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Fertility preservation oncology

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https://www.readbyqxmd.com/read/29681013/the-effects-of-an-educational-program-for-non-physician-health-care-providers-regarding-fertility-preservation
#1
Emi Takeuchi, Masashi Kato, Kayoko Miyata, Nao Suzuki, Chikako Shimizu, Hiroshi Okada, Naoko Matsunaga, Mariko Shimizu, Natsuko Moroi, Daisuke Fujisawa, Masaru Mimura, Yoko Miyoshi
PURPOSE: The American Society of Clinical Oncology (ASCO) Clinical Practice guidelines recommend that physicians, nurses, social workers, and other health care providers should be prepared to discuss the risk of infertility with patients. We conducted an educational program for non-physician health care providers regarding fertility preservation and evaluated the effects of the educational program. METHODS: The 4-h educational program consisted of lectures about infertility as a potential risk of cancer treatment, fertility preservation, and psychosocial support...
April 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29620987/oocyte-freezing-reproductive-panacea-or-false-hope-of-family
#2
Susie Jacob, Adam Balen
Advanced technology now allows young women to freeze and store oocytes with a realistic chance of future pregnancy. Vitrification has revolutionized oocyte preservation, with comparable pregnancy rates to fresh oocyte use. Traditionally used for women who were about to undergo sterilizing oncology treatment, now the opportunity has been extended for 'social freezing'. A steady rise in all women accessing freezing continues. Despite this, there is a lack of understanding of natural fertility and the impact of age on pregnancy outcomes...
April 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29607231/a-rare-case-report-a-malignant-histiocytic-tumor-in-the-form-of-ovarian-mass
#3
Emsal Pinar Topdagi Yilmaz, Yakup Kumtepe, Yunus Emre Topdagi, Seray Kaya Topdagi
Histiocytic cell malignancies are very rare. Hence, the information about this disease in hematology is limited. In this case report, we present a case of malignant histiocytic tumor affecting the ovary of a 40-year-old virgin female. Primary ovarian malignancy was not considered for the patient who was approached as if she had ovarian malignancy, since there was an indication of a mass in the ovary. Therefore, an aggressive surgery was not performed. Since our patient was in the reproductive age, fertility-preserving surgery was performed...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29582194/clinical-practice-guidelines-for-fertility-preservation-in-pediatric-adolescent-and-young-adults-with-cancer
#4
REVIEW
Nao Suzuki
In recent years, more cancer patients are achieving long-term survival owing to advances in treatment. However, cancer treatment can cause gonadal dysfunction that leads to loss of fertility. Thus, it is important for clinical oncologists to consider fertility preservation in children, adolescents, and young adults with cancer who are expected to have a favorable outcome and may wish to have children in the future. Sometimes, fertility preservation has to be abandoned depending on the stage of the cancer and the general condition of the patient, because fertility preservation procedures may unacceptably delay cancer treatment or be too risky for the patient...
March 26, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29561302/international-study-of-primary-mucinous-ovarian-carcinomas-managed-at-tertiary-medical-centers
#5
Jennifer J Mueller, Henrik Lajer, Berit Jul Mosgaard, Slim Bach Hamba, Philippe Morice, Sebastien Gouy, Yaser Hussein, Robert A Soslow, Brooke A Schlappe, Qin C Zhou, Alexia Iasonos, Claus Høgdall, Alexandra Leary, Roisin E OʼCearbhaill, Nadeem R Abu-Rustum
OBJECTIVE: We sought to describe a large, international cohort of patients diagnosed with primary mucinous ovarian carcinoma (PMOC) across 3 tertiary medical centers to evaluate differences in patient characteristics, surgical/adjuvant treatment strategies, and oncologic outcomes. METHODS: This was a retrospective review spanning 1976-2014. All tumors were centrally reviewed by an expert gynecologic pathologist. Each center used a combination of clinical and histologic criteria to confirm a PMOC diagnosis...
