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https://www.readbyqxmd.com/read/28431419/creation-and-validation-of-an-automated-algorithm-to-determine-postoperative-ventilator-requirements-after-cardiac-surgery
#1
Eilon Gabel, Ira S Hofer, Nancy Satou, Tristan Grogan, Richard Shemin, Aman Mahajan, Maxime Cannesson
BACKGROUND: In medical practice today, clinical data registries have become a powerful tool for measuring and driving quality improvement, especially among multicenter projects. Registries face the known problem of trying to create dependable and clear metrics from electronic medical records data, which are typically scattered and often based on unreliable data sources. The Society for Thoracic Surgery (STS) is one such example, and it supports manually collected data by trained clinical staff in an effort to obtain the highest-fidelity data possible...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28423156/creation-of-an-internal-teledermatology-store-and-forward-system-in-an-existing-electronic-health-record-a-pilot-study-in-a-safety-net-public-health-and-hospital-system
#2
Zachary A Carter, Shauna Goldman, Kristen Anderson, Xiaxiao Li, Linda S Hynan, Benjamin F Chong, Arturo R Dominguez
Importance: External store-and-forward (SAF) teledermatology systems operate separately from the primary health record and have many limitations, including care fragmentation, inadequate communication among clinicians, and privacy and security concerns, among others. Development of internal SAF workflows within existing electronic health records (EHRs) should be the standard for large health care organizations for delivering high-quality dermatologic care, improving access, and capturing other telemedicine benchmark data...
April 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28419475/fruit-and-vegetable-intake-and-prostate-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#3
Aurora Perez-Cornago, Ruth C Travis, Paul N Appleby, Konstantinos K Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Verena Katzke, Tilman Kühn, Antonia Trichopoulou, Eleni Peppa, Maria Kritikou, Sabina Sieri, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H Bas Bueno-de-Mesquita, Antonio Agudo, Nerea Larrañaga, Elena Molina-Portillo, Eva Ardanaz, Maria-Dolores Chirlaque, Cristina Lasheras, Pär Stattin, Maria Wennberg, Isabel Drake, Johan Malm, Julie A Schmidt, Kay-Tee Khaw, Marc Gunter, Heinz Freisling, Inge Huybrechts, Dagfinn Aune, Amanda J Cross, Elio Riboli, Timothy J Key
Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline...
April 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28417243/criterion-related-validity-of-self-reported-stair-climbing-in-older-adults
#4
Sara Higueras-Fresnillo, Irene Esteban-Cornejo, Pablo Gasque, Oscar L Veiga, David Martinez-Gomez
INTRODUCTION: Stair climbing is an activity of daily living that might contribute to increase levels of physical activity (PA). To date, there is no study examining the validity of climbing stairs assessed by self-report. The aim of this study was, therefore, to examine the validity of estimated stair climbing from one question included in a common questionnaire compared to a pattern-recognition activity monitor in older adults. METHODS: A total of 138 older adults (94 women), aged 65-86 years (70...
April 17, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28414247/preoperative-sexual-status-of-japanese-localized-prostate-cancer-patients-comparison-of-sexual-activity-and-epic-scores
#5
Hisanori Taniguchi, Hidefumi Kinoshita, Yuya Koito, Masaaki Yanishi, Makoto Taguchi, Takao Mishima, Kenji Yoshida, Yoshihiro Komai, Kaneki Yasuda, Masato Watanabe, Motohiko Sugi, Tadashi Matsuda
OBJECTIVE: This study aimed to evaluate the relationship between sexual activity and sexual function using questionnaires distributed to middle-aged Japanese patients with localized prostate cancer. METHODS: A total of 145 patients who underwent radical prostatectomy were enrolled in the survey reported on herein. Sexual activity and sexual function were investigated via the Expanded Prostate Cancer Index Composite (EPIC) and an original self-reported questionnaire...
