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https://www.readbyqxmd.com/read/29792946/investigation-of-nonalcoholic-fatty-liver-disease-induced-drug-metabolism-by-comparative-global-toxicoproteomics
#1
Ann-Yae Na, Jung Jae Jo, Ok Kwang Kwon, Riya Shrestha, Piljoung Cho, Kyu Min Kim, Sung Hwan Ki, Tae Hee Lee, Tae Won Jeon, Tae Cheon Jeong, Sangkyu Lee
Non-alcoholic fatty liver disease (NAFLD) includes conditions such as steatosis, non-alcoholic steatohepatitis, and ultimately hepatocellular carcinoma. Although the pathology of NAFLD is well-established, NAFLD-induced drug metabolism mediated by cytochrome P450 (CYP) in the liver has remained largely unexplored. Therefore, we investigated NAFLD-induced drug metabolism mediated by CYP by quantitative toxicoproteomics analysis. After administration of a methionine-choline deficient (MCD) diet to induce development of NAFLD, tandem mass tags-based liquid chromatography-tandem mass spectrometry analysis was conducted to investigate the dynamics of hepatic proteins...
May 21, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29792024/metabotropic-glutamate-receptors-in-alcohol-use-disorder-physiology-plasticity-and-promising-pharmacotherapies
#2
Max E Joffe, Samuel W Centanni, Anel A Jaramillo, Danny G Winder, P Jeffrey Conn
Developing efficacious treatments for alcohol use disorder (AUD) has proven difficult. The insidious nature of the disease necessitates a deep understanding of its underlying biology as well as innovative approaches to ameliorate ethanol-related pathophysiology. Excessive ethanol-seeking and relapse are generated by long-term changes to membrane properties, synaptic physiology, and plasticity throughout the limbic system and associated brain structures. Each of these factors can be modulated by metabotropic glutamate (mGlu) receptors, a diverse set of G protein-coupled receptors highly expressed throughout the central nervous system...
May 23, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29791248/ddy-mice-fed-10-fat-diet-exhibit-high-p27kip-expression-and-delayed-hepatocyte-dna-synthesis-during-liver-regeneration
#3
Yohei Saito, Yoshikazu Kuwahara, Yumi Yamamoto, Masatoshi Suzuki, Manabu Fukumoto, Fumihiko Yamamoto
BACKGROUND: Excessive intake of a high-calorie diet has been implicated in the development of non-alcoholic fatty liver disease (NAFLD). Several studies have investigated the effect of NAFLD on liver regeneration, but the effects of simple steatosis have been found to be inconsistent. We aimed to assess whether the initial phase of diet-induced lipid accumulation, induced by a diet containing moderate levels of fat, impairs liver regeneration after partial hepatectomy (PHx) of mice. METHODS: Male ddY mice are prone to obesity, even when fed a relatively low-fat diet (FD)...
May 23, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29787859/design-and-rationale-of-the-insyte-study-a-randomised-placebo-controlled-study-to-test-the-efficacy-of-a-synbiotic-on-liver-fat-disease-biomarkers-and-intestinal-microbiota-in-non-alcoholic-fatty-liver-disease
#4
Eleonora Scorletti, Paul R Afolabi, Elizabeth A Miles, Debbie E Smith, Amal Almehmadi, Albandri Alshathry, Helen E Moyses, Geraldine F Clough, Mark Wright, Janisha Patel, Laure Bindels, Nathalie M Delzenne, Philip C Calder, Christopher D Byrne
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of fat-related conditions ranging from simple fatty liver, to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. There is growing evidence that NAFLD is a multisystem disease, affecting several extra-hepatic organs and regulatory pathways. Furthermore, since the gut and liver are linked anatomically via the portal vein, disturbances of the gut microbiota (dysbiosis) can affect the liver. OBJECTIVES: In patients with NAFLD, we are testing the effects of a synbiotic which is the combination of a prebiotic (fructooligosaccharides; 4 g/day) and a probiotic (Bifidobacterium animalis subsp...
