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https://www.readbyqxmd.com/read/28439197/clinical-and-polysomnographic-features-of-children-evaluated-with-polysomnography-in-pediatric-sleep-laboratory
#1
Hatice Ezgi Barış, Yasemin Gökdemir, Ela Erdem Eralp, Nilay Baş İkizoğlu, Fazilet Karakoç, Bülent Karadağ, Refika Ersu
AIM: Sleep disordered breathing is a common problem in childhood that encompasses a spectrum of disorders extending from primary snoring to obstructive sleep apnea. This study aims to investigate the results of children undergoing evaluation with polysomnography in the sleep laboratory of a tertiary care hospital. MATERIAL AND METHODS: Demographic and clinical features as well as sleep associated symptoms, scores of pediatric sleep questionnaire and Pittsburgh sleep quality index and polysomnography results are retrospectively evaluated...
March 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28439003/numerical-evidence-for-thermally-induced-monopoles
#2
Peter Wirnsberger, Domagoj Fijan, Roger A Lightwood, Anđela Šarić, Christoph Dellago, Daan Frenkel
Electric charges are conserved. The same would be expected to hold for magnetic charges, yet magnetic monopoles have never been observed. It is therefore surprising that the laws of nonequilibrium thermodynamics, combined with Maxwell's equations, suggest that colloidal particles heated or cooled in certain polar or paramagnetic solvents may behave as if they carry an electric/magnetic charge. Here, we present numerical simulations that show that the field distribution around a pair of such heated/cooled colloidal particles agrees quantitatively with the theoretical predictions for a pair of oppositely charged electric or magnetic monopoles...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28419315/clinical-parameters-routine-inflammatory-markers-and-lta4h-genotype-as-predictors-of-mortality-among-608-patients-with-tuberculous-meningitis-in-indonesia
#3
Arjan van Laarhoven, Sofiati Dian, Carolien Ruesen, Ela Hayati, Michelle S M A Damen, Jessi Annisa, Lidya Chaidir, Rovina Ruslami, Tri Hanggono Achmad, Mihai G Netea, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel
Background.: Damaging inflammation is thought to contribute to the high morbidity and mortality of tuberculous meningitis (TBM), but the link between inflammation and outcome remains unclear. Methods.: We performed prospective clinical and routine laboratory analyses of a cohort of adult patients with TBM in Indonesia. We also examined the LTA4H promoter polymorphism, which predicted cerebrospinal fluid (CSF) leukocyte count and survival of Vietnamese patients with TBM...
April 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28402865/inhibition-versus-facilitation-of-contralesional-motor-cortices-in-stroke-deriving-a-model-to-tailor-brain-stimulation
#4
Vishwanath Sankarasubramanian, Andre G Machado, Adriana B Conforto, Kelsey A Potter-Baker, David A Cunningham, Nicole M Varnerin, Xiaofeng Wang, Ken Sakaie, Ela B Plow
OBJECTIVE: The standard approach to brain stimulation in stroke is based on the premise that ipsilesional M1 (iM1) is important for motor function of the paretic upper limb, while contralesional cortices compete with iM1. Therefore, the approach typically advocates facilitating iM1 and/or inhibiting contralesional M1 (cM1). But, this approach fails to elicit much improvement in severely affected patients, who on account of extensive damage to ipsilesional pathways, cannot rely on iM1...
March 21, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28400598/molecular-dynamics-study-of-ferroelectric-domain-nucleation-and-domain-switching-dynamics
#5
Vishal Boddu, Florian Endres, Paul Steinmann
Ferroelectric materials contain domains of ordered electric dipoles, separated by domain walls, that can undergo polarisation switching under externally applied electric fields. The domain switching dynamics in ferroelectric materials plays an essential role in their application to electronic and electro-optic de- vices. Previous studies suggest that the switching occurs largely through domain wall motion which is explained from the viewpoint of statistical physics on surface growth as the behaviour of a pinned elas- tic interface...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394279/anti-inflammatory-and-antioxidant-properties-of-casein-hydrolysate-produced-using-high-hydrostatic-pressure-combined-with-proteolytic-enzymes
#6
Fatemeh Bamdad, Seulki Hazel Shin, Joo-Won Suh, Chamila Nimalaratne, Hoon Sunwoo
Casein-derived peptides are shown to possess radical scavenging and metal chelating properties. The objective of this study was to evaluate novel anti-inflammatory properties of casein hydrolysates (CH) produced by an eco-friendly process that combines high hydrostatic pressure with enzymatic hydrolysis (HHP-EH). Casein was hydrolysed by different proteases, including flavourzyme (Fla), savinase (Sav), thermolysin (Ther), trypsin (Try), and elastase (Ela) at 0.1, 50, 100, and 200 MPa pressure levels under various enzyme-to-substrate ratios and incubation times...
April 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28387645/evolution-of-the-hypoxia-sensitive-cells-involved-in-amniote-respiratory-reflexes
#7
Dorit Hockman, Alan J Burns, Gerhard Schlosser, Keith P Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, Gokhan Unlu, Ela W Knapik, Charles K Kaufman, Christian Mosimann, Leonard I Zon, Joseph J Lancman, P Duc S Dong, Heiko Lickert, Abigail S Tucker, Clare Vh Baker
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelial cells' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm...
