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https://www.readbyqxmd.com/read/29766171/electron-donor-and-acceptor-functionalized-dithienylethenes-effects-of-charge-density-on-photochromic-properties
#1
Hao Wan, Haodong Xue, Yuan Ling, Yanjun Qiao, Yijing Chen, Gang Zhou
Electron-donating triphenylamine and/or electron-withdrawing pyromellitic diimide (PMDI) are functionalized on dithienylethene (DTE) and three novel photochromic materials have been designed and successfully synthesized. All the compounds display reversible photochromism due to the molecular switching between ring-closed isomers upon UV light irradiation and ring-open isomers upon exposure to visible light. Thus they can be applied as an anti-counterfeiting ink. Moreover, the study of the photoswitching kinetics reveals that both the ring-closing and ring-opening reactions are first-order reactions...
May 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29765201/deposition-and-transport-of-linezolid-mediated-by-a-synthetic-surfactant-synsurf-%C3%A2-within-a-pressurized-metered-dose-inhaler-a-calu-3-model
#2
Lyné van Rensburg, Johann M van Zyl, Johan Smith
Background: Previous studies in our laboratory demonstrated that a synthetic peptide containing lung surfactant enhances the permeability of chemical compounds through bronchial epithelium. The purpose of this study was to test two formulations of Synsurf® combined with linezolid as respirable compounds using a pressurized metered dose inhaler (pMDI). Methods: Aerosolization efficiency of the surfactant-drug microparticles onto Calu-3 monolayers as an air interface culture was analyzed using a Next Generation Impactor™...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29702166/development-of-high-performance-biodegradable-rigid-polyurethane-foams-using-all-bioresource-based-polyols-lignin-and-soy-oil-derived-polyols
#3
Xiaogang Luo, Yuqin Xiao, Qiangxian Wu, Jian Zeng
Development of biodegradable polyurethane materials is the most promising in the wider context of the "greening" of industrial chemistry. To tackle this challenge, a novel biodegradable polyurethane foam from all bioresource-based polyols (lignin and soy oil-derived polyols) and polymeric methyldiphenyl diisocyanate (pMDI) have been synthesized via a one-pot and self-rising process. All these foam samples have the internal cellular morphology and microstructure. FTIR result exhibits characteristic peaks of polyurethane, and indicates covalent bonds between soy-based polyurethane and lignin, and the lignin powders can react with pMDI via active -H and -CNO...
April 24, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29462195/assessment-of-inhalation-flow-patterns-of-soft-mist-inhaler-co-prescribed-with-dry-powder-inhaler-using-inspiratory-flow-meter-for-multi-inhalation-devices
#4
Daiki Hira, Hiroyoshi Koide, Shigemi Nakamura, Toyoko Okada, Kazunori Ishizeki, Masafumi Yamaguchi, Setsuko Koshiyama, Tetsuya Oguma, Kayoko Ito, Saori Funayama, Yuko Komase, Shin-Ya Morita, Kohshi Nishiguchi, Yasutaka Nakano, Tomohiro Terada
The patients' inhalation flow pattern is one of the significant determinants for clinical performance of inhalation therapy. However, the development of inhalation flow meters for various inhalation devices has been unable to keep up with the increasing number of newly launched inhalation devices. In the present study, we developed simple attachment orifices for the inhalation flow pattern monitoring system, which are suitable for all commercial inhalers, and investigated the efficacy of the system on the clinical inhalation instruction for patients co-prescribed dry powder inhaler (DPI) and soft mist inhaler (SMI)...
2018: PloS One
https://www.readbyqxmd.com/read/29428382/invitro-evaluation-of-optimal-inhalation-flow-patterns-for-commercial-dry-powder-inhalers-and-pressurized-metered-dose-inhalers-with-human-inhalation-flow-pattern-simulator
#5
Daiki Hira, Tomoyuki Okuda, Ayano Mizutani, Nao Tomida, Hirokazu Okamoto
This study aimed at developing a novel analytical method to identify optimal inhalation flow patterns for commercial dry powder inhalers (DPIs) and pressurized metered dose inhalers (pMDIs). As typical commercial DPI and pMDI, Pulmicort® Turbuhaler® , and Sultanol® Inhaler were evaluated by an in vitro inhalation performance testing system with a flow pattern simulator. An 8-stage Andersen cascade impactor (ACI) or twin stage liquid impinger (TSLI) was applied to determine the inhalation performance. The peak flow rate (PFR) of the inhalation flow pattern was set from 15 to 80 L/min in reference to our previous study...
