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https://www.readbyqxmd.com/read/28107423/characterization-of-the-drug-resistance-profiles-of-patients-infected-with-crf07_bc-using-phenotypic-assay-and-ultra-deep-pyrosequencing
#1
Szu-Wei Huang, Wei-You Li, Wen-Hung Wang, Yu-Ting Lin, Chih-Hung Chou, Marcelo Chen, Hsien-Da Huang, Yen-Hsu Chen, Po-Liang Lu, Sheng-Fan Wang, Shinichi Oka, Yi-Ming Arthur Chen
The usefulness of ultra-deep pyrosequencing (UDPS) for the diagnosis of HIV-1 drug resistance (DR) remains to be determined. Previously, we reported an explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan in 2004. The goal of this study was to characterize the DR of CRF07_BC strains using different assays including UDPS. Seven CRF07_BC isolates including 4 from early epidemic (collected in 2004-2005) and 3 from late epidemic (collected in 2008) were obtained from treatment-naïve patient's peripheral blood mononuclear cells...
2017: PloS One
https://www.readbyqxmd.com/read/28106680/the-explosion-of-virtual-nursing-care
#2
Carol Boston-Fleischhauer
The call for care model innovation is clear, spearheaded by rising healthcare costs, changing payer expectations, overall fiscal and workforce shortages, and an increasingly comorbid patient population requiring significant, long-term support. As part of care model innovation, the leveraging of technology is key.
February 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28105954/the-amp-foot-3-new-generation-propulsive-prosthetic-feet-with-explosive-motion-characteristics-design-and-validation
#3
Pierre Cherelle, Victor Grosu, Manuel Cestari, Bram Vanderborght, Dirk Lefeber
The last decades, rehabilitation has become a challenging context for mechatronical engineering. From the state-of-the-art it is seen that the field of prosthetics offers very promising perspectives to roboticist. Today's prosthetic feet tend to improve amputee walking experience by delivering the necessary push-off forces while walking. Therefore, several new types of (compliant) actuators are developed in order to fulfill the torque and power requirements of a sound ankle-foot complex with minimized power consumption...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28105915/spectral-consensus-strategy-for-accurate-reconstruction-of-large-biological-networks
#4
Séverine Affeldt, Nataliya Sokolovska, Edi Prifti, Jean-Daniel Zucker
BACKGROUND: The last decades witnessed an explosion of large-scale biological datasets whose analyses require the continuous development of innovative algorithms. Many of these high-dimensional datasets are related to large biological networks with few or no experimentally proven interactions. A striking example lies in the recent gut bacterial studies that provided researchers with a plethora of information sources. Despite a deeper knowledge of microbiome composition, inferring bacterial interactions remains a critical step that encounters significant issues, due in particular to high-dimensional settings, unknown gut bacterial taxa and unavoidable noise in sparse datasets...
December 13, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28105792/synthesis-of-poly-phenyltriazolylcarboxylate-s-with-aggregation-induced-emission-characteristics-by-metal-free-1-3-dipolar-polycycloaddition-of-phenylpropiolate-and-azides
#5
Wei Yuan, Weiwen Chi, Ruimin Liu, Hongkun Li, Yongfang Li, Ben Zhong Tang
Two soluble poly(phenyltriazolylcarboxylate)s (PPTCs) with high molecular weights (M w up to 26 800) are synthesized by the metal-free 1,3-dipolar polycycloadditions of 4,4'-isopropylidenediphenyl diphenylpropiolate (1) and tetraphenylethene-containing diazides (2) in dimethylformamide at 150 °C for 12 h in high yields (up to 93%). The resultant polymers are soluble in common organic solvents and are thermally stable with 5% weight loss temperatures higher than 375 °C. The PPTCs are nonemissive in solutions, but become highly luminescent upon aggregation, showing a phenomenon of aggregation-induced emission...