May 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29787793/chlorogenic-acid-ameliorates-alcohol-induced-liver-injuries-through-scavenging-reactive-oxygen-species
#5
Hyunjin Kim, Jeong Hoon Pan, Sung Hwan Kim, Jin Hyup Lee, Jeen-Woo Park
The key role of oxidative stress in alcoholic liver disease (ALD) has been established by the large body of evidence from previous studies. Excessive consumption of ethanol induces the production of a variety of reactive oxygen species (ROS) in the liver, such as superoxide, H2 O2 , and hydroxyl radical. These products activate oxidant-sensitive signaling cascades and modulators of apoptosis. Because ROS accumulation is closely related to ALD, a number of studies have investigated the benefits of antioxidants...
May 19, 2018: Biochimie
https://www.readbyqxmd.com/read/29787603/association-of-ocular-cardiovascular-morphometric-and-lifestyle-parameters-with-retinal-nerve-fibre-layer-thickness
#6
Julia Lamparter, Irene Schmidtmann, Alexander K Schuster, Angeliki Siouli, Joanna Wasielica-Poslednik, Alireza Mirshahi, René Höhn, Josef Unterrainer, Philipp S Wild, Harald Binder, Karl Lackner, Manfred E Beutel, Thomas Münzel, Norbert Pfeiffer, Esther M Hoffmann
BACKGROUND: Glaucoma is a neurodegenerative disease, leading to thinning of the retinal nerve fibre layer (RNFL). The exact influence of ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFL thickness (RNFLT) is unknown and was analysed in a subgroup of the Gutenberg Health Study (GHS). METHODS: Global peripapillary RNFLT was measured in 3224 eyes of 1973 subjects (49% female) using spectral-domain optical coherence tomography (SD-OCT). The association of age, sex, ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFLT was analysed using Pearson correlation coefficient and fitting a linear mixed model...
2018: PloS One
https://www.readbyqxmd.com/read/29785393/monitoring-methotrexate-induced-liver-fibrosis-in-patients-with-psoriasis-utility-of-transient-elastography
#7
REVIEW
Harriet S Cheng, Marius Rademaker
Increasingly, existing evidence indicates that methotrexate-associated liver injury is related to comorbid risk factors such as diabetes, alcoholism, and obesity, rather than to methotrexate itself. Despite this fact, significant effort continues to be expended in the monitoring of low-dose methotrexate in patients with psoriasis. The gold standard investigation has been liver biopsy, but this is associated with significant morbidity and mortality. As methotrexate-induced liver injury is uncommon, the risk/benefit ratio of liver biopsy has been questioned...
2018: Psoriasis: Targets and Therapy
https://www.readbyqxmd.com/read/29783974/pathways-to-prevention-protocol-for-the-cap-climate-and-preventure-study-to-evaluate-the-long-term-effectiveness-of-school-based-universal-selective-and-combined-alcohol-misuse-prevention-into-early-adulthood
#8
Nicola C Newton, Lexine Stapinski, Tim Slade, Katrina E Champion, Emma L Barrett, Catherine Chapman, Anna Smout, Siobhan Lawler, Marius Mather, Natalie Castellanos-Ryan, Patricia J Conrod, Maree Teesson
BACKGROUND: Alcohol use and associated harms are among the leading causes of burden of disease among young people, highlighting the need for effective prevention. The Climate and Preventure (CAP) study was the first trial of a combined universal and selective school-based approach to preventing alcohol misuse among adolescents. Initial results indicate that universal, selective and combined prevention were all effective in delaying the uptake of alcohol use and binge drinking for up to 3 years following the interventions...
May 21, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29783682/heat-shock-gene-inactivation-and-protein-aggregation-with-links-to-chronic-diseases
#9
Ian James Martins
The heat shock response involved in protein misfolding is linked to the formation of toxic immunogenic proteins with heat shock proteins (HSP) as regulators of amyloid beta aggregation. The defective amyloid beta trafficking between different intracellular compartments is now relevant to HSPs and autoimmunity. Overnutrition, temperature dysregulation, and stress repress the heat shock gene Sirtuin 1 with the induction of HSP regulated amyloid beta aggregation involved in the autoimmune response. Defective circadian rhythm alterations are connected to inactivation of the peripheral sink amyloid beta clearance pathway and related to insulin resistance, protein aggregation, and autoimmune disease in non-alcoholic fatty liver disease (NAFLD) and various neurodegenerative diseases such as Alzheimer's disease...
