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https://www.readbyqxmd.com/read/28322549/vitamin-c-modulates-the-immunotoxic-effect-of-17-alpha-methyltestosterone-in-nile-tilapia
#1
Haitham G Abo-Al-Ela, Abeer F El-Nahas, Shawky Mahmoud, Essam M Ibrahim
The synthetic androgen, 17 alpha-methyltestosterone (MT), is profusely used and practically needed in the production of all-male Nile tilapia fry; however, such androgenic hormones badly disrupt the immune system. This study aimed to alleviate or counteract the immunotoxic effect of MT using vitamin C (ascorbic acid, vit C). Our results show that the highest phagocytic activity (PA), phagocytic index (PI) and lysozyme activity were detected in the vit C group and the MT plus vit C group. Furthermore, PA and PI were significantly suppressed, but lysozyme activity was stronger in the MT group than the control...
March 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/28315936/peptide-binding-motifs-of-two-common-equine-class-i-mhc-molecules-in-thoroughbred-horses
#2
Tobias Bergmann, Mikaela Lindvall, Erin Moore, Eugene Moore, John Sidney, Donald Miller, Rebecca L Tallmadge, Paisley T Myers, Stacy A Malaker, Jeffrey Shabanowitz, Nikolaus Osterrieder, Bjoern Peters, Donald F Hunt, Douglas F Antczak, Alessandro Sette
Quantitative peptide-binding motifs of MHC class I alleles provide a valuable tool to efficiently identify putative T cell epitopes. Detailed information on equine MHC class I alleles is still very limited, and to date, only a single equine MHC class I allele, Eqca-1*00101 (ELA-A3 haplotype), has been characterized. The present study extends the number of characterized ELA class I specificities in two additional haplotypes found commonly in the Thoroughbred breed. Accordingly, we here report quantitative binding motifs for the ELA-A2 allele Eqca-16*00101 and the ELA-A9 allele Eqca-1*00201...
March 18, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28306670/innovations-in-cardiac-transplantation
#3
Reema Hasan, Ashraf Abou El Ela, Daniel Goldstein
PURPOSE OF REVIEW: As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS: Preliminary studies into donation after cardiac death have indicated that this may be an effective means to increase the donor pool. Novel preservation techniques that include ex-vivo perfusion to improve donor metabolic stabilization prior to implantation may also expand the donor pool...
March 16, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28293528/intermediate-phenotype-between-adult-syndrome-and-eec-syndrome-caused-by-r243q-mutation-in-tp63
#4
Yuki Otsuki, Koichi Ueda, Chisei Satoh, Ryuta Maekawa, Koh-Ichiro Yoshiura, Sachiko Iseki
A patient who had ectrodactyly, dry skin, exfoliative dermatitis, and hypodontia with peg-shaped teeth, but not cleft lip and palate, is described. Ectrodactyly with a tooth anomaly is recognized in both acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome and ectrodactyly-ectodermal dysplasia-cleft (EEC) syndrome. These 2 syndromes are caused by heterozygous mutations in the transcriptional factor gene p63. Mutation analysis of p63 gene showed a heterozygous mutation c.728G>A, p.Arg243Gln (previously referred to as R204Q) in the patient, but not in his parents...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28288661/sinus-tarsi-approach-versus-extensile-lateral-approach-for-displaced-intra-articular-calcaneal-fracture-a-meta-analysis-of-current-evidence-base
#5
Hui Yao, Tangzhao Liang, Yichun Xu, Gang Hou, Lulu Lv, Junbin Zhang
BACKGROUND: The extensile lateral approach (ELA) has been widely performed for displaced intra-articular calcaneal fractures (DIACFs), and wound complications remain a significant problem. As a minimal incision technique, the sinus tarsi approach (STA) was designed to overcome this disadvantage. There were already many reports about this approach but the conclusions were not completely consistent. Based on the current evidence, we performed this meta-analysis to compare the STA with ELA in the management of DIACF and expected to draw a certain and meaningful conclusion...
