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Fat mass and obesity associated gene

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https://www.readbyqxmd.com/read/29334686/fat-mass-and-obesity-related-gene-variants-rs9939609-and-rs7185735-are-associated-with-second-generation-antipsychotic-induced-weight-gain
#1
Charlotte Schröder, Fabian Czerwensky, Stefan Leucht, Werner Steimer
INTRODUCTION: Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy. METHODS: We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were included in a naturalistic study. RESULTS: After 4 weeks of treatment, we did not observe any significant association of polymorphisms with weight change in the whole study population (p>0...
January 15, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29325772/the-association-of-snp276g-t-at-adiponectin-gene-with-insulin-resistance-and-circulating-adiponectin-in-response-to-two-different-hypocaloric-diets
#2
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller, A Ortola, E Gómez, J J Lopez
BACKGROUND: Several adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPS) have been related with adiponectin levels and risk for obesity. OBJECTIVE: The aim of our study was to analyze the effect of rs1501299 ADIPOQ gene polymorphism and dietary intake on total adiponectin levels and insulin resistance after two hypocaloric diets in obese subjects. MATERIAL AND METHODS: A Caucasian population of 284 obese patients was enrolled in a randomized clinical trial with two hypocaloric diets (I: moderate carbohydrates vs II: low fat)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325734/fat-mass-and-obesity-associated-gene-rs9939609-polymorphism-is-a-potential-biomarker-of-recurrent-venous-thromboembolism-in-male-but-not-in-female-patients
#3
Abrar Ahmad, Ashfaque A Memon, Jan Sundquist, Peter J Svensson, Bengt Zöller, Kristina Sundquist
Multiple genetic variations have been identified in FTO (fat mass and obesity-associated) gene. Among them, FTO rs9939609 polymorphism is shown to be associated with the risk of primary venous thromboembolism (VTE). However, its role in recurrent VTE is not known. The aim of our study was to investigate the association between FTO rs9939609 polymorphism and the risk of VTE recurrence in a prospective follow-up study in both male and female patients. FTO rs9939609 polymorphism (T/A) was analyzed in the Malmö thrombophilia study (MATS, followed for ~10 years) by using TaqMan PCR...
January 8, 2018: Gene
https://www.readbyqxmd.com/read/29318723/endothelium-specific-cyp2j2-overexpression-attenuates-age-related-insulin-resistance
#4
Yan Yang, Ruolan Dong, Zhihui Chen, Danli Hu, Menglu Fu, Ying Tang, Dao Wen Wang, Xizhen Xu, Ling Tu
Ample evidences demonstrate that cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids (EETs) exert diverse biological activities, which include potent vasodilatory, anti-inflammatory, and cardiovascular protective effects. In this study, we investigated the effects of endothelium-specific CYP2J2 overexpression on age-related insulin resistance and metabolic dysfunction. Endothelium-specific targeting of the human CYP epoxygenase, CYP2J2, transgenic mice (Tie2-CYP2J2-Tr mice) was utilized. The effects of endothelium-specific CYP2J2 overexpression on aging-associated obesity, inflammation, and peripheral insulin resistance were evaluated by assessing metabolic parameters in young (3 months old) and aged (16 months old) adult male Tie2-CYP2J2-Tr mice...
January 10, 2018: Aging Cell
https://www.readbyqxmd.com/read/29317321/differential-distribution-and-association-of-fto-rs9939609-gene-polymorphism-with-obesity-a-cross-sectional-study-among-two-tribal-populations-of-india-with-east-asian-ancestry
#5
Somorjit Singh Ningombam, Varhlun Chhungi, Masan Kambo Newmei, Sunanda Rajkumari, Naorem Kiranmala Devi, Prakash Ranjan Mondal, Kallur Nava Saraswathy
The fat mass and obesity associated (FTO) rs9939609 gene polymorphism is most widely studied in terms of obesity in various populations. Recently, the prevalence of obesity has been reported to be very high among the North-Eastern State of India. The major aim of the present study is to understand the extent of FTO rs9939609 gene polymorphism and its association with obesity among the two North-East Indian tribal populations with similar East Asian ancestry. Somatometric data and fasting blood sample were collected from 521 tribal individuals (258 Liangmai and 263 Mizo) of Manipur after obtaining written informed consent...
