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Fat mass and obesity associated gene

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https://www.readbyqxmd.com/read/28420164/the-angiogenesis-inhibitor-als-l1023-from-lemon-balm-leaves-attenuates-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-through-regulating-the-visceral-adipose-tissue-function
#1
Jeongjun Kim, Haerim Lee, Jonghoon Lim, Jaeho Oh, Soon Shik Shin, Michung Yoon
Similar to neoplastic tissues, growth and development of adipose tissue are thought to be angiogenesis-dependent. Since visceral adipose tissue (VAT) is associated with development and progression of nonalcoholic fatty liver disease (NAFLD), we hypothesized that angiogenesis inhibition would attenuate obesity-induced NAFLD. We fed C57BL/6J mice a low-fat diet (LFD, chow 10% kcal fat), a high-fat diet (HFD, 45% kcal fat) or HFD supplemented with the lemon-balm extract ALS-L1023 (HFD-ALS) for 15 weeks. ALS-L1023 reduced endothelial cell-tube formation in vitro...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28415622/is-fto-gene-variant-related-to-cancer-risk-independently-of-adiposity-an-updated-meta-analysis-of-129-467-cases-and-290-633-controls
#2
Yu Kang, Fang Liu, Yao Liu
Previous studies have examined the association between the fat mass and obesity-associated (FTO) gene variant and risk of cancer in diverse populations. However, the results have been inconsistent. PubMed and Embase databases were searched for the eligible publications in English language by July, 2016. The associations of FTO variants with cancer risk were estimated by calculating the pooled odds ratios and 95% confidence intervals by meta-analyses. A total of 27 publications (129,467 cancer cases and 290,633 normal controls) were included in our meta-analysis...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402022/steroidogenic-acute-regulatory-protein-star-overexpression-reduces-inflammation-and-insulin-resistance-in-obese-mice
#3
Yanyan Qiu, Xianxian Sui, Shengxuan Cao, Xiaobo Li, Yanxia Ning, Songmei Wang, Lianhua Yin, Xiuling Zhi
Steroidogenic acute regulatory protein (StAR), a mitochondrial cholesterol delivery protein, plays a beneficial role in hyperlipidemia, NAFLD and endothelial inflammation. Elevated circulating fatty acids and low grade inflammation are known as key risk factors of insulin resistance and type 2 diabetes. In the present study, C57BL/6J mice were fed with a HFD and infected with recombinant adenovirus expressing StAR by tail-vein injection. Intraperitoneal glucose/insulin tolerance test was performed to assess the insulin sensitivity...
April 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28400497/c57bl-6j-mice-as-a-polygenic-developmental-model-of-diet-induced-obesity
#4
Dinh-Toi Chu, Elzbieta Malinowska, Magdalena Jura, Leslie P Kozak
Susceptibility to obesity changes during the course of life. We utilized the C57BL/6J (B6) and 129S mouse as a genetic model for variation in diet-induced obesity to define the adiposity phenotypes from birth to maturity at 8 weeks-of-age. From birth to 8 weeks-of-age, both male and female 129S mice had significantly higher fat mass and adiposity index than B6 mice, although they were not obese. After 8 weeks-of-age, B6 had greater adiposity/obesity than 129S mice in response to a high fat (HF). We sought to determine the mechanism activating the fat accumulation in B6 mice at 8-weeks-of-age...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28398475/fat-mass-and-obesity-associated-fto-protein-regulates-adult-neurogenesis
#5
Liping Li, Liqun Zang, Feiran Zhang, Junchen Chen, Hui Shen, Liqi Shu, Feng Liang, Chunyue Feng, Deng Chen, Huikang Tao, Tianlei Xu, Ziyi Li, Yunhee Kang, Hao Wu, Lichun Tang, Pumin Zhang, Peng Jin, Qiang Shu, Xuekun Li
Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability. The role of FTO in neurodevelopment and neurogenesis, however, remains largely unknown. Here we show that FTO is expressed in adult neural stem cells and neurons and displays dynamic expression during postnatal neurodevelopment. The loss of FTO leads to decreased brain size and body weight. We find that FTO deficiency could reduce the proliferation and neuronal differentiation of adult neural stem cells in vivo, which leads to impaired learning and memory...
