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https://www.readbyqxmd.com/read/29470746/nitinol-stents-in-the-femoropopliteal-artery-a-mechanical-perspective-on-material-design-and-performance
#1
REVIEW
Kaspars Maleckis, Eric Anttila, Paul Aylward, William Poulson, Anastasia Desyatova, Jason MacTaggart, Alexey Kamenskiy
Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement...
February 22, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29469950/stabilization-of-the-pentazolate-anion-in-three-anhydrous-and-metal-free-energetic-salts-n5-2dabtt2-n5-gu-and-n5-oxahy
#2
Yuangang Xu, Qiuhan Lin, Pengcheng Wang, Ming Lu
According to previous reports, metal cations or water molecules are necessary for the stabilization of pentazolate anion (cyclo-N5-) at ambient temperature and pressure. Seeking a new existence way of N5- is a big challenge. In this work, three anhydrous, metal-free energetic salts based on pentazole anion (cyclo-N5-) 3,9-diamino-6,7-dihydro-5H-bis([1,2,4]triazolo)[4,3-e:3',4'-g][1,2,4,5] tetrazepine-2,10-diium, N-carbamoylguanidinium, and oxalohydrazinium pentazolate were synthesized and isolated. All of the new salts were characterized by elemental analysis, IR spectroscopy, 1H, 13C, and (in some cases) 15N NMR spectroscopy, thermal analysis (TGA and DSC), and single-crystal X-ray diffraction...
February 22, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29469244/longitudinal-associations-of-explosive-and-adventurous-temperament-profiles-with-character-development-the-modifying-effects-of-social-support-and-attachment
#3
Aino I L Saarinen, Tom H Rosenström, Christian A Hakulinen, Claude Robert Cloninger, Mirka H M Hintsanen, Laura M Pulkki-Råback, Terho Lehtimäki, Olli T Raitakari, Liisa Keltikangas-Järvinen
OBJECTIVE: The aim of this study was to examine (a) whether adventurous and explosive temperament profiles (presumed precursors of antisocial and borderline personality) are associated with character traits over a 15-year follow-up and (b) whether social support and attachment security modify the relationship between temperament profiles and character development. METHODS: 2,028 subjects of the Young Finns study completed the Temperament and Character Inventory, the Multidimensional Scale of Perceived Social Support, and the Relationship Questionnaire at 3 assessment points between 1997 and 2012...
February 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29469097/a-surge-of-light-at-the-birth-of-a-supernova
#4
M C Bersten, G Folatelli, F García, S D Van Dyk, O G Benvenuto, M Orellana, V Buso, J L Sánchez, M Tanaka, K Maeda, A V Filippenko, W Zheng, T G Brink, S B Cenko, T de Jaeger, S Kumar, T J Moriya, K Nomoto, D A Perley, I Shivvers, N Smith
It is difficult to establish the properties of massive stars that explode as supernovae. The electromagnetic emission during the first minutes to hours after the emergence of the shock from the stellar surface conveys important information about the final evolution and structure of the exploding star. However, the unpredictable nature of supernova events hinders the detection of this brief initial phase. Here we report the serendipitous discovery of a newly born, normal type IIb supernova (SN 2016gkg), which reveals a rapid brightening at optical wavelengths of about 40 magnitudes per day...
February 21, 2018: Nature
https://www.readbyqxmd.com/read/29467794/detection-of-potential-problematic-cytb-gene-sequences-of-fishes-in-genbank
#5
Xiaobing Li, Xuejuan Shen, Xiao Chen, Dan Xiang, Robert W Murphy, Yongyi Shen
Fishes are, by far, the most diverse group of vertebrates. Their classification relies heavily on morphology. In practice, the correct morphological identification of species often depends on personal experience because many species vary in their body shape, color and other external characters. Thus, the identification of a species may be prone to errors. Due to the rapid development of molecular biology, the number of sequences of fishes deposited in GenBank has grown explosively. These published data likely contain errors owing to invalid or incorrectly identified species...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29464739/trigger-bond-analysis-of-nitroaromatic-energetic-materials-using-wiberg-bond-indices
#6
Ashley L Shoaf, Craig A Bayse
The identification of trigger bonds, bonds that break to initiate explosive decomposition, using computational methods could help direct the development of novel, "green" and efficient high energy density materials (HEDMs). Comparing bond densities in energetic materials to reference molecules using Wiberg bond indices (WBIs) provides a relative scale for bond activation (%ΔWBIs) to assign trigger bonds in a set of 63 nitroaromatic conventional energetic molecules. Intramolecular hydrogen bonding interactions enhance contributions of resonance structures that strengthen, or deactivate, the CNO2 trigger bonds and reduce the sensitivity of nitroaniline-based HEDMs...
