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https://www.readbyqxmd.com/read/28740603/an-atr-ftir-sensor-unraveling-the-drug-intervention-of-methylene-blue-congo-red-and-berberine-on-human-tau-and-a%C3%AE
#1
Jonas Schartner, Andreas Nabers, Brian Budde, Julia Lange, Nina Hoeck, Jens Wiltfang, Carsten Kötting, Klaus Gerwert
Alzheimer's disease affects millions of human beings worldwide. The disease progression is characterized by the formation of plaques and neurofibrillary tangles in the brain, which are based on aggregation processes of the Aβ peptide and tau protein. Today there is no cure and even no in vitro assay available for the identification of drug candidates, which provides direct information concerning the protein secondary structure label-free. Therefore, we developed an attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) sensor, which uses surface bound antibodies to immobilize a desired target protein...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28738932/soft-tissue-malignancy-due-to-long-standing-foreign-bodies-after-shotgun-blast
#2
Charles T Blue, Emily A Pospiech, James M Lewis, Laurentia Nodit
No abstract text is available yet for this article.
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28736850/progressive-ataxia-and-palatal-tremor-two-autopsy-cases-of-a-novel-tauopathy
#3
Andrew F Gao, Achinoam Faust-Socher, Maryam Al-Murshed, Marc R Del Bigio, Anthony E Lang, David G Munoz
BACKGROUND: Sporadic progressive ataxia and palatal tremor is a rare syndrome characterized by mid- to late-adult-onset symptomatic palatal tremor and slowly progressive cerebellar ataxia. To date, there has been only one autopsy report, which described a novel 4-repeat tauopathy with hypertrophic olivary degeneration and tau-positive inclusions in olivary neurons and dystrophic neuritic processes termed glomeruloid bodies. We report on 2 additional autopsy cases. METHODS: Sections from selected paraffin-embedded brain regions were stained with hematoxylin and eosin/Luxol fast blue and processed for phosphorylated tau, 3-repeat tau, 4-repeat tau, neurofilament, glial fibrillary acid protein, phosphorylated α-synuclein, phosphorylated TAR DNA-binding protein 43, beta-amyloid, and p62 immunohistochemistry...
July 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28734789/weathered-mc252-crude-oil-induced-anemia-and-abnormal-erythroid-morphology-in-double-crested-cormorants-phalacrocorax-auritus-with-light-microscopic-and-ultrastructural-description-of-heinz-bodies
#4
Kendal E Harr, Fred L Cunningham, Chris A Pritsos, Karen L Pritsos, Thivanka Muthumalage, Brian S Dorr, Katherine E Horak, Katie C Hanson-Dorr, Karen M Dean, Dave Cacela, Andrew K McFadden, Jane E Link, Katherine A Healy, Pete Tuttle, Steven J Bursian
Injury assessment of birds following the Deepwater Horizon (DWH) oil spill in 2010 was part of the Natural Resource Damage Assessment. One reported effect was hemolytic anemia with the presence of Heinz bodies (HB) in birds, however, the role of route and magnitude of exposure to oil is unknown. The purpose of the present study was to determine if double-crested cormorants (Phalacocorax auritis; DCCO) exposed orally and dermally to artificially weathered crude oil would develop hemolytic anemia including HB and reticulocytosis...