April 7, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28381478/can-genetic-based-advice-help-you-lose-weight-findings-from-the-food4me-european-randomized-controlled-trial
#6
Carlos Celis-Morales, Cyril Fm Marsaux, Katherine M Livingstone, Santiago Navas-Carretero, Rodrigo San-Cristobal, Rosalind Fallaize, Anna L Macready, Clare O'Donovan, Clara Woolhead, Hannah Forster, Silvia Kolossa, Hannelore Daniel, George Moschonis, Christina Mavrogianni, Yannis Manios, Agnieszka Surwillo, Iwona Traczyk, Christian A Drevon, Keith Grimaldi, Jildau Bouwman, Mike J Gibney, Marianne C Walsh, Eileen R Gibney, Lorraine Brennan, Julie A Lovegrove, J Alfredo Martinez, Wim Hm Saris, John C Mathers
Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis...
April 5, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28360946/associations-of-lep-crh-icam-1-and-line-1-methylation-measured-in-saliva-with-waist-circumference-body-mass-index-and-percent-body-fat-in-mid-childhood
#7
Jocelyn Dunstan, Joseph P Bressler, Timothy H Moran, Jonathan S Pollak, Annemarie G Hirsch, Lisa Bailey-Davis, Thomas A Glass, Brian S Schwartz
BACKGROUND: Genetics explains a small proportion of variance in body mass index at the population level. Epigenetics, commonly measured by gene methylation, holds promise for understanding obesity risk factors and mechanisms. METHODS: Participants were 431 adolescents aged 10-15 years. BMI z-score, waist circumference z-score, and percent body fat were measured. Saliva samples were collected and methylation of promoter regions of four candidate genes or sequences (LEP, ICAM-1, CRH, and LINE-1) were measured in 3-4 CpG sites each...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28357924/association-study-of-the-fto-gene-polymorphisms-with-the-risk-of-pulmonary-tuberculosis-in-a-sample-of-iranian-population
#8
Mohammad Naderi, Mohammad Hashemi, Nahid Dejkam, Gholamreza Bahari, Maryam Rezaei, Mohsen Taheri
AIM: The aim of the present study was to find out the impact of fat mass and obesity-associated (FTO) gene on risk of pulmonary tuberculosis (PTB) in a sample of Iranian population. METHODS: This case-control study was carried out on a total of 354 subjects including 185 PTB patients and 169 healthy subjects. Genotyping of FTO rs9939609 and rs8050136 variants was done using polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: FTO rs9939609 variant showed no statistically significant difference in allele and genotype frequencies between PTB patients and controls...
March 1, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28333151/fto-is-required-for-myogenesis-by-positively-regulating-mtor-pgc-1%C3%AE-pathway-mediated-mitochondria-biogenesis
#9
Xiaobo Wang, Ning Huang, Min Yang, Dandan Wei, Haoran Tai, Xiaojuan Han, Hui Gong, Jiao Zhou, Jianqiong Qin, Xiawei Wei, Honghan Chen, Tingting Fang, Hengyi Xiao
Global germ line loss of fat mass- and obesity-associated (FTO) gene results in both the reduction of fat mass and lean mass in mice. The role of FTO in adipogenesis has been proposed, however, that in myogenesis has not. Skeletal muscle is the main component of body lean mass, so its connection with FTO physiologic significance need to be clarified. Here, we assessed the impact of FTO on murine skeletal muscle differentiation by in vitro and in vivo experiments. We found that FTO expression increased during myoblasts differentiation, while the silence of FTO inhibited the differentiation; in addition, skeletal muscle development was impaired in skeletal muscle FTO-deficient mice...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28294290/genetic-obesity-risk-and-attenuation-effect-of-physical-fitness-in-mexican-mestizo-population-a-case-control-study
#10
Paula Costa-Urrutia, Carolina Abud, Valentina Franco-Trecu, Valentina Colistro, Martha Eunice Rodríguez-Arellano, Joel Vázquez-Pérez, Julio Granados, Marilia Seelaender
We analyzed commonly reported European and Asian obesity-related gene variants in a Mexican-Mestizo population through each single nucleotide polymorphism (SNP) and a genetic risk score (GRS) based on 23 selected SNPs. Study subjects were physically active Mexican-Mestizo adults (n  =  608) with body mass index (BMI) values from 18 to 55 kg/m(2) . For each SNP and for the GRS, logistic models were performed to test for simple SNP associations with BMI, fat mass percentage (FMP), waist circumference (WC), and the interaction with VO2max and muscular endurance (ME)...
