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https://www.readbyqxmd.com/read/28716208/spatial-dynamics-of-porcine-epidemic-diarrhea-ped-spread-in-the-southern-kyushu-japan
#1
Yosuke Sasaki, Haruya Toyomaki, Satoshi Sekiguchi, Masuo Sueyoshi, Kohei Makita, Satoshi Otake, Andres Perez, Julio Alvarez
Porcine epidemic diarrhea (PED) was detected for the first time in seven years in Japan in October 2013 in Okinawa Prefecture. By December 2013, PED had spread into Miyazaki and Kagoshima Prefectures in the southern part of Kyushu, one of the regions with the highest farm density in the country. The objective of the study here was to assess the spatial dynamics of PED spread during the 8 months of the epidemic in the southern part of Kyushu between December 2013, the month observed first case in the studied region, and July 2014...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28714807/structural-analysis-spectroscopic-characterization-and-molecular-docking-studies-of-the-cyclic-heptapeptide
#2
Sefa Celik, Serda Kecel-Gunduz, Sevim Akyuz, Aysen E Ozel
The theoretically possible stable conformer of the cyclic heptapeptide, that has significant anti-metastatic activity, was examined by conformational analysis followed by DFT calculations. Experimental infrared and Raman spectroscopy, together with theoretical DFT (6-31G (d,p) basis set)-based quantum chemical calculations, have been used to understand the structural and spectral characteristics of cyclo(Gly-Arg-Gly-Asp-Ser-Pro-Ala) {cyclo(GRGDSPA)}. A complete analysis of the vibrational spectrum has been reported on the basis of potential energy distribution (PED %) data of the vibrational modes...
July 17, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28712897/safety-and-efficacy-of-a-600mg-loading-dose-of-clopidogrel-24-hours-before-pipeline-embolization-device-treatment
#3
Elias Atallah, Hassan Saad, Kimon Bekelis, Nohra Chalouhi, Stavropoula Tjoumakaris, David Hasan, Hekmat Zarzour, Michelle Smith, Robert H Rosenwasser, Pascal Jabbour
BACKGROUND: Clopidogrel/aspirin antiplatelet therapy is routinely administered 7 to 10 days prior to pipeline aneurysm treatment. Our study assessed the safety and efficacy of a 600mg loading dose of clopidogrel 24 hours before PED treatment. METHODS: We performed a retrospective cohort study involving patients treated with pipeline from October 2010 to May 2016. 39.7%(n=158) patients were dispensed a loading dose of 650mg of aspirin plus at least 600mg of clopidogrel 24 hours preceding PED deployment; 60...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28710081/use-of-a-next-generation-multi-durometer-long-guide-sheath-for-triaxial-access-in-flow-diversion-experience-in-95-consecutive-cases
#4
Li-Mei Lin, Matthew T Bender, Geoffrey P Colby, Narlin B Beaty, Bowen Jiang, Jessica K Campos, Judy Huang, Rafael J Tamargo, Alexander L Coon
BACKGROUND: Intracranial access techniques in modern neurointerventions have shifted towards more robust access platforms. The long guide sheath is one of the building blocks of triaxial systems used in intracranial embolizations. Here we present our experience with the AXS Infinity LS long sheath in the triaxial platform for the implantation of the Pipeline embolization device (PED). METHODS: We retrospectively identified patients who underwent PED Flex treatment with the AXS Infinity LS at a single institution...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28708210/particle-image-velocimetry-tests-on-pediatric-45-cc-and-30-cc-ventricle-assist-devices-effects-of-heart-rate-on-vad-operation
#5
Dariusz Witkowski, Damian Obidowski, Piotr Reorowicz, Daniel Jodko, Krzysztof Jozwik
BACKGROUND: This study investigated flow analysis inside pediatric ventricle assist devices (VADs) designed and manufactured at the Foundation for Cardiac Surgery Development (FRK), Zabrze, Poland. The main goal of the experiment was to define the minimal heart rate admissible in clinical practice. METHODS: The flow was directed by mechanical, single-disc valves developed at the Lodz University of Technology, Institute of Turbomachinery in Lodz, Poland. VAD operation conditions under different heart rates were analyzed...
