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https://www.readbyqxmd.com/read/29222310/novel-alternate-hemostatic-agents-for-patients-with-inhibitors-beyond-bypass-therapy
#1
REVIEW
Margaret V Ragni
Inhibitor formation is among the most severe complications of hemophilia treatment. With a cumulative incidence of ∼30% in those with severe hemophilia A and ∼3% in those with severe hemophilia B, inhibitors are caused by a T-cell response directed against infused coagulation factor; these inhibitors neutralize factor VIII or IX activity and disrupt normal hemostasis. Inhibitor patients become unresponsive to standard factor treatment and, as an alternative, use bypass treatment (eg, recombinant factor VIIa or factor VIII inhibitor bypass activity)...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222271/optimizing-therapy-for-mantle-cell-lymphoma
#2
REVIEW
Peter Martin
Most people with mantle cell lymphoma (MCL) present with diffuse adenopathy and benefit from early initiation of rituximab and high-dose cytarabine- or bendamustine-based therapies. Some patients, however, present with primarily nonnodal disease that can follow either an indolent or a rapidly progressive, treatment-resistant clinical course. Rarely, patients present with explosive disease that can be challenging to manage and often involves the central nervous system. New agents with improved therapeutic indices facilitate treatment while maintaining quality of life, but also present new complications at the time of treatment failure...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222096/aerobic-transformation-of-2-4-dinitrotoluene-by-escherichia-coli-and-its-implications-for-the-detection-of-trace-explosives
#3
Benjamin Shemer, Sharon Yagur-Kroll, Carina Hazan, Shimshon Belkin
DNT (2,4-dinitrotoluene), a volatile impurity in military grade TNT-based explosives, is a potential tracer for the detection of buried landmines and other explosive devices. We have previously described an Escherichia coli bioreporter strain engineered to detect traces of DNT, and have demonstrated that the yqjF gene promoter, the sensing element of this bioreporter, is induced not by DNT but by at least one of its transformation products. In the present study we have characterized the initial stages of DNT biotransformation in E...
December 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29219303/explosive-reaction-for-barium-niobium-perovskite-oxynitride
#4
Jin Odahara, Akira Miura, Nataly Carolina Rosero-Navarro, Kiyoharu Tadanaga
An intense exothermic and explosive reaction between Ba(OH)2, NbCl5, and NaNH2 produced barium niobium perovskite oxynitride in seconds. The addition of hexane reduced the risk of explosion during mixing of the starting materials, and subsequent heat treatment at 498 K in hexane allowed control of this exothermic reaction, leading to formation of the perovskite oxynitride with fewer impurities. The synthesis of barium tantalum perovskite oxynitride under similar reaction conditions was successful.
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29218989/redox-tag-processes-intramolecular-electron-transfer-and-its-broad-relationship-to-redox-reactions-in-general
#5
Yohei Okada, Kazuhiro Chiba
Explosive growth in the use of open shell reactivity, including neutral radicals and radical ions, in the field of synthetic organic chemistry has been observed in the past decade, particularly since the advent of ruthenium complexes in 2008. These complexes generally induce single-electron transfer (SET) processes via visible-light absorption. Additionally, recent significant advancements in organic electrochemistry involving SET processes to provide open shell reactivity offer a complementary method to traditional polarity-driven reactions described by two-electron transfer processes...
December 8, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/29218890/democratizing-data-science-through-data-science-training
#6
John Darrell Van Horn, Lily Fierro, Jeana Kamdar, Jonathan Gordon, Crystal Stewart, Avnish Bhattrai, Sumiko Abe, Xiaoxiao Lei, Caroline O'Driscoll, Aakanchha Sinha, Priyambada Jain, Gully Burns, Kristina Lerman, José Luis Ambite
The biomedical sciences have experienced an explosion of data which promises to overwhelm many current practitioners. Without easy access to data science training resources, biomedical researchers may find themselves unable to wrangle their own datasets. In 2014, to address the challenges posed such a data onslaught, the National Institutes of Health (NIH) launched the Big Data to Knowledge (BD2K) initiative. To this end, the BD2K Training Coordinating Center (TCC; bigdatau.org) was funded to facilitate both in-person and online learning, and open up the concepts of data science to the widest possible audience...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218562/hybrid-applications-of-solution-scattering-to-aid-structural-biology
#7
Alexander V Grishaev
Biomolecular applications of solution X-ray and neutron scattering (SAXS and SANS, respectively) started in late 1960s - early 1970s but were relatively limited in their ability to provide a detailed structural picture and lagged behind what became the two primary methods of experimental structural biology - X-ray crystallography and NMR. However, improvements in both data analysis and instrumentation led to an explosive growth in the number of studies that used small-angle scattering (SAS) for investigation of macromolecular structure, often in combination with other biophysical techniques...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29216194/partitioning-no-take-marine-reserve-ntmr-and-benthic-habitat-effects-on-density-of-small-and-large-bodied-tropical-wrasses
#8
Garry R Russ, Jake R Lowe, Justin R Rizzari, Brock J Bergseth, Angel C Alcala
No-take marine reserves (NTMRs) are increasingly implemented for fisheries management and biodiversity conservation. Yet, assessing NTMR effectiveness depends on partitioning the effects of NTMR protection and benthic habitat on protected species. Such partitioning is often difficult, since most studies lack well-designed sampling programs (i.e. Before-After-Control-Impact-Pair designs) spanning long-term time scales. Spanning 31 years, this study quantifies the effects of NTMR protection and changes to benthic habitat on the density of tropical wrasses (F...
