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Fat mass and obesity associated gene

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https://www.readbyqxmd.com/read/28803985/mir-199a-3p-affects-adipocytes-differentiation-and-fatty-acid-composition-through-targeting-scd
#1
Zhendong Tan, Jingjing Du, Linyuan Shen, Chendong Liu, Jideng Ma, Lin Bai, Yanzhi Jiang, Guoqing Tang, Mingzhou Li, Xuewei Li, Shunhua Zhang, Li Zhu
Body fat mass is closely associated to diseases related to obesity. MicroRNAs (miRNAs, miR) are important regulatory molecules that function as post-transcriptional gene regulators of adipocyte development. In the current study, we revealed that reduced expression of miR-199a-3p in adipose tissue resulting from high fat diet (HFD)-induced obesity in mice. Overexpression of miR-199a-3p promoted adipocyte proliferation by regulating the expression of regulating factors of the cell cycle. Furthermore, miR-199a-3p blunted lipid accumulation in 3T3-L1 adipocytes...
August 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28793995/transcriptome-profiling-from-adipose-tissue-during-a-low-calorie-diet-reveals-predictors-of-weight-and-glycemic-outcomes-in-obese-nondiabetic-subjects
#2
Claudia Armenise, Gregory Lefebvre, Jérôme Carayol, Sophie Bonnel, Jennifer Bolton, Alessandro Di Cara, Nele Gheldof, Patrick Descombes, Dominique Langin, Wim Hm Saris, Arne Astrup, Jörg Hager, Nathalie Viguerie, Armand Valsesia
Background: A low-calorie diet (LCD) reduces fat mass excess, improves insulin sensitivity, and alters adipose tissue (AT) gene expression, yet the relation with clinical outcomes remains unclear.Objective: We evaluated AT transcriptome alterations during an LCD and the association with weight and glycemic outcomes both at LCD termination and 6 mo after the LCD.Design: Using RNA sequencing (RNAseq), we analyzed transcriptome changes in AT from 191 obese, nondiabetic patients within a multicenter, controlled dietary intervention...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28742883/effects-of-oral-florfenicol-and-azithromycin-on-gut-microbiota-and-adipogenesis-in-mice
#3
Rui Li, Hexing Wang, Qingfeng Shi, Na Wang, Zhijie Zhang, Chenglong Xiong, Jianxiang Liu, Yue Chen, Lufang Jiang, Qingwu Jiang
Certain antibiotics detected in urine are associated with childhood obesity. In the current experimental study, we investigated two representative antibiotics detected in urine, florfenicol and azithromycin, for their early effects on adipogenesis, gut microbiota, short-chain fatty acids (SCFAs), and bile acids in mice. Thirty C57BL/6 mice aged four weeks were randomly divided into three groups (florfenicol, azithromycin and control). The two experimental groups were administered florfenicol or azithromycin at 5 mg/kg/day for four weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28739572/altenusin-a-non-steroidal-microbial-metabolite-attenuates-non-alcoholic-fatty-liver-disease-by-activating-the-farnesoid-x-receptor
#4
Zhihui Zheng, Zanmei Zhao, Shuqiang Li, Xinhua Lu, Mengxi Jiang, Jie Lin, Yunqi An, Yang Xie, Meishu Xu, Wenbin Shen, Grace Guo, YIxian Huang, Song Li, Xuexia Zhang, Wen Xie
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The incidence of NAFLD has increased steadily due to its close association with the global epidemic of obesity and type 2 diabetes. However, there is no effective pharmacological therapy approved for NAFLD. Farnesoid X receptor (FXR), a member of the nuclear receptor subfamily, plays important roles in maintaining the homeostasis of bile acids, glucose and lipids. FXR agonists have shown promise for the treatment of NAFLD. Here we report Altenusin (2076A), a natural non-steroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3...
July 24, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#5
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28720344/apoe-genotype-associates-with-food-consumption-and-body-composition-to-predict-dyslipidaemia-in-brazilian-adults-with-normal-weight-obesity-syndrome
#6
Lana Pacheco Franco, Amanda Gonçalves Zardini Silveira, Rochelle Sobral de Assis Vasconcelos Lima, Maria Aderuza Horst, Cristiane Cominetti
BACKGROUND & AIM: Normal-Weight Obesity Syndrome has been characterized by a normal body mass index and high percentage of body fat. It is associated with an increased risk of cardiovascular disease development. This study aimed to evaluate whether apolipoprotein E (APOE) genotypes and food consumption are related to the lipid profiles of adults with Normal-Weight Obesity Syndrome. METHODS: Analytical cross-sectional study, including adults with Normal-Weight Obesity Syndrome...
July 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28712975/fto-genotype-and-weight-status-among-preadolescents-assessing-the-mediating-effects-of-obesogenic-appetitive-traits
#7
Jennifer A Emond, Alison Tovar, Zhigang Li, Reina K Lansigan, Diane Gilbert-Diamond
Polymorphisms in the Fat Mass and Obesity Associated (FTO) gene are robustly associated with overweight and obesity among children, although the underlying mechanisms are poorly understood. We tested if appetitive traits partially mediated the association between FTO genotype and increased BMI among a sample of US preadolescents. Data were from 178 unrelated 9-10 year olds who participated in an experimental study between 2013 and 2015. Children's DNA was isolated from buccal swabs, and the rs9939609 SNP in the FTO gene was genotyped...
