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Pneumococcal vaccine

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https://www.readbyqxmd.com/read/29147880/targeted-physician-education-and-standardizing-documentation-improves-documented-reporting-with-inflammatory-bowel-disease-quality-measures-in-a-large-academic-and-private-practice
#1
Joseph D Feuerstein, Konstantinos Papamichael, Sara Popejoy, Adam Nadelson, Jeffrey J Lewandowski, Kathy Geissler, Manuel Martinez-Vazquez, Daniel A Leffler, Kim Ariyabuddhiphongs, Chandrashekhar Thukral, Adam S Cheifetz
BACKGROUND: Prior studies have shown poor compliance with quality measures for IBD at academic and private practices. We sought to provide focused interventions to improve compliance and documentation with the IBD measures. METHODS: Two centers, academic practice (AP) and private practice (PP), initially reviewed their compliance with eight established IBD quality measures in consecutive charts. A multi-faceted intervention was developed to improve awareness and documentation of these measures...
November 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29146483/why-should-we-recommend-pneumococcal-vaccine-in-patients-with-chronic-heart-diseases
#2
Fernando González-Romo, Vivencio Barrios
No abstract text is available yet for this article.
November 13, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29146381/impact-of-infant-pneumococcal-conjugate-vaccination-on-community-acquired-pneumonia-hospitalization-in-all-ages-in-the-netherlands
#3
A M M van Deursen, T M Schurink-Van't Klooster, W H Man, J van de Kassteele, A B van Gageldonk-Lafeber, P C J L Bruijning-Verhagen, H E de Melker, E A M Sanders, M J Knol
BACKGROUND: The long-term impact of pneumococcal conjugate vaccines on pneumonia hospitalizations in all age-groups varies between countries. In the Netherlands, the 7-valent pneumococcal conjugate vaccine (PCV7) was implemented for newborns in 2006 and replaced by PCV10 in 2011. We assessed the impact of PCVs on community-acquired pneumonia (CAP) hospitalization rates in all age-groups. METHODS: A time series analysis using Poisson regression was performed on 155,994 CAP hospitalizations...
November 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29146380/inclusion-of-the-value-of-herd-immunity-in-economic-evaluations-of-vaccines-a-systematic-review-of-methods-used
#4
REVIEW
Liv S Nymark, Tarang Sharma, Alexander Miller, Ulrika Enemark, Ulla Kou Griffiths
OBJECTIVE: The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS: We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additionally searched PubMed/MEDLINE and Embase for 2007-2015. Studies were classified according to modelling approach used. Methods for estimating herd immunity effects were described, in particular for the static models...
November 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29145619/intranasal-immunization-with-an-attenuated-pep27-mutant-provides-protection-from-influenza-virus-and-secondary-pneumococcal-infections
#5
Seung Han Seon, Jung Ah Choi, Eunji Yang, Sukneung Pyo, Man Ki Song, Dong-Kwon Rhee
During influenza pandemics, secondary pneumococcal infections cause excessive mortality. However, the current pneumococcal polysaccharide conjugate vaccine, PCV 13, provides only limited protection against secondary infection. Therefore, a more effective pneumococcal vaccine is required to protect against secondary pneumococcal infections. Here, intranasal immunization with an attenuated pneumococcal pep27 mutant provides protection from influenza virus infection, and also from secondary pneumococcal challenge...
