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https://www.readbyqxmd.com/read/28654336/focal-therapy-for-prostate-cancer-with-in-bore-mr-guided-focused-ultrasound-two-year-follow-up-of-a-phase-i-trial-complications-and-functional-outcomes
#1
Kae Jack Tay, Christopher W S Cheng, Weber K O Lau, James Khoo, Choon Hua Thng, Jin Wei Kwek
Purpose To report the safety profile and 2-year functional outcomes of in-bore magnetic resonance (MR)-guided focused ultrasound on single cancer foci in men with prostate cancer. Materials and Methods Ethics approval was obtained from the centralized institutional review board for this prospective single-arm study, and patients provided informed consent. Patients with untreated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index tumor ≤10 mm(3)) underwent MR-guided focused ultrasound between July 2011 and February 2013...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28647811/is-it-possible-to-detect-peth-16-0-18-1-and-peth-18-1-18-1-in-red-blood-cells-after-20%C3%A2-years-of-storage-in-liquid-nitrogen
#2
Robert Boll, Theron Johnson, Rudolf Kaaks, Tilman Kühn, Gisela Skopp
INTRODUCTION: Phosphatidylethanol (PEth), as measured in freshly drawn blood samples, could be a promising new biomarker for habitual alcohol consumption, but it is still unknown whether PEth can also be determined from blood samples having been stored frozen for a longer period. MATERIALS AND METHODS: PEth 16:0/18:1 and PEth 18:1/18:1 were determined by LC-MS/MS from red blood cells (RBC) derived from blood samples of (I) 20 healthy volunteers (after 1 month of storage at -80 °C) and (II) 232 participants of the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg study (after 20 years of storage at -196 °C)...
June 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28643029/impact-of-preventable-risk-factors-on-stroke-in-the-epicor-study-does-gender-matter
#3
Slavica Trajkova, Angelo d'Errico, Fulvio Ricceri, Francesca Fasanelli, Valeria Pala, Claudia Agnoli, Rosario Tumino, Graziella Frasca, Giovanna Masala, Calogero Saieva, Paolo Chiodini, Amalia Mattiello, Carlotta Sacerdote, Salvatore Panico
OBJECTIVES: The effect of modifiable stroke risk factors in terms of prevented cases remains unclear due to sex-specific disease rate and risk factors prevalence. Our aim was to estimate their impact on stroke by gender through population-attributable fraction (PAF), preventive fraction (PF) and their combination in EPIC-Italian cohort. METHODS: 43,976 participants, age 34-75, and free of cardiovascular disease at baseline (1993-1998) were followed up for almost 11 years...
June 22, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28637522/evaluation-of-urinary-resveratrol-as-a-biomarker-of-dietary-resveratrol-intake-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#4
Raul Zamora-Ros, Joseph A Rothwell, David Achaintre, Pietro Ferrari, Marie-Christine Boutron-Ruault, Francesca R Mancini, Aurelie Affret, Tilman Kühn, Verena Katzke, Heiner Boeing, Sven Küppel, Antonia Trichopoulou, Pagona Lagiou, Carlo La Vecchia, Domenico Palli, Paolo Contiero, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Hwayoung Noh, Heinz Freisling, Isabelle Romieu, Augustin Scalbert
In vitro studies have shown several beneficial properties of resveratrol. Epidemiological evidence is still scarce, probably because of the difficulty in estimating resveratrol exposure accurately. The current study aimed to assess the relationships between acute and habitual dietary resveratrol and wine intake and urinary resveratrol excretion in a European population. A stratified random subsample of 475 men and women from four countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study, who had provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day, were included...
