keyword
MENU ▼
Read by QxMD icon Read
search

uk biobank

keyword
https://www.readbyqxmd.com/read/28445545/correction-characterisation-of-liver-fat-in-the-uk-biobank-cohort
#1
Henry R Wilman, Matt Kelly, Steve Garratt, Paul M Matthews, Matteo Milanesi, Amy Herlihy, Michael Gyngell, Stefan Neubauer, Jimmy D Bell, Rajarshi Banerjee, E Louise Thomas
[This corrects the article DOI: 10.1371/journal.pone.0172921.].
2017: PloS One
https://www.readbyqxmd.com/read/28424154/association-between-active-commuting-and-incident-cardiovascular-disease-cancer-and-mortality-prospective-cohort-study
#2
Carlos A Celis-Morales, Donald M Lyall, Paul Welsh, Jana Anderson, Lewis Steell, Yibing Guo, Reno Maldonado, Daniel F Mackay, Jill P Pell, Naveed Sattar, Jason M R Gill
Objective To investigate the association between active commuting and incident cardiovascular disease (CVD), cancer, and all cause mortality.Design Prospective population based study. Setting UK Biobank.Participants 263 450 participants (106 674 (52%) women; mean age 52.6), recruited from 22 sites across the UK. The exposure variable was the mode of transport used (walking, cycling, mixed mode v non-active (car or public transport)) to commute to and from work on a typical day.Main outcome measures Incident (fatal and non-fatal) CVD and cancer, and deaths from CVD, cancer, or any causes...
April 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28418403/assessing-the-presence-of-shared-genetic-architecture-between-alzheimer-s-disease-and-major-depressive-disorder-using-genome-wide-association-data
#3
J Gibson, T C Russ, M J Adams, T-K Clarke, D M Howard, L S Hall, A M Fernandez-Pujals, E M Wigmore, C Hayward, G Davies, A D Murray, B H Smith, D J Porteous, I J Deary, A M McIntosh
Major depressive disorder (MDD) and Alzheimer's disease (AD) are both common in older age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses suggest that a history of depression increases risk of subsequent AD, although the basis of this relationship is uncertain. Both illnesses are polygenic, and shared genetic risk factors could explain some of the observed association. We used genotype data to test whether MDD and AD have an overlapping polygenic architecture in two large population-based cohorts, Generation Scotland's Scottish Family Health Study (GS:SFHS; N=19 889) and UK Biobank (N=25 118), and whether age of depression onset influences any relationship...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28411266/genetic-variation-at-the-sulfonylurea-receptor-type-2-diabetes-and-coronary-heart-disease
#4
Connor A Emdin, Derek Klarin, Pradeep Natarajan, Jose C Florez, Sekar Kathiresan, Amit V Khera
Despite widespread clinical use in the treatment of type 2 diabetes, the impact of sulfonylurea therapy on cardiovascular outcomes remains uncertain. Studies of naturally occurring genetic variation can be used to anticipate the expected clinical consequences of a pharmacologic therapy. A common missense variant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S) promotes closure of the target channel of sulfonylurea therapy and is associated with increased insulin secretion, thus mimicking the effects of sulfonylurea therapy...
April 14, 2017: Diabetes
https://www.readbyqxmd.com/read/28388634/phenome-wide-heritability-analysis-of-the-uk-biobank
#5
Tian Ge, Chia-Yen Chen, Benjamin M Neale, Mert R Sabuncu, Jordan W Smoller
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common genetic variants (SNP heritability) across a broad phenotypic spectrum. Here, we present a computationally and memory efficient heritability estimation method that can handle large sample sizes, and report the SNP heritability for 551 complex traits derived from the interim data release (152,736 subjects) of the large-scale, population-based UK Biobank, comprising both quantitative phenotypes and disease codes...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28387438/the-cognitive-footprint-of-psychiatric-and-neurological-conditions-cross-sectional-study-in-the-uk-biobank-cohort
#6
B Cullen, D J Smith, I J Deary, J J Evans, J P Pell
OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. METHOD: Cross-sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self-reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group...