January 6, 2018: Gene
https://www.readbyqxmd.com/read/29315078/associations-between-the-components-of-metabolic-syndrome-and-the-polymorphisms-in-the-peroxisome-proliferator-activated-receptor-gamma-ppar-%C3%AE-the-fat-mass-and-obesity-associated-fto-and-the-melanocortin-4-receptor-mc4r-genes
#6
Małgorzata Szkup, Aleksander Jerzy Owczarek, Daria Schneider-Matyka, Jacek Brodowski, Beata Łój, Elżbieta Grochans
INTRODUCTION: Metabolic syndrome (MetS) is regarded as a set of abnormalities, increasing the risk of serious functioning disorders. It can develop as a result of genetic predisposition. AIM: The aim of this study was to establish associations between MetS-related abnormalities and the PPAR-γ rs1801282, FTO rs9939609, and MC4R rs17782313 polymorphisms. MATERIAL AND METHODS: The study involved 425 women aged 45-60 years. The participants were surveyed and subjected to anthropometric, biochemical and genetic analysis...
January 9, 2018: Aging
https://www.readbyqxmd.com/read/29296046/the-association-of-serum-leptin-levels-with-metabolic-diseases
#7
REVIEW
Jen-Pi Tsai
Leptin is a 167-amino-acid protein released by white adipose tissue and encoded by the obese gene. It has a role as a negative regulator of appetite control through sending a satiety signal to act on receptors within the hypothalamus. At normal levels, leptin can exert its effects on weight regulation according to white fat mass, induce sodium excretion, maintain vascular tone, and repair the myocardium. Beyond these effects, elevated serum leptin levels have been implicated in the pathogenesis of metabolic syndrome, diabetes mellitus, hypertension, and multiple cardiovascular diseases...
October 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29285243/high-visceral-fat-percentage-is-associated-with-poor-outcome-in-endometrial-cancer
#8
Karen Klepsland Mauland, Øyvin Eng, Sigmund Ytre-Hauge, Ingvild L Tangen, Anna Berg, Helga B Salvesen, Øyvind O Salvesen, Camilla Krakstad, Jone Trovik, Erling A Hoivik, Henrica Maria Johanna Werner, Gunnar Mellgren, Ingfrid S Haldorsen
Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution quantified by computed tomography (CT), in relation to tumor characteristics and outcome. 227 EC patients with preoperative abdominal CT scans were included. Total abdominal fat volume (TAV), subcutaneous abdominal fat volume (SAV) and visceral abdominal fat volume (VAV) were quantified, and visceral fat percentage calculated (VAV%=[VAV/TAV]x100)...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29280647/-relation-of-variant-rs180077-of-gen-cholesterol-ester-transfer-protein-variant-with-fat-mass-hdl-cholesterol-in-obese-subjects-with-diabetes-mellitus-type-2
#9
Daniel Antonio De Luis, Olatz Izaola, David Primo, Susana García Calvo, Emilia Gómez Hoyos, Juan José López Gómez, Ana Ortola, Cristina Serrano, Esther Delgado, Beatriz Torres Torres
BACKGROUND: There is few evidence of cholesterol ester transfer protein (CETP) in subjects with obesity and diabetes mellitus. OBJECTIVES: We examined the association of the polymorphism (rs1800777) of CETP gene on anthropometric parameters, lipid profile and adipokines in subjects with obesity and diabetes mellitus type 2. MATERIAL AND METHODS: A population of 229 obese subjects with diabetes mellitus type 2 was enrolled. An electrical bioimpedance, blood pressure, dietary intake, exercise and biochemical analyses were recorded...
November 14, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29277345/implication-of-the-rs670-variant-of-apoa1-gene-with-lipid-profile-serum-adipokine-levels-and-components-of-metabolic-syndrome-in-adult-obese-subjects
#10
Daniel Antonio de Luis, Olatz Izaola, David Primo, Rocio Aller
BACKGROUND & AIMS: A G-to-A transition located 75 base pairs upstream (rs670) from transcription start site of the APOA1 gene is related with metabolic parameters. The aim of the present investigation was to describe the association of rs670 with metabolic syndrome and metabolic parameters. METHODS: The study involved a population of 1000 obese subjects. Measurements of anthropometric parameters, arterial blood pressure, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), lipid profile, adipokines levels and prevalence of MetS was recorded...