March 15, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28294082/genetics-of-fat-intake-in-the-determination-of-body-mass
#11
Agata Chmurzynska, Monika A Mlodzik
Body mass and fat intake are multifactorial traits that have genetic and environmental components. The gene with the greatest effect on body mass is FTO (fat mass and obesity-associated), but several studies have shown that the effect of FTO (and of other genes) on body mass can be modified by the intake of nutrients. The so-called gene-environment interactions may also be important for the effectiveness of weight-loss strategies. Food choices, and thus fat intake, depend to some extent on individual preferences...
March 15, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28288181/nucleocytoplasmic-shuttling-of-fto-does-not-affect-starvation-induced-autophagy
#12
Aleksander Aas, Pauline Isakson, Christian Bindesbøll, Endalkachew A Alemu, Arne Klungland, Anne Simonsen
Polymorphic variants of the FTO (fat mass and obesity) gene associate with body mass index in humans, but the underlying molecular mechanisms have not been firmly determined. FTO is linked to energy homeostasis via amino acid sensing and is thought to activate the mammalian target of rapamycin complex 1, a negative regulator of autophagy. FTO localises both to the nucleus and the cytoplasm, and in this study we identify a functional nuclear localisation signal (NLS) in the N-terminus of FTO, as well as nuclear localization information in its very C-terminus...
2017: PloS One
https://www.readbyqxmd.com/read/28288167/erythropoietin-epo-ameliorates-obesity-and-glucose-homeostasis-by-promoting-thermogenesis-and-endocrine-function-of-classical-brown-adipose-tissue-bat-in-diet-induced-obese-mice
#13
Kazuki Kodo, Satoru Sugimoto, Hisakazu Nakajima, Jun Mori, Ikuyo Itoh, Shota Fukuhara, Keiichi Shigehara, Taichiro Nishikawa, Kitaro Kosaka, Hajime Hosoi
Erythropoietin (EPO), clinically used as a hematopoietic drug, has received much attention due to its nonhematopoietic effects. EPO reportedly has beneficial effects on obesity and diabetes mellitus. We investigated whether interscapular brown adipose tissue (iBAT: main part of classical BAT) could play a role in EPO's anti-obesity and anti-diabetic effects in diet-induced obese mice. Four-week-old male C57BL/6J mice were fed a high-fat diet (HFD-Con), and half were additionally given an intraperitoneal injection of recombinant human EPO (200 IU/kg) (HFD-EPO) thrice a week for four weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28283271/multiple-chemical-sensitivity-genotypic-characterization-nutritional-status-and-quality-of-life-in-52-patients
#14
Viviana Loria-Kohen, Helena Marcos-Pasero, Rocío de la Iglesia, Elena Aguilar-Aguilar, Isabel Espinosa-Salinas, Jesús Herranz, Ana Ramírez de Molina, Guillermo Reglero
BACKGROUND AND OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic, multisystem syndrome of unknown etiology. The aim of the present study was to describe the nutritional status and quality of life of patients suffering from MCS, as well as to identify potential polymorphisms associated with this illness. PATIENTS AND METHODS: A cross-sectional, descriptive study was performed on patients with a diagnosis of MCS. Data on anthropometric and body composition variables, hand muscle strength and quality of life were collected...
