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Fertility preservation oncology

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https://www.readbyqxmd.com/read/29435699/psychosocial-benefits-of-fertility-preservation-for-young-cancer-patients
#1
Juliana Assi, Juliana Santos, Tatiana Bonetti, Paulo C Serafini, Eduardo L A Motta, Mauricio Barbour Chehin
PURPOSE: The risk of ovarian failure after radiotherapy and/or chemotherapy is a concern among oncologic women. There is no doubt regarding the psycho-emotional benefits of fertility preservation (FP) after a cancer diagnosis because concerns about biological conception are a source of anxiety and can even affect the patient's cancer recovery. The aim of this study was to evaluate oncology patients' feelings, concerns, and life quality impacts related to FP. METHODS: This qualitative cross-sectional study was based on a questionnaire administered to a selected group of women diagnosed with cancer who underwent FP...
February 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29425251/is-oxygen-availability-a-limiting-factor-for-in-vitro-folliculogenesis
#2
Riccardo Talevi, Sam Sudhakaran, Vincenza Barbato, Anna Merolla, Sabrina Braun, Maddalena Di Nardo, Valentina Costanzo, Raffaele Ferraro, Nicola Iannantuoni, Gerardo Catapano, Roberto Gualtieri
Transplantation of ovarian tissue for the preservation of fertility in oncological patients is becoming an accepted clinical practice. However, the risk of re-introducing tumour cells at transplantation has stirred an increased interest for complete in vitro folliculogenesis. This has not yet been achieved in humans possibly for the lack of knowledge on the environmental milieu that orchestrates folliculogenesis in vivo. The main aim of this study was to investigate the effect of oxygen availability on follicle health and growth during in vitro culture of ovarian tissue strips...
2018: PloS One
https://www.readbyqxmd.com/read/29390200/overview-tumour-disease-and-oncologic-therapy-during-pregnancy
#3
Sebastian Findeklee
Newly diagnosed cancer in pregnancy is an issue with increasing importance, because fulfilling the wish to have a child is shifted later in life. Tumour disease is diagnosed in around 0.1% of all pregnancies in Germany. Most common tumour entities involve the breast, the cervix and the hematopoietic system. As tumour prognosis is not negatively affected by pregnancy and gestation does not disclude oncologic therapy it is important to plan treatment immediately. Oncologic surgery preserving the uterus is not at all limited...
February 1, 2018: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29389500/fertility-decision-making-under-certainty-and-uncertainty-in-cancer-patients
#4
Hiroko Komatsu, Kaori Yagasaki, Hideko Yamauchi
OBJECTIVE: The objective of this study was to understand how reproductive-age women with breast cancer make fertility-related decisions. METHODS: Using grounded theory methodology, we collected data from 11 reproductive-age women with breast cancer between March and August 2016. Verbatim transcriptions were analyzed using constant comparative analysis and open, axial, and selective coding. RESULTS: "Fertility Decision-Making under Certainty and Uncertainty" emerged as a core category...
March 2018: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/29387409/fertility-preservation-in-post-pubescent-female-cancer-patients-a-practical-guideline-for-clinicians
#5
Amirrtha Srikanthan, Eitan Amir, Philippe Bedard, Meredith Giuliani, David Hodgson, Stephanie Laframboise, Anca Prica, Karen Yee, Ellen Greenblatt, Jeremy Lewin, Abha Gupta
Increasing accessibility of fertility preservation (FP) options has permitted women to retain fertility following anticancer therapies. Several published guidelines have made recommendations for FP however their implementation into practice is currently unknown. In this review, we aim to provide oncology clinicians practical information about FP options for post-pubescent female cancer patients and recommendations for care delivery in order to answer preliminary questions and help triage whether FP referral is appropriate...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29385139/can-simple-trachelectomy-or-conization-show-comparable-survival-rate-compared-with-radical-trachelectomy-in-ia1-cervical-cancer-patients-with-lymphovascular-space-invasion-who-wish-to-save-fertility-a-systematic-review-and-guideline-recommendation
#6
Seung-Hyuk Shim, Myong Cheol Lim, Hyun Jung Kim, Maria Lee, Eun Ji Nam, Jung Yun Lee, Yoo-Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong-Won Lee, Jae-Weon Kim, Duk-Soo Bae, Jong-Min Lee
OBJECTIVE: This study aims to analyze the published literatures on the effect of less radical fertility-preserving procedures, such as conization or simple trachelectomy, on oncological outcomes in IA1 cervical cancer patients with lymphovascular space invasion (LVSI) through a systematic-review. METHODS: The EMBASE and MEDLINE databases and Cochrane Library were searched for published studies reporting the oncological outcomes of conization/simple trachelectomy in these patients, through April 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29376013/fertility-preservation-for-patients-with-gynecologic-malignancies-the-korean-society-for-fertility-preservation-clinical-guidelines
#7
REVIEW
Sanghoon Lee, Seul Ki Kim, Kyung Joo Hwang, Tak Kim, Seok Hyun Kim
Fertility preservation plays a central role in cancer care since an increasingly large number of cancer patients are surviving as a result of improvements in diagnostic and therapeutic strategies. Physicians who take part in the initial diagnosis and management of gynecologic cancer should understand the importance of fertility preservation. Since indications for fertility preservation are limited to early-stage gynecologic cancer, a surgeon must carefully consider each indication. Before performing fertility-sparing surgery, health professionals should compare its oncologic and pregnancy outcomes with those of other standard treatments...
