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https://www.readbyqxmd.com/read/29780445/a-comparison-of-simulated-and-field-derived-leaf-area-index-lai-and-canopy-height-values-from-four-forest-complexes-in-the-southeastern-usa
#1
John S Iiames, Ellen Cooter, Donna Schwede, Jimmy Williams
Vegetative leaf area is a critical input to models that simulate human and ecosystem exposure to atmospheric pollutants. Leaf area index (LAI) can be measured in the field or numerically simulated, but all contain some inherent uncertainty that is passed to the exposure assessments that use them. LAI estimates for minimally managed or natural forest stands can be particularly difficult to develop as a result of interspecies competition, age and spatial distribution. Satellite-based LAI estimates hold promise for retrospective analyses, but we must continue to rely on numerical models for alternative management analysis...
2018: Forests
https://www.readbyqxmd.com/read/29778134/central-serous-chorioretinopathy-in-african-americans-at-wilmer-eye-institute
#2
Pooja H Mehta, Jay Chhablani, Jiangxia Wang, Catherine B Meyerle
OBJECTIVE: To evaluate the frequency of central serous chorioretinopathy (CSC) in African Americans/blacks within an academic center in a predominantly African American city, as the current belief is that CSC is rare in this population. METHODS: A retrospective review of all patients' charts diagnosed with CSC at Wilmer Eye Institute/Johns Hopkins University from August 2009-August 2015 was conducted via an electronic health record search (EPIC). The charts were categorized by self-reported race and gender...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29761424/dietary-intake-of-total-polyphenol-and-polyphenol-classes-and-the-risk-of-colorectal-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort
#3
Raul Zamora-Ros, Valerie Cayssials, Mazda Jenab, Joseph A Rothwell, Veronika Fedirko, Krasimira Aleksandrova, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Marie-Christine Boutron-Ruault, Franck Carbonnel, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elissavet Valanou, Effie Vasilopoulou, Giovanna Masala, Valeria Pala, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Elisabete Weiderpass, Marko Lukic, Torkjel M Sandanger, Cristina Lasheras, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Bodil Ohlsson, Lena Maria Nilsson, Martin Rutegård, Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Kathryn Bradbury, Heinz Freisling, Isabelle Romieu, Amanda J Cross, Paolo Vineis, Augustin Scalbert
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries...
May 15, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29761319/gaussian-graphical-models-identified-food-intake-networks-and-risk-of-type-2-diabetes-cvd-and-cancer-in-the-epic-potsdam-study
#4
Khalid Iqbal, Lukas Schwingshackl, Anna Floegel, Carolina Schwedhelm, Marta Stelmach-Mardas, Clemens Wittenbecher, Cecilia Galbete, Sven Knüppel, Matthias B Schulze, Heiner Boeing
PURPOSE: The aim of the study was to investigate the association between the previously identified Gaussian graphical models' (GGM) food intake networks and risk of major chronic diseases as well as intermediate biomarkers in the European Prospective Investigation into Cancer and nutrition (EPIC)-Potsdam cohort. METHODS: In this cohort analysis of 10,880 men and 13,340 women, adherence to the previously identified sex-specific GGM networks as well as principal component analysis identified patterns was investigated in relation to risk of major chronic diseases, using Cox-proportional hazard models...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29759646/quantification-of-38-dietary-polyphenols-in-plasma-by-differential-isotope-labelling-and-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#5
David Achaintre, Audrey Gicquiau, Liang Li, Sabina Rinaldi, Augustin Scalbert
Polyphenols constitute one of the most complex classes of phytochemicals in the human diet and have been suggested to play a role in the prevention of chronic diseases such as cardiovascular diseases, diabetes and cancers. However, evidence from epidemiological studies is still needed to better understand their role in disease prevention. To do so, robust methods for the accurate measurement of these molecules in large series of samples are needed. We report here the development of a highly-sensitive method based on differential isotope labelling with 13 C- and 12 C-dansyl chloride for the analysis of 38 structurally diverse polyphenols in 50 μL plasma by tandem mass spectrometry with limits of quantification varying between 0...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29746298/perinatally-acquired-hiv-infection-accelerates-epigenetic-aging-in-south-african-adolescents
