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https://www.readbyqxmd.com/read/28633629/prevalence-of-and-risk-factors-for-severe-cognitive-and-sleep-symptoms-in-me-cfs-and-ms
#1
Vageesh Jain, Amit Arunkumar, Caroline Kingdon, Eliana Lacerda, Luis Nacul
BACKGROUND: There are considerable phenotypic and neuroimmune overlaps between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS). While the precise aetiologies of both MS and ME/CFS are unclear, evidence suggests that deterioration in cognitive function is widely prevalent in patients with either condition. Little is known about differing risk factors or exposures, which may lead to severe cognitive or sleep symptoms. This study aims to gauge the extent of cognitive and sleep symptoms in ME/CFS and MS patients participating in the UK ME/CFS Biobank and identify the characteristics of those experiencing severe symptoms...
June 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28626828/contribution-of-risk-factors-to-excess-mortality-in-isolated-and-lonely-individuals-an-analysis-of-data-from-the-uk-biobank-cohort-study
#2
Marko Elovainio, Christian Hakulinen, Laura Pulkki-Råback, Marianna Virtanen, Kim Josefsson, Markus Jokela, Jussi Vahtera, Mika Kivimäki
BACKGROUND: The associations of social isolation and loneliness with premature mortality are well known, but the risk factors linking them remain unclear. We sought to identify risk factors that might explain the increased mortality in socially isolated and lonely individuals. METHODS: We used prospective follow-up data from the UK Biobank cohort study to assess self-reported isolation (a three-item scale) and loneliness (two questions). The main outcomes were all-cause and cause-specific mortality...
June 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28601812/cardiovascular-and-type-2-diabetes-morbidity-and-all-cause-mortality-among-diverse-chronic-inflammatory-disorders
#3
Alex Dregan, Phil Chowienczyk, Mariam Molokhia
OBJECTIVES: The present study aimed to assess the relationship between inflammatory disorders with cardiometabolic diseases and mortality within a community-based population. METHODS: The UK Biobank data were used to conduct two investigations: a cross-sectional study to estimate cardiometabolic risk and a prospective cohort study to estimate mortality risk. Binary regression analyses were used to model the association between coronary heart disease, stroke, type 2 diabetes, venous thromboembolism and peripheral artery disease diagnoses with seven inflammatory disorders (eg, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, ankylosing spondylitis (AS), systemic vasculitis, Crohn's disease and ulcerative colitis (UC))...
June 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28584231/identification-of-15-novel-risk-loci-for-coronary-artery-disease-and-genetic-risk-of-recurrent-events-atrial-fibrillation-and-heart-failure
#4
Niek Verweij, Ruben N Eppinga, Yanick Hagemeijer, Pim van der Harst
Coronary artery disease (CAD) is the major cause of morbidity and mortality in the world. Identification of novel genetic determinants may provide new opportunities for developing innovative strategies to predict, prevent and treat CAD. Therefore, we meta-analyzed independent genetic variants passing P <× 10(-5) in CARDIoGRAMplusC4D with novel data made available by UK Biobank. Of the 161 genetic variants studied, 71 reached genome wide significance (p < 5 × 10(-8)) including 15 novel loci. These novel loci include multiple genes that are involved in angiogenesis (TGFB1, ITGB5, CDH13 and RHOA) and 2 independent variants in the TGFB1 locus...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28572633/cognitive-ability-and-physical-health-a-mendelian-randomization-study
#5
Saskia P Hagenaars, Catharine R Gale, Ian J Deary, Sarah E Harris
Causes of the association between cognitive ability and health remain unknown, but may reflect a shared genetic aetiology. This study examines the causal genetic associations between cognitive ability and physical health. We carried out two-sample Mendelian randomization analyses using the inverse-variance weighted method to test for causality between later life cognitive ability, educational attainment (as a proxy for cognitive ability in youth), BMI, height, systolic blood pressure, coronary artery disease, and type 2 diabetes using data from six independent GWAS consortia and the UK Biobank sample (N = 112 151)...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28566307/central-adiposity-and-the-overweight-risk-paradox-in-aging-follow-up-of-130-473-uk-biobank-participants
#6
Kirsty Bowman, Janice L Atkins, João Delgado, Katarina Kos, George A Kuchel, Alessandro Ble, Luigi Ferrucci, David Melzer
Background: For older groups, being overweight [body mass index (BMI; in kg/m(2)): 25 to <30] is reportedly associated with a lower or similar risk of mortality than being normal weight (BMI: 18.5 to <25). However, this "risk paradox" is partly explained by smoking and disease-associated weight loss. This paradox may also arise from BMI failing to measure fat redistribution to a centralized position in later life.Objective: This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD)...
