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Fertility preservation oncology

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https://www.readbyqxmd.com/read/28645304/validation-of-an-automated-technique-for-ovarian-cortex-dissociation-isolation-of-viable-ovarian-cells-and-their-qualification-by-multicolor-flow-cytometry
#1
Tristan Zver, Elodie Mouloungui, Aurélie Berdin, Christophe Roux, Clotilde Amiot
BACKGROUND: Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduction of malignant cells in cases of cancer. It is therefore essential to qualify ovarian tissue before autograft on a functional and oncological point of view...
June 23, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28632245/development-of-an-instrument-to-examine-nursing-attitudes-toward-fertility-preservation-in-oncology
#2
Maria C Grabowski, Deborah A Spitzer, Sonja E Stutzman, DaiWai M Olson
PURPOSE/OBJECTIVES: To develop an instrument to measure staff nurse perceptions of the barriers to and benefits of addressing fertility preservation (FP) with patients newly diagnosed with cancer. 
. DESIGN: A prospective, nonrandomized instrument development approach. 
. SETTING: Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center in Dallas. 
. SAMPLE: 224 RNs who care for patients with cancer...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28609273/knowledge-regarding-fertility-preservation-in-cancer-patients-a-population-based-survey-among-brazilian-people-during-the-pink-october-awareness-event
#3
Mauricio B Chehin, Tatiana Cs Bonetti, Paulo C Serafini, Eduardo LA Motta
OBJECTIVE: The aim of this study was to assess the knowledge about the risk of infertility in cancer patients after treatment, and the options for fertility preservation based on a survey carried out during the 2013 Pink October campaign. METHODS: This survey was carried out during the 2013 Pink October event in the most important public park of São Paulo, Brazil. Approximately 900 people expressed interest in learning about breast cancer prevention and fertility preservation by participating in workshops, and 242 people filled out a questionnaire...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28604126/strategies-for-overcoming-oncological-treatment-related-ovarian-dysfunction-literature-review
#4
Katarzyna Pankiewicz, Grzegorz Szewczyk, Tomasz Mikołaj Maciejewski, Dariusz Szukiewicz
In the majority of developed countries, it is observed that the time for maternity is being postponed to over the 30th and even 40th year of life. A significant number of cancers are diagnosed during reproductive age, often before the first pregnancy. A fertility preservation is an important issue in oncological treatment, where there is a need for balancing between radicality and the preservation of function of reproductive organs. The authors discuss the problem of ovarian dysfunction after oncological treatment and present the possible strategies for saving the reproductive function of ovaries, including both invasive and pharmacological approaches...
June 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28551906/-fertility-preservation-in-young-cancer-patients-can-we-optimize-the-path
#5
REVIEW
Irit Ben-Aharon, Shifra Ash, Avi Ben-Haroush, Gali Perl, Galia Oron, Haim Pinkas, Naphtali Freud, Dragan Kravarusic, Ronit Abir, Onit Sapir, Arnon Wiznitzer, Baruch Brenner, Isaac Yaniv, Salomon Stemmer, Benjamin Fisch
INTRODUCTION: Advances in cancer therapy have improved the long-term survival of cancer patients. Concerns about fertility represent a major issue for young cancer patients. The emergent discipline of oncofertility, an intersection between oncology and fertility, is a new concept that describes an integrated network of clinical resources that focus on fertility preservation from both clinical and research perspectives. Patients and methods: In this article we describe our designated multidisciplinary program for fertility preservation in pediatric and young adult populations...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28550713/state-of-the-art-on-oocyte-cryopreservation-in-female-cancer-patients-a-critical-review-of-the-literature
#6
REVIEW
Claudia Massarotti, Paola Scaruffi, Matteo Lambertini, Valentino Remorgida, Lucia Del Mastro, Paola Anserini
During the last decades, important advances in therapeutic options have led to increased survival rates in cancer patients; however, cancer treatments are associated with several potential adverse effects including infertility in those diagnosed during their reproductive years. A proper discussion about fertility preservation options before the use of therapies with potential gonadotoxicity (i.e. oncofertility counseling) is standard of care and should be offered to all patients of childbearing age. Temporary ovarian suppression with LH-RH analogs, oocyte and embryo cryopreservation are standard strategies for fertility preservation in female cancer patients...
June 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28545332/a-nationwide-uk-survey-of-female-fertility-preservation-prior-to-cancer-treatment
#7
Yazan Abdallah, Jonathan Briggs, Joshua Jones, Gregory Horne, Cheryl Fitzgerald
This survey examined the provision of fertility preservation for female oncology patients prior to cancer treatments, given their well-established gonadotoxic effects. Questionnaires were sent to all assisted conception units in the UK enquiring about the provision of oocyte or embryo cryopreservation, as well as funding for female oncology patients. In addition, data were obtained from the Human Fertilisation and Embryology Authority (HFEA) on the number of cryopreservation cycles in 2013-2014. Of the 60 responding units, 53 (88%) offered fertility preservation...
