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https://www.readbyqxmd.com/read/28093464/socioeconomic-status-smoke-exposure-and-health-outcomes-in-young-children-with-cystic-fibrosis
#1
Thida Ong, Michael Schechter, Jing Yang, Limin Peng, Julia Emerson, Ronald L Gibson, Wayne Morgan, Margaret Rosenfeld
BACKGROUND: Lower socioeconomic status (SES) and environmental tobacco smoke (ETS) exposure are both associated with poorer disease outcomes in cystic fibrosis (CF), and children with low SES are disproportionately exposed to ETS. We analyzed a large cohort of young children with CF to distinguish the impact of SES and ETS on clinical outcomes. METHODS: The Early Pseudomonas Infection Control Observational study enrolled Pseudomonas-negative young children with CF <13 years of age...
January 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28074892/are-sleep-duration-midpoint-of-sleep-and-sleep-quality-associated-with-dietary-intake-among-bavarian-adults
#2
C Kleiser, N Wawro, M Stelmach-Mardas, H Boeing, K Gedrich, H Himmerich, J Linseisen
BACKGROUND/OBJECTIVES: Only few epidemiologic studies examined sleep characteristics in relation to dietary behaviour. Our aim was to analyse associations of sleep duration, midpoint of sleep and sleep quality with dietary intake among the Bavarian population. SUBJECTS/METHODS: Within the cross-sectional Bavarian Food Consumption Survey II, 1050 subjects aged 13-81 years were recruited. Dietary intake was assessed with three 24-h dietary recalls by telephone (EPIC-Soft)...
January 11, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28073425/hypertension-in-germany
#3
Hannelore Neuhauser, Claudia Diederichs, Heiner Boeing, Stephan B Felix, Claus Jünger, Roberto Lorbeer, Christine Meisinger, Annette Peters, Henry Völzke, Cornelia Weikert, Philipp Wild, Marcus Dörr
BACKGROUND: Hypertension is a key risk factor. However, population data based on blood pressure measurements in Germany are scarce. METHODS: Standardized blood pressure (BP) measurements and medication data from seven population-based studies conducted in Germany between 1994 and 2012 (66 845 participants, 25-74 years) were analyzed: the EPICPotsdam study (1994-1998, EPIC), the KORA-S4 Study (1999-2001) in Augsburg, and the Gutenberg Health Study (2007-2012, GHS) in Mainz/Mainz-Bingen provided data for descriptive comparisons...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28032715/helicobacter-pylori-infection-chronic-corpus-atrophic-gastritis-and-pancreatic-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort-a-nested-case-control-study
#4
Jiaqi Huang, Ulrika Zagai, Göran Hallmans, Olof Nyrén, Lars Engstrand, Rachael Stolzenberg-Solomon, Eric J Duell, Kim Overvad, Verena A Katzke, Rudolf Kaaks, Mazda Jenab, Jin Young Park, Raul Murillo, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kathryn E Bradbury, Elio Riboli, Dagfinn Aune, Konstantinos K Tsilidis, Gabriel Capellá, Antonio Agudo, Vittorio Krogh, Domenico Palli, Salvatore Panico, Elisabete Weiderpass, Anne Tjønneland, Anja Olsen, Begoña Martínez, Daniel Redondo-Sanchez, Maria-Dolores Chirlaque, Petra Hm Peeters, Sara Regnér, Björn Lindkvist, Alessio Naccarati, Eva Ardanaz, Nerea Larrañaga, Marie-Christine Boutron-Ruault, Vinciane Rebours, Amélie Barré, H B As Bueno-de-Mesquita, Weimin Ye
The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders...
December 29, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28024800/dietary-assessment-in-the-metacardis-study-development-and-relative-validity-of-an-online-food-frequency-questionnaire
#5
Eric O Verger, Patrice Armstrong, Trine Nielsen, Rima Chakaroun, Judith Aron-Wisnewsky, Rikke Juul Gøbel, Tatjana Schütz, Fabien Delaere, Nicolas Gausseres, Karine Clément, Bridget A Holmes
BACKGROUND: The European study MetaCardis aims to investigate the role of the gut microbiota in health and cardiometabolic diseases in France, Germany, and Denmark. To evaluate long-term diet-disease relationships, a food frequency questionnaire (FFQ) was found to be the most relevant dietary assessment method for the MetaCardis study. OBJECTIVE: The objectives of this study were to describe the development of three semiquantitative online FFQs used in the MetaCardis study-one FFQ per country-and to assess the relative validity of the French MetaCardis FFQ...
