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Prenatal alcohol exposure

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https://www.readbyqxmd.com/read/28645698/radiological-studies-of-fetal-alcohol-spectrum-disorders-in-humans-and-animal-models-an-updated-comprehensive-review
#1
Van T Nguyen, Suyinn Chong, Quang M Tieng, Karine Mardon, Graham J Galloway, Nyoman D Kurniawan
Fetal Alcohol Spectrum Disorders encompass a wide range of birth defects in children born to mothers who consumed alcohol during pregnancy. Typical mental impairments in FASD include difficulties in life adaptation and learning and memory, deficits in attention, visuospatial skills, language and speech disabilities, mood disorders and motor disabilities. Multimodal imaging methods have enabled in vivo studies of the teratogenic effects of alcohol on the central nervous system, giving more insight into the FASD phenotype...
June 20, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28636875/effects-of-prenatal-binge-like-ethanol-exposure-and-maternal-stress-on-postnatal-morphological-development-of-hippocampal-neurons-in-rats
#2
Ewa Jakubowska-Dogru, Birsen Elibol, Ilknur Dursun, Sinan Yürüker
BACKGROUND: Alcohol is one of the most commonly used drugs of abuse negatively affecting human health and it is known as a potent teratogen responsible for fetal alcohol syndrome (FAS), which is characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Searching for the potential morphological correlates of these effects, in this study, we compared the course of developmental changes in the morphology of principal hippocampal neurons in fetal-alcohol (A group), intubated control (IC group), and intact control male rats (C group) over a protracted period of the first two postnatal months...
June 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28634776/evidence-supporting-the-internal-validity-of-the-proposed-nd-pae-disorder
#3
Julie A Kable, Claire D Coles
The internal validity of the proposed Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) was evaluated in children diagnosed with either Fetal Alcohol Syndrome (FAS) or partial FAS who were 3-10 years of age and had enrolled in a math intervention study. Symptoms were coded as present or absent using assessments conducted in the study, including standardized measures of neurocognitive and behavioral functioning, parent interview, and direct observations of the child. The number of endorsed ND-PAE symptoms was not related to environmental factors but was moderately related to the child's age...
June 20, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28632983/a-descriptive-study-of-a-community-based-home-visiting-program-with-preschool-children-prenatally-exposed-to-alcohol
#4
Ana Hanlon-Dearman, Sayma Malik, Julia Wellwood, Karen Johnston, Holly Gammon, Kathy N Andrew, Breann Maxwell, Sally Longstaffe
BACKGROUND: Research suggests that prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorder (FASD) increases the risk of insecure caregiver-child attachment and related negative child emotional-behavioural outcomes. Research also shows positive effects of attachment-focused interventions in preventing disrupted caregiver-child attachment relationships; however, such interventions have not been specifically adapted for children with FASD. OBJECTIVES: This paper describes the implementation, challenges, and results of a community home-based attachment intervention, Circle of Security® (COS), with preschool children affected by PAE/FASD in Manitoba, Canada...
June 14, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28624747/who-is-most-affected-by-prenatal-alcohol-exposure-boys-or-girls
#5
Philip A May, Barbara Tabachnick, Julie M Hasken, Anna-Susan Marais, Marlene M de Vries, Ronel Barnard, Belinda Joubert, Marise Cloete, Isobel Botha, Wendy O Kalberg, David Buckley, Zachary R Burroughs, Heidre Bezuidenhout, Luther K Robinson, Melanie A Manning, Colleen M Adnams, Soraya Seedat, Charles D H Parry, H Eugene Hoyme
OBJECTIVE: To examine outcomes among boys and girls that are associated with prenatal alcohol exposure. METHODS: Boys and girls with fetal alcohol spectrum disorders (FASD) and randomly-selected controls were compared on a variety of physical and neurobehavioral traits. RESULTS: Sex ratios indicated that heavy maternal binge drinking may have significantly diminished viability to birth and survival of boys postpartum more than girls by age seven...
