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Mariusz Z Ratajczak, Daniel Pedziwiatr, Monika Cymer, Magda Kucia, Jolanta Kucharska-Mazur, Jerzy Samochowiec
Evidence has accumulated that the occurrence of psychiatric disorders is related to chronic inflammation. In support of this linkage, changes in the levels of circulating pro-inflammatory cytokines and chemokines in the peripheral blood (PB) of psychiatric patients as well as correlations between chronic inflammatory processes and psychiatric disorders have been described. Furthermore, an inflammatory process known as "sterile inflammation" when initiated directly in brain tissue may trigger the onset of psychoses...
2018: Frontiers in Psychiatry
Shiv Gautam, Akhilesh Jain, Manaswi Gautam, Anita Gautam
No abstract text is available yet for this article.
February 2018: Indian Journal of Psychiatry
Carlos E León
We present an important advance in psychiatry regarding the phenomenon of recovery. Comparative studies between Open Dialogue (OD) and current treatments of schizophrenia and other non-affective psychoses point to an important difference in short and long-term results in favor of this approach developed in Western Lapland. This suggests that OD treatment enhances durable recovery. The prognosis of recovery would depend mainly on the treatment received, and would not be necessarily partial or dependent on a mysterious personal quality...
September 2017: Vertex: Revista Argentina de Psiquiatriá
W Veling, I E C Sommer, R Bruggeman, L de Haan
Personalised medicine (pm) means treatment that specifically targets the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics.<br/> AIM: To update our knowledge about the current use of pm in the treatment of psychotic disorders.<br/> METHOD: Review of the literature on pm for psychoses.<br/> RESULTS: At the moment, genetic and other biological characteristics cannot be used for the diagnosis and treatment of psychotic disorders because they are not sensitive enough and their specificity is too low...
2018: Tijdschrift Voor Psychiatrie
Susanna Zarafonitis-Müller, Karolina Leopold, Marcel Batra, Michèle Kallenbach, Eva Burkhardt, Dorothea Jäckel, Andreas Bechdolf
BACKGROUND: The present study evaluated service use of our newly established Early Intervention and Treatment Centre (FRITZ) in Berlin for young adults with first or early psychosis with and without migration background. METHODS: We conducted a retrospective chart review of in-patients with early psychosis who were admitted to FRITZ between May 2014 and May 2015. We investigated the proportion of patients with migration background, sociodemographic and clinical characteristics of patients...
March 7, 2018: Psychiatrische Praxis
Shiraz Ahmed, Kate Zara Peters, Nandini Chakraborty
AIM: The present study aimed to determine the influence of demographic and clinical features on the likelihood of patients being discharge to primary vs secondary care. The overarching aim of this service evaluation is to assess factors affecting discharge and determine important modulators of discharge destination to inform care planning in services. METHOD: Clinical and demographic data were extracted from patient notes of those discharged from the Psychosis Intervention and Early Recovery (PIER) service in Leicestershire between January 2005 and December 2013...
March 7, 2018: Early Intervention in Psychiatry
Elise Harder, Kirsten E Juul, Signe M Jensen, Louise T Thomsen, Kirsten Frederiksen, Susanne K Kjaer
Cervical cancer occurs most often in under-screened women. In this nationwide register study, we described differences in sociodemographic characteristics between passive and active non-participants and examined socio-demographic characteristics, reproductive history, and mental and physical health as potential determinants for passive non-participation compared with participation in the Danish cervical cancer screening program. Screening history in women aged 23-49 years invited for cervical cancer screening in 2008-2009 was retrieved from the Danish Pathology Databank with information about dates of invitation and unsubscription...
March 6, 2018: Preventive Medicine
Brigitte Ramsauer, Sandra Achtergarde
BACKGROUND: Maternal postpartum psychoses pose a serious risk to the mother-infant interaction. It is unclear how different subtypes of postpartum psychosis, including acute and chronic, might differentially affect the mother-infant interaction. METHOD: A systematic search of electronic journal databases was performed. RESULTS: This systematic review yielded 17 studies with adequate overall study quality. They focused on child custody and involvement of social services as indirect indicators of the mother-infant interaction, observed mother-infant interactions as direct indicators, or potential transitional mechanisms, including memory processing, mind-mindedness, and affect recognition, that may partially explain the effects of psychotic disorders...
February 26, 2018: Schizophrenia Research
Kelly K Anderson, Ross Norman, Arlene MacDougall, Jordan Edwards, Lena Palaniyappan, Cindy Lau, Paul Kurdyak
OBJECTIVE: Early psychosis intervention (EPI) programs improve clinical and functional outcomes for people with first-episode psychosis. Less is known about the impact of these programs on the larger health care system. The authors sought to compare indicators of health service use, self-harm, suicide, and mortality between people with first-episode psychosis who were using EPI services and a propensity-matched group of concurrent control subjects who were not accessing EPI services. METHOD: A retrospective cohort of incident cases of nonaffective psychosis in the catchment area of the Prevention and Early Intervention Program for Psychoses in London, Ontario, between 1997 and 2013 was constructed using health administrative data...
March 2, 2018: American Journal of Psychiatry
Paul Eling, Alla Vein
This study focuses on two outstanding psychiatrists: the Frenchman Valentin Magnan (1835-1916) and the Russian Sergey Korsakov (1854-1900). Their international renown is primarily associated with their investigations into health consequences of alcohol consumption; they were pioneers in this field, and happened to know each other well. The similarities and differences are shown in social and scientific approaches adopted by these two scientists. In his work, Magnan focused mainly on absinthe and epilepsy; he considered alcoholism to be a hereditary mental disorder...