April 7, 2017: ELife
https://www.readbyqxmd.com/read/28386233/elastase-2-a-tissue-alternative-pathway-for-angiotensin-ii-generation-plays-a-role-in-circulatory-sympathovagal-balance-in-mice
#8
Christiane Becari, Marina T Durand, Alessander O Guimaraes, Renata M Lataro, Cibele M Prado, Mauro de Oliveira, Sarai C O Candido, Paloma Pais, Mauricio S Ribeiro, Michael Bader, Joao B Pesquero, Maria C O Salgado, Helio C Salgado
In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ELA-2 in vivo is unclear. We examined ELA-2 knockout (ELA-2KO) mice compared to wild-type (WT) mice and determined whether ELA-2 played a role in hemodynamics [arterial pressure (AP) and heart rate (HR)], cardiocirculatory sympathovagal balance and baroreflex sensitivity. The variability of systolic arterial pressure (SAP) and pulse interval (PI) for evaluating autonomic modulation was examined for time and frequency domains (spectral analysis), whereas a symbolic analysis was also used to evaluate PI variability...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28380672/randomized-clinical-trial-of-deep-brain-stimulation-for-post-stroke-pain
#9
Scott F Lempka, Donald A Malone, Bo Hu, Kenneth B Baker, Alexandria Wyant, John Ozinga, Ela B Plow, Mayur Pandya, Cynthia S Kubu, Paul J Ford, Andre G Machado
OBJECTIVE: The experience with deep brain stimulation (DBS) for pain is largely based on uncontrolled studies targeting the somatosensory pathways, with mixed results. We hypothesized that targeting limbic neural pathways would modulate the affective sphere of pain and alleviate suffering. METHODS: We conducted a prospective, double-blinded, randomized, placebo-controlled, crossover study of DBS targeting the ventral striatum/anterior limb of the internal capsule (VS/ALIC) in 10 patients with post-stroke pain syndrome...
April 5, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28371822/elabela-apj-axis-protects-from-pressure-overload-heart-failure-and-angiotensin-ii-induced-cardiac-damage
#10
Teruki Sato, Chitose Sato, Ayumi Kadowaki, Hiroyuki Watanabe, Lena Ho, Junji Ishida, Tomokazu Yamaguchi, Akinori Kimura, Akiyoshi Fukamizu, Josef M Penninger, Bruno Reversade, Hiroshi Ito, Yumiko Imai, Keiji Kuba
Aims: : Elabela/Toddler/Apela (ELA) has been identified as a novel endogenous peptide ligand for APJ/Apelin receptor/Aplnr. ELA plays a crucial role in early cardiac development of zebrafish as well as in maintenance of self-renewal of human embryonic stem cells. Apelin was the first identified APJ ligand, and exerts positive inotropic heart effects and regulates the renin-angiotensin system. The aim of this study was to investigate the biological effects of ELA in the cardiovascular system...
March 23, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28368525/menstrual-cycle-hormone-changes-in-women-traversing-the-menopause-study-of-women-s-health-across-the-nation
#11
Nanette Santoro, Sybil L Crawford, Samar R El Khoudary, Amanda A Allshouse, Sherri-Ann Burnett-Bowie, Joel Finkelstein, Carol Derby, Karen Matthews, Howard M Kravitz, Sioban D Harlow, Gail A Greendale, Ellen B Gold, Rasa Kazlauskaite, Dan McConnell, Genevieve Neal-Perry, Jelena Pavlovic, John Randolph, Gerson Weiss, Hsiang-Yu Chen, Bill Lasley
Context: Menstrual cycle hormone patterns in women approaching menopause are inadequately studied. Objective: To describe day-to-day menstrual cycle hormones in women as they approach menopause from the Study of Women's Health Across the Nation (SWAN) Daily Hormone Study (DHS). Design: DHS enrollees collected daily urine for one entire menstrual cycle or up to 50 days, whichever came first, annually, up to the final menstrual period (FMP) or for up to 10 years...
March 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28364299/life-satisfaction-and-psychological-status-of-mothers-with-disabled-children-a-descriptive-study
#12
Emine Ela Küçük, Dilek Küçük Alemdar
The purpose of this study is to determine the life satisfaction, general health conditions, and depression levels of mothers with disabled children and the problems they experienced. This descriptive study was conducted between 1 and 30 December 2014 in a rehabilitation center that renders services for totally 254 physically and mentally-disabled children in Turkey. 184 mothers participated in the study. The data were collected by using an information form, the life satisfaction scale, the general health questionnaire, and the Beck depression inventory...
