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https://www.readbyqxmd.com/read/29306245/turkish-version-of-the-motor-function-measure-scale-mfm-32-forneuromuscular-diseases-a-cross-cultural-adaptation-reliability-and-validity-study
#1
Habibe Serap İnal, Ela Tarakçı, Devrim Tarakçı, Gülcan Aksoy, Sezan Mergen Kılıç, Hakan Beşer, Çiğdem Beşer, Arzu Razak Özdinçler, Hacer Durmuş Tekçe, Fatma Yeşim Parman, Feza Deymeer, Zehra Piraye Oflazer
Background/aim: The Motor Function Measure (MFM-32) is a classification system for ambulant and nonambulant patients with neuromuscular diseases (NMDs). We aimed to translate it into Turkish, culturally adapt it, and test its reliability and validity for Turkish patients with NMDs.Materials and methods: The translation of the 32 items assessing three functional areas: standing position and transfers (D1: 13), axial/proximal (D2: 12), and distal (D3: 7) motor functions was performed according to the established guidelines for cross-cultural adaptation...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29296664/long-range-organization-of-membrane-curving-proteins
#2
Mijo Simunovic, Anđela Šarić, J Michael Henderson, Ka Yee C Lee, Gregory A Voth
Biological membranes have a central role in mediating the organization of membrane-curving proteins, a dynamic process that has proven to be challenging to probe experimentally. Using atomic force microscopy, we capture the hierarchically organized assemblies of Bin/amphiphysin/Rvs (BAR) proteins on supported lipid membranes. Their structure reveals distinct long linear aggregates of proteins, regularly spaced by up to 300 nm. Employing accurate free-energy calculations from large-scale coarse-grained computer simulations, we found that the membrane mediates the interaction among protein filaments as a combination of short- and long-ranged interactions...
December 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29295664/effect-of-different-combination-of-maternal-and-postnatal-diet-on-adipose-tissue-morphology-in-male-rat-offspring
#3
Darija Šnajder, Željka Perić Kačarević, Anđela Grgić, Nikola Bijelić, Matija Fenrich, Tatjana Belovari, Radivoje Radić
PURPOSE: Adipose tissue expansion can occur through several different ways and, under certain conditions, can be connected with chronic inflammation. TNF-α is one of the important cytokines involved in this process. Prolonged inflammation in obesity can lead to obesity-related insulin resistance and tissue dysfunction. The aim of our study was to investigate how different combination of maternal and postnatal diet affects offspring adipose tissue morphology and adipose tissue TNF-α expression...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29260593/determinants-of-glucose-metabolism-and-the-role-of-npy-in-the-progression-of-insulin-resistance-in-chronic-migraine
#4
Zeynep Oşar Siva, Derya Uluduz, Fatma Ela Keskin, Feyza Erenler, Huriye Balcı, Uğur Uygunoğlu, Sabahattin Saip, Baki Göksan, Aksel Siva
Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic β-cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29243256/the-effectiveness-of-platelet-rich-plasma-in-an-anosmia-induced-mice-model
#5
Ahmet Gorkem Yasak, Ozgur Yigit, Ela Araz Server, Sevgi Durna Dastan, Mehmet Gul
OBJECTIVE: In this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet-rich plasma (PRP) on anosmia in a mouse model of anosmia. STUDY DESIGN: Animal study. METHODS: A total of 16 male mice were included. When selecting the mice, the food-finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3-methylindole. The mice were randomly divided into two groups of eight (groups A and B)...
