Yanling Liu, Jonathon Klein, Richa Bajpai, Li Dong, Quang Tran, Pandurang Kolekar, Jenny L Smith, Rhonda E Ries, Benjamin J Huang, Yi-Cheng Wang, Todd A Alonzo, Liqing Tian, Heather L Mulder, Timothy I Shaw, Jing Ma, Michael P Walsh, Guangchun Song, Tamara Westover, Robert J Autry, Alexander M Gout, David A Wheeler, Shibiao Wan, Gang Wu, Jun J Yang, William E Evans, Mignon Loh, John Easton, Jinghui Zhang, Jeffery M Klco, Soheil Meshinchi, Patrick A Brown, Shondra M Pruett-Miller, Xiaotu Ma
Oncogenic fusions formed through chromosomal rearrangements are hallmarks of childhood cancer that define cancer subtype, predict outcome, persist through treatment, and can be ideal therapeutic targets. However, mechanistic understanding of the etiology of oncogenic fusions remains elusive. Here we report a comprehensive detection of 272 oncogenic fusion gene pairs by using tumor transcriptome sequencing data from 5190 childhood cancer patients. We identify diverse factors, including translation frame, protein domain, splicing, and gene length, that shape the formation of oncogenic fusions...
April 5, 2023: Nature Communications