January 20, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28105573/effect-of-movement-velocity-during-resistance-training-on-dynamic-muscular-strength-a-systematic-review-and-meta-analysis
#6
REVIEW
Timothy B Davies, Kenny Kuang, Rhonda Orr, Mark Halaki, Daniel Hackett
BACKGROUND: Movement velocity is an acute resistance-training variable that can be manipulated to potentially optimize dynamic muscular strength development. However, it is unclear whether performing faster or slower repetitions actually influences dynamic muscular strength gains. OBJECTIVE: We conducted a systematic review and meta-analysis to examine the effect of movement velocity during resistance training on dynamic muscular strength. METHODS: Five electronic databases were searched using terms related to movement velocity and resistance training...
January 20, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28102439/reconstruction-of-radionuclide-intakes-for-the-residents-of-east-urals-radioactive-trace-1957-2011
#7
Evgenia I Tolstykh, Lyudmila M Peremyslova, Marina O Degteva, Bruce A Napier
The East Urals Radioactive Trace (EURT) was formed after a chemical explosion in the radioactive waste-storage facility of the Mayak Production Association in 1957 (Southern Urals, Russia) and resulted in an activity dispersion of 7.4 × 10(16) Bq into the atmosphere. Internal exposure due to ingestion of radionuclides with local foodstuffs was the main factor of public exposure at the EURT. The EURT cohort, combining residents of most contaminated settlements, was formed for epidemiological study at the Urals Research Center for Radiation Medicine, Russia (URCRM)...
January 19, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28100256/transcriptomic-signatures-differentiate-survival-from-fatal-outcomes-in-humans-infected-with-ebola-virus
#8
Xuan Liu, Emily Speranza, César Muñoz-Fontela, Sam Haldenby, Natasha Y Rickett, Isabel Garcia-Dorival, Yongxiang Fang, Yper Hall, Elsa-Gayle Zekeng, Anja Lüdtke, Dong Xia, Romy Kerber, Ralf Krumkamp, Sophie Duraffour, Daouda Sissoko, John Kenny, Nichola Rockliffe, E Diane Williamson, Thomas R Laws, Magassouba N'Faly, David A Matthews, Stephan Günther, Andrew R Cossins, Armand Sprecher, John H Connor, Miles W Carroll, Julian A Hiscox
BACKGROUND: In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality. RESULTS: The data demonstrate that individuals who succumbed to the disease show stronger upregulation of interferon signalling and acute phase responses compared to survivors during the acute phase of infection...
January 19, 2017: Genome Biology
https://www.readbyqxmd.com/read/28099029/energy-transfer-between-coherently-delocalized-states-in-thin-films-of-the-explosive-pentaerythritol-tetranitrate-petn-revealed-by-two-dimensional-infrared-spectroscopy
#9
Joshua S Ostrander, Robert Knepper, Alexander S Tappan, Jeffrey J Kay, Martin T Zanni, Darcie A Farrow
Pentaerythritol tetranitrate (PETN) is a common secondary explosive and has been used extensively to study shock initiation and energy propagation in energetic materials. We report 2D IR measurements of PETN thin films that resolve vibrational energy transfer and relaxation mechanisms. Ultrafast anisotropy measurements reveal a sub-500 fs reorientation of transition dipoles in thin films of vapor-deposited PETN that is absent in solution measurements, consistent with intermolecular energy transfer. The anisotropy is frequency dependent, suggesting spectrally heterogeneous vibrational relaxation...
January 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28099018/reactive-ni-al-nanocomposites-structural-characteristics-and-activation-energy
#10
Christopher E Shuck, Alexander S Mukasyan
Stochastically structured Ni/Al reactive nanocomposites (RNCs) were prepared using short term high-energy ball milling. Differing milling times were utilized to prepared RNCs with differing internal nanostructures. These internal structures were quantitatively and statistically analyzed by use of serial focused ion beam sectioning coupled with 3D reconstruction techniques. The reaction kinetics were analyzed using the electrothermal explosion technique for each milling condition. It is shown that the effective activation energy (Eef) ranges from 79-137 kJ/mol and is directly related to the surface area contact between the reactants...