#6
Steve Horvath, Nicole Phillips, Sarah J Heany, Michael S Kobor, David Ts Lin, Landon Myer, Heather J Zar, Dan J Stein, Andrew J Levine, Jacqueline Hoare
OBJECTIVE: Recent studies demonstrate that infection with the Human Immunodeficiency Virus-1 (HIV) is associated with accelerated aging effects in adults according to a highly accurate epigenetic biomarker of aging known as epigenetic clock. However, it not yet known whether epigenetic age acceleration occurs as early as adolescence in perinatally HIV-infected (PHIV+) youth. DESIGN: Observational study of PHIV and HIV-uninfected adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort (CTAAC) Study...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29717489/influence-of-a-cancer-diagnosis-on-changes-in-fruit-and-vegetable-consumption-according-to-cancer-site-stage-at-diagnosis-and-socioeconomic-factors-results-from-the-large-e3n-epic-study
#7
Aurélie Affret, Mathilde His, Gianluca Severi, Francesca Romana Mancini, Patrick Arveux, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi
Many studies have demonstrated that lifestyle factors, including diet, may influence cancer survival. The number of cancer survivors is increasing worldwide and little is known about long-term diet changes in people who had cancer. We studied 53 981 women from the prospective E3N-EPIC cohort study with available dietary data in 1993 and 2005, among whom 4 619 had a cancer diagnosis inbetween (including n=2 699 breast cancers). We evaluated the potential impact of a cancer diagnosis (comparing women with cancer to women with no cancer) on changes in FV consumption using multivariable linear regression models considering cancer site, stage at diagnosis, and socioeconomic factors...
May 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29707771/nonsteroidal-anti-inflammatory-drug-use-and-breast-cancer-risk-in-a-european-prospective-cohort-study
#8
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra H M Peeters, Carla H Van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29699034/-association-between-obesity-and-dna-methylation-among-the-7-16-year-old-twins
#9
C X Li, Y Gao, W J Gao, C Q Yu, J Lyu, R R Lyu, J L Duan, Y Sun, X H Guo, S F Wang, B Zhou, G Wang, W H Cao, L M Li
Objective: On whole-genome scale, we tried to explore the correlation between obesity-related traits and DNA methylation sites, based on discordant monozygotic twin pairs. Methods: A total of 90 pairs of 6-17 year-old twins were recruited in Chaoyang district, Yanqing district and Fangshan district in Beijing in 2016. Information on twins was gathered through a self-designed questionnaire and results: from physical examination, including height, weight and waist circumference of the subjects under study. DNA methylation detection was chosen on the Illumina Human Methylation EPIC BeadChip...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29676281/risk-thresholds-for-alcohol-consumption-combined-analysis-of-individual-participant-data-for-599-912-current-drinkers-in-83-prospective-studies
#10
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank)...
April 14, 2018: Lancet
https://www.readbyqxmd.com/read/29665866/mitochondrial-dna-copy-number-variation-leukocyte-telomere-length-and-breast-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#11
Daniele Campa, Myrto Barrdahl, Aurelia Santoro, Gianluca Severi, Laura Baglietto, Hanane Omichessan, Rosario Tumino, H B As Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Antonio Agudo, Marc Gunter, Laure Dossus, Vittorio Krogh, Giuseppe Matullo, Antonia Trichopoulou, Ruth C Travis, Federico Canzian, Rudolf Kaaks
BACKGROUND: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC). METHODS: To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number in up to 570 BC cases and 538 controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
April 17, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29650484/identification-of-new-tools-to-predict-surgical-performance-of-novices-using-a-plastic-surgery-simulator
#12
Roy Kazan, Alex Viezel-Mathieu, Shantale Cyr, Thomas M Hemmerling, Samuel J Lin, Mirko S Gilardino
OBJECTIVE: To identify new tools capable of predicting surgical performance of novices on an augmentation mammoplasty simulator. The pace of technical skills acquisition varies between residents and may necessitate more time than that allotted by residency training before reaching competence. Identifying applicants with superior innate technical abilities might shorten learning curves and the time to reach competence. The objective of this study is to identify new tools that could predict surgical performance of novices on a mammoplasty simulator...