March 21, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29538257/obstetric-outcomes-in-women-with-early-bulky-cervical-cancer-downstaged-by-neoadjuvant-chemotherapy-to-allow-for-fertility-sparing-surgery-a-meta-analysis-and-metaregression
#6
Alexandros Laios, Jenneke Kasius, Anastasios Tranoulis, Alexandros Gryparis, Thomas Ind
OBJECTIVE: It is difficult to critically outline the optimal treatment for women with early-stage cervical cancer (eCC) wishing fertility preservation. Neoadjuvant chemotherapy (NAC) to downstage "bulky" eCC could potentially lead to fertility-sparing surgery (FSS) in a wider patient population. The rationale is to provide oncological safety balanced with maximal fertility effort. We aimed to obtain the most accurate fertility outcomes for eCC women treated with NAC followed by FSS and identify potential factors favoring fertility...
March 14, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29530556/-endometriosis-and-fertility-preservation-cngof-has-endometriosis-guidelines
#7
C Decanter, E M d'Argent, J Boujenah, C Poncelet, C Chauffour, P Collinet, P Santulli
Fertility preservation (FP) techniques are progressing rapidly these past few years thanks to the oocyte vitrification. Indication of FP techniques is now extended to non-oncological situation that may induce risk of premature ovarian failure. Ovarian endometriosis can lead to premature ovarian failure and further infertility due to the high risk of ovarian cysts recurrence and surgery. To date, there is no cohort study regarding FP and endometriosis as well as no recommendation. Our purpose is to review the arguments in favor of FP in this specific area and to elaborate strategies according to each clinical form...
March 9, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29527869/vitrification-of-human-oocytes
#8
Aila Coello, Antonio Pellicer, Ana Cobo
In recent years, growing evidence for the safety and efficiency of oocyte vitrification has made this technique be increasingly proposed for fertility preservation (FP). The populations who could benefit from FP include oncological patients who need the option to preserve their gametes before undergoing potential sterilizing treatment, patients with non oncologic conditions requiring gonadotoxic chemotherapy and women who wish to delay their motherhood for a variety of reasons. By vitrifying oocytes, women have the chance to conceive in the future, have their own genetic offspring and maintain their reproductive autonomy...
March 8, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29502284/fertility-preservation-for-female-cancer-patients
#9
REVIEW
Miyuki Harada, Yutaka Osuga
An improvement in the survival rates of cancer patients and recent advancements in assisted reproductive technologies have led to remarkable progress in oncofertility and fertility preservation treatments. Currently, for adults and postpubertal girls, oocyte or embryo cryopreservation is an established method. If their cancer treatment cannot be postponed for 2 weeks, ovarian tissue cryopreservation is offered as an experimental technique. For prepubertal girls, ovarian tissue cryopreservation is the only option...
March 3, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29491073/combined-oocyte-retrieval-and-robot-assisted-hysterectomy-in-a-super-morbidly-obese-patient-with-endometrial-carcinoma
#10
Esther H Chung, Paula C Brady, Kimberly Keefe Smith, Michelle R Davis, Michael G Muto, Rachel K Ashby, Elizabeth S Ginsburg
AIM: To report on the unique, innovative management of a super morbidly obese patient presenting for fertility preservation in the setting of Grade 2 endometrioid endometrial adenocarcinoma. CASE REPORT: A back-to-back oocyte retrieval and robot-assisted total laparoscopic hysterectomy (RA-TLH) with bilateral salpingo-oophorectomy (BSO) was performed in a 37-year-old nulligravid woman with super morbid obesity (BMI 63 kg/m2 ) with endometrial cancer. MAIN OUTCOME MEASURE: the successful retrieval of oocytes for fertility preservation and oncologic intervention via RA-TLH with BSO in the same operative and anesthetic episode...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29481385/fertility-preservation-toolkit-a-clinician-resource-to-assist-clinical-discussion-and-decision-making-in-pediatric-and-adolescent-oncology
#11
Matthew A Kemertzis, Harene Ranjithakumaran, Meredith Hand, Michelle Peate, Lynn Gillam, Maria McCarthy, Leanne Super, Sarah McQuillan, Sarah Drew, Yasmin Jayasinghe, Lisa Orme
PURPOSE: Fertility preservation (FP) discussions in children with cancer presents unique challenges due to ethical considerations, lack of models-of-care, and the triadic nature of discussions. This study evaluated a fertility toolkit for clinicians involved in FP discussions with pediatric, adolescent, and young adult patients and parents. MATERIALS AND METHODS: A survey-based, longitudinal study of clinicians at The Royal Children's Hospital Melbourne involved in FP discussions undertaken at 3 time-points: 2014, alongside an education session for baseline assessment of oncofertility practices (survey 1); after each toolkit use to evaluate case-specific implementation (survey 2); 2016, to evaluate impact on clinical practice (survey 3)...
