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Angelica sinensis

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https://www.readbyqxmd.com/read/27919656/biotransformation-of-isofraxetin-6-o-%C3%AE-d-glucopyranoside-by-angelica-sinensis-oliv-diels-callus
#1
Di Zhou, Yuhua Zhang, Zhe Jiang, Yue Hou, Kun Jiao, Chunyan Yan, Ning Li
Isofraxetin-6-O-β-d-glucopyranoside, identified from traditional medicinal herbal Xanthoceras sorbifolia Bunge, has been demonstrated to be a natural neuroinflammatory inhibitor. In order to obtain more derivatives with potential anti-neuroinflammatory effects, biotransformation was carried out. According to the characteristics of coumarin skeleton, suspension cultures of Angelica sinensis (Oliv.) Diels callus (A. sinensis callus) were employed because of the presence of diverse phenylpropanoids biosynthetic enzymes...
November 24, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27867268/composition-of-the-essential-oil-from-danggui-zhiqiao-herb-pair-and-its-analgesic-activity-and-effect-on-hemorheology-in-rats-with-blood-stasis-syndrome
#2
Yuanqing Wang, Jianye Yan, Shunxiang Li, Wei Wang, Xiong Cai, Dan Huang, Limin Gong, Xin Li
BACKGROUND: Angelica sinensis and Aurantii fructu used in a pair, named Danggui-Zhiqiao herb-pair (DZHP), which was rich in essential oil and has been adopted to promote blood circulation, dispel blood stasis, and relieve pain in traditional Chinese medicine (TCM). OBJECTIVE: To analyze the composition and pharmacological effects of essential oil from DZHP. MATERIALS AND METHODS: The composition of the essential oil from DZHP was analyzed by gas chromatography/mass spectrometry (GC/MS)...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27827969/comparative-analysis-of-the-effects-of-hydroxysafflor-yellow-a-and-anhydrosafflor-yellow-b-in-safflower-series-of-herb-pairs-using-prep-hplc-and-a-selective-knock-out-approach
#3
Cheng Qu, Lin-Yan Wang, Wen-Tao Jin, Yu-Ping Tang, Yi Jin, Xu-Qin Shi, Li-Li Shang, Er-Xin Shang, Jin-Ao Duan
The flower of Carthamus tinctorius L. (Carthami Flos, safflower), important in traditional Chinese medicine (TCM), is known for treating blood stasis, coronary heart disease, hypertension, and cerebrovascular disease in clinical and experimental studies. It is widely accepted that hydroxysafflor yellow A (HSYA) and anhydrosafflor yellow B (ASYB) are the major bioactive components of many formulae comprised of safflower. In this study, selective knock-out of target components such as HSYA and ASYB by using preparative high performance liquid chromatography (prep-HPLC) followed by antiplatelet and anticoagulation activities evaluation was used to investigate the roles of bioactive ingredients in safflower series of herb pairs...
November 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27827094/effect-of-ferulic-acid-on-the-brain-pharmacokinetics-of-tetramethylpyrazine-in-conscious-rats
#4
Yinai Wu, Fengyun Liao, Weiguo Liao, Jianye Yu, Xingyun Deng, Huazhu Zheng, YingJiao Meng, Lisheng Wang
1. In traditional Chinese medicine, Angelica sinensis is often co-prescribed with Ligusticum chuanxiong Hort for the treatment of ischemic cerebrovascular diseases. Tetramethylpyrazine (TMP) is one of the most important active ingredients isolated from Ligusticum chuanxiong Hort; Ferulic acid (FA) is the main water-soluble component of Angelica sinensis. 2. The purpose of this study was to investigate the possible effect of FA on the brain pharmacokinetics of TMP in conscious Sprague-Dawley rats. The pharmacokinetic parameters of TMP were investigated in brain microdialysates after oral and intravenous administration of TMP (4mg/kg) to rats in the absence and presence of FA (5mg/kg)...
