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https://www.readbyqxmd.com/read/29036667/disnor-a-disease-network-open-resource
#1
Prisca Lo Surdo, Alberto Calderone, Marta Iannuccelli, Luana Licata, Daniele Peluso, Luisa Castagnoli, Gianni Cesareni, Livia Perfetto
DISNOR is a new resource that aims at exploiting the explosion of data on the identification of disease-associated genes to assemble inferred disease pathways. This may help dissecting the signaling events whose disruption causes the pathological phenotypes and may contribute to build a platform for precision medicine. To this end we combine the gene-disease association (GDA) data annotated in the DisGeNET resource with a new curation effort aimed at populating the SIGNOR database with causal interactions related to disease genes with the highest possible coverage...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036535/ploc-manimal-predict-subcellular-localization-of-animal-proteins-with-both-single-and-multiple-sites
#2
Xiang Cheng, Shu-Guang Zhao, Wei-Zhong Lin, Xuan Xiao, Kuo-Chen Chou
Motivation: Cells are deemed the basic unit of life. However, many important functions of cells as well as their growth and reproduction are performed via the protein molecules located at their different organelles or locations. Facing explosive growth of protein sequences, we are challenged to develop fast and effective method to annotate their subcellular localization. However, this is by no means an easy task. Particularly, mounting evidences have indicated proteins have multi-label feature meaning that they may simultaneously exist at, or move between, two or more different subcellular location sites...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29031831/large-scale-retrieval-for-medical-image-analytics-a-comprehensive-review
#3
REVIEW
Zhongyu Li, Xiaofan Zhang, Henning Müller, Shaoting Zhang
Over the past decades, medical image analytics was greatly facilitated by the explosion of digital imaging techniques, where huge amounts of medical images were produced with ever-increasing quality and diversity. However, conventional methods for analyzing medical images have achieved limited success, as they are not capable to tackle the huge amount of image data. In this paper, we review state-of-the-art approaches for large-scale medical image analysis, which are mainly based on recent advances in computer vision, machine learning and information retrieval...
October 2, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29031410/harnessing-gut-microbes-for-mental-health-getting-from-here-to-there
#4
REVIEW
Annadora J Bruce-Keller, J Michael Salbaum, Hans-Rudolf Berthoud
There has been an explosion of interest in the study of microorganisms inhabiting the gastrointestinal tract (gut microbiota) and their impact on host health and physiology. Accumulating data suggest that altered communication between gut microbiota and host systems could participate in disorders such as obesity, diabetes mellitus, and autoimmune disorders as well as neuropsychiatric disorders, including autism, anxiety, and major depressive disorders. The conceptual development of the microbiome-gut-brain axis has facilitated understanding of the complex and bidirectional networks between gastrointestinal microbiota and their host, highlighting potential mechanisms through which this environment influences central nervous system physiology...
August 30, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29030696/superposed-epoch-analysis-of-physiological-fluctuations-possible-space-weather-connections
#5
James Wanliss, Germaine Cornélissen, Franz Halberg, Denzel Brown, Brien Washington
There is a strong connection between space weather and fluctuations in technological systems. Some studies also suggest a statistical connection between space weather and subsequent fluctuations in the physiology of living creatures. This connection, however, has remained controversial and difficult to demonstrate. Here we present support for a response of human physiology to forcing from the explosive onset of the largest of space weather events-space storms. We consider a case study with over 16 years of high temporal resolution measurements of human blood pressure (systolic, diastolic) and heart rate variability to search for associations with space weather...
