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https://www.readbyqxmd.com/read/29780604/effect-of-long-term-high-altitude-exposure-on-cardiovascular-autonomic-adjustment-during-rest-and-post-exercise-recovery
#1
Prem Bhattarai, Bishnu H Paudel, Dilip Thakur, Balkrishna Bhattarai, Bijay Subedi, Rita Khadka
Background: Despite the successful adaptation to high altitude, some differences do occur due to long term exposure to the hypoxic environment. The effect of long term high altitude exposure on cardiac autonomic adjustment during basal and post-exercise recovery is less known. Thus we aimed to study the differences in basal cardiac autonomic adjustment and its response to exercise in highlanders and to compare it with lowlanders. Methods: The study was conducted on 29 healthy highlander males who were born and brought up at altitude of 3000 m and above from the sea level, their cardiac autonomic adjustment was compared with age, sex, physical activity and ethnicity-matched 29 healthy lowlanders using Heart Rate Variability (HRV) during rest and recovery from sub-maximal exercise (3 m step test)...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29777715/association-between-plasma-ceramides-and-inducible-myocardial-ischemia-in-patients-with-established-or-suspected-coronary-artery-disease-undergoing-myocardial-perfusion-scintigraphy
#2
Alessandro Mantovani, Stefano Bonapace, Gianluigi Lunardi, Matteo Salgarello, Clementina Dugo, Guido Canali, Christopher D Byrne, Stefania Gori, Enrico Barbieri, Giovanni Targher
BACKGROUND: Recent studies have suggested that specific plasma ceramides are independently associated with major adverse cardiovascular events in patients with coronary artery disease (CAD), but it is currently unknown whether plasma ceramide levels are associated with stress-induced reversible myocardial ischemia. METHODS: We measured six previously identified high-risk plasma ceramide molecules [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0), and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD who underwent either exercise or dypiridamole myocardial perfusion scintigraphy (MPS) for various clinical indications...
May 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29775407/effect-of-healthy-aging-and-sex-on-middle-cerebral-artery-blood-velocity-dynamics-during-moderate-intensity-exercise
#3
Jaimie L Ward, Jesse C Craig, Yumei Liu, Eric Dennis Vidoni, Rebecca Malesky, David C Poole, Sandra A Billinger
Cerebral blood flow (CBF) velocity measured in the middle cerebral artery (MCAV ) increases with finite kinetics during moderate intensity exercise and both the amplitude and dynamics of the response provide invaluable insights into the controlling mechanisms. The MCAV response following exercise onset is well fit to an exponential model in young individuals but remains to be characterized in their older counterparts. The responsiveness of vasomotor control degrades with advancing age, especially in skeletal muscle, and we tested the hypothesis that older subjects would evince a slower and reduced MCAV response to exercise...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29773993/diabetic-cardiomyopathy-impact-of-biological-sex-on-disease-development-and-molecular-signatures
#4
REVIEW
Ryan Toedebusch, Anthony Belenchia, Lakshmi Pulakat
Diabetic cardiomyopathy refers to a unique set of heart-specific pathological variables induced by hyperglycemia and insulin resistance. Given that cardiovascular disease (CVD) is the leading cause of death in the world, and type 2 diabetes incidence continues to rise, understanding the complex interplay between these two morbidities and developing novel therapeutic strategies is vital. Two hallmark characteristics specific to diabetic cardiomyopathy are diastolic dysfunction and cardiac structural mal-adaptations, arising from cardiac cellular responses to the complex toxicity induced by hyperglycemia with or without hyperinsulinemia...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29769247/dementia-and-physical-activity-dapa-trial-of-moderate-to-high-intensity-exercise-training-for-people-with-dementia-randomised-controlled-trial
#5
Sarah E Lamb, Bart Sheehan, Nicky Atherton, Vivien Nichols, Helen Collins, Dipesh Mistry, Sukhdeep Dosanjh, Anne Marie Slowther, Iftekhar Khan, Stavros Petrou, Ranjit Lall
OBJECTIVE: To estimate the effect of a moderate to high intensity aerobic and strength exercise training programme on cognitive impairment and other outcomes in people with mild to moderate dementia. DESIGN: Multicentre, pragmatic, investigator masked, randomised controlled trial. SETTING: National Health Service primary care, community and memory services, dementia research registers, and voluntary sector providers in 15 English regions. PARTICIPANTS: 494 people with dementia: 329 were assigned to an aerobic and strength exercise programme and 165 were assigned to usual care...