December 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29346308/tissue-engineering-to-improve-immature-testicular-tissue-and-cell-transplantation-outcomes-one-step-closer-to-fertility-restoration-for-prepubertal-boys-exposed-to-gonadotoxic-treatments
#8
REVIEW
Federico Del Vento, Maxime Vermeulen, Francesca de Michele, Maria Grazia Giudice, Jonathan Poels, Anne des Rieux, Christine Wyns
Despite their important contribution to the cure of both oncological and benign diseases, gonadotoxic therapies present the risk of a severe impairment of fertility. Sperm cryopreservation is not an option to preserve prepubertal boys' reproductive potential, as their seminiferous tubules only contain spermatogonial stem cells (as diploid precursors of spermatozoa). Cryobanking of human immature testicular tissue (ITT) prior to gonadotoxic therapies is an accepted practice. Evaluation of cryopreserved ITT using xenotransplantation in nude mice showed the survival of a limited proportion of spermatogonia and their ability to proliferate and initiate differentiation...
January 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29346023/fertility-preservation-in-pediatric-oncology-patients-new-perspectives
#9
Chiara Gertosio, Mariasole Magistrali, Paola Musso, Cristina Meazza, Mauro Bozzola
Over the past 30 years, advances in antineoplastic treatment led to a significant increase in the survival of patients with childhood cancer. In Europe and the United States, 82% of children, adolescents, and young adults survive 5 years from the cancer diagnosis and the majority achieves long-term survival into adulthood. The impact of cancer therapy on fertility is related to the age of the patient and to the duration, dose/intensity, and type of treatment. Exposure to chemotherapy or to radiation to gonads or pituitary brings long-term complications of cancer-directed therapies that include effects on reproductive capacity...
January 18, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29338854/long-term-outcomes-in-cancer-patients-who-did-or-did-not-pursue-fertility-preservation
#10
Molly B Moravek, Rafael Confino, Kristin N Smith, Ralph R Kazer, Susan C Klock, Angela K Lawson, William J Gradishar, Mary Ellen Pavone
OBJECTIVE: To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle-specific (CS) protocols for FP. DESIGN: Retrospective cohort. SETTING: Single urban academic institution. PATIENT(S): Oncology patients who contacted the FP patient navigator, 2005-2015. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Time to cancer treatment, disease-free survival, and reproductive outcomes in FP versus no-FP patients and cycle outcomes for RS versus CS protocols...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29315172/fertility-preservation-services-for-women-with-newly-diagnosed-cancer-a-national-assessment
#11
William D Winkelman, Mitchell P Rosen, Evelyn Mok-Lin
OBJECTIVE: To study the resources available for cancer patients once referred for fertility preservation. MATERIALS AND METHODS: Cross-sectional study clinics that are members of the Society for Assisted Reproductive Technology assess support for fertility preservation. RESULTS: Surveys were distributed to a total of 1135 members at 394 Society for Assisted Reproductive Technology clinics. Responses were received from 99 individuals representing a total of 84 unique clinics (21...
January 8, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29298394/fertility-preservation-for-medical-reasons-in-girls-and-women-british-fertility-society-policy-and-practice-guideline
#12
Ephia Yasmin, Neerujah Balachandren, Melanie C Davies, Georgina L Jones, Sheila Lane, Raj Mathur, Lisa Webber, Richard A Anderson
Fertility preservation in the female poses several challenges due to the invasive nature of the techniques available to achieve it. The guideline aims to bring together the evidence available for the measures for fertility preservation and their outcome. The guideline addresses fertility preservation for medical reasons and includes both oncological and non-oncological causes. The techniques that the guideline considers are: (i) embryo and oocyte cryopreservation; (ii) ovarian tissue cryopreservation; (iii) GnRH agonist suppression and (iv) ovarian transposition...
