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Fetal alcohol spectrum disorders

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https://www.readbyqxmd.com/read/29775869/mathematics-intervention-for-children-with-fetal-alcohol-spectrum-disorder-a-replication-and-extension-of-the-math-interactive-learning-experience-mile-program
#1
Katrina Kully-Martens, Jacqueline Pei, Julie Kable, Claire D Coles, Gail Andrew, Carmen Rasmussen
BACKGROUND: Individuals with fetal alcohol spectrum disorders (FASD) experience deficits in behavior, cognition, and academic functioning resulting from prenatal alcohol exposure (PAE). Although receiving intervention for developmental disabilities is a strong protective factor against negative outcomes in FASD, intervention research in this population is in its infancy. AIMS: The purpose of this study was to replicate and extend a mathematics intervention, the Math Interactive Learning Experience (MILE) program, which was developed in the USA specifically for children with FASD...
May 15, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29764710/a-systematic-review-to-explore-the-feasibility-of-a-behavioural-sleep-intervention-for-insomnia-in-children-with-neurodevelopmental-disorders-a-transdiagnostic-approach
#2
REVIEW
Gabrielle Rigney, Nicole S Ali, Penny V Corkum, Cary A Brown, Evelyn Constantin, Roger Godbout, Ana Hanlon-Dearman, Osman Ipsiroglu, Graham J Reid, Sarah Shea, Isabel M Smith, Hendrik F M Van der Loos, Shelly K Weiss
Children with neurodevelopmental disorders (NDD) are at high risk for sleep problems, especially insomnia. It is currently not known whether behavioural sleep interventions developed for typically developing (TD) children are effective for children with NDD, and if interventions need to be modified for each diagnostic group. The aim of this systematic review was to identify and evaluate commonalities, trends in outcomes, and the methodological quality of parent-delivered behavioural sleep interventions for children with NDD, specifically Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Cerebral Palsy, and Fetal Alcohol Spectrum Disorder...
March 31, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29753864/long-term-reductions-in-the-population-of-gabaergic-interneurons-in-the-mouse-hippocampus-following-developmental-ethanol-exposure
#3
Clark W Bird, Devin H Taylor, Natalie J Pinkowski, G Jill Chavez, C Fernando Valenzuela
Developmental exposure to ethanol leads to a constellation of cognitive and behavioral abnormalities known as Fetal Alcohol Spectrum Disorders (FASDs). Many cell types throughout the central nervous system are negatively impacted by gestational alcohol exposure, including inhibitory, GABAergic interneurons. Little evidence exists, however, describing the long-term impact of fetal alcohol exposure on survival of interneurons within the hippocampal formation, which is critical for learning and memory processes that are impaired in individuals with FASDs...
May 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29741798/a-pilot-rct-of-an-internet-intervention-to-reduce-the-risk-of-alcohol-exposed-pregnancy
#4
Karen Ingersoll, Christina Frederick, Kirsten MacDonnell, Lee Ritterband, Holly Lord, Brogan Jones, Lauren Truwit
BACKGROUND: Preventing alcohol-exposed pregnancies (AEPs) could reduce the incidence of fetal alcohol spectrum disorders. Previous face-to-face interventions significantly reduced risk for AEP, but a scalable intervention is needed to reach more women at risk. METHODS: This study compared a 6 Core automated, interactive, and tailored Internet intervention, the Contraception and Alcohol Risk Reduction Internet Intervention (CARRII), to a static patient education (PE) website for its effect on AEP risk...
May 9, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29738852/altered-maternal-immune-networks-are-associated-with-adverse-child-neurodevelopment-impact-of-alcohol-consumption-during-pregnancy
#5
Tamara S Bodnar, Charlis Raineki, Wladimir Wertelecki, Lyubov Yevtushok, Larisa Plotka, Natalya Zymak-Zakutnya, Gordon Honerkamp-Smith, Alan Wells, Matthieu Rolland, Todd S Woodward, Claire D Coles, Julie A Kable, Christina D Chambers, Joanne Weinberg
Cytokines and chemokines are potent modulators of brain development and as such, dysregulation of the maternal immune system can result in deviations in the fetal cytokine balance, altering the course of typical brain development, and putting the individual on a "pathway to pathology". In the current study, we used a multi-variate approach to evaluate networks of interacting cytokines and investigated whether alterations in the maternal immune milieu could be linked to alcohol-related and alcohol-independent child neurodevelopmental delay...