2017: PloS One
https://www.readbyqxmd.com/read/29216079/theoretical-investigation-of-a-five-band-terahertz-absorber-based-on-an-asymmetric-split-ring-resonator
#9
Tianhua Meng, Dan Hu, Hongyan Wang, Xiwei Zhang, Zhenjie Tang
A simple five-band terahertz metamaterial perfect absorber, composed of an asymmetric double-gap square split ring and a metallic ground plate spaced by a thin polyimide dielectric layer, is proposed and theoretically investigated. The results show that it can perform absorption peaks at five resonant frequencies whose peaks average 98.85%. The perfect absorption is mainly attributed to the combined effect of LC, dipole, and surface response of the structure. Compared to previously reported multiband absorbers, our design only has a single and compact structure, which can drastically simplify the design and fabrication process...
December 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29212136/explosive-detection-using-a-novel-dielectric-barrier-discharge-ionisation-source-for-mass-spectrometry
#10
Carl Fletcher, Richard Sleeman, John Luke, Peter Luke, James W Bradley
The detection of explosives is of great importance, as is the need for sensitive, reliable techniques that require little or no sample preparation and short run times for high throughput analysis. In this work, a novel ionisation source is presented based on a dielectric barrier discharge (DBD). This not only effects desorption and ionisation, but also forms an ionic wind, providing mass transportation of ions towards the mass spectrometer. Furthermore, the design incorporates two asymmetric alumina sheets, each containing three DBDs, so that a large surface area can be analysed...
December 6, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29211835/massive-iatrogenic-outbreak-of-human-immunodeficiency-virus-type-1-in-rural-cambodia-2014-2015
#11
François Rouet, Janin Nouhin, Du-Ping Zheng, Benjamin Roche, Allison Black, Sophearot Prak, Marie Leoz, Catherine Gaudy-Graffin, Laurent Ferradini, Chandara Mom, Sovatha Mam, Charlotte Gautier, Gérard Lesage, Sreymom Ken, Kerya Phon, Alexandra Kerleguer, Chunfu Yang, William Killam, Masami Fujita, Chhivun Mean, Didier Fontenille, Francis Barin, Jean-Christophe Plantier, Trevor Bedford, Artur Ramos, Vonthanak Saphonn
Background: In 2014-2015, 242 individuals aged 2-89 were newly HIV-1 diagnosed in Roka, a rural commune in Cambodia. A case-control study attributed the outbreak to unsafe injections. We aimed to reconstruct the likely transmission history of the outbreak. Methods: We assessed in 209 (86.4%) HIV-infected cases the presence of hepatitis C and B viruses (HCV, HBV). We identified recent infections using antibody (Ab) avidity testing for HIV and HCV, and HBcIgM Ab for HBV...
December 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29211773/design-of-a-novel-instrument-for-active-neutron-interrogation-of-artillery-shells
#12
Camille Bélanger-Champagne, Hannes Vainionpää, Pauli Peura, Harri Toivonen, Paula Eerola, Peter Dendooven
The most common explosives can be uniquely identified by measuring the elemental H/N ratio with a precision better than 10%. Monte Carlo simulations were used to design two variants of a new prompt gamma neutron activation instrument that can achieve this precision. The instrument features an intense pulsed neutron generator with precise timing. Measuring the hydrogen peak from the target explosive is especially challenging because the instrument itself contains hydrogen, which is needed for neutron moderation and shielding...
