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Fertility preservation oncology

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https://www.readbyqxmd.com/read/29221705/female-fertility-preservation-in-the-pediatric-and-adolescent-cancer-patient-population
#1
REVIEW
Gabriela N Algarroba, Joseph S Sanfilippo, Hanna Valli-Pulaski
The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population...
October 26, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29221696/fertility-preservation-in-pediatric-subspecialties-a-pilot-needs-assessment-beyond-oncology
#2
Branavan Vakeesan, Danielle R Weidman, Anne Marie Maloney, Lisa Allen, Armando J Lorenzo, Abha A Gupta
Physicians from 6 non-oncology pediatric subspecialties were surveyed about fertility preservation (FP) to assess education/service needs. Almost all (96%; 25 of 26) reported having patients at risk of infertility; however, only 58% (15 of 26) had discussed FP with patients' families. Most subspecialists (92%; 23 of 25) would like access to an FP program. Our data support exploring the expansion of FP programs beyond oncology.
December 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29221621/-fertility-preservation-in-oncology
#3
REVIEW
Laure Chaput, Anne-Sophie Grémeau, Solène Vorilhon, Hanae Pons, Cécile Chabrot, Victoria Grèze, Jean-Luc Pouly, Florence Brugnon
Since the improvement of cancer diagnosis and treatment, survival rates of these patients increase. Gonadal damages are frequent consequences of cancer treatments with different evidence of impaired fertility. In this context, fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatments. Different preservation approaches may be proposed depending on patient age, sex, cancer type and type of treatment. The indications of fertility preservation depend on sexual maturity...
December 5, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29203995/management-of-borderline-ovarian-tumors-still-a-gray-zone
#4
Nidhi Nayyar, Prerna Lakhwani, Ashish Goel, Pankaj Kr Pande, Kapil Kumar
Borderline ovarian tumors (BOTs) are a heterogeneous group of non-invasive epithelial ovarian tumors that occur at a younger age, present in early stage, frequently associated with infertility but are easily curable. Although they may have symptomatic long-term recurrences, they have an excellent prognosis in spite of peritoneal spread. Among the epithelial tumors of the ovary, BOTs fall in the spectrum lying between cystadenomas (benign) and cystadenocarcinomas (malignant). Their oncological behavior is more aggressive than benign ovarian tumors but relatively less than that of malignant ovarian tumors...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29198423/fertility-protection-complications-of-surgery-and-results-of-removal-and-transplantation-of-ovarian-tissue
#5
Matthias W Beckmann, Ralf Dittrich, Laura Lotz, Karin van der Ven, Hans H van der Ven, Jana Liebenthron, Matthias Korell, Torsten Frambach, Marc Sütterlin, Roxana Schwab, Stefan Seitz, Andreas Müller, Michael von Wolff, Felix Häberlin, Melanie Henes, Katharina Winkler-Crepaz, Jan S Krüssel, Ariane Germeyer, Bettina Toth
Fertility-preserving measures are becoming important for patients receiving oncological treatment. One method involves cryopreservation of ovarian tissue and transplanting it when treatment is completed. We report complications resulting from surgical and fertility medicine, and the results of procedures for the removal and transplantation of ovarian tissue carried out within the FertiProtekt network. A survey using a structured questionnaire was conducted among the FertiProtekt network centres between November 2015 and June 2016...
November 9, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29184796/oncofertility-in-sarcoma-patients
#6
REVIEW
Diana M Lopategui, Raphael Yechieli, Ranjith Ramasamy
Treatment for sarcoma can significantly decrease fertility, both due to the irradiation of gonads, and the impact of chemotherapy on gametogenesis. Infertility in cancer survivors causes significant regret and decreased quality of life in their adulthood. As this cancer mainly affects children and young adults, fertility preservation is an essential part of survivorship care, however it remains one of the least implemented services in adolescent and young adult cancer patients. Success of fertility preservation is highly dependent on the referral prior to oncologic treatment...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29168588/ovarian-response-to-controlled-ovarian-stimulation-for-fertility-preservation-before-oncology-treatment-a-retrospective-cohort-of-157-patients
#7
Nikolaos Tsampras, Stephen A Roberts, Della Gould, Cheryl T Fitzgerald
This is a retrospective cohort study aiming to examine the response of oncology patients undergoing controlled ovarian stimulation (COS) for fertility preservation and to review the incidence of short-term complications. The study group consisted by all oncology patients undergoing ovarian stimulation for fertility preservation (n = 157) between April 2009 and April 2016. Patients undergoing COS for IVF/ICSI for male factor only infertility in the same time period (n = 2,128) provided a comparator group...