October 1, 2017: Appetite
https://www.readbyqxmd.com/read/28702330/neonatal-glp1r-activation-limits-adult-adiposity-by-durably-altering-hypothalamic-architecture
#8
Andrea V Rozo, Daniella A Babu, PoMan A Suen, David N Groff, Randy J Seeley, Rebecca A Simmons, Patrick Seale, Rexford S Ahima, Doris A Stoffers
OBJECTIVE: Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor (GLP1R) signaling on adult adiposity and metabolism. METHODS: Wild type C57BL/6 mice were injected with 1 nmol/kg Exendin-4 (Ex-4), a GLP1R agonist, for 6 consecutive days after birth...
July 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28690544/lotus-leaf-aqueous-extract-reduces-visceral-fat-mass-and-ameliorates-insulin-resistance-in-hfd-induced-obese-rats-by-regulating-ppar%C3%AE-2-expression
#9
Kemin Yan, Huijuan Zhu, Jian Xu, Hui Pan, Naishi Li, Linjie Wang, Hongbo Yang, Meijuan Liu, FengYing Gong
Objectives: Lotus leaf is a kind of traditional Chinese medicine. We aimed to explore the effects of lotus leaf aqueous extract (LLAE) on peroxisome proliferative activated receptor γ2 (PPARγ2) expression in preadipocytes and adipocytes and further investigate its effects on high fat diet (HFD)-induced obese rats. Methods: pGL3-Enhancer-PPARγ2 (625 bp)-Luc plasmid, a luciferase reporter gene expression plasmid containing PPARγ2 promoter, was stably transfected into 3T3-L1 preadipocytes. PPARγ2 promoter activities were determined by assaying the luciferase activities...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28675894/low-oxygen-consumption-is-related-to-a-hypomethylation-and-an-increased-secretion-of-il-6-in-obese-subjects-with-sleep-apnea-hypopnea-syndrome
#10
Amaya Lopez-Pascual, Arrate Lasa, María P Portillo, Fernando Arós, María L Mansego, Pedro González-Muniesa, J Alfredo Martinez
BACKGROUND: Deoxyribonucleic acid (DNA) methylation is an epigenetic modification involved in gene expression regulation, usually via gene silencing, which contributes to the risks of many multifactorial diseases. The aim of the present study was to analyze the influence of resting oxygen consumption on global and gene DNA methylation as well as protein secretion of inflammatory markers in blood cells from obese subjects with sleep apnea-hypopnea syndrome (SAHS). METHODS: A total of 44 obese participants with SAHS were categorized in 2 groups according to their resting oxygen consumption...
July 4, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28655714/epidermal-growth-factor-receptor-restoration-rescues-the-fatty-liver-regeneration-in-mice
#11
Teresa A Zimmers, Xiaoling Jin, Zongxiu Zhang, Yanlin Jiang, Leonidas G Koniaris
BACKGROUND: Hepatic steatosis is a common histological finding in obese patients. Even mild steatosis is associated with delayed hepatic regeneration and poor outcomes following liver resection or transplantation. We sought to identify and target molecular pathways that mediate this dysfunction. MATERIAL AND METHODS: Lean mice and mice made obese through feeding of a high fat, hyper-caloric diet underwent 70% or 80% hepatectomy. RESULTS: After 70% resection, obese mice demonstrated 100% survival but experienced increased liver injury, reduced energy stores, reduced mitoses, increased necroapoptosis and delayed recovery of liver mass...
June 27, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28636007/analysis-of-association-of-gene-variants-with-obesity-traits-in-new-zealand-european-children-at-6-years-of-age
#12
Mohanraj Krishnan, John M D Thompson, Edwin A Mitchell, Rinki Murphy, Lesley M E McCowan, Andrew N Shelling, G On Behalf Of The Children Of Scope Study Group
Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights into biological factors that contribute to the development of obesity. As obesity tracks through childhood into adulthood, identification of the genetic factors for obesity in early life is important. The objective of this study was to identify putative associations between genetic variants and obesity traits in children at 6 years of age...
July 25, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28626215/genetic-variation-in-the-obesity-gene-fto-is-not-associated-with-decreased-fat-oxidation-the-neo-study
#13
L L Blauw, R Noordam, S Trompet, J F P Berbée, F R Rosendaal, D van Heemst, K W van Dijk, D O Mook-Kanamori, R de Mutsert, P C N Rensen
BACKGROUND: The FTO gene harbours the strongest common genetic variant associated with obesity. Recently, rs1421085-T to -C substitution mapped in FTO was shown to induce a developmental shift of human adipocytes from an energy-combusting beige to an energy-storing white phenotype in vitro. As browning of adipocytes selectively enhances fat oxidation (FatOx), we hypothesized that rs1421085-C in FTO is associated with deceased FatOx compared with carbohydrate oxidation (CarbOx) and an increased respiratory quotient (RQ)...