July 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28730841/effectiveness-of-a-worksite-intervention-for-male-construction-workers-on-dietary-and-physical-activity-behaviors-body-mass-index-and-health-outcomes-results-of-a-randomized-controlled-trial
#5
Laura Viester, Evert A L M Verhagen, Paulien M Bongers, Allard J van der Beek
PURPOSE: To evaluate the effectiveness of an individually tailored intervention for improvement in lifestyle behavior, health indicators, and prevention and reduction of overweight among construction workers. DESIGN: Randomized controlled trial. SETTING: Various blue-collar departments of a large construction company in the Netherlands. PARTICIPANTS: Blue-collar workers randomized to an intervention (n = 162) or a control group (n = 152)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28729713/tunable-uptake-release-mechanism-of-protein-microgel-particles-in-biomimicking-environment
#6
A Pepe, P Podesva, G Simone
Microgels are intra-molecular crosslinked macromolecules that can be used as vehicles to deliver and release drugs at the point-of-need in the patient's body. Here, gelatin microgels were formed from microfluidics droplets, stabilised by aldehydes and frozen into a spheroidal shape. Microgel morphology and response to external stimuli were characterised. It was found that the behaviour of the spheroidal microgels was sensitive to both pH and ionic strength and that the distribution of charges into the microgels affected the behaviour of swelling and uptake...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720755/functional-variants-of-the-melanocortin-4-receptor-associated-with-the-odontoceti-and-mysticeti-suborders-of-cetaceans
#7
Liyuan Zhao, Xiaofan Zhou, Antonis Rokas, Roger D Cone
Cetaceans, a group of mammals adapted to the aquatic environment that descended from terrestrial artiodactyls, exhibit tremendous interspecific differences in a number of phenotypes, including feeding behavior, such as filter feeding in the Mysticeti vs prey-hunting Odontoceti, and size, with the smallest cetacean, the vaquita, at 1.4 meters and the largest, the blue whale, reaching 33 meters. The Melanocortin-4 receptor (MC4R) regulates food intake, energy balance, and somatic growth in both mammals and teleosts...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713614/condition-medium-of-cerebrospinal-fluid-and-retinoic-acid-induces-the-transdifferentiation-of-human-dental-pulp-stem-cells-into-neuroglia-and-neural-like-cells
#8
Sara Haratizadeh, Maryam Nazm Bojnordi, Shahram Darabi, Narges Karimi, Mehrdad Naghikhani, Hatef Ghasemi Hamidabadi, Morteza Seifi
Cerebrospinal fluid (CSF) contains several molecules which are essential for neurogenesis. Human dental pulp stem cells (hDPSCs) are putatively neural crest cell-derived that can differentiate into neurons and glial cells under appropriate neurotrophic factors. The aim of this study was to induce differentiation of hDPSCs into neuroglial phenotypes using retinoic acid (RA) and CSF. The hDPSCs from an impacted third molar were isolated by mechanical and digestion and cultured. The cells have treated by 10(-7) µM RA (RA group) for 8 days, 10% CSF (CSF group) for 8 days and RA with CSF for 8 days (RA/CSF group)...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28705288/chemical-tattoo-treatment-leading-to-systemic-cobalt-hypersensitivity
#9
Nicholas J Zajdel, W Austin Smith, Adam R Taintor, Sharon E Jacob, Edit B Olasz
An otherwise healthy 36-year-old Caucasian woman, without prior history of atopic dermatitis or eczema, presented to an outside dermatologist with a generalized, severely pruritic eruption involving the entire body except the face. One month previously, she had used a 50% trichloroacetic acid tattoo removal solution on a blue-colored tattoo on the medial aspect of the left ankle. The patient's eruption persisted for 7 months, and after several attempts to slowly taper her prednisone dose, she presented to our institution...
2017: Skinmed
https://www.readbyqxmd.com/read/28697878/current-insights-into-the-molecular-genetic-basis-of-dwarfism-in-livestock
#10
REVIEW
Iris J M Boegheim, Peter A J Leegwater, Hein A van Lith, Willem Back
Impairment of bone growth at a young age leads to dwarfism in adulthood. Dwarfism can be categorised as either proportionate, an overall size reduction without changes in body proportions, or disproportionate, a size reduction in one or more limbs, with changes in body proportions. Many forms of dwarfism are inherited and result from structural disruptions or disrupted signalling pathways. Hormonal disruptions are evident in Brooksville miniature Brahman cattle and Z-linked dwarfism in chickens, caused by mutations in GH1 and GHR...