November 9, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27824860/ferulic-acid-orchestrates-anti-oxidative-properties-of-danggui-buxue-tang-an-ancient-herbal-decoction-elucidation-by-chemical-knock-out-approach
#5
Amy G W Gong, Vincent Y Huang, Huai Y Wang, Huang Q Lin, Tina T X Dong, Karl W K Tsim
Ferulic acid, a phenolic acid derived mainly from a Chinese herb Angelica Sinensis Radix (ASR), was reported to reduce the formation of free radicals. Danggui Buxue Tang (DBT), a herbal decoction composing of Astragali Radix (AR) and ASR, has been utilized for more than 800 years in China having known anti-oxidative property. Ferulic acid is a major active ingredient in DBT; however, the role of ferulic acid within the herbal mixture has not been resolved. In order to elucidate the function of ferulic acid within this herbal decoction, a ferulic acid-depleted herbal decoction was created and named as DBTΔfa...
2016: PloS One
https://www.readbyqxmd.com/read/27814708/neuroprotective-effect-of-a-novel-chinese-herbal-decoction-on-cultured-neurons-and-cerebral-ischemic-rats
#6
Fanny Chui-Fun Ip, Yu-Ming Zhao, Kim-Wan Chan, Elaine Yee-Ling Cheng, Estella Pui-Sze Tong, Oormila Chandrashekar, Guang-Miao Fu, Zhong-Zhen Zhao, Nancy Yuk-Yu Ip
BACKGROUND: Historically, traditional Chinese medicine has been widely used to treat stroke. Based on the theory of Chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called Post-Stroke Rehabilitation (PSR), comprising seven herbs - Astragalus membranaceus (Fisch.) Bunge, Salvia miltiorrhiza Bunge, Paeonia lactiflora Pall., Cassia obtusifolia L., Ligusticum chuanxiong Hort., Angelica sinensis (Oliv.) Diels, and Glycyrrhiza uralensis Fisch...
November 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27813540/protective-effects-of-angelica-sinensis-polysaccharide-against-hyperglycemia-and-liver-injury-in-multiple-low-dose-streptozotocin-induced-type-2-diabetic-balb-c-mice
#7
Kaiping Wang, Zhuohong Tang, Ziming Zheng, Peng Cao, Weizhi Shui, Qiang Li, Yu Zhang
Angelica sinensis polysaccharide (ASP), one of the major active ingredients isolated from the roots of Angelica sinensis (Oliv.) Diels, possesses numerous bioactivities. The aim of the present study was to explore the mechanisms of ASP-mediated hypoglycemic effects in type 2 diabetic BALB/c mice induced by multiple low-dose streptozotocin (STZ) injections plus a long-term high-fat diet (HFD) feeding. The potential mechanism explicating the hepatoprotective effect was also considered. Specifically, serum and hepatic biochemical parameters were determined, as well as the key proteins involved in glucose metabolism and apoptosis...
November 4, 2016: Food & Function
https://www.readbyqxmd.com/read/27807897/polysaccharide-of-danggui-buxue-tang-an-ancient-chinese-herbal-decoction-induces-expression-of-pro-inflammatory-cytokines-possibly-via-activation-of-nf%C3%AE%C2%BAb-signaling-in-cultured-raw-264-7-cells
#8
Amy Gw Gong, Laura Ml Zhang, Candy Tw Lam, Miranda L Xu, Huai Y Wang, H Q Lin, Tina Tx Dong, Karl Wk Tsim
Danggui Buxue Tang (DBT) is an ancient Chinese herbal decoction containing two herbs, Astragali Radix (AR) and Angelicae Sinensis Radix (ASR): this herbal decoction serves as dietary supplement for women during menopause. DBT has been known to modulate immune responses, and its polysaccharide is proposed to be one of the active components. However, the polysaccharide-induced signaling in immune activation is not revealed. Here, we are identifying that the immune activation, triggered by DBT, could be mediated by polysaccharide...
November 3, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27785882/naoxintong-attenuates-ischaemia-reperfusion-injury-through-inhibiting-nlrp3-inflammasome-activation
#9
Yaqiong Wang, Xiaoxiang Yan, Shouling Mi, Zhang Li, Yuexiang Wang, Hong Zhu, Xiaolei Sun, Buchang Zhao, Chao Zhao, Yunzeng Zou, Kai Hu, Xiaoqiang Ding, Aijun Sun, Junbo Ge
Naoxintong (NXT) is a Chinese Materia Medica standardized product extracted from 16 various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica sinensis, Astragali Radix. Naoxintong is clinically effective in treating ischaemia heart disease. Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome has been critically involved in myocardial ischaemia/reperfusion (I/R) injury. Here, we have been suggested that NXT might attenuate myocardial I/R injury via suppression of NLRP3 inflammasome activation...