February 23, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29467138/-pathways-patient-centred-decision-counselling-for-women-at-risk-of-cancer-related-infertility-a-protocol-for-a-comparative-effectiveness-cluster-randomised-trial
#12
Terri Lynn Woodard, Aubri S Hoffman, Laura C Crocker, Deborah A Holman, Derek B Hoffman, Jusheng Ma, Roland L Bassett, Viola B Leal, Robert J Volk
INTRODUCTION: National guidelines recommend that all reproductive-age women with cancer be informed of their fertility risks and offered referral to fertility specialists to discuss fertility preservation options. However, reports indicate that only 5% of patients have consultations, and rates of long-term infertility-related distress remain high. Previous studies report several barriers to fertility preservation; however, initial success has been reported using provider education, patient decision aids and navigation support...
February 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29461339/neoadjuvant-bleomycin-etoposide-and-cisplatin-bep-chemotherapy-in-the-treatment-of-extensively-advanced-yolk-sac-tumors-a-single-center-experience
#13
Gong-Yi Zhang, Rong Zhang, Ling-Ying Wu, Bin Li, Shu-Min Li
OBJECTIVE: This study aimed to investigate the role of neoadjuvant bleomycin, etoposide, and cisplatin (BEP) regimen in patients with extensively advanced yolk sac tumors (YSTs). METHODS: Between July 1982 and December 2015, a total of 58 patients with YST were initially treated at our institution, among which 18 were evaluated to be inoperable and received neoadjuvant BEP regimen. They were either too debilitated by the disease [Eastern Cooperative Oncology Group Performance Status Scale (ECOG ps) ≥2] to undergo a major surgery or were with too extensively disseminated lesions to be optimally debulked...
February 15, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29435699/psychosocial-benefits-of-fertility-preservation-for-young-cancer-patients
#14
Juliana Assi, Juliana Santos, Tatiana Bonetti, Paulo C Serafini, Eduardo L A Motta, Mauricio Barbour Chehin
PURPOSE: The risk of ovarian failure after radiotherapy and/or chemotherapy is a concern among oncologic women. There is no doubt regarding the psycho-emotional benefits of fertility preservation (FP) after a cancer diagnosis because concerns about biological conception are a source of anxiety and can even affect the patient's cancer recovery. The aim of this study was to evaluate oncology patients' feelings, concerns, and life quality impacts related to FP. METHODS: This qualitative cross-sectional study was based on a questionnaire administered to a selected group of women diagnosed with cancer who underwent FP...
February 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29425251/is-oxygen-availability-a-limiting-factor-for-in-vitro-folliculogenesis
#15
Riccardo Talevi, Sam Sudhakaran, Vincenza Barbato, Anna Merolla, Sabrina Braun, Maddalena Di Nardo, Valentina Costanzo, Raffaele Ferraro, Nicola Iannantuoni, Gerardo Catapano, Roberto Gualtieri
Transplantation of ovarian tissue for the preservation of fertility in oncological patients is becoming an accepted clinical practice. However, the risk of re-introducing tumour cells at transplantation has stirred an increased interest for complete in vitro folliculogenesis. This has not yet been achieved in humans possibly for the lack of knowledge on the environmental milieu that orchestrates folliculogenesis in vivo. The main aim of this study was to investigate the effect of oxygen availability on follicle health and growth during in vitro culture of ovarian tissue strips...