May 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29768300/the-hemodynamic-response-to-constant-dobutamine-infusion-the-effect-of-adrb1-389-polymorphism-and-sex
#6
Dotan Yogev, Maamoun Basheer, Amichai Perlman, Simcha Blotnick, Yoseph Caraco, Mordechai Muszkat
OBJECTIVES: Prolonged activation of the β-1 adrenergic receptor (ADRB1) is associated with receptor desensitization. This process has been suggested to have important pathophysiological and clinical implications in conditions such as congestive heart failure. The contribution of genetic factors to this process is a patient of ongoing research. We have previously shown that the ADRB1 389 polymorphism affects the response to incremental dose infusion of the ADRB agonist dobutamine. The aim of the current study was to determine whether the ADRB1 389 polymorphism affects the hemodynamic response to constant dose infusion of dobutamine in healthy patients...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29767671/significance-of-an-increase-in-diastolic-blood-pressure-during-a-stress-test-in-terms-of-comorbidities-and-long-term-total-and-cv-mortality
#7
Nóra Sydó, Tibor Sydó, Karina A Gonzalez Carta, Nasir Hussain, Béla Merkely, Joseph G Murphy, Ray W Squires, Francisco Lopez-Jimenez, Thomas G Allison
Background: A decrease in diastolic blood pressure (DBP) with exercise is considered normal, but the significance of an increase in DBP has not been validated. Our aim was to determine the relationship of DBP increasing on a stress test regarding comorbidities and mortality. Methods: Our database was reviewed from 1993-2010 using the first stress test of a patient. Non-Minnesota residence, baseline CV disease, rest DBP <60 or >100 mmHg, and age <30 or ≥80 were exclusion criteria...
May 15, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29765176/impairments-of-postural-control-functional-performance-and-strength-in-morbidly-obese-patients-awaiting-bariatric-surgery-in-comparison-to-healthy-individuals
#8
Max Lennart Eckstein, Jimmy Bradley Lawrence, Christoph Otto, Peggy Kotsch, Janin Messerschmidt, Richard Michael Bracken, Othmar Moser
[Purpose] There is a lack of information evaluating specific markers of performance in patients awaiting bariatric surgery. We aimed to assess the postural control, functional performance, strength and endurance performance for morbidly obese patients awaiting bariatric surgery compared to lean controls. [Subjects and Methods] All parameters were assessed by modified Y-balance test, timed-up-and-go-test, maximum strength testing on resistance exercise equipment and cardio-pulmonary exercise testing on a cycle ergometer in 10 morbidly obese patients awaiting bariatric surgery and 10 age- and sex-matched lean controls...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29762052/effects-of-physical-exercise-on-adiponectin-leptin-and-inflammatory-markers-in-childhood-obesity-systematic-review-and-meta-analysis
#9
Felice Sirico, Antonio Bianco, Giovanni D'Alicandro, Clotilde Castaldo, Stefania Montagnani, Rocco Spera, Franca Di Meglio, Daria Nurzynska
BACKGROUND: New findings on adipose tissue physiology and obesity-associated inflammation status suggest that modification of the adipokine level can be relevant for the long-term prevention of obesity-associated chronic disease. OBJECTIVES: The scope of the present study was to investigate the effectiveness of physical exercise in reducing the systemic inflammation related to obesity in children. METHODS: We conducted a systematic review with meta-analysis of controlled randomized trials, identified through electronic database search, which investigated the effect of physical exercise, without concomitant dietary intervention, on adiponectin, leptin, and/or other inflammatory markers in children up to age 18 years with a body mass index greater than the 95th percentile for age and sex...