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29240854/upregulation-of-extracellular-matrix-genes-corroborates-clinical-efcacy-of-human-fibroblast-derived-growth-factors-in-skin-rejuvenation
#6
Kuniko Kadoya, Elizabeth T Makino, Lily I Jiang, Michael Bachelor, Robin Chung, Priscilla Tan, Tsing Cheng, Gail K Naughton, Rahul C Mehta
<p>Skin care products may use various active ingredients to support skin rejuvenation including growth factors and other molecules that help to regenerate extracellular matrix (ECM) and promote skin repair. The biological effect of skin care products with a strong anti-aging claim was assessed in gene expression analyses using an in vitro human skin model. Application of products containing human fbroblast-derived growth factors resulted in signifcant upregulation of genes encoding ECM components including collagens and elas-tin...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240268/assessment-of-procoagulant-potential-in-patients-with-reactive-thrombocytosis-and-its-association-with-platelet-count
#7
Amihai Rottenstreich, Ela Shai, Geffen Kleinstern, Galia Spectre, David Varon, Yosef Kalish
OBJECTIVE: We aimed to determine hemostatic changes and characterize the procoagulant potential among reactive thrombocytosis (RT) patients. METHODS: Sixty RT patients (median platelet count 718X109 /L) and 20 healthy persons were tested for complete blood count, C-reactive protein, von Willebrand factor (VWF), factor VIII and fibrinogen, and thrombin generation. Platelet studies, including light transmission aggregometry and Cone and Plate(let) Analyzer, were also conducted...
December 14, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29237154/effects-of-early-life-adversity-on-hippocampal-structures-and-associated-hpa-axis-functions
#8
Brigitte Dahmen, Vanessa B Puetz, Wolfgang Scharke, Georg G von Polier, Beate Herpertz-Dahlmann, Kerstin Konrad
Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially in brain structures such as the hippocampus, and with dysfunction of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced ELA are also more likely to suffer from mental health disorders such as depression later in life. The exact interplay of aberrant neurodevelopment and HPA axis dysfunction as risks for psychopathology is not yet clear...
December 14, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29235089/early-life-adversity-induced-third-ventricular-enlargement-in-young-adult-male-patients-suffered-from-major-depressive-disorder-a-study-of-brain-morphology
#9
Hongyi Zhao, Tingying Wei, Xiuzhen Li, Ter Ba
BACKGROUND: Early life adversity (ELA) is not uncommon in Major Depressive Disorder (MDD) patients. Childhood trauma has been reported more frequently in adult MDD patients relative to healthy control. Recent researches have demonstrated that ELA could result in changes in brain morphology which might be an etiological factor of MDD development. MATERIALS AND METHODS: We recruited 40 young adult patients suffered from MDD and made CT scan. Subjects were divided in two groups: MDD patients with ELA experience (E+D) vs MDD patients without ELA experience (E-D) according to Chinese version-Childhood Trauma Questionnaire (CTQ)...
December 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29223859/outcome-of-pediatric-renal-transplantation-in-urological-versus-non-urological-causes-of-end-stage-renal-disease-does-it-matter
#10
Ahmed Aly Hussein, Ahmed Ismail Shoukry, Fatina Fadel, Hani Abdel-Raouf Morsi, Hussein Aly Hussein, Mostafa Sheba, Nada El-Khateeb, Waseem Abou-El Ela, Mohamed El-Sheemy, Kareem Daw, Ahmed Shouman, Amr Lotfy, Hisham Badawy, Mohamed Eissa
INTRODUCTION: Causes for end stage renal disease (ESRD) in children can be categorized into urological causes or non-urological causes. We sought to compare the outcomes of urological and non-urological causes of ESRD in children. METHODS: Patients were divided into two groups: urological causes of ESRD versus non-urological causes of ESRD. All patients and donors had at least 6 months of follow-up. The main outcomes included the effect on complications and renal function...
