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https://www.readbyqxmd.com/read/29882060/exploring-the-ancestry-differentiation-and-inference-capacity-of-the-28-plex-aisnps
#1
Wei-Qi Hao, Jing Liu, Li Jiang, Jun-Ping Han, Ling Wang, Jiu-Ling Li, Quan Ma, Chao Liu, Hui-Jun Wang, Cai-Xia Li
Inferring an unknown DNA's ancestry using a set of ancestry-informative single nucleotide polymorphisms (SNPs) in forensic science is useful to provide investigative leads. This is especially true when there is no DNA database match or specified suspect. Thus, a set of SNPs with highly robust and balanced differential power is strongly demanded in forensic science. In addition, it is also necessary to build a genotyping database for estimating the ancestry of an individual or an unknown DNA. For the differentiation of Africans, Europeans, East Asians, Native Americans, and Oceanians, the Global Nano set that includes just 31 SNPs was developed by de la Puente et al...
June 7, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29731530/noble-metal-nanostructures-in-optical-biosensors-basics-and-their-introduction-to-anti-doping-detection
#2
Hedieh Malekzad, Parham Sahandi Zangabad, Hadi Mohammadi, Mohsen Sadroddini, Zahra Jafari, Niloofar Mahlooji, Somaye Abbaspour, Somaye Gholami, Mana Ghanbarpoor, Rahim Pashazadeh, Ali Beyzavi, Mahdi Karimi, Michael R Hamblin
Nanotechnology has illustrated significant potentials in biomolecular-sensing applications; particularly its introduction to anti-doping detection is of great importance. Illicit recreational drugs, substances that can be potentially abused, and drugs with dosage limitations according to the prohibited lists announced by the World Antidoping Agency (WADA) are becoming of increasing interest to forensic chemists. In this review, the theoretical principles of optical biosensors based on noble metal nanoparticles, and the transduction mechanism of commonly-applied plasmonic biosensors are covered...
March 2018: Trends in Analytical Chemistry: TRAC
https://www.readbyqxmd.com/read/29577705/-research-progress-of-vitreous-humor-detection-technique-on-estimation-of-postmortem-interval
#3
REVIEW
W C Duan, L M Lan, Y D Guo, L Zha, J Yan, Y J Ding, J F Cai
Estimation of postmortem interval (PMI) plays a crucial role in forensic study and identification work. Because of the unique anatomy location, vitreous humor is considered to be used for estima- ting PMI, which has aroused interest among scholars, and some researches have been carried out. The detection techniques of vitreous humor are constantly developed and improved which have been gradually applied in forensic science, meanwhile, the study of PMI estimation using vitreous humor is updated rapidly. This paper reviews various techniques and instruments applied to vitreous humor detection, such as ion selective electrode, capillary ion analysis, spectroscopy, chromatography, nano-sensing technology, automatic biochemical analyser, flow cytometer, etc...
February 2018: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29164281/monitoring-of-post-mortem-changes-of-saliva-n-glycosylation-by-nano-lc-ms
#4
Bum Jin Kim, Chanyoung Han, Hantae Moon, Joseph Kwon, Ik-Soon Jang, Si-Keun Lim, Ki-Won Park, Jong-Soon Choi, Hyun Joo An
The estimation of post-mortem interval (PMI) is a crucial part for investigations of crime and untimely deaths in forensic science. However, standard methods of PMI estimation are easily confounded by extenuating circumstances and/or environmental factors. Therefore, a panel of PMI markers obtained from a more acceptable and accurate method is necessary to definitely determine time of death. Saliva, one of the vital fluids encountered at crime scenes, contains various glycoproteins that are highly affected by biochemical environment...