April 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28412047/patient-reported-quality-of-life-after-proton-beam-therapy-for-prostate-cancer-the-effect-of%C3%A2-prostate-size
#6
Anuj Goenka, Neil B Newman, Hiral Fontanilla, Oren Cahlon, Brian Chon, Henry Tsai, Eugen Hug, Carl Brown, Carlos Vargas, Rahul R Parikh
BACKGROUND: In the present study, we assessed the effect of prostate gland size on patient-assessed genitourinary and gastrointestinal (GI) quality of life (QOL) after definitive treatment of prostate adenocarcinoma with proton beam therapy. PATIENTS AND METHODS: As a part of a prospective outcome tracking protocol, 81 patients treated at a single center between with proton beam therapy completed the Expanded Prostate Cancer Index Composite (EPIC) questionnaire before treatment and at the follow-up examinations...
March 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28409495/antiplatelet-and-anti-proliferative-action-of-disintegrin-from-echis-multisquamatis-snake-venom
#7
Volodymyr Chernyshenko, Natalia Petruk, Darya Korolova, Ludmila Kasatkina, Olha Gornytska, Tetyana Platonova, Tamara Chernyshenko, Andriy Rebriev, Olena Dzhus, Liudmyla Garmanchuk, Eduard Lugovskoy
AIM: To purify the platelet aggregation inhibitor from Echis multisquamatis snake venom (PAIEM) and characterize its effect on platelet aggregation and HeLa cell proliferation. METHODS: Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) were used for PAIEM identification. Platelet aggregation in the presence of PAIEM was studied on aggregometer Solar-AP2110. The changes of shape and granularity of platelets in the presence of PAIEM were studied on flow cytometer COULTER EPICS XL, and degranulation of platelets was estimated using spectrofluorimetry...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28409278/moderate-alcohol-consumption-is-associated-with-lower-chronic-disease-burden-expressed-in-disability-adjusted-life-years-a-prospective-cohort-study
#8
Joline W J Beulens, Heidi P Fransen, Ellen A Struijk, Jolanda M A Boer, G Ardine de Wit, N Charlotte Onland-Moret, Jeljer Hoekstra, H Bas Bueno-de-Mesquita, Petra H M Peeters, Anne M May
The relation of alcohol consumption with disease burden remains debated partly due to opposite associations with cardiovascular disease (CVD) and cancer. The relation of alcohol consumption with disease burden expressed in disability-adjusted life years (DALYs) summarizes opposing associations of alcohol consumption on chronic diseases. This study aimed to investigate the association of alcohol consumption with chronic disease burden expressed in DALYs based on individual-participant data. The study was a prospective study among 33,066 men and women from the EPIC-NL cohort...
April 13, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28403081/evaluation-of-extrapancreatic-inflammation-on-abdominal-computed-tomography-as-an-early-predictor-of-organ-failure-in-acute-pancreatitis-as-defined-by-the-revised-atlanta-classification
#9
Chenyang Chen, Zixing Huang, Hang Li, Bin Song, Fang Yuan
The aim of the study was to determine whether extrapancreatic inflammation on computed tomography (EPIC) is helpful in predicting organ failure in the early phase of acute pancreatitis (AP) as defined by the 2012 revised Atlanta classification.Patients (n = 208) who underwent abdominal computed tomography (CT) within 24 hours after AP onset and admission were retrospectively identified. Each patient's EPIC score, Balthazar score, bedside index of severity in acute pancreatitis (BISAP), and systemic inflammatory response syndrome (SIRS) score were obtained...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28397507/-stereotactic-body-radiotherapy-of-prostate-cancer-effectiveness-and-toxicity
#10
E Skácelíková, D Feltl, J Cvek, T Jelenová, L Knybel, H Tomášková