May 18, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29783244/some-features-of-the-behavior-of-alcohol-dependent-persons
#10
Ihor М Karpinets, Oksana V Marusyn
OBJECTIVE: Introduction: Alcoholism is characterized by psychological dependence and changes in human behavior, which affects the person's relationship with the social environment. The aim: to determine the behavior of alcohol dependent persons basing on the retrospective study. PATIENTS AND METHODS: Materials and methods: On the basis of narcological offices of healthcare establishments and narcological clinic in Ivano-Frankivsk oblast, 552 people being in follow-up by a narcologist as addicted or abused have been examined for a specially developed extended program based on a standardized AUDIT screening test...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29779991/mechanical-metatarsalgia-as-a-risk-factor-for-relapse-of-morton-s-neuroma-after-ultrasound-guided-alcohol-injection
#11
Paolo Lorenzon, Carlo Rettore
Although many treatment modalities are available for Morton's neuroma, the injection of the neuroma with alcohol has gained popularity. However, recently, some investigators have observed a progressive deterioration in pain scores for patients initially pain free after the treatment. The purpose of the present retrospective comparative study was to determine whether mechanical metatarsalgia is related to symptom recurrence. We included 104 consecutive cases of ultrasound-guided alcohol injection for Morton's neuroma in 92 patients...
May 17, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29779210/the-association-between-missing-teeth-and-non-alcoholic-fatty-liver-disease-in-adults
#12
Feng Qiao, Kaiyu Fu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yang Xia, Xue Bao, Yeqing Gu, Hongbin Shi, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
AIMS: Long-term oral chronic inflammatory process is closely related to systemic inflammation, which is a main mechanism involved in non-alcoholic fatty liver disease (NAFLD). Tooth loss could reflect the accumulation of oral local inflammation, implying that number of missing teeth may associate with NAFLD. This study evaluated the association between missing teeth and presence of NAFLD in a general population. MATERIALS AND METHODS: A cross-sectional study of 24,470 adults was carried out from the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29779170/histological-improvement-of-non-alcoholic-steatohepatitis-with-a-prebiotic-a-pilot-clinical-trial
#13
Marc R Bomhof, Jill A Parnell, Hena R Ramay, Pam Crotty, Kevin P Rioux, Chris S Probert, Saumya Jayakumar, Maitreyi Raman, Raylene A Reimer
PURPOSE: In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis (NASH), a disease marked by hepatic inflammation and fibrosis. Although the precise pathophysiology of NASH is unknown, it is believed that the gut microbiota-liver axis influences the development of this disease. With few treatment strategies available for NASH, exploration of gut microbiota-targeted interventions is warranted...
May 19, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29778776/identification-and-medical-utilization-of-incident-cases-of-alcohol-dependence-a-population-based-case-control-study
#14
Chun-Hung Pan, Min-Shan Li, Tien-Wey Yang, Ming-Chyi Huang, Sheng-Shiang Su, Yen-Ni Hung, Chiao-Chicy Chen, Chian-Jue Kuo
BACKGROUND: Patients with alcohol dependence (AD) often seek help from medical professionals due to alcohol-related diseases, but the overall distribution of medical specialties identifying new AD cases is unclear. We investigated how such cases were identified and how medical resources were utilized before the identification of AD in a nationwide cohort. METHODS: We enrolled a population-based cohort (N = 1,000,000) using the National Health Insurance Research Database of Taiwan; 8181 cases with incident AD were retrieved between January 1, 2000, and December 31, 2010...
May 5, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29778667/cardiovascular-risk-factors-is-the-metabolic-syndrome-related-to-aging-epidemiology-in-a-portuguese-population
#15
Armindo Sousa Ribeiro, Rui Seixas, Juan Manuel Gálvez, Vicente Climent
AIMS: The primary objective of our study is to determine the prevalence of the metabolic syndrome in the population. The secondary objective is to determine the prevalence of cardiovascular risk factors, anthropometric alterations and the prevalence of target organ damage and their relationship with aging. MATERIAL AND METHODS: The sample for the study was obtained by means of a consecutive population-based demonstration in 803 adults over 18 years of age belonging to the labor force of the company Grupo Delta SA...