January 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29151005/synthesis-of-a-novel-polymeric-magnetic-solid-phase-extraction-adsorbent-for-selective-extraction-of-amphetamine-from-urine-samples-coupled-with-high-performance-liquid-chromatography
#5
Arezou Taghvimi, Marjan Ghorbani, Hamed Hamishehkar
A novel pH-responsive block copolymer (Poly ethylene glycol-b-poly (N,N-dimethylaminoethylmethacrylate-co-maleic acid) was designed for the decoration and stabilization of magnetic nanoparticles (MNPs) as an efficient magnetic nano adsorbent for extraction of amphetamine (AM) from biological urine samples to be determined by high performance liquid chromatography-ultra violet detector (HPLC-UV). Full characterization of the synthesized polymeric magnetic nanoparticles (PMNPs) were followed by various techniques like Fourier transform infrared (FT-IR) spectroscopy, powder x-ray diffraction (XRD), scanning electron microscopy (SEM), and vibrating sample magnetometer (VSM)...
November 18, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28866222/detection-of-alprazolam-with-a-lab-on-paper-economical-device-integrated-with-urchin-like-ag-pd-shell-nano-hybrids
#6
Jagriti Narang, Nitesh Malhotra, Chaitali Singhal, Ashish Mathur, Anoop Krishna Pn, C S Pundir
We present results of the studies relating to fabrication of a microfluidic biosensor chip based on urchin like Ag@ Pd shell nano-hybrids that is capable of sensing alprazolam through electrochemical detection. Using this chip we demonstrate, with high reliability and in a time efficient manner, the detection of alprazolam present in buffer solutions at clinically relevant concentrations. Methylene blue (MB) was also doped as redox transition substance for sensing alprazolam. Nano-hybrids modified EμPAD showed wide linear range 1-300ng/ml and low detection limit of 0...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28214756/multifarious-applications-of-atomic-force-microscopy-in-forensic-science-investigations
#7
REVIEW
Gaurav Pandey, Maithri Tharmavaram, Deepak Rawtani, Sumit Kumar, Y Agrawal
Forensic science is a wide field comprising of several subspecialties and uses methods derived from natural sciences for finding criminals and other evidence valid in a legal court. A relatively new area; Nano-forensics brings a new era of investigation in forensic science in which instantaneous results can be produced that determine various agents such as explosive gasses, biological agents and residues in different crime scenes and terrorist activity investigations. This can be achieved by applying Nanotechnology and its associated characterization techniques in forensic sciences...
April 2017: Forensic Science International
https://www.readbyqxmd.com/read/28033585/carbon-coated-magnetic-nanoparticles-as-a-novel-magnetic-solid-phase-extraction-adsorbent-for-simultaneous-extraction-of-methamphetamine-and-ephedrine-from-urine-samples
#8
Arezou Taghvimi, Hamed Hamishehkar
This paper develops a highly selective, specific and efficient method for simultaneous determination of ephedrine and methamphetamine by a new carbon coated magnetic nanoparticles (C/MNPs) as a magnetic solid phase extraction (MSPE) adsorbent in biological urine medium. The characterization of synthesized magnetic nano adsorbent was completely carried out by various characterization techniques like Fourier transform infrared (FT-IR) spectroscopy, powder x-ray diffraction (XRD), scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM)...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27766177/direct-analysis-of-pharmaceutical-drugs-using-nano-desi-ms
#9
Carlos Cardoso-Palacios, Ingela Lanekoff
Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27760392/nanoscale-analysis-of-degradation-processes-of-cellulose-fibers
#10
Lorenzo Teodonio, Mauro Missori, Dominika Pawcenis, Joanna Łojewska, Francesco Valle
Mapping the morphological and nano-mechanical properties of cellulose fibers within paper sheets or textile products at the nano-scale level by using atomic force microscopy is a challenging task due to the huge surface level variation of these materials. However this task is fundamental for applications in forensic or cultural heritage sciences and for the industrial characterization of materials. In order to correlate between nano-mechanical properties and local nanometer scale morphology of different layers of cellulose fibers, a new strategy to prepare samples of isolated cellulose fibers was designed...