November 23, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29149096/-fertility-preservation-in-the-oncology-patient
#8
REVIEW
Anibal Scarella Chamy, César Díaz-García, Sonia Herraiz, Jhenifer Kliemchen Rodrigues
In recent years, medical advances have substantially improved survival of cancer patients, generating growing concern about the quality of life of the survivors. Increased attention has been paid to reproductive problems after oncological treatments. International guidelines on fertility preservation in cancer patients require that healthcare teams discuss, as early as possible, the impact of cancer treatments on fertility and encourage access to fertility preservation techniques. The development of these techniques in women is a recent effort and many patients and health care providers are not familiar with their rapid expansion...
November 16, 2017: Medwave
https://www.readbyqxmd.com/read/29123075/evaluation-of-the-awareness-of-attitude-to-and-knowledge-about-fertility-preservation-in-cancer-patients-among-clinical-practitioners-in-hong-kong
#9
J Pw Chung, T Th Lao, T C Li
INTRODUCTION: Individuals can be exposed to gonadotoxic agents in the course of treatment for cancers and other medical conditions. Fertility preservation refers to strategies that aim to preserve fertility by protecting it against the damage inflicted by gonadotoxic treatment. Many young patients are prescribed gonadotoxic treatment without prior counselling. This study aimed to study the awareness of, attitude to, and knowledge about fertility preservation among clinicians in Hong Kong...
November 10, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29119739/fertility-outcomes-in-infertile-women-with-complex-hyperplasia-or-complex-atypical-hyperplasia-who-received-progestin-therapy-and-in-vitro-fertilization
#10
Miao Li, Jia-Lun Song, Ying Zhao, She-Ling Wu, Hong-Bin Liu, Rong Tang, Lei Yan
This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29117320/update-on-fertility-preservation-from-the-barcelona-international-society-for-fertility-preservation-eshre-asrm-2015-expert-meeting-indications-results-and-future-perspectives
#11
Francisca Martinez
STUDY QUESTION: What progress has been made in fertility preservation (FP) over the last decade? SUMMARY ANSWER: FP techniques have been widely adopted over the last decade and therefore the establishment of international registries on their short- and long-term outcomes is strongly recommended. WHAT IS KNOWN ALREADY: FP is a fundamental issue for both males and females whose future fertility may be compromised. Reproductive capacity may be seriously affected by age, different medical conditions and also by treatments, especially those with gonadal toxicity...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29069949/fertility-sparing-surgery-in-epithelial-ovarian-cancer-in-italy-perceptions-practice-and-main-issues
#12
Alice Bergamini, Micaela Petrone, Emanuela Rabaiotti, Francesca Pella, Raffaella Cioffi, Elena Giulia Rossi, Valentina Di Mattei, Massimo Candiani, Giorgia Mangili
About 2.7% of patients epithelial ovarian cancers (EOC) are younger than 40 and present with stage I disease. For this subset of women, the issue of fertility sparing surgery (FSS) has become critical. The aim of this survey was to investigate the management of EOC patients desiring to preserve fertility in Italy. A questionnaire consisting of 30 items was developed to evaluate: patient-selection criteria, rate of FSS, patient's counseling- and pregnancy-timing, fertility preservation, obstetrics, and oncologic outcomes...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29056644/devastation-and-hope-stories-of-fertility-in-oncology
#13
Bryan A Sisk
Having children is a deeply held desire for many people. After a cancer diagnosis, fertility is often threatened by cancer treatments. The choice to pursue fertility preservation often necessitates a delay in starting cancer treatment which may negatively impact the patient. Fertility decisions are laden with heavy emotional burden and multiple ethical challenges. The narratives in this symposium provide rich emotional context, including allusions to failure, loss, guilt, fear, anger, hope, and acceptance. Given the important role of emotion in moral reasoning, exploration of these emotions supports further discussion of ethical challenges...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29056630/cancer-and-fertility
#14
Ana S Iltis
This symposium includes 12 personal narratives from individuals who have faced a cancer diagnosis-either their own or their child's-where the disease itself, or their treatment, threatened future fertility. Three additional stories are available in the online supplement. Three commentaries on these narratives are written by an expert in oncofertility, a healthcare ethicist, and a pediatrician completing a fellowship in hematology/oncology. The observations and insights these authors share underscore the importance of addressing fertility loss and preservation early in the cancer journey...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29040511/development-of-the-testis-in-pre-pubertal-boys-with-cancer-after-biopsy-for-fertility-preservation
#15
M Uijldert, A Meißner, A A de Melker, A M M van Pelt, M D van de Wetering, R R van Rijn, M van Wely, F van der Veen, S Repping
STUDY QUESTION: Is testicular growth affected by a testicular biopsy intended for fertility preservation in pre-pubertal boys with cancer? SUMMARY ANSWER: Testicular growth of the biopsied testis is not impeded in comparison to the non-biopsied contralateral testis up until 1 year after surgery. WHAT IS KNOWN ALREADY: Fertility preservation in pre-pubertal boys by means of testicular biopsy has been conducted for more than 15 years. Although immediate adverse effects of testicular biopsy are rare (1%), no data exist on the effect of biopsy on testicular growth...
