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Fertility preservation oncology

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https://www.readbyqxmd.com/read/28073207/intraoperative-ultrasound-guided-enucleation-of-testicular-nodule
#1
Riccardo Boschian, Giovanni Liguori, Stefano Bucci, Michele Bertolotto, Carlo Trombetta
OBJECTIVE: We report a case of enucleation of a non-palpable right testicular lesion found incidentally at testicular ultrasonography during investigations in a patient with azoospermia. MATERIALS AND METHODS: In 2011 bilateral hypoechoic nonpalpable testicular lesions (5 mm and 3 mm to the right, 3 mm to the left) were found in a 28 years old patient, during diagnostic investigations for azoospermia. In March 2016, ultrasonography showed that the diameter of the right major nodule had grown to 12 mm, characterized by increased vascularization and increased texture...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28070774/restoring-fertility-with-cryopreserved-prepubertal-testicular-tissue-perspectives-with-hydrogel-encapsulation-nanotechnology-and-bioengineered-scaffolds
#2
Maxime Vermeulen, Jonathan Poels, Francesca de Michele, Anne des Rieux, Christine Wyns
New and improved oncological therapies are now able to cure more than 80% of cancer-affected children in Europe. However, such treatments are gonadotoxic and result in fertility issues, especially in boys who are not able to provide a sperm sample before starting chemo/radiotherapy because of their prepubertal state. For these boys, cryopreservation of immature testicular tissue (ITT) is the only available option, aiming to preserve spermatogonial stem cells (SSCs). Both slow-freezing and vitrification have been investigated to this end and are now applied in a clinical setting for SSC cryopreservation...
January 9, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28062551/new-stimulation-regimens-endogenous-and-exogenous-progesterone-use-to-block-the-lh-surge-during-ovarian-stimulation-for-ivf
#3
REVIEW
Nathalie Massin
BACKGROUND: The advent of embryo and oocyte vitrification today gives reproductive specialists an opportunity to consider new strategies for improving the practice and results of IVF attempts. As the freezing of entire cohorts does not compromise, and may even improve, the results of IVF attempts, it is possible to break away from the standard sequence of stimulation-retrieval-transfer. The constraints associated with ovarian stimulation in relation to the potential harmful effects of the hormonal environment on endometrial receptivity can be avoided...
January 5, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28050959/fertility-preservation-in-endometrial-cancer-is-it-safe-review-of-the-literature
#4
REVIEW
Márcia Mendonça Carneiro, Rívia Mara Lamaita, Márcia Cristina França Ferreira, Agnaldo Lopes Silva-Filho
Almost 5% of women with endometrial cancer are under age 40, and they often have well-differentiated endometrioid estrogen-dependent tumors. Cancer survival rates have improved over the last decades so strategies to avoid or reduce the reproductive damage caused by oncologic treatment are needed. We reviewed the published literature to find evidence to answer the following questions: How should we manage women in reproductive age with endometrial cancer? How safe is fertility preservation in endometrial cancer? Can pregnancy influence endometrial cancer recurrence? What are the fertility sparing options available? Progestins may be prescribed after careful evaluation and counseling...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28026055/fertility-preservation-counselling-in-dutch-oncology-practice-are-nurses-ready-to-assist-physicians
#5
E M Krouwel, M P J Nicolai, A Q M J van Steijn-van Tol, H Putter, S Osanto, R C M Pelger, H W Elzevier
Cancer and its treatments may result in impaired fertility, which could cause long-term distress to cancer survivors. For eligible patients, fertility preservation (FP) is available to secure future reproductive potential. Many physicians, however, feel inhibited about discussing FP. Oncology nurses may serve as an initiator for discussing the subject and provide additional support. Our aim was to investigate their knowledge about FP, the way they apply this, and possible barriers to discussing FP with patients of reproductive age...
December 27, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28012689/oncofertility-for-women-with-gynecologic-malignancies
#6
REVIEW
Jessica L Chan, Erica T Wang
The emerging field of oncofertility addresses fertility and the reproductive health needs for cancer patients, a key topic in cancer survivorship. Given that the standard treatment for gynecologic malignancies involves removal of reproductive organs, pelvic radiation, or chemotherapy, the effect of such treatment on fertility and options for fertility preservation are even more relevant than for other malignancies. In young women with new diagnoses of cervical, endometrial, or ovarian cancers, viable strategies for fertility preservation without compromising oncological outcome exist and should be considered...
December 21, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27998702/provider-influences-on-sperm-banking-outcomes-among-adolescent-males-newly-diagnosed-with-cancer
#7
James L Klosky, L Elizabeth Anderson, Kathryn M Russell, Lu Huang, Hui Zhang, Leslie R Schover, Jessica L Simmons, William H Kutteh
PURPOSE: The purpose of this study was to examine provider communication and sociodemographic factors which associate with sperm banking outcomes in at-risk adolescents newly diagnosed with cancer. METHODS: A prospective single-group quasi-experimental study design was used to test the contributions of provider factors on sperm banking outcomes. Medical providers (N = 52, 86.5% oncologists) and 99 of their at-risk adolescent patients from eight leading pediatric oncology centers in North America completed questionnaires querying provider factors and patient sperm banking outcomes...