December 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/26881328/the-global-aims-nano-set-a-31-plex-snapshot-assay-of-ancestry-informative-snps
#11
M de la Puente, C Santos, M Fondevila, L Manzo, Á Carracedo, M V Lareu, C Phillips
A 31-plex SNaPshot assay, named 'Global AIMs Nano', has been developed by reassembling the most differentiated markers of the EUROFORGEN Global AIM-SNP set. The SNPs include three tri-allelic loci and were selected with the goal of maintaining a balanced differentiation of: Africans, Europeans, East Asians, Oceanians and Native Americans. The Global AIMs Nano SNP set provides higher divergence between each of the five continental population groups than previous small-scale AIM sets developed for forensic ancestry analysis with SNaPshot...
May 2016: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/26874052/use-of-atomic-force-microscopy-in-the-forensic-application-of-chronological-order-of-toners-and-stamping-inks-in-questioned-documents
#12
Tae-Yi Kang, Joong Lee, Byung-Wook Park
This paper describes the application of the atomic force microscopy (AFM) as a nano-indentation method and introduces a new method of identifying the chronological order of the application of the toner and stamping ink on the surface of documents by removing either of them. Various toners were used as samples for the AFM nano-indentation method. The chronological order of the application of the toner and stamping ink with either the toner placed over the stamping ink or the stamping ink placed over the toner, could be identified, regardless of the kinds of toners made by various companies...
April 2016: Forensic Science International
https://www.readbyqxmd.com/read/26844917/massively-parallel-sequencing-of-the-entire-control-region-and-targeted-coding-region-snps-of-degraded-mtdna-using-a-simplified-library-preparation-method
#13
Eun Young Lee, Hwan Young Lee, Se Yoon Oh, Sang-Eun Jung, In Seok Yang, Yang-Han Lee, Woo Ick Yang, Kyoung-Jin Shin
The application of next-generation sequencing (NGS) to forensic genetics is being explored by an increasing number of laboratories because of the potential of high-throughput sequencing for recovering genetic information from multiple markers and multiple individuals in a single run. A cumbersome and technically challenging library construction process is required for NGS. In this study, we propose a simplified library preparation method for mitochondrial DNA (mtDNA) analysis that involves two rounds of PCR amplification...
May 2016: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/26515005/metabolism-of-human-insulin-after-subcutaneous-administration-a-possible-means-to-uncover-insulin-misuse
#14
Andreas Thomas, Paul Brinkkötter, Wilhelm Schänzer, Mario Thevis
The misuse of insulin for performance enhancement in sport or as toxic agent has frequently been reported in the past. In contrast to synthetic insulin analogues, the administration of recombinant human insulin is hardly recognized by mass spectrometry. The present study was designed to uncover the misuse of recombinant human insulin for doping control purposes as well as for forensic applications. It is hypothesized that an altered metabolite profile of circulating insulin prevails after subcutaneous administration due to exposure of insulin to epidermal proteases...
October 15, 2015: Analytica Chimica Acta
https://www.readbyqxmd.com/read/26345678/flexible-ag-c60-nano-biosensors-based-on-surface-plasmon-coupled-emission-for-clinical-and-forensic-applications
#15
Pradyumna Mulpur, Sairam Yadavilli, Praharsha Mulpur, Neeharika Kondiparthi, Bishwambhar Sengupta, Apparao M Rao, Ramakrishna Podila, Venkataramaniah Kamisetti
The relatively low sensitivity of fluorescence detection schemes, which are mainly limited by the isotropic nature of fluorophore emission, can be overcome by utilizing surface plasmon coupled emission (SPCE). In this study, we demonstrate directional emission from fluorophores on flexible Ag-C60 SPCE sensor platforms for point-of-care sensing, in healthcare and forensic sensing scenarios, with at least 10 times higher sensitivity than traditional fluorescence sensing schemes. Adopting the highly sensitive Ag-C60 SPCE platform based on glass and novel low-cost flexible substrates, we report the unambiguous detection of acid-fast Mycobacterium tuberculosis (Mtb) bacteria at densities as low as 20 Mtb mm(-2); from non-acid-fast bacteria (e...
