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https://www.readbyqxmd.com/read/28813577/spatial-correspondence-between-intraretinal-fluid-subretinal-fluid-and-pigment-epithelial-detachment-in-neovascular-age-related-macular-degeneration
#1
Sophie Klimscha, Sebastian M Waldstein, Thomas Schlegl, Hrvoje Bogunovic, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Eleonore Pablik, Li Zhang, Michael D Abramoff, Milan Sonka, Bianca S Gerendas, Ursula Schmidt-Erfurth
Purpose: To identify the spatial distribution of exudative features of choroidal neovascularization in neovascular age-related macular degeneration (nAMD) based on the localization of intraretinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment-epithelial detachment (PED). Methods: This retrospective cross-sectional study included spectral-domain optical coherence tomography volume scans (6 × 6 mm) of 1341 patients with treatment-naïve nAMD. IRC, SRF, and PED were detected on a per-voxel basis using fully automated segmentation algorithms...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28808073/unintentional-cannabis-intoxication-in-toddlers
#2
Isabelle Claudet, Sébastien Mouvier, Magali Labadie, Cécile Manin, Anne-Pascale Michard-Lenoir, Didier Eyer, Damien Dufour
BACKGROUND AND OBJECTIVES: In France, cannabis consumption is illegal. The health impact of its increasing use and higher tetrahydrocannabinol (THC) concentrations is still poorly documented, particularly that of unintentional pediatric intoxications. We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (2004-2014). METHODS: A retrospective, national, multicenter, observational study of a pediatric cohort...
August 14, 2017: Pediatrics
https://www.readbyqxmd.com/read/28762959/mechanical-properties-and-cell-culture-characteristics-of-polycaprolactone-kagome-structure-scaffold-fabricated-by-precision-extruding-deposition-system
#3
Se-Hwan Lee, Yong Sang Cho, Myoung Wha Hong, Bu Kyu Lee, Yong-Doo Park, Sang-Hyug Park, Young-Yul Kim, Young-Sam Cho
To date, to enhance the mechanical properties of three-dimensional scaffolds used for bone regeneration in tissue engineering, many researchers have tried in the viewpoint of structure and chemistry. Meanwhile, in the structural engineering field, the kagome structure has been known as an excellent relative strength. In this study, to enhance the mechanical properties of a synthetic polymer scaffold used for tissue engineering, we applied the three-dimensional kagome structure to a porous scaffold for bone regeneration...
August 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28759264/breastfeeding-education-and-support-services-provided-to-family-medicine-and-obstetrics-gynecology-residents
#4
Elizabeth Rodriguez Lien, Karen Shattuck
BACKGROUND: Breastfeeding education is known to be insufficient in pediatric (PEDS) training and is, in part, responsible for suboptimal rates of breastfeeding. No recent studies about the level of education provided to family medicine (FM) and obstetrics-gynecology (OB) residency trainees are available. OBJECTIVES: This study was conducted to investigate breastfeeding education and support services provided to FM and OB residents in the United States. The results were compared with a 2011 study of PEDS residents...
July 31, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28758549/pipeline-embolization-device-retraction-and-foreshortening-after-internal-carotid-artery-blister-aneurysm-treatment
#5
Jeremy J Heit, Nicholas A Telischak, Huy M Do, Robert L Dodd, Gary K Steinberg, Michael P Marks
Background Subarachnoid hemorrhage (SAH) secondary to rupture of a blister aneurysm (BA) results in high morbidity and mortality. Endovascular treatment with the pipeline embolization device (PED) has been described as a new treatment strategy for these lesions. We present the first reported case of PED retraction and foreshortening after treatment of a ruptured internal carotid artery (ICA) BA. Case description A middle-aged patient presented with SAH secondary to ICA BA rupture. The patient was treated with telescoping PED placement across the BA...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28758349/appearance-of-us-like-porcine-epidemic-diarrhoea-virus-pedv-strains-before-us-outbreaks-and-genetic-heterogeneity-of-pedvs-collected-in-northern-vietnam-during-2012-2015
#6
N V Diep, M Sueyoshi, U Izzati, N Fuke, A P P Teh, N T Lan, R Yamaguchi
Porcine epidemic diarrhoea virus (PEDV) is the aetiologic agent of porcine epidemic diarrhoea (PED), a highly contagious enteric disease that is threatening the swine industry globally. Since PED was first reported in Southern Vietnam in 2009, the disease has spread throughout the country and caused substantial economic losses. To identify PEDVs responsible for the recent outbreaks, the full-length spike (S) gene of 25 field PEDV strains collected from seven northern provinces of Vietnam was sequenced and analysed...
