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https://www.readbyqxmd.com/read/28717523/assessment-of-emotional-expressions-after-full-face-transplantation
#1
Çağdaş Topçu, Hilmi Uysal, Ömer Özkan, Özlenen Özkan, Övünç Polat, Merve Bedeloğlu, Arzu Akgül, Ela Naz Döğer, Refik Sever, Nur Ebru Barçın, Kadriye Tombak, Ömer Halil Çolak
We assessed clinical features as well as sensory and motor recoveries in 3 full-face transplantation patients. A frequency analysis was performed on facial surface electromyography data collected during 6 basic emotional expressions and 4 primary facial movements. Motor progress was assessed using the wavelet packet method by comparison against the mean results obtained from 10 healthy subjects. Analyses were conducted on 1 patient at approximately 1 year after face transplantation and at 2 years after transplantation in the remaining 2 patients...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28711536/the-outcomes-of-primary-transsphenoidal-surgery-in-cushing-s-disease-experience-of-a-tertiary-center
#2
Fatma Ela Keskin, Hande Mefkure Ozkaya, Murat Bolayirli, Secil Erden, Pınar Kadioglu, Necmettin Tanriover, Nurperi Gazioglu
BACKGROUND: To report the initial and long-term remission rates and related factors, secondary treatments, and outcomes of a series of patients with Cushing's disease (CD). METHODS: One hundred forty-seven consecutive adult patients with CD who underwent primary trans-sphenoidal surgery between 1998 and 2014 were included in this study. Eighty-two were followed up in Cerrahpasa Medical Faculty Endocrinology and Metabolism outpatient clinic. The patients were requested to attend a long-term remission assessment; 55 could be contacted and data for the remaining 27 patients' last visit to the outpatient clinics were reviewed for early and late remission...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28699976/discordant-lipid-pattern-and-carotid-atherosclerotic-plaque-importance-of-remnant-cholesterol
#3
Walter Masson, Martín Lobo, Graciela Molinero, Daniel Siniawski
Background: Subjects with levels of non-HDL-C 30 mg/dL above those of LDL-C (lipid discordance) or with high remnant cholesterol levels could have a greater residual cardiovascular risk. Objectives: To determine the prevalence of lipid discordance in a primary prevention population and analyze the clinical variables associated with it; To investigate the association between lipid discordance and remnant cholesterol with the presence of carotid plaque. Methods: Primary prevention patients without diabetes or lipid-lowering therapy were included...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28685461/correlation-between-hypoxia-proteins-and-epr-detected-hypoxia-in-tumors
#4
Martyna Krzykawska-Serda, Richard C Miller, Martyna Elas, Boris Epel, Eugene D Barth, Mathew Maggio, Howard J Halpern
Rapid expansion of tumor cells that outpace existing vasculature essential for nutrient and oxygen support as well as waste removal, correlates with profound changes in the microenvironment including angiogenesis, vasodilation, glucose metabolism, and cell cycle perturbations. Since hypoxic cells are up to three times more radioresistant than normoxic cells, identification of hypoxic populations to predict radiotherapeutic outcome is important. The consequences of hypoxia and activated proteins contribute to radioresistant tumors and radiotherapeutic failure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28683237/late-night-salivary-cortisol-is-unaltered-in-patients-with-polycystic-ovarian-syndrome-pcos-irrespective-of-disease-phenotype-and-in-obese-women-irrespective-of-the-presence-of-pcos
#5
Hande Mefkure Ozkaya, Fatma Ela Keskin, Abdullah Tuten, Ebru Korkmaz, Hulya Zeynep Oktay, Pinar Kadioglu
OBJECTIVE: To determine cut-off values of late-night salivary cortisol (LNSC) using an electrochemiluminescent immunoassay (ECLIA) and to investigate whether the diagnostic performance of the assay was influenced by the presence of obesity or polycystic ovary syndrome (PCOS). METHODS: A total of 124 subjects comprising 25 patients with Cushing's syndrome (CS), 44 with PCOS (22 nonobese and 22 obese), 21 with constitutional obesity (CO), and 34 healthy subjects (HS) were included in the study...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28678931/vascular-aging-and-arterial-stiffness