June 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28609804/psychometric-properties-of-brief-screening-tests-for-alcohol-use-disorders-during-pregnancy-in-argentina
#6
Mariana Beatriz López, Aldana Lichtenberger, Karina Conde, Mariana Cremonte
Background Considering the physical, mental and behavioral problems related to fetal alcohol exposure, prenatal clinical guides suggest a brief evaluation of alcohol consumption during pregnancy to detect alcohol intake and to adjust interventions, if required. Even if any alcohol use should be considered risky during pregnancy, identifying women with alcohol use disorders is important because they could need a more specific intervention than simple advice to abstain. Most screening tests have been developed and validated in male populations and focused on the long-term consequences of heavy alcohol use, so they might be inappropriate to assess consumption in pregnant women...
June 13, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28609669/sex-differences-in-associations-between-white-matter-microstructure-and-gonadal-hormones-in-children-and-adolescents-with-prenatal-alcohol-exposure
#7
K A Uban, M M Herting, J R Wozniak, E R Sowell
Despite accumulating evidence from animal models demonstrating that prenatal alcohol exposure (PAE) results in life-long neuroendocrine dysregulation, very little is known on this topic among humans with fetal alcohol spectrum disorders (FASD). We expected that alterations in gonadal hormones might interfere with the typical development of white matter (WM) myelination, and in a sex-dependent manner, in human adolescents with FASD. In order to investigate this hypothesis, we used diffusion tensor imaging (DTI) to assess: 1) whether or not sex moderates the impact of PAE on WM microstructure; and 2) how gonadal hormones relate to alterations in WM microstructure in children and adolescents affected by PAE...
May 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28608920/facial-curvature-detects-and-explicates-ethnic-differences-in-effects-of-prenatal-alcohol-exposure
#8
Michael Suttie, Leah Wetherill, Sandra W Jacobson, Joseph L Jacobson, H Eugene Hoyme, Elizabeth R Sowell, Claire Coles, Jeffrey R Wozniak, Edward P Riley, Kenneth L Jones, Tatiana Foroud, Peter Hammond
BACKGROUND: Our objective is to help clinicians detect the facial effects of prenatal alcohol exposure (PAE) by developing computer based tools for screening facial form. METHODS: All 415 individuals considered were evaluated by expert dysmorphologists and categorized as 1) healthy control (HC), 2) fetal alcohol syndrome (FAS) or 3) heavily prenatally alcohol exposed (HE) but not clinically diagnosable as FAS. 3D facial photographs were used to build models of facial form to support discrimination studies...
June 13, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28587682/plgf-a-placental-marker-of-fetal-brain-defects-after-in-utero-alcohol-exposure
#9
Matthieu Lecuyer, Annie Laquerrière, Soumeya Bekri, Céline Lesueur, Yasmina Ramdani, Sylvie Jégou, Arnaud Uguen, Pascale Marcorelles, Stéphane Marret, Bruno J Gonzalez
Most children with in utero alcohol exposure do not exhibit all features of fetal alcohol syndrome (FAS), and a challenge for clinicians is to make an early diagnosis of fetal alcohol spectrum disorders (FASD) to avoid lost opportunities for care. In brain, correct neurodevelopment requires proper angiogenesis. Since alcohol alters brain angiogenesis and the placenta is a major source of angiogenic factors, we hypothesized that it is involved in alcohol-induced brain vascular defects. In mouse, using in vivo repression and overexpression of PLGF, we investigated the contribution of placenta on fetal brain angiogenesis...
June 6, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28586867/prenatal-alcohol-exposure-no-safe-amount
#10
Megan A Moreno
No abstract text is available yet for this article.
June 5, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28586842/association-between-prenatal-alcohol-exposure-and-craniofacial-shape-of-children-at-12-months-of-age
#11
Evelyne Muggli, Harold Matthews, Anthony Penington, Peter Claes, Colleen O'Leary, Della Forster, Susan Donath, Peter J Anderson, Sharon Lewis, Cate Nagle, Jeffrey M Craig, Susan M White, Elizabeth J Elliott, Jane Halliday
Importance: Children who receive a diagnosis of fetal alcohol spectrum disorder may have a characteristic facial appearance in addition to neurodevelopmental impairment. It is not well understood whether there is a gradient of facial characteristics of children who did not receive a diagnosis of fetal alcohol spectrum disorder but who were exposed to a range of common drinking patterns during pregnancy. Objective: To examine the association between dose, frequency, and timing of prenatal alcohol exposure and craniofacial phenotype in 12-month-old children...