July 30, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28756261/spectroscopic-and-dft-studies-of-bis-3-hydroxypyridinium-and-bis-3-hydroxymethylpyridinium-dibromides-with-tetramethylene-linker
#7
Anna Komasa
Experimental and theoretical IR, Raman, UV-Vis, (1)H and (13)C NMR spectra of 1,4-di(3-hydroxypyridinium)butane dibromide and 1,4-di(3-hydroxymethylpyridinium)butane dibromide were obtained and analyzed. Optimized geometrical structures of the studied compounds were calculated by B3LYP method using 6-311++G(d,p) basis set and employed to determine the theoretical wavenumbers and intensities of IR and Raman spectra. The frequency assignments were supported by the potential energy distribution (PED) analysis...
July 22, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28756260/molecular-structures-spectroscopic-ft-ir-nmr-uv-studies-nbo-analysis-and-nlo-properties-for-tautomeric-forms-of-1-3-dimethyl-5-phenylazo-6-aminouracil-by-density-functional-method
#8
Aslı Eşme, Seda Güneşdoğdu Sağdınç
The equilibrium geometry, nuclear magnetic resonance (NMR) and UV-Vis analysis, and vibrational frequencies for the azo and hydrazone isomers of 1,3-dimethyl-5-(phenylazo)-6-aminouracil have been performed using density functional theory (DFT/B3LYP) method with 6-311G(d,p) basis set. A detailed interpretation of the vibrational spectra has been made on the basis of the calculated potential energy distribution (PED) obtained from the Vibrational Energy Distribution Analysis (VEDA4) program. The (1)H NMR chemical shifts with respect to TMS were calculated by the gauge independent atomic orbital (GIAO) method and compared with the experimental data...
July 24, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28756257/quantum-mechanical-and-spectroscopic-ft-ir-ft-raman-study-nbo-analysis-homo-lumo-first-order-hyperpolarizability-and-molecular-docking-study-of-methyl-3r-3-2-methylphenoxy-3-phenylpropyl-amine-by-density-functional-method
#9
Tintu K Kuruvilla, Johanan Christian Prasana, S Muthu, Jacob George, Sheril Ann Mathew
Quantum chemical techniques such as density functional theory (DFT) have become a powerful tool in the investigation of the molecular structure and vibrational spectrum and are finding increasing use in application related to biological systems. The Fourier transform infrared (FT-IR) and Fourier transform Raman (FT-Raman) techniques are employed to characterize the title compound. The vibrational frequencies were obtained by DFT/B3LYP calculations with 6-31G(d,p) and 6-311++G(d,p) as basis sets. The geometry of the title compound was optimized...
July 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28755162/coexistence-of-multiple-genotypes-of-porcine-epidemic-diarrhea-virus-with-novel-mutant-s-genes-in-the-hubei-province-of-china-in-2016
#10
Zhe Zeng, Ting-Ting Li, Xin Jin, Fu-Hu Peng, Nian-Hua Song, Gui-Qing Peng, Xing-Yi Ge
The emergence of highly virulent porcine epidemic diarrhea virus (PEDV) variants in China caused huge economic losses in 2010. Since then, large-scale sporadic outbreaks of PED caused by PEDV variants have occasionally occurred in China. However, the molecular diversity and epidemiology of PEDV in different provinces has not been completely understood. To determine the molecular diversity of PEDV in the Hubei Province of China, we collected 172 PED samples from 34 farms across the province in 2016 and performed reverse transcription polymerase chain reaction (RTPCR) by targeting the nucleocapsid (N) gene...