May 15, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/29759909/the-predictive-value-of-arteriogenic-erectile-dysfunction-for-coronary-artery-disease-in-men
#10
Sherif Salah Azab, Hossam El Din Hosni, Taha A El Far, Nashaat Nabil Ismail, Yasser K El Bakdady, Ahmed F Mohamed
BACKGROUND: Erectile dysfunction (ED) is assumed to be connected with vascular disease caused by endothelial dysfunction, and characterized by the incapability of the smooth muscle cells lining the arterioles to relax, therefore, inhibit vasodilatation. AIM: To assess the predictive value of arteriogenic ED for coronary artery disease in men above the age of 40 years. METHODS: 75 Patients reporting arteriogenic ED and 25 men with normal erectile function were enrolled in the study...
May 11, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29759629/circadian-variation-of-ventricular-arrhythmias-in-catecholaminergic-polymorphic-ventricular-tachycardia
#11
Christina Y Miyake, S Yukiko Asaki, Gregory Webster, Richard J Czosek, Joseph Atallah, Kishor Avasarala, Sri O Rao, Patricia E Thomas, Jeffrey J Kim, Santiago O Valdes, Caridad de la Uz, Yunfei Wang, Xander H T Wehrens, Dominic Abrams
OBJECTIVES: The aim of this paper was to investigate whether ventricular arrhythmias in children with catecholaminergic polymorphic ventricular tachycardia (CPVT) show circadian patterns. BACKGROUND: Circadian arrhythmic patterns have been established in long QT, Brugada, and early repolarization, but have not been investigated in CPVT. METHODS: This is a multicenter, retrospective review of pediatric CPVT patients, age <21 years at diagnosis...
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29757822/an-exploration-of-the-impact-of-the-open-gym-scheduling-model-of-cardiovascular-rehabilitation-on-completion-attendance-and-health-outcomes
#12
Matthew C Whited, Jordan M Ellis, John Taylor Freeman, Ansley T Corson, Stacey B Greenway, Andrew M Busch, Amanda L Whited, Samuel F Sears
PURPOSE: To explore the effects of implementation of the "Open Gym" (OG) scheduling model of cardiovascular rehabilitation administration on the rate of patient engagement and change in commonly measured clinical outcomes. Little data exist on the potential benefits of the OG model on patient completion, attendance, and clinical outcomes. METHODS: A retrospective chart review was conducted that included the 1-y period both before and after OG model implementation...
May 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29756638/sex-differences-in-diaphragmatic-fatigue-the-cardiovascular-response-to-inspiratory-resistance
#13
Joseph F Welch, Bruno Archiza, Jordan A Guenette, Christopher R West, A William Sheel
KEY POINTS: Diaphragmatic fatigue (DF) elicits a sympathetically mediated metaboreflex resulting in increased heart rate, blood pressure and limb vascular resistance. Women may be more resistant to DF compared to men and therefore, it was hypothesised that women would experience an attenuated inspiratory muscle metaboreflex during inspiratory pressure-threshold loading (PTL) performed to task failure. At the time of PTL task failure, the severity of DF was not different between sexes; however, inspiratory muscle endurance time was significantly longer in women than men...
May 14, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29756416/testosterone-and-sarcopenia
#14
REVIEW
Myung Jun Shin, Yun Kyung Jeon, In Joo Kim
Aging affects metabolism, leading to physiological and functional impairments, and is also related to changes in body composition, including reduced skeletal muscle mass and increased body fat. These changes are correlated with the pathophysiology of sarcopenia, which is defined as age-related loss of skeletal muscle mass and strength. Low testosterone levels are associated with unfavorable body composition changes, and sex hormones decrease with aging. Androgen deficiency, along with lack of exercise and poor nutrition, may be among the modifiable contributors to sarcopenia...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29754451/maternal-exercise-season-and-sex-modify-the-human-fetal-circadian-rhythm
#15
Julie Sletten, Germaine Cornelissen, Jørg Assmus, Torvid Kiserud, Susanne Albrechtsen, Jörg Kessler
AIM: The knowledge on circadian rhythmicity is rapidly expanding. We aimed to define the longitudinal development of the circadian heart rate rhythm in the human fetus in an unrestricted, out-of-hospital setting, and to examine the effects of maternal physical activity, season and fetal sex. METHODS: We recruited 48 women with low-risk singleton pregnancies. Using a portable monitor for continuous fetal electrocardiography, fetal heart rate recordings were obtained around gestational weeks 24, 28, 32 and 36...