October 26, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27785106/effects-of-a-new-combination-of-nutraceuticals-on-postmenopausal-symptoms-and-metabolic-profile-a-crossover-randomized-double-blind-trial
#10
Valentina Trimarco, Francesco Rozza, Raffaele Izzo, Vincenzo De Leo, Valentina Cappelli, Carla Riccardi, Costantino Di Carlo
OBJECTIVES: This study was designed to measure the beneficial effects of a combination of nutraceutics (NUT; AkP04, Morestril(®), Akademy Pharma) containing soy isoflavones (80 mg), dry extract of Angelica sinensis (50 mg), dry extract of Morus alba leaf (200 mg) and magnesium (56.25 mg) in the relief of somatic, psychological, and urogenital symptoms in postmenopausal patients, using the validated Menopause Rating Scale (MRS) and cardiovascular risk factors. MATERIALS AND METHODS: A total of 43 symptomatic postmenopausal women (MRS ≥20) were enrolled in a crossover trial...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27772541/bone-marrow-stromal-cells-combined-with-sodium-ferulate-and-n-butylidenephthalide-promote-the-effect-of-therapeutic-angiogenesis-via-advancing-astrocyte-derived-trophic-factors-after-ischemic-stroke
#11
Qian Zhang, Zhen-Wei Chen, Yong-Hua Zhao, Bo-Wen Liu, Nai-Wei Liu, Chien-Chih Ke, Hong-Mei Tan
Being a potential candidate for stroke treatment, bone marrow stromal cells (BMSCs) have been demonstrated to be able to enhance angiogenesis and proliferation of reactive astrocytes which subsequently lead to the amelioration of neurological injury. Increasing evidences further indicate combined BMSCs with certain agent such as simvastatin may have improved therapeutic effect. Sodium Ferulate (SF) and n-butylidenephthalide (BP), two main components of Radix Angelica Sinensis, are proved to be the important regulators of stem cells in cell migration, differentiation and pluripotency maintenance...
October 21, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27723532/green-tea-cammellia-sinensis-attenuates-ventricular-remodeling-after-experimental-myocardial-infarction
#12
Beatriz B Lustosa, Bertha Polegato, Marcos Minicucci, Bruna Rafacho, Priscila P Santos, Ana Angélica Fernandes, Katashi Okoshi, Diego Batista, Pamela Modesto, Andrea Gonçalves, Elenize J Pereira, Vanessa Pires, Sergio Paiva, Leonardo Zornoff, Paula S Azevedo
BACKGROUND: Considering the high morbidity and mortality after myocardial infarction (MI), the study of compounds with potential benefits for cardiac remodeling is reasonable. Green tea (GT) (Cammellia sinensis) is the most consumed beverage in the world. The potential action mechanisms of GT include anti-inflammatory, anti-apoptotic, antioxidant, and lipid-lowering properties. OBJECTIVE: This study analyzed the effects of GT on cardiac remodeling following coronary occlusion in rats...
December 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27713564/a-nucleotide-signature-for-the-identification-of-angelicae-sinensis-radix-danggui-and-its-products
#13
Xiaoyue Wang, Yang Liu, Lili Wang, Jianping Han, Shilin Chen
It is very difficult to identify Angelicae sinensis radix (Danggui) when it is processed into Chinese patent medicines. The proposed internal transcribed spacer 2 (ITS2) is not sufficient to resolve heavily processed materials. Therefore, a short barcode for the identification of processed materials is urgently needed. In this study, 265 samples of Angelicae sinensis radix and adulterants were collected. The ITS2 region was sequenced, and based on one single nucleotide polymorphism(SNP) site unique to Angelica sinensis, a nucleotide signature consisting of 37-bp (5'-aatccgcgtc atcttagtga gctcaaggac ccttagg-3') was developed...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27677719/botanicals-and-their-bioactive-phytochemicals-for-women-s-health
#14
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/27673369/web-server-for-peak-detection-baseline-correction-and-alignment-in-two-dimensional-gas-chromatography-mass-spectrometry-based-metabolomics-data
#15
Tze-Feng Tian, San-Yuan Wang, Tien-Chueh Kuo, Cheng-En Tan, Guan-Yuan Chen, Ching-Hua Kuo, Chi-Hsin Sally Chen, Chang-Chuan Chan, Olivia A Lin, Y Jane Tseng
Two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC/TOF-MS) is superior for chromatographic separation and provides great sensitivity for complex biological fluid analysis in metabolomics. However, GC×GC/TOF-MS data processing is currently limited to vendor software and typically requires several preprocessing steps. In this work, we implement a web-based platform, which we call GC(2)MS, to facilitate the application of recent advances in GC×GC/TOF-MS, especially for metabolomics studies...