2017: PloS One
https://www.readbyqxmd.com/read/29209433/novel-insights-into-epigenetic-drivers-of-oropharyngeal-squamous-cell-carcinoma-role-of-hpv-and-lifestyle-factors
#13
REVIEW
Paolo Boscolo-Rizzo, Carlo Furlan, Valentina Lupato, Jerry Polesel, Elisabetta Fratta
In the last years, the explosion of high throughput sequencing technologies has enabled epigenome-wide analyses, allowing a more comprehensive overview of the oropharyngeal squamous cell carcinoma (OPSCC) epigenetic landscape. In this setting, the cellular pathways contributing to the neoplastic phenotype, including cell cycle regulation, cell signaling, DNA repair, and apoptosis have been demonstrated to be potential targets of epigenetic alterations in OPSCC. Of note, it has becoming increasingly clear that HPV infection and OPSCC lifestyle risk factors differently drive the epigenetic machinery in cancer cells...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29209122/advances-in-endoscopic-balloon-therapy-for-weight-loss-and-its-limitations
#14
EDITORIAL
Dinesh Vyas, Kaivalya Deshpande, Yagnik Pandya
The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera™ Intragastric Balloon System (Apollo Endosurgery Inc, Austin, TX, United States), the ReShape® Integrated Dual Balloon System (ReShape Medical, Inc...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29206043/high-throughput-computational-screening-of-multivariate-metal-organic-frameworks-mtv-mofs-for-co2-capture
#15
Song Li, Yongchul G Chung, Cory M Simon, Randall Q Snurr
Multivariate metal-organic frameworks (MTV-MOFs) contain multiple linker types within a single structure. Arrangements of linkers containing different functional groups confer structural diversity and surface heterogeneity and result in a combinatorial explosion in the number of possible structures. In this work, we carried out a high-throughput computational screening of a large number of computer-generated MTV-MOFs to assess their CO2 capture properties using grand canonical Monte Carlo simulations. The results demonstrate that functionalization enhances CO2 capture performance of MTV-MOFs when compared to their parent (unfunctionalized) counterparts, and the pore size plays a dominant role in determining the CO2 adsorption capabilities of MTV-MOFs irrespective of the combinations of the three functional groups (-F, -NH2 and -OCH3) that we investigated...
December 5, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29204726/psychopathology-and-associated-risk-factors-among-forcibly-displaced-syrian-children-and-adolescents
#16
Vahdet Gormez, Hale Nur Kılıç, A Cahid Orengul, Merve Nursoy Demir, Şeyma Demirlikan, Sibel Demirbaş, Betül Babacan, Kerem Kınık, Bengi Semerci
More than half of the 2.7 million registered Syrian refugees in Turkey are under 18 years of age. This study investigates prevalence of psychopathology and associated risk factors in refugee children in Turkey. Of a total of 218 children aged 9-15 years, 56.2% lost someone important to them, 55.1% saw dead or wounded people, 70.4% witnessed explosions or gun battles, 42.5% witnessed people being tortured and 25.6% personally experienced cruelty/torture during war. Prevalence of PTSD was 18.3% and that of anxiety-related disorders were as high as 69...
December 4, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29203840/enhancement-of-eruption-explosivity-by-heterogeneous-bubble-nucleation-triggered-by-magma-mingling
#17
Joali Paredes-Mariño, Katherine J Dobson, Gianluigi Ortenzi, Ulrich Kueppers, Daniele Morgavi, Maurizio Petrelli, Kai-Uwe Hess, Kathrin Laeger, Massimiliano Porreca, Adriano Pimentel, Diego Perugini
We present new evidence that shows magma mingling can be a key process during highly explosive eruptions. Using fractal analysis of the size distribution of trachybasaltic fragments found on the inner walls of bubbles in trachytic pumices, we show that the more mafic component underwent fracturing during quenching against the trachyte. We propose a new mechanism for how this magmatic interaction at depth triggered rapid heterogeneous bubble nucleation and growth and could have enhanced eruption explosivity...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203719/an-ediacaran-pre-placozoan-alternative-to-the-pre-sponge-route-towards-the-cambrian-explosion-of-animal-life-a-comment-on-cavalier-smith-2017
#18
Suzanne C Dufour, Duncan McIlroy
No abstract text is available yet for this article.
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29203201/combat-related-acetabular-fractures-outcomes-of-open-versus-closed-injuries
#19
Richard L Purcell, Michael A Donohue, Sameer K Saxena, Wade T Gordon, Louis L Lewandowski
INTRODUCTION: Since the onset of the Global War on Terror close to 50,000 United States service members have been injured in combat, many of these injuries would have previously been fatal. Among these injuries, open acetabular fractures are at an increased number due to the high percentage of penetrating injuries such as high velocity gunshot wounds and blast injuries. These injuries lead to a greater degree of contamination, and more severe associated injuries. There is a significantly smaller proportion of the classic blunt trauma mechanism typically seen in civilian trauma...
December 1, 2017: Injury
https://www.readbyqxmd.com/read/29202784/sprint-and-jump-performance-in-elite-male-soccer-players-following-a-10-week-nordic-hamstring-exercise-protocol-a-randomised-pilot-study
#20
K Krommes, J Petersen, M B Nielsen, P Aagaard, P Hölmich, K Thorborg
OBJECTIVE: The preseason Nordic Hamstring Protocol (NHP) reduces hamstring strain injuries in football players. Despite persisting injury rates, elite clubs are reluctant to apply the NHP often over concerns of negative impacts on performance. This pilot study investigated if sprint or jump-performance outcomes tended to increase or decrease following implementation of the NHP in elite male soccer-players. RESULTS: Nineteen male soccer players from the Danish 1st division were randomised to perform NHP (27 sessions) during pre-season, or to control group (CG)...
December 4, 2017: BMC Research Notes
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