December 23, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28007685/early-prediction-of-organ-failure-under-the-revised-atlanta-classification
#6
Jian Liu, Feng Cao, Xiao Min Dong, Peng Yu Li, Hai Chao Li, Bao Ju Qi, Fei Li
BACKGROUND/AIMS: This study aimed to compare the ability of conventional laboratory markers and scoring systems to early predict organ failure (OF) and to differentiate between transient and persistent OF in patients with acute pancreatitis (AP) using the revised Atlanta classification. MATERIALS AND METHODS: We retrospectively analyzed the medical records of 214 patients with AP between January 2014 and July 2015. The predictive values of laboratory markers were analyzed...
December 23, 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28006847/dietary-flavonoid-intake-and-colorectal-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort
#7
Raul Zamora-Ros, Dinesh K Barupal, Joseph A Rothwell, Mazda Jenab, Veronika Fedirko, Isabelle Romieu, Krasimira Aleksandrova, Kim Overvad, Cecilie Kyrø, Anne Tjønneland, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Maria Kritikou, Calogero Saieva, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Francesca Fasanelli, Elisabete Weiderpass, Guri Skeie, Susana Merino, Paula Jakszyn, Maria-José Sánchez, Miren Dorronsoro, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Lena Maria Nilsson, Stina Bodén, H Bas Bueno-de-Mesquita, Petra H Peeters, Aurora Perez-Cornago, Nicholas J Wareham, Kay-Thee Khaw, Heinz Freisling, Amanda J Cross, Elio Riboli, Augustin Scalbert
Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries...
December 22, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28004270/determinants-of-folate-and-vitamin-b12-plasma-levels-in-the-french-e3n-epic-cohort
#8
Jordi de Batlle, Marco Matejcic, Veronique Chajes, Hortensia Moreno-Macias, Amina Amadou, Nadia Slimani, David G Cox, Françoise Clavel-Chapelon, Guy Fagherazzi, Isabelle Romieu
PURPOSE: Impaired B vitamin status has been identified as a risk factor for major chronic diseases. This study aims at examining the determinants of plasma folate and vitamin B12 concentrations, considering lifestyle factors and MTHFR polymorphisms. METHODS: A total of 988 women aged 40-65 years from the French E3N cohort were investigated. Intakes of folate and vitamin B12 were assessed using food frequency questionnaires, and plasma concentrations were measured by microbiological assay...
December 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/28004268/dietary-intake-and-major-food-sources-of-polyphenols-in-people-with-type-2-diabetes-the-tosca-it-study
#9
M Vitale, M Masulli, A A Rivellese, E Bonora, F Cappellini, A Nicolucci, S Squatrito, D Antenucci, A Barrea, C Bianchi, F Bianchini, L Fontana, P Fornengo, F Giorgino, A Gnasso, E Mannucci, A Mazzotti, R Nappo, A P Palena, P Pata, G Perriello, S Potenziani, R Radin, L Ricci, F Romeo, C Santini, M Scarponi, R Serra, A Timi, A A Turco, M Vedovato, D Zavaroni, S Grioni, G Riccardi, O Vaccaro
PURPOSE: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. METHODS: We studied 2573 men and women aged 50-75 years...
December 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/28001327/supraspinatus-tendon-overuse-results-in-degenerative-changes-to-tendon-insertion-region-and-adjacent-humeral-cartilage-in-a-rat-model
#10
Akia N Parks, Jennifer McFaline-Figueroa, Anne Coogan, Emma Poe-Yamagata, Robert E Guldberg, Manu O Platt, Johnna S Temenoff
The etiology of rotator cuff tendon overuse injuries is still not well understood. Furthermore, how this overuse injury impacts other components of the glenohumeral joint, including nearby articular cartilage, is also unclear. Therefore, this study sought to better understand the time course of tendon protease activity in a rat model of supraspinatus overuse, as well as determine effects of 10 weeks of overuse on humeral head articular cartilage. For these studies, multiplex gelatin zymography was used to characterize protease activity profiles in tendon and cartilage, while histological scoring/mechanical testing and micro-computed tomography (μCT) imaging were used to quantify structural damage in the supraspinatus tendon insertion and humeral articular cartilage, respectively...
December 21, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27998826/ideal-cardiovascular-health-influences-cardiovascular-disease-risk-associated-with-high-lipoprotein-a-levels-and-genotype-the-epic-norfolk-prospective-population-study
#11
Nicolas Perrot, Rutger Verbeek, Manjinder Sandhu, S Matthijs Boekholdt, G Kees Hovingh, Nicholas J Wareham, Kay-Tee Khaw, Benoit J Arsenault
BACKGROUND AND AIMS: Lipoprotein(a) (Lp[a]) is a strong genetic risk factor for cardiovascular disease (CVD). The American Heart Association has prioritised seven cardiovascular health metrics to reduce the burden of CVD: body mass index, healthy diet, physical activity, smoking status, blood pressure, diabetes and cholesterol levels (together also known as ideal cardiovascular health). Our objective was to determine if individuals with high Lp(a) levels could derive cardiovascular benefits if characterized by ideal cardiovascular health...