May 31, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28559460/development-of-a-cancer-risk-prediction-tool-for-use-in-the-uk-primary-care-and-community-settings
#7
Artitaya Lophatananon, Juliet A Usher-Smith, Jackie Campbell, Joanne Warcaba, Barbora Silarova, Erika A Waters, Graham A Colditz, Kenneth Muir
Several multivariable risk prediction models have been developed to asses an individual's risk of developing specific cancers. Such models can be used in a variety of settings for prevention, screening and guiding investigations and treatments. Models aimed at predicting future disease risk that contains lifestyle factors may be of particular use for targeting health promotion activities at an individual level. This type of cancer risk prediction is not yet available in the UK. We have adopted the approach used by the well-established U...
May 30, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28556459/does-coffee-consumption-impact-on-heaviness-of-smoking
#8
Jennifer J Ware, Julie-Anne Tanner, Amy E Taylor, Zhao Bin, Philip Haycock, Jack Bowden, Peter J Rogers, George Davey Smith, Rachel F Tyndale, Marcus R Munafo
BACKGROUND AND AIMS: Coffee consumption and cigarette smoking are strongly associated, but whether this association is causal remains unclear. We sought to: 1) determine whether coffee consumption causally influences cigarette smoking, 2) estimate the magnitude of any association, and 3) explore potential mechanisms. DESIGN: We used Mendelian randomization (MR) analyses of observational data, using publicly available summarised data from the Tobacco and Genetics (TAG) consortium, individual level data from the UK Biobank, and in vitro experiments of candidate compounds...
May 27, 2017: Addiction
https://www.readbyqxmd.com/read/28551493/residential-greenness-and-adiposity-findings-from-the-uk-biobank
#9
Chinmoy Sarkar
BACKGROUND: With the rapid urbanization and prevailing obesity pandemic, the role of residential green exposures in obesity prevention has gained renewed focus. The study investigated the effects of residential green exposures on adiposity using a large and diverse population sample drawn from the UK Biobank. MATERIALS AND METHODS: This was a population based cross-sectional study of 333,183 participants aged 38-73years with individual-level data on residential greenness and built environment exposures...
May 25, 2017: Environment International
https://www.readbyqxmd.com/read/28531320/uk-biobank-opportunities-for-cardiovascular-research
#10
Thomas J Littlejohns, Cathie Sudlow, Naomi E Allen, Rory Collins
No abstract text is available yet for this article.
May 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28529332/adiposity-and-grip-strength-as-long-term-predictors-of-objectively-measured-physical-activity-in-93%C3%A2-015-adults-the-uk-biobank-study
#11
Y Kim, T White, K Wijndaele, S J Sharp, N J Wareham, S Brage
BACKGROUND/OBJECTIVES: Fatness and fitness are associated with physical activity (PA) but less is known about the prospective associations of adiposity and muscle strength with PA. This study aimed to determine longitudinal associations of body mass index (BMI), waist circumference (WC) and grip strength (GS) with objectively measured PA. SUBJECTS/METHODS: Data are from the UK Biobank study. At baseline (2006-2010), BMI, WC and GS were objectively measured. At follow-up (2013-2015), a sub-sample of 93 015 participants (52 161 women) wore a tri-axial accelerometer on the dominant wrist for 7 days...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28488939/differences-in-morning-evening-type-and-sleep-duration-between-black-and-white-adults-results-from-a-propensity-matched-uk-biobank-sample
#12
Susan Kohl Malone, Freda Patterson, Alicia Lozano, Alexandra Hanlon
Biological evidence suggests that ethno-racial differences in morning-evening type are possible, whereby Blacks may be more likely to be morning type compared to Whites. However, population-level evidence of ethno-racial difference in morning-evening type is limited. In an earlier study, we reported that morning type was more prevalent in Blacks compared to Whites in the United Kingdom (UK) Biobank cohort (N = 439 933). This study aimed to determine if these ethno-racial differences persisted after accounting for an even broader range of social, environmental and individual characteristics and employing an analytic approach that simulates randomization in observational data, propensity score modeling...
May 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28486474/vitamin-d-levels-and-susceptibility-to-asthma-elevated-immunoglobulin-e-levels-and-atopic-dermatitis-a-mendelian-randomization-study
#13
Despoina Manousaki, Lavinia Paternoster, Marie Standl, Miriam F Moffatt, Martin Farrall, Emmanuelle Bouzigon, David P Strachan, Florence Demenais, Mark Lathrop, William O C M Cookson, J Brent Richards
BACKGROUND: Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological associations, if true, would have public health importance, since vitamin D insufficiency is common and correctable. METHODS AND FINDINGS: We aimed to test whether genetically lowered vitamin D levels were associated with risk of asthma, atopic dermatitis, or elevated serum IgE levels, using Mendelian randomization (MR) methodology to control bias owing to confounding and reverse causation...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28480974/comorbidities-and-medications-of-patients-with-chronic-hepatitis-c-under-specialist-care-in-the-uk
#14
Benjamin Hudson, Alex J Walker, William L Irving
Designing services with the capacity and expertise to meet the needs of the chronic hepatitis C (CHC) population in the era of direct acting antivirals (DAAs), and widening access to such treatments, requires detailed understanding of the characteristics and healthcare needs of the existing patient population. In this retrospective analysis of data from the National HCV Research UK Biobank between March 2012-October 2014 the characteristics of the CHC population currently under specialist care in the UK were evaluated - with specific focus upon use of medications, adverse lifestyle choices, and comorbidities...