January 3, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29286217/knowledge-and-perceptions-about-cancer-treatment-associated-infertility-among-young-patients-at-a-tertiary-care-hospital-in-pakistan
#13
Asif Husain Osmani, Ghulam Haider, Shaharzad Ali, Faiza Ali, Munazza Irfan, Dur e Fatima
Introduction: Infertility after cancer treatment can cause significant emotional stress and grief for cancer survivors. In this study we assessed knowledge and perceptions among young cancer patients regarding the topic of cancer and infertility related to different treatment options. Material and Methods: This cross-sectional study was conducted on young cancer patients in the Clinical Oncology Department, JPMC, Karachi, from January to August 2013. Patients were requested to fill in questionnaires. Comparisons between gender and age groups were performed using the Student’s t test and Pearson’s Chi-squared...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29242280/results-of-fertility-sparing-surgery-for-expansile-and-infiltrative-mucinous-ovarian-cancers
#14
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: No series had been reported focusing on the results of fertility-sparing surgery in stage I mucinous ovarian cancers according to histotype (infiltrative vs. expansile). Investigating such outcomes was the aim of the present study. MATERIALS AND METHODS: The present study was a retrospective analysis of patients treated conservatively with preservation of the uterus and contralateral ovary from 1976 to 2016. The pathology of the tumors was reviewed by two expert pathologists according to the 2014 World Health Organization (WHO) classification criteria...
December 14, 2017: Oncologist
https://www.readbyqxmd.com/read/29221705/female-fertility-preservation-in-the-pediatric-and-adolescent-cancer-patient-population
#15
REVIEW
Gabriela N Algarroba, Joseph S Sanfilippo, Hanna Valli-Pulaski
The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patients, there are several barriers and ethical considerations to fertility preservation in the pediatric and adolescent female population...
October 26, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29221696/fertility-preservation-in-pediatric-subspecialties-a-pilot-needs-assessment-beyond-oncology
#16
Branavan Vakeesan, Danielle R Weidman, Anne Marie Maloney, Lisa Allen, Armando J Lorenzo, Abha A Gupta
Physicians from 6 non-oncology pediatric subspecialties were surveyed about fertility preservation (FP) to assess education/service needs. Almost all (96%; 25 of 26) reported having patients at risk of infertility; however, only 58% (15 of 26) had discussed FP with patients' families. Most subspecialists (92%; 23 of 25) would like access to an FP program. Our data support exploring the expansion of FP programs beyond oncology.
December 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29221621/-fertility-preservation-in-oncology
#17
REVIEW
Laure Chaput, Anne-Sophie Grémeau, Solène Vorilhon, Hanae Pons, Cécile Chabrot, Victoria Grèze, Jean-Luc Pouly, Florence Brugnon
Since the improvement of cancer diagnosis and treatment, survival rates of these patients increase. Gonadal damages are frequent consequences of cancer treatments with different evidence of impaired fertility. In this context, fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatments. Different preservation approaches may be proposed depending on patient age, sex, cancer type and type of treatment. The indications of fertility preservation depend on sexual maturity...
December 5, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29203995/management-of-borderline-ovarian-tumors-still-a-gray-zone
#18
Nidhi Nayyar, Prerna Lakhwani, Ashish Goel, Pankaj Kr Pande, Kapil Kumar
Borderline ovarian tumors (BOTs) are a heterogeneous group of non-invasive epithelial ovarian tumors that occur at a younger age, present in early stage, frequently associated with infertility but are easily curable. Although they may have symptomatic long-term recurrences, they have an excellent prognosis in spite of peritoneal spread. Among the epithelial tumors of the ovary, BOTs fall in the spectrum lying between cystadenomas (benign) and cystadenocarcinomas (malignant). Their oncological behavior is more aggressive than benign ovarian tumors but relatively less than that of malignant ovarian tumors...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29198423/fertility-protection-complications-of-surgery-and-results-of-removal-and-transplantation-of-ovarian-tissue
#19
Matthias W Beckmann, Ralf Dittrich, Laura Lotz, Karin van der Ven, Hans H van der Ven, Jana Liebenthron, Matthias Korell, Torsten Frambach, Marc Sütterlin, Roxana Schwab, Stefan Seitz, Andreas Müller, Michael von Wolff, Felix Häberlin, Melanie Henes, Katharina Winkler-Crepaz, Jan S Krüssel, Ariane Germeyer, Bettina Toth
Fertility-preserving measures are becoming important for patients receiving oncological treatment. One method involves cryopreservation of ovarian tissue and transplanting it when treatment is completed. We report complications resulting from surgical and fertility medicine, and the results of procedures for the removal and transplantation of ovarian tissue carried out within the FertiProtekt network. A survey using a structured questionnaire was conducted among the FertiProtekt network centres between November 2015 and June 2016...
November 9, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29184796/oncofertility-in-sarcoma-patients
#20
REVIEW
Diana M Lopategui, Raphael Yechieli, Ranjith Ramasamy
Treatment for sarcoma can significantly decrease fertility, both due to the irradiation of gonads, and the impact of chemotherapy on gametogenesis. Infertility in cancer survivors causes significant regret and decreased quality of life in their adulthood. As this cancer mainly affects children and young adults, fertility preservation is an essential part of survivorship care, however it remains one of the least implemented services in adolescent and young adult cancer patients. Success of fertility preservation is highly dependent on the referral prior to oncologic treatment...
October 2017: Translational Andrology and Urology
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