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https://www.readbyqxmd.com/read/28730848/cpa-treatment-guidelines-for-individuals-at-clinical-high-risk-of-psychosis
#1
Jean Addington, Donald Addington, Sabina Abidi, Thomas Raedler, Gary Remington
OBJECTIVE: Young people who are at clinical high risk (CHR) of developing psychosis are often help seeking and have significant distress and dysfunction. There are limited guidelines for the assessment and treatment for this population. The aim of this guideline was to develop treatment recommendations for this at-risk group. METHOD: A systematic search was conducted for published guidelines for CHR. All current guidelines for schizophrenia were reviewed for treatment guidelines on individuals at CHR...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#2
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28725951/new-aspects-of-the-vulnerability-stress-model-in-general-its-relevance-in-schizophrenic-psychoses-and-the-place-of-antipsychotics
#3
EDITORIAL
Hans-Jürgen Möller
No abstract text is available yet for this article.
July 19, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28721034/readmission-after-copd-exacerbation-scale-determining-30-day-readmission-risk-for-copd-patients
#4
Christine Sm Lau, Brianna L Siracuse, Ronald S Chamberlain
BACKGROUND: COPD affects over 13 million Americans, and accounts for over half a million hospitalizations annually. The Hospital Readmission Reduction Program, established by the Affordable Care Act requires the Centers for Medicare and Medicaid Services to reduce payments to hospitals with excess readmissions for COPD as of 2015. This study sought to develop a predictive readmission scale to identify COPD patients at higher readmission risk. METHODS: Demographic and clinical data on 339,389 patients from New York and California (derivation cohort) and 258,113 patients from Washington and Florida (validation cohort) were abstracted from the State Inpatient Database (2006-2011), and the Readmission After COPD Exacerbation (RACE) Scale was developed to predict 30-day readmission risk...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28709772/physical-health-promotion-in-patients-with-functional-psychoses-receiving-community-psychiatric-services-results-of-the-physico-dsm-vr-study
#5
Elena Bonfioli, Maria Angela Mazzi, Loretta Berti, Lorenzo Burti
OBJECTIVES: Psychotic patients have poorer health behaviours, including poor diets and sedentary lifestyles increasing their risk for obesity, diabetes, hypertension, and dyslipidaemia, and tend to have a shorter life expectancy as compared to nonpsychiatric populations. Lifestyle intervention programmes that target modifiable risk factors in such patients have produced uneven results. The objective was to evaluate the efficacy of a package of health promotion strategies to improve diet and physical exercise in psychotic patients...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28704576/psychosis-an-autoimmune-disease
#6
REVIEW
Adam Aj Al-Diwani, Thomas A Pollak, Sarosh R Irani, Belinda R Lennox
Psychotic disorders are common and disabling. Overlaps in clinical course in addition to epidemiological and genetic associations raise the possibility that autoimmune mechanisms may underlie some psychoses, potentially offering novel therapeutic approaches. Several immune loci including the major histocompatibility complex and B-cell markers CD19 and CD20 achieve genome-wide significance in schizophrenia. Emerging evidence suggests a potential role via neurodevelopment in addition to classical immune pathways...
July 13, 2017: Immunology
https://www.readbyqxmd.com/read/28687870/-genuine-motor-phenomena-in-schizophrenic-psychoses-theoretical-background-and-definition-of-context
#7
D Hirjak, G Northoff, P A Thomann, K M Kubera, R C Wolf
Besides positive and negative symptoms, motor abnormalities have been increasingly recognized as central symptoms of schizophrenia. Recent investigations of antipsychotic-naive first-episode patients with schizophrenia found significantly higher rates of genuine motor abnormalities (GMA) when compared to healthy individuals. The first part of this article introduces the historical and clinical background of GMA in schizophrenia. In the second part the relevance of scientific research and clinical implication of GMA in schizophrenia are discussed...
July 7, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28686933/personal-resources-and-depression-in-schizophrenia-the-role-of-self-esteem-resilience-and-internalized-stigma
#8
Alessandro Rossi, Silvana Galderisi, Paola Rocca, Alessandro Bertolino, Paola Rucci, Dino Gibertoni, Paolo Stratta, Paola Bucci, Armida Mucci, Eugenio Aguglia, Giovanni Amodeo, Mario Amore, Antonello Bellomo, Roberto Brugnoli, Grazia Caforio, Bernardo Carpiniello, Liliana Dell'Osso, Fabio di Fabio, Massimo di Giannantonio, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Lucio Oldani, Rita Roncone, Emilio Sacchetti, Paolo Santonastaso, Alberto Siracusano, Patrizia Zeppegno, Mario Maj
Depression in schizophrenia represents a challenge from a diagnostic, psychopathological and therapeutic perspective. The objective of this study is to test the hypothesis that resilience and self-stigma affect depression severity and to evaluate the strength of their relations in 921 patients with schizophrenia. A structural equation model was tested where depression is hypothesized as affected by resilience, internalized stigma, gender and negative symptoms, with the latter two variables used as exogenous covariates and the former two as mediators...