June 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28610958/sulfate-nitrate-and-blood-pressure-an-epic-interaction-between-sulfur-and-nitrogen
#5
Gunter G Kuhnle, Robert Luben, Kay-Tee Khaw, Martin Feelisch
Nitrate (NO3(-))-rich foods such as green leafy vegetables are not only part of a healthy diet, but increasingly marketed for primary prevention of cardiovascular disease (CVD) and used as ergogenic aids by competitive athletes. While there is abundant evidence for mild hypotensive effects of nitrate on acute application there is limited data on chronic intake in humans, and results from animal studies suggest no long-term benefit. This is important as nitrate can also promote the formation of nitrosamines...
June 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28594416/a-comparison-of-cox-and-logistic-regression-for-use-in-genome-wide-association-studies-of-cohort-and-case-cohort-design
#6
James R Staley, Edmund Jones, Stephen Kaptoge, Adam S Butterworth, Michael J Sweeting, Angela M Wood, Joanna M M Howson
Logistic regression is often used instead of Cox regression to analyse genome-wide association studies (GWAS) of single-nucleotide polymorphisms (SNPs) and disease outcomes with cohort and case-cohort designs, as it is less computationally expensive. Although Cox and logistic regression models have been compared previously in cohort studies, this work does not completely cover the GWAS setting nor extend to the case-cohort study design. Here, we evaluated Cox and logistic regression applied to cohort and case-cohort genetic association studies using simulated data and genetic data from the EPIC-CVD study...
June 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28592605/interaction-between-genes-and-macronutrient-intake-on-the-risk-of-developing-type-2-diabetes-systematic-review-and-findings-from-european-prospective-investigation-into-cancer-epic-interact
#7
Sherly X Li, Fumiaki Imamura, Zheng Ye, Matthias B Schulze, Jusheng Zheng, Eva Ardanaz, Larraitz Arriola, Heiner Boeing, Courtney Dow, Guy Fagherazzi, Paul W Franks, Antonio Agudo, Sara Grioni, Rudolf Kaaks, Verena A Katzke, Timothy J Key, Kay Tee Khaw, Francesca R Mancini, Carmen Navarro, Peter M Nilsson, N Charlotte Onland-Moret, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, María-José Sánchez, Nadia Slimani, Ivonne Sluijs, Annemieke Mw Spijkerman, Anne Tjonneland, Rosario Tumino, Stephen J Sharp, Elio Riboli, Claudia Langenberg, Robert A Scott, Nita G Forouhi, Nicholas J Wareham
Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date.Objective: We aimed to identify existing evidence for gene-macronutrient interactions and T2D and to examine the reported interactions in a large-scale study.Design: We systematically reviewed studies reporting gene-macronutrient interactions and T2D. We searched the MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials Registry Platform electronic databases to identify studies published up to October 2015...
June 7, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28592517/consumption-of-fish-is-not-associated-with-risk-of-differentiated-thyroid-carcinoma-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#8
Raul Zamora-Ros, Jazmín Castañeda, Sabina Rinaldi, Valerie Cayssials, Nadia Slimani, Elisabete Weiderpass, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Kim Overvad, Anne K Eriksen, Anne Tjønneland, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Carlo La Vecchia, Anastasia Kotanidou, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Veronica Sciannameo, Eiliv Lund, Susana Merino, Elena Salamanca-Fernández, Pilar Amiano, José María Huerta, Aurelio Barricarte, Ulrika Ericson, Martin Almquist, Joakim Hennings, Maria Sandström, H Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Tee Khaw, Nicholas J Wareham, Julie A Schmidt, Amanda J Cross, Elio Riboli, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Silvia Franceschi
Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Methods: EPIC is a cohort of >500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries...
June 7, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28587685/carotenoid-dietary-intakes-and-plasma-concentrations-are-associated-with-heel-bone-ultrasound-attenuation-and-osteoporotic-fracture-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-norfolk-cohort
#9
Richard P G Hayhoe, Marleen A H Lentjes, Angela A Mulligan, Robert N Luben, Kay-Tee Khaw, Ailsa A Welch
Carotenoids are found in abundance in fruit and vegetables, and may be involved in the positive association of these foods with bone health. This study aimed to explore the associations of dietary carotenoid intakes and plasma concentrations with bone density status and osteoporotic fracture risk in a European population. Cross-sectional analyses (n 14 803) of bone density status, using calcaneal broadband ultrasound attenuation (BUA) and longitudinal analyses (n 25 439) of fracture cases were conducted on data from the prospective European Prospective Investigation into Cancer and Nutrition-Norfolk cohort of middle-aged and older men and women...