October 14, 2015: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/26318597/silane-modified-magnetic-nanoparticles-as-a-novel-adsorbent-for-determination-of-morphine-at-trace-levels-in-human-hair-samples-by-high-performance-liquid-chromatography-with-diode-array-detection
#16
Ali Boojaria, Mahboubeh Masrournia, Hamideh Ghorbani, Abdolhossein Ebrahimitalab, Mina Miandarhoie
In this paper we report a novel, sensitive, and rapid method of magnetic solid phase extraction based on surface modified magnetic nanoparticles as a novel nano sorbent for HPLC determination of morphine with diode array detection in human hair samples. Factors affecting the extraction efficiency of the proposed method, including the sample pH, quantity of magnetic nanoparticles, sample volume, desorption solvent type and its volume, and extraction time were investigated and optimized. Under the optimized experimental conditions, a good linearity was observed in the range of 1-800 µgL(-1) for the morphine, with a correlation coefficient (R (2)) of 0...
December 2015: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/25460874/nano-iniferter-based-imprinted-sensor-for-ultra-trace-level-detection-of-prostate-specific-antigen-in-both-men-and-women
#17
Santanu Patra, Ekta Roy, Rashmi Madhuri, Prashant K Sharma
In this work, a sensitive and selective electrochemical sensor for detection of prostate specific antigen (PSA) was developed using surface imprinting and nanotechnology. The multiwalled carbon nanotubes (MWCNTs) decorated with manganese nanoparticles was functionalized with thio-group to make a nano-iniferter. This nano-iniferter was used as a platform to synthesize a three-dimensional molecularly imprinted polymer matrix for PSA by controlled radical polymerization technique. The PSA-sensor displayed good analytical performance for the detection of PSA by square wave and differential pulse stripping voltammetric techniques...
April 15, 2015: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/24916100/surface-assisted-laser-desorption-ionization-mass-spectrometry-techniques-for-application-in-forensics
#18
REVIEW
Taryn Guinan, Paul Kirkbride, Paul E Pigou, Maurizio Ronci, Hilton Kobus, Nicolas H Voelcker
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is an excellent analytical technique for the rapid and sensitive analysis of macromolecules (>700 Da), such as peptides, proteins, nucleic acids, and synthetic polymers. However, the detection of smaller organic molecules with masses below 700 Da using MALDI-MS is challenging due to the appearance of matrix adducts and matrix fragment peaks in the same spectral range. Recently, nanostructured substrates have been developed that facilitate matrix-free laser desorption ionization (LDI), contributing to an emerging analytical paradigm referred to as surface-assisted laser desorption ionization (SALDI) MS...
November 2015: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/24445004/structure-mechanical-function-relations-at-nano-scale-in-heat-affected-human-dental-tissue
#19
Tan Sui, Michael A Sandholzer, Eric Le Bourhis, Nikolaos Baimpas, Gabriel Landini, Alexander M Korsunsky
The knowledge of the mechanical properties of dental materials related to their hierarchical structure is essential for understanding and predicting the effect of microstructural alterations on the performance of dental tissues in the context of forensic and archaeological investigation as well as laser irradiation treatment of caries. So far, few studies have focused on the nano-scale structure-mechanical function relations of human teeth altered by chemical or thermal treatment. The response of dental tissues to thermal treatment is thought to be strongly affected by the mineral crystallite size, their spatial arrangement and preferred orientation...
April 2014: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/24311968/development-of-rapid-methodologies-for-the-isolation-and-quantitation-of-drug-metabolites-by-differential-mobility-spectrometry-mass-spectrometry
#20
Adam B Hall, Stephen L Coy, Erkinjon Nazarov, Paul Vouros
Clinical and forensic toxicology laboratories are inundated with thousands of samples requiring lengthy chromatographic separations prior to mass spectrometry. Here, we employ differential mobility spectrometry (DMS) interfaced to nano-electrospray ionization-mass spectrometry to provide a rapid ion filtration technique for the separation of ions in gas phase media prior to mass spectral analysis on a DMS-integrated AB SCIEX API 3000 triple-quadrupole mass spectrometer. DMS is efficient at the rapid separation of ions under ambient conditions and provides many advantages when used as an ion filtration technique in tandem with mass spectrometry (MS) and MS/MS...
September 1, 2012: International Journal for Ion Mobility Spectrometry
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