January 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28098836/association-of-school-environment-and-after-school-physical-activity-with-health-related-physical-fitness-among-junior-high-school-students-in-taiwan
#11
Kai-Yang Lo, Min-Chen Wu, Shu-Chin Tung, City C Hsieh, Hsueh-Hua Yao, Chien-Chang Ho
The relationship between students' school environment and exercise habits is complex, and is affected by numerous factors. However, the few studies that have been conducted on this relationship have reported inconsistent results, especially regarding Taiwanese students. We conducted this cross-sectional study to investigate the association of school environment and after-school physical activity with health-related physical fitness in Taiwanese adolescents. Data were drawn from a national survey conducted by the Ministry of Education in Taiwan in 2008 of health-related physical fitness measurements among junior high school students (649,442 total) in grades seven to nine...
January 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098194/new-hydrate-formation-methods-in-a-liquid-gas-medium
#12
A A Chernov, A A Pil'nik, D S Elistratov, I V Mezentsev, A V Meleshkin, M V Bartashevich, M G Vlasenko
Conceptually new methods of hydrate formation are proposed. The first one is based on the shock wave impact on a water-bubble medium. It is shown that the hydrate formation rate in this process is typically very high. A gas hydrate of carbon dioxide was produced. The process was experimentally studied using various initial conditions, as well as different external action magnitudes. The obtained experimental data are in good agreement with the proposed model. Other methods are based on the process of boiling liquefied gas in an enclosed volume of water (explosive boiling of a hydrating agent and the organization of cyclic boiling-condensation process)...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097221/electrospun-core-shell-microfiber-separator-with-thermal-triggered-flame-retardant-properties-for-lithium-ion-batteries
#13
Kai Liu, Wei Liu, Yongcai Qiu, Biao Kong, Yongming Sun, Zheng Chen, Denys Zhuo, Dingchang Lin, Yi Cui
Although the energy densities of batteries continue to increase, safety problems (for example, fires and explosions) associated with the use of highly flammable liquid organic electrolytes remain a big issue, significantly hindering further practical applications of the next generation of high-energy batteries. We have fabricated a novel "smart" nonwoven electrospun separator with thermal-triggered flame-retardant properties for lithium-ion batteries. The encapsulation of a flame retardant inside a protective polymer shell has prevented direct dissolution of the retardant agent into the electrolyte, which would otherwise have negative effects on battery performance...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28095831/a-follow-up-study-of-airway-symptoms-and-lung-function-among-residents-and-workers-5-5%C3%A2-years-after-an-oil-tank-explosion
#14
Jens-Tore Granslo, Magne Bråtveit, Bjørg Eli Hollund, Stein Håkon Låstad Lygre, Cecilie Svanes, Bente Elisabeth Moen
BACKGROUND: Assess if people who lived or worked in an area polluted after an oil tank explosion had persistent respiratory health impairment as compared to a non-exposed population 5.5 years after the event. METHODS: A follow-up study 5.5 years after the explosion, 330 persons aged 18-67 years, compared lung function, lung function decline and airway symptoms among exposed persons (residents <6 km from the accident site or working in the industrial harbour at the time of the explosion) with a non-exposed group (residence >20 km away)...
January 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28095595/critical-infrastructure-vulnerability-to-spatially-localized-failures-with-applications-to-chinese-railway-system
#15
Min Ouyang, Hui Tian, Zhenghua Wang, Liu Hong, Zijun Mao
This article studies a general type of initiating events in critical infrastructures, called spatially localized failures (SLFs), which are defined as the failure of a set of infrastructure components distributed in a spatially localized area due to damage sustained, while other components outside the area do not directly fail. These failures can be regarded as a special type of intentional attack, such as bomb or explosive assault, or a generalized modeling of the impact of localized natural hazards on large-scale systems...
