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Sasha R Howard, Leonardo Guasti, Ariel Poliandri, Alessia David, Claudia P Cabrera, Michael R Barnes, Karoliina Wehkalampi, Stephen O'Rahilly, Catherine E Aiken, Anthony P Coll, Marcella Ma, Debra Rimmington, Giles S H Yeo, Leo Dunkel
Context: Self-limited delayed puberty (DP) is often associated with delay in physical maturation, but whilst highly heritable the causal genetic factors remain elusive. Genome-wide association studies of the timing of puberty have identified multiple loci for age of menarche (AAM) in females and voice break in males, particularly in pathways controlling energy balance. Objective/Main outcome measures: We aimed to assess the contribution of rare variants in such genes to the phenotype of familial DP...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
Xinjian Feng, Ke Li, Xia Sheng, Liping Chen, Tao Xu, Kai Zhu, Jie Liu
Mesoporous semiconductor films are of considerable interest for applications in photoelectrochemical devices, however, despite intensive research till now, their charge transport properties remain significantly lower than their single-crystal counterparts. Herein, we report a novel low-temperature template-free technique for growing high surface area mesoporous anatase TiO2 films with a preferred [001] crystalline-orientation on FTO-coated glass substrate. Compared to mesoporous films that comprised of randomly oriented crystallites, the uniaxial orientation enables a 100-fold increase in the rate of electron transport...
November 21, 2017: Chemistry: a European Journal
Jaroslav A Hubacek, Dana Dlouha, Marta Klementova, Vera Lanska, Tomas Neskudla, Terezie Pelikanova
BACKGROUND: Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications. METHODS: Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2339 individuals) - both of Czech origin - were genotyped for the FTO rs17817449 SNP...
November 14, 2017: Gene
Yuan Gao, Yuanjing Lin, Zehua Peng, Qingfeng Zhou, Zhiyong Fan
Herein, a unique three-dimensionally interconnected nanoporous structure (3-D INPOS) pseudocapacitor electrode, which possesses a large surface area, an efficient electron and ion transport, together with a remarkable structural stability, has been constructed via soft anodization of an aluminum alloy, cost-effective ultrasonic spray pyrolysis (USP)-assisted deposition of fluorine-doped tin oxide (FTO), and controllable electrochemical deposition of nanostructured manganese dioxide (MnO2). Taking the advantage of large surface area, the as-built 3-D INPOS pseudocapacitor electrode exhibits the highest areal capacitance of 540 mF cm(-2) and a volumetric capacitance of 135 F cm(-3), which is 53% higher than that achieved from the conventional 3-D nanopore pseudocapacitor electrode and 17...
November 16, 2017: Nanoscale
Dong Han, Cuncun Wu, Yunbiao Zhao, Yi Chen, Lixin Xiao, Ziqiang Zhao
In recent years, perovskite solar cells have drawn widespread attention. As an electrode material, fluorine-doped tin oxide (FTO) is widely used in various kinds of solar cells. However, the relatively low work function (WF) (~4.6 eV) limits its application. The potential barrier between the transparent conductive oxide (TCO) electrode and the hole transport layer (HTL) in inverted perovskite solar cells results in device performance decrease. In this paper, we propose a method to adjust WF of FTO by implanting zirconium ions into the FTO surface...
November 15, 2017: ACS Applied Materials & Interfaces
Róbert Wagner, Ádám G Tabák, Ellen Fehlert, Louise Fritsche, Benjamin A Jaghutriz, Róbert J Bánhegyi, Sebastian M Schmid, Harald Staiger, Fausto Machicao, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Martin Heni
Variation in FTO is the most important common genetic determinant of body weight. Altered energy metabolism could underlie this association. We hypothesized that higher circulating glucose or triglycerides can amplify the FTO impact on BMI. In 2671 subjects of the TUEF study, we investigated the interaction effect of fasting glucose and triglyceride levels with rs9939609 in FTO on BMI. We analysed the same interaction effect by longitudinally utilizing mixed effect models in the prospective Whitehall II study...
November 14, 2017: Scientific Reports
Dilip K Yadav, Smeeta Shrestha, Karen A Lillycrop, Charu V Joglekar, Hong Pan, Joanna D Holbrook, Caroline Hd Fall, Chittaranjan S Yajnik, Giriraj R Chandak
AIM: To investigate the effect of B12 and/or folic acid supplementation on genome-wide DNA methylation. METHODS: We performed Infinium HumanMethylation450 BeadChip (Zymo Research, CA, USA) assay in children supplemented with B12 and/or folic acid (n = 12 in each group) and investigated the functional mechanism of selected differentially methylated loci. RESULTS: We noted significant methylation changes postsupplementation in B12 (589 differentially methylated CpGs and 2892 regions) and B12 + folic acid (169 differentially methylated CpGs and 3241 regions) groups...