November 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29220884/a-black-swan-in-clinical-laboratory-practice-the-analytical-error-due-to-interferences-in-immunoassay-methods
#11
Aldo Clerico, Lucia Belloni, Cinzia Carrozza, Mario Correale, Ruggero Dittadi, Claudio Dotti, Antonio Fortunato, Giulio Vignati, Gian Carlo Zucchelli, Marco Migliardi
It is well known that the results of immunoassay methods can be affected by specific or non-specific interferences, ranging from 0.4% to 4.0%. The presence of interference may greatly compromise the accuracy of immunoassay analyses causing an error in the measurement, producing false-positive or false-negative results. From a clinical point of view, these analytical errors may have serious implications for patient care because they can cause misdiagnosis or inappropriate treatment. Unfortunately, it is a very difficult task to identify the irregular analytical errors related to immunoassay methods because they are not detectable by normal laboratory quality control procedures, are reproducible within the test system, may be clinically plausible and are relatively rare...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29186589/detergent-insoluble-proteins-and-inclusion-body-like-structures-immunoreactive-for-prkdc-dna-pk-dna-pkcs-ftl-nnt-and-aifm1-in-the-amygdala-of-cognitively-impaired-elderly-persons
#12
Jozsef Gal, Jing Chen, Yuriko Katsumata, David W Fardo, Wang-Xia Wang, Sergey Artiushin, Douglas Price, Sonya Anderson, Ela Patel, Haining Zhu, Peter T Nelson
Misfolded protein in the amygdala is a neuropathologic feature of Alzheimer disease and many other neurodegenerative disorders. We examined extracts from human amygdala (snap-frozen at autopsy) to investigate whether novel and as yet uncharacterized misfolded proteins would be detectable. Polypeptides from the detergent-insoluble, urea-soluble protein fractions of amygdala were interrogated using liquid chromatography-electrospray ionization-tandem mass spectrometry. Among the detergent-insoluble proteins identified in amygdala of demented subjects but not controls were Tau, TDP-43, Aβ, α-synuclein, and ApoE...
November 24, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29186501/the-amygdala-as-a-locus-of-pathologic-misfolding-in-neurodegenerative-diseases
#13
Peter T Nelson, Erin L Abner, Ela Patel, Sonya Anderson, Donna M Wilcock, Richard J Kryscio, Linda J Van Eldik, Gregory A Jicha, Zsombor Gal, Ruth S Nelson, Bela G Nelson, Jozsef Gal, Md Tofial Azam, David W Fardo, Matthew D Cykowski
Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged brains often is accompanied by the misfolding of other proteins, suggesting synergistic mechanisms. The multiplicity of pathogenic processes in human amygdalae has potentially important implications for the pathogenesis of Alzheimer disease, Lewy body diseases, chronic traumatic encephalopathy, primary age-related tauopathy, and hippocampal sclerosis, and for the biomarkers used to diagnose those diseases...
January 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29165895/adaptation-and-validation-of-the-turkish-version-of-the-nasal-obstruction-symptom-evaluation-scale
#14
Ozlem Onerci Celebi, Ela Araz Server, Ozgur Yigit, Ecem Sevim Longur
BACKGROUND: The Nasal Obstruction Symptom Evaluation (NOSE) scale is a questionnaire used to assess the quality of life in patients with nasal obstruction. The aim of this study was to validate the Turkish translation of the NOSE questionnaire. METHODS: The NOSE questionnaire was translated into Turkish and then back to English. Fifty patients with septal deviation leading to nasal obstruction and 50 healthy subjects without any nasal complaints and pathologies were recruited into the study...
November 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29161882/redox-active-quinones-chelators-as-possible-antitumor-drugs-properties-mechanisms-of-action-cells-delivery-and-cells-toxicity
#15
Nikolaj Polyakov, Tatyana Leshina, Lidiya Fedenok, Irina Slepneva, Igor A Kirilyuk, Justina Furso, Magdalena M Olchawa, Tadeusz Sarna, Martyna Elas, Itzhak Bilkis, Lev Weiner
SIGNIFICANCE: Chemotherapy is currently the principal method for treating many malignancies. Thus, development of improved antitumor drugs with enhanced efficacy and selectivity remains a high priority. Recent Advances: Anthracycline antibiotics (AAs), e.g., doxorubicin, daunomycin, and mitomycin C, are an important family of antitumor agents widely used in chemotherapy. All these compounds are quinones. They are thus capable of being reduced by appropriate chemicals or reductases. One of their important properties is that under aerobic conditions their reduced forms undergo oxidation, with concomitant production of reactive oxygen species (ROS), i...