October 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29032255/single-incision-laparoscopic-surgery-sils-for-ovarian-tissue-cryopreservation
#16
Gilad Karavani, Natali Schachter-Safrai, Henry H Chill, Talya Mordechai Daniel, Dvora Bauman, Ariel Revel
STUDY OBJECTIVE: To present single-incision laparoscopic surgery (SILS) as an alternative to standard multi-port laparoscopic surgery (MPLS) for ovarian tissue cryopreservation (OTC). DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Tertiary medical center. PATIENTS: Two hundred thirty-one patients referred for oncological fertility preservation. INTERVENTION: Non-inferiority comparison of SILS to MPLS for ovarian cryopreservation for future transplantation...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28986185/fertility-sparing-management-using-progestin-for-young-women-with-endometrial-cancer-from-a-population-based-study
#17
Soyoun Rachel Kim, Carlijn van der Zanden, Habibe Ikiz, Boris Kuzelijevic, Jon Havelock, Janice S Kwon
OBJECTIVE: For young women with complex atypical endometrial hyperplasia (CAH) and endometrial cancer (EC) who choose to preserve fertility, progestin therapy is the mainstay of treatment. The objective of this study was to evaluate oncologic and reproductive outcomes associated with progestin therapy among these women from a population-based cancer registry. METHODS: This was a retrospective population-based cohort study of women under age 45 in British Columbia from 2003 to 2015 with CAH or grade I endometrioid EC who used progestins as initial management...
October 3, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28976795/prevalence-and-predictors-of-sperm-banking-in-adolescents-newly-diagnosed-with-cancer-examination-of-adolescent-parent-and-provider-factors-influencing-fertility-preservation-outcomes
#18
James L Klosky, Fang Wang, Kathryn M Russell, Hui Zhang, Jessica S Flynn, Lu Huang, Karen Wasilewski-Masker, Wendy Landier, Marcia Leonard, Karen H Albritton, Abha A Gupta, Jacqueline Casillas, Paul Colte, William H Kutteh, Leslie R Schover
Purpose To estimate the prevalence of sperm banking among adolescent males newly diagnosed with cancer and to identify factors associated with banking outcomes. Patients and Methods A prospective, single-group, observational study design was used to test the contribution of sociodemographic, medical, psychological/health belief, communication, and developmental factors to fertility preservation outcomes. At-risk adolescent males (N = 146; age 13.00 to 21.99 years; Tanner stage ≥ 3), their parents, and medical providers from eight leading pediatric oncology centers across the United States and Canada completed self-report questionnaires within 1 week of treatment initiation...
October 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28938748/random-start-ovarian-stimulation-for-fertility-preservation-appears-unlikely-to-delay-initiation-of-neoadjuvant-chemotherapy-for-breast-cancer
#19
Joseph M Letourneau, Nikita Sinha, Kaitlyn Wald, Eve Harris, Molly Quinn, Tal Imbar, Evelyn Mok-Lin, A Jo Chien, Mitchell Rosen
STUDY QUESTION: Is random start ovarian stimulation associated with delays in initiation of neoadjuvant chemotherapy for breast cancer? SUMMARY ANSWER: Among women who complete fertility preservation (FP) consultation, random start ovarian stimulation is unlikely to delay time to initiation of neoadjuvant chemotherapy start. WHAT IS KNOWN ALREADY: Neoadjuvant chemotherapy is now a widely accepted treatment modality for operable breast cancer and random start ovarian stimulation is an increasingly-utilized modality for FP...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28925939/process-and-pitfalls-of-sperm-cryopreservation
#20
REVIEW
Hamoun Rozati, Thomas Handley, Channa Jayasena
Sperm cryopreservation has been utilized routinely for over 40 years to preserve fertility in men undergoing cancer therapy and allow conception for infertile couples. This article provides a concise and up-to-date review of the literature and covers the latest advances in sperm cryopreservation and its array of clinical indications. Over recent years, the scope of clinical indications used for sperm cryopreservation has expanded widely. Consequently, more patient groups are eligible for sperm freezing, requiring specialist resources and higher running costs...
September 19, 2017: Journal of Clinical Medicine
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