February 21, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29464533/photo-induced-toxicity-in-early-life-stage-fiddler-crab-uca-longisignalis-following-exposure-to-deepwater-horizon-oil
#7
Leigh M Damare, Kristin N Bridges, Matthew M Alloy, Thomas E Curran, Brianne K Soulen, Heather P Forth, Claire R Lay, Jeffrey M Morris, James A Stoeckel, Aaron P Roberts
The 2010 explosion of the Deepwater Horizon (DWH) oil rig led to the release of millions of barrels of oil in the Gulf of Mexico. Oil in aquatic ecosystems exerts toxicity through multiple mechanisms, including photo-induced toxicity following co-exposure with UV radiation. The timing and location of the spill coincided with both fiddler crab reproduction and peak yearly UV intensities, putting early life stage fiddler crabs at risk of injury due to photo-induced toxicity. The present study assessed sensitivity of fiddler crab larvae to photo-induced toxicity during co-exposure to a range of environmentally relevant dilutions of high-energy water accommodated fractions of DWH oil, and either <10, 50, or 100% ambient sunlight, achieved with filters that allowed for variable UV penetration...
February 20, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29464367/inalambric-biofeedback-devices-to-analyze-strength-manifestation-in-military-population
#8
Rosa Delgado-Moreno, José Juan Robles-Pérez, Susana Aznar, Vicente Javier Clemente-Suarez
The study of the effect of stress on both combatants physiological and anatomical systems have been poor studied in the specific literature. The present research aimed to study the effect of combat stress in strength manifestations of leg flexor-extensor muscles and the anaerobic metabolism of soldiers. Before and after asymmetrical combat simulation were analyzed parameters of blood lactate concentration, explosive leg strength manifestation and contractile capacity of leg muscle in 186 professional soldiers...
February 20, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29459706/gene-based-predictive-models-of-trophic-modes-suggest-asgard-archaea-are-not-phagocytotic
#9
John A Burns, Alexandros A Pittis, Eunsoo Kim
With the current explosion of genomic data, there is a greater need to draw inference on phenotypic information based on DNA sequence alone. We considered complete genomes from 35 diverse eukaryotic lineages, and discovered sets of proteins predictive of trophic mode, including a set of 485 proteins that are enriched among phagocytotic eukaryotes (organisms that internalize large particles). Our model is also predictive of other aspects of trophic mode, including photosynthesis and the ability to synthesize a set of organic compounds needed for growth (prototrophy for those molecules)...
February 19, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29457232/tackling-obesity-and-disease-the-culprit-is-sugar-the-response-is-legal-regulation
#10
Lawrence O Gostin
It is staggering to observe the new normal in America: 37.9 percent of adults are obese, and 70.7 percent are either obese or overweight. One out of every five minors is obese. The real tragedy, of course, is the disability, suffering, and early death that devastates families and communities. But all of society pays, with the annual medical cost estimated at $147 billion. The causal pathways are complex, but if we drill down, sugar is a deeply consequential pathway to obesity, and the single greatest dietary source is sugar-sweetened beverages (SSBs)...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29456279/uncertainty-footprint-visualization-of-nonuniform-behavior-of-iterative-algorithms-applied-to-4d-cell-tracking
#11
Y Wan, C Hansen
Research on microscopy data from developing biological samples usually requires tracking individual cells over time. When cells are three-dimensionally and densely packed in a time-dependent scan of volumes, tracking results can become unreliable and uncertain. Not only are cell segmentation results often inaccurate to start with, but it also lacks a simple method to evaluate the tracking outcome. Previous cell tracking methods have been validated against benchmark data from real scans or artificial data, whose ground truth results are established by manual work or simulation...
June 2017: Computer Graphics Forum: Journal of the European Association for Computer Graphics
https://www.readbyqxmd.com/read/29456254/far-ultraviolet-spectroscopy-of-old-novae-ii-rr-pic-v533-her-and-di-lac
#12
Edward M Sion, Patrick Godon, Liam Jones
The old novae V533 Her (Nova Her 1963), DI Lac (Nova Lac 1910), and RR Pic (Nova Pic 1891) are in (or near) their quiescent stage, following their nova explosions, and continue to accrete at a high rate in the aftermath of their explosions. They exhibit continua that are steeply rising into the FUV, as well as absorption lines and emission lines of uncertain origin. All three have Far Ultraviolet Spectroscopic Explorer ( FUSE ) spectra that offer not only higher spectral resolution but also wavelength coverage extending down to the Lyman Limit...
March 2017: Astronomical Journal
https://www.readbyqxmd.com/read/29456081/lysozyme-counteracts-%C3%AE-lactam-antibiotics-by-promoting-the-emergence-of-l-form-bacteria
#13
Yoshikazu Kawai, Katarzyna Mickiewicz, Jeff Errington
β-lactam antibiotics inhibit bacterial cell wall assembly and, under classical microbiological culture conditions that are generally hypotonic, induce explosive cell death. Here, we show that under more physiological, osmoprotective conditions, for various Gram-positive bacteria, lysis is delayed or abolished, apparently because inhibition of class A penicillin-binding protein leads to a block in autolytic activity. Although these cells still then die by other mechanisms, exogenous lytic enzymes, such as lysozyme, can rescue viability by enabling the escape of cell wall-deficient "L-form" bacteria...