June 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28678965/calcium-hydroxide-associated-with-a-new-vehicle-psidium-cattleianum-leaf-extracts-tissue-response-evaluation
#11
Diego Valentim, Carlos Roberto Emerenciano Bueno, Vanessa Abreu Sanches Marques, Ana Maria Veiga Vasques, Marina Tolomei Sandoval Cury, Luciano Tavares Angelo Cintra, Eloi Dezan
The aim of this study was to evaluate edemogenic activity and subcutaneous inflammatory reaction induced by Psidium cattleianum leaf extracts associated with Ca(OH)2. Thirty male Wistar rats, split equally into three groups [aqueous extract + Ca(OH)2; ethanolic extract + Ca(OH)2; and propylene glycol + Ca(OH)2], were assessed every 3 h or 6 h (five animals in each period). Under general anesthesia, 0.2 mL of 1% Evans blue per 100 g of body weight was injected into the penile vein and each combination to be evaluated was subcutaneously injected into the dorsal region 30 min thereafter...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28666584/-anatomoclinical-study-of-annular-elastolytic-giant-cell-granuloma
#12
F Margerin, B Cribier
BACKGROUND: Annular elastolytic giant cell granuloma (AEGCG), a rare entity first described in 1979, is very similar to O'Brien actinic granuloma (AG), first described in 1975. Since then, many cases have been published under one or other of the two names. We performed a single-centre histopathology study to identify the distinguishing features and determine whether there was any objective difference between AEGCG and AG. PATIENTS AND METHODS: Cases classed as AEGCG or AG at the dermatopathology laboratory in Strasbourg were included and analysed using haematoxylin-eosin, orcein and Alcian blue staining...
June 27, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28665327/green-mind-theory-how-brain-body-behaviour-links-into-natural-and-social-environments-for-healthy-habits
#13
Jules Pretty, Mike Rogerson, Jo Barton
We propose a Green Mind Theory (GMT) to link the human mind with the brain and body, and connect the body into natural and social environments. The processes are reciprocal: environments shape bodies, brains, and minds; minds change body behaviours that shape the external environment. GMT offers routes to improved individual well-being whilst building towards greener economies. It builds upon research on green exercise and nature-based therapies, and draws on understanding derived from neuroscience and brain plasticity, spiritual and wisdom traditions, the lifeways of original cultures, and material consumption behaviours...
June 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28665311/antioxidant-activity-of-yichun-blue-honeysuckle-ybhs-berry-counteracts-ccl%C3%A2-induced-toxicity-in-liver-injury-model-of-mice
#14
Mian-Ying Wang, Madhuwanti Srinivasan, Subramanyam Dasari, Parnal Narvekar, Angela Lincy Prem Antony Samy, Venkata Satish Dontaraju, Lin Peng, Gary L Anderson, Gnanasekar Munirathinam
Yichun Blue Honeysuckle (YBHS) is reported to have a broad range of health benefits including protection against a number of chronic diseases. The objective of our study was to determine whether YBHS exhibits antioxidant activity, and if so, determine how it provides protection against oxidative stress. Eight-week old mice (25 male and 25 female) were randomized into five groups (n = 10 per group). YBHS extract (at 6.25%, 12.5%, or 25%) was administrated via intra-gastric tube to mice at 0.1 mL/10 g body weight once daily for 7 days...
June 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28658416/first-report-of-scuticociliatosis-caused-by-uronema-sp-in-ornamental-reef-fish-imported-into-brazil
#15
Pedro Henrique Magalhães Cardoso, Simone de Carvalho Balian, Eliana Reiko Matushima, Santiago Benites de Pádua, Maurício Laterça Martins
Scuticociliatosis, which is caused by an opportunistic ciliate protozoan, is responsible for significant economic losses in marine ornamental fish. This study reports the occurrence of Uronema sp., which was found to be parasitizing three species of marine reef fish imported into Brazil and maintained in quarantine: Vanderbilt's Chromis (Chromis vanderbilti), blue-green damselfish (Chromis viridis), and sea goldie (Pseudanthias squamipinnis). During the quarantine period, some fish presented with behavioral disorders and hemorrhages and ulcerative lesions on the body surface...