June 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28575311/pre-diagnostic-copper-and-zinc-biomarkers-and-colorectal-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-cohort
#10
Magdalena Stepien, Mazda Jenab, Heinz Freisling, Niels-Peter Becker, Magdalena Czuban, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Isabelle Savoye, Verena Katzke, Tilman Kühn, Heiner Boeing, Khalid Iqbal, Antonia Trichopoulou, Christina Bamia, Philippos Orfanos, Domenico Palli, Sabina Sieri, Rosario Tumino, Alessio Naccarati, Salvatore Panico, H B As Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, Susana Merino, Paula Jakszyn, Maria-Jose Sanchez, Miren Dorronsoro, José María Huerta, Aurelio Barricarte, Stina Boden, Behany van Guelpen, Nick Wareham, Kay-Tee Khaw, Kathryn E Bradbury, Amanda J Cross, Lutz Schomburg, David J Hughes
Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development...
June 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28575193/the-cost-structure-of-routine-infant-immunization-services-a-systematic-analysis-of-six-countries
#11
Fangli Geng, Christian Suharlim, Logan Brenzel, Stephen C Resch, Nicolas A Menzies
Little information exists on the cost structure of routine infant immunization services in low- and middle-income settings. Using a unique dataset of routine infant immunization costs from six countries, we estimated how costs were distributed across budget categories and programmatic activities, and investigated how the cost structure of immunization sites varied by country and site characteristics. The EPIC study collected data on routine infant immunization costs from 319 sites in Benin, Ghana, Honduras, Moldova, Uganda, Zambia, using a standardized approach...
May 31, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28571971/biological-reproducibility-of-circulating-p-selectin-thrombopoietin-gpiib-iiia-and-thrombomodulin-over-one-year
#12
Mirja E Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn
BACKGROUND: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be used as reliable biomarkers of platelet activation in epidemiological studies. METHODS: We measured circulating P-Selectin, TM, TPO and GPIIb/IIIa by immunoassays in two blood samples of 78 participants of the EPIC Heidelberg study (47-80years, 50% female) that were collected one year apart...
May 29, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28562613/weather-day-length-and-physical-activity-in-older-adults-cross-sectional-results-from-the-european-prospective-investigation-into-cancer-and-nutrition-epic-norfolk-cohort
#13
Yu-Tzu Wu, Robert Luben, Nicholas Wareham, Simon Griffin, Andy P Jones
BACKGROUND: A wide range of environmental factors have been related to active ageing, but few studies have explored the impact of weather and day length on physical activity in older adults. We investigate the cross-sectional association between weather conditions, day length and activity in older adults using a population-based cohort in England, the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk study. METHODS: Physical activity was measured objectively over 7 days using an accelerometer and this was used to calculate daily total physical activity (counts per minute), daily minutes of sedentary behaviour and light, moderate and vigorous physical activity (LMVPA)...