May 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29753804/the-association-between-serum-vitamin-d-level-and-cognitive-function-in-older-adults-cooper-center-longitudinal-study
#16
Andjelka Pavlovic, Katelyn Abel, Carolyn E Barlow, Stephen W Farrell, Myron Weiner, Laura F DeFina
Low blood level of vitamin D and low physical activity have been linked to the development of cognitive impairment in older adults. The purpose of the present study was to examine the relationship between serum vitamin D and cognition as measured via the Montreal Cognitive Assessment (MoCA) in a healthy, older population. The study sample consisted of 4358 patients from the Cooper Clinic in Dallas, TX. All participants underwent a maximal graded exercise test to determine cardiorespiratory fitness (CRF). Cognitive impairment was defined as a MoCA score <25...
May 10, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29753800/effect-of-sexual-intercourse-on-lower-extremity-muscle-force-in-strength-trained-men
#17
Leah M Valenti, Claudia Suchil, Gabriel Beltran, Roman C Rogers, Emily A Massey, Todd A Astorino
BACKGROUND: Sex has been deemed taboo for athletic performance going back to ancient Rome and Greece, as the act of sex was thought to promote ease and a sense of relaxation. AIM: This study examined the effect of sexual intercourse completed 12 hours before a bout of isokinetic dynamometry on muscle force production in strength-trained men. METHODS: 12 Healthy physically active men (age = 25.6 ± 3.8 years) who were sexually active participated in this study...
May 9, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29753373/dipstick-proteinuria-and-reduced-estimated-glomerular-filtration-rate-as-independent-risk-factors-for-osteoporosis
#18
Chun-Wu Tung, Yung-Chien Hsu, Ya-Hsueh Shih, Pey-Jium Chang, Chun-Liang Lin
BACKGROUND: Osteoporosis is associated with a poor quality of life and mortality. Proteinuria contributes to vitamin D deficiency and osteoblast dysfunction. The correlation between estimated glomerular filtration rate (eGFR) and bone density still remains elusive. Therefore, we sought to investigate whether reduced eGFR or proteinuria are independently associated with the osteoporotic risk. METHODS: We conducted a cross-sectional study using community-based health survey data from January 2004 to December 2008 in southern Taiwan...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29750822/prediction-equation-to-estimate-heart-rate-at-individual-ventilatory-threshold-in-female-and-male-obese-adults
#19
Gian Pietro Emerenziani, Dafne Ferrari, Maria Grazia Vaccaro, Maria Chiara Gallotta, Silvia Migliaccio, Andrea Lenzi, Carlo Baldari, Laura Guidetti
OBJECTIVE: Prescribing individualized moderate exercise intensity is a useful method to reach positive effects on health status in obese adults. This study aimed to establish a practical reference equation to estimate the heart rate (HR) at individual ventilatory threshold (IVT) (HRIVT). METHODS: One hundred sixty-one obese subjects were clinically evaluated and characterized by anthropometric and body composition. Participants performed the six-minute walking test (6-MWT) and the cardiopulmonary exercise test to assess IVT...
2018: PloS One
https://www.readbyqxmd.com/read/29748963/body-mass-index-and-cardiorespiratory-fitness-in-persons-with-multiple-sclerosis
#20
E Sebastião, R W Motl
OBJECTIVE: This study examined body fatness and its association with cardiorespiratory fitness (CRF) in persons with multiple sclerosis (pwMS) accounting for disability status. MATERIALS AND METHODS: This study involved a secondary data analysis from a previous study of 62 pwMS. Body fatness was indirect measured as body mass index (BMI), and CRF was measured as peak oxygen consumption from an incremental exercise test with spirometry. Participants were allocated into 3 different groups based on established BMI categories (ie, normal, overweight, and obese), and data were analyzed using SPSS...
May 11, 2018: Acta Neurologica Scandinavica
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