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Do Joong Park, Young Suk Park, Sang Yong Son, Ju-Hee Lee, Hye Seung Lee, Young Soo Park, Kyoung Ho Lee, Young Hoon Kim, Kyoung Un Park, Won Woo Lee, Soyeon Ahn, Sang-Hoon Ahn, Hyung-Ho Kim
BACKGROUND: Sentinel node navigation surgery (SNNS) in early gastric cancer (EGC) is technically feasible according to previous literature, however its long-term oncologic safety has not been reported. METHODS: A single-center, single-arm, phase II trial was conducted to determine the oncologic outcomes of laparoscopic sentinel node (SN) biopsy in clinical stage T1N0M0 gastric cancer patients. Cases with positive SNs on intraoperative pathologic examination underwent conventional gastrectomy with radical lymphadenectomy (SN-positive group), whereas those with negative SNs underwent laparoendoscopic-limited gastric resections without further lymph node dissections (SN-negative group)...
May 21, 2018: Annals of Surgical Oncology
Jingxu Li, Tingting Xia, Xinguan Yang, Xiao Dong, Jiamin Liang, Nanshan Zhong, Yubao Guan
Background: The differentiation of benign and malignant solitary pulmonary nodules (SPNs), especially subsolid nodules, is still challenging because of the small size, slow growth, and atypical imaging characteristics of these nodules. We aimed to determine the significance of mass growth rate (MGR) and mass doubling time (MDT) at follow-up CT of malignant SPNs. Methods: This retrospective study included 167 patients (169 SPNs, diameter 8-30 mm). Among the 169 SPNs, 114 malignant SPNs were classified into three types: pure ground-glass nodules (pGGNs), part-solid nodules (pSNs), and solid nodules (SNs)...
April 2018: Journal of Thoracic Disease
Guang Han, Srinivas R Popuri, Heather F Greer, Ruizhi Zhang, Lourdes Ferre-Llin, Jan-Willem G Bos, Wuzong Zhou, Michael J Reece, Douglas J Paul, Andrew R Knox, Duncan H Gregory
Anion exchange has been performed with nanoplates of tin sulfide (SnS) via "soft chemical" organic-free solution syntheses to yield layered pseudo-ternary tin chalcogenides on a 10 g-scale. SnS undergoes a topotactic transformation to form a series of S-substituted tin selenide (SnSe) nano/micro-plates with tuneable chalcogenide composition. SnS0.1 Se0.9 nanoplates were spark plasma sintered into phase-pure, textured, dense pellets, the ZT of which has been significantly enhanced to ≈1.16 from ≈0...
April 21, 2018: Chemical Science
Rama Gaur, P Jeevanandam
The present study reports the synthesis of SnS2 nanoparticles with different morphologies via a facile thermal decomposition approach. The SnS2 nanoparticles were synthesized using tin chloride and thiourea (or thioacetamide) in two different solvents (diphenyl ether and 1-octadecene). The SnS2 nanoparticles were extensively characterized using different analytical techniques. The crystallite size of SnS2 varies from 6.1 nm to 19.0 nm. Electron microscopy studies indicate that the SnS2 samples consist of flakes which assemble into different hierarchical structures such as ball dahlia, peony dahlia-like nanoflowers, nanoyarns and linear structures under different synthetic conditions...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Rukiye Ayranci, Fatma Ozturk Kirbay, Dilek Odaci Demirkol, Metin Ak, Suna Timur
Simple, rapid and effective fluorescence sensing platform have been fabricated using fluorescent conducting polymer surface. For this purpose, a rhodamine based electroactive monomer (RDC) and a functional group containing monomer (SNS) have been copolymerized to develop a conducting polymer based sensor platform having a fluorescence and enzyme-binding surface on ITO electrode. The proposed fluorescence sensing mechanism for detection glucose is related to the consumption of dissolved oxygen at double layer of the electrode which is fluorescence quenching agent by glucose-GOx reaction...
May 16, 2018: Methods and Applications in Fluorescence
Pengjiao Xi, Jianying Du, Huimin Liang, Jie Han, Zhaoxia Wu, Haomin Wang, Lu He, Qiming Wang, Haize Ge, Yongmei Li, Jie Xue, Derun Tian
BACKGROUND/AIMS: Obesity is increasingly becoming a major public health problem worldwide. Peripheral LKB1 inhibits white fat generation, but the effect of central LKB1 on diet-induced obesity (DIO) is unknown. Therefore, we examined whether LKB1 over-expression in the hypothalamus can inhibit the development of obesity. METHODS: Adult male Sprague-Dawley rats were anesthetized and placed in a stereotaxic apparatus. LKB1-AAV-EGFP (2.0 × 108 or 2.0 × 1010 vector genomes) or Control-AAV-EGFP (2...