March 31, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28349045/safety-profile-of-liver-fibroscan-in-patients-with-cardiac-pacemakers-or-implantable-cardioverter-defibrillators
#13
Yin Chan, Stephanie Pranke, Farid Rashidi, Shravan Nosib, Lawrence Worobetz
Background. Emerging evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery diseases and arrhythmias. The FibroScan (Echosens, France), a widely available, noninvasive device, is able to detect liver fibrosis and steatosis within this patient population. However, the FibroScan is currently contraindicated in patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD). Objective. To determine the safety profile of FibroScan testing in patients with PM or ICD...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28337242/mucosal-gastric-calcinosis-in-a-hypocalcaemic-patient
#14
Demet Dincay, Kadri Atay, Ibrahim Hatemi, Nuray Kepil, Fatma Ela Keskin, Tuğçe Apaydın, Pinar Kadioglu
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28335865/zebrafish-developmental-models-of-skeletal-diseases
#15
Lauryn N Luderman, Gokhan Unlu, Ela W Knapik
The zebrafish skeleton shares many similarities with human and other vertebrate skeletons. Over the past years, work in zebrafish has provided an extensive understanding of the basic developmental mechanisms and cellular pathways directing skeletal development and homeostasis. This review will focus on the cell biology of cartilage and bone and how the basic cellular processes within chondrocytes and osteocytes function to assemble the structural frame of a vertebrate body. We will discuss fundamental functions of skeletal cells in production and secretion of extracellular matrix and cellular activities leading to differentiation of progenitors to mature cells that make up the skeleton...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28322549/vitamin-c-modulates-the-immunotoxic-effect-of-17%C3%AE-methyltestosterone-in-nile-tilapia
#16
Haitham G Abo-Al-Ela, Abeer F El-Nahas, Shawky Mahmoud, Essam M Ibrahim
The synthetic androgen 17α-methyltestosterone (MT) is profusely used and practically needed in the production of all-male Nile tilapia fry; however, such androgenic hormones badly disrupt the immune system. This study aimed to alleviate or counteract the immunotoxic effect of MT using vitamin C (ascorbic acid or vit C). Our results show that the highest phagocytic activity (PA), phagocytic index (PI), and lysozyme activity were detected in the vit C group and the MT plus vit C group. Furthermore, PA and PI were significantly suppressed, but lysozyme activity was stronger in the MT group than in the control...
March 28, 2017: Biochemistry
https://www.readbyqxmd.com/read/28315936/peptide-binding-motifs-of-two-common-equine-class-i-mhc-molecules-in-thoroughbred-horses
#17
Tobias Bergmann, Mikaela Lindvall, Erin Moore, Eugene Moore, John Sidney, Donald Miller, Rebecca L Tallmadge, Paisley T Myers, Stacy A Malaker, Jeffrey Shabanowitz, Nikolaus Osterrieder, Bjoern Peters, Donald F Hunt, Douglas F Antczak, Alessandro Sette
Quantitative peptide-binding motifs of MHC class I alleles provide a valuable tool to efficiently identify putative T cell epitopes. Detailed information on equine MHC class I alleles is still very limited, and to date, only a single equine MHC class I allele, Eqca-1*00101 (ELA-A3 haplotype), has been characterized. The present study extends the number of characterized ELA class I specificities in two additional haplotypes found commonly in the Thoroughbred breed. Accordingly, we here report quantitative binding motifs for the ELA-A2 allele Eqca-16*00101 and the ELA-A9 allele Eqca-1*00201...
March 18, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28306670/innovations-in-cardiac-transplantation
#18
Reema Hasan, Ashraf Abou El Ela, Daniel Goldstein
PURPOSE OF REVIEW: As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS: Preliminary studies into donation after cardiac death have indicated that this may be an effective means to increase the donor pool. Novel preservation techniques that include ex-vivo perfusion to improve donor metabolic stabilization prior to implantation may also expand the donor pool...
March 16, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28293528/intermediate-phenotype-between-adult-syndrome-and-eec-syndrome-caused-by-r243q-mutation-in-tp63
#19
Yuki Otsuki, Koichi Ueda, Chisei Satoh, Ryuta Maekawa, Koh-Ichiro Yoshiura, Sachiko Iseki
A patient who had ectrodactyly, dry skin, exfoliative dermatitis, and hypodontia with peg-shaped teeth, but not cleft lip and palate, is described. Ectrodactyly with a tooth anomaly is recognized in both acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome and ectrodactyly-ectodermal dysplasia-cleft (EEC) syndrome. These 2 syndromes are caused by heterozygous mutations in the transcriptional factor gene p63. Mutation analysis of p63 gene showed a heterozygous mutation c.728G>A, p.Arg243Gln (previously referred to as R204Q) in the patient, but not in his parents...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28288661/sinus-tarsi-approach-versus-extensile-lateral-approach-for-displaced-intra-articular-calcaneal-fracture-a-meta-analysis-of-current-evidence-base
#20
Hui Yao, Tangzhao Liang, Yichun Xu, Gang Hou, Lulu Lv, Junbin Zhang
BACKGROUND: The extensile lateral approach (ELA) has been widely performed for displaced intra-articular calcaneal fractures (DIACFs), and wound complications remain a significant problem. As a minimal incision technique, the sinus tarsi approach (STA) was designed to overcome this disadvantage. There were already many reports about this approach but the conclusions were not completely consistent. Based on the current evidence, we performed this meta-analysis to compare the STA with ELA in the management of DIACF and expected to draw a certain and meaningful conclusion...
March 14, 2017: Journal of Orthopaedic Surgery and Research
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