July 26, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28748748/outcome-study-of-the-pipeline-embolization-device-for-treatment-of-intracranial-aneurysms-at-a-single-uk-institution
#11
Shih-Hung Yang, Timothy Hampton, Naga Kandasamy, Jonathan Hart, Jonathan Ashmore, Daniel C Walsh, Christos M Tolias, Thomas C Booth
BACKGROUND: The introduction of flow-diverting stents in the last decade provides an alternative endovascular treatment choice in selected intracranial aneurysms. This retrospective analysis of a UK centre's experience provides insight into clinical and radiographic outcomes. METHODS: Electronic patient records, diagnostic and procedural images and written procedural records for patients treated with the PED between August 2009 and April 2014 were reviewed. Follow-up TOF MRA was performed after treatment...
July 27, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28734810/retinal-pigment-epithelium-humps-in-high-myopia
#12
Alessandro Marchese, Adriano Carnevali, Riccardo Sacconi, Teresa Centoducati, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To report on the presence of retinal pigment epithelium (RPE) humps in high myopia, and to describe the distinctive features from pathological PEDs and choroidal neovascularizations (CNVs). DESIGN: Retrospective cross-sectional study. METHODS: Charts and imaging studies of highly myopic patients presenting between September 2015 and February 2017 at a university teaching hospital were consecutively reviewed. All patients underwent spectral domain optical coherence tomography (OCT)...
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28731052/real-world-visual-acuity-outcomes-between-ranibizumab-and-aflibercept-in-treatment-of-neovascular-amd-in-a-large-us-data-set
#13
A Lotery, R Griner, A Ferreira, F Milnes, P Dugel
PurposeTo examine 12-month real-world visual acuity outcomes and treatment patterns in neovascular age-related macular degeneration (nAMD) eyes, including those with pigment epithelial detachment (PED), receiving ranibizumab or aflibercept.Patients and methodsElectronic medical records were used to identify ranibizumab or aflibercept-treated nAMD eyes with 12 months follow-up from first prescription. The primary objective was to compare mean change in visual acuity (VA) between index and month 12, in eyes treated with ranibizumab and aflibercept to assess the non-inferiority of ranibizumab vs aflibercept using a -5 letter non-inferiority margin...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28729948/algorithms-for-the-automated-analysis-of-age-related-macular-degeneration-biomarkers-on-optical-coherence-tomography-a-systematic-review
#14
REVIEW
Maximilian W M Wintergerst, Thomas Schultz, Johannes Birtel, Alexander K Schuster, Norbert Pfeiffer, Steffen Schmitz-Valckenberg, Frank G Holz, Robert P Finger
PURPOSE: To assess the quality of optical coherence tomography (OCT) grading algorithms for retinal biomarkers of age-related macular degeneration (AMD). METHODS: Following a systematic review of the literature data on detection and quantification of AMD retinal biomarkers by available algorithms were extracted and descriptively synthesized. Algorithm quality was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies 2 checklist with a focus on accuracy against established reference standards and risk of bias...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28729946/decrease-in-short-latency-afferent-inhibition-during-corticomotor-postexercise-depression-following-repetitive-finger-movement
#15
Shota Miyaguchi, Sho Kojima, Ryoki Sasaki, Shinichi Kotan, Hikari Kirimoto, Hiroyuki Tamaki, Hideaki Onishi
INTRODUCTION: This study aimed to clarify cortical circuit mechanisms contributing to corticomotor excitability during postexercise depression (PED) following repetitive nonfatiguing movement. We investigated changes in short-latency afferent inhibition (SAI) and short-interval intracortical inhibition (SICI) by paired-pulse transcranial magnetic stimulation (TMS) during PED. METHODS: A total of 16 healthy subjects performed repetitive abduction movements of the right index finger at 2...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28724829/case-report-of-a-secondary-macular-hole-closure-after-intravitreal-bevacizumab-therapy-in-a-patient-with-retinal-pigment-epithelial-detachment