November 22, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29161034/dynamic-glycosylation-governs-the-vertebrate-copii-protein-trafficking-pathway
#16
Nathan J Cox, Gokhan Unlu, Brittany J Bisnett, Thomas R Meister, Brett Condon, Peter M Luo, Tim J Smith, Michael Hanna, Abhishek Chhetri, Erik J Soderblom, Anjon Audhya, Ela W Knapik, Michael Boyce
The COPII coat complex, which mediates secretory cargo trafficking from the endoplasmic reticulum, is a key control point for subcellular protein targeting. Because misdirected proteins cannot function, protein sorting by COPII is critical for establishing and maintaining normal cell and tissue homeostasis. Indeed, mutations in COPII genes cause a range of human pathologies, including cranio-lenticulo-sutural dysplasia (CLSD), which is characterized by collagen trafficking defects, craniofacial abnormalities and skeletal dysmorphology...
November 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/29158909/first-complete-genome-sequence-of-circulating-dengue-virus-serotype-3-in-jeddah-saudi-arabia
#17
A M Hashem, S S Sohrab, S A El-Kafrawy, S A El-Ela, A M M Abd-Alla, S A Farraj, N A Othman, A M Hassan, M M El-Daly, R N Charrel, T A Madani, E I Azhar
Here we report the first full-length genome sequence of dengue virus serotype 3 (DENV-3) from a strain isolated from a patient in Jeddah, Saudi Arabia, in 2014. The genome consists of 10 635 bp and shows close similarity to circulating genotype III isolates from Singapore, suggesting possible importation, most probably during religious pilgrimages to Saudi Arabia.
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29158715/optimized-furosemide-taste-masked-orally-disintegrating-tablets
#18
Mohamed Abbas Ibrahim, Amal El Sayeh F Abou El Ela
Optimized orally disintegrating tablets (ODTs) containing furosemide (FUR) were prepared by direct compression method. Two factors, three levels (3(2)) full factorial design was used to optimize the effect of taste masking agent (Eudragit E100; X1) and superdisintegarant; croscarmellose sodium (CCS; X2) on tablet properties. A composite was prepared by mixing ethanolic solution of FUR and Eudragit E100 with mannitol prior to mixing with other tablet ingredients. The prepared ODTs were characterized for their FUR content, hardness, friability and wetting time...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29155919/neonatal-outcomes-in-a-medicaid-population-with-opioid-dependence
#19
Susan B Brogly, Sonia Hernández-Diaz, Emily Regan, Ela Fadli, Kristen A Hahn, Martha M Werler
Confounding may account for the apparent improved infant outcomes after prenatal exposure to buprenorphine versus methadone. We used Massachusetts Medicaid Analytic eXtract (MAX) data to identify a cohort of opioid dependent mother-infant pairs (2006-2011) supplemented with confounder data from an external Boston cohort (2015-2016). Associations between prenatal buprenorphine versus methadone exposure and infant outcomes in the MAX Cohort were adjusted for measured MAX confounders, and unmeasured confounders with bias analysis using External Cohort data...
November 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29153626/the-association-between-paternal-and-adolescent-depressive-symptoms-evidence-from-two-population-based-cohorts
#20
Gemma Lewis, Martha Neary, Ela Polek, Eirini Flouri, Glyn Lewis
BACKGROUND: Incidence of depression increases markedly around age 13 years, and nearly three-quarters of adults report that their mental health problems started in adolescence. Although maternal depression is a risk factor for adolescent depression, evidence about the association between paternal and adolescent depression is inconclusive, and many studies have methodological limitations. We aimed to assess the association between paternal and adolescent depressive symptoms in two large population-based cohort studies...
December 2017: Lancet Psychiatry
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