May 9, 2018: Cellular Physiology and Biochemistry
Gabriel T do Vale, Janaina A Simplicio, Natália A Gonzaga, Rodrigo Yokota, Amanda A Ribeiro, Dulce E Casarini, Bruno S de Martinis, Carlos R Tirapelli
BACKGROUND AND AIMS: Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. METHODS: Male Wistar rats were treated with ethanol 20% (vol./vol.) or nebivolol (10 mg/kg/day, p. o., gavage), a selective β1 -adrenergic receptor antagonist...
April 30, 2018: Atherosclerosis
María Dolores Contreras-Aguilar, Damián Escribano, María Martín-Cuervo, Fernando Tecles, Jose Joaquín Cerón
BACKGROUND: The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biomarker, in horses with acute abdominal disease. Therefore, a prospective observational study was performed in which both biomarkers were analyzed in a group of horses with acute abdomen syndrome, and compared with a group of healthy control horses by an unpaired Student's t-test...
May 10, 2018: BMC Veterinary Research
Efrat Barel, Randa Abu-Shkara, Raul Colodner, Refaat Masalha, Lila Mahagna, Or Chen Zemel, Ami Cohen
Exposure to stress activates both the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). A growing body of research points to the contribution of sex hormones (testosterone, estrogen, and progesterone), the end products of the hypothalamus-pituitary-gonadal (HPG) axis, in modulating stress reactivity. The present study aimed at investigating the potential modulating role of sex hormones on HPA and SNS reactivity to psychosocial stress. The reactivity, induced by the Trier Social Stress Test, was analyzed by measuring the levels of cortisol and alpha-amylase (markers for SNS activity) in four saliva samples each of 21 men and 37 women (17 not using oral contraceptives and in their luteal phase, and 20 women using oral contraceptives)...
May 9, 2018: Journal of Neuroscience Research
Carlton P Frost, M Elizabeth Meyerand, Rasmus M Birn, Roxanne M Hoks, Erin C Walsh, Heather C Abercrombie
Adverse caregiving during development can produce long-lasting changes to neural, endocrine, and behavioral responses to stress, and is strongly related to elevated risk of adult psychopathology. While prior experience of adversity is associated with altered sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis activity, the underlying neural pathways are not completely understood. In a double-blind crossover study, we used diffusion tensor imaging (DTI) to examine whether variation in white matter structure predicts differences in HPA-SNS interactions as a function of early adversity...
2018: Frontiers in Neuroscience
Maria Maryanovich, Ali H Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara, Noboru Asada, Qiaozhi Wei, Xizhe Wang, Paul Ciero, Jianing Xu, Avigdor Leftin, Paul S Frenette
Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multilineage differentiation potential, contributing to the development of blood disorders. The bone marrow microenvironment has recently been suggested to influence HSC aging, but the underlying mechanisms remain largely unknown. Here we show that HSC aging critically depends on bone marrow innervation by the sympathetic nervous system (SNS), as loss of SNS nerves or adrenoreceptor β3 signaling in the bone marrow microenvironment of young mice led to premature HSC aging, as evidenced by appearance of HSC phenotypes reminiscent of physiological aging...
May 7, 2018: Nature Medicine
Eleonora Nacchiero, Michelangelo Vestita, Fabio Robusto, Michele Maruccia, Paolo Annoscia, Giuseppe Giudice
The presence of interval nodes (IN) in melanoma is testified in several studies and sometimes these lymph nodes can contain metastatic disease. Currently there are no guidelines about the management of patients with tumor-positive INs.We enrolled all patients affected by melanoma who underwent sentinel lymph node biopsy (SLNB) in a single institution. All patients with tumor-positive IN underwent the lymphadenectomy of the subsequent draining lymphatic field. Prognosis of IN+-patients was compared with subjects with positive SLNB in usual field through Kaplan-Meier and multivariate Cox regression analysis...
May 2018: Medicine (Baltimore)
Kouki Kuwabara, Okihide Suzuki, Noriyasu Chika, Kensuke Kumamoto, Toshiharu Minabe, Tomoo Fukuda, Eiichi Arai, Jun-Ichi Tamaru, Kiwamu Akagi, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida
Background: Muir-Torre syndrome (MTS) is currently considered as a clinical variant of Lynch syndrome (LS). The clinical significance of the screening of patients with MTS-associated cutaneous tumors for the identification of LS has not yet been established. In addition, the prevalence and molecular characteristics of mismatch repair (MMR) protein deficiency in such tumors has scarcely been investigated in the Japanese population. Methods: Immunohistochemistry (IHC) for MMR proteins (MLH1, MSH2, MSH6 and PMS2) was performed in formalin-fixed paraffin-embedded sections prepared from 16 sebaceous neoplasms (SNs) resected from 13 patients and 32 keratoacanthomas (KAs) resected from 31 patients at our institution between January 2005 and March 2014...