April 7, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28386029/analysis-of-bovine-viral-diarrhoea-virus-biobank-and-sequence-database-to-support-eradication-in-scotland
#7
G C Russell, D M Grant, S Lycett, C Bachofen, G L Caldow, P D Burr, K Davie, N Ambrose, G J Gunn, R N Zadoks
Samples from bovine viral diarrhoea virus (BVDV)-positive cattle were gathered by Scottish diagnostic laboratories and used to produce a Biobank of samples with associated location and identification data in support of the Scottish BVDV eradication scheme. The samples were subject to direct amplification and sequencing of the 5'-untranslated region (5'-UTR) to define the viral types and subtypes present. From 2693 samples collected prior to 2016, approximately 2300 sequences were obtained, representing 8 BVDV type 1 subtypes...
April 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28379579/discovery-of-novel-heart-rate-associated-loci-using-the-exome-chip
#8
Marten E van den Berg, Helen R Warren, Claudia P Cabrera, Niek Verweij, Borbala Mifsud, Jeffrey Haessler, Nathan A Bihlmeyer, Yi-Ping Fu, Stefan Weiss, Henry J Lin, Niels Grarup, Ruifang Li-Gao, Giorgio Pistis, Nabi Shah, Jennifer A Brody, Martina Müller-Nurasyid, Honghuang Lin, Hao Mei, Albert V Smith, Leo-Pekka Lyytikäinen, Leanne M Hall, Jessica van Setten, Stella Trompet, Bram P Prins, Aaron Isaacs, Farid Radmanesh, Jonathan Marten, Aiman Entwistle, Jan A Kors, Claudia T Silva, Alvaro Alonso, Joshua C Bis, Rudolf de Boer, Hugoline G de Haan, Renée de Mutsert, George Dedoussis, Anna F Dominiczak, Alex S F Doney, Patrick T Ellinor, Ruben N Eppinga, Stephan B Felix, Xiuqing Guo, Yanick Hagemeijer, Torben Hansen, Tamara B Harris, Susan R Heckbert, Paul L Huang, Shih-Jen Hwang, Mika Kähönen, Jørgen K Kanters, Ivana Kolcic, Lenore J Launer, Man Li, Jie Yao, Allan Linneberg, Simin Liu, Peter W Macfarlane, Massimo Mangino, Andrew D Morris, Antonella Mulas, Alison D Murray, Christopher P Nelson, Marco Orrú, Sandosh Padmanabhan, Annette Peters, David J Porteous, Neil Poulter, Bruce M Psaty, Lihong Qi, Olli T Raitakari, Fernando Rivadeneira, Carolina Roselli, Igor Rudan, Naveed Sattar, Peter Sever, Moritz F Sinner, Elsayed Z Soliman, Timothy D Spector, Alice V Stanton, Kathleen E Stirrups, Kent D Taylor, Martin D Tobin, André Uitterlinden, Ilonca Vaartjes, Arno W Hoes, Peter van der Meer, Uwe Völker, Melanie Waldenberger, Zhijun Xie, Magdalena Zoledziewska, Andrew Tinker, Ozren Polasek, Jonathan Rosand, Yalda Jamshidi, Cornelia M van Duijn, Eleftheria Zeggini, J Wouter Jukema, Folkert W Asselbergs, Nilesh J Samani, Terho Lehtimäki, Vilmundur Gudnason, James Wilson, Steven A Lubitz, Stefan Kääb, Nona Sotoodehnia, Mark J Caulfield, Colin N A Palmer, Serena Sanna, Dennis O Mook-Kanamori, Panos Deloukas, Oluf Pedersen, Jerome I Rotter, Marcus Dörr, Chris J O'Donnell, Caroline Hayward, Dan E Arking, Charles Kooperberg, Pim van der Harst, Mark Eijgelsheim, Bruno H Stricker, Patricia B Munroe
Background Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. GWAS analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation.Aim To discover new genetic loci associated with heart rate from Exome Chip meta-analyses.Methods Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association results from 104,452 European-ancestry individuals from 30 cohorts, genotyped using the Exome Chip...
