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https://www.readbyqxmd.com/read/28538868/comparative-analysis-of-death-by-suicide-in-brazil-and-in-the-united-states-descriptive-cross-sectional-time-series-study
#1
Alexander Abuabara, Allan Abuabara, Carin Albino Luçolli Tonchuk
CONTEXT AND OBJECTIVE: The World Health Organization recognizes suicide as a public health priority. Increased knowledge of suicide risk factors is needed in order to be able to adopt effective prevention strategies. The aim of this study was to analyze and compare the association between the Gini coefficient (which is used to measure inequality) and suicide death rates over a 14-year period (2000-2013) in Brazil and in the United States (US). The hypothesis put forward was that reduction of income inequality is accompanied by reduction of suicide rates...
March 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28538811/patient-survival-and-risk-of-death-after-prostate-cancer-treatment-in-the-brazilian-unified-health-system
#2
Sonia Faria Mendes Braga, Mirian Carvalho de Souza, Raphael Romie de Oliveira, Eli Iola Gurgel Andrade, Francisco de Assis Acurcio, Mariangela Leal Cherchiglia
OBJECTIVE: Analyze the probability of specific survival and factors associated with the risk of death of patients with prostate cancer who received outpatient cancer treatment in the Brazilian Unified Health System, Brazil. METHODS: Retrospective cohort study using the National Database of Oncology, developed through the deterministic-probabilistic pairing of health information systems: outpatient (SIA), hospital (SIH) and mortality (SIM). The probability of overall and specific survival was estimated by the time elapsed between the date of the first ambulatory treatment, from 2002 to 2003, until the patient's death or the end of the study...
May 15, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28538640/trends-in-the-epidemiology-of-major-burn-injury-among-hospitalized-patients-a-population-based-analysis
#3
Stephanie A Mason, Avery B Nathens, James Byrne, Alejandro Gonzalez, Rob Fowler, Paul Karanicolas, Rahim Moineddin, Marc G Jeschke
BACKGROUND: Burn-related mortality has decreased significantly over the past several decades. While often attributed in part to regionalization of burn care, this has not been evaluated at the population level. METHODS: We conducted a retrospective, population-based cohort study of all patients with > 20% total burned surface area (TBSA) burn injury in Ontario, Canada. Adult (>16y) patients injured between 2003-2013 were included. Deaths in the emergency department were excluded...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538637/factors-associated-with-intimate-partner-homicide-in-illinois-2005-2010-findings-from-the-illinois-violent-death-reporting-system
#4
Sana Yousuf, Suzanne McLone, Maryann Mason, Lisa Snow, Carol Gall, Karen Sheehan
BACKGROUND: Critical elements in intimate partner homicides (IPH) often go undocumented. Previous studies have highlighted precipitating causes, but few have examined the place of injury that led to the victim's death. We sought to describe IPH cases in Illinois, and in particular to examine factors surrounding the location of injury that led to the victim's death. METHODS: We analyzed data collected in the Illinois Violent Death Reporting System (IVDRS) to assess victim demographics, perpetrator characteristics, the victim/perpetrator relationship, and circumstances surrounding the location of injury that led to the victim's death...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538628/the-east-s-injury-control-and-violence-prevention-committee-s-annual-distracted-driving-outreach-event-evaluating-attitude-and-behavior-change-in-high-school-students
#5
Lisa Allee, Tracey Dechert, Sowmya R Rao, Marie Crandall, Ashley Christmas, Alexander Eastman, Thomas Duncan, Shannon Foster
BACKGROUND: The National Center for Statistics and Analysis report at least 8 deaths and 1,160 daily injuries due to distracted driving (DD) in the U.S. Drivers under age 20 are most likely to incur a distraction related fatal crash. We aimed to determine short and long term impact of a multi-modal educational program including student developed interventions, simulated driving experiences, and presentations by law enforcement and medical personnel. METHODS: A single day program aimed at teen DD prevention was conducted at a high school targeting students age 15 to 19 years old...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538414/clinical-predictors-for-the-manifestation-of-late-gadolinium-enhancement-after-acute-myocardial-infarction
#6
Nadine Abanador-Kamper, Lars Kamper, Marc Vorpahl, Hilmar Brinkmann, Vasiliki Karamani, Patrick Haage, Melchior Seyfarth