May 26, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28534015/oncologic-and-obstetric-outcomes-of-conservative-surgery-for-borderline-ovarian-tumors-in-women-of-reproductive-age
#8
Se Yun Lee, Min Chul Choi, Bo Ram Kwon, Sang Geun Jung, Hyun Park, Won Duk Joo, Chan Lee, Je Ho Lee, Joon Mo Lee
OBJECTIVE: To compare the oncologic and obstetric outcomes in reproductive-age females with borderline ovarian tumors (BOTs) treated with cyst enucleation (CE) or unilateral salpingo-oophorectomy (USO). METHODS: The medical records of patients with BOTs treated between 1998 and 2014 were retrospectively reviewed. The recurrence rates in the USO and CE groups were compared, and the postoperative obstetric outcomes were assessed via telephone survey. RESULTS: Eighty-nine patients with BOTs underwent USO, and 19 underwent CE...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28510760/what-factors-hinder-the-decision-making-process-for-women-with-cancer-and-contemplating-fertility-preservation-treatment
#9
Georgina Jones, Jane Hughes, Neda Mahmoodi, Emily Smith, Jonathan Skull, William Ledger
BACKGROUND: Although fertility preservation (FP) treatment options have increased, the existing evidence suggests that many women with cancer do not feel well supported in making these decisions, but find them stressful and complex and fail to take up fertility care at this crucial time. Whilst existing reviews have all made important contributions to our understanding of the FP decision-making process, none of them examine solely and specifically these processes for women of reproductive age with a diagnosis of any cancer, leaving a gap in the knowledge base...
May 16, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28503722/fertility-preservation-with-ovarian-stimulation-and-time-to-treatment-in-women-with-stage-ii-iii-breast-cancer-receiving-neoadjuvant-therapy
#10
A Jo Chien, Julia Chambers, Fiona Mcauley, Tessa Kaplan, Joseph Letourneau, Jimmy Hwang, Mi-Ok Kim, Michelle E Melisko, Hope S Rugo, Laura J Esserman, Mitchell P Rosen
PURPOSE: To determine whether fertility preservation with ovarian stimulation (OS) results in treatment delay in breast cancer (BC) patients receiving neoadjuvant therapy (NAT). METHODS: This is a retrospective study of women screened for the prospective neoadjuvant ISPY2 trial at the University of California San Francisco. All patients were <43, had stage II-III BC, and received neoadjuvant therapy. Time to initiation of NAT was compared between women who underwent OS (STIM) and women who did not (control)...
May 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28490359/cryopreservation-of-reproductive-material-before-cancer-treatment-a-qualitative-study-of-health-care-professionals-views-about-ways-to-enhance-clinical-care
#11
Karin Hammarberg, Maggie Kirkman, Catharyn Stern, Robert I McLachlan, Debra Gook, Luk Rombauts, Beverley Vollenhoven, Jane R W Fisher
BACKGROUND: Cancer treatment can diminish fertility in women and men. The need for fertility preservation is growing as increasing numbers of people survive cancer. Cryostorage of reproductive material to preserve potential for conception for cancer survivors has moved from being experimental to being a part of clinical management of women and men who are diagnosed with cancer in their reproductive years. There is little existing evidence about how fertility preservation services can be enhanced to meet the complex needs of patients who are diagnosed with cancer in their reproductive years...
May 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28481445/optimising-fertility-outcomes-for-women-with-early-stage-cervical-cancer-when-less-is-more
#12
E Tingi, E J Crosbie, G Owens
No abstract text is available yet for this article.
May 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28468536/-oncofertility-and-therapeutic-modalities-survey-of-literature
#13
Tamás Sápy, Róbert Póka
Surgical and radiological treatment as well as chemotherapy and biological therapy may have harmful effects on young patients' future fertility. Increasingly greater emphasis has been put on ensuring these patients' long-term quality of life, therefore, in addition to survival, preserving their prospective fertility is also among our aims. The term 'oncofertility' has been compounded from two expressions, 'oncology' and attempts to 'fertility preservation'. In gynecology, fertility preservation involves not only special surgical procedures but also interventions intended to preserve gametes, reproductive organs and embryos...