June 5, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28580296/cortical-gyrification-is-abnormal-in-children-with-prenatal-alcohol-exposure
#12
Timothy J Hendrickson, Bryon A Mueller, Elizabeth R Sowell, Sarah N Mattson, Claire D Coles, Julie A Kable, Kenneth L Jones, Christopher J Boys, Kelvin O Lim, Edward P Riley, Jeffrey R Wozniak
OBJECTIVES: Prenatal alcohol exposure (PAE) adversely affects early brain development. Previous studies have shown a wide range of structural and functional abnormalities in children and adolescents with PAE. The current study adds to the existing literature specifically on cortical development by examining cortical gyrification in a large sample of children with PAE compared to controls. Relationships between cortical development and intellectual functioning are also examined. EXPERIMENTAL DESIGN: Included were 92 children with PAE and 83 controls ages 9-16 from four sites in the Collaborative Initiative on FASD (CIFASD)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28578176/research-standardization-tools-pregnancy-measures-in-the-phenx-toolkit
#13
Ann Kinga Malinowski, Cande V Ananth, Patrick Catalano, Erin P Hines, Russell S Kirby, Mark A Klebanoff, John J Mulvihill, Hyagriv Simhan, Carol M Hamilton, Tabitha P Hendershot, Michael J Phillips, Lisa A Kilpatrick, Deborah R Maiese, Erin M Ramos, Rosalind J Wright, Siobhan M Dolan
Only through concerted and well-executed research endeavors can we gain the requisite knowledge to advance pregnancy care and have a positive impact on maternal and newborn health. Yet the heterogeneity inherent in individual studies limits our ability to compare and synthesize study results, thus impeding the capacity to draw meaningful conclusions that can be trusted to inform clinical care. The PhenX Toolkit (http://www.phenxtoolkit.org), supported since 2007 by the National Institutes of Health, is a web-based catalog of standardized protocols for measuring phenotypes and exposures relevant for clinical research...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28567436/-no-alcohol-is-recommended-but-health-care-students-attitudes-about-alcohol-consumption-during-pregnancy
#14
Kelly D Coons, Shelley L Watson, Nicole M Yantzi, Nancy E Lightfoot, Sylvie Larocque
Canadian findings suggest that health care providers require further training and education to support their work preventing fetal alcohol spectrum disorder (FASD). However, the knowledge and training of health care students in relation to FASD remains largely unexplored. The purpose of this study was to understand the attitudes and beliefs of health care students about alcohol use during pregnancy. Twenty-one health care students participated in a scenario-based vignette about alcohol consumption during pregnancy...
January 2017: Global Qualitative Nursing Research
https://www.readbyqxmd.com/read/28560153/sexual-dimorphism-of-volume-reduction-but-not-cognitive-deficit-in-fetal-alcohol-spectrum-disorders-a-combined-diffusion-tensor-imaging-cortical-thickness-and-brain-volume-study
#15
Sarah Treit, Zhang Chen, Dongming Zhou, Lauren Baugh, Carmen Rasmussen, Gail Andrew, Jacqueline Pei, Christian Beaulieu
Quantitative magnetic resonance imaging (MRI) has revealed abnormalities in brain volumes, cortical thickness and white matter microstructure in fetal alcohol spectrum disorders (FASD); however, no study has reported all three measures within the same cohort to assess the relative magnitude of deficits, and few studies have examined sex differences. Participants with FASD (n = 70; 30 females; 5-32 years) and healthy controls (n = 74; 35 females; 5-32 years) underwent cognitive testing and MRI to assess cortical thickness, regional brain volumes and fractional anisotropy (FA)/mean diffusivity (MD) of white matter tracts...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28554529/maternal-alcohol-exposure-during-mid-pregnancy-dilates-fetal-cerebral-arteries-via-endocannabinoid-receptors
#16
Olga Seleverstov, Ana Tobiasz, J Scott Jackson, Ryan Sullivan, Dejian Ma, J Pierce Sullivan, Steven Davison, Yada Akkhawattanangkul, Danielle L Tate, Terry Costello, Stacey Barnett, Wei Li, Giancarlo Mari, Alex M Dopico, Anna N Bukiya
Prenatal alcohol exposure often results in fetal alcohol syndrome and fetal alcohol spectrum disorders. Mechanisms of fetal brain damage by alcohol remain unclear. We used baboons (Papio spp.) to study alcohol-driven changes in the fetal cerebral artery endocannabinoid system. Pregnant baboons were subjected to binge alcohol exposure via gastric infusion three times during a period equivalent to the second trimester of human pregnancy. A control group was infused with orange-flavored drink that was isocaloric to the alcohol-containing solution...