Despite prompt revascularization, some patients with acute myocardial infarction (AMI) develop myocardial scars, which can be visualized by late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMR). Our goal was to identify angiographic findings that were predictive for scar development in patients after reperfused AMI.We examined 136 patients after first ST-elevated myocardial infarction by CMR after a median of 4 days (range: 2-7). Patients with manifestation of LGE were matched to patients without LGE by means of age and gender...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538383/stratification-of-risk-groups-according-to-survival-after-recurrence-in-endometrial-cancer-patients
#7
Seung-Hyuk Shim, Dae-Yeon Kim, Hyun Jung Kim, Shin-Wha Lee, Jeong-Yeol Park, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
To identify prognostic factors for overall survival after recurrence (OSr) in endometrioid endometrial cancer (EC) patients and categorize patient subgroups that predict outcomes using these variables.Consecutive patients with recurrent endometrioid EC seen in our institution from 1989 to 2013 were retrospectively reviewed. Cox regression models were used to identify the clinicopathological factors associated with OSr. By summing scores proportionate to the hazard ratio (HR) for each significant variable, we stratified patients into 3 risk groups...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538377/time-distribution-of-injury-related-in-hospital-mortality-in-a-trauma-referral-center-in-south-of-iran-2010-2015
#8
Hamidreza Abbasi, Shahram Bolandparvaz, Mahnaz Yadollahi, Mehrdad Anvar, Zahra Farahgol
In Iran, there are no studies addressing trauma death timing and factors affecting time of death after injuries. This study aimed to examine time distribution of trauma deaths in an urban major trauma referral center with respect to victims' injury characteristics during 2010 to 2015.This was a cross-sectional study of adult trauma-related in-hospital deaths resulting from traffic-related accidents, falls, and violence-related injuries. Information on injury characteristics and time interval between admission and death was extracted from 3 hospital databases...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537691/the-influence-of-previous-robotic-experience-in-the-initial-learning-curve-of-laparoscopic-radical-prostatectomy
#9
José Anastácio Dias, Marcos F Dall'oglio, João Roberto Colombo, Rafael F Coelho, William Carlos Nahas
INTRODUCTION: This study analyzed the impact of the experience with Robotic-Assisted Laparoscopic Prostatectomy (RALP) on the initial experience with Laparoscopic Radical Prostatectomy (LRP) by examining perioperative results and early outcomes of 110 patients. LRPs were performed by two ro-botic fellowship trained surgeons with daily practice in RALP. PATIENTS AND METHODS: 110 LRP were performed to treat aleatory selected patients. The patients were divided into 4 groups for prospective analyses...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28535647/-effects-of-overexpression-of-mir-17-92-gene-cluster-on-the-biological-characteristics-of-prostate-cancer-cells-and-its-mechanism
#10
P Zhou, L Ma, J Zhou, J J Xu, F Liu, F Guo
Objective: To explore the effect and mechanism of over-expression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells. Methods: DU145 cells were transfected with miR-17-92 gene expression plasmid and clones with stable ectopic miR-17-92 overexpression were established. The cell viabilities of DU145-17-92 and DU145-control cells were monitored by xCELLigence system. Cell proliferation and apoptosis were analyzed by Ki-67 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28535630/-analysis-of-risk-factors-and-prognosis-for-bleeding-in-very-old-male-patients-with-stage-5-chronic-kidney-disease
#11
X Shen, Q G Ao, Q L Cheng, S Liu, J H Zhao, Q Ma, G Yang, Y Liu
Objective: To analyze the risk factors and prognosis of bleeding in very old male patients with stage 5 chronic kidney disease (CKD). Methods: The clinical data of 143 very old male patients with stage 5 CKD was retrospectively analyzed. According to the occurrence of bleeding, the patients were divided into two groups including the hemorrhage group and the non-hemorrhage group. The history of diseases, renal function, blood cell parameters and coagulation index were compared and analyzed between the two groups...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28535504/long-non-coding-rna-kcnq1ot1-promotes-cataractogenesis-via-mir-214-and-activation-of-the-caspase-1-pathway
#12
Xin Jin, Hao Jin, Yan Shi, Yiyuan Guo, Hong Zhang
BACKGROUND/AIMS: KCNQ1OT1 regulates the expression of tissue-specific imprinted genes within the Kcnq1 domain. Imprinted genes are positive regulators of apoptosis, one of the forms of cell death related to cataract formation, and thus may provide novel therapeutic targets for cataract treatment. Here, we studied the role of non-coding RNAs(ncRNA) in cataract formation. METHODS: Human lens epithelium cells (HLECs) were treated with H2O2, and the expression of KCNQ1OT1 and miR-214 was detected by qRT-PCR...