BACKGROUND: Prostate cancer is the most prevalent cancer in males and its incidence is steadily increasing. Most cases of prostate cancer are diagnosed during the early asymptomatic period, in which case the prognosis is very good. Therapies differ widely in their efficacies and toxicities, and this is an important consideration when it comes to deciding which treatment is optimal for a particular patient. One treatment method for early stage prostate cancer is stereotactic body radiotherapy (SBRT)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28392843/validation-of-the-methylationepic-beadchip-for-fresh-frozen-and-formalin-fixed-paraffin-embedded-tumours
#11
Teresia Kling, Anna Wenger, Stephan Beck, Helena Carén
DNA methylation is the most studied epigenetic modification due to its role in regulating gene expression, and its involvement in the pathogenesis of cancer and several diseases upon aberrations in methylation. The method of choice to evaluate genome-wide methylation has been the Illumina HumanMethylation450 BeadChip (450K), but it was recently replaced with the MethylationEPIC BeadChip (EPIC). We therefore sought to validate the EPIC array in comparison to the 450K array for both fresh-frozen (FF) and formalin-fixed paraffin-embedded (FFPE) tumours...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28390396/validity-of-type-2-diabetes-diagnosis-in-a-population-based-electronic-health-record-database
#12
Conchi Moreno-Iribas, Carmen Sayon-Orea, Josu Delfrade, Eva Ardanaz, Javier Gorricho, Rosana Burgui, Marian Nuin, Marcela Guevara
BACKGROUND: The increasing burden of type 2 diabetes mellitus makes the continuous surveillance of its prevalence and incidence advisable. Electronic health records (EHRs) have great potential for research and surveillance purposes; however the quality of their data must first be evaluated for fitness for use. The aim of this study was to assess the validity of type 2 diabetes diagnosis in a primary care EHR database covering more than half a million inhabitants, 97% of the population in Navarra, Spain...
April 8, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28387787/metabolic-mediators-of-the-association-between-adult-weight-gain-and-colorectal-cancer-data-from-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort
#13
Krasimira Aleksandrova, Sabrina Schlesinger, Veronika Fedirko, Mazda Jenab, Bas Bueno-de-Mesquita, Heinz Freisling, Isabelle Romieu, Tobias Pischon, Rudolf Kaaks, Marc J Gunter, Christina C Dahm, Kim Overvad, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Antonia Trichopoulou, Christina Bamia, Pagona Lagiou, Claudia Agnoli, Amalia Mattiello, Kathryn Bradbury, Kay-Tee Khaw, Elio Riboli, Heiner Boeing
Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
April 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28379660/quality-of-life-after-post-prostatectomy-intensity-modulated-radiation-therapy-to-the-prostate-bed-with-or-without-the-use-of-gold-fiducial-markers-for-image-guidance-or-higher-total-radiotherapy-doses
#14
Yazan A Abuodeh, Arash O Naghavi, Tzu-Hua Juan, Zhenjun Ma, Richard B Wilder
PURPOSE: To evaluate quality of life (QoL) after post-prostatectomy intensity modulated radiation therapy (IMRT) in the "adjuvant" setting starting within 4 months of radical prostatectomy for adverse features; and "salvage" setting for a PSA≥0.2ng/mL. MATERIALS AND METHODS: Retrospective review of 130 patients who underwent IMRT to the prostate bed±gold fiducial marker placement for image guidance to 64.8-72.0Gy (median, 70.2Gy) between 2004 and 2013. Higher doses were defined as 70...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28377581/no-association-of-alcohol-use-and-the-risk-of-ulcerative-colitis-or-crohn-s-disease-data-from-a-european-prospective-cohort-study-epic
#15
M M Bergmann, V Hernandez, W Bernigau, H Boeing, S S M Chan, R Luben, K-T Khaw, F van Schaik, B Oldenburg, B Bueno-de-Mesquita, K Overvad, D Palli, G Masala, F Carbonnel, M-C Boutron-Ruault, A Olsen, A Tjonneland, R Kaaks, V Katzke, E Riboli, A R Hart
No abstract text is available yet for this article.