December 15, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29273742/the-interaction-of-fat-mass-and-obesity-associated-gene-polymorphisms-and-dietary-fiber-intake-in-relation-to-obesity-phenotypes
#11
Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S Daneshpour, Parvin Mirmiran, Bahareh Sedaghati-Khayat, Fereidoun Azizi
Controversies surrounding the effectiveness of fiber intake for prevention of obesity can be attributed to differences in the genetic makeup of individuals. This study aims to examining the interaction between dietary fiber intake and common fat mass and obesity-associated (FTO) single-nucleotide polymorphisms (SNPs), in relation to obesity. Subjects of this nested case-control study were selected from among adult participants of the Tehran Lipid and Glucose Study. Cases (n = 627) were individually matched with controls, who had normal weight...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29273198/enlarged-adipocytes-in-subcutaneous-adipose-tissue-associated-to-hyperandrogenism-and-visceral-adipose-tissue-volume-in-women-with-polycystic-ovary-syndrome
#12
Bárbara Echiburú, Francisco Pérez-Bravo, José E Galgani, Daniel Sandoval, Carolina Saldías, Nicolás Crisosto, Manuel Maliqueo, Teresa Sir-Petermann
CONTEXT: Polycystic ovary syndrome (PCOS) is an androgen excess disorder associated with obesity and adipose tissue disturbances. Our aim was to evaluate gene expression of adipocytokines and adipocyte characteristics in abdominal subcutaneous adipose tissue (SAT) of PCOS women. DESIGN: Twelve PCOS (PCOSw) and 12 control (Cw) premenopausal women (BMI 20-35 kg/m2) were included, with measurements of whole-body composition assessed by dual-energy X-ray absorptiometry, and abdominal subcutaneous and visceral adipose tissue (VAT) volume, by magnetic resonance imaging...
February 2018: Steroids
https://www.readbyqxmd.com/read/29238857/fto-rs9939609-a-allele-influences-anthropometric-outcome-in-response-to-dietary-intervention-but-not-in-response-to-physical-exercise-program
#13
Gabrielle Araujo do Nascimento, Mayza Dalcin Teixeira, Lupe Furtado-Alle, Neiva Leite, Ricardo Lehtonen Rodrigues de Souza, Louise Farah Saliba, Gerusa Eisfeld Milano, Larissa Rosa da Silva, Juliana Pizzi, Wendell Arthur Lopes, Maria de Fátima Aguiar Lopes, Ana Cláudia Kapp Titski, Luciane Viater Tureck
PURPOSE: The fat mass and obesity-associated (FTO) gene is involved in energy homeostasis. The A allele of the rs9939609 (SNP; T>A) is associated with obesity and higher food intake, while its effect in energy expenditure remains unclear. The aim of this study is to examine whether FTO rs9939609 is associated with the anthropometric outcomes of a physical exercise program and a dietary intervention. METHODS: We studied two independent samples. The first was composed by children and adolescents in which overweight and obese individuals were submitted to a physical exercise program (n = 136) and normal weight participants served as a control group (n = 172)...
December 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29237556/ubiquitination-regulates-the-proteasomal-degradation-and-nuclear-translocation-of-the-fat-mass-and-obesity-associated-fto-protein
#14
Tianyi Zhu, Xuan Ling Hilary Yong, Xia Di, Jocelyn Widagdo, Victor Anggono
Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food intake and body weight. Although the proteasome system is involved, the cellular mechanism underlying FTO protein turnover remains unknown. Here, we report that FTO undergoes post-translational ubiquitination on Lys-216. Knock-in HeLa cells harboring the ubiquitin-deficient K216R mutation displayed a slower rate of FTO turnover, resulting in an increase in the level of FTO as well as enhanced phosphorylation of the ribosomal S6 kinase...
December 10, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29233619/fto-affects-food-cravings-and-interacts-with-age-to-influence-age-related-decline-in-food-cravings
#15
Linh C Dang, Gregory R Samanez-Larkin, Christopher T Smith, Jaime J Castrellon, Scott F Perkins, Ronald L Cowan, Daniel O Claassen, David H Zald
The fat mass and obesity associated gene (FTO) was the first gene identified by genome-wide association studies to correlate with higher body mass index (BMI) and increased odds of obesity. FTO remains the locus with the largest and most replicated effect on body weight, but the mechanism whereby FTO affects body weight and the development of obesity is not fully understood. Here we tested whether FTO is associated with differences in food cravings and a key aspect of dopamine function that has been hypothesized to influence food reward mechanisms...