#6
Luana de Rezende Mikael, Anelise Machado Gomes de Paiva, Marco Mota Gomes, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim, Priscila Valverde de Oliveira Vitorino, Maicon Borges Euzébio, Wátila de Moura Sousa, Weimar Kunz Sebba Barroso
Cardiovascular diseases (CVD) account annually for almost one third of all deaths worldwide. Among the CVD, systemic arterial hypertension (SAH) is related to more than half of those outcomes. Type 2 diabetes mellitus is an independent risk factor for SAH because it causes functional and structural damage to the arterial wall, leading to stiffness. Several studies have related oxidative stress, production of free radicals, and neuroendocrine and genetic changes to the physiopathogenesis of vascular aging. Indirect ways to analyze that aging process have been widely studied, pulse wave velocity (PWV) being considered gold standard to assess arterial stiffness, because there is large epidemiological evidence of its predictive value for cardiovascular events, and it requires little technical knowledge to be performed...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28677712/curvature-variation-controls-particle-aggregation-on-fluid-vesicles
#7
Afshin Vahid, Anđela Šarić, Timon Idema
Cellular membranes exhibit a large variety of shapes, strongly coupled to their function. Many biological processes involve dynamic reshaping of membranes, usually mediated by proteins. This interaction works both ways: while proteins influence the membrane shape, the membrane shape affects the interactions between the proteins. To study these membrane-mediated interactions on closed and anisotropically curved membranes, we use colloids adhered to ellipsoidal membrane vesicles as a model system. We find that two particles on a closed system always attract each other, and tend to align with the direction of largest curvature...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28673102/open-reduction-assisted-with-an-external-fixator-and-internal-fixation-with-calcaneal-locking-plate-for-intra-articular-calcaneal-fractures
#8
Hui Yao, Huading Lu, Huiqing Zhao, Lulu Lv, Gang Hou
BACKGROUND: The extensile lateral approach (ELA) has been considered to be a standard approach for displaced intra-articular calcaneal fractures (DICF) because it provides excellent exposure and allows direct reduction of the depressed posterior facet fragment. But continuous retraction during surgery needs sufficient manpower and may cause ischemia. Failure of rigid fixation of DICF will not allow for early weight bearing and may lead to a loss of reduction. To avoid these disadvantages, this study presents open reduction assisted with an external fixator and internal fixation with a calcaneal locking plate...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28670191/verifying-sarcoidosis-activity-chitotriosidase-versus-ace-in-sarcoidosis-a-case-control-study
#9
Spasoje Popević, Zorica Šumarac, Dragana Jovanović, Dragan Babić, Mihailo Stjepanović, Snežana Jovičić, Dragana Šobić-Šaranović, Snežana Filipović, Branko Gvozdenović, Maja Omčikus, Anđela Milovanović, Jelica Videnović-Ivanov, Ana Radović, Vladimir Žugić, Violeta Mihailović-Vučinić
BACKGROUND: Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls. METHODS: Four hundred and thirty biopsy positive sarcoidosis patients were divided into groups with active and inactive disease, and groups with acute or chronic disease...
October 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28663440/elabela-deficiency-promotes-preeclampsia-and-cardiovascular-malformations-in-mice
#10
Lena Ho, Marie Van Dijk, Sam Tan Jian Chye, Daniel M Messerschmidt, Serene C Chng, Sheena Ong, Ling Ka Yi, Souad Boussata, Grace Hui-Yi Goh, Gijs B Afink, Chin Yan Lim, N Ray Dunn, Davor Solter, Barbara B Knowles, Bruno Reversade
Pre-eclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. While PE is the leading cause of fetal and maternal morbidity/mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin receptor (APLNR, or APJ), is a circulating hormone secreted by the placenta. Elabela but not Apelin knockout pregnant mice exhibit PE-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis...
