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https://www.readbyqxmd.com/read/27905104/biomarkers-of-folate-and-vitamin-b12-and-breast-cancer-risk-report-from-the-epic-cohort
#1
M Matejcic, J de Batlle, C Ricci, C Biessy, F Perrier, I Huybrechts, E Weiderpass, Boutron-Mc Ruault, C Cadeau, M His, D G Cox, H Boeing, R T Fortner, R Kaaks, P Lagiou, A Trichopoulou, V Benetou, R Tumino, S Panico, S Sieri, D Palli, F Ricceri, H B Bueno-de-Mesquita, G Skeie, P Amiano, M J Sánchez, M D Chirlaque, A Barricarte, J R Quirós, G Buckland, C H van Gils, P H Peeters, T J Key, E Riboli, B Gylling, A Zeleniuch-Jacquotte, M J Gunter, I Romieu, V Chajès
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin...
December 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27892610/beside-to-bench-jak-inhibitor-ruxolitinib-inhibits-the-expression-of-cytokines-characteristic-of-cutaneous-lupus-erythematosus
#2
Anna Sophie Klaeschen, Dominik Wolf, Peter Brossart, Thomas Bieber, Joerg Wenzel
This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in-vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in-vitro effect of ruxolitinib in cultured immortalized keratinocytes and in a 3D human epidermis model (epiCS). Our results demonstrate that ruxolitinib significantly decreases the production of CLE-typical cytokines (CXCL10, CXCL9, MxA) and might be a promising drug for future clinical studies in patients with CLE and related autoimmune skin diseases...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27890487/polyphenol-intake-and-cardiovascular-risk-factors-in-a-population-with%C3%A2-type-2-diabetes-the-tosca-it-study
#3
Marilena Vitale, Olga Vaccaro, Maria Masulli, Enzo Bonora, Stefano Del Prato, Carlo B Giorda, Antonio Nicolucci, Sebastiano Squatrito, Stefania Auciello, Anna C Babini, Laura Bani, Raffaella Buzzetti, Emanuela Cannarsa, Mauro Cignarelli, Massimo Cigolini, Gennaro Clemente, Sara Cocozza, Laura Corsi, Federica D'Angelo, Elisabetta Dall'Aglio, Graziano Di Cianni, Lucia Fontana, Giovanna Gregori, Sara Grioni, Carla Giordano, Rossella Iannarelli, Ciro Iovine, Annunziata Lapolla, Davide Lauro, Luigi Laviola, Chiara Mazzucchelli, Stefano Signorini, Laura Tonutti, Roberto Trevisan, Chiara Zamboni, Gabriele Riccardi, Angela A Rivellese
BACKGROUND: The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes. AIM: To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes. METHODS: Dietary habits were investigated in 2573 males and females participants of the TOSCA.IT study. The European Prospective Investigation on Cancer and Nutrition (EPIC) questionnaire was used to assess dietary habits...
November 14, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27888338/a-comprehensively-quantitative-method-of-evaluating-the-impact-of-drought-on-crop-yield-using-daily-multi-scale-spei-and-crop-growth-process-model
#4
Qianfeng Wang, Jianjun Wu, Xiaohan Li, Hongkui Zhou, Jianhua Yang, Guangpo Geng, Xueli An, Leizhen Liu, Zhenghong Tang
The quantitative evaluation of the impact of drought on crop yield is one of the most important aspects in agricultural water resource management. To assess the impact of drought on wheat yield, the Environmental Policy Integrated Climate (EPIC) crop growth model and daily Standardized Precipitation Evapotranspiration Index (SPEI), which is based on daily meteorological data, are adopted in the Huang Huai Hai Plain. The winter wheat crop yields are estimated at 28 stations, after calibrating the cultivar coefficients based on the experimental site data, and SPEI data was taken 11 times across the growth season from 1981 to 2010...
November 25, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27872151/non-occupational-physical-activity-levels-of-shift-workers-compared-with-non-shift-workers
#5
Bette Loef, Gerben Hulsegge, G C Wanda Wendel-Vos, W M Monique Verschuren, Roel C H Vermeulen, Marije F Bakker, Allard J van der Beek, Karin I Proper
OBJECTIVES: Lack of physical activity (PA) has been hypothesised as an underlying mechanism in the adverse health effects of shift work. Therefore, our aim was to compare non-occupational PA levels between shift workers and non-shift workers. Furthermore, exposure-response relationships for frequency of night shifts and years of shift work regarding non-occupational PA levels were studied. METHODS: Data of 5980 non-shift workers and 532 shift workers from the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) were used in these cross-sectional analyses...