October 13, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29030450/effect-of-concussion-and-blast-exposure-on-symptoms-after-military-deployment
#6
Jack W Tsao, Lauren A Stentz, Minoo Rouhanian, Robin S Howard, Briana N Perry, F Jay Haran, Paul F Pasquina, Mikias Wolde, Carolyn E Taylor, Radhames Lizardo, Scott Liu, Eusebio Flores, Alia H Creason, Katalina Sher
OBJECTIVE: To examine whether blast exposure alone and blast-associated concussion result in similar neurologic and mental health symptoms. METHODS: A 14-item questionnaire was administered to male US Marines on their return from deployment in Iraq and/or Afghanistan. RESULTS: A total of 2,612 Marines (median age 22 years) completed the survey. Of those, 2,320 (88.9%) reported exposure to ≥1 blast during their current and/or prior deployments...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29029409/metabolic-characterization-and-pathway-analysis-of-berberine-protects-against-prostate-cancer
#7
Xianna Li, Aihua Zhang, Hui Sun, Zhidong Liu, Tianlei Zhang, Shi Qiu, Liang Liu, Xijun Wang
Recent explosion of biological data brings a great challenge for the traditional methods. With increasing scale of large data sets, much advanced tools are required for the depth interpretation problems. As a rapid-developing technology, metabolomics can provide a useful method to discover the pathogenesis of diseases. This study was explored the dynamic changes of metabolic profiling in cells model and Balb/C nude-mouse model of prostate cancer, to clarify the therapeutic mechanism of berberine, as a case study...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029343/an-evaluation-of-different-partitioning-strategies-for-bayesian-estimation-of-species-divergence-times
#8
Konstantinos Angelis, Sandra Álvarez-Carretero, Mario Dos Reis, Ziheng Yang
The explosive growth of molecular sequence data has made it possible to estimate species divergence times under relaxed-clock models using genome-scale data sets with many gene loci. In order to improve both model realism and to best extract information about relative divergence times in the sequence data, it is important to account for the heterogeneity in the evolutionary process across genes or genomic regions. Partitioning is a commonly used approach to achieve those goals. We group sites that have similar evolutionary characteristics into the same partition and those with different characteristics into different partitions, and then use different models or different values of model parameters for different partitions to account for the among-partition heterogeneity...
July 4, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29029156/detailed-transmission-network-analysis-of-a-large-opiate-driven-outbreak-of-hiv-infection-in-the-united-states
#9
Ellsworth M Campbell, Hongwei Jia, Anupama Shankar, Debra Hanson, Wei Luo, Silvina Masciotra, S Michele Owen, Alexandra M Oster, Romeo R Galang, Michael W Spiller, Sara J Blosser, Erika Chapman, Jeremy C Roseberry, Jessica Gentry, Pamela Pontones, Joan Duwve, Paula Peyrani, Ron M Kagan, Jeannette M Whitcomb, Philip J Peters, Walid Heneine, John T Brooks, William M Switzer
In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a diagnosis of HIV infection. We report results of new approaches to analyzing epidemiologic and laboratory data to understand transmission during this outbreak. HIV genetic distances were calculated using the polymerase region. Networks were generated using data about reported high-risk contacts, viral genetic similarity, and their most parsimonious combinations...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028403/laser-ion-mobility-spectrometry-in-the-detection-of-ultra-low-quantities-of-explosives
#10
A E Akmalov, A A Chistyakov, G E Kotkovskii, I L Martynov, E M Spitsin
The paper presents the results of research and development of ion mobility spectrometer with laser ion sources for detecting ultra-low quantities of explosives in air. Particular attention is paid to the mechanisms of the formation of negative ions. It is shown that laser ionization with respect to ion mobility spectrometry provides an increase of sensitivity and selectivity of detection. The ion mobility spectra of the most common nitro explosives are investigated. The detection threshold for laser ion mobility spectrometer was reached at the level of 10(-14 )g/cm(3) (for trinitrotoluene)...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028396/laser-stimulated-desorption-of-organic-molecules-from-surfaces-as-a-method-of-increasing-the-efficiency-of-ion-mobility-spectrometry-analysis
#11
Artem E Akmalov, Alexander A Chistyakov, Gennadii E Kotkovskii
Application of laser-induced desorption was investigated as a method of increasing the efficiency of gas phase analyzers on principles of field asymmetric ion mobility spectrometry. Mass spectrometric data of investigations of laser desorption of pentaerythritoltetranitrate molecules and cyclotetramethylenetetranitramine molecules from quartz substrate under vacuum were obtained. Laser sources a Nd(3+):YAG with nanosecond pulse duration (λ = 532 nm) and a continuous wave diode laser (λ = 440 nm) were used...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028394/active-sampling-system-for-gas-phase-analyzers
#12
Artem E Akmalov, Alexander A Chistyakov, Olga I Dubkova, Gennadii E Kotkovskii, Alexei V Sychev
The approaches for increasing a contact-free sampling distance up to 40 cm for a field asymmetric ion mobility spectrometer were investigated and implemented by use both the vortex flow made by a rotating impeller and the laser desorption of traces of low volatile explosives. The sampling device for a laser-based field asymmetric ion mobility spectrometer including a high-speed rotating impeller was designed and built with help of computer simulation of vortex and analytical flows. The dependence of a signal of trinitrotoluene vapors on a rotational speed of an impeller was obtained...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29027665/impact-of-digital-technologies-on-novel-endpoint-capture-in-clinical-trials
#13
Ieuan Clay
Digital technologies have been successfully deployed in clinical settings for many years, yet recent advances in hardware and analytic capabilities have driven an explosion in interest over the potential of digital medicine to change how drugs are developed, centering on how we interact with patients, treat patients, and capture information about patients.