2018: PloS One
https://www.readbyqxmd.com/read/29390200/overview-tumour-disease-and-oncologic-therapy-during-pregnancy
#16
Sebastian Findeklee
Newly diagnosed cancer in pregnancy is an issue with increasing importance, because fulfilling the wish to have a child is shifted later in life. Tumour disease is diagnosed in around 0.1% of all pregnancies in Germany. Most common tumour entities involve the breast, the cervix and the hematopoietic system. As tumour prognosis is not negatively affected by pregnancy and gestation does not disclude oncologic therapy it is important to plan treatment immediately. Oncologic surgery preserving the uterus is not at all limited...
February 1, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29389500/fertility-decision-making-under-certainty-and-uncertainty-in-cancer-patients
#17
Hiroko Komatsu, Kaori Yagasaki, Hideko Yamauchi
OBJECTIVE: The objective of this study was to understand how reproductive-age women with breast cancer make fertility-related decisions. METHODS: Using grounded theory methodology, we collected data from 11 reproductive-age women with breast cancer between March and August 2016. Verbatim transcriptions were analyzed using constant comparative analysis and open, axial, and selective coding. RESULTS: "Fertility Decision-Making under Certainty and Uncertainty" emerged as a core category...
March 2018: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/29387409/fertility-preservation-in-post-pubescent-female-cancer-patients-a-practical-guideline-for-clinicians
#18
Amirrtha Srikanthan, Eitan Amir, Philippe Bedard, Meredith Giuliani, David Hodgson, Stephanie Laframboise, Anca Prica, Karen Yee, Ellen Greenblatt, Jeremy Lewin, Abha Gupta
Increasing accessibility of fertility preservation (FP) options has permitted women to retain fertility following anticancer therapies. Several published guidelines have made recommendations for FP however their implementation into practice is currently unknown. In this review, we aim to provide oncology clinicians practical information about FP options for post-pubescent female cancer patients and recommendations for care delivery in order to answer preliminary questions and help triage whether FP referral is appropriate...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29385139/can-simple-trachelectomy-or-conization-show-comparable-survival-rate-compared-with-radical-trachelectomy-in-ia1-cervical-cancer-patients-with-lymphovascular-space-invasion-who-wish-to-save-fertility-a-systematic-review-and-guideline-recommendation
#19
Seung-Hyuk Shim, Myong Cheol Lim, Hyun Jung Kim, Maria Lee, Eun Ji Nam, Jung Yun Lee, Yoo-Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong-Won Lee, Jae-Weon Kim, Duk-Soo Bae, Jong-Min Lee
OBJECTIVE: This study aims to analyze the published literatures on the effect of less radical fertility-preserving procedures, such as conization or simple trachelectomy, on oncological outcomes in IA1 cervical cancer patients with lymphovascular space invasion (LVSI) through a systematic-review. METHODS: The EMBASE and MEDLINE databases and Cochrane Library were searched for published studies reporting the oncological outcomes of conization/simple trachelectomy in these patients, through April 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29376013/fertility-preservation-for-patients-with-gynecologic-malignancies-the-korean-society-for-fertility-preservation-clinical-guidelines
#20
REVIEW
Sanghoon Lee, Seul Ki Kim, Kyung Joo Hwang, Tak Kim, Seok Hyun Kim
Fertility preservation plays a central role in cancer care since an increasingly large number of cancer patients are surviving as a result of improvements in diagnostic and therapeutic strategies. Physicians who take part in the initial diagnosis and management of gynecologic cancer should understand the importance of fertility preservation. Since indications for fertility preservation are limited to early-stage gynecologic cancer, a surgeon must carefully consider each indication. Before performing fertility-sparing surgery, health professionals should compare its oncologic and pregnancy outcomes with those of other standard treatments...
December 2017: Clinical and Experimental Reproductive Medicine
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