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https://www.readbyqxmd.com/read/28911050/motor-abnormalities-from-neurodevelopmental-to-neurodegenerative-through-functional-neuro-psychiatric-disorders
#1
Victor Peralta, Manuel J Cuesta
Background: Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to a great extent on schizophrenia, and as a consequence their prevalence and featural properties in other psychiatric or neuropsychiatric disorders are poorly known. In this article, we evaluated the extent to which catatonic, extrapyramidal and neurological soft signs, and their associated clinical features, are present transdiagnostically...
September 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28903079/escalating-patterns-of-emergency-health-care-prior-to-first-admission-with-amphetamine-psychosis-a-window-of-opportunity
#2
Grant Sara, Julia Lappin, Timothy Dobbins, Adrian J Dunlop, Louisa Degenhardt
AIM: To describe health service contact in the two years prior to a first hospital admission with amphetamine-related psychosis, and to identify possible opportunities for early intervention. METHOD: Routine health data collections were used to identify 6130 persons aged 16-65 who had a first hospital admission with amphetamine-related psychosis in New South Wales (NSW), Australia, between 2005 and 2016. Health service contacts in the two years prior to first admission were identified, using public hospital, emergency department and community mental health data...
September 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28901206/rural-urban-differences-in-accessing-mental-health-treatment-in-patients-with-psychosis
#3
Jagadisha Thirthalli, K Shanivaram Reddy, Manoranjitha Kare, Soumitra Das, B N Gangadhar
BACKGROUND: Delay in accessing psychiatric treatment has considerable influence on the outcome of psychoses. Systematic studies examining the source of the delay are lacking in India. In this article, we examine rural-urban differences regarding delay in accessing psychiatric care in patients with psychosis, an issue which was hitherto not studied. AIMS: To evaluate the rural-urban differences in treatment seeking among patients with psychosis. METHODS: Patients with psychotic disorders who presented to the outpatient department of an academic psychiatric institute for the first time ( n = 551) were interviewed using a semi-structured interview tool to assess the date of onset of illness...
September 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28898305/-cannabis-and-its-association-with-psychosis-what-do-we-know
#4
Lucía Seré, Dolores Cardona, Marcelo Cetkovich
Psychoses are a group of diseases that cause enormous health and emotional burden for the patient and their families. In recent decades, the need for early intervention to improve their prognosis has been highlighted. It has long been postulated that cannabis use is a risk factor added to other factors such as genetics and developmental abnormalities. For this reason, and in the light of a growing movement for legalization of its use, it is vitally important to have reliable information to understand the details of the relationship between cannabis abuse and the development of psychosis...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28889048/mania-triggered-by-sleep-loss-and-risk-of-postpartum-psychosis-in-women-with-bipolar-disorder
#5
Katie J S Lewis, Arianna Di Florio, Liz Forty, Katherine Gordon-Smith, Amy Perry, Nick Craddock, Lisa Jones, Ian Jones
BACKGROUND: Women with bipolar disorder are at high risk of affective psychoses following childbirth (i.e. "postpartum psychosis", PP) and there is a need to identify which factors underlie this increased risk. Vulnerability to mood dysregulation following sleep loss may influence risk of PP, as childbirth is typified by sleep disruption. We investigated whether a history of mood episodes triggered by sleep loss was associated with PP in women with bipolar disorder (BD). METHODS: Participants were 870 parous women with BD recruited to the Bipolar Disorder Research Network...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28888361/increased-platelet-glycogen-sysnthase-kinase-3beta-in-first-episode-psychosis
#6
Helena P G Joaquim, Marcus V Zanetti, Mauricio H Serpa, Martinus T Van de Bilt, Paulo C Sallet, Tiffany M Chaim, Geraldo F Busatto, Wagner F Gattaz, Leda L Talib
Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naïve first-episode psychosis patients (n=43) at baseline and following symptom remission, and in healthy controls (n=77). At baseline GSK3B total level was higher in patients (p<0.001). In schizophrenia spectrum patients (n=25) GSK3B total and phosphorylated levels were higher than in controls and patients with other non-affective psychotic disorders (n=18) (p<0...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28888149/the-impact-of-alcohol-policies-on-alcohol-attributable-diseases-in-taiwan-a-population-based-study
#7
Yung-Hsiang Ying, Yung-Ching Weng, Koyin Chang
BACKGROUND: Taiwan has some of the strictest alcohol-related driving laws in the world. However, its laws continue to be toughened to reduce the ever-increasing social cost of alcohol-related harm. AIM: This study assumes that alcohol-related driving laws show a spillover effect such that behavioral changes originally meant to apply behind the wheel come to affect drinking behavior in other contexts. The effects of alcohol driving laws and taxes on alcohol-related morbidity are assessed; incidence rates of alcohol-attributable diseases (AAD) serve as our measure of morbidity...