April 9, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29622527/epic-allies-a-gamified-mobile-phone-app-to-improve-engagement-in-care-antiretroviral-uptake-and-adherence-among-young-men-who-have-sex-with-men-and-young-transgender-women-who-have-sex-with-men-protocol-for-a-randomized-controlled-trial
#13
Sara LeGrand, Kathryn E Muessig, Alyssa Platt, Karina Soni, Joseph R Egger, Nkechinyere Nwoko, Tobias McNulty, Lisa B Hightow-Weidman
BACKGROUND: In the United States, young men who have sex with men (YMSM) and transgender women who have sex with men (YTWSM) bear a disproportionate burden of prevalent and incident HIV infections. Once diagnosed, many YMSM and YTWSM struggle to engage in HIV care, adhere to antiretroviral therapy (ART), and achieve viral suppression. Computer-based interventions, including those focused on behavior change, are recognized as effective tools for engaging youth. OBJECTIVE: The purpose of the study described in this protocol is to evaluate the efficacy of Epic Allies, a theory-based mobile phone app that utilizes game mechanics and social networking features to improve engagement in HIV care, ART uptake, ART adherence, and viral suppression among HIV-positive YMSM and YTWSM...
April 5, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29620962/addressing-social-determinants-of-health-case-studies-from-epic-s-population-health-steering-board
#14
Peter Roberts, Cynthia Deculus, Lawrence Garber, Antti Iivanainen, Torben Stentoft, Krischa Winright
No abstract text is available yet for this article.
April 5, 2018: Population Health Management
https://www.readbyqxmd.com/read/29615487/comparison-of-prognostic-models-to-predict-the-occurrence-of-colorectal-cancer-in-asymptomatic-individuals-a-systematic-literature-review-and-external-validation-in-the-epic-and-uk-biobank-prospective-cohort-studies
#15
Todd Smith, David C Muller, Karel G M Moons, Amanda J Cross, Mattias Johansson, Pietro Ferrari, Guy Fagherazzi, Petra H M Peeters, Gianluca Severi, Anika Hüsing, Rudolf Kaaks, Anne Tjonneland, Anja Olsen, Kim Overvad, Catalina Bonet, Miguel Rodriguez-Barranco, Jose Maria Huerta, Aurelio Barricarte Gurrea, Kathryn E Bradbury, Antonia Trichopoulou, Christina Bamia, Philippos Orfanos, Domenico Palli, Valeria Pala, Paolo Vineis, Bas Bueno-de-Mesquita, Bodil Ohlsson, Sophia Harlid, Bethany Van Guelpen, Guri Skeie, Elisabete Weiderpass, Mazda Jenab, Neil Murphy, Elio Riboli, Marc J Gunter, Krasimira Jekova Aleksandrova, Ioanna Tzoulaki
OBJECTIVE: To systematically identify and validate published colorectal cancer risk prediction models that do not require invasive testing in two large population-based prospective cohorts. DESIGN: Models were identified through an update of a published systematic review and validated in the European Prospective Investigation into Cancer and Nutrition (EPIC) and the UK Biobank. The performance of the models to predict the occurrence of colorectal cancer within 5 or 10 years after study enrolment was assessed by discrimination (C-statistic) and calibration (plots of observed vs predicted probability)...