November 21, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27865429/maternal-education-is-associated-with-disparities-in-breastfeeding-at-time-of-discharge-but-not-at-initiation-of-enteral-feeding-in-the-neonatal-intensive-care-unit
#6
Lena Carolin Herich, Marina Cuttini, Ileana Croci, Francesco Franco, Domenico Di Lallo, Dante Baronciani, Katia Fares, Giancarlo Gargano, Massimiliano Raponi, Jennifer Zeitlin
OBJECTIVE: To investigate the relationship between maternal education and breastfeeding in very preterm infants admitted to neonatal intensive care units. STUDY DESIGN: This prospective, population-based cohort study analyzed the data of all very preterm infants admitted to neonatal care during 1 year in 3 regions in Italy (Lazio, Emilia-Romagna, and Marche). The use of mothers' own milk was recorded at initial enteral feedings and at hospital discharge. We used multilevel logistic analysis to model the association between maternal education and breastfeeding outcomes, adjusting for maternal age and country of birth...
November 17, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27859648/limitations-of-serum-ferritin-to-predict-liver-iron-concentration-responses-to-deferasirox-therapy-in-patients-with-transfusion-dependent-thalassemia
#7
John B Porter, Mohsen Elalfy, Ali Taher, Yesim Aydinok, Szu-Hee Lee, Pranee Sutcharitchan, Ali El-Ali, Jackie Han, Amal El-Beshlawy
BACKGROUND: In transfusion-dependent anaemias, while absolute serum ferritin levels broadly correlate with liver iron concentration (LIC), relationships between trends in these variables are unclear. These relationships are important because serum ferritin changes are often used to adjust or switch chelation regimens when liver magnetic resonance imaging (MRI) is unavailable. OBJECTIVES AND METHODS: This post-hoc analysis of the EPIC study compared serum ferritin and LIC in 317 patients with transfusion-dependent thalassaemia before and after 1 year of deferasirox...
November 17, 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/27856457/carriers-of-the-pcsk9-proprotein-convertase-subtilisin-kexin-9-r46l-variant-are-characterized-by-an-antiatherogenic-lipoprotein-profile-assessed-by-nuclear-magnetic-resonance-spectroscopy
#8
Rutger Verbeek, Marjorie Boyer, S Matthijs Boekholdt, G Kees Hovingh, John J P Kastelein, Nicholas Wareham, Kay-Tee Khaw, Benoit J Arsenault
OBJECTIVE: Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipoprotein size and composition were measured by nuclear magnetic resonance spectroscopy in 2373 participants of the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk study...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27832394/up-to-one-third-of-breast-cancer-cases-in-post-menopausal-mediterranean-women-might-be-avoided-by-modifying-lifestyle-habits-the-epic-italy-study
#9
Giovanna Masala, Benedetta Bendinelli, Melania Assedi, Daniela Occhini, Ines Zanna, Sabina Sieri, Claudia Agnoli, Carlotta Sacerdote, Fulvio Ricceri, Amalia Mattiello, Salvatore Panico, Rosario Tumino, Graziella Frasca, Calogero Saieva, Domenico Palli
PURPOSE: Breast cancer (BC) is the most frequent cancer among women in developed countries. Physical activity (PA), body mass index (BMI), and alcohol intake have been identified as relevant lifestyle modifiable risk factors for post-menopausal BC. We aimed to evaluate the role of these factors in modulating post-menopausal BC risk and to estimate the proportion of BC cases attributable to low PA, high BMI, and alcohol taking into account non-modifiable factors. METHODS: In the Italian section of the EPIC study, 15,010 post-menopausal women were recruited and provided information about dietary and lifestyle habits including PA, smoking, reproductive history, and anthropometric measurements...