November 11, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27989833/identification-and-characterization-of-protein-14-3-3-in-carcinogenic-liver-fluke-opisthorchis-viverrini
#12
Alok Kafle, Pranom Puchadapirom, Sirikanya Plumworasawat, Rieofarng Dontumprai, Waraporn Chan-On, Sureemas Buates, Thewarach Laha, Banchob Sripa, Sutas Suttiprapa
Protein 14-3-3s are abundant phospho-serine/threonine binding proteins, which are highly conserved among eukaryotes. Members of this protein family mediate metabolism and signal transduction networks through binding to hundreds of other protein partners. Protein 14-3-3s have been studied in other species of parasitic helminthes, but little is known about this protein in the carcinogenic liver fluke Opisthorchis viverrini. In this study, we identified and characterized protein 14-3-3s of O. viverrini. Seven protein 14-3-3 encoded sequences were retrieved from the O...
October 27, 2016: Parasitology International
https://www.readbyqxmd.com/read/27955940/magnetic-resonance-imaging-transrectal-ultrasound-fusion-focal-cryotherapy-of-the-prostate-a-prospective-development-study
#13
Massimo Valerio, Taimur Tariq Shah, Paras Shah, Neil Mccartan, Mark Emberton, Manit Arya, Hashim Uddin Ahmed
OBJECTIVES: The use of software-based magnetic resonance-transrectal ultrasound fusion to deliver focal therapy may increase the precision of treatment. This is a prospective development study assessing the feasibility of Magnetic resonance imaging-transrectal ultrasound (MRI-TRUS) fusion focal cryotherapy. METHODS AND MATERIALS: Consecutive patients undergoing focal cryotherapy were included in an academic registry (December 2013-June 2014). MRI-TRUS fusion focal cryotherapy was offered to men with visible clinically significant prostate cancer (Galil SeedNet system)...
December 7, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27943174/the-dutch-score-based-risk-charts-seriously-underestimate-the%C3%A2-risk-of-cardiovascular-disease
#14
H T Jørstad, S M Boekholdt, N J Wareham, K T Khaw, R J G Peters
INTRODUCTION: Dutch cardiovascular disease (CVD) prevention guidelines recommend the use of modified SCORE risk charts to estimate 10-year risk of fatal and nonfatal CVD (myocardial infarction, cerebrovascular disease and congestive heart failure). This combined risk is derived from the SCORE mortality risk using multipliers. These multipliers have been shown to underestimate overall CVD risk. We aimed to compare the current Dutch risk charts with charts that estimate a broader range of clinically relevant CVD using updated multipliers...
December 9, 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27940953/genetic-invalidation-of-lp-pla2-as-a-therapeutic-target-large-scale-study-of-five-functional-lp-pla2-lowering-alleles
#15
John M Gregson, Daniel F Freitag, Praveen Surendran, Nathan O Stitziel, Rajiv Chowdhury, Stephen Burgess, Stephen Kaptoge, Pei Gao, James R Staley, Peter Willeit, Sune F Nielsen, Muriel Caslake, Stella Trompet, Linda M Polfus, Kari Kuulasmaa, Jukka Kontto, Markus Perola, Stefan Blankenberg, Giovanni Veronesi, Francesco Gianfagna, Satu Männistö, Akinori Kimura, Honghuang Lin, Dermot F Reilly, Mathias Gorski, Vladan Mijatovic, Patricia B Munroe, Georg B Ehret, Alex Thompson, Maria Uria-Nickelsen, Anders Malarstig, Abbas Dehghan, Thomas F Vogt, Taishi Sasaoka, Fumihiko Takeuchi, Norihiro Kato, Yoshiji Yamada, Frank Kee, Martina Müller-Nurasyid, Jean Ferrières, Dominique Arveiler, Philippe Amouyel, Veikko Salomaa, Eric Boerwinkle, Simon G Thompson, Ian Ford, J Wouter Jukema, Naveed Sattar, Chris J Packard, Abdulla Al Shafi Majumder, Dewan S Alam, Panos Deloukas, Heribert Schunkert, Nilesh J Samani, Sekar Kathiresan, Børge G Nordestgaard, Danish Saleheen, Joanna Mm Howson, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh
AIMS: Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. METHODS: In 72,657 patients with coronary heart disease and 110,218 controls in 23 epidemiological studies, we genotyped five functional variants: four rare loss-of-function mutations (c.109+2T > C (rs142974898), Arg82His (rs144983904), Val279Phe (rs76863441), Gln287Ter (rs140020965)) and one common modest-impact variant (Val379Ala (rs1051931)) in PLA2G7, the gene encoding Lp-PLA2...