2017: PloS One
https://www.readbyqxmd.com/read/28550647/genetic-variation-in-the-adipoq-gene-adiponectin-concentrations-and-risk-of-colorectal-cancer-a-mendelian-randomization-analysis-using-data-from-three-large-cohort-studies
#14
Katharina Nimptsch, Mingyang Song, Krasimira Aleksandrova, Michail Katsoulis, Heinz Freisling, Mazda Jenab, Marc J Gunter, Konstantinos K Tsilidis, Elisabete Weiderpass, H Bas Bueno-De-Mesquita, Dawn Q Chong, Majken K Jensen, Chunsen Wu, Kim Overvad, Tilman Kühn, Myrto Barrdahl, Olle Melander, Karin Jirström, Petra H Peeters, Sabina Sieri, Salvatore Panico, Amanda J Cross, Elio Riboli, Bethany Van Guelpen, Robin Myte, José María Huerta, Miguel Rodriguez-Barranco, José Ramón Quirós, Miren Dorronsoro, Anne Tjønneland, Anja Olsen, Ruth Travis, Marie-Christine Boutron-Ruault, Franck Carbonnel, Gianluca Severi, Catalina Bonet, Domenico Palli, Jürgen Janke, Young-Ae Lee, Heiner Boeing, Edward L Giovannucci, Shuji Ogino, Charles S Fuchs, Eric Rimm, Kana Wu, Andrew T Chan, Tobias Pischon
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28544925/less-workup-longer-treatment-but-no-clinical-benefit-observed-in-women-with-diabetes-and-acute-cystitis
#15
Larissa Grigoryan, Roger Zoorob, Haijun Wang, Matthew Horsfield, Kalpana Gupta, Barbara W Trautner
AIMS: There is a lack of evidence on the optimal approach for treating acute cystitis in women with diabetes. We performed an outpatient database study to compare management of women with and without diabetes and to assess the effect of treatment duration on early and late recurrence. METHODS: We used the EPIC Clarity database (electronic medical record system) to identify all female patients aged ≥18years with acute cystitis in two family medicine clinics and a urology department...
July 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28543377/hepcidin-levels-and-gastric-cancer-risk-in-the-epic-eurgast-study
#16
Paula Jakszyn, Ana Fonseca-Nunes, Leila Lujan-Barroso, Núria Aranda, Mónica Tous, Victoria Arija, Amanda Cross, H B As Bueno-de-Mesquita, Elisabete Weiderpass, Tilman Kühn, Rudolf Kaaks, Klas Sjöberg, Bodil Ohlsson, Rosario Tumino, Domenico Palli, Fulvio Ricceri, Francesca Fasanelli, Vittorio Krogh, Amalia Mattiello, Mazda Jenab, Marc Gunter, Aurora Perez-Cornago, Kay-Tee Khaw, Anne Tjønneland, Anja Olsen, Kim Overvad, Antonia Trichopoulou, Eleni Peppa, Effie Vasilopoulou, Heiner Boeing, Emilio Sánchez-Cantalejo, José María Huerta, Miren Dorronsoro, Aurelio Barricarte, José Maria Quirós, Petra H Peeters, Antonio Agudo
Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up...
May 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28542740/plasma-micrornas-as-biomarkers-of-pancreatic-cancer-risk-in-a-prospective-cohort-study
#17
Eric J Duell, Leila Lujan-Barroso, Núria Sala, Samantha Deitz McElyea, Kim Overvad, Anne Tjonneland, Anja Olsen, Elisabete Weiderpass, Lill-Tove Busund, Line Moi, David Muller, Paolo Vineis, Dagfinn Aune, Giuseppe Matullo, Alessio Naccarati, Salvatore Panico, Giovanna Tagliabue, Rosario Tumino, Domenico Palli, Rudolf Kaaks, Verena A Katzke, Heiner Boeing, H B As Bueno-de-Mesquita, Petra H Peeters, Antonia Trichopoulou, Pagona Lagiou, Anastasia Kotanidou, Ruth C Travis, Nick Wareham, Kay-Tee Khaw, Jose Ramon Quiros, Miguel Rodríguez-Barranco, Miren Dorronsoro, María-Dolores Chirlaque, Eva Ardanaz, Gianluca Severi, Marie-Christine Boutron-Ruault, Vinciane Rebours, Paul Brennan, Marc Gunter, Ghislaine Scelo, Greg Cote, Stuart Sherman, Murray Korc
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, -155 and -212) based on previous evidence from our group was evaluated in 225 microscopically confirmed PDAC cases and 225 controls matched on center, sex, fasting status and age/date/time of blood collection...