November 10, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27825320/improved-nutrition-in-adolescents-and-young-adults-after-childhood-cancer%C3%A2-inaya-study
#10
J Quidde, J von Grundherr, B Koch, C Bokemeyer, G Escherich, L Valentini, D Buchholz, G Schilling, A Stein
BACKGROUND: Multimodality treatment improves the chance of survival but increases the risk for long-term side effects in young cancer survivors, so-called" Adolescents and Young Adults"(AYAs). Compared to the general population AYAs have a 5 to 15-fold increased risk of cardiovascular morbidity. Thus, improving modifiable lifestyle risk factors is of particular importance. METHODS: The INAYA trial included AYAs between 18 and 39 years receiving an intensified individual nutrition counseling at four time points in a 3-month period based on a 3-day dietary record...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27821643/deprivation-occupational-hazards-and-perinatal-outcomes-in-pregnant-workers
#11
J-B Henrotin, M Vaissière, M Etaix, M Dziurla, A Radauceanu, S Malard, D Lafon
BACKGROUND: Recent global economic difficulties have widened social inequalities, but their impact on pregnant workers is not known. AIMS: To investigate the association between deprivation, exposure to occupational hazards and adverse perinatal outcomes in pregnant workers. METHODS: A cross-sectional study performed in 2014 in French occupational health services. Eligible workers were women who had worked during their pregnancy and had a medical visit by occupational health physicians (OHPs) after delivery and at the time of returning to work...
November 7, 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27816300/racial-variation-in-patient-reported-outcomes-following-treatment-for-localized-prostate-cancer-results-from-the-ceasar-study
#12
Mark D Tyson, JoAnn Alvarez, Tatsuki Koyama, Karen E Hoffman, Matthew J Resnick, Xiao-Cheng Wu, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Lisa E Paddock, Antoinette Stroup, Vivien W Chen, David F Penson, Daniel A Barocas
BACKGROUND: Relatively little is known about the relationship between race/ethnicity and patient-reported outcomes after contemporary treatments for localized prostate cancer. OBJECTIVE: To test the hypothesis that treatment-related changes in urinary, bowel, sexual, and hormonal function vary by race/ethnicity. DESIGN, SETTING, AND PARTICIPANTS: The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled 3708 men diagnosed with localized prostate cancer in 2011-2012...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27812016/circulating-vitamin-d-in-relation-to-cancer-incidence-and-survival-of-the-head-and-neck-and-oesophagus-in-the-epic-cohort
#13
Anouar Fanidi, David C Muller, Øivind Midttun, Per Magne Ueland, Stein Emil Vollset, Caroline Relton, Paolo Vineis, Elisabete Weiderpass, Guri Skeie, Magritt Brustad, Domenico Palli, Rosario Tumino, Sara Grioni, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Petra H Peeters, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Claire Cadeau, José María Huerta, Maria-José Sánchez, Antonio Agudo, Cristina Lasheras, J Ramón Quirós, Saioa Chamosa, Elio Riboli, Ruth C Travis, Heather Ward, Neil Murphy, Kay-Tee Khaw, Antonia Trichopoulou, Pagona Lagiou, Eleni-Maria Papatesta, Heiner Boeing, Tilman Kuehn, Verena Katzke, Annika Steffen, Anders Johansson, Paul Brennan, Mattias Johansson
Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806067/middle-stone-age-ochre-processing-and-behavioural-complexity-in-the-horn-of-africa-evidence-from-porc-epic-cave-dire-dawa-ethiopia
#14
Daniela Eugenia Rosso, Africa Pitarch Martí, Francesco d'Errico
Ochre is a common feature at Middle Stone Age (MSA) sites and has often been interpreted as a proxy for the origin of modern behaviour. However, few ochre processing tools, ochre containers, and ochre-stained artefacts from MSA contexts have been studied in detail within a theoretical framework aimed at inferring the technical steps involved in the acquisition, production and use of these artefacts. Here we analyse 21 ochre processing tools, i.e. upper and lower grindstones, and two ochre-stained artefacts from the MSA layers of Porc-Epic Cave, Dire Dawa, Ethiopia, dated to ca...
2016: PloS One
https://www.readbyqxmd.com/read/27796501/higher-serum-asymmetric-dimethylarginine-is-related-to-higher-risk-of-heart-failure-in-the-epic-potsdam-study
#15
Janine Wirth, Dorothee Atzler, Romina di Giuseppe, Kathrin Cordts, Juliane Menzel, Rainer H Böger, Heiner Boeing, Cornelia Weikert, Edzard Schwedhelm
L-Arginine is the substrate of endothelial nitric oxide (NO) synthase forming NO which inherits various biological cardio-protective functions. The dimethylarginines asymmetric (ADMA) and symmetric dimethylarginine (SDMA) can impair the synthesis of NO and are elevated in patients with cardiovascular disease, including heart failure (HF). We investigated the association between dimethylarginines and HF risk in a case-cohort study of the European Prospective Investigation into Cancer and Nutrition (n = 27,548), comprising a random subcohort (n = 2224 including 19 HF cases), and all remaining HF cases (n = 176) that occurred within 8...
