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Roger McIntyre

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https://www.readbyqxmd.com/read/28915125/air-pollution-aeroallergens-and-suicidality-a-review-of-the-effects-of-air-pollution-and-aeroallergens-on-suicidal-behavior-and-an-exploration-of-possible-mechanisms
#1
Renee-Marie Ragguett, Danielle S Cha, Mehala Subramaniapillai, Nicole E Carmona, Yena Lee, Duanduan Yuan, Carola Rong, Roger S McIntyre
OBJECTIVE: Risk factors for suicide can be broadly categorized as sociodemographic, clinical and treatment. There is interest in environmental risk and protection factors for suicide. Emerging evidence suggests a link between environmental factors in the form of air pollution and aeroallergens in relation to suicidality. METHODS: Herein, we conducted a systematic review of 15 articles which have met inclusion criteria on the aforementioned effects. RESULTS: The majority of the reviewed articles reported an increased suicide risk alongside increased air pollutants or aeroallergens (i...
September 15, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28914725/sleep-duration-and-quality-as-related-to-left-ventricular-structure-and-function
#2
Jae-Hon Lee, Sung Keun Park, Jae-Hong Ryoo, Chang-Mo Oh, Jeong Gyu Kang, Rodrigo B Mansur, Jeffrey E Alfonsi, Yena Lee, Sun-Han Shin, Roger S McIntyre, Ju Young Jung
OBJECTIVE: Inadequate sleep is associated with increased risk of cardiovascular events; however, the associations between sleep duration or quality and cardiac function or structure are not well understood. This cross-sectional study was conducted to investigate to what extent sleep duration and quality are associated with left ventricular (LV) diastolic dysfunction or structural deterioration. METHODS: A total of 31,598 healthy Korean adults who received echocardiography and completed the Pittsburg Sleep Quality Index were enrolled in this study...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28899821/correlation-between-brain-circuit-segregation-and-obesity
#3
Hse-Huang Chao, Yin-To Liao, Vincent Chin-Hung Chen, Cheng-Jui Li, Roger S McIntyre, Yena Lee, Jun-Cheng Weng
Obesity is a major public health problem. Herein, we aim to identify the correlation between brain circuit segregation and obesity using multimodal functional magnetic resonance imaging (fMRI) techniques and analysis. Twenty obese patients (BMI=37.66±5.07) and 30 healthy controls (BMI=22.64±3.45) were compared using neuroimaging and assessed for symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). All participants underwent resting-state fMRI (rs-fMRI) and T1-weighted imaging using a 1...
September 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28867303/treatment-with-a-glp-1r-agonist-over-four-weeks-promotes-weight-loss-moderated-changes-in-frontal-striatal-brain-structures-in-individuals-with-mood-disorders
#4
Rodrigo B Mansur, Andre Zugman, Juhie Ahmed, Danielle S Cha, Mehala Subramaniapillai, Yena Lee, Julie Lovshin, Jung G Lee, Jae-Hon Lee, Vladislav Drobinin, Jason Newport, Elisa Brietzke, Eva Z Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas Hajek, Roger S McIntyre
Cognitive deficits are a core feature across psychiatric disorders. Emerging evidence indicates that metabolic pathways are highly relevant for the substrates and phenomenology of the cognitive domain. Herein, we aimed to determine the effects of liraglutide, a GLP-1R agonist, on brain structural/volumetric parameters in adults with a mood disorder. This is the secondary analysis of a 4-week, pilot, proof-of-concept, open-label study. Participants (N=19) exhibiting impairments in executive function with either major depressive disorder (MDD) or bipolar disorder (BD) were recruited...
August 31, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28858441/the-thinc-integrated-tool-thinc-it-screening-assessment-for-cognitive-dysfunction-validation-in-patients-with-major-depressive-disorder
#5
Roger S McIntyre, Michael W Best, Christopher R Bowie, Nicole E Carmona, Danielle S Cha, Yena Lee, Mehala Subramaniapillai, Rodrigo B Mansur, Harry Barry, Bernhard T Baune, Larry Culpepper, Philippe Fossati, Tracy L Greer, Catherine Harmer, Esther Klag, Raymond W Lam, Hans-Ulrich Wittchen, John Harrison
OBJECTIVE: To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). METHODS: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100)...
July 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28856464/dosage-of-methylphenidate-and-traumatic-brain-injury-in-adhd-a-population-based-study-in-taiwan
#6
Yin-To Liao, Yao-Hsu Yang, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Tsu-Nai Wang, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
Preventive effect of stimulants on the risk of brain injuries had been reported. The aim of this study is to determine the extent to which methylphenidate (MPH) prescription moderates the risk of traumatic brain injuries (TBI) in individuals with attention-deficit/hyperactivity disorder (ADHD). Individuals with a recent diagnosis of ADHD between January 1997 and December 2013 (n = 163,618) were identified from Taiwan's National Health Insurance Research Database. A total of 124,438 adolescents and children with ADHD and without prior TBI diagnoses were included and evaluated for subsequent TBI...
August 30, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28837274/association-between-bone-mineral-density-and-depressive-symptoms-in-a-population-based-sample
#7
Rocco D Hlis, Roger S McIntyre, Naim M Maalouf, Erin Van Enkevort, E Sherwood Brown
OBJECTIVE: This analysis was conducted to determine the relationship between bone mineral density (BMD) and depressive symptoms in a population-based cohort. METHODS: Data were extracted from the second phase of the Dallas Heart Study (DHS-2), a large, multiethnic population sample in Dallas County, Texas, from September 1, 2007, to December 31, 2009. Depressive symptom severity was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR₁₆), which is derived from DSM-IV major depressive disorder criteria...