January 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28093589/selective-bond-breaking-of-co2-in-phase-locked-two-color-intense-laser-fields-laser-field-intensity-dependence
#16
Tomoyuki Endo, Hikaru Fujise, Yuuna Kawachi, Ayaka Ishihara, Akitaka Matsuda, Mizuho Fushitani, Hirohiko Kono, Akiyoshi Hishikawa
Selective bond breaking of CO2 in phase-locked ω-2ω two-color intense laser fields (λ = 800 nm and 400 nm, total field intensity I ∼ 10(14) W cm(-2)) has been investigated by coincidence momentum imaging. The CO(+) and O(+) fragment ions produced by two-body Coulomb explosion, CO2(2+) → CO(+) + O(+), exhibit asymmetric distributions along the laser polarization direction, showing that one of the two equivalent C-O bonds is selectively broken by the laser fields. At a field intensity higher than 2 × 10(14) W cm(-2), the largest fragment asymmetry is observed when the relative phase ϕ between the ω and 2ω laser fields is ∼0 and π...
January 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28092595/command-filter-based-adaptive-neural-tracking-controller-design-for-uncertain-switched-nonlinear-output-constrained-systems
#17
Ben Niu, Yanjun Liu, Guangdeng Zong, Zhaoyu Han, Jun Fu
In this paper, a new adaptive approximation-based tracking controller design approach is developed for a class of uncertain nonlinear switched lower-triangular systems with an output constraint using neural networks (NNs). By introducing a novel barrier Lyapunov function (BLF), the constrained switched system is first transformed into a new system without any constraint, which means the control objectives of the both systems are equivalent. Then command filter technique is applied to solve the so-called "explosion of complexity" problem in traditional backstepping procedure, and radial basis function NNs are directly employed to model the unknown nonlinear functions...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28091947/characteristics-of-the-energetic-micro-initiator-through-integrating-al-ni-nano-multilayers-with-cu-film-bridge
#18
Yuxin Zhang, Hongchuan Jiang, Xiaohui Zhao, Yichao Yan, Wanli Zhang, Yanrong Li
An energetic micro-initiator through integrating Al/Ni nano-multilayers with Cu film bridge was investigated in this study. The Cu film bridge was initially fabricated with wet etching, and Al/Ni nano-multilayers were alternately deposited on the surface of Cu film bridge by magnetron sputtering. The periodic layer structure of Al/Ni nano-multilayers was verified by scanning electron microscopy. The exothermic reaction in Al/Ni nano-multilayers can be initiated with onset reaction temperature as low as 503 K, and the total reaction heat is about 774...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28091889/theoretical-insights-into-the-effects-of-molar-ratios-on-stabilities-mechanical-properties-and-detonation-performance-of-cl-20-hmx-cocrystal-explosives-by-molecular-dynamics-simulation
#19
Gui-Yun Hang, Wen-Li Yu, Tao Wang, Jin-Tao Wang, Zhen Li
To research and estimate the effects of molar ratios on structures, stabilities, mechanical properties, and detonation properties of CL-20/HMX cocrystal explosive, the CL-20/HMX cocrystal explosive models with different molar ratios were established in Materials Studio (MS). The crystal parameters, structures, stabilities, mechanical properties, and some detonation parameters of different cocrystal explosives were obtained and compared. The molecular dynamics (MD) simulation results illustrate that the molar ratios of CL-20/HMX have a direct influence on the comprehensive performance of cocrystal explosive...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28091542/on-line-ammonia-sensor-and-invisible-security-ink-by-fluorescent-zwitterionic-spirocyclic-meisenheimer-complex
#20
Tanmay Das, Apurba Pramanik, Debasish Haldar
Ammonia is not only a highly important gas for civilization but also contribute significantly for climate change and human health hazard. Highly sensitive ammonia sensor has been developed from a fluorescent zwitterionic spirocyclic Meisenheimer complex. Moreover, formation of this Meisenheimer complex can also be utilized for selective as well as naked eye instant detection of nitro aromatic explosive picric acid. The presence of a quaternary nitrogen atom directly attached to the spiro carbon is the unique feature of this Meisenheimer complex...
January 16, 2017: Scientific Reports
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