July 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28697618/evaluation-of-a-zulu-translation-of-the-parents-evaluation-of-developmental-status
#6
Maria Van der Merwe, Marlé Cilliers, Celesté Maré, Jeannie Van der Linde, Mia Le Roux
BACKGROUND: One of the greatest challenges in early communication intervention in South Africa is developing and implementing successful identification strategies in primary health care (PHC). A shortage of trained PHC personnel is one of the barriers to providing adequate health services in South Africa. This dearth of services creates the need to substitute clinician-administered developmental screening tools with parent-administered tools. AIM: To determine the accuracy of the Zulu Parents' Evaluation of Developmental Status (PEDS) in comparison with the outcome of the English PEDS...
June 28, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28697159/outpatient-parenteral-antimicrobial-therapy-and-judicious-use-of-pediatric-emergency-resources
#7
Michael Xu, Quynh Doan
BACKGROUND: Pediatric returns to the emergency department (RTED) vary between 3% and 13% of the total ED volume of visits. However, the incidence and contribution of scheduled RTED on pediatric emergency department (PED) utilization is less clear. Antimicrobial stewardship programs on inpatient wards have been shown to improve judicious use of outpatient parenteral antimicrobial therapy (OPAT) in upon discharge. The implementation of such programs in PEDs has yet to be reported. The objectives of this study are to quantify the burden of scheduled RTED for OPAT on PED utilization and to examine how frequently OPAT use are supported by published practice standards for 3 common pediatric infections-cellulitis, pneumonia, and urinary tract infections...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28693308/isolation-and-characterization-of-a-new-porcine-epidemic-diarrhea-virus-variant-that-occurred-in-korea-in-2014
#8
Dong-Kun Yang, Ha-Hyun Kim, Seong-Hun Lee, Soon-Seek Yoon, Joong-Won Park, In-Soo Cho
Porcine epidemic diarrhea (PED) has caused significant economic losses in the swine industry, and another epidemic occurred recently in Korea in 2014. Isolating and culturing the PED virus (PEDV) allow investigations into its pathogenesis and development of vaccines and diagnostic assays. In this study, we successfully isolated two PEDV isolates (QIAP1401 and QIAP1402) from naturally infected piglets in Jeju-do. Viral propagation was confirmed in Vero cells according to cytopathic effects, immunofluorescence assay, reverse transcription-polymerase chain reaction and electron microscopic analyses...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28692909/pipeline-embolization-of-posterior-communicating-artery-aneurysms-associated-with-a-fetal-origin-posterior-cerebral-artery
#9
Adam N Wallace, Yasha Kayan, Matthew J Austin, Josser E Delgado Almandoz, Mudassar Kamran, DeWitte T Cross, Christopher J Moran, Joshua W Osbun, Akash P Kansagra
BACKGROUND AND PURPOSE: Flow diversion may have advantages in the treatment of posterior communicating artery (PComA) aneurysms associated with a fetal origin posterior cerebral artery (PCA), which can be challenging to treat with conventional techniques. However, a PComA incorporated into the aneurysm may prevent or delay aneurysm occlusion. Also, coverage of a fetal origin PCA risks infarction of a large vascular territory. The purpose of this study was to examine the safety and effectiveness of using the Pipeline Embolization Device (PED) to treat PComA aneurysms associated with a fetal origin PCA...
June 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28692169/the-relationship-between-anxiety-and-quality-of-life-in-children-with-hereditary-angioedema
#10
Aharon Kessel, Henriette Farkas, Shmuel Kivity, Nóra Veszeli, Kinga Viktória Kőhalmi, Batya Engel-Yeger
BACKGROUND: The severe life-threatening characteristics of hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) can affect anxiety levels among pediatric patients. This emotional burden together with the physical restrictions of C1-INH-HAE may decrease children's health-related quality of life (HRQoL). OBJECTIVE: (1) To compare anxiety state and trait between children with C1-INH-HAE and healthy controls (2) To examine the relationship between the level of anxiety of children with C1-INH-HAE, their disease activity/affected sites and their HRQoL (3) To predict the HRQoL of children with C1-INH-HAE based on their anxiety level and disease activity/affected sites...
