keyword
MENU ▼
Read by QxMD icon Read
search

alcohol related diseases

keyword
https://www.readbyqxmd.com/read/29333614/the-effect-of-risk-factor-misclassification-on-the-partial-population-attributable-risk
#1
Benedict H W Wong, Sarah B Peskoe, Donna Spiegelman
The partial population attributable risk (pPAR) is used to quantify the population-level impact of preventive interventions in a multifactorial disease setting. In this paper, we consider the effect of nondifferential risk factor misclassification on the direction and magnitude of bias of pPAR estimands and related quantities. We found that the bias in the uncorrected pPAR depends nonlinearly and nonmonotonically on the sensitivities, specificities, relative risks, and joint prevalence of the exposure of interest and background risk factors, as well as the associations between these factors...
January 15, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29331492/prognostic-value-of-the-expression-of-dna-repair-related-biomarkers-mediated-by-alcohol-in-gastric-cancer-patients
#2
Yiyin Zhang, Hongyang Wu, Feng Yang, Jie Ning, Min Li, Chenchen Zhao, Shuping Zhong, Kangsheng Gu, Hua Wang
Alcohol consumption likely induces gastric carcinogenesis through deregulation of RNA polymerase (Pol) III genes and oxidative damage. Transcription factor IIB-related factor 1 (BRF1) overexpression alleviates RNA Pol III transcription inhibition through breast cancer susceptibility gene 1 (BRCA1). Myeloperoxidase (MPO) involvement in cancer is induced by alcohol-mediated oxidative damage. BRCA1/2 and MPO play key roles in DNA repair. BRCA1 and BRCA2 exert different roles in homologous recombination repair...
January 5, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29330687/evaluation-of-the-mitochondria-related-redox-and-bioenergetics-effects-of-gastrodin-in-sh-sy5y-cells-exposed-to-hydrogen-peroxide
#3
Marcos Roberto de Oliveira, Flávia Bittencourt Brasil, Cristina Ribas Fürstenau
Mitochondrion is the main site of ATP production in animal cells and also orchestrates signaling pathways associated with cell survival and death. Mitochondrial dysfunction has been linked to bioenergetics and redox impairment in human diseases, such as neurodegeneration and cardiovascular disease. Protective agents able to attenuate mitochondrial impairment are of pharmacological interest. Gastrodin (GAS; 4-hydroxybenzyl alcohol 4-O-beta-D-glucoside) is a phenolic glucoside obtained from the Chinese herbal medicine Gastrodia elata Blume and exhibits antioxidant, anti-inflammatory, and antiapoptotic effects in several cell types...
January 12, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29330220/regulation-of-drug-metabolism-by-the-interplay-of-inflammatory-signaling-steatosis-and-xeno-sensing-receptors-in-heparg-cells
#4
Norman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M Zanger, Linda Bohmert, Alfonso Lampen, Albert Braeuning
Non-alcoholic fatty liver disease (NAFLD), characterized by triglyceride deposition in hepatocytes due to imbalanced lipid homeostasis, is of increasing concern in Western countries, with progression to non-alcoholic steatohepatitis (NASH), liver fibrosis, and cirrhosis. Previous studies suggest a complex, mutual influence of hepatic fat accumulation, NASH-related inflammatory mediators, and drug-sensing receptors regulating xenobiotic metabolism. Here, we investigated the suitability of human HepaRG hepatocarcinoma cells as a model for NAFLD and NASH...