March 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28282466/fat-mass-and-obesity-associated-gene-fto-is-associated-to-eating-disorders-susceptibility-and-moderates-the-expression-of-psychopathological-traits
#15
Giovanni Castellini, Marica Franzago, Silvia Bagnoli, Lorenzo Lelli, Michela Balsamo, Milena Mancini, Benedetta Nacmias, Valdo Ricca, Sandro Sorbi, Ivana Antonucci, Liborio Stuppia, Giovanni Stanghellini
Eating Disorders (EDs) show a multifactorial etiopathogenesis including environmental, psychological and biological factors. In the present study, we propose a model of interactions between genetic vulnerability-represented by Fat Mass and Obesity-Associated (FTO) gene-and stable psychopathological traits, such as bodily disorders and emotion dysregulation for EDs patients. The distribution of a polymorphism of the FTO (rs9939609 T>A) was evaluated in a series of 250 EDs patients and in a group of 119 healthy control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28257836/association-analysis-of-fto-gene-polymorphisms-with-obesity-in-greek-adults
#16
Yiannis Goutzelas, Kalliopi Kotsa, Yiannis Vasilopoulos, Xanthippi Tsekmekidou, Costas Stamatis, John G Yovos, Theologia Sarafidou, Zissis Mamuris
Nowadays, obesity is the greatest scourge worldwide, particularly for the developed countries and is a huge burden for the public health. Over the past decade, GWAS have revealed a number of genes associated with obesity. The fat mass and obesity associated (FTO) gene was the first one associated with obesity in a significant number of populations and recent meta-analysis studies confirm this association. FTO is a N-methyladenosine demethylase and in addition to the genetic association, its biological role in the regulation of body weight has been documented...
May 20, 2017: Gene
https://www.readbyqxmd.com/read/28253220/fat-mass-and-obesity-associated-protein-attenuates-lipid-accumulation-in-macrophage-foam-cells-and-alleviates-atherosclerosis-in-apolipoprotein-e-deficient-mice
#17
Chunfen Mo, Ming Yang, Xiaojuan Han, Junhong Li, Guangping Gao, Haoran Tai, Ning Huang, Hengyi Xiao
OBJECTIVE: Genome-wide association studies have linked variants of fat mass and obesity-associated protein (FTO) to obesity. However, the molecular function of FTO remains unclear. In this study, we sought to investigate the potential effects of FTO in modulating cholesterol deposition in macrophage foam cells, as well as whether FTO exerts antiatherosclerotic properties in apolipoprotein E-deficient mice. METHOD AND RESULTS: We transfected RAW264.7 cells with plasmids encoding a wild-type or mutant FTO gene (I367F)...
April 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28244985/high-bmi-levels-associate-with-reduced-mrna-expression-of-il10-and-increased-mrna-expression-of-inos-nos2-in-human-frontal-cortex
#18
J K Lauridsen, R H Olesen, J Vendelbo, T M Hyde, J E Kleinman, B M Bibby, B Brock, J Rungby, A Larsen
Several studies link increasing body mass index (BMI) to cognitive decline both as a consequence of obesity per se and as a sequela of obesity-induced type 2 diabetes. Obese individuals are prone to a chronic low-grade inflammation as the metabolically active visceral fat produces proinflammatory cytokines. Animal studies indicate that these cytokines can cross the blood-brain barrier. Such crossover could potentially affect the immune system in the brain by inducing gene expression of proinflammatory genes...
February 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28243972/genetic-interaction-of-dgat2-and-faah-in-the-development-of-human-obesity
#19
Tinglu Ning, Yaoyu Zou, Minglan Yang, Qianqian Lu, Maopei Chen, Wen Liu, Shaoqian Zhao, Yingkai Sun, Juan Shi, Qinyun Ma, Jie Hong, Ruixin Liu, Jiqiu Wang, Guang Ning
PURPOSE: DGAT2 is the critical catalyzing enzyme for triglyceride biosynthesis, and excess triglyceride accumulation in fat tissues is a fundamental process for obesity. Mutations in DGAT2 or other genes interacting with DGAT2 associated with adiposity have not been reported in human to date. METHODS: DGAT2 mutation was identified based on our in-home database-exome sequencing 227 young obese subjects (body-mass index (BMI), 35.1-61.7 kg/m(2)) and 219 lean controls (BMI, 17...
February 27, 2017: Endocrine
https://www.readbyqxmd.com/read/28239649/switching-harmful-visceral-fat-to-beneficial-energy-combustion-improves-metabolic-dysfunctions
#20
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh J Samani, Yun Zhang, Yihai Cao
Visceral fat is considered the genuine and harmful white adipose tissue (WAT) that is associated to development of metabolic disorders, cardiovascular disease, and cancer. Here, we present a new concept to turn the harmful visceral fat into a beneficial energy consumption depot, which is beneficial for improvement of metabolic dysfunctions in obese mice. We show that low temperature-dependent browning of visceral fat caused decreased adipose weight, total body weight, and body mass index, despite increased food intake...
February 23, 2017: JCI Insight
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