November 14, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29135332/antibodies-to-pcpa-and-phtd-protect-mice-against-streptococcus-pneumoniae-by-a-macrophage-and-complement-dependent-mechanism
#6
Lucian Visan, Nicolas Rouleau, Emilie Proust, Loïc Peyrot, Arnaud Donadieu, Martina Ochs
Currently marketed Streptococcus pneumoniae (Spn) vaccines, which contain polysaccharide capsular antigens from the most common Spn serotypes, have substantially reduced pneumococcal disease rates but have limited coverage. A trivalent pneumococcal protein vaccine containing pneumococcal choline-binding protein A (PcpA), pneumococcal histidine triad protein D (PhtD), and detoxified pneumolysin is being developed to provide broader, cross-serotype protection. Antibodies against detoxified pneumolysin protect against bacterial pneumonia by neutralizing Spn-produced pneumolysin, but how anti-PhtD and anti-PcpA antibodies protect against Spn has not been established...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29134203/use-of-multiplex-quantitative-pcr-to-evaluate-the-impact-of-pneumococcal-conjugate-vaccine-on-nasopharyngeal-pneumococcal-colonization-in-african-children
#7
Courtney P Olwagen, Peter V Adrian, Marta C Nunes, Michelle J Groome, Mark F Cotton, Avy Violari, Shabir A Madhi
Pneumococcal conjugate vaccine (PCV) immunization of children induces shifts in colonizing pneumococcal serotypes. This study evaluated the effect of infant vaccination with 7-valent PCV (PCV7) on vaccine serotype (VT) colonization and whether the increase in nonvaccine serotype (NVT) was due to either unmasking of previously low-density-colonizing serotypes or increase in acquisition of NVT. A multiplex quantitative PCR (qPCR) was used to evaluate VT and NVT nasopharyngeal colonization in archived swabs of PCV-vaccinated and PCV-unvaccinated African children at 9 and 15 to 16 months of age...
November 2017: MSphere
https://www.readbyqxmd.com/read/29132991/attitudes-about-adult-vaccines-and-reminder-recall-in-a-safety-net-population
#8
Karen Albright, Laura P Hurley, Steven Lockhart, Dennis Gurfinkel, Brenda Beaty, L Miriam Dickinson, Anne Libby, Allison Kempe
Little is known about adult patients' attitudes toward vaccination and preferences for reminder/recall. The objective of this study was to determine patient perspectives on adult vaccines generally; attitudes about Tdap, pneumococcal polysaccharide (PPSV-23), and seasonal influenza vaccines specifically; and preferences for adult reminder/recall delivery. Twelve focus groups were conducted with 68 patients in a safety net health system. The sample was stratified by preferred language (English or Spanish), age (18-64 or 65+), and health status (with or without chronic conditions)...
November 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29132990/beneficiary-characteristics-and-vaccinations-in-the-end-stage-renal-disease-medicare-beneficiary-population-an-analysis-of-claims-data-2006-2015
#9
Angela K Shen, Jeffrey A Kelman, Rob Warnock, Weiwei Zhang, Stephaeno Brereton, Stephen McKean, Michael Wernecke, Steve Chu, Bruce G Gellin
BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) routinely recommends three vaccines - influenza, hepatitis B, and pneumococcal vaccines - for End-Stage Renal Disease (ESRD) dialysis patients. METHODS: We sought to assess vaccination coverage among fee-for-service (FFS) Medicare beneficiaries with ESRD who received Part B dialysis services at any point from January 1, 2006 through December 31, 2015 (through June 30, 2016 for influenza). To assess influenza vaccination rates in a given influenza season, we restricted the population to beneficiaries who were continuously enrolled in Medicare Parts A and B throughout all twelve months of that season...
November 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29132988/safety-and-immunogenicity-of-a-novel-multiple-antigen-pneumococcal-vaccine-in-adults-a-phase-1-randomised-clinical-trial
#10
Claire Entwisle, Sue Hill, Yin Pang, Michael Joachim, Ann McIlgorm, Camilo Colaco, David Goldblatt, Polly De Gorguette D'Argoeuves, Chris Bailey
BACKGROUND: Pneumococcal vaccines, combining multiple protein antigens, provide an alternative approach to currently marketed vaccines and may provide broader protection against pneumococcal disease. This trial evaluated the safety and immunogenicity of a novel vaccine candidate PnuBioVax in healthy young adults. METHODS: In a Phase 1 double-blind study, 36 subjects (18-40 years) were randomised to receive 3 doses of PnuBioVax, 28 days apart, at one of three dose levels (50, 200, 500 µg) or placebo...