April 3, 2018: Gut
https://www.readbyqxmd.com/read/29588806/identifying-and-correcting-epigenetics-measurements-for-systematic-sources-of-variation
#16
Flavie Perrier, Alexei Novoloaca, Srikant Ambatipudi, Laura Baglietto, Akram Ghantous, Vittorio Perduca, Myrto Barrdahl, Sophia Harlid, Ken K Ong, Alexia Cardona, Silvia Polidoro, Therese Haugdahl Nøst, Kim Overvad, Hanane Omichessan, Martijn Dollé, Christina Bamia, José Marìa Huerta, Paolo Vineis, Zdenko Herceg, Isabelle Romieu, Pietro Ferrari
Background: Methylation measures quantified by microarray techniques can be affected by systematic variation due to the technical processing of samples, which may compromise the accuracy of the measurement process and contribute to bias the estimate of the association under investigation. The quantification of the contribution of the systematic source of variation is challenging in datasets characterized by hundreds of thousands of features.In this study, we introduce a method previously developed for the analysis of metabolomics data to evaluate the performance of existing normalizing techniques to correct for unwanted variation...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29580706/-predictive-factors-of-seclusion-duration-in-patients-hospitalized-in-psychiatry-settings-a-prospective-multisite-study-in-the-dtrf-paris-sud
#17
J-F Costemale-Lacoste, V Cerboneschi, C Trichard, R De Beaurepaire, F Villemain, J-P Metton, C Debacq, T Ghanem, C Martelli, E Baup, E Loeb, P Hardy
INTRODUCTION: In psychiatric inpatient settings seclusion is a last resort to ensure the safety of the patient, other patients, and staff from disturbed behaviors. Despite its major interest for patients, seclusion could negatively impact treatment adherence and patient/staff relationships. Indeed, some secluded patients report a feeling of guilt during the measure and do not consider seclusion to be a healthcare intervention. To be more beneficial and to reduce the feeling by patients of being forced, seclusions should be as short and rare as possible...
March 23, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29574909/iron-status-in-relation-to-cancer-risk-and-mortality-findings-from-a-population-based-prospective-study
#18
Daniel A Quintana Pacheco, Disorn Sookthai, Mirja E Graf, Ruth Schübel, Theron Johnson, Verena Katzke, Rudolf Kaaks, Tilman Kühn
While experimental evidence suggests potential carcinogenic effects of increased iron load, there is a lack of data on iron status and cancer risk from epidemiological studies. Here, we evaluated pre-diagnostic serum concentrations of ferritin, iron, and transferrin as well as transferrin saturation (TSAT) in relation to cancer risk and mortality in a prospective study by multivariable Cox regression analyses. A case-cohort sample of the population-based EPIC-Heidelberg Study including a random subcohort (n=2738) and incident cases of breast cancer (n=627), prostate cancer (n=554), lung cancer (n=195), colorectal cancer (n=256), and cancer death (n=759) was used...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29571288/bone-markers-and-cardiovascular-risk-in-type-2-diabetes-patients
#19
Sabine R Zwakenberg, Yvonne T van der Schouw, Casper G Schalkwijk, Annemieke M W Spijkerman, Joline W J Beulens
BACKGROUND: Vascular calcifications are associated with a three- to fourfold increased risk of cardiovascular disease (CVD) and are highly prevalent in type 2 diabetes patients. Emerging evidence indicates that vascular calcification is a process of active bone formation regulated by stimulators and inhibitors of calcification. Therefore, this study aimed to evaluate whether six bone markers are associated with CVD risk in patients with type 2 diabetes. METHODS: We used data of a case-cohort study, nested in the EPIC-NL cohort, comprising 134 CVD cases and a random subcohort of 218 participants, all with type 2 diabetes at baseline...
March 23, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29563134/are-metabolic-signatures-mediating-the-relationship-between-lifestyle-factors-and-hepatocellular-carcinoma-risk-results-from-a-nested-case-control-study-in-epic
#20
Nada Assi, Duncan C Thomas, Michael Leitzman, Magdalena Stepien, Veronique Chajes, Thierry Philip, Paolo Vineis, Christina Bamia, Marie-Christine Boutron-Ruault, Torkjel M Sandanger, Amaia Molinuevo, Hendriek C Boshuizen, Anneli Sundkvist, Tilman Kühn, Ruth C Travis, Kim Overvad, Elio Riboli, Marc J Gunter, Augustin Scalbert, Mazda Jenab, Pietro Ferrari, Vivian Viallon
BACKGROUND: The "meeting-in-the-middle" (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within EPIC where healthy lifestyle index (HLI) variables were related to targeted serum metabolites. METHODS: Lifestyle and targeted metabolomic data were available from 147 incident HCC cases and 147 matched controls...
March 21, 2018: Cancer Epidemiology, Biomarkers & Prevention
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