December 11, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27935083/endometrial-cancer-risk-prediction-including-serum-based-biomarkers-results-from-the-epic-cohort
#16
Renée T Fortner, Anika Hüsing, Tilman Kühn, Meric Konar, Kim Overvad, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Gianluca Severi, Agnès Fournier, Heiner Boeing, Antonia Trichopoulou, Vasiliki Benetou, Philippos Orfanos, Giovanna Masala, Claudia Agnoli, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Petra H M Peeters, Elisabete Weiderpass, Inger T Gram, Oxana Gavrilyuk, J Ramón Quirós, José Maria Huerta, Eva Ardanaz, Nerea Larrañaga, Leila Lujan-Barroso, Emilio Sánchez-Cantalejo, Salma Tunå Butt, Signe Borgquist, Annika Idahl, Eva Lundin, Kay-Tee Khaw, Naomi E Allen, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A Merritt, Ioanna Tzoulaki, Elio Riboli, Rudolf Kaaks
Endometrial cancer risk prediction models including lifestyle, anthropometric, and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors...
December 9, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27934951/biological-marks-of-early-life-socioeconomic-experience-is-detected-in-the-adult-inflammatory-transcriptome
#17
Raphaële Castagné, Michelle Kelly-Irving, Gianluca Campanella, Florence Guida, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Jos Kleinjans, Theo de Kok, Soterios A Kyrtopoulos, Thierry Lang, Silvia Stringhini, Roel Vermeulen, Paolo Vineis, Cyrille Delpierre, Marc Chadeau-Hyam
Consistent evidence is accumulating to link lower socioeconomic position (SEP) and poorer health, and the inflammatory system stands out as a potential pathway through which socioeconomic environment is biologically embedded. Using bloodderived genome-wide transcriptional profiles from 268 Italian participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we evaluated the association between early life, young and later adulthood SEP and the expression of 845 genes involved in human inflammatory responses...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27932393/biological-characteristics-of-embryonic-epicardial-cells-in-vitro-correlate-with-embryonic-day
#18
Xiaoming Wei, Yulin Gao, Xiaodong Jing, Songbai Deng, Jianlin Du, Yajie Liu, Qiang She
The epicardial cell (EpiC) culture system plays an important role in investigating the specific mechanisms and signaling molecules that are involved in the development of EpiCs. From this early formation until adulthood, EpiCs undergo dynamic changes in the expression of embryonic genes that correlate with changes in the embryonic EpiC properties. The differences of embryonic EpiC properties may affect the related results of experiments in which EpiC culture system is used; however, these differences have not been explored...
January 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27930656/cross-sectional-associations-between-socio-demographic-factors-and-cognitive-performance-in-an-older-british-population-the-european-investigation-of-cancer-in-norfolk-epic-norfolk-study
#19
Shabina A Hayat, Robert Luben, Nichola Dalzell, Stephanie Moore, Serena Anuj, Fiona E Matthews, Nick Wareham, Carol Brayne, Kay-Tee Khaw
BACKGROUND: Cognition covers a range of abilities, such as memory, response time and language, with tests assessing either specific or generic aspects. However differences between measures may be observed within the same individuals. OBJECTIVE: To investigate the cross-sectional association of cognitive performance and socio-demographic factors using different assessment tools across a range of abilities in a British cohort study. METHODS: Participants of the European Prospective Investigation of Cancer (EPIC) in Norfolk Study, aged 48-92 years, underwent a cognitive assessment between 2006 and 2011 (piloted between 2004 and 2006) and were investigated over a different domains using a range of cognitive tests...
2016: PloS One
https://www.readbyqxmd.com/read/27923377/cross-cultural-adaptation-and-validation-of-the-french-version-of-the-expanded-prostate-cancer-index-composite-questionnaire-for-health-related-quality-of-life-in-prostate-cancer-patients
#20
Amélie Anota, Anne-Sophie Mariet, Philippe Maingon, Florence Joly, Jean-François Bosset, Anne-Valérie Guizard, Hugues Bittard, Michel Velten, Mariette Mercier
BACKGROUND: Health-related quality of life (HRQoL) has been positioned as one of the major endpoints in oncology. Thus, there is a need to validate cancer-site specific survey instruments. This study aimed to perform a transcultural adaptation of the 50-item Expanded Prostate cancer Index Composite (EPIC) questionnaire for HRQoL in prostate cancer patients and to validate the psychometric properties of the French-language version. METHODS: The EPIC questionnaire measures urinary, bowel, sexual and hormonal domains...
December 6, 2016: Health and Quality of Life Outcomes
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