January 31, 2018: Cell
https://www.readbyqxmd.com/read/29455060/major-depressive-disorder-and-depressive-symptoms-in-intermittent-explosive-disorder
#14
Gustavo C Medeiros, Liliana Seger, Jon E Grant, Hermano Tavares
It is estimated that between 1.7 and 2.6 million people have had intermittent explosive disorder (IED) during their life in the United States alone. Co-occurring psychiatric disorders are very common in IED, being major depressive disorder arguably the most common. The objective of this study was to examine the clinical correlates of IED and depressive manifestations in 74 treatment-seeking subjects. After controlling for confounders, there were associations between major depressive disorder and severity of depressive symptoms, and (a) higher assault scores, (b) more severe hostile behavior and (c) worse social adjustment...
February 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29454856/nucleosidic-dna-demethylating-epigenetic-drugs-a-comprehensive-review-from-discovery-to-clinic
#15
REVIEW
Khushboo Agrawal, Viswanath Das, Pankhuri Vyas, Marián Hajdúch
DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic silencing of cancer-related genes. Since the relationship between aberrant DNA methylation and cancer has been understood, there has been an explosion of research at developing anti-cancer therapies that work by inhibiting DNA methylation. From the discovery of first DNA hypomethylating drugs in the 1980s to recently discovered second generation pro-drugs, exceedingly large number of studies have been published that describe the DNA hypomethylation-based anti-neoplastic action of these drugs in various stages of the pre-clinical investigation and advanced stages of clinical development...
February 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29452562/deciphering-the-sunshine-act-transparency-regulation-and-financial-conflicts-in-health-care
#16
Richard S Saver
The Physician Payments Sunshine Act ("Sunshine Act"), enacted to address financial conflicts in health care, is the first comprehensive federal legislation mandating public reporting of payments between drug companies, device manufacturers, and medicine. This article analyzes the Sunshine Act's uneven record, exploring how the law serves as an intriguing example of the uncertain case for transparency regulation in health care. The Sunshine Act's bumpy rollout demonstrates that commanding transparency through legislation can be arduous because of considerable implementation challenges...
November 2017: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/29451115/understanding-the-complexities-of-food-safety-using-a-one-health-approach
#17
Kalmia E Kniel, Deepak Kumar, Siddhartha Thakur
The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals...
February 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29450780/systematic-reviews-and-meta-analysis-in-rhinosinusitis-a-critical-review-of-the-reviews
#18
REVIEW
Abigail Walker, Claire Hopkins
PURPOSE OF REVIEW: There has been an explosion in the number of published systematic reviews on chronic rhinosinusitis in the last decade. RECENT FINDINGS: While the aim of these reviews in facilitating evidence-based practice is laudable, poor quality reviews may contain significant bias that can mislead a non-discerning reader. Attention therefore must be given to review methodology before implanting findings. Organisations such as the Cochrane Collaboration promote high-quality reviews, but are limited in chronic sinus disease by heterogeneous outcomes and a paucity of randomised trials...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29449040/xenon-adsorption-on-geological-media-and-implications-for-radionuclide-signatures
#19
M J Paul, S R Biegalski, D A Haas, H Jiang, H Daigle, J D Lowrey
The detection of radioactive noble gases is a primary technology for verifying compliance with the pending Comprehensive Nuclear-Test-Ban Treaty. A fundamental challenge in applying this technology for detecting underground nuclear explosions is estimating the timing and magnitude of the radionuclide signatures. While the primary mechanism for transport is advective transport, either through barometric pumping or thermally driven advection, diffusive transport in the surrounding matrix also plays a secondary role...
February 12, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29447407/the-feasibility-of-venovenous-ecmo-at-role-2-facilities-in-austere-military-environments
#20
Mohamed A T Mohamed, Tareq Maraqa, Matthew D Bacchetta, Michael McShane, Kenneth L Wilson
Introduction: Venovenous extracorporeal membrane oxygenation (VV-ECMO) has been gaining use to bridge the recovery from acute respiratory distress syndrome (ARDS) refractory to conventional treatment. However, these interventions are often limited to higher echelons of military care. We present a case of lung salvage from severe ARDS in an Afghani soldier with VV-ECMO at a Role-2 (R2) facility in an austere military environment in Afghanistan. Case: A 25-year-old Afghani soldier presented to an R2 facility with blast lung injury and multiple penetrating injuries following an explosion...
February 13, 2018: Military Medicine
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