March 14, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28285988/essential-parameters-and-risk-factors-of-the-patients-for-diabetes-care-and-treatment
#6
Abdulbari Bener, Fatma Ela Keskin, Eda M Kurtulus, Mustafa Guzel, Elif I Çekirdekçi, Pınar Kadıoğlu, Dildar Konukoğlu, Mustafa Öztürk
AIM: The aim was to explore the association between Type 2 Diabetes Mellitus [T2DM] treatment satisfactions of patients regarding their socio-economic, life-style, history medication and clinical outcome in a Turkish population SUBJECT AND METHODS: A cross-sectional study conducted from February 2016 to September 2016. Of the total 1500 diabetic patients approached, 1094 (72.9%) gave their consent. Data analysis included, sociodemographic, serum lipid profiles (LDL, HDL), calcium, uric acid, blood pressure and glycated hemoglobin (HbA1c) at baseline and after six months...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28280516/evaluation-of-analgesic-activity-of-papaver-libanoticum-extract-in-mice-involvement-of-opioids-receptors
#7
Mohamad Ali Hijazi, Ahmed El-Mallah, Maha Aboul-Ela, Abdalla Ellakany
Papaver libanoticum is an endemic plant to Lebanese region (family Papaveraceae) that has not been investigated before. The present study aimed to explore the analgesic activity of dried ethanolic extract of Papaver libanoticum (PLE) using tail flick, hot plate, and acetic acid induced writhing models in mice. The involvement of opioid receptors in the analgesic mechanism was investigated using naloxone antagonism. Results demonstrated that PLE exhibited a potent dose dependent analgesic activity in all tested models for analgesia...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28266874/development-and-validation-of-a-scale-to-measure-adolescent-sexual-and-reproductive-health-stigma-results-from-young-women-in-ghana
#8
Kelli Stidham Hall, Abubakar Manu, Emmanuel Morhe, Lisa H Harris, Dana Loll, Elizabeth Ela, Giselle Kolenic, Jessica L Dozier, Sneha Challa, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Vanessa K Dalton
Young women's experiences with sexual and reproductive health (SRH) stigma may contribute to unintended pregnancy. Thus, stigma interventions and rigorous measures to assess their impact are needed. Based on formative work, we generated a pool of 51 items on perceived stigma around different dimensions of adolescent SRH and family planning (sex, contraception, pregnancy, childbearing, abortion). We tested items in a survey study of 1,080 women ages 15 to 24 recruited from schools, health facilities, and universities in Ghana...
March 7, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28245185/harmonization-protocols-for-tsh-immunoassays-a-multicenter-study-in-italy
#9
Aldo Clerico, Andrea Ripoli, Antonio Fortunato, Antonio Alfano, Cinzia Carrozza, Mario Correale, Ruggero Dittadi, Gianluca Gessoni, Marco Migliardi, Sara Rizzardi, Concetta Prontera, Silvia Masotti, Giancarlo Zucchelli, Cristina Guiotto, Palma Aurelia Iacovazzi, Iervasi Giorgio
BACKGROUND: Systematic difference between thyroid-stimulating hormone (TSH) immunoassays may produce misleading interpretation when samples of the same patients are measured with different methods. The study aims were to evaluate whether systematic differences are present among TSH immunoassays, and whether it is possible to obtain a better harmonization among TSH methods using results obtained in external quality assessment (EQA) schemes. METHODS: Seven Italian clinical laboratories measured TSH in 745 serum samples of healthy subjects and patients with thyroid disorders...
February 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28238379/anthropogenic-mercury-deposition-in-flin-flon-manitoba-and-the-experimental-lakes-area-ontario-canada-a-multi-lake-sediment-core-reconstruction
#10
Johan A Wiklund, Jane L Kirk, Derek C G Muir, Marlene Evans, Fan Yang, Jonathan Keating, Matthew T Parsons
High-resolution records of anthropogenic mercury (Hg) deposition were constructed from 9 lakes located 5-75km from the Flin Flon, Manitoba smelter (formerly one of North America's largest atmospheric Hg point sources) and 5 lakes in Experimental Lakes Area (ELA), Ontario; a region remote from major Hg point sources. Anthropogenic Hg deposition, as both a flux and inventory, was determined after accounting for lake-specific natural Hg background concentrations, changes in sedimentation and sediment focusing...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28222221/elastase-2-an-angiotensin-ii-generating-enzyme-contributes-to-increased-ang-ii-in-resistance-arteries-of-mice-with-myocardial-infarction
#11
Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II-generation in resistance arteries are unknown. We hypothesized that ELA-2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI...