April 3, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28373160/genetic-analysis-of-venous-thromboembolism-in-uk-biobank-identifies-the-zfpm2-locus-and-implicates-obesity-as-a-causal-risk-factor
#9
Derek Klarin, Connor A Emdin, Pradeep Natarajan, Mark F Conrad, Sekar Kathiresan
BACKGROUND: UK Biobank is the world's largest repository for phenotypic and genotypic information for individuals of European ancestry. Here, we leverage UK Biobank to understand the inherited basis for venous thromboembolism (VTE), a leading cause of cardiovascular mortality. METHODS AND RESULTS: We identified 3290 VTE cases and 116 868 controls through billing code-based phenotyping. We performed a genome-wide association study for VTE with ≈9 000 000 imputed single-nucleotide polymorphisms...
April 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28365468/intelligence-and-neuroticism-in-relation-to-depression-and-psychological-distress-evidence-from-two-large-population-cohorts
#10
L B Navrady, S J Ritchie, S W Y Chan, D M Kerr, M J Adams, E H Hawkins, D Porteous, I J Deary, C R Gale, G D Batty, A M McIntosh
BACKGROUND: Neuroticism is a risk factor for selected mental and physical illnesses and is inversely associated with intelligence. Intelligence appears to interact with neuroticism and mitigate its detrimental effects on physical health and mortality. However, the inter-relationships of neuroticism and intelligence for major depressive disorder (MDD) and psychological distress has not been well examined. METHODS: Associations and interactions between neuroticism and general intelligence (g) on MDD, self-reported depression, and psychological distress were examined in two population-based cohorts: Generation Scotland: Scottish Family Health Study (GS:SFHS, n=19,200) and UK Biobank (n=90,529)...
January 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28364486/genetic-basis-of-chronotype-in-humans-insights-from-three-landmark-gwas
#11
David A Kalmbach, Logan D Schneider, Joseph Cheung, Sarah J Bertrand, Thiruchelvam Kariharan, Allan I Pack, Philip R Gehrman
Study Objectives: Chronotype, or diurnal preference, refers to behavioral manifestations of the endogenous circadian system that governs preferred timing of sleep and wake. As variations in circadian timing and system perturbations are linked to disease development, the fundamental biology of chronotype has received attention for its role in the regulation and dysregulation of sleep and related illnesses. Family studies indicate that chronotype is a heritable trait, thus directing attention toward its genetic basis...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28363219/associations-between-single-and-multiple-cardiometabolic-diseases-and-cognitive-abilities-in-474-129-uk-biobank-participants
#12
Donald M Lyall, Carlos A Celis-Morales, Jana Anderson, Jason M R Gill, Daniel F Mackay, Andrew M McIntosh, Daniel J Smith, Ian J Deary, Naveed Sattar, Jill P Pell
Aims: Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there are limited data on whether having more than one of these conditions is associated with additive effects. We aimed to quantify the magnitude of their associations with non-demented cognitive abilities and determine the extent to which these associations were additive. Methods and results: We examined cognitive test scores in domains of reasoning, information processing speed and memory, included as part of the baseline UK Biobank cohort assessment (N = 474 129 with relevant data), adjusting for a range of potentially confounding variables...
February 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28362817/cis-eqtl-based-trans-ethnic-meta-analysis-reveals-novel-genes-associated-with-breast-cancer-risk
#13
Joshua D Hoffman, Rebecca E Graff, Nima C Emami, Caroline G Tai, Michael N Passarelli, Donglei Hu, Scott Huntsman, Dexter Hadley, Lancelote Leong, Arunabha Majumdar, Noah Zaitlen, Elad Ziv, John S Witte
Breast cancer is the most common solid organ malignancy and the most frequent cause of cancer death among women worldwide. Previous research has yielded insights into its genetic etiology, but there remains a gap in the understanding of genetic factors that contribute to risk, and particularly in the biological mechanisms by which genetic variation modulates risk. The National Cancer Institute's "Up for a Challenge" (U4C) competition provided an opportunity to further elucidate the genetic basis of the disease...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28341684/association-between-physical-activity-and-body-fat-percentage-with-adjustment-for-bmi-a-large-cross-sectional-analysis-of-uk-biobank
#14
Kathryn E Bradbury, Wenji Guo, Benjamin J Cairns, Miranda E G Armstrong, Timothy J Key
OBJECTIVES: The objective of this study was to examine if, in the general population, physically active adults have less body fat after taking body mass index (BMI) into account. DESIGN: A cross-sectional analysis of participants recruited into UK Biobank in 2006-2010. SETTING: UK Biobank assessment centres throughout the UK. PARTICIPANTS: 119 230 men and 140 578 women aged 40-69 years, with complete physical activity information, and without a self-reported long-term illness, disability or infirmity...