June 22, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28657890/pulmonary-hyalinosis-in-captive-sugar-gliders-petaurus-breviceps
#16
Set A Sokol, Dalen W Agnew, Anne D Lewis, Teresa L Southard, Andrew D Miller
Pulmonary hyalinosis is an idiopathic, typically incidental lesion of old dogs, characterized by multifocal aggregates of epithelioid and multinucleate macrophages that surround periodic acid-Schiff (PAS)-positive hyaline material in airways. Lung lesions resembling pulmonary hyalinosis were observed in 6 captive adult sugar gliders ( Petaurus breviceps; 5 females and 1 male) in a retrospective review of 18 autopsied animals. Clinical signs for 3 of the sugar gliders included lethargy, tachypnea, and dyspnea...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28654049/chondrogenic-pellet-formation-from-cord-blood-derived-induced-pluripotent-stem-cells
#17
Yoojun Nam, Yeri Alice Rim, Ji Hyeon Ju
Human articular cartilage lacks the ability to repair itself. Cartilage degeneration is thus treated not by curative but by conservative treatments. Currently, efforts are being made to regenerate damaged cartilage with ex vivo expanded chondrocytes or bone marrow-derived mesenchymal stem cells (BMSCs). However, the restricted viability and instability of these cells limit their application in cartilage reconstruction. Human induced pluripotent stem cells (hiPSCs) have received scientific attention as a new alternative for regenerative applications...
June 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28647284/the-effects-of-high-intensity-interval-training-on-muscle-size-and-quality-in-overweight-and-obese-adults
#18
Malia N M Blue, Abbie E Smith-Ryan, Eric T Trexler, Katie R Hirsch
OBJECTIVES: Despite growing popularity of high intensity interval training (HIIT) for improving health and fitness, limited data exist identifying the effects of HIIT on muscle characteristics. The purpose of the current study was to investigate the effects of a 3-week HIIT intervention on muscle size and quality in overweight and obese men and women. DESIGN: Randomized controlled trial. METHODS: Forty-four overweight and obese men and women (mean±SD; age: 35...
June 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28645709/aquatic-biodiversity-in-sedimentation-ponds-receiving-road-runoff-what-are-the-key-drivers
#19
Zhenhua Sun, John E Brittain, Ekaterina Sokolova, Helene Thygesen, Svein Jakob Saltveit, Sebastien Rauch, Sondre Meland
Recently, increased attention has been paid to biodiversity conservation provided by blue-green solutions such as engineered ponds that are primarily established for water treatment and flood control. However, little research has been done to analyse the factors that affect biodiversity in such ponds. The purpose of this study was to evaluate the influence of environmental factors on aquatic biodiversity, mainly macroinvertebrate communities, in road sedimentation ponds in order to provide a foundation for recommendations on aquatic biodiversity conservation...
June 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28641681/the-effects-of-training-on-anxiety-and-task-performance-in-simulated-suborbital-spaceflight
#20
Rebecca S Blue, Frederick Bonato, Kimberly Seaton, Andrea Bubka, Johnené L Vardiman, Charles Mathers, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: In commercial spaceflight, anxiety could become mission-impacting, causing negative experiences or endangering the flight itself. We studied layperson response to four varied-length training programs (ranging from 1 h-2 d of preparation) prior to centrifuge simulation of launch and re-entry acceleration profiles expected during suborbital spaceflight. We examined subject task execution, evaluating performance in high-stress conditions. We sought to identify any trends in demographics, hemodynamics, or similar factors in subjects with the highest anxiety or poorest tolerance of the experience...
July 1, 2017: Aerospace Medicine and Human Performance
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