October 13, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29024509/adding-a-new-separation-dimension-to-ms-and-lc-ms-what-is-the-utility-of-ion-mobility-spectrometry
#14
Valentina D'Atri, Tim Causon, Oscar Hernandez-Alba, Aline Mutabazi, Jean-Luc Veuthey, Sarah Cianferani, Davy Guillarme
Ion mobility spectrometry is an analytical technique known for more than 100 years, which entails separating ions in the gas phase based on their size, shape and charge. While ion mobility spectrometry alone can be useful for some applications (mostly security analysis for detecting certain classes of narcotics and explosives), it becomes even more powerful in combination with mass spectrometry and high-performance liquid chromatography. Indeed, the limited resolving power of ion mobility spectrometry alone can be tackled when combining this analytical strategy with mass spectrometry or liquid chromatography with mass spectrometry...
October 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29024395/deep-eutectic-solvent-based-magnetic-nanofluid-in-the-development-of-stir-bar-sorptive-dispersive-microextraction-an-efficient-hyphenated-sample-preparation-for-ultra-trace-nitroaromatic-explosives-extraction-in-wastewater
#15
Ali Reza Zarei, Maryam Nedaei, Sohrab Ali Ghorbanian
A deep eutectic solvent based magnetic nanofluid was coupled with stir bar sorptive dispersive microextraction as a hyphenated sample preparation technique. The neodymium core magnetic stir bar was coated physically with nanofluid of magnetic carbon nanotube nanocomposites and deep eutectic solvents. The prepared nanofluid has magnetic and strong sorbing properties and is compatible with gas chromatography. In this nanofluid, the deep eutectic solvent acts simultaneously as both carrier and stabilizer for magnetic nanotubes...
October 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29023322/effects-of-two-different-training-periodization-models-on-physical-and-physiological-aspects-of-elite-female-team-handball-players
#16
Carmen Manchado, Juan M Cortell-Tormo, Juan Tortosa-Martínez
Manchado, C, Cortell-Tormo, JM, and Tortosa-Martínez, J. Effects of two different training periodization models on physical and physiological aspects of elite female team handball players. J Strength Cond Res XX(X): 000-000, 2017-This study was undertaken to compare training-induced changes in selected physiological and physical team handball performance factors after 2 training periodization models: traditional vs. block periodization (BP). Eleven female team handball players who played over 2 consecutive seasons for a Spanish first league team were assessed twice per season during a training cycle...
October 10, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29022591/chemistry-explosive-moments-in-the-laboratory
#17
Mark Peplow
No abstract text is available yet for this article.
October 11, 2017: Nature
https://www.readbyqxmd.com/read/29021718/epidemiology-and-outcome-of-2-590-burned-patients-in-northwest-iran
#18
S N Hosseini, V Rashtchi, K Kamali, M H Moghimi
Burns are calamities with considerable morbidity and mortality rates. We attempted to examine the epidemiology of burns in Zanjan city, in northwest Iran, by a systematic study of existing information. The medical files of 2,590 thermal burn patients treated in our hospital in Zanjan city, Iran, from December 2010 to November 2016 were studied. Patient information, including age, sex, burn degree, season, cause of burn, hospital stay and treatment results were analyzed. About 65% of the patients were male (n=1691)...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29021169/punctuated-invasion-of-water-ice-snow-and-terrestrial-ecozones-by-segmented-worms-oligochaeta-enchytraeidae-mesenchytraeus
#19
Shirley A Lang, Naim Saglam, Joseph Kawash, Daniel H Shain
Segmented worms (Annelida) are among the most successful animal inhabitants of extreme environments worldwide. An unusual group of enchytraeid oligochaetes of genus Mesenchytraeus are abundant in the Pacific northwestern region of North America and occupy geographically proximal ecozones ranging from low elevation rainforests and waterways to high altitude glaciers. Along this altitudinal transect, Mesenchytraeus representatives from disparate habitat types were collected and subjected to deep mitochondrial and nuclear phylogenetic analyses...
October 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29020792/the-good-old-days-of-courtroom-questioning-changes-in-the-format-of-child-cross-examination-questions-over-60-years
#20
Rachel Zajac, Nina Westera, Andy Kaladelfos
Recent decades have seen an explosion of research into children's eyewitness capabilities and resulted in legal reform to render the adversarial trial process more child friendly. Many, however, have been left with the feeling that the most intimidating legal process for child complainants-cross-examination-has not changed meaningfully despite its potential to distort children's evidence. To test this possibility, we compared the cross-examination questioning of Australian child sexual abuse complainants in the 1950s to that used in contemporary cases...
January 1, 2017: Child Maltreatment
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