November 14, 2017: Epigenomics
Zhigang Li, Zechun Wang, Ning Wang, Xinxin Han, Wenquan Yu, Ruiyong Wang, Junbiao Chang
In this work, the interactions between fat mass and obesity-associated (FTO) protein and three fluoronucleoside analogues (three-member-ring compound (1a), five-member-ring compound (1b) and six-member-ring compound (1c)) have been investigated by fluorescence, ultraviolet-visible absorption spectroscopy, isothermal titration calorimetric (ITC) and molecular modeling. Analysis of fluorescence data showed that the binding between three analogues and FTO occurred via a static quenching mechanism. Both ITC and fluorescence results indicated that 1b is the strongest quencher...
November 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
Jie Wei, Aori Qileng, Yun Yan, Hongtao Lei, Shengsen Zhang, Weipeng Liu, Yingju Liu
An ultrasensitive photoelectrochemical (PEC) immunoassay based on multiple signal amplification strategy was fabricated for the detection of microcystin-LR (MC-LR). The CdS/TiO2 nanorod arrays (CdS/TiO2 NRAs) modified FTO electrode, which can weaken the self-oxidation by photogenerated holes of CdS nanoparticles, and limit the recombination of electron-hole pairs and broaden optical absorption of TiO2 NRAs, was used as a visible-light driven material to immobilize antigens. Then, Fe3O4 nanoparticles/polydopamine (Fe3O4@PDA) was used as the carrier to load secondary antibody (Ab2) and horseradish peroxidase (HRP), where Fe3O4 nanoparticles and HRP can synergistically accelerate the oxidation of 4-chloro-1-naphthol (4-CN) by H2O2 to produce biocatalytic precipitation (BCP) on the surface of modified electrode...
November 22, 2017: Analytica Chimica Acta
Linyong Mao, Yayin Fang, Michael Campbell, William M Southerland
BACKGROUND: Obesity is emerging as a global health problem, with more than one-third of the world's adult population being overweight or obese. In this study, we investigated worldwide population differentiation in allele frequencies of obesity-associated SNPs (single nucleotide polymorphisms). RESULTS: We collected a total of 225 obesity-associated SNPs from a public database. Their population-level allele frequencies were derived based on the genotype data from 1000 Genomes Project (phase 3)...
November 10, 2017: BMC Genomics
Minki Baek, Eun-Ju Kim, Seok Won Hong, Wooyul Kim, Kijung Yong
Due to its high light absorption coefficient and appropriate bandgap, CuInS2 (CIS) has been receiving much attention as an absorber material for thin film solar cells and also as a visible light photocatalyst. Herein we present heterostructured CIS/ZnO nanorods (NRs) in an attempt to enhance light absorption and facilitate charge separation/transfer in the photocatalysis system. CIS nanoparticles (NPs) were directly deposited on ZnO nanorod arrays (NRAs) to fabricate heterostructured CIS/ZnO NRAs using an environmentally benign, non-hydrazine solution reaction...
November 8, 2017: Photochemical & Photobiological Sciences
Tao Wan, Bo Qu, Haiwei Du, Xi Lin, Qianru Lin, Da-Wei Wang, Claudio Cazorla, Sean Li, Sidong Liu, Dewei Chu
Resistive switching behaviour can be classified into digital and analog switching based on its abrupt and gradual resistance change characteristics. Realizing the transition from digital to analog switching in the same device is essential for understanding and controlling the performance of the devices with various switching mechanisms. Here, we investigate the resistive switching in a device made with strontium titanate (SrTiO3) nanoparticles using X-ray diffractometry, scanning electron microscopy, Raman spectroscopy, and direct electrical measurements...
October 31, 2017: Journal of Colloid and Interface Science
Jin Su, Tsutomu Minegishi, Yosuke Kageshima, Hiroyuki Kobayashi, Takashi Hisatomi, Tomohiro Higashi, Masao Katayama, Kazunari Domen
This study investigated the properties of a photoanode fabricated by depositing a p-type CdTe thin film on a CdS-coated FTO substrate (CdTe/CdS/FTO) via close-space sublimation. This CdTe/CdS/FTO electrode was found to work as a photoanode with a long absorption edge wavelength of 830 nm. In a CdTe-based photoanode such as this, the p-n junction formed at the CdTe/CdS interface promotes charge separation of photoexcited carriers and forces photogenerated holes to move toward the photoanode surface to promote oxidation reactions on the electrode surface...