December 17, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27955736/fertility-considerations-and-the-pediatric-oncology-patient
#8
Raffoul Lara, Capito Carmen, Sarnacki Sabine
Recent years have witnessed marked improvement in cytotoxic treatments with a parallel increase in patient survival. Despite efforts done to minimize long-term side effects of these treatment regimens, it is estimated that 40% of survivors of pediatric cancer will suffer from those. Some will be mild whereas others such as impaired fertility will be a heavy load on parents׳ expectations and patient׳s quality of life. Gonadal damage and severe loss of function is not a rare condition among children cured for cancer...
October 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27940355/temporary-ovarian-suppression-during-chemotherapy-to-preserve-ovarian-function-and-fertility-in-breast-cancer-patients-a-grade-approach-for-evidence-evaluation-and-recommendations-by-the-italian-association-of-medical-oncology
#9
REVIEW
Matteo Lambertini, Michela Cinquini, Ivan Moschetti, Fedro A Peccatori, Paola Anserini, Mario Valenzano Menada, Maurizio Tomirotti, Lucia Del Mastro
The development of premature ovarian failure and subsequent infertility are possible consequences of chemotherapy use in pre-menopausal women with early-stage breast cancer. Among the available strategies for fertility preservation, pharmacological protection of the ovaries using luteinising hormone-releasing hormone analogues (LHRHa) during chemotherapy has the potential to restore ovarian function and fertility after anticancer treatments; however, the possible efficacy and clinical application of this strategy has been highly debated in the last years...
January 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27906588/fertility-preservation-in-pediatric-and-adolescent-oncology-patients-the-decision-making-process-of-parents
#10
Nancy Li, Yasmin Jayasinghe, Matthew A Kemertzis, Paddy Moore, Michelle Peate
PURPOSE: Decisions surrounding fertility preservation (FP) in children, adolescents, and adults can be difficult due to the distress of a cancer diagnosis, time constraints for decision-making, and lack of efficacy data. This review examines the decision-making process of oncology patients and their parents (if patients are in the pediatric or adolescent population) to better understand experiences of decisional conflict and regret. METHODS: Two electronic databases, Embase and Pubmed, were searched using the terms (Decision-making OR Conflict (Psychology) OR Decision regret) AND (Freezing OR Oocyte OR Ovarian tissue OR Semen preservation OR Fertility preservation OR Cryopreservation) AND (Neoplasms OR Cancer OR Chemotherapy OR Drug therapy OR Radiotherapy)...
December 1, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27887012/epididymal-papillary-cystadenocarcinoma-metastasising-to-the-testis-in-a-patient-with-infertility-managed-with-onco-microtese
#11
Nisha Pindoria, Yurina Miki, Andrea Tay, Ashish Chandra, Christopher Anderson, Evangelos Zacharakis, Majed Shabbir
Papillary cystadenomas of the epididymis are known to occur in association with Von Hippel-Lindau (VHL) disease. The development of a papillary cystadenocarcinoma, its malignant counterpart, is rare with only a few sporadic cases reported in the literature. Metastatic deposits are exceedingly uncommon; in fact, only a single case report has documented metastases to the paraureteral region, but metastases to the testis have never been reported. A 43-year-old gentleman with VHL disease presented with non-obstructive azoospermia, a right epididymal mass, and an atrophic surgically corrected undescended left testis...
November 24, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27817861/-fertility-preservation-in-adolescents-and-young-adults-with-cancer
#12
REVIEW
Christine Rousset-Jablonski, Florian Chevillon, Nathalie Dhedin, Catherine Poirot
Fertility impairment due to treatments is a major concern for patients who have survived cancer in adolescence or as a young adult. The impact of cancer treatments on fertility depends on the age at treatments, types and cumulative doses of chemotherapy, radiation doses to organs at risk, and on surgeries conducted. Fertility preservation strategies have been developed for many years, and recently diversified thanks to advances in reproductive biology. In female adolescents and young adults, ovarian stimulation followed by oocyte (or embryo) vitrification, ovarian tissue cryopreservation, and sometimes oocyte vitrification after in vitro maturation are options that can be discussed...
December 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27804040/oncologic-and-obstetric-outcomes-and-complications-during-pregnancy-after-fertility-sparing-abdominal-trachelectomy-for-cervical-cancer-a-retrospective-review
#13
Kaoru Okugawa, Hiroaki Kobayashi, Kenzo Sonoda, Eisuke Kaneki, Yoshiaki Kawano, Nobuhiro Hidaka, Katsuko Egashira, Yasuyuki Fujita, Hideaki Yahata, Kiyoko Kato
BACKGROUND: Trachelectomy was developed as a fertility-sparing surgery for early-stage cervical cancer in patients of childbearing age. The purpose of this study is to evaluate oncologic and obstetric outcomes and complications after abdominal trachelectomy. METHODS: We began to perform abdominal trachelectomy in 2005. Our institutional review board approved this clinical study, and fully informed consent was obtained from each patient. The medical records of patients who underwent trachelectomy were retrospectively reviewed...