January 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29330031/mental-health-disorders-mediate-association-of-sexual-minority-identity-with-cardiovascular-disease
#5
Lezhou Wu, Randy L Sell, Alexis M Roth, Seth L Welles
BACKGROUND: Little is known about cardiovascular health disparities for lesbian, gay, or bisexual (LGB) persons and whether these disparities are mediated by mental health disorders due to sexual minority stress. We hypothesize LGB identity is associated with an increased risk of cardiovascular disease (CVD) and that major depressive disorder (MDD) and generalized anxiety disorders (GAD) may mediate this association. METHODS: The National Epidemiologic Survey on Alcohol and Related Conditions is a longitudinal, nationally-representative study of non-institutionalized U...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29329373/co-existing-hepatitis-c-and-alcoholic-liver-disease-a-diminishing-indication-for-liver-transplantation
#6
Amanda Wieland, Gregory T Everson
Aims: To provide an overview of published literature on the interaction of alcohol and hepatitis C virus (HCV) in the accelerated progression of liver disease to cirrhosis as relates to decision-making for the management of the liver transplant candidate and recipient. Methods: General PubMed search was employed along with expert input to identify the relevant articles on the topic. The authors also utilized both backward and forward citation review of the relevant articles and reviews to identify articles on identified topic...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29326427/severe-steatosis-induces-portal-hypertension-by-systemic-arterial-hyporeactivity-and-hepatic-vasoconstrictor-hyperreactivity-in-rats
#7
Denise Van der Graaff, Wilhelmus J Kwanten, Filip J Couturier, Jesse S Govaerts, Wim Verlinden, Isabel Brosius, Michiel D'Hondt, Ann Driessen, Benedicte Y De Winter, Joris G De Man, Peter P Michielsen, Sven M Francque
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease. The presence of portal hypertension has been demonstrated in NAFLD prior to development of inflammation or fibrosis, and is a result of extrahepatic and intrahepatic factors, principally driven by vascular dysfunction. An increased intrahepatic vascular resistance potentially contributes to progression of NAFLD via intralobular hypoxia. However, the exact mechanisms underlying vascular dysfunction in NAFLD remain unknown...
January 11, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29323715/alleviation-of-palmitic-acid-induced-endoplasmic-reticulum-stress-by-augmenter-of-liver-regeneration-through-ip3r-controlled-ca2-release
#8
Wei-Chun Xiao, Zhang Jing, Si-Li Chen, Yi-Jun Shi, Fan Xiao, Wei An
The aberrant release of Ca2+ from the endoplasmic reticulum (ER) contributes to the onset of ER stress, which is closely related to the pathogenesis of non-alcoholic fatty liver disease. We previously reported that augmenter of liver regeneration (ALR) alleviates ER stress and protects hepatocytes from lipotoxicity. However, the link between ALR protection and the suppression of ER stress remains unclear. In this study, we investigated whether the protection against liver steatosis afforded by ALR is related to its inhibition of calcium overflow from the ER to the mitochondria...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323248/exploring-the-utility-of-alcohol-flushing-as-an-instrumental-variable-for-alcohol-intake-in-koreans
#9
Yoonsu Cho, Soyoung Kwak, Sarah J Lewis, Kaitlin H Wade, Caroline L Relton, George Davey Smith, Min-Jeong Shin
Previous studies have indicated an association of higher alcohol intake with cardiovascular disease and related traits, but causation has not been definitively established. In this study, the causal effect of alcohol intake on hypertension in 2,011 men and women from the Ansan-Ansung cohort was estimated using an instrumental variable (IV) approach, with both a phenotypic and genotypic instrument for alcohol intake: alcohol flushing and the rs671 genotype (in the alcohol dehydrogenase 2 [ALDH2] gene), respectively...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319620/liver-transplantation-for-nash-related-hepatocellular-carcinoma-versus-non-nash-etiologies-of-hepatocellular-carcinoma
#10
Erin M Sadler, Neil Mehta, Mamatha Bhat, Anand Ghanekar, Paul D Greig, David R Grant, Francis Yao, Gonzalo Sapisochin
BACKGROUND: Liver Transplant (LT) for Non-Alcoholic Steatohepatitis (NASH) related Hepatocellular Carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) vs. HCC from other liver diseases (non-NASH). METHODS: Using a two-centre retrospective design all patients from 2004-2014 that received LT for HCC were analyzed. Subgroup analysis stratified patients according to Milan criteria...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29318932/decreased-taurine-and-creatine-in-the-thalamus-may-relate-to-behavioral-impairments-in-ethanol-fed-mice-a-pilot-study-of-proton-magnetic-resonance-spectroscopy
#11
Su Xu, Wenjun Zhu, Yamin Wan, JiaBei Wang, Xi Chen, Liya Pi, Mary Kay Lobo, Bin Ren, Zhekang Ying, Michael Morris, Qi Cao
Minimal hepatic encephalopathy (MHE) is highly prevalent, observed in up to 80% of patients with liver dysfunction. Minimal hepatic encephalopathy is defined as hepatic encephalopathy with cognitive deficits and no grossly evident neurologic abnormalities. Clinical management may be delayed due to the lack of in vivo quantitative methods needed to reveal changes in brain neurobiochemical biomarkers. To gain insight into the development of alcoholic liver disease-induced neurological dysfunction (NDF), a mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes in neurochemical levels in the thalamus and hippocampus that relate to behavioral changes...