November 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29131872/genetic-diversity-of-pneumococcal-surface-protein-a-in-invasive-pneumococcal-isolates-from-korean-children-1991-2016
#11
Ki Wook Yun, Eun Hwa Choi, Hoan Jong Lee
Pneumococcal surface protein A (PspA) is an important virulence factor of pneumococci and has been investigated as a primary component of a capsular serotype-independent pneumococcal vaccine. Thus, we sought to determine the genetic diversity of PspA to explore its potential as a vaccine candidate. Among the 190 invasive pneumococcal isolates collected from Korean children between 1991 and 2016, two (1.1%) isolates were found to have no pspA by multiple polymerase chain reactions. The full length pspA genes from 185 pneumococcal isolates were sequenced...
2017: PloS One
https://www.readbyqxmd.com/read/29130395/pneumococcal-whole-cell-and-protein-based-vaccines-changing-the-paradigm
#12
Michael E Pichichero
Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are many new emerging serotypes expressed by pneumococci. Areas covered: Mechanisms of protection by next-generation whole-cell vaccine (WCV) and/or multi-component pneumococcal purified protein vaccines (PPVs) in development for prevention of pneumococcal infections...
December 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29129213/vaccinations-in-older-adults
#13
REVIEW
Megan Burke, Theresa Rowe
Vaccines are important for preventing infections in adults aged ≥65 years. Older adults are at increased risk for complications from vaccine-preventable illnesses due to age-associated changes in immune function and chronic medical comorbidities. Vaccination rates for older adults remain low despite widely accepted practice guidelines. Recommended vaccinations for older adults include (1) influenza; (2) pneumococcal; (3) herpes zoster; (4) tetanus, diphtheria, pertussis; and (5) hepatitis B. Cost influences vaccination rates in older adults...
February 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29129177/copd-x-australian-and-new-zealand-guidelines-for-the-diagnosis-and-management-of-chronic-obstructive-pulmonary-disease-2017-update
#14
Ian A Yang, Juliet L Brown, Johnson George, Sue Jenkins, Christine F McDonald, Vanessa M McDonald, Kirsten Phillips, Brian J Smith, Nicholas A Zwar, Eli Dabscheck
Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and chronic airflow limitation, and is associated with exacerbations and comorbidities. Advances in the management of COPD are updated quarterly in the national COPD guidelines, the COPD-X plan, published by Lung Foundation Australia in conjunction with the Thoracic Society of Australia and New Zealand and available at http://copdx.org.au. Main recommendations: Spirometry detects persistent airflow limitation (post-bronchodilator FEV1/FVC < 0...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29126217/change-in-pneumococcus-serotypes-but-not-mortality-or-morbidity-in-pre-and-post-13-valent-polysaccharide-conjugate-vaccine-era-epidemiology-in-a-pediatric-intensive-care-unit-over-10-years
#15
Kam Lun Hon, King Hang Chan, Pak Long Ko, Michelle Ho Yan Cheung, Kathy Yin C Tsang, Lawrence C N Chan, Renee W Y Chan, Ting Fan Leung, Margaret Ip
Aim: Pneumococcus is a common commensal and an important pathogen among children for which immunization is available. Some serotypes occasionally cause severe pneumococcal disease with high mortality and morbidity. We reviewed all pneumococcal serotypes and mortality/morbidity in a pediatric intensive care unit (PICU) following universal pneumococcal conjugate vaccine (PCV) immunization. Methods: A 13-valent PCV was introduced in the universal immunization program in late 2011 in Hong Kong...