May 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28535456/effectiveness-of-treatment-for-opioid-use-disorder-a-national-five-year-prospective-observational-study-in-england
#13
Brian Eastwood, John Strang, John Marsden
BACKGROUND: This the first 5-year effectiveness study of publicly funded treatment for opioid use disorder (OUD) in England. METHODS: All adults initiating treatment in 2008/09 in all 149 local treatment systems reporting to the National Drug Treatment Monitoring System (n=54,347). Admission polydrug use sub-populations were identified by Latent Class Analysis. The treatment outcome measure was 'successful completion and no re-presentation within six months' (SCNR) analysed by multilevel, multivariable logistic regression and funnel plots to contrast outcome by treatment system...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28535359/association-between-nutrition-status-and-survival-in-elderly-patients-with-colorectal-cancer
#14
Katia Barao, Mariana Abe Vicente Cavagnari, Patricia Silva Fucuta, Nora Manoukian Forones
BACKGROUND: Aging patients with cancer have a higher risk of mortality and treatment-associated morbidity than younger patients. Nutrition status may play an important role in cancer mortality. We aimed to evaluate the survival time of elderly patients with colorectal cancer and its association with body mass index (BMI), the patient-generated subjective global assessment (PG-SGA), and phase angle (PA). MATERIALS AND METHODS: BMI, PG-SGA, and PA were determined for all patients (n = 250) at first assessment...
May 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28535307/intergenerational-impact-of-paternal-lifetime-exposures-to-both-folic-acid-deficiency-and-supplementation-on-reproductive-outcomes-and-imprinted-gene-methylation
#15
Lundi Ly, Donovan Chan, Mahmoud Aarabi, Mylène Landry, Nathalie A Behan, Amanda J MacFarlane, Jacquetta Trasler
STUDY QUESTION: Do paternal exposures to folic acid deficient (FD), and/or folic acid supplemented (FS) diets, throughout germ cell development adversely affect male germ cells and consequently offspring health outcomes? SUMMARY ANSWER: Male mice exposed over their lifetimes to both FD and FS diets showed decreased sperm counts and altered imprinted gene methylation with evidence of transmission of adverse effects to the offspring, including increased postnatal-preweaning mortality and variability in imprinted gene methylation...
May 23, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28535262/developmental-studies-of-maize-infesting-picture-winged-flies-diptera-ulidiidae
#16
Gaurav Goyal, Gregg S Nuessly, Dakshina R Seal, Gary J Steck, John L Capinera, Kenneth J Boote
Eleven species of picture-winged flies (Diptera: Ulidiidae) attack maize (Zea mays L.) in the Americas. Field and laboratory studies were used to determine developmental times on sweet corn ears for the three most common species attacking the crop in the United States, Chaetopsis massyla (Walker), Euxesta eluta Loew, and Euxesta stigmatias Loew. Egg plus larval stage developmental times were evaluated in early Spring and late Fall 2009, and late Spring 2010, by placing newly deposited eggs in protected ears in the field...