December 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29228687/interactions-between-rasa2-cadm1-hif1an-gene-polymorphisms-and-body-fatness-with-breast-cancer-a-population-based-case-control-study-in-china
#16
Zheng Zhu, Zhimei Teng, Fränzel J B van Duijnhoven, Meihua Dong, Yun Qian, Hao Yu, Jie Yang, Renqiang Han, Jian Su, Wencong Du, Xingyu Huang, Jinyi Zhou, Xiaojin Yu, Ellen Kampman, Ming Wu
Genome-wide association studies (GWAS) have indicated that gene polymorphisms in alleles of RAS p21 protein activator 2 (RASA2), cell adhesion molecule 1 (CADM1) and hypoxia inducible factor 1 alpha subunit inhibitor (HIF1AN) are associated with the risk of obesity. In this study, we explored the interactions between candidate SNPs of RASA2 (rs16851483), CADM1 (rs12286929) and HIF1AN (rs17094222) and body fatness for breast cancer risk. Unconditional logistic regression models were applied to measure the associations of related factors with breast cancer by odds ratios (ORs) and 95% confidence intervals (CIs)...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212073/age-induced-changes-in-white-brite-and-brown-adipose-depots-a-mini-review
#17
Markus Schosserer, Johannes Grillari, Christian Wolfrum, Marcel Scheideler
Aging is a time-related process of functional decline at organelle, cellular, tissue, and organismal level that ultimately limits life. Cellular senescence is a state of permanent growth arrest in response to stress and one of the major drivers of aging and age-related disorders. Senescent cells accumulate with age, and removal of these cells delays age-related disorders in different tissues and prolongs healthy lifespan. One of the most studied aging mechanisms is the accumulation of reactive oxygen species damage in cells, organs, and organisms over time...
December 7, 2017: Gerontology
https://www.readbyqxmd.com/read/29193738/cooperative-role-of-the-glp-1-receptor-and-%C3%AE-3-adrenergic-mediated-signaling-on-fat-mass-reduction-through-the-down-regulation-of-pka-akt-ampk-signaling-in-the-adipose-tissue-and-muscle-of-rats
#18
Juan Decara, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Carlos Dieguez, Rubén Nogueiras, Fernando Rodríguez de Fonseca, Juan Suárez
AIM: To explore the cooperation of GLP-1 receptor and β3-adrenergic receptor-mediated signaling in the control of fat mass/feeding behavior by studying the effects of a combined therapy composed of the GLP-1R agonist liraglutide and the β3-AR agonist CL316243. METHODS: The study included the analysis of key mechanisms regulating lipid/cholesterol metabolism, and thermogenesis in brown (BAT) and epididymal white (eWAT) adipose tissues, abdominal muscle and liver of male rats...
November 28, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29192516/knockdown-of-angiopoietin-like-2-mimics-the-benefits-of-intermittent-fasting-on-insulin-responsiveness-and-weight-loss
#19
Cécile Martel, Anthony Pinçon, Alexandre Maxime Bélanger, Xiaoyan Luo, Marc-Antoine Gillis, Olivia de Montgolfier, Nathalie Thorin-Trescases, Éric Thorin
Angiopoietin-like 2 (ANGPTL2) is an inflammatory adipokine linking obesity to insulin resistance. Intermittent fasting, on the other hand, is a lifestyle intervention able to prevent obesity and diabetes but difficult to implement and maintain. Our objectives were to characterize a link between ANGPTL2 and intermittent fasting and to investigate whether the knockdown of ANGPTL2 reproduces the benefits of intermittent fasting on weight gain and insulin responsiveness in knockdown and wild-type littermates mice...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29174029/interrelationship-of-the-rs7903146-tcf7l2-gene-variant-with-measures-of-glucose-metabolism-and-adiposity-the-neo-study
#20
R Noordam, C P A Zwetsloot, R de Mutsert, D O Mook-Kanamori, H J Lamb, A de Roos, E J P de Koning, F R Rosendaal, K Willems van Dijk, D van Heemst
BACKGROUND AND AIMS: We investigated the interrelationship of rs7903146-T in TCF7L2 with measures of glucose metabolism and measures of adiposity. METHODS AND RESULTS: This cross-sectional analysis was conducted in 5744 middle-aged participants (mean (standard deviation [SD]) age is 55.9 (6.0) years) from the Netherlands Epidemiology of Obesity (NEO) Study. Associations between rs7903146-T and Type 2 diabetes mellitus (T2D) were assessed with logistic regression...
October 18, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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