September 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28881360/-is-the-theoretical-support-for-the-improvement-of-brain-plasiticity-in-schizophrenic-psychoses-adequate
#8
Peter Falkai
No abstract text is available yet for this article.
September 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28865428/psychosocial-stressors-contributing-to-emergency-psychiatric-service-utilization-in-a-sample-of-ethno-culturally-diverse-clients-with-psychosis-in-toronto
#9
Martin Rotenberg, Andrew Tuck, Kwame McKenzie
BACKGROUND: Understanding the psychosocial stressors of people with psychoses from minority ethnic groups may help in the development of culturally appropriate services. This study aimed to compare psychosocial factors associated with attendance at an emergency department (ED) for six ethnic groups. Preventing crises or supporting people better in the community may decrease hospitalization and improve outcomes. METHOD: A cohort was created by retrospective case note analysis of people of East-Asian, South-Asian, Black-African, Black-Caribbean, White-North American and White-European origin groups attending a specialized psychiatric ED in Toronto with a diagnosis of psychosis between 2009 and 2011...
September 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28864283/covariation-between-motor-signs-and-negative-symptoms-in-drug-naive-subjects-with-schizophrenia-spectrum-disorders-before-and-after-antipsychotic-treatment
#10
Victor Peralta, Elena García de Jalón, María S Campos, Manuel J Cuesta
Objective To examine the covariation between negative symptoms and motor signs in a broad sample of drug-naïve subjects with schizophrenia-spectrum psychoses before and after inception of antipsychotic medication. METHODS: One-hundred and eighty-nine antipsychotic-naïve subjects with DSM-IV schizophrenia-spectrum psychoses were assessed for negative symptoms including affective flattening, alogia, avolition/apathy and anhedonia/associality, and motor signs including catatonia, parkinsonism and dyskinesia...
August 29, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28856687/a-novel-relationship-for-schizophrenia-bipolar-and-major-depressive-disorder-part-3-evidence-from-chromosome-3-high-density-association-screen
#11
Xing Chen, Feng Long, Bin Cai, Xiaohong Chen, Gang Chen
Familial clustering of schizophrenia(SCZ), bipolar disorder (BPD), and major depressive disorder (MDD) was systematically reported (Aukes et al, Genet Med 2012, 14, 338-341) and convergent evidence from genetics, symptomatology and psychopharmacology imply that there are intrinsic connections between these three major psychiatric disorders, for example, any two or even three of these disorders could co-exist in some families. A total of 60, 838 single-nucleotide polymorphisms (SNPs)on chromosome 3 were genotyped by Affymetrix Genome-Wide Human SNP array 6...
August 30, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28852995/-key-topics-in-austrian-child-and-adolescent-psychiatry-2007-2017
#12
Andreas Karwautz, Cvetka F Lipuš, Martin Fuchs
The medical speciality "Child and Adolescent Psychiatry" exists since 2007. 2015 a new training regulation defined an increment to "Child and Adolescent Psychiatry and Psychotherapeutic Medicine". To document the achievements in research within the last 10 years for the first time, all papers listed in Pubmed and all books published by the member of the ÖGKJP were summarized. Additionally, the clinical/scientific key aspects of all large teaching centres were documented.All members of the ÖGKJP are scientifically active in various areas of child psychiatry...
