Qu Yue, Zhao Wang, Yixiong Shen, Yufei Lan, Xiangyang Zhong, Xin Luo, Tao Yang, Manqing Zhang, Boming Zuo, Tianci Zeng, Jiankun Lu, Yuankai Wang, Boyang Liu, Hongbo Guo
Temozolomide (TMZ) resistance remains the major obstacle in the treatment of glioblastoma (GBM). Lactylation is a novel post-translational modification that is involved in various tumors. However, whether lactylation plays a role in GBM TMZ resistance remains unclear. Here it is found that histone H3K9 lactylation (H3K9la) confers TMZ resistance in GBM via LUC7L2-mediated intron 7 retention of MLH1. Mechanistically, lactylation is upregulated in recurrent GBM tissues and TMZ-resistant cells, and is mainly concentrated in histone H3K9...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)