March 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28338838/cohort-profile-the-hepatitis-c-virus-hcv-research-uk-clinical-database-and-biobank
#15
J McLauchlan, H Innes, J F Dillon, G Foster, E Holtham, S McDonald, B Wilkes, S J Hutchinson, W L Irving
No abstract text is available yet for this article.
February 27, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28338774/pleiotropy-robust-mendelian-randomization
#16
Hans van Kippersluis, Cornelius A Rietveld
Background: The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of genetic variants, a fundamental assumption of Mendelian randomization (the exclusion restriction) can always be contested...
February 22, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28334838/neutrophil-mediated-il-6-receptor-trans-signaling-and-the-risk-of-chronic-obstructive-pulmonary-disease-and-asthma
#17
Neda Farahi, Ellie Paige, Jozef Balla, Emily Prudence, Ricardo C Ferreira, Mark Southwood, Sarah L Appleby, Per Bakke, Amund Gulsvik, Augusto A Litonjua, David Sparrow, Edwin K Silverman, Michael H Cho, John Danesh, Dirk S Paul, Daniel F Freitag, Edwin R Chilvers
The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary disease (COPD) has not been investigated. The aims of this study were to evaluate whether there is an association between Asp358Ala and COPD or asthma risk, and to explore the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effects in the lung. We undertook logistic regression using data from the UK Biobank and the ECLIPSE COPD cohort...
April 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28299370/change-in-commute-mode-and-body-mass-index-prospective-longitudinal-evidence-from-uk-biobank
#18
Ellen Flint, Elizabeth Webb, Steven Cummins
BACKGROUND: Insufficient physical activity is a determinant of obesity and cardiovascular disease. Active travel to work has declined in high-income countries in recent decades. We aimed to determine which socioeconomic and demographic characteristics predicted switching to or from active commuting, whether switching from passive to active commuting (or the reverse) independently predicts change in objectively measured body-mass index (BMI), and to ascertain whether any association is attenuated by socioeconomic, demographic, or behavioural factors...
December 2016: Lancet. Public Health
https://www.readbyqxmd.com/read/28251931/sleep-characteristics-modify-the-association-of-genetic-predisposition-with-obesity-and-anthropometric-measurements-in-119-679-uk-biobank-participants
#19
Carlos Celis-Morales, Donald M Lyall, Yibing Guo, Lewis Steell, Daniel Llanas, Joey Ward, Daniel F Mackay, Stephany M Biello, Mark Es Bailey, Jill P Pell, Jason Mr Gill
Background: Obesity is a multifactorial condition influenced by genetics, lifestyle, and environment.Objective: We investigated whether the association of a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI) and waist circumference (WC) was modified by sleep characteristics.Design: This study included cross-sectional data from 119,859 white European adults, aged 37-73 y, participating in the UK Biobank. Interactions of GPRS-obesity and sleep characteristics (sleep duration, chronotype, day napping, and shift work) with their effects on BMI and WC were investigated...
April 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28241076/characterisation-of-liver-fat-in-the-uk-biobank-cohort
#20
Henry R Wilman, Matt Kelly, Steve Garratt, Paul M Matthews, Matteo Milanesi, Amy Herlihy, Micheal Gyngell, Stefan Neubauer, Jimmy D Bell, Rajarshi Banerjee, E Louise Thomas
Non-alcoholic fatty liver disease and the risk of progression to steatohepatitis, cirrhosis and hepatocellular carcinoma have been identified as major public health concerns. We have demonstrated the feasibility and potential value of measuring liver fat content by magnetic resonance imaging (MRI) in a large population in this study of 4,949 participants (aged 45-73 years) in the UK Biobank imaging enhancement. Despite requirements for only a single (≤3min) scan of each subject, liver fat was able to be measured as the MRI proton density fat fraction (PDFF) with an overall success rate of 96...
2017: PloS One
keyword
keyword
44565
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"