May 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28435402/synchronous-bilateral-testis-cancer-clinical-and-oncological-management
#14
Davide Campobasso, Stefania Ferretti, Antonio Frattini
Synchronous bilateral testis cancer (SBTC) is a rare event. It represents only 0.5-1% of all new cases of testicular cancer. Patients with this disease require careful management for psychological, oncological, and medical problems. We performed a PubMed search for all series that reported SBTC. We considered only articles in English, reporting on more than three cases. We also performed an analysis of the reported evidence regarding testosterone replacement and surgical treatment. We found 10 studies satisfying inclusion criteria for a total of 73 patients...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28423955/double-ovarian-stimulation-duostim-protocol-for-fertility-preservation-in-female-oncology-patients
#15
Nikolaos Tsampras, Della Gould, Cheryl T Fitzgerald
This article describes a revised ovarian stimulation protocol (DuoStim) for fertility preservation in female oncology patients which aims to maximise the number of gametes obtained with subsequent improvement in cumulative birth rate, without delaying cancer treatment. Ten patients diagnosed with malignancy between September 2014 and October 2015 were included. The patients were treated with the DuoStim protocol, undergoing two consecutive ovarian stimulation cycles and two oocyte retrievals. The primary outcome was the number of oocytes collected and vitrified during each oocyte retrieval and in total...
February 9, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28420497/radical-trachelectomy-for-early-stage-cervical-cancer-a-case-series-and-literature-review
#16
Chin-Jui Wu, Wen-Chun Chang, Chi-Hau Chen, Chi-An Chen, Su-Cheng Huang, Bor-Ching Sheu
OBJECTIVE: Radical trachelectomy (RT) is an alternative treatment for preserving fertility in patients with cervical cancer. Because women with operable cervical cancer opting for fertility preservation are scarce, few cases have been reported in Taiwan. Here we report our cases series. MATERIALS AND METHODS: We retrospectively evaluated seven patients who underwent vaginal RT and three patients who underwent abdominal RT in a single medical institute for a median follow-up period of 5 years...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28418849/oncologic-and-obstetrical-outcomes-with-fertility-sparing-treatment-of-cervical-cancer-a-systematic-review-and-meta-analysis
#17
REVIEW
Qing Zhang, Wenhui Li, Margaux J Kanis, Gonghua Qi, Minghao Li, Xingsheng Yang, Beihua Kong
OBJECTIVE: The objectives of this study were to evaluate the rates of recurrence, survival and pregnancy, and characterize pregnancy outcomes of early-stage cervical cancer(eCC) treated with fertility-sparing methods such as cervical conization (CON) and radical trachelectomy(RT) with or without pelvic lymphadenectomy. STUDY DESIGN: This was a meta-analysis of observational studies analyzed by a random-effects model and a meta-regression to assess heterogeneity...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28398024/gonadotropin-releasing-hormone-analogues-for-the-prevention-of-chemotherapy-induced-premature-ovarian-failure-in-breast-cancer-patients
#18
Benedetta Conte, Lucia Del Mastro
Since the survival of patients with cancer has significantly improved, chemotherapy-related premature ovarian failure (POF) in young cancer survivors has become a major issue in oncology. POF is associated with several health-related negative consequences, including menopausal symptoms, increased risk of cardiovascular diseases, osteoporosis, sexual disfunction, and infertility1-5. According to the major international guidelines, embryo/oocyte cryopreservation are the standard procedures for fertility preservation in young cancer women6,7...
April 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28346240/combined-oral-medroxyprogesterone-levonorgestrel-intrauterine-system-treatment-for-women-with-grade-2-stage-ia-endometrial-cancer
#19
Ji Young Hwang, Da Hee Kim, Hyo Sook Bae, Mi-La Kim, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Eunah Shin, Mi Kyoung Kim
OBJECTIVE: The aim of this study was to evaluate the oncologic and pregnancy outcomes of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment in young women with grade 2-differentiated stage IA endometrial adenocarcinoma who wish to preserve fertility. METHODS: We retrospectively reviewed the medical records of patients with grade 2 stage IA endometrial adenocarcinoma who had received fertility-sparing treatment at CHA Gangnam Medical Center between 2011 and 2015...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28333228/efficacy-of-ovarian-tissue-cryopreservation-for-fertility-preservation-lessons-learned-from-545-cases
#20
P Jadoul, A Guilmain, J Squifflet, M Luyckx, R Votino, C Wyns, M M Dolmans
STUDY QUESTION: How effective is ovarian tissue cryopreservation (OTC)? SUMMARY ANSWER: In our cohort of patients who underwent OTC, premature ovarian failure (POF) rates, return rates and pregnancy rates after autotransplantation were 31.5, 4.4 and 33%, respectively. WHAT IS KNOWN ALREADY: OTC for fertility purposes has been performed for >20 years now. With over 86 live births reported worldwide and success rates of ~30% after autotransplantation of frozen-thawed ovarian cortex, the procedure should no longer be considered experimental...
May 1, 2017: Human Reproduction
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