June 29, 2017: Science
https://www.readbyqxmd.com/read/28658342/robotic-transversus-abdominis-release-tar-is-it-possible-to-offer-minimally-invasive-surgery-for-abdominal-wall-complex-defects
#11
Maria Vitória França DO Amaral, José Ricardo Guimarães, Paula Volpe, Flávio Malcher Martins DE Oliveira, Carlos Eduardo Domene, Sérgio Roll, Leandro Totti Cavazzola
We describe the preliminary national experience and the early results of the use of robotic surgery to perform the posterior separation of abdominal wall components by the Transversus Abdominis Release (TAR) technique for the correction of complex defects of the abdominal wall. We performed the procedures between 04/2/2015 and 06/15/2015 and the follow-up time was up to six months, with a minimum of two months. The mean surgical time was five hours and 40 minutes. Two patients required laparoscopic re-intervention, since one developed hernia by peritoneal migration of the mesh and one had mesh extrusion...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28641778/clinical-presentations-metabolic-abnormalities-and-end-organ-complications-in-patients-with-familial-partial-lipodystrophy
#12
Baris Akinci, Huseyin Onay, Tevfik Demir, Şenay Savas-Erdeve, Ramazan Gen, Ilgin Yildirim Simsir, Fatma Ela Keskin, Mehmet Sercan Erturk, Ayse Kubat Uzum, Guzin Fidan Yaylali, Nilufer Kutbay Ozdemir, Tahir Atik, Samim Ozen, Banu Sarer Yurekli, Tugce Apaydin, Canan Altay, Gulcin Akinci, Leyla Demir, Abdurrahman Comlekci, Mustafa Secil, Elif Arioglu Oral
OBJECTIVE: Familial partial lipodystrophy (FPLD) is a rare genetic disorder characterized by partial lack of subcutaneous fat. METHODS: This multicenter prospective observational study included data from 56 subjects with FPLD (18 independent Turkish families). Thirty healthy controls were enrolled for comparison. RESULTS: Pathogenic variants of the LMNA gene were determined in nine families. Of those, typical exon 8 codon 482 pathogenic variants were identified in four families...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28630408/the-cellular-and-circuit-basis-for-evolutionary-change-in-sensory-perception-in-mormyrid-fishes
#13
Alejandro Vélez, Tsunehiko Kohashi, Anan Lu, Bruce A Carlson
Species differences in perception have been linked to divergence in gross neuroanatomical features of sensory pathways. The anatomical and physiological basis of evolutionary change in sensory processing at cellular and circuit levels, however, is poorly understood. Here, we show how specific changes to a sensory microcircuit are associated with the evolution of a novel perceptual ability. In mormyrid fishes, the ability to detect variation in electric communication signals is correlated with an enlargement of the midbrain exterolateral nucleus (EL), and a differentiation into separate anterior (ELa) and posterior (ELp) regions...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28626546/o-blood-group-as-a-risk-factor-for-helicobacter-pylori-igg-seropositivity-among-pregnant-sudanese-women
#14
Gasim I Gasim, Abdelmageed Elmugabil, Hamdan Z Hamdan, Duria A Rayis, Ishag Adam
The objective was to investigate the prevalence and the association between blood groups and Helicobacter pylori IgG seropositivity among pregnant Sudanese women. A cross-sectional survey was carried-out at Saad Abul Ela Maternity Hospital, Khartoum, Sudan during the period of July 2014 through December 2015. Questionnaires covering socio-demographic and obstetrics information were administered. Specific H. pylori IgG antibody was analysed using ELISA. One hundred eighty six pregnant women were enrolled. The mean (SD) of the age, parity was 28...
June 7, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28624823/effect-of-interferon-%C3%AE-and-combined-interferon-%C3%AE-with-lamivudine-treatment-on-anthropometric-measurements-in-children-with-chronic-hepatitis-b
#15
Nafiye Urganci, Derya Kalyoncu, Ela Erdem Eralp
No abstract text is available yet for this article.