February 8, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29415579/use-of-spacers-for-patients-treated-with-pressurized-metered-dose-inhalers-focus-on-the-ventolin%C3%A2-mini-spacer
#6
Gregor Anderson, Neil Johnson, Aruni Mulgirigama, Bhumika Aggarwal
Spacers offer a multitude of benefits by reducing the requirement to coordinate inhalation with actuation and improving inhaler technique in patients using a pressurized metered dose inhaler (pMDI). Spacers improve drug targeting by retaining within the spacer large particles normally deposited in the oropharynx, and by creating a prolonged aerosol cloud of fine particles to give the user increased time to inhale after actuation. This is particularly important in young children and the elderly to effectively deliver medication to the airways...
April 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29414447/physical-ability-of-people-with-rheumatoid-arthritis-and-age-sex-matched-controls-to-use-four-commonly-prescribed-inhaler-devices
#7
Yasmin Kafaei Shirmanesh, Matthew D Jones
BACKGROUND: Respiratory disease is a common co-morbidity with rheumatoid arthritis (RA). RA commonly affects the hands, but there is little research investigating whether these patients are physically able to operate inhalers. AIM: To compare the physical ability of people with and without RA to use four commonly prescribed inhaler devices (pressurised metered dose inhaler (pMDI), Easi-Breathe® , HandiHaler® and Turbohaler® ). METHODS: Adults with RA and an equal number of age-sex matched controls were observed using placebo inhaler devices...
February 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29413503/co-suspension-delivery-technology-in-pressurized-metered-dose-inhalers-for-multi-drug-dosing-in-the-treatment-of-respiratory-diseases
#8
REVIEW
Gary T Ferguson, Anthony J Hickey, Sarvajna Dwivedi
Technologies for long-term delivery of aerosol medications in asthma and chronic obstructive pulmonary disease have improved over the past 2 decades with advancements in our understanding of the physical chemistry of aerosol formulations, device engineering, aerosol physics, and pulmonary biology. However, substantial challenges remain when a patient is required to use multiple inhaler types, multiple medications, and/or combinations of medications. Combining multiple drugs into a single inhaler while retaining appropriate dosing of the individual agents in the combination may enhance patient adherence to therapy and reduce device errors that occur when patients are using multiple inhalers...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29409488/the-topical-study-of-inhaled-drug-salbutamol-delivery-in-idiopathic-pulmonary-fibrosis
#9
Omar S Usmani, Martyn F Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K Simpson, William A Fahy, Richard P Marshall, Pauline T Lukey, Toby M Maher
BACKGROUND: Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF). METHODS: The TOPICAL study was a 4-period, partially-randomised, controlled, crossover study to investigate four aerosolised approaches in IPF subjects. Nine subjects were randomised to receive 99m Technetium-labelled monodisperse salbutamol (1.5 μm or 6 μm; periods 1 and 2). Subjects also received radio-labelled salbutamol using a polydisperse nebuliser (period 3) and unlabelled salbutamol (400 μg) using a polydisperse pressurized metered dose inhaler with volumatic spacer (pMDI; period 4)...
