. No interaction was observed between FTO protein and compounds (1j-1 l). The thermodynamic parameters obtained from the fluorescence data showed that the hydrophobic force played a major role in stabilizing the complex...
November 4, 2016: Journal of Fluorescence
Eunice Y Chen, Thomas M Olino, Chris J Conklin, Feroze B Mohamed, W Scott Hoge, Gary D Foster, Jean M Arlt, Kalina Eneva, Judy R Kidd, Kenneth R Kidd, Michelle R Lent, Susan Murray, Andrew Newberg, Colleen Tewksbury, Stephanie S VanderVeur, Angelina Yiu
OBJECTIVE: To examine neural mechanisms of action in behavioral weight loss treatment (BWL) and explore neural and genetic predictors of BWL. METHODS: Neural activation to milkshake receipt and genetics were compared in 17 women with obesity who received 12 weeks of BWL and 17 women who received no intervention. Participants were scanned twice using functional magnetic resonance imaging at baseline and 12 weeks. Weight was assessed at baseline, 12, 36, and 60 weeks...
November 2, 2016: Obesity
Abdalaziz Aljabour, Dogukan Hazar Apaydin, Halime Coskun, Faruk Ozel, Mustafa Ersoz, Philipp Stadler, Niyazi Serdar Sariciftci, Mahmut Kus
The current study reports the application of chalcopyrite semiconductor CuInS2 (CIS) nanofibers for the reduction of CO2 to CO with a remarkable faradaic efficiency of 70-80%. Initially the synthesis of CuInS2 nanofibers was carried by adaptable electrospinning technique. In order to reduce the imperfection in the crystalline fiber Polyacrylonitrile (PAN) was selected as template polymer. Afterwards the desired chemical structure of nanofibers was achieved through sulfurization process. Making continuous CuInS2 nanofibers on the cathode surface by electrospinning method brings the advantages of being economical, environmentally safe and versatile...
November 1, 2016: ACS Applied Materials & Interfaces
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