#16
Marcus Werner Storch, Hans Hoerauf
We describe a case of macular hole (MH) closure after intravitreal bevacizumab therapy for an underlying pigment epithelial detachment (PED) due to exudative age-related macular degeneration (AMD). The 73-year-old Caucasian female presented with reduced visual acuity (20/80) of the left eye and metamorphopsia for approximately 6 months. Spectral domain optical coherence tomography revealed a subfoveal PED due to AMD with an associated MH. To treat the exudative component of the pathology, we started intravitreal bevacizumab therapy, consecutively leading to reduction of the height of PED and allowing closure of the MH...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28723848/progression-of-macular-atrophy-in-eyes-with-type-1-neovascularization-and-age-related-macular-degeneration-receiving-long-term-intravitreal-anti-vascular-endothelial-growth-factor-therapy-an-optical-coherence-tomographic-angiography-analysis
#17
Joseph G Christenbury, Nopasak Phasukkijwatana, Fatimah Gilani, K Baily Freund, SriniVas Sadda, David Sarraf
PURPOSE: To evaluate the size and location of macular atrophy in eyes with Type-1 neovascularization (NV) and age-related macular degeneration receiving chronic intravitreal anti-vascular endothelial growth factor therapy. METHODS: A retrospective review of a case series of 27 eyes with Type-1 NV and retinal pigment epithelial detachment (PED) having a minimum of 12 months follow-up was performed. Demographic information and visual acuity at baseline and the final follow-up were collected...
July 18, 2017: Retina
https://www.readbyqxmd.com/read/28716208/spatial-dynamics-of-porcine-epidemic-diarrhea-ped-spread-in-the-southern-kyushu-japan
#18
Yosuke Sasaki, Haruya Toyomaki, Satoshi Sekiguchi, Masuo Sueyoshi, Kohei Makita, Satoshi Otake, Andres Perez, Julio Alvarez
Porcine epidemic diarrhea (PED) was detected for the first time in seven years in Japan in October 2013 in Okinawa Prefecture. By December 2013, PED had spread into Miyazaki and Kagoshima Prefectures in the southern part of Kyushu, one of the regions with the highest farm density in the country. The objective of the study here was to assess the spatial dynamics of PED spread during the 8 months of the epidemic in the southern part of Kyushu between December 2013, the month observed first case in the studied region, and July 2014...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28714807/structural-analysis-spectroscopic-characterization-and-molecular-docking-studies-of-the-cyclic-heptapeptide
#19
Sefa Celik, Serda Kecel-Gunduz, Sevim Akyuz, Aysen E Ozel
The theoretically possible stable conformer of the cyclic heptapeptide, that has significant anti-metastatic activity, was examined by conformational analysis followed by DFT calculations. Experimental infrared and Raman spectroscopy, together with theoretical DFT (6-31G (d,p) basis set)-based quantum chemical calculations, have been used to understand the structural and spectral characteristics of cyclo(Gly-Arg-Gly-Asp-Ser-Pro-Ala) {cyclo(GRGDSPA)}. A complete analysis of the vibrational spectrum has been reported on the basis of potential energy distribution (PED%) data of the vibrational modes...
August 3, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28712897/safety-and-efficacy-of-a-600mg-loading-dose-of-clopidogrel-24-hours-before-pipeline-embolization-device-treatment
#20
Elias Atallah, Hassan Saad, Kimon Bekelis, Nohra Chalouhi, Stavropoula Tjoumakaris, David Hasan, Hekmat Zarzour, Michelle Smith, Robert H Rosenwasser, Pascal Jabbour
BACKGROUND: Clopidogrel/aspirin antiplatelet therapy is routinely administered 7 to 10 days prior to pipeline aneurysm treatment. Our study assessed the safety and efficacy of a 600mg loading dose of clopidogrel 24 hours before PED treatment. METHODS: We performed a retrospective cohort study involving patients treated with pipeline from October 2010 to May 2016. 39.7%(n=158) patients were dispensed a loading dose of 650mg of aspirin plus at least 600mg of clopidogrel 24 hours preceding PED deployment; 60...
July 13, 2017: World Neurosurgery
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