June 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28682228/-genetics-and-epigenetics-of-schizophrenia-and-other-psychoses
#9
Boris Chaumette, Oussama Kebir, Marie-Odile Krebs
Schizophrenia and other psychoses are categorical psychiatric diagnoses corresponding to frequent and heterogeneous disorders. Their physiopathology still remains largely unknown despite numerous recent advances. In particular, the last decade has identified different types of genetic variants, thanks to emergence of high-throughput methods. These methods allow both the identification of rare variants with a large effect such as punctual mutations or copy-number variants and the identification of frequent variants with a limited effect such as polymorphisms...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/28678451/-late-life-psychotic-disorders-clinical-aspects
#10
Nadja Gardijan, Anna Szücs
Old age is a vulnerable period of life for either the apparition or the exacerbation of psychiatric disorders. Among others, psychoses are relatively frequent in the elderly. Alas diagnoses of non-organic psychoses are still matters of debate, namely because of the important variability of symptoms and the lack of data in the elderly population. DSM-5 adds only little precision to this nosographic issue. These questions are however important in practice, since they influence prognostic aspects and treatment choices...
September 21, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28675258/narcolepsy-cataplexy-and-psychosis-a-case-study
#11
F Canellas-Dols, C Delgado, C Arango-Lopez, R Peraita-Adrados
AIMS: To report a challenging patient a girl who developed narcolepsyy with cataplexy (NT1) and a psychosis during adolescence. To discuss diagnostic and therapeutic challenges of the comorbid cases. CASE REPORT: A 14-year-old girl was referred to Sleep and Epilepsy Unit for excessive daytime sleepiness, impaired nocturnal sleep, binge eating and weight gain, over the last year. After being diagnosed with a NT1 the patient was treated with modafinil and sodium oxybate...
July 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28673958/identifying-primary-care-quality-indicators-for-people-with-serious-mental-illness-a-systematic-review
#12
Christoph Kronenberg, Tim Doran, Maria Goddard, Tony Kendrick, Simon Gilbody, Ceri R Dare, Lauren Aylott, Rowena Jacobs
BACKGROUND: Serious mental illness (SMI) - which comprises long-term conditions such as schizophrenia, bipolar disorder, and other psychoses - has enormous costs for patients and society. In many countries, people with SMI are treated solely in primary care, and have particular needs for physical care. AIM: The objective of this study was to systematically review the literature to create a list of quality indicators relevant to patients with SMI that could be captured using routine data, and which could be used to monitor or incentivise better-quality primary care...
July 3, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28670977/ventricular-volumes-across-stages-of-schizophrenia-and-other-psychoses
#13
Gregor E Berger, Cali F Bartholomeusz, Stephen J Wood, Anthony Ang, Lisa J Phillips, Tina Proffitt, Warrick J Brewer, Deidre J Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R Yung, Patrick D McGorry, Christos Pantelis
OBJECTIVE: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. METHODS: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28658515/antipsychotic-combinations-for-schizophrenia
#14
REVIEW
Javier Ortiz-Orendain, Santiago Castiello-de Obeso, Luis Enrique Colunga-Lozano, Yue Hu, Nicola Maayan, Clive E Adams
BACKGROUND: Many people with schizophrenia do not achieve a satisfactory treatment response with their initial antipsychotic drug treatment. Sometimes a second antipsychotic, in combination with the first, is used in these situations. OBJECTIVES: To examine whether:1. treatment with antipsychotic combinations is effective for schizophrenia; and2. treatment with antipsychotic combinations is safe for the same illness. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's register which is based on regular searches of CINAHL, BIOSIS, AMED, Embase, PubMed, MEDLINE, PsycINFO, and registries of clinical trials...
June 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28658249/similar-white-matter-changes-in-schizophrenia-and-bipolar-disorder-a-tract-based-spatial-statistics-study
#15
Letizia Squarcina, Marcella Bellani, Maria Gloria Rossetti, Cinzia Perlini, Giuseppe Delvecchio, Nicola Dusi, Marco Barillari, Mirella Ruggeri, Carlo A Altamura, Alessandra Bertoldo, Paolo Brambilla
Several strands of evidence reported a significant overlapping, in terms of clinical symptoms, epidemiology and treatment response, between the two major psychotic disorders-Schizophrenia (SCZ) and Bipolar Disorder (BD). Nevertheless, the shared neurobiological correlates of these two disorders are far from conclusive. This study aims toward a better understanding of possible common microstructural brain alterations in SCZ and BD. Magnetic Resonance Diffusion data of 33 patients with BD, 19 with SCZ and 35 healthy controls were acquired...