February 6, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29391489/objective-assessment-of-patient-inhaler-user-technique-using-an-audio-based-classification-approach
#10
Terence E Taylor, Yaniv Zigel, Clarice Egan, Fintan Hughes, Richard W Costello, Richard B Reilly
Many patients make critical user technique errors when using pressurised metered dose inhalers (pMDIs) which reduce the clinical efficacy of respiratory medication. Such critical errors include poor actuation coordination (poor timing of medication release during inhalation) and inhaling too fast (peak inspiratory flow rate over 90 L/min). Here, we present a novel audio-based method that objectively assesses patient pMDI user technique. The Inhaler Compliance Assessment device was employed to record inhaler audio signals from 62 respiratory patients as they used a pMDI with an In-Check Flo-Tone device attached to the inhaler mouthpiece...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378477/a-review-of-the-in-vitro-and-in-vivo-valved-holding-chamber-vhc-literature-with-a-focus-on-the-aerochamber-plus-flow-vu-anti-static-vhc
#11
Sanjeeva Dissanayake, Jason Suggett
Valved holding chambers (VHCs) reduce the need for inhalation-actuation coordination with pressurized metered dose inhalers (pMDIs), reduce oropharyngeal drug deposition and may improve lung deposition and clinical outcomes compared to pMDIs used alone. While VHCs are thus widely advocated for use in vulnerable patient groups within clinical and regulatory guidelines, there is less consensus as to whether the performance differences between different VHCs have clinical implications. This review evaluates the VHC literature, in particular the data pertaining to large- versus small-volume chambers, aerosol performance with a VHC adjunct versus a pMDI alone, charge dissipative/conducting versus non-conducting VHCs, and facemasks, to ascertain whether potentially meaningful differences between VHCs exist...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29355645/errors-in-the-use-of-inhalers-by-health-care-professionals-a-systematic-review
#12
Vicente Plaza, Jordi Giner, Gustavo J Rodrigo, Myrna B Dolovich, Joaquin Sanchis
BACKGROUND: Inefficient inhaler technique (IT) compromises the optimal delivery of medication. However, the IT knowledge of health care professionals (HCPs) has received scant attention. OBJECTIVE: The objective of this study was to perform a systematic review of published reports assessing the IT proficiency of HCPs in using pressurized metered dose (pMDI) and dry powder (DPI) inhalers. METHODS: Studies published between 1975 and 2014 that directly assessed the IT skills of HCPs were selected according to predefined selection criteria...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29317923/identification-of-inhaler-technique-errors-with-a-routine-procedure-in-portuguese-community-pharmacy
#13
M Margarida Castel-Branco, Ana Fontes, Isabel V Figueiredo
Background: A correct selection of drugs prescribed, but also the choice of the appropriate inhaler device, is crucial for the control of respiratory diseases. Objective: To evaluate the inhaler technique and identify potential errors of patients when treated with inhalers by testing a routinary procedure to be implemented in any community pharmacy. Methods: Adults with asthma/COPD and under inhalation therapy were invited to demonstrate how they use their inhalers...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29316592/the-addition-of-diclofenac-to-a-multimodal-pain-control-regimen-decreases-postoperative-pain-and-opioid-consumption
#14
Nicole E George, Cheryle Gurk-Turner, Jennifer I Etcheson, Chukwuweike U Gwam, Randal De Souza, Spencer S Smith, James Nace, Ronald E Delanois
INTRODUCTION: Total knee arthroplasty (TKA) is a commonly-performed orthopaedic procedure in the United States. However, inadequate postoperative pain management following TKA has been associated with a number of negative consequences, including chronic postoperative pain requiring long-term opioid use. Multimodal pain control is a recently-popularized means of maximizing analgesia and postoperative outcomes. We aimed to evaluate the outcomes of a multimodal pain regimen incorporating diclofenac, including: 1) length of stay (LOS); 2) pain intensity; and 3) opioid consumption in primary TKA patients...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29274305/treatment-adherence-and-level-of-control-in-moderate-persistent-asthma-in-children-and-adolescents-treated-with-fluticasone-and-salmeterol
#15
Nulma S Jentzsch, Gabriela C G Silva, Guilherme M S Mendes, Paul L P Brand, Paulo Camargos
OBJECTIVE: There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children. METHODS: This was a prospective observational study of 84 patients aged 5-16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000μg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment...