January 2018: Molecular Imaging
https://www.readbyqxmd.com/read/29318691/trends-in-alcohol-related-mortality-in-east-and-west-germany-1980-to-2014-age-period-and-cohort-variations
#12
Daniela Piontek, Ludwig Kraus
BACKGROUND AND AIMS: Several indicators suggest that the extent and trends of alcohol-related mortality differ between East and West Germany. Regional drinking patterns and differences in health care systems are assumed to affect the risk of dying from an alcohol-induced disease. The study addresses two questions: (1) What are the unbiased and independent age, period, and cohort effects on alcohol-related mortality trends in Germany? (2) Do these trends differ between East and West Germany? METHODS: Data on alcohol-related mortality for East and West Germany came from the national causes of deaths register for the years 1980 to 2014...
January 10, 2018: Addiction
https://www.readbyqxmd.com/read/29317276/accuracy-of-the-enhanced-liver-fibrosis-test-vs-fibrotest-elastography-and-indirect-markers-in-detection-of-advanced-fibrosis-in-patients-with-alcoholic-liver-disease
#13
Maja Thiele, Bjørn Stæhr Madsen, Janne Fuglsang Hansen, Sönke Detlefsen, Steen Antonsen, Aleksander Krag
BACKGROUND & AIMS: Alcohol is the leading cause of cirrhosis and liver-related mortality, but we lack serum markers to detect compensated disease. We compared the accuracy of the Enhanced Liver Fibrosis test (ELF), the FibroTest, liver stiffness measurements (made by transient elastography and 2-dimensional shear-wave elastography), and 6 indirect marker tests in detection of advanced liver fibrosis (Kleiner stage ≥F3). METHODS: We performed a prospective study of 10 liver fibrosis markers (patented and not), all performed on the same day...
January 6, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29316565/transjugular-intrahepatic-portosystemic-shunt-in-patients-with-portal-hypertension-patency-depends-on-coverage-and-interventionalist-s-experience
#14
Matthias Buechter, Paul Manka, Guido Gerken, Ali Canbay, Sandra Blomeyer, Axel Wetter, Jens Altenbernd, Alisan Kahraman, Jens M Theysohn
BACKGROUND AND AIMS: Transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice in decompensated portal hypertension. TIPS revision due to thrombosis or stenosis increases morbidity and mortality. Our aim was to investigate patient- and procedure-associated risk factors for TIPS-revision. PATIENTS AND METHODS: We retrospectively evaluated 189 patients who underwent the TIPS procedure. Only patients who required TIPS revision within 1 year (Group I, 34 patients) and patients who did not require re-intervention within the first year (Group II [control group], 54 patients) were included...
January 9, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29315965/do-health-related-factors-predict-major-depression-a-longitudinal-epidemiologic-study
#15
Xiao Chi Zhang, Marcella L Woud, Eni S Becker, Jürgen Margraf
Major depressive disorder (MDD) is a leading cause of global disease burden. Hence, examining the role of risk and protective factors for MDD is an important target in psychological research. Various studies showed that obesity, smoking, and alcohol consumption are related to depressive symptoms. In contrast, physical activity has been found to be a protective factor. The present population-based study tested whether these health-related factors are prospectively associated with incidence of MDD. Data were taken from the Dresden Predictor Study, which was designed to investigate risk and protective factors of mental health in young women...
January 8, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29314571/relative-changes-in-handgrip-strength-and-skeletal-muscle-volume-in-patients-with-chronic-liver-disease-over-two-year-observation-period
#16
Atsushi Hiraoka, Kojiro Michitaka, Hirofumi Izumoto, Hidetaro Ueki, Shogo Kitahata, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Yuji Miyamoto, Ryuichiro Iwasaki, Hideomi Tomida, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Tomoyuki Ninomiya, Yoichi Hiasa
BACKGROUND/AIM: There are few reports regarding relative changes in muscle function of patients with chronic liver disease (CLD). We examined CLD patients to evaluate relative changes in handgrip strength and muscle volume. MATERIAL/METHODS: We enrolled 413 CLD outpatients who underwent handgrip strength measurements in both 2015 and 2017 [age 67.9±10.0 years, male/female=242/171, HCV/HBV/HBV&HCV/alcohol/others=239/92/4/22/56, Child-Pugh score (CPS) in 2017 (5/6/7/8/9/≥10=319/56/13/11/5/9)]...