June 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28614430/effects-of-the-application-of-therapeutic-massage-in-children-with-cancer-a-systematic-review
#16
Juan Rodríguez-Mansilla, Blanca González-Sánchez, Silvia Torres-Piles, Jorge Guerrero Martín, María Jiménez-Palomares, Macarena Núñez Bellino
Objective: to learn about the effects of the use of therapeutic massage in children with cancer. Method: systematic review of controlled clinical trials The search was conducted in November 2014 in the following databases: Pubmed, CSIC, Dialnet, Scopus, Cochrane and PEDro. Inclusion criteria were: clinical trials, published in English or Spanish, analyzing the effects of massage on the different stages and types of childhood cancer (between 1 and 18 years old). Results: of 1007 articles found, 7 met the inclusion criteria...
June 8, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28595091/detection-and-characterisation-of-bone-destruction-in-murine-rheumatoid-arthritis-using-statistical-shape-models
#17
James M Brown, Ewan Ross, Guillaume Desanti, Atif Saghir, Andy Clark, Chris Buckley, Andrew Filer, Amy Naylor, Ela Claridge
Rheumatoid arthritis (RA) is an autoimmune disease in which chronic inflammation of the synovial joints can lead to destruction of cartilage and bone. Pre-clinical studies attempt to uncover the underlying causes by emulating the disease in genetically different mouse strains and characterising the nature and severity of bone shape changes as indicators of pathology. This paper presents a fully automated method for obtaining quantitative measurements of bone destruction from volumetric micro-CT images of a mouse hind paw...
May 23, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28591299/anxiety-and-coping-in-women-with-breast-cancer-in-chemotherapy
#18
Araceli Vicente da Silva, Eliana Zandonade, Maria Helena Costa Amorim
Objective: to identify the coping strategies used by women with breast cancer in chemotherapy and to verify the association with the anxiety profile presented by them. Method: cross-sectional study of the analytical type. We used a random sample of 307 women with cancer in previous chemotherapy, adjuvant or palliative treatment. The data was collected using an interview technique with form registration, active search in medical records, Scale of Mode of Confronting Problems and Inventory of Anxiety and State...
June 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28583915/elabela-and-an-elabela-fragment-protect-against-aki
#19
Hong Chen, Lin Wang, Wenjun Wang, Cheng Cheng, Yu Zhang, Yu Zhou, Congyi Wang, Xiaoping Miao, Jiao Wang, Chao Wang, Jianshuang Li, Ling Zheng, Kun Huang
Renal ischemia-reperfusion (I/R) injury is the most common cause of AKI, which associates with high mortality and has no effective therapy. ELABELA (ELA) is a newly identified 32-residue hormone peptide highly expressed in adult kidney. To investigate whether ELA has protective effects on renal I/R injury, we administered the mature peptide (ELA32) or the 11-residue furin-cleaved fragment (ELA11) to hypoxia-reperfusion (H/R)-injured or adriamycin-treated renal tubular cells in vitro ELA32 and ELA11 significantly inhibited the elevation of the DNA damage response, apoptosis, and inflammation in H/R-injured renal tubular cells and suppressed adriamycin-induced DNA damage response...
June 5, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28583486/ototoxicity-associated-with-topical-administration-of-diclofenac-sodium-as-an-otic-drop-an-experimental-animal-study
#20
Engin Acioglu, Ozgur Yigit, Firat Onur, Ahmet Atas, Ela Araz Server, Eyup Kara
OBJECTIVES: The aim of the study is to evaluate the ototoxicity of topical diclofenac sodium in comparison to positive and negative controls prior to the investigation of analgesic and anti-inflammatory efficacy of the agent in otic administration. METHODS: Twenty four ears of 12 guinea pigs were included in the study. Wide myringotomy was performed on all tympanic membranes under general anesthesia and auditory brainstem responses (ABR) were evaluated. The subjects were separated into four groups, two groups received diclofenac sodium at low and high doses, positive controls received gentamicin and negative controls received isotonic sodium chloride topically for 14 days and ABRs were reevaluated...
July 2017: International Journal of Pediatric Otorhinolaryngology
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