May 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28535171/cumulative-lactation-and-onset-of-hypertension-in-african-american-women
#17
Ellen M Chetwynd, Alison M Stuebe, Lynn Rosenberg, Melissa Troester, Diane Rowley, Julie R Palmer
Hypertension affects nearly one of three women and contributes to cardiovascular disease, the leading cause of death in the United States. Breastfeeding leads to metabolic changes that could reduce risks of hypertension. Hypertension disproportionately affects black women, but rates of breastfeeding lag behind the general population. In the Black Women's Health Study (N = 59,001), we conducted a nested case control analysis using unconditional logistic regression to estimate the association between breastfeeding and incident hypertension at ages 40-65 using data collected from 1995 to 2011...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535156/phase-ii-study-of-neoadjuvant-imatinib-in-large-gastrointestinal-stromal-tumours-of-the-stomach
#18
Yukinori Kurokawa, Han-Kwang Yang, Haruhiko Cho, Min-Hee Ryu, Toru Masuzawa, Sook Ryun Park, Sohei Matsumoto, Hyuk-Joon Lee, Hiroshi Honda, Oh Kyoung Kwon, Takashi Ishikawa, Kyung Hee Lee, Kazuhito Nabeshima, Seong-Ho Kong, Toshio Shimokawa, Jeong-Hwan Yook, Yuichiro Doki, Seock-Ah Im, Seiichi Hirota, Seokyung Hahn, Toshirou Nishida, Yoon-Koo Kang
BACKGROUND: Gastrointestinal stromal tumours (GISTs) with high-risk features have poor prognosis even if adjuvant treatment is given. Neoadjuvant imatinib may increase the cure rate by shrinking large GISTs and preserve organ function. METHODS: We conducted an Asian multinational phase II study for patients with gastric GISTs ≥10 cm. Patients received neoadjuvant imatinib (400 mg/day) for 6-9 months. The primary end point was R0 resection rate. RESULTS: A total of 56 patients were enroled in this study...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28535128/low-and-high-let-ionizing-radiation-induces-delayed-homologous-recombination-that-persists-for-two-weeks-before-resolving
#19
Christopher P Allen, Hirokazu Hirakawa, Nakako Izumi Nakajima, Sophia Moore, Jingyi Nie, Neelam Sharma, Mayumi Sugiura, Yuko Hoki, Ryoko Araki, Masumi Abe, Ryuichi Okayasu, Akira Fujimori, Jac A Nickoloff
Genome instability is a hallmark of cancer cells and dysregulation or defects in DNA repair pathways cause genome instability and are linked to inherited cancer predisposition syndromes. Ionizing radiation can cause immediate effects such as mutation or cell death, observed within hours or a few days after irradiation. Ionizing radiation also induces delayed effects many cell generations after irradiation. Delayed effects include hypermutation, hyper-homologous recombination, chromosome instability and reduced clonogenic survival (delayed death)...
May 23, 2017: Radiation Research
https://www.readbyqxmd.com/read/28535115/use-of-naloxone-nasal-spray-4%C3%A2-mg-in-the-community-setting-a-survey-of-use-by-community-organizations
#20
George K Avetian, Phillip Fiuty, Silvana Mazzella, Dave Koppa, Vivian Heye, Pratibha Hebbar
OBJECTIVE: Naloxone hydrochloride, an opioid antagonist, has been approved as a concentrated 4-mg dose intranasal formulation for the emergency treatment of known or suspected opioid overdose. This new formulation is easier to use and contains a higher dose of naloxone compared with earlier, unapproved kits. A survey of first responders and community-based organizations was conducted to understand initial real-world experiences with this new formulation for opioid overdose reversal. METHODS: In August 2016, 152 US organizations known to have received units of the approved 4-mg dose/unit naloxone nasal spray (NARCAN® Nasal Spray 4 mg [NNS]; Adapt Pharma, Inc...
May 23, 2017: Current Medical Research and Opinion
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