July 10, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28689198/influence-of-the-method-of-definition-on-the-prevalence-of-left-ventricular-hypertrophy-in-children-with-chronic-kidney-disease-data-from-the-know-ped-ckd-study
#11
Heeyeon Cho, Hyun Jin Choi, Hee Gyung Kang, Il-Soo Ha, Hae Il Cheong, Kyung Hee Han, Seong Heon Kim, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Young Seo Park
BACKGROUND/AIMS: Children with chronic kidney disease (CKD) have a high risk of cardiovascular disease. Left-ventricular (LV) hypertrophy (LVH) is an early marker of cardiovascular disease in pediatric CKD, and the prevalence of LVH in pediatric CKD is approximately 20-30% in pre-dialysis CKD patients. However, there is no consensus on the ideal method of defining LVH in pediatric CKD patients. Previous studies have typically used the LV mass index (LVMI), which is calculated as LV mass in grams divided by height in meters to the 2...
July 7, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28689075/anharmonic-vibrational-spectra-and-mode-mode-couplings-analysis-of-2-aminopyridine
#12
Mohd Faizan, Mohammad Jane Alam, Ziya Afroz, Sheeraz Ahmad Bhat, Shabbir Ahmad
Vibrational spectra of 2-aminopyridine (2AP) have been analyzed using the vibrational self-consistence field theory (VSCF), correlated corrected vibrational self-consistence field theory (CC-VSCF) and vibrational perturbation theory (VPT2) at B3LYP/6-311G(d,p) framework. The mode-mode couplings affect the vibrational frequencies and intensities. The coupling integrals between pairs of normal modes have been obtained on the basis of quartic force field (2MR-QFF) approximation. The overtone and combination bands are also assigned in the FTIR spectrum with the help of anharmonic calculation at VPT2 method...
July 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28684708/porcine-epidemic-diarrhea-in-europe-in-detail-analyses-of-disease-dynamics-and-molecular-epidemiology
#13
Dennis Hanke, Anne Pohlmann, Carola Sauter-Louis, Dirk Höper, Julia Stadler, Mathias Ritzmann, Adi Steinrigl, Bernd-Andreas Schwarz, Valerij Akimkin, Robert Fux, Sandra Blome, Martin Beer
Porcine epidemic diarrhea (PED) is an acute and highly contagious enteric disease of swine caused by the eponymous virus (PEDV) which belongs to the genus Alphacoronavirus within the Coronaviridae virus family. Following the disastrous outbreaks in Asia and the United States, PEDV has been detected also in Europe. In order to better understand the overall situation, the molecular epidemiology, and factors that might influence the most variable disease impact; 40 samples from swine feces were collected from different PED outbreaks in Germany and other European countries and sequenced by shot-gun next-generation sequencing...
July 6, 2017: Viruses
https://www.readbyqxmd.com/read/28683954/impact-of-porcine-epidemic-diarrhea-on-herd-and-individual-berkshire-sow-productivity
#14
Aina Furutani, Tadahiro Kawabata, Masuo Sueyoshi, Yosuke Sasaki
Porcine epidemic diarrhea (PED) is an emerging disease of pigs in several countries. In the present study, individual sow productivity of Berkshire sows exposed to PED virus at different stages of production was compared. On a commercial farrow-to-finish farm in Kagoshima Prefecture, Japan, the clinical presence of PED was observed in the farrowing barn on January 6, 2014, and all gilts and sows were immunized on January 9, except those in the farrowing barn. The sows were categorized into six groups based on the period in which they were exposed to PED virus: between days 0-30 (G1), 31-60 (G2), 61-90 (G3), or after 91 days of pregnancy (G4), during lactation (L), and after weaning (W)...