May 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29724514/neurocognitive-functioning-in-young-offenders-with-fetal-alcohol-spectrum-disorder
#6
Katherine Flannigan, Jacqueline Pei, Andrew Burke, Roy Frenzel, Carmen Rasmussen
No abstract text is available yet for this article.
April 30, 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29703853/a-modified-delphi-study-towards-developing-a-guideline-to-inform-policy-on-fetal-alcohol-spectrum-disorders-in-south-africa-a-study-protocol
#7
Babatope O Adebiyi, Ferdinand C Mukumbang, Kufre J Okop, Anna-Marie Beytell
INTRODUCTION: Maternal alcohol consumption during pregnancy can result in mental and physical birth defects in individuals. These birth defects are usually described as fetal alcohol spectrum disorders (FASDs). With an estimated 183-259 per 1000 children born with FASDs, South Africa is identified to have the highest prevalence of FASDs in the world. Nevertheless, there is a lack of appropriate policies, guidelines and interventions addressing the issues around FASDs. This protocol outlines a proposed process for developing a guideline to inform policies on FASDs...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29691979/the-bdnf-val68met-polymorphism-modulates-how-developmental-ethanol-exposure-impacts-the-hippocampus
#8
Clark W Bird, Brian C Baculis, Jacob J Mayfield, Glenna J Chavez, Tiahna Ontiveros, Dana J Paine, Aaron J Marks, Alicia L Gonzales, Dorit Ron, C Fernando Valenzuela
Prenatal exposure to alcohol causes a wide range of deficits known as Fetal Alcohol Spectrum Disorders (FASDs). Many factors determine vulnerability to developmental alcohol exposure including timing and pattern of exposure, nutrition, and genetics. Here, we characterized how a prevalent single nucleotide polymorphism in the human brain-derived neurotrophic factor (BDNF) gene (val66met) modulates FASDs severity. This polymorphism disrupts BDNF's intracellular trafficking and activity dependent secretion, and has been linked to increased incidence of neuropsychiatric disorders such as depression and anxiety...
April 24, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29688328/ethanol-exposure-in-utero-disrupts-radial-migration-and-pyramidal-cell-development-in-the-somatosensory-cortex
#9
Laurie C Delatour, Pamela W Yeh, Hermes H Yeh
Deficits in sensory processing in Fetal Alcohol Spectrum Disorders (FASD) implicate dysfunction in the somatosensory cortex. However, the effects of prenatal ethanol exposure on the development of this region await elucidation. Here, we used an established mouse model of FASD with binge-type ethanol exposure from embryonic day 13.5-16.5 to investigate the effects of prenatal ethanol exposure on pyramidal neurons in the somatosensory cortex. Specifically, we focused on the radial migration of primordial pyramidal neurons during embryonic corticogenesis and their morphology and function during active synaptogenesis in early postnatal development...
April 24, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29679679/activation-of-cyclic-gmp-dependent-protein-kinase-blocks-alcohol-mediated-cell-death-and-calcium-disruption-in-cerebellar-granule-neurons
#10
Dimitrios E Kouzoukas, Ramesh C Bhalla, Nicholas J Pantazis
Alcohol during brain development leads to the widespread neuronal death observed in fetal alcohol spectrum disorders (FASD). In comparison, the mature brain is less vulnerable to alcohol. Studies into maturation-acquired alcohol resistance uncovered a protective mechanism that reduces alcohol-induced neuronal death through nitric oxide-cGMP-cyclic GMP-dependent protein kinase (NO-cGMP-cGK) signaling. However, the downstream processes underlying this neuroprotection remain unclear. Alcohol can disrupt levels of intracellular calcium ([Ca2+ ]i ) in vulnerable neuronal populations to trigger cell death in both in vivo and in vitro models of FASD...