February 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28216579/a-plant-proteinase-inhibitor-from-enterolobium-contortisiliquum-attenuates-pulmonary-mechanics-inflammation-and-remodeling-induced-by-elastase-in-mice
#12
Osmar Aparecido Theodoro-Júnior, Renato Fraga Righetti, Rafael Almeida-Reis, Bruno Tadeu Martins-Oliveira, Leandro Vilela Oliva, Carla Máximo Prado, Beatriz Mangueira Saraiva-Romanholo, Edna Aparecida Leick, Nathalia Montouro Pinheiro, Yara Aparecida Lobo, Mílton de Arruda Martins, Maria Luiza Vilela Oliva, Iolanda de Fátima Lopes Calvo Tibério
Proteinase inhibitors have been associated with anti-inflammatory and antioxidant activities and may represent a potential therapeutic treatment for emphysema. Our aim was to evaluate the effects of a plant Kunitz proteinase inhibitor, Enterolobium contortisiliquum trypsin inhibitor (EcTI), on several aspects of experimental elastase-induced pulmonary inflammation in mice. C57/Bl6 mice were intratracheally administered elastase (ELA) or saline (SAL) and were treated intraperitoneally with EcTI (ELA-EcTI, SAL-EcTI) on days 1, 14 and 21...
February 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211187/deletion-of-junctional-adhesion-molecule-a-from-platelets-increases-early-stage-neointima-formation-after-wire-injury-in-hyperlipidemic-mice
#13
Zhen Zhao, Tanja Vajen, Ela Karshovska, Annemiek Dickhout, Martin M Schmitt, Remco T A Megens, Philipp von Hundelshausen, Thomas A Koeppel, Tilman M Hackeng, Christian Weber, Rory R Koenen
Platelets play an important role in the pathogenesis of vascular remodelling after injury. Junctional adhesion molecule A (JAM-A) was recently described to regulate platelet activation. Specific deletion of JAM-A from platelets resulted in increased reactivity and in accelerated progression of atherosclerosis. The aim of this study was to investigate the specific contribution of platelet-derived JAM-A to neointima formation after vascular injury. Mice with or without platelet-specific (tr)JAM-A-deficiency in an apolipoprotein e (apoe(-/-) ) background underwent wire-induced injury of the common carotid artery...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28207505/efficacy-of-1st-line-bismuth-containing-quadruple-therapies-with-levofloxacin-or-clarithromycin-for-the-eradication-of-helicobacter-pylori-infection-a-1-week-open-label-randomized-trial
#14
RANDOMIZED CONTROLLED TRIAL
Jing Su, Xiaoying Zhou, Han Chen, Bo Hao, Weifeng Zhang, Guoxin Zhang
BACKGROUND: The aim of the present open-label, randomized control trial was to determine the clinical efficacy and safety of two 1-week bismuth-containing quadruple regimens and 1 levofloxacin-based triple regimen for the eradication of Helicobacter pylori infection in treatment-naive patients. The influence of susceptibility and host CYP2C19 polymorphisms on the efficacy was also evaluated. METHODS: Eligible patients were randomly to receive esomeprazole and colloidal bismuth pectin along with clarithromycin and amoxicillin (EBCA), esomeprazole and colloidal bismuth pectin along with levofloxacin and amoxicillin (EBLA), or esomeprazole along levofloxacin and amoxicillin (ELA) for 1 week...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28202012/early-life-adversity-is-associated-with-a-smaller-hippocampus-in-male-but-not-female-depressed-in-patients-a-case-control-study
#15
Romain Colle, Tomoyuki Segawa, Marie Chupin, Minh Ngoc Thien Kim Tran Dong, Patrick Hardy, Bruno Falissard, Olivier Colliot, Denis Ducreux, Emmanuelle Corruble
BACKGROUND: Three studies assessed the association of early life adversity (ELA) and hippocampal volumes in depressed patients, of which one was negative and the two others did not control for several potential confounding variables. Since the association of ELA and hippocampal volumes differ in male and female healthy volunteers, we investigated the association of ELA and hippocampal volumes in depressed patients, while focusing specifically on sex and controlling for several relevant socio-demographic and clinical variables...