2017: PloS One
https://www.readbyqxmd.com/read/28651657/association-between-violent-crime-and-psychosis-in-men-serving-prison-terms
#16
Javier Saavedra, Marcelino López, M Eva Trigo
Psychosis has been associated with committing violent crimes. However, it has been reported that the association is mediated by toxin consumption, personality disorders, and positive symptoms. This study will examine the relationship between different psychological disorders and sociodemographic variables, and violent crime perpetration in a sample of 472 men serving prison terms in Andalusia, Spain. A correlation-based, retrospective study was conducted and data were analyzed through logistic regression. The sample is representative of the Andalusian prison population, with a 95% level of confidence and ...
June 27, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28645250/labour-market-marginalisation-after-mental-disorders-among-young-natives-and-immigrants-living-in-sweden
#17
Magnus Helgesson, Petter Tinghög, Thomas Niederkrotenthaler, Fredrik Saboonchi, Ellenor Mittendorfer-Rutz
BACKGROUND: The aim was to investigate the associations between mental disorders and three different measures of labour-market marginalisation, and differences between native Swedes and immigrants. METHODS: The study comprised 1,753,544 individuals, aged 20-35 years, and resident in Sweden 2004. They were followed 2005-2011 with regard to disability pension, sickness absence (≥90 days) and unemployment (≥180 days). Immigrants were born in Western countries (Nordic countries, EU, Europe outside EU or North-America/Oceania), or in non-Western countries (Africa, Asia or South-America)...
June 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28642258/ethnicity-and-long-term-course-and-outcome-of-psychotic-disorders-in-a-uk-sample-the-%C3%A3-sop-10-study
#18
Craig Morgan, Paul Fearon, Julia Lappin, Margaret Heslin, Kim Donoghue, Ben Lomas, Ulrich Reininghaus, Adanna Onyejiaka, Tim Croudace, Peter B Jones, Robin M Murray, Gillian A Doody, Paola Dazzan
BackgroundThe incidence of psychotic disorders is elevated in some minority ethnic populations. However, we know little about the outcome of psychoses in these populations.AimsTo investigate patterns and determinants of long-term course and outcome of psychoses by ethnic group following a first episode.MethodÆSOP-10 is a 10-year follow-up of an ethnically diverse cohort of 532 individuals with first-episode psychosis identified in the UK. Information was collected, at baseline, on clinical presentation and neurodevelopmental and social factors and, at follow-up, on course and outcome...
June 22, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28634109/cannabis-associated-psychosis-neural-substrate-and-clinical-impact
#19
REVIEW
R M Murray, A Englund, A Abi-Dargham, D Lewis, M Di Forti, C Davies, M Sherif, P McGuire, C D'Souza
Prospective epidemiological studies have consistently demonstrated that cannabis use is associated with an increased subsequent risk of both psychotic symptoms and schizophrenia-like psychoses. Early onset of use, daily use of high-potency cannabis, and synthetic cannabinoids carry the greatest risk. The risk-increasing effects are not explained by shared genetic predisposition between schizophrenia and cannabis use. Experimental studies in healthy humans show that cannabis and its active ingredient, delta-9-tetrahydrocannabinol (THC), can produce transient, dose-dependent, psychotic symptoms, as well as an array of psychosis-relevant behavioral, cognitive and psychophysiological effects; the psychotogenic effects can be ameliorated by cannabidiol (CBD)...
June 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28623386/the-antipsychotic-agent-quetiapine-is-increasingly-not-used-as-such-dispensed-prescriptions-in-norway-2004-2015
#20
Pål Gjerden, Jørgen G Bramness, Ingunn Fride Tvete, Lars Slørdal
PURPOSE: The antipsychotic agent quetiapine was introduced in Norway in 2003. We have assessed changes in dispensed prescriptions, including dosing, of quetiapine in Norway from 2004 to 2015. METHODS: Data on the sales of antipsychotics and antidepressants were drawn from the Norwegian Prescription Database. A total of 47,474 outpatients filled 195,622 prescriptions of quetiapine. Reimbursement codes, use of antipsychotics or antidepressants 12 months prior to the first prescription of quetiapine and estimated mean volume used measured as defined daily doses (DDDs) per day were used as proxies for diagnoses...
June 16, 2017: European Journal of Clinical Pharmacology
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