May 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28535209/aromatic-dna-adducts-and-breast-cancer-risk-a-case-cohort-study-within-the-epic-spain
#18
Antonio Agudo, Marco Peluso, Armelle Munnia, Leila Luján-Barroso, Aurelio Barricarte, Pilar Amiano, Carmen Navarro, María-José Sánchez, J Ramón Quirós, Eva Ardanaz, Nerea Larrañaga, María-José Tormo, María-Dolores Chirlaque, Miguel Rodríguez-Barranco, Emilio Sánchez-Cantalejo, Filippo Cellai, Catalina Bonet, Núria Sala, Carlos A González
Epidemiologic evidence linking environmental exposure to polycyclic aromatic hydrocarbons (PAH) with breast cancer is limited. Measurement of DNA adducts formed by aromatic compounds, including PAH, has been carried in breast tissue samples and white blood cells from women with breast cancer and different kinds of controls. However, these studies provide inconsistent results and bias cannot be ruled out. During the 7-year follow-up period, 305 women were diagnosed with first primary breast cancer in the EPIC-Spain cohort, and were compared with a sample of 149 women without breast cancer at recruitment, using a case-cohort approach...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28533102/real-time-electronic-dashboard-technology-and-its-use-to-improve-pediatric-radiology-workflow
#19
REVIEW
Randheer Shailam, Ariel Botwin, Markus Stout, Michael S Gee
The purpose of our study was to create a real-time electronic dashboard in the pediatric radiology reading room providing a visual display of updated information regarding scheduled and in-progress radiology examinations that could help radiologists to improve clinical workflow and efficiency. To accomplish this, a script was set up to automatically send real-time HL7 messages from the radiology information system (Epic Systems, Verona, WI) to an Iguana Interface engine, with relevant data regarding examinations stored in an SQL Server database for visual display on the dashboard...
March 19, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28530674/fifteen-new-risk-loci-for-coronary-artery-disease-highlight-arterial-wall-specific-mechanisms
#20
Joanna M M Howson, Wei Zhao, Daniel R Barnes, Weang-Kee Ho, Robin Young, Dirk S Paul, Lindsay L Waite, Daniel F Freitag, Eric B Fauman, Elias L Salfati, Benjamin B Sun, John D Eicher, Andrew D Johnson, Wayne H H Sheu, Sune F Nielsen, Wei-Yu Lin, Praveen Surendran, Anders Malarstig, Jemma B Wilk, Anne Tybjærg-Hansen, Katrine L Rasmussen, Pia R Kamstrup, Panos Deloukas, Jeanette Erdmann, Sekar Kathiresan, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Ron Do, Daniel J Rader, Julie A Johnson, Stanley L Hazen, Arshed A Quyyumi, John A Spertus, Carl J Pepine, Nora Franceschini, Anne Justice, Alex P Reiner, Steven Buyske, Lucia A Hindorff, Cara L Carty, Kari E North, Charles Kooperberg, Eric Boerwinkle, Kristin Young, Mariaelisa Graff, Ulrike Peters, Devin Absher, Chao A Hsiung, Wen-Jane Lee, Kent D Taylor, Ying-Hsiang Chen, I-Te Lee, Xiuqing Guo, Ren-Hua Chung, Yi-Jen Hung, Jerome I Rotter, Jyh-Ming J Juang, Thomas Quertermous, Tzung-Dau Wang, Asif Rasheed, Philippe Frossard, Dewan S Alam, Abdulla Al Shafi Majumder, Emanuele Di Angelantonio, Rajiv Chowdhury, Yii-Der Ida Chen, Børge G Nordestgaard, Themistocles L Assimes, John Danesh, Adam S Butterworth, Danish Saleheen
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls...
May 22, 2017: Nature Genetics
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