November 6, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29125809/burden-of-hospitalized-childhood-community-acquired-pneumonia-a-retrospective-cross-sectional-study-in-vietnam-malaysia-indonesia-and-the-republic-of-korea
#16
Kah Kee Tan, Duc Anh Dang, Ki Hwan Kim, Cissy Kartasasmita, Hwang Min Kim, Xu-Hao Zhang, Fakrudeen Shafi, Ta-Wen Yu, Emilio Ledesma, Nadia Meyer
BACKGROUND: Few studies describe the community-acquired pneumonia (CAP) burden in children in Asia. We estimated the proportion of all CAP hospitalizations in children from nine hospitals across the Republic of Korea (high-income), Indonesia, Malaysia (middle-income), and Vietnam (low/middle-income). METHODS: Over a one or two-year period, children <5 years hospitalized with CAP were identified using ICD-10 discharge codes. Cases were matched to standardized definitions of suspected (S-CAP), confirmed (C-CAP), or bacterial CAP (B-CAP) used in a pneumococcal conjugate vaccine efficacy study (COMPAS)...
November 10, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29120946/early-onset-neonatal-pneumococcal-sepsis-a-fatal-case-report-and-brief-literature-review
#17
Daniel Jrovsky, Ivan Cese Marchetti, Mariana Alves da Silva Mori, Ricardo Magalhães de Souza, Flávia Jacqueline Almeida, Marco Aurélio Palazzi Sáfadi, Eitan Naaman Berezin
Sepsis caused by Streptococcus pneumoniae is rare in neonates, although associated with high morbidity and mortality. We report a fatal case of invasive pneumococcal disease (NIPD) in a term neonate whose mother was healthy and did not receive any pneumococcal vaccine. Investigation of the infection source yielded negative results. Acquisition of infection through the birth canal was considered unlikely.
November 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29119074/case-report-on-a-defective-antibody-response-against-pneumococcal-serotype-9v-in-a-patient-with-a-single-episode-of-pneumonia
#18
Diana van Kessel, Thijs Hoffman, Heleen van Velzen-Blad, Bob Meek, Suzan van Mens, Jan Grutters, Ger Rijkers
Background: Patients with recurrent respiratory tract infections and an impaired response to pneumococcal polysaccharide vaccination are diagnosed with a specific antibody deficiency. In adult patients with pneumococcal pneumonia an impaired antibody response to the infecting pneumococcal serotype can sometimes be found. It is unknown whether these patients are unable to produce an adequate anti-polysaccharide antibody response to pneumococcal vaccination after recovery. Case presentation: The authors describe a case of invasive pneumonia caused by Streptococcus pneumoniae serotype 9V in a previously healthy 35-year-old female...
2017: Pneumonia
https://www.readbyqxmd.com/read/29118167/invasive-disease-caused-simultaneously-by-dual-serotypes-of-streptococcus-pneumoniae
#19
Kedibone Ndlangisa, Mignon du Plessis, Mushal Allam, Nicole Wolter, Linda de Gouveia, Keith P Klugman, Cheryl Cohen, Rebecca A Gladstone, Anne von Gottberg
There are at least 98 known pneumococcal serotypes. Invasive pneumococcal (IPD) disease is usually caused by a single serotype, and dual serotype IPD is rare. To assess factors associated with dual serotype IPD, patient information obtained through laboratory-based surveillance for IPD from 2005 through 2014 in South Africa was reviewed. Genomes of isolate pairs from co-infected individuals were sequenced to determine their molecular characteristics. For 30 (91%) of 33 patients with dual serotypes, one or both isolates were a pneumococcal conjugate vaccine (PCV13) serotype...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29116597/response-to-tetanus-and-pneumococcal-vaccination-following-administration-of-ixekizumab-in-healthy-participants
#20
Elisa V Gomez, Jessie L Bishop, Kimberley Jackson, Talia M Muram, Diane Phillips
BACKGROUND: Ixekizumab (IXE) is an interleukin (IL)-17A antagonist approved for the treatment of adults with moderate-to-severe psoriasis. OBJECTIVE: The objective of this study was to determine if the immune response to tetanus and pneumococcal vaccines in healthy subjects administered IXE was noninferior to control. METHODS: In a randomized, open-label, parallel-group study, adult subjects received vaccinations alone (N = 42, control) or in combination with 160 mg IXE subcutaneously 2 weeks prior to vaccination and 80 mg IXE on the day of vaccination (N = 41, IXE)...
November 7, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
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