June 2017: Alcohol
https://www.readbyqxmd.com/read/28552459/prenatal-alcohol-exposure-and-traumatic-childhood-experiences-a-systematic-review
#17
REVIEW
Alan Price, Penny A Cook, Sarah Norgate, Raja Mukherjee
Prenatal alcohol exposure (PAE) and traumatic childhood experiences (trauma) such as abuse or neglect can each cause central nervous system neurobiological changes or structural damage which can manifest as cognitive and behavioural dysfunction. In cases where both exposures have occurred, the risk of neurodevelopmental impairment may be greater, but this interaction has not been well studied. Here we present a systematic review that identified five primary research studies which investigated either the impact of trauma in children with PAE, or of PAE in children with trauma...
May 25, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28544995/intrauterine-exposure-to-tobacco-and-executive-functioning-in-high-school
#18
Ruth Rose-Jacobs, Mark A Richardson, Kathryn Buchanan-Howland, Clara A Chen, Howard Cabral, Timothy C Heeren, Jane Liebschutz, Leah Forman, Deborah A Frank
BACKGROUND: Executive functioning (EF), an umbrella construct encompassing gradual maturation of cognitive organization/management processes, is important to success in multiple settings including high school. Intrauterine tobacco exposure (IUTE) correlates with negative cognitive/behavioral outcomes, but little is known about its association with adolescent EF and information from real-life contexts is sparse. We evaluated the impact of IUTE on teacher-reported observations of EF in urban high school students controlling for covariates including other intrauterine and adolescent substance exposures...
July 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28536981/a-retrospective-cohort-study-of-birth-outcomes-in-neonates-exposed-to-naltrexone-in-utero-a-comparison-with-methadone-buprenorphine-and-non-opioid-exposed-neonates
#19
Erin Kelty, Gary Hulse
BACKGROUND: Naltrexone may provide a suitable alternative to methadone and buprenorphine in the treatment of pregnant opioid-dependent women; however, little is known about its effects on neonatal morbidity and mortality. OBJECTIVE: The aim was to evaluate the health of neonates exposed to naltrexone in utero, and compare it with outcomes in neonates exposed to methadone or buprenorphine and a non-exposed control group. METHODS: Sequential cohorts of Western Australian (WA) opioid-dependent women treated with implant naltrexone, oral methadone or sublingual buprenorphine were identified via records from a drug and alcohol clinic (Subiaco, WA) for naltrexone and state prescribing records for methadone and buprenorphine...
May 23, 2017: Drugs
https://www.readbyqxmd.com/read/28523385/attention-deficit-hyperactivity-disorder-adhd-symptoms-in-children-adopted-from-poland-and-their-atypical-association-patterns-a-bayesian-approach
#20
Donna A de Maat, Sandra Knuiman, Catharina H A M Rijk, René A C Hoksbergen, Anneloes L van Baar
Although high rates of attention-deficit hyperactivity disorder (ADHD) symptoms have been observed among internationally adopted children, research on these symptoms in Polish adoptees is lacking. Therefore, we examined ADHD symptoms in Polish adoptees and their relationship to pre-adoptive risk factors, that is, time in institutional care, early deprivation, and prenatal alcohol exposure. We further compared the association patterns and gender distribution of ADHD symptoms in children adopted from Poland to those reported in the literature for ADHD symptoms in non-adopted children...
May 18, 2017: Journal of Abnormal Child Psychology
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