December 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29237699/single-inhaler-triple-therapy-for-copd
#16
(no author information available yet)
The European Medicines Agency (EMA) has granted marketing authorisation for a pressurised metered dose inhaler (pMDI) containing beclometasone dipropionate, formoterol fumarate dihydrate and glycopyrronium bromide (Trimbow - Chiesi Pharmaceuticals) for the treatment of chronic obstructive pulmonary disease (COPD) in patients not adequately treated with a combination of an inhaled corticosteroid (ICS) and a long-acting beta2 agonist (LABA).1-3 The manufacturer claims that this is a significant treatment advance for COPD patients, and that the use of one inhaler should simplify therapy and, therefore, may improve adherence...
December 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29229103/effect-of-budesonide-formoterol-pressurized-metered-dose-inhaler-on-exacerbations-versus-formoterol-in-chronic-obstructive-pulmonary-disease-the-6-month-randomized-rise-revealing-the-impact-of-symbicort-in-reducing-exacerbations-in-copd-study
#17
Gary T Ferguson, Donald P Tashkin, Tor Skärby, Carin Jorup, Kristina Sandin, Michael Greenwood, Kristine Pemberton, Frank Trudo
BACKGROUND: Prevention of exacerbations is a primary goal for chronic obstructive pulmonary disease (COPD) therapy. This randomized, double-blind, double-dummy, parallel-group, multicenter study evaluated the effect of budesonide/formoterol pressurized metered-dose inhaler (pMDI) versus formoterol dry powder inhaler (DPI) on reducing COPD exacerbations. METHODS: 1219 patients aged ≥40 years with moderate-to-very-severe COPD (per lung function) and a history of ≥1 COPD exacerbation received budesonide/formoterol pMDI 320/9 μg twice daily (BID) during a 4-week run-in...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29185812/brand-and-generic-use-of-inhalation-medication-and-frequency-of-switching-in-children-and-adults-a-population-based-cohort-study
#18
Marjolein Engelkes, Jan C van Blijderveen, Jetty A Overbeek, Josephine Kuiper, Ron C M Herings, Miriam C J M Sturkenboom, Johan C de Jongste, Katia M C Verhamme, Hettie M Janssens
BACKGROUND: The expiration of patents of brand inhalation medications and the ongoing pressure on healthcare budgets resulted in a growing market for generics. AIM: To study the use of brand and generic inhalation medication and the frequency of switching between brand and generic and between devices. In addition, we investigated whether switching affected adherence. METHODS: From dispensing data from the Dutch PHARMO Database Network a cohort aged ≥ 5 years, using ≥ 1 year of inhalation medication between 2003 and 2012 was selected...
November 29, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29162718/delay-between-shaking-and-actuation-of-a-hydrofluoroalkane-fluticasone-pressurized-metered-dose-inhaler
#19
Ariel Berlinski, Dirk von Hollen, John N Pritchard, Ross Hm Hatley
BACKGROUND: Inhaled corticosteroids are used to treat pediatric asthma. The shaking of a pressurized metered-dose inhaler (pMDI) is required to ensure consistency of emitted dose. Delays between shaking and actuating the pMDI are frequent during administration of aerosols to children where a valved holding chamber is used. METHODS: In a recent clinical trial, we used a monitoring device to record shaking and actuation of the pMDI and the inhalation profiles of children with asthma while they were inhaling fluticasone hydrofluoroalkane from a valved holding chamber onto an external filter...
March 2018: Respiratory Care
https://www.readbyqxmd.com/read/29117514/investigating-cascade-impactor-performance-using-a-modified-3d-printed-induction-port
#20
Kai Berkenfeld, Michael Bernauer, Jason T McConville, Alf Lamprecht
Based on a computer tomographic scan of a human trachea, a modified induction port (mIP), for use with the Next Generation Cascade Impactor, was manufactured using 3D printing technology. Standard United States Pharmacopoeia IP (USPIP) was compared to the mIP and a 3D printed version of the USPIP (USP3DIP) by analyzing different types of commercial salbutamol formulations for inhalation. Increased retention of particles in the mIP was found analyzing a pMDI formulation, leading to a decrease in the FPF from 28...
January 15, 2018: International Journal of Pharmaceutics
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