April 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29672868/fetal-cerebral-circulation-as-target-of-maternal-alcohol-consumption
#11
Anna N Bukiya, Alex M Dopico
Alcohol (ethanol) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the US. The etiology of FAS/FASD remains poorly understood...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29658509/-experimental-approaches-to-the-investigation-of-behavioral-disorders-associated-with-prenatal-alcohol-exposure
#12
E V Razumkina, P K Anokhin, T V Proskuryakova, I Yu Shamakina
Fetal alcohol spectrum disorders (FASD) is an umbrella term which covers a wide range of deficits in prenatal and postnatal growth, anatomy and CNS functions produced by prenatal alcohol exposure. The most severe form of FASD is fetal alcohol syndrome (FAS) characterized by additional specific craniofacial and brain malformations. Despite a high prevalence and extensive clinical studies, the fundamental mechanisms of FASD are still poorly understood. Thereby, experimental models, which allow better control for both socio-environmental and genetic factors, are critical to our understanding of FASD...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29623043/developmental-ethanol-exposure-causes-reduced-feeding-and-reveals-a-critical-role-for-neuropeptide-f-in-survival
#13
Amanda Guevara, Hillary Gates, Brianna Urbina, Rachael French
Food intake is necessary for survival, and natural reward circuitry has evolved to help ensure that animals ingest sufficient food to maintain development, growth, and survival. Drugs of abuse, including alcohol, co-opt the natural reward circuitry in the brain, and this is a major factor in the reinforcement of drug behaviors leading to addiction. At the junction of these two aspects of reward are alterations in feeding behavior due to alcohol consumption. In particular, developmental alcohol exposure (DAE) results in a collection of physical and neurobehavioral disorders collectively referred to as Fetal Alcohol Spectrum Disorder (FASD)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29602689/benefits-of-caseload-midwifery-to-prevent-fetal-alcohol-spectrum-disorder-a-discussion-paper
#14
Natasha Reid, Jenny Gamble, Debra K Creedy, Amy Finlay-Jones
BACKGROUND: Exposure to alcohol prenatally can result in a child being diagnosed with fetal alcohol spectrum disorder. Affected infants experience lifelong impairments that can involve, physical, cognitive, behavioural and emotional difficulties that impact on their functional capacity. Effective prevention of fetal alcohol spectrum disorder is critically needed in Australia. Reduction in the prevalence of this disorder will only be possible if we prevent alcohol consumption during pregnancy...
March 27, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29582069/global-prevalence-of-fetal-alcohol-spectrum-disorder-in-italy-reply
#15
Shannon Lange, Jürgen Rehm, Svetlana Popova
No abstract text is available yet for this article.
March 26, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29582047/global-prevalence-of-fetal-alcohol-spectrum-disorder-in-italy
#16
Simona Pichini, Roberta Pacifici, Francesco Paolo Busardò
No abstract text is available yet for this article.
March 26, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29581212/study-protocol-for-a-self-controlled-cluster-randomised-trial-of-the-alert-program-to-improve-self-regulation-and-executive-function-in-australian-aboriginal-children-with-fetal-alcohol-spectrum-disorder
#17
Bree Wagner, James P Fitzpatrick, Trevor G Mazzucchelli, Martyn Symons, Heather Carmichael Olson, Tracy Jirikowic, Donna Cross, Edie Wright, Emma Adams, Maureen Carter, Kaashifah Bruce, Jane Latimer
INTRODUCTION: While research highlights the benefits of early diagnosis and intervention for children with fetal alcohol spectrum disorders (FASD), there are limited data documenting effective interventions for Australian children living in remote communities. METHODS AND ANALYSIS: This self-controlled cluster randomised trial is evaluating the effectiveness of an 8-week Alert Program school curriculum for improving self-regulation and executive function in children living in remote Australian Aboriginal communities...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29571046/the-contributions-of-dr-kathleen-k-sulik-to-fetal-alcohol-spectrum-disorders-research-and-prevention
#18
REVIEW
Scott E Parnell, Edward P Riley, Kenneth R Warren, Kathleen T Mitchell, Michael E Charness
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career...
June 2018: Alcohol
https://www.readbyqxmd.com/read/29569352/have-we-done-enough-for-people-with-fetal-alcohol-spectrum-disorders
#19
Ilona Autti-Rämö
No abstract text is available yet for this article.
March 22, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29555138/optimizing-an-ehealth-insomnia-intervention-for-children-with-neurodevelopmental-disorders-a-delphi-study
#20
Nicole Ali, Gabrielle Rigney, Shelly K Weiss, Cary A Brown, Evelyn Constantin, Roger Godbout, Ana Hanlon-Dearman, Osman Ipsiroglu, Graham J Reid, Sarah Shea, Isabel M Smith, Machiel Van der Loos, Penny V Corkum
Insomnia, which is related to daytime deficits and is a common problem for children with neurodevelopmental disorders (NDDs), is often successfully treated with behavioral strategies. However, there are barriers to accessing these treatments, and there has been little research examining what these interventions need to be usable and effective. The goal of this study was to gain consensus from experts in the field on the key components of an eHealth, parent-implemented, intervention program aimed at improving sleep in children with attention-deficit/hyperactivity disorder, autism spectrum disorder, cerebral palsy, and fetal alcohol spectrum disorder...
April 2018: Sleep Health
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