May 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28454540/low-physical-activity-high-television-viewing-and-poor-sleep-duration-cluster-in-overweight-and-obese-adults-a-cross-sectional-study-of-398-984-participants-from-the-uk-biobank
#15
Sophie Cassidy, Josephine Y Chau, Michael Catt, Adrian Bauman, Michael I Trenell
BACKGROUND: An unhealthy lifestyle is one of the greatest contributors to obesity. A number of behaviours are linked with obesity, but are often measured separately. The UK Biobank cohort of >500,000 participants allows us to explore these behaviours simultaneously. We therefore aimed to compare physical activity, television (TV) viewing and sleep duration across body mass index (BMI) categories in a large sample of UK adults. METHODS: UK Biobank participants were recruited and baseline measures were taken between 2007 and 2010 and data analysis was performed in 2015...
April 28, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28445545/correction-characterisation-of-liver-fat-in-the-uk-biobank-cohort
#16
Henry R Wilman, Matt Kelly, Steve Garratt, Paul M Matthews, Matteo Milanesi, Amy Herlihy, Michael Gyngell, Stefan Neubauer, Jimmy D Bell, Rajarshi Banerjee, E Louise Thomas
[This corrects the article DOI: 10.1371/journal.pone.0172921.].
2017: PloS One
https://www.readbyqxmd.com/read/28424154/association-between-active-commuting-and-incident-cardiovascular-disease-cancer-and-mortality-prospective-cohort-study
#17
MULTICENTER STUDY
Carlos A Celis-Morales, Donald M Lyall, Paul Welsh, Jana Anderson, Lewis Steell, Yibing Guo, Reno Maldonado, Daniel F Mackay, Jill P Pell, Naveed Sattar, Jason M R Gill
Objective To investigate the association between active commuting and incident cardiovascular disease (CVD), cancer, and all cause mortality.Design Prospective population based study. Setting UK Biobank.Participants 263 450 participants (106 674 (52%) women; mean age 52.6), recruited from 22 sites across the UK. The exposure variable was the mode of transport used (walking, cycling, mixed mode v non-active (car or public transport)) to commute to and from work on a typical day.Main outcome measures Incident (fatal and non-fatal) CVD and cancer, and deaths from CVD, cancer, or any causes...
April 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28418403/assessing-the-presence-of-shared-genetic-architecture-between-alzheimer-s-disease-and-major-depressive-disorder-using-genome-wide-association-data
#18
J Gibson, T C Russ, M J Adams, T-K Clarke, D M Howard, L S Hall, A M Fernandez-Pujals, E M Wigmore, C Hayward, G Davies, A D Murray, B H Smith, D J Porteous, I J Deary, A M McIntosh
Major depressive disorder (MDD) and Alzheimer's disease (AD) are both common in older age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses suggest that a history of depression increases risk of subsequent AD, although the basis of this relationship is uncertain. Both illnesses are polygenic, and shared genetic risk factors could explain some of the observed association. We used genotype data to test whether MDD and AD have an overlapping polygenic architecture in two large population-based cohorts, Generation Scotland's Scottish Family Health Study (GS:SFHS; N=19 889) and UK Biobank (N=25 118), and whether age of depression onset influences any relationship...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28411266/genetic-variation-at-the-sulfonylurea-receptor-type-2-diabetes-and-coronary-heart-disease
#19
Connor A Emdin, Derek Klarin, Pradeep Natarajan, Jose C Florez, Sekar Kathiresan, Amit V Khera
Despite widespread clinical use in the treatment of type 2 diabetes, the impact of sulfonylurea therapy on cardiovascular outcomes remains uncertain. Studies of naturally occurring genetic variation can be used to anticipate the expected clinical consequences of a pharmacologic therapy. A common missense variant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S) promotes closure of the target channel of sulfonylurea therapy and is associated with increased insulin secretion, thus mimicking the effects of sulfonylurea therapy...
April 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28388634/phenome-wide-heritability-analysis-of-the-uk-biobank
#20
Tian Ge, Chia-Yen Chen, Benjamin M Neale, Mert R Sabuncu, Jordan W Smoller
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common genetic variants (SNP heritability) across a broad phenotypic spectrum. Here, we present a computationally and memory efficient heritability estimation method that can handle large sample sizes, and report the SNP heritability for 551 complex traits derived from the interim data release (152,736 subjects) of the large-scale, population-based UK Biobank, comprising both quantitative phenotypes and disease codes...
April 2017: PLoS Genetics
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