November 1, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27795832/fertility-sparing-management-in-cervical-cancer-balancing-oncologic-outcomes-with-reproductive-success
#14
REVIEW
Karla Willows, Genevieve Lennox, Allan Covens
BACKGROUND: Cervical cancer is the fourth most common cancer among women worldwide, many of who are still within their reproductive lifespan. Advances in screening and treatment have increased the 5-year survival for early stage disease to over 90 % in developed countries. The focus is now shifting to reducing morbidity and improving fertility outcomes for cervical cancer patients. Radical trachelectomy with lymph node assessment became the standard of care for selected women with lesions <2 cm who desire fertility preservation...
2016: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/27785439/malignancy-in-disorders-of-sex-development
#15
REVIEW
Martin Kathrins, Thomas F Kolon
Disorders of sex development (DSD) represent a spectrum of conditions in which chromosomal, gonadal, or anatomic sex are atypical and affect 1 in 4,500-5,000 live births. The diagnosis of DSD raises concerns of tumor risk and treatment as well as future fertility preservation. We review the current understanding of the types of gonadal tumors that arise in DSD patients as well as possible markers and treatment. The goal is to inform the members of the DSD team (urologist, endocrinologist, geneticist, psychologist) of the latest findings regarding malignancy in DSD...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27761026/surgical-aspects-of-ovarian-tissue-removal-and-ovarian-tissue-transplantation-for-fertility-preservation
#16
REVIEW
M W Beckmann, R Dittrich, S Findeklee, L Lotz
Introduction: The removal of ovarian tissue prior to starting oncologic treatment and the subsequent transplantation of this tissue after completing therapy have become increasingly important surgical fertility-preserving techniques. The aim of this review was to investigate the different surgical techniques used for this method reported in the literature to date and to discuss the advantages and disadvantages of the respective techniques. Review: A search was done in MEDLINE using a defined algorithm to find studies published between January 2004 and December 2015...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27734578/highly-sensitive-assessment-of-neuroblastoma-minimal-residual-disease-in-ovarian-tissue-using-rt-qpcr-a-strategy-for-improving-the-safety-of-fertility-restoration
#17
Victoria Grèze, Florence Brugnon, Fanny Chambon, Pascale Halle, Michel Canis, Clotilde Amiot, Anne-Sophie Grémeau, Bruno Pereira, Yania Yáñez Peralta, Andrei Tchirkov, Justyna Kanold
BACKGROUND: Ovarian tissue cryopreservation (OTC) is the only option available to preserve fertility in prepubertal females with neuroblastoma (NB), a childhood solid tumor that can spread to the ovaries, with a risk of reintroducing malignant cells after an ovarian graft. PROCEDURE: We set out to determine whether the analysis of TH (tyrosine hydroxylase), PHOX2B (paired-like homeobox 2b), and DCX (doublecortin) transcripts using quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) could be used to detect NB contamination in ovarian tissue...
October 12, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27699036/neoadjuvant-chemotherapy-followed-by-conization-to-spare-fertility-in-cases-of-locally-advanced-cervical-cancer-a-case-report-and-review-of-the-literature
#18
Yanling Feng, Tiefeng Cao, Yin Wang, He Huang, Yujie Xie, Jihong Liu
The average age when cervical cancer is diagnosed is decreasing, resulting in a larger proportion of patients seeking fertility preservation. Therefore, a less radical approach that aims to preserve the potential for fertility during the treatment of cervical carcinoma is crucial. The present study reported a case of a patient with stage IB2 cervical cancer who exhibited pathological complete regression to neoadjuvant chemotherapy (NACT). This patient underwent deep cervical conization and laparoscopic lymphadenectomy to preserve her fertility...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27685935/oocyte-cryopreservation-for-fertility-preservation-in-women-with-cancer
#19
Javier Domingo, Juan A Garcia-Velasco
PURPOSE OF REVIEW: It is necessary to clarify the fertility preservation-related points of concern that often frighten patients or physicians when it comes to deciding about oocyte cryopreservation for fertility preservation, which are often perceived as procedure limitations, are sometimes real and often theoretical and may make the prognosis worse. RECENT FINDINGS: Letrozole added to gonadotrophins for controlled ovarian stimulation is safe when applied to hormone-sensitive cancer patients as it avoids associated high estradiol levels...
December 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27671919/improving-access-to-standardized-fertility-preservation-information-for-older-adolescents-and-young-adults-with-cancer-using-a-user-centered-approach-with-young-adult-patients-survivors-and-partners-to-refine-fertility-knowledge-transfer
#20
Seline Tam, Natasha Puri, Derek Stephens, Laura Mitchell, Meredith Giuliani, Janet Papadakos, Abha A Gupta
Adolescent and young adult (AYA) cancer patients under 40 should be made aware of their fertility risks and preservation options throughout their care. However, discussions on fertility preservation (FP) do not routinely occur. With a dearth of FP resources, oncology providers may lack knowledge around FP. Thus, informational needs can be unmet, leading to anxiety and distress in patients. Provision of pertinent and timely information can help patients cope better with their diagnosis. FP pamphlets were developed for men and women with cancer...
September 27, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
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