November 9, 2017: Journal of Physical Chemistry Letters
Sadia Ameen, M Nazim, M Shaheer Akhtar, Mohammad Khaja Nazeeruddin, Hyung-Shik Shin
This work highlights the utilization of a novel hole-transporting material (HTM) derived from benzothiadiazole: 4-(3,5-bis(trifluoromethyl)phenyl)-7-(5'-hexyl-[2,2'-bithiophen]-5-yl)benzo[c][1,2,5]thiadiazole (CF-BTz-ThR) and aligned TiO2 nano-bundles (TiO2 NBs) as the electron transporting layer (ETL) for perovskite solar cells (PSCs). The aligned TiO2 NBs were grown on titanium (Ti)-coated FTO substrates using a facile hydrothermal method. The newly designed CF-BTz-ThR molecule with suitable highest occupied molecular orbital (HOMO) favored the effective hole injection from perovskite deposited aligned TiO2 NBs thin film...
November 16, 2017: Nanoscale
Farzaneh Ghafarian Alipour, Shayan Ziaee, Mohamad Reza Ashoori, Mir Saeid Zakeri, Mohammad Ali Boroumand, Naser Aghamohammadzadeh, Maryam Abbasi-Majdi, Fatemeh Shool, Navid Sarakhs Asbaghi, Abolghasem Mohammadi, Nosratollah Zarghami
BACKGROUND AND AIMS: Recent studies show that FTO single nucleotide polymorphisms (SNPs) are associated with obesity and type 2 diabetes mellitus (T2DM). On the other hand, many animal models and clinical studies have demonstrated that apelin, an adipocytokine, is related to the obesity and T2DM. Additionally, obese women are at risk of Hyperandrogenemia. So, the aim of this study was to investigate the relationship between FTO variants (rs763967273, rs759031579, rs141115189, rs9926289, rs76804286 and rs9939609) with T2DM, serum apelin and androgenic hormones in Iranian obese women...
October 31, 2017: Gene
Van-Duong Dao, Van-Tien Bui, Minki Baek, The-Long Phan, Kijung Yong, Ho-Suk Choi
This study reports the fabrication of a Petri dish patterned with cylindrical micro cavity which are produced using a one-step solvent-immersion phase-separation process. The developed 3D honeycomb Petri is coated with Au film through a sputtering method as an efficient Au-coated FTO-free electrode for quantum-dot-sensitized solar cells. Due to the high specific active surface area of the electrode with the Au-coated honeycomb structure, the energy conversion efficiency of devices which use this electrode is 5...
November 2, 2017: Chemistry: a European Journal
Tao Zhong, Xiao-Yue Duan, Hao Zhang, Li Li, Hong-Ping Zhang, Lili Niu
The root of Angelica sinensis (RAS) is a traditional Chinese medicine used for preventing and treating various diseases. In this study, we assessed RAS supplementation effects on body weight and the FTO gene expression and methylation status in a high-fat-diet (HFD) induced obese mouse model. Female obese mice were divided into groups according to RAS dosage in diet as follows: normal diet, HFD diet (HC), HFD with low-dosage RAS (DL), HFD with medium-dosage RAS (DM), and HFD with high-dosage RAS (DH). After RAS supplementation for 4 weeks, body weight suppression and FTO expression in DH mice were significantly higher than in HC mice, whereas no significant change in FTO expression was detected between DM and DL mice or in their offspring...
2017: BioMed Research International
Ramin Saravani, Hamid Reza Galavi, Nafiseh Noorzehi, Nasrin Ranjbar, Fatemeh Mollashahee-Kohkan
BACKGROUND: Perilipins are proteins that coat lipid globules in adipocytes, which are steroid-generating cells that play a central role in lipid storage and breakdown. The FTO gene is associated with type-2 diabetes (T2D) and increased fat mass. In this work the association of perilipin and FTO gene polymorphisms in T2D was investigated. METHODS: One hundred eighty-three Iranian men and women with T2D, and 174 healthy controls with no known metabolic diseases, participated in the study...
October 2017: Reports of Biochemistry & Molecular Biology
Riccardo Zaffaroni, Remko Detz, Jarl Ivar van der Vlugt, Joost Reek
In this contribution, we describe the preparation, characterization and immobilization studies of a benzene dithiolale di-iron hydrogen evolving catalyst, first step towards the development of water splitting devices based on molecular components. FTO (fluorine doped tin oxide), was chosen as the preferred electrode material due to its conductive properties and electrochemical stability. We also report, the use of FTO nano-crystals to greatly improve the surface area of commercially available FTO whilst preserving the properties of the material...
October 27, 2017: ChemSusChem
Nidarshana Chaturvedi Parashar, Gaurav Parashar, Harsh Nayyar, Rajat Sandhir
N(6)-methyl-2'-deoxyadenosine (m6dA) is a well characterized DNA modification in prokaryotes. Its existence in eukaryotic DNA remained doubtful until recently. Evidence suggests that the m6dA levels decrease with the increasing complexity of eukaryotic genomes. Analysis of m6dA levels in genome of lower eukaryotes reveals its role in gene regulation, nucleosome positioning and early development. In higher eukaryotes m6dA is enriched in nongenic region compared to genic region, preferentially in chromosome X and 13 suggesting a chromosome bias...
October 23, 2017: Biochimie
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