October 28, 2016: Amino Acids
https://www.readbyqxmd.com/read/27795345/improved-detection-of-respiratory-pathogens-using-high-quality-sputum-with-taqman-array-card-technology
#16
Bernard J Wolff, Anna M Bramley, Kathleen A Thurman, Cynthia G Whitney, Brett Whitaker, Wesley H Self, Sandra R Arnold, Christopher Trabue, Richard G Wunderink, Jon McCullers, Kathryn M Edwards, Seema Jain, Jonas M Winchell
New diagnostic platforms often use naso- or oropharyngeal (NP/OP) swabs for pathogen detection for patients hospitalized with community-acquired pneumonia (CAP). We applied multi-pathogen testing to high-quality sputum specimens to determine if more pathogens could be identified relative to NP/OP swabs. Children (<18 years old) and adults hospitalized with CAP were enrolled over 2.5 years through the Etiology of Pneumonia in the Community (EPIC) study. NP/OP specimens with matching high-quality sputum (defined as ≤10 epithelial cells/low power field [lpf] and ≥25 white blood cells/lpf or a q-score definition of 2+) were tested by TaqMan Array Card (TAC), a multi-pathogen real-time polymerase chain reaction (PCR) detection platform...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27795341/serology-enhances-molecular-diagnosis-of-respiratory-virus-infections-other-than-influenza-in-children-and-adults-hospitalized-with-community-acquired-pneumonia
#17
Yange Zhang, Senthilkumar K Sakthivel, Anna Bramley, Seema Jain, Amber Haynes, James D Chappell, Weston Hymas, Noel Lenny, Anami Patel, Chao Qi, Krow Ampofo, Sandra R Arnold, Wesley H Self, Derek J Williams, David Hillyard, Evan J Anderson, Carlos G Grijalva, Yuwei Zhu, Richard G Wunderink, Kathryn M Edwards, Andrew T Pavia, Jonathan A McCullers, Dean D Erdman
Both molecular and serological assays have been used previously to determine the etiology of community-acquired pneumonia (CAP). However, the correlation of these methods and added diagnostic value of serology has not been fully evaluated. Using data from patients enrolled in the Centers for Disease Control and Prevention Etiology of Pneumonia in the Community (EPIC) study, we compared real-time RT-PCR and serology for diagnosis of respiratory syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza viruses 1-3 (PIV) and adenovirus (AdV) infections...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27794558/efficient-detection-of-differentially-methylated-regions-using-dimmer
#18
Diogo Almeida, Ida Skov, Artur Silva, Fabio Vandin, Qihua Tan, Richard Röttger, Jan Baumbach
MOTIVATION: Epigenome-wide association studies (EWAS) generate big epidemiological data sets. They aim for detecting differentially methylated DNA regions that are likely to influence transcriptional gene activity and, thus, the regulation of metabolic processes. The by far most widely used technology is the Illumina Methylation BeadChip, which measures the methylation levels of 450 (850) thousand cytosines, in the CpG dinucleotide context in a set of patients compared to a control group...
October 29, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27789618/zinc-deficiency-is-associated-with-depressive-symptoms-results-from-the-berlin-aging-study-ii
#19
Alissa Jung, Dominik Spira, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Kristina Norman
BACKGROUND: Zinc plays an important role for behavioral and mental function, maintaining the correct functions of intracellular signal transduction, cellular and trans-membrane transport, protein synthesis, and antioxidant system. We investigated both dietary zinc intake and plasma zinc levels and the correlation with depressive symptoms in a large sample of community-dwelling old. DESIGN: One thousand five hundred fourteen older people (aged 60-84 years, 772 women) from the Berlin Aging Study II were included...
October 27, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27776654/mdct-of-acute-pancreatitis-intraindividual-comparison-of-single-phase-versus-dual-phase-mdct-for-initial-assessment-of-acute-pancreatitis-using-different-ct-scoring-systems
#20
Maxim Avanesov, Julius M Weinrich, Thomas Kraus, Thorsten Derlin, Gerhard Adam, Jin Yamamura, Murat Karul
OBJECTIVES: The purpose of the retrospective study was to evaluate the additional value of dual-phase multidetector computed tomography (MDCT) protocols over a single-phase protocol on initial MDCT in patients with acute pancreatitis using three CT-based pancreatitis severity scores with regard to radiation dose. METHODS: In this retrospective, IRB approved study MDCT was performed in 102 consecutive patients (73 males; 55years, IQR48-64) with acute pancreatitis...
November 2016: European Journal of Radiology
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