February 22, 2018: Journal of the History of the Neurosciences
M C Castillejos, C Martín-Pérez, B Moreno-Küstner
BACKGROUND: Considering existing knowledge on the relationship between certain environmental factors and incidence rates of psychosis, we carried out a systematic review to provide a broad and updated picture of the incidences of different psychotic disorder subgroups worldwide and how some environmental factors influence these rates. METHODS: Studies with original data related to the incidence of psychosis (published between 2000 and 2015) were identified via searching electronic databases (CINAHL, MEDLINE, PSYCINFO, PUBMED, and SCOPUS)...
February 22, 2018: Psychological Medicine
D A Smirnova, N N Petrova, A V Pavlichenko, I A Martynikhin, M V Dorofeikova, V I Eremkin, O V Izmailova, Yu Yu Osadshiy, D V Romanov, D A Ubeikon, I A Fedotov, M S Sheifer, A D Shustov, A A Yashikhina, M Clark, J Badcock, A Watterreus, V Morgan, A Jablensky
OBJECTIVES: The Diagnostic Interview for Psychoses (DIP) was developed to enhance the quality of diagnostic assessment of psychotic disorders. The aim of the study was the adaptation of the Russian language version and evaluation of its validity and reliability. MATERIAL AND METHODS: Ninety-eight patients with psychotic disorders (89 video recordings) were assessed by 12 interviewers using the Russian version of DIP at 7 clinical sites (in 6 cities of the Russian Federation)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Silvana Galderisi, Paola Rucci, Brian Kirkpatrick, Armida Mucci, Dino Gibertoni, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Gregory P Strauss, Eugenio Aguglia, Antonello Bellomo, Martino Belvederi Murri, Paola Bucci, Bernardo Carpiniello, Anna Comparelli, Alessandro Cuomo, Domenico De Berardis, Liliana Dell'Osso, Fabio Di Fabio, Barbara Gelao, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Giulia Orsenigo, Francesca Pacitti, Rita Roncone, Paolo Santonastaso, Alberto Siracusano, Annarita Vignapiano, Antonio Vita, Patrizia Zeppegno, Mario Maj
Importance: Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. Objective: To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach...
February 14, 2018: JAMA Psychiatry
A Richard Green, Peter M Haddad, Jeffrey K Aronson
AIMS: To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS: We systematically reviewed advertisements promoting drugs for specific therapeutic areas, namely central nervous system disorders (anxiety and sleep disorders, depression, psychoses, and Parkinson's disease), respiratory disorders, cardiovascular disorders, and gastrointestinal disorders...
February 14, 2018: British Journal of Clinical Pharmacology
Dan G Blazer
Hearing loss is among the most frequent problems experienced by older adults, yet psychiatrists and other clinicians often ignore the problem as an aggravation rather than recognizing that the problem might benefit from appropriate hearing health care. Many psychiatric disorders have been associated with hearing loss, including depression, schizophrenia and other psychoses, anxiety, and neurocognitive disorders. In this article, hearing loss among older adults is reviewed, with special attention directed toward the recognition and proper referral to a hearing health care provider...
March 2018: Psychiatric Clinics of North America
Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
Currently used antipsychotics are characterized by multireceptor mode of action. While antagonism of dopamine D2 receptors is responsible for the alleviation of "positive" symptoms of schizophrenia and the effects at other, particularly serotonergic receptors are necessary for their additional therapeutic effects, there is no consensus regarding an "ideal" target engagement. Here, a detailed SAR analysis in a series of 45 novel azinesulfonamides of cyclic amine derivatives, involving the aryl-piperazine/piperidine pharmacophore, central alicyclic amine and azinesulfonamide groups has led to the selection of (S)-4-((2-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)isoquinoline (62)...
February 10, 2018: European Journal of Medicinal Chemistry
Matteo Caloro, Giuseppa Calabrò, Eleonora de Pisa, Enrico Rosini, Georgios D Kotzalidis, Davide Lonati, Carlo Alessandro Locatelli, Pietro Papa, Fabrizio Schifano, Paolo Girardi
: Novel psychoactive substance use is a major social concern. Their use may elicit or uncover unpredictably as yet undescribed clinical pictures. We aimed to illustrate a multisubstance use case indistinguishable from paranoid schizophrenia, so to alert clinicians on possibly misdiagnosing substance-induced psychotic disorders. CASE REPORT: We describe a case of a 32-year-old man who started at 18 years with cannabinoids and ketamine, and is currently using N-methyl-D-aspartate (NMDA) antagonists...
February 2, 2018: Journal of Addiction Medicine
Jennifer L Payne
No abstract text is available yet for this article.
February 1, 2018: American Journal of Psychiatry
Diana M Bongiorno, Gail L Daumit, Rebecca F Gottesman, Roland Faigle
BACKGROUND AND PURPOSE: Intravenous thrombolysis (IVT) improves outcomes after acute ischemic stroke but is underused in certain patient populations. Mental illness is pervasive in the United States, and patients with comorbid psychiatric disease experience inequities in treatment for a range of conditions. We aimed to determine whether comorbid psychiatric disease is associated with differences in IVT use in acute ischemic stroke. METHODS: Acute ischemic stroke admissions between 2007 and 2011 were identified in the Nationwide Inpatient Sample...
January 26, 2018: Stroke; a Journal of Cerebral Circulation
Laura N Castellani, Willem T Peppler, Paula M Miotto, Natasha Bush, David C Wright
Olanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6...
January 15, 2018: Scientific Reports
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