June 26, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28676778/children-s-first-experience-of-taking-anabolic-androgenic-steroids-can-occur-before-their-10th-birthday-a-systematic-review-identifying-9-factors-that-predicted-doping-among-young-people
#15
Adam R Nicholls, Ed Cope, Richard Bailey, Katrin Koenen, Detlef Dumon, Nikolaos C Theodorou, Benoit Chanal, Delphine Saint Laurent, David Müller, Mar P Andrés, Annemarie H Kristensen, Mark A Thompson, Wolfgang Baumann, Jean-Francois Laurent
Taking performance-enhancing drugs (PEDs) can cause serious and irreversible health consequences, which can ultimately lead to premature death. Some young people may take PEDs without fully understanding the ramifications of their actions or based on the advice from others. The purpose of this systematic review was to identify the main factors that predicted doping among young people. The literature was systematically reviewed using search engines, manually searching specialist journals, and pearl growing. Fifty-two studies, which included 187,288 young people aged between 10 and 21 years of age, 883 parents of adolescent athletes, and 11 adult coaches, who were interviewed regarding young athletes, were included in this review...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28669694/epidemiology-of-preoperative-hematologic-assessment-of-children-cared-for-in-a-pediatric-emergency-department
#16
Christopher Woll, P Brian Smith, James Walter Fox
OBJECTIVE: To assess frequency of preoperative hematologic testing in a tertiary care pediatric emergency department (PED) and how often these values predict clinical outcome or change management decisions. METHODS: Single-center retrospective cohort study in a tertiary-care children's hospital PED. Patients 0-18years old, presenting between July 1, 2009-July 1, 2011, ultimately undergoing a surgical procedure within 48h of presentation were included. Patients were defined as having "preoperative" hematologic assessment if these studies were performed solely because the child was going to the operative suite...
June 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28669089/patient-experience-in-the-pediatric-emergency-department-do-parents-and-children-feel-the-same
#17
Cristina Parra, Nereida Vidiella, Irene Marin, Victoria Trenchs, Carles Luaces
The objectives are to describe the experience of children and parents in a pediatric emergency service (PED) and to determine whether there are differences of opinion between the two groups. This was a descriptive study. A questionnaire was designed based on the Picker questionnaire on the patient experience. From July through December 2015, a survey was made of the children aged 8-18 treated in the PED, as well as of their parents. The proportion of dissatisfaction was determined. A total of 514 questionnaires (257 children, 257 parents) were completed...
July 1, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28667378/perturbation-of-hydrogen-bonding-in-hydrated-pyrrole-2-carboxaldehyde-complexes
#18
Meenakshi Rana, Papia Chowdhury
The interaction of external water molecules with hydrated pyrrole-2-carboxaldehyde PCL/(H2O) n complexes was investigated. The work was supported by both theoretical [DFT/TD-DFT methods using 6-311G++(d,p) basis set in the ground (S0) and excited (S1, S2, S3)states] and experimental [UV-Vis, FTIR and Raman] verification. The focus of the present work was on the weak intermolecular O-H⋯O, N-H⋯O-H hydrogen bonded interaction (IerHB) between PCL and external water molecules, and the influence of increasing the number of water molecules to form hydrated PCL/(H2O)n complexes...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28655307/short-term-efficacy-of-intravitreal-aflibercept-injections-for-retinal-angiomatous-proliferation
#19
Hung-Da Chou, Wei-Chi Wu, Nan-Kai Wang, Lan-Hsin Chuang, Kuan-Jen Chen, Chi-Chun Lai
BACKGROUND: To evaluate the short-term efficacy of intravitreal injections of aflibercept (IVA) to treat retinal angiomatous proliferation (RAP) and identify factors related to functional outcomes. METHODS: This retrospective case series consisted of 19 eyes in 19 patients with RAP. All 19 eyes received 3 monthly consecutive IVA. The primary outcome measures were best-corrected visual acuity (BCVA) and central retinal thickness (CRT) after the last IVA. RESULTS: Of the 19 treated eyes, 8 (42%) were pre-treated with 1 dose of bevacizumab one month prior to the initiation of treatment with aflibercept...
June 27, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28645675/anatomical-considerations-of-the-iliac-crest-on-percutaneous-endoscopic-discectomy-using-a-transforaminal-approach
#20
Fumitake Tezuka, Toshinori Sakai, Mitsunobu Abe, Kazuta Yamashita, Yoichiro Takata, Kosaku Higashino, Akihiro Nagamachi, Takashi Chikawa, Koichi Sairyo
BACKGROUND CONTEXT: Percutaneous endoscopic discectomy (PED) is a minimally invasive procedure for the surgical treatment of lumbar disc herniation (LDH). It can be performed under local anesthesia and requires a skin incision of only 8 mm, with minimal disruption of the spinal structures including ligaments and muscles. However, performing PED with a transforaminal approach (TF-PED) for the lower lumbar spine is associated with some anatomical problems such as interference from the iliac crest...
June 20, 2017: Spine Journal: Official Journal of the North American Spine Society
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