April 28, 2018: Japanese Journal of Clinical Oncology
Sumeet L Banker, Ada M Fenick, Li Qin, Jaideep S Talwalkar
Increasing use of social networking sites (SNS) among youth prompted professional organizations to urge pediatricians to promote healthy media use. Electronic questionnaires were distributed to 76 pediatric residents at one academic center measuring attitudes, practices, and familiarity with SNS. Of 43 respondents (response rate = 57%), most reported personal SNS use (98%) and familiarity with SNS used by youth (72%), and 88% agreed that pediatricians should provide counseling on SNS use. Only 5% felt they had adequate training on SNS use in children, and just 26% felt comfortable advising families...
April 1, 2018: Clinical Pediatrics
Abhijit Bera, Debranjan Mandal, Prasenjit Nanda Goswami, Arup Kumar Rath, Bhagavatula L V Prasad
A rational synthetic method that produces monodisperse and air stable metal sulfide colloidal quantum dots (CQDs) in organic nonpolar solvents using octyl dithiocarbamic acid (C8DTCA) as a sulfur source, is reported. The high reactivity of C8DTCA in presence of primary amines towards metal complexes is exploited to achieve this purpose. This novel technique is generic and can be applied to prepare diverse CQDs, like CdS, MnS, ZnS, SnS, In2S3, including more useful and in demand PbS CQDs and plasmonic nanocrystals of Cu2S...
May 1, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Wei Gao, Yongtao Li, Jianhua Guo, Muxun Ni, Ming Liao, Haojie Mo, Jingbo Li
Here we report ultrathin SnS1-xSex alloyed nanosheets synthesized via a narrow-gap physical vapour deposition approach. The SnS1-xSex alloy presents a uniform quadrangle shape with a lateral size of 5-80 μm and a thickness of several nanometers. Clear orthorhombic symmetries and unique in-plane anisotropic properties of the 2D alloyed nanosheets were found with the help of X-ray diffraction, high resolution transmission electron microscopy and polarized Raman spectroscopy. Moreover, 2D alloyed field-effect transistors were fabricated, exhibiting a unipolar p-type semiconductor behavior...
May 1, 2018: Nanoscale
Jae Hoon Jeong, Ji Suk Chang, Young-Hwan Jo
Release of fatty acids from lipid droplets upon activation of the sympathetic nervous system (SNS) is a key step in nonshivering thermogenesis in brown adipose tissue (BAT). However, intracellular lipolysis appears not to be critical for cold-induced thermogenesis. As activation of the SNS increases glucose uptake, we studied whether intracellular glycolysis plays a role in BAT thermogenesis. To stimulate BAT-innervating sympathetic nerves in vivo, we expressed channelrhodopsin-2 (ChR2) in catecholaminergic fibers by crossbreeding tyrosine hydroxylase-Cre mice with floxed-stop ChR2 mice...
April 27, 2018: Scientific Reports
Hui-Jie Fan, Ze-Ping Xie, Zi-Wen Lu, Zhang-Bin Tan, Yi-Ming Bi, Ling-Peng Xie, Yu-Ting Wu, Wen-Tong Zhang, Kevin Liu-Kot, Bin Liu, Ying-Chun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Si-Ni-San (SNS) is a well-known decoction in traditional Chinese medicine. Although studies have indicated that the anti-inflammatory and anti-allergic properties of SNS and its components can account for their therapeutic effects, the role and mechanism of SNS in treating skin dysfunction remain unclear. AIM OF THE STUDY: Atopic dermatitis (AD), a disorder known for its prevalence in infants and adults, severely influences the quality of life of affected patients...
April 23, 2018: Journal of Ethnopharmacology
G H KleinJan, E van Werkhoven, N S van den Berg, M B Karakullukcu, H J M A A Zijlmans, J A van der Hage, B A van de Wiel, T Buckle, W M C Klop, S Horenblas, R A Valdés Olmos, H G van der Poel, F W B van Leeuwen
PURPOSE: Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how fluorescence-guidance can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of the hybrid tracer indocyanine green (ICG)-99m Tc-nancolloid was evaluated in a large cohort of patients. PATIENTS AND METHODS: A prospective trial was conducted (n = 501 procedures) in a heterogeneous cohort of 495 patients with different malignancies (skin malignancies, oral cavity cancer, penile cancer, prostate cancer and vulva cancer)...
April 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
J Duelund-Jakobsen, S Laurberg, L Lundby
AIM: Sacral nerve stimulation has been recognized as an effective treatment option for faecal incontinence when conservative therapy has failed. Refinement of the procedural technique and the use of a curved stylet may improve the functional outcome. Our aim was to explore the relationship between lead model, functional outcome, stimulation amplitude and the need for extra visits during the first year of follow-up. METHOD: Patient data from May 2009 to February 2017, which were prospectively collected in a local database, were extracted and analysed for differences between lead model and improvement in incontinence scores, stimulation amplitude and the need for additional visits during the first year of follow-up...
April 25, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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