October 13, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27642354/the-antidepressant-effect-of-angelica-sinensis-extracts-on-chronic-unpredictable-mild-stress-induced-depression-is-mediated-via-the-upregulation-of-the-bdnf-signaling-pathway-in-rats
#16
Jun Shen, Junjian Zhang, Min Deng, Yue Liu, Yuan Hu, Lei Zhang
Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive impairments. However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress- (CUMS-) induced depression in rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27641605/post-hematopoietic-stem-cell-transplantation-in-patients-with-hematologic-disorders-chinese-herbal-medicine-for-an-unmet-need
#17
REVIEW
Tom Fleischer, Tung-Ti Chang, Hung-Rong Yen
While much progress has been made in the field of hematopoietic stem cell transplantation (HSCT), headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine (CHM) for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention...
September 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27586474/differentially-expressed-genes-in-heads-and-tails-of-angelica-sinensis-diels-focusing-on-ferulic-acid-metabolism
#18
Jie Yang, Wei-Hong Li, Rong An, Yi-Li Wang, Yan Xu, Jie Chen, Xiao-Fang Wang, Xiao-Bo Zhang, Jing Li, Wei-Jun Ding
OBJECTIVE: To explore the scientific connotation of the discrepant pharmaceutical activities between the head and tail of Angelica sinensis diels (AS), an important herb extensively utilized in Chinese medicine, by the approach of transcriptome sequencing. METHODS: Ten samples of AS were randomly collected in Min County, Gansu Province of China. Transcriptome sequencing of AS was accomplished in a commercial ILLumina HiSeq-2000 platform. The transcriptome of each head and tail of AS were fifixed in a gene chip, and detected under the procedure of Illumina HiSeq-2000...
September 1, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27510280/chemiluminescence-of-nitrogen-rich-quantum-dots-in-diperiodatoargentate-iii-solution-and-its-application-in-ferulic-acid-analysis
#19
Zhaofu Fu, Gongke Li, Yufei Hu
A novel chemiluminescence (CL) system based on the reaction of fluorescent water-soluble nitrogen-rich quantum dots (N-dots) and diperiodatoargentate(III) (DPA) was developed. The prepared N-dots have a small size (≤10 nm) and high percentage of nitrogen (39.9 %), which exceeds the content of carbon in the same N-dots. The N-dots exhibit characteristic blue fluorescence under UV light and up-conversion luminescence. The relatively intense CL emission is based on the direct oxidation of N-dots by DPA. The CL emission may be attributed to the high nitrogen content and the special structure of the N-dots...
December 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27497636/protective-effects-of-the-roots-of-angelica-sinensis-on-strenuous-exercise-induced-sports-anemia-in-rats
#20
Chih-Wei Chang, Yi-Ming Chen, Yi-Ju Hsu, Chi-Chang Huang, Yu-Tse Wu, Mei-Chich Hsu
ETHNOPHARMACOLOGICAL RELEVANCE: Sports anemia is a persistent and severe problem in athletes owing to strenuous exercise-induced oxidative stress and hepcidin upregulation. The roots of Angelica sinensis (AS), a familiar traditional Chinese medicine, has been used for replenishing blood since antiquity. AIM OF THE STUDY: To evaluate the effects of ethanolic AS extract in a 4-week study on sports anemia in female Wistar rats. MATERIALS AND METHODS: To induce anemia, a strenuous exercise protocol consisting of running and swimming was employed with increasing intensity...
August 3, 2016: Journal of Ethnopharmacology
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