February 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28196797/left-atrial-structure-in-relationship-to-age-sex-ethnicity-and-cardiovascular-risk-factors-mesa-multi-ethnic-study-of-atherosclerosis
#16
Filip Zemrak, Bharath Ambale-Venkatesh, Gabriella Captur, Jonathan Chrispin, Ela Chamera, Mohammadali Habibi, Saman Nazarian, Saidi A Mohiddin, James C Moon, Steffen E Petersen, João A C Lima, David A Bluemke
BACKGROUND: Left atrial (LA) size is a marker of diastolic function and is associated with atrial fibrillation and cardiovascular outcomes. However, there are no large population studies measuring LA structure. The relationship of demographics and cardiovascular risk factors to LA size is largely unknown. This study aimed to determine associations of LA size with demographic factors, cardiac structure and function, and cardiovascular risk factors. METHODS AND RESULTS: LA volume indexed to body surface area was measured by cardiovascular magnetic resonance steady-state free precession and fast gradient echo cine long- and short-axis images in 2576 asymptomatic participants of MESA ([Multi-Ethnic Study of Atherosclerosis] 68...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28192646/higher-expression-of-toll-like-receptors-3-7-8-and-9-in-pityriasis-rosea
#17
Mostafa Abou El-Ela, Mohamed El-Komy, Rania Abdel Hay, Rehab Hegazy, Amin Sharobim, Laila Rashed, Khalda Amr
BACKGROUND: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. METHODS: Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations...
March 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28187367/ontology-based-automatic-identification-of-public-health-related-turkish-tweets
#18
Emine Ela Küçük, Kürşad Yapar, Dilek Küçük, Doğan Küçük
Social media analysis, such as the analysis of tweets, is a promising research topic for tracking public health concerns including epidemics. In this paper, we present an ontology-based approach to automatically identify public health-related Turkish tweets. The system is based on a public health ontology that we have constructed through a semi-automated procedure. The ontology concepts are expanded through a linguistically motivated relaxation scheme as the last stage of ontology development, before being integrated into our system to increase its coverage...
February 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28182578/review-of-heavy-metal-accumulation-on-aquatic-environment-in-northern-east-mediterrenean-sea-part-i-some-essential-metals
#19
Ayşe Bahar Yılmaz, Alper Yanar, Ela Nur Alkan
All pollutants can reach the aquatic environments and the levels of heavy metals in upper members of the food web like fish can reach values many times higher than those found in aquatic environment or in sediments. Although heavy metals are essential or non-essential, all heavy metals are potentially harmful to humans and most organisms at some level of exposure and absorption. Marine organisms are good indicators for long-term monitoring of metal accumulation. The present review study is for evaluation of the data from previous studies about the toxic effects of selected heavy metals, like essential metals (copper, zinc, iron, chromium, and manganese), on seawater, sediment, and in different tissues of aquatic animals (demersal and bentic fish, invertabres) collected from different areas in Northern East Mediterrenean Sea since the 1990s...
March 1, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28177598/surface-engineering-of-polycrystalline-silicon-for-long-term-mechanical-stress-endurance-enhancement-in-flexible-low-temperature-poly-si-thin-film-transistors
#20
Bo-Wei Chen, Ting-Chang Chang, Kuan-Chang Chang, Yu-Ju Hung, Shin-Ping Huang, Hua-Mao Chen, Po-Yung Liao, Yu-Ho Lin, Hui-Chun Huang, Hsiao-Cheng Chiang, Chung-I Yang, Yu-Zhe Zheng, Ann-Kuo Chu, Hung-Wei Li, Chih-Hung Tsai, Hsueh-Hsing Lu, Terry Tai-Jui Wang, Tsu-Chiang Chang
The surface morphology in polycrystalline silicon (poly-Si) film is an issue regardless of whether conventional excimer laser annealing (ELA) or the newer metal-induced lateral crystallization (MILC) process is used. This paper investigates the stress distribution while undergoing long-term mechanical stress and the influence of stress on electrical characteristics. Our simulated results show that the nonuniform stress in the gate insulator is more pronounced near the polysilicon/gate insulator edge and at the two sides of the polysilicon protrusion...
March 21, 2017: ACS Applied Materials & Interfaces
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