August 30, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28818505/schizophrenia-with-prominent-catatonic-features-a-selective-review
#13
Gabor S Ungvari, Jozsef Gerevich, Rozália Takács, Gábor Gazdag
A widely accepted consensus holds that a variety of motor symptoms subsumed under the term 'catatonia' have been an integral part of the symptomatology of schizophrenia since 1896, when Kraepelin proposed the concept of dementia praecox (schizophrenia). Until recently, psychiatric classifications included catatonic schizophrenia mainly through tradition, without compelling evidence of its validity as a schizophrenia subtype. This selective review briefly summarizes the history, psychopathology, demographic and epidemiological data, and treatment options for schizophrenia with prominent catatonic features...
August 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28812313/current-and-potential-pharmacological-and-psychosocial-interventions-for-anxiety-symptoms-and-disorders-in-patients-with-schizophrenia-structured-review
#14
REVIEW
Fleur M Howells, David G Kingdon, David S Baldwin
OBJECTIVE: Between 30% and 62% of patients with schizophrenia present with co-morbid anxiety disorders that are associated with increased overall burden. Our aim was to summarize current and potential interventions for anxiety in schizophrenia. DESIGN: Structured review, summarizing pharmacological and psychosocial interventions used to reduce anxiety in schizophrenia and psychosis. RESULTS: Antipsychotics have been shown to reduce anxiety, increase anxiety, or have no effect...
August 15, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28805304/a-systematic-review-and-meta-analysis-of-mental-health-service-use-in-people-who-report-psychotic-experiences
#15
REVIEW
Vishal Bhavsar, Philip McGuire, James MacCabe, Dominic Oliver, Paolo Fusar-Poli
BACKGROUND: Self-reported psychotic experiences (PEs) are associated with psychopathology of all kinds, not just psychoses. However, systematic reviews on the relevance of this for health services are unavailable. Furthermore, whether association with service use is confounded by other psychopathology is unknown, and is relevant to prevention and treatment. OBJECTIVES: Literature examining associations between PEs and service use was systematically reviewed. Study quality and the direction and extent of any associations were assessed, and meta-analysis conducted...
August 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28781208/the-blood-brain-barrier-in-psychosis
#16
REVIEW
Thomas A Pollak, Svetlana Drndarski, James M Stone, Anthony S David, Philip McGuire, N Joan Abbott
Blood-brain barrier pathology is recognised as a central factor in the development of many neurological disorders, but much less is known about the role of the blood-brain barrier in psychiatric disorders. We review post-mortem, serum-biomarker, CSF-biomarker, and neuroimaging studies that have examined blood-brain barrier structure and function in schizophrenia and related psychoses. We consider how blood-brain barrier dysfunction could relate to glutamatergic and inflammatory abnormalities, which are increasingly understood to play a part in the pathogenesis of psychosis...
August 3, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28766129/use-and-safety-of-antiepileptic-drugs-in-psychiatric-inpatients-data-from-the-amsp-study
#17
Katrin Druschky, Stefan Bleich, Renate Grohmann, Rolf R Engel, Alexandra Kleimann, Susanne Stübner, Waldemar Greil, Sermin Toto
The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%...
August 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28756110/a-comparative-meta-analysis-of-neurocognition-in-first-degree-relatives-of-patients-with-schizophrenia-and-bipolar-disorder
#18
E Bora
OBJECTIVE: Cognitive impairment is a familial and heritable aspect of major psychoses and might be a shared vulnerability marker for schizophrenia and BP. However, it is not clear whether some aspects of cognitive deficits are uniquely associated with risk for specific diagnoses. METHODS: A novel meta-analysis of cognitive functions in first-degree relatives of probands with bipolar disorder (BP-Rel) and schizophrenia (Sch-Rel) was conducted. Current meta-analysis included 20 studies and compared cognitive functions of 1341 Sch-Rel, 939 BP-Rel and 1427 healthy controls...
July 5, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28730848/canadian-treatment-guidelines-for-individuals-at-clinical-high-risk-of-psychosis
#19
Jean Addington, Donald Addington, Sabina Abidi, Thomas Raedler, Gary Remington
OBJECTIVE: Young people who are at clinical high risk (CHR) of developing psychosis are often help seeking and have significant distress and dysfunction. There are limited guidelines for the assessment and treatment for this population. The aim of this guideline was to develop treatment recommendations for this at-risk group. METHOD: A systematic search was conducted for published guidelines for CHR. All current guidelines for schizophrenia were reviewed for treatment guidelines on individuals at CHR...
September 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#20
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
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