May 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29778532/non-alcoholic-fatty-liver-disease-insights-from-sphingolipidomics
#16
David J Montefusco, Jeremy C Allegood, Sarah Spiegel, L Ashley Cowart
Non-alcoholic fatty liver disease (NAFLD) is a major clinical concern and its treatment consumes abundant resources. While accumulation of lipids in hepatocytes initiates the disease, this in itself is not necessarily harmful; rather, initiation of inflammation and subsequent fibrosis and cirrhosis are critical steps in NAFLD pathology. Mechanisms linking lipid overload to downstream disease progression are not fully understood; however, bioactive lipid metabolism may underlie instigation of proinflammatory signaling...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29776914/combining-variables-for-cancer-risk-estimation-is-the-sum-better-than-the-parts
#17
EDITORIAL
Christine M Friedenreich, Anne McTiernan
Examining joint exposures of modifiable breast cancer risk factors may provide advantages over individual exposure-disease association analyses. Using the Healthy Lifestyle Index, Arthur and colleagues analyzed the joint impacts of diet, alcohol, smoking, physical activity, and obesity on breast cancer risk, and subtypes, in postmenopausal women enrolled in the Women's Health Initiative. The analysis provides data for population-attributable risk estimations and future prevention trials to target multiple risk factors...
May 18, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29775890/triterpenic-acids-enriched-fraction-from-cyclocarya-paliurus-attenuates-non-alcoholic-fatty-liver-disease-via-improving-oxidative-stress-and-mitochondrial-dysfunction
#18
Meng-Ge Zhao, Xue-Ping Sheng, Ya-Ping Huang, Yi-Ting Wang, Cui-Hua Jiang, Jian Zhang, Zhi-Qi Yin
The effects of triterpenic acids-enriched fraction from Cyclocarya paliurus (CPT) on nonalcoholic fatty liver disease (NAFLD) were investigated using in vivo and in vitro models. In high fat diet-induced Wister rats, CPT significantly increased superoxide dismutase (SOD) activity and glutathione/oxidized glutathione (GSH/GSSG) ratio, reduced malondialdehyde (MDA) and protein carbonyl (PCO) levels. Moreover, CPT restored mitochondrial membrane potential dysfunction, decreased cytochrome P450 enzyme 2E1 (CYP2E1) activity, improved nuclear factor erythroid 2-related factor 2 (Nrf2) and Nrf2-mediated antioxidant enzyme heme oxygenase1 (HO-1) expression...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29773419/a-changing-etiologic-scenario-in-liver-transplantation-for-hepatocellular-carcinoma-in-a-multicenter-cohort-study-from-latin-america
#19
Federico Piñero, Paulo Costa, Yuri Longatto Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Luis G Podestá, Lucas McCormack, Adrian Gadano, Ilka S F Fatima Boin, Parente García, Marcelo Silva
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of hepatocellular carcinoma (HCC) and liver transplantation (LT). Our study focused on changing trends of liver related HCC etiologies during the last years in Latin America. METHODS: From a cohort of 2761 consecutive adult LT patients between 2005 and 2012 in 17 different centers, 435 with HCC were included. Different periods including years 2005-2006, 2007-2008, 2009-2010 and 2011-2012 were considered...
May 14, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29770757/soya-protein-%C3%AE-conglycinin-ameliorates-fatty-liver-and-obesity-in-diet-induced-obese-mice-through-the-down-regulation-of-ppar%C3%AE
#20
Dongyang Li, Reina Ikaga, Tomomi Yamazaki
Diets high in fat can result in obesity and non-alcoholic fatty liver disease (NAFLD). The improvement of obesity and NAFLD is an important issue. β-Conglycinin, one of the soya proteins, is known to prevent hyperlipidaemia, obesity and NAFLD. Therefore, we aimed to investigate the effects of β-conglycinin on the improvement of obesity and NAFLD in high-fat (HF) diet-induced obese (DIO) mice and clarify the mechanism underlying these effects in liver and white adipose tissue (WAT). DIO male ddY mice were divided into six groups: HF, medium-fat (MF) and low-fat (LF) groups fed casein, and HF, MF and LF groups in all of which the casein was replaced by β-conglycinin...
June 2018: British Journal of Nutrition
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