April 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28375948/higher-meat-intake-is-positively-associated-with-higher-risk-of-developing-pancreatic-cancer-in-an-age-dependent-manner-and-are-modified-by-plasma-antioxidants-a-prospective-cohort-study-epic-norfolk-using-data-from-food-diaries
#16
Alec J Beaney, Paul J R Banim, Robert Luben, Marleen A H Lentjes, Kay-Tee Khaw, Andrew R Hart
OBJECTIVE: Carcinogens in meat may be involved in pancreatic carcinogenesis. Meat intake was investigated using 7-day food diaries and according to factors potentially influencing carcinogenesis: age, cooking method, and antioxidants. METHODS: Twenty-three thousand one hundred thirty-three participants in the European Prospective Investigation of Cancer-Norfolk cohort study completed 7-day food diaries and were followed up. Meat intakes were compared with controls and hazard ratios (HRs) calculated...
May 2017: Pancreas
https://www.readbyqxmd.com/read/28375714/vasectomy-and-prostate-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#17
Karl Smith, Byrne, Jose Maria Castaño, Maria Dolores Chirlaque, Hans Lilja, Antonio Agudo, Eva Ardanaz, Miguel Rodríguez-Barranco, Heiner Boeing, Rudolf Kaaks, Kay-Tee Khaw, Nerea Larrañaga, Carmen Navarro, Anja Olsen, Kim Overvad, Aurora Perez-Cornago, Sabine Rohrmann, Maria José Sánchez, Anne Tjønneland, Konstantinos K Tsilidis, Mattias Johansson, Elio Riboli, Timothy J Key, Ruth C Travis
Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84,753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death...
April 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28355978/limb-symmetry-indexes-can-overestimate-knee-function-after-anterior-cruciate-ligament-injury
#18
Elizabeth Wellsandt, Mathew J Failla, Lynn Snyder-Mackler
Study Design Prospective cohort. Background The high risk of second anterior cruciate ligament (ACL) injuries after return-to-sport highlights the importance of return-to-sport decision-making. Objective return-to-sport criteria frequently use limb symmetry indexes (LSI's) to quantify quadriceps strength and hop scores. Whether using the uninvolved limb in LSI's is optimal is unknown. Objectives To evaluate the uninvolved limb as a reference standard for LSI's utilized in return-to-sport testing and its relationship with second ACL injury rates...
March 29, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28355688/-a-randomized-study-of-intensity-modulated-radiation-therapy-versus-three-dimensional-conformal-radiation-therapy-for-pelvic-radiation-in-patients-of-post-operative-treatment-with-gynecologic-malignant-tumor
#19
J Ni, Z M Yin, S H Yuan, N F Liu, L Li, X X Xu, H M Lou
Objective: To study the difference between intensity-modulated radiation therapy (IMRT) and three dimensional conformal radiation therapy (3D-CRT) for pelvic radiation of post-operative treatment with gynecologic malignant tumor. Methods: A prospective investigation study was conducted on 183 patients of post-operative patients with whole pelvic radiation therapy of cervical cancer or endometrial cancer in Zhejiang Cancer Hospital [IMRT group (n=85) and 3D-CRT group (n=98)] from Oct. 2015 to Oct. 2016. The two groups received same dose (45 Gy in 25 fractions)...
March 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28341800/variability-in-very-preterm-stillbirth-and-in-hospital-mortality-across-europe
#20
Elizabeth S Draper, Bradley N Manktelow, Marina Cuttini, Rolf F Maier, Alan C Fenton, Patrick Van Reempts, Anna-Karin Bonamy, Jan Mazela, Klaus Bᴓrch, Corinne Koopman-Esseboom, Heili Varendi, Henrique Barros, Jennifer J Zeitlin
BACKGROUND AND OBJECTIVE: Stillbirth and in-hospital mortality rates associated with very preterm births (VPT) vary widely across Europe. International comparisons are complicated by a lack of standardized data collection and differences in definitions, registration, and reporting. This study aims to determine what proportion of the variation in stillbirth and in-hospital VPT mortality rates persists after adjusting for population demographics, case-mix, and timing of death. METHODS: Standardized data collection for a geographically defined prospective cohort of VPTs (22(+0)-31(+6) weeks gestation) across 16 regions in Europe...
March 24, 2017: Pediatrics
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