January 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29312837/recreational-marijuana-use-and-acute-myocardial-infarction-insights-from-nationwide-inpatient-sample-in-the-united-states
#17
Rupak Desai, Upenkumar Patel, Shobhit Sharma, Parth Amin, Rushikkumar Bhuva, Malav S Patel, Nitin Sharma, Manan Shah, Smit Patel, Sejal Savani, Neha Batra, Gautam Kumar
Background Marijuana is a widely used recreational substance. Few cases have been reported of acute myocardial infarction following marijuana use. To our knowledge, this is the first ever study analyzing the lifetime odds of acute myocardial infarction (AMI) with marijuana use and the outcomes in AMI patients with versus without marijuana use. Methods We queried the 2010-2014 National Inpatient Sample (NIS) database for 11-70-year-old AMI patients. Pearson Chi-square test for categorical variables and Student T-test for continuous variables were used to compare the baseline demographic and hospital characteristics between two groups (without vs...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29312569/metformin-improves-nonalcoholic-fatty-liver-disease-in-obese-mice-via-down-regulation-of-apolipoprotein-a5-as-part-of-the-ampk-lxr%C3%AE-signaling-pathway
#18
Min-Jie Lin, Wen Dai, Melanie J Scott, Rong Li, Yi-Qi Zhang, Yang Yang, Lu-Zhu Chen, Xian-Sheng Huang
Apolipoprotein A5 (apoA5) has been implicated in the formation of hepatocyte lipid droplets, a histological hallmark of non-alcoholic fatty liver disease (NAFLD). Recent evidence demonstrated that liver X receptor α (LXRα), a transcription factor involved in down-regulation of APOA5 mRNA, is activated by AMP-activated protein kinase (AMPK) that contributes to metformin-related antihyperglycemic effects. In this study we investigated the role of apoA5 and AMPK/LXRα signaling pathway in metformin-related improvement of NAFLD...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310246/evaluation-of-metabolites-extraction-strategies-for-identifying-different-brain-regions-and-their-relationship-with-alcohol-preference-and-gender-difference-using-nmr-metabolomics
#19
Jie Wang, Hao-Long Zeng, Hongying Du, Zeyuan Liu, Ji Cheng, Taotao Liu, Ting Hu, Ghulam Mustafa Kamal, Xihai Li, Huili Liu, Fuqiang Xu
Metabolomics generate a profile of small molecules from cellular/tissue metabolism, which could directly reflect the mechanisms of complex networks of biochemical reactions. Traditional metabolomics methods, such as OPLS-DA, PLS-DA are mainly used for binary class discrimination. Multiple groups are always involved in the biological system, especially for brain research. Multiple brain regions are involved in the neuronal study of brain metabolic dysfunctions such as alcoholism, Alzheimer's disease, etc. In the current study, 10 different brain regions were utilized for comparative studies between alcohol preferring and non-preferring rats, male and female rats respectively...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29304750/lower-body-functioning-and-correlates-among-older-american-indians-the-cerebrovascular-disease-and-its-consequences-in-american-indians-study
#20
R Turner Goins, Mark Schure, Paul N Jensen, Astrid Suchy-Dicey, Lonnie Nelson, Steven P Verney, Barbara V Howard, Dedra Buchwald
BACKGROUND: More than six million American Indians live in the United States, and an estimated 1.6 million will be aged ≥65 years old by 2050 tripling in numbers since 2012. Physical functioning and related factors in this population are poorly understood. Our study aimed to assess lower body functioning and identify the prevalence and correlates of "good" functioning in a multi-tribe, community-based sample of older American Indians. METHODS: Assessments used the Short Physical Performance Battery (SPPB)...
January 5, 2018: BMC Geriatrics
keyword
keyword
44583
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"