June 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28626026/protein-kinase-c%C3%AE-activates-fat-mass-and-obesity-associated-protein-by-influencing-its-ubiquitin-proteasome-degradation
#14
Haoran Tai, Xiaobo Wang, Jiao Zhou, Xiaojuan Han, Tingting Fang, Hui Gong, Ning Huang, Honghan Chen, Jianqiong Qin, Ming Yang, Xiawei Wei, Li Yang, Hengyi Xiao
PKCβ is a serine-threonine kinase associated with obesity and diabetic complications; its activation contributes to weight gain, and deletion of its gene results in resistance to genetic- and diet-induced obesity. Fat mass and obesity-associated (FTO) protein is a recently identified RNA demethylase, and its overexpression in mice leads to increased body weight as well as fat mass. Although sharing some features in anabolism regulation, PKCβ and FTO have not been investigated together; therefore, their relationship has not been established...
June 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28619249/metabolism-of-sex-steroids-is-influenced-by-acquired-adiposity-a-study-of-young-adult-male-monozygotic-twin-pairs
#15
Veera Vihma, Jussi Naukkarinen, Ursula Turpeinen, Esa Hämäläinen, Jaakko Kaprio, Aila Rissanen, Sini Heinonen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Tomi S Mikkola, Matti J Tikkanen, Kirsi H Pietiläinen
Obesity and ageing are associated with lower serum testosterone levels in men. How fat distribution or adipose tissue metabolism, independent of genetic factors and age, are related to sex steroid metabolism is less clear. We studied the associations between adiposity and serum sex hormone concentrations, and mRNA expression of genes regulating sex hormone metabolism in adipose tissue in young adult male monozygotic (MZ) twin pairs. The subjects [n=18 pairs; mean age, 32 years; individual body mass indexes (BMIs) 22-36kg/m(2)] included 9 male MZ twin pairs discordant for BMI [intra-pair difference (Δ) in BMI ≥3kg/m(2)]...
September 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28607773/fto-gene-associates-and-interacts-with-obesity-risk-physical-activity-energy-intake-and-time-spent-sitting-pilot-study-in-a-nigerian-population
#16
Bolaji Fatai Oyeyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, Nanfizat Abiket Alamukii
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28607568/review-of-studies-on-the-fat-mass-and-obesity-associated-fto-gene-interactions-with-environmental-factors-affecting-on-obesity-and-its-impact-on-lifestyle-interventions
#17
REVIEW
Naser Kalantari, Saeid Doaei, Nastaran Keshavarz-Mohammadi, Maryam Gholamalizadeh, Naeimeh Pazan
BACKGROUND: The prevalence of obesity is influenced by environmental and genetic factors. Recently, it has been reported that an interaction between genotype and environmental factors can affect each other's effects on the phenotype. The purpose of this study is to evaluate the recent studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and the impact of these interactions on the success level of the lifestyle intervention...
November 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28603074/fto-gene-polymorphisms-rs9939609-and-rs17817449-as-predictors-of-type-2-diabetes-mellitus-in-obese-iraqi-population
#18
Laith A Younus, Abdul Hussein A Algenabi, Mohammed S Abdul-Zhara, Majid K Hussein
BACKGROUND: The variation of the SNPs in FTO (fat mass and obesity associated) gene are improved to be associated with obesity and type 2 diabetes (T2DM) in some ethnic groups for example in European while, this consistency is controversial in Asians and there were few studies in Iraqi population about the effect of this gene on the development of T2DM in obese patients. Therefore, the objective of this study is to investigate the impact of the two common FTO gene variants in the development of T2DM in obese Iraqi patients...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28601987/the-association-of-snp276g-t-at-adiponectin-gene-with-insulin-resistance-and-circulating-adiponectin-in-morbid-obese-patients-after-a-biliopancreatic-diversion-surgery
#19
Daniel Antonio de Luis, David Pacheco, D Primo, Olatz Izaola, R Aller
BACKGROUND: The effects of rs1501299 variant of ADIPO gene on weight loss after bariatric surgery have not been evaluated. We decided to investigate the role of this genetic variant on anthropometric and biochemical outcomes such as serum adiponectin levels after biliopancreatic diversion (BPD) surgery in morbidly obese patients during 3 years. MATERIAL AND METHODS: A sample of 64 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (1, 2, and 3 years)...
June 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28599470/the-lipid-metabolism-gene-fto-influences-breast-cancer-cell-energy-metabolism-via-the-pi3k-akt-signaling-pathway
#20
Yazhuo Liu, Ruoyu Wang, Lichuan Zhang, Jianhua Li, Keli Lou, Bingyin Shi
The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA from breast cancer cells and normal breast cells. MDA-MB-231 cells were transfected with miFTO inhibitor or inhibitor control, and cells were assessed for levels of lactic acid, ATP, pyruvate kinase activity, and hexokinase activity assay using specific kits...
June 2017: Oncology Letters
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