August 22, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28830676/gluten-related-illness-and-severe-mental-disorders-a-comprehensive-review
#8
REVIEW
Elisa Brietzke, Raphael O Cerqueira, Rodrigo B Mansur, Roger S McIntyre
The putative role of gluten in the pathophysiology of severe mental illnesses remains uncertain and there is doubt about the possible benefit of gluten-free diets for individuals affected by psychosis and mood disorders. The objective of this review was to summarize the findings linking gluten related conditions to pathophysiological substrates implicated in schizophrenia and mood disorders and review the evidences of potential benefits of glute-free diets in these populations. A literature search was conducted within PubMed and Scielo databases including references from inception until March 1st 2017...
August 19, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28813113/impact-of-inequalities-in-health-care-on-the-mortality-risk-of-individuals-with-severe-mental-illnesses
#9
EDITORIAL
Elisa Brietzke, Rodrigo B Mansur, Roger S McIntyre
No abstract text is available yet for this article.
July 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28804178/online-distribution-channel-increases-article-usage-on-mendeley-a-randomized-controlled-trial
#10
Paul Kudlow, Matthew Cockerill, Danielle Toccalino, Devin Bissky Dziadyk, Alan Rutledge, Aviv Shachak, Roger S McIntyre, Arun Ravindran, Gunther Eysenbach
Prior research shows that article reader counts (i.e. saves) on the online reference manager, Mendeley, correlate to future citations. There are currently no evidenced-based distribution strategies that have been shown to increase article saves on Mendeley. We conducted a 4-week randomized controlled trial to examine how promotion of article links in a novel online cross-publisher distribution channel (TrendMD) affect article saves on Mendeley. Four hundred articles published in the Journal of Medical Internet Research were randomized to either the TrendMD arm (n = 200) or the control arm (n = 200) of the study...
2017: Scientometrics
https://www.readbyqxmd.com/read/28689181/subthreshold-hypomania-affects-half-of-patients-with-bipolar-disorder-presenting-with-depressive-symptoms
#11
EDITORIAL
Roger S McIntyre
No abstract text is available yet for this article.
July 8, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28688267/factors-affecting-lumbar-surgery-outcome-a-nation-wide-population-based-retrospective-study
#12
Vincent Chin-Hung Chen, Yao-Hsu Yang, Pin-Yuan Chen, Jen-Tsung Yang, Carl P C Chen, Chi-Jen Chen, Mong Liang Lu, Yena Lee, Roger S McIntyre, Yin-Cheng Huang
BACKGROUND: Lower back pain is a very common symptom and treatment strategies vary according the severity and duration of illness. Surgical approaches are becoming increasingly popular with the advent of new and less invasive technologies; however, treatment outcomes are not yet well established on a population-based level. Taiwan's National Health Insurance Research Database (NHIRD) is longitudinal and includes 98% of the population since its inception in 1995. The database includes the ICD 9...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28682531/florida-best-practice-psychotherapeutic-medication-guidelines-for-adults-with-major-depressive-disorder
#13
REVIEW
Roger S McIntyre, Trisha Suppes, Rajiv Tandon, Michael Ostacher
OBJECTIVE: Herein we provide the 2015 update for the Florida Best Practice Psychotherapeutic Medication Guidelines (FPG) for major depressive disorder (MDD). The FPG represent evidence-based decision support for practitioners providing care to adults with MDD. PARTICIPANTS: The consensus meeting included representatives from the Florida Agency for Health Care Administration (FAHCA), advocacy members, academic experts in MDD, and multidisciplinary mental health clinicians, as well as health policy experts...
June 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28667888/cognitive-impairment-as-measured-by-the-thinc-integrated-tool-thinc-it-association-with-psychosocial-function-in-major-depressive-disorder
#14
Danielle S Cha, Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Yena Lee, Jae Hon Lee, JungGoo Lee, Joshua D Rosenblat, Margarita Shekotikhina, Caroline Park, Carola Rong, Tracy L Greer, Raymond Lam, Bernhard T Baune, John Harrison, Roger S McIntyre
BACKGROUND: Psychosocial impairment represents an important treatment target in major depressive disorder (MDD). The majority of patients with MDD do not regain premorbid levels of psychosocial functioning despite the resolution of core depressive symptoms. This study aimed to investigate the respective effects of cognitive function and depression severity on impaired psychosocial function in MDD. METHODS: Adults aged 18-65 with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls participated in a cross-sectional study validating the THINC-integrated tool (THINC-it), a cognitive screening tool comprised of objective and subjective measures of cognitive function...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28666060/ssris-associated-with-decreased-risk-of-hepatocellular-carcinoma-a-population-based-case-control-study
#15
Hsiang-Lin Chan, Wei-Che Chiu, Vincent Chin-Hung Chen, Kuo-You Huang, Tsu-Nai Wang, Yena Lee, Roger S McIntyre, Tsai-Ching Hsu, Charles Tzu-Chi Lee, Bor-Show Tzang
BACKGROUND: Hepatocellular carcinoma (HCC) is the second leading cancer-related cause of mortality worldwide. Antidepressants, especially selective serotonin re-uptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited. OBJECTIVE: he present study aimed to investigate if the effect of all kinds of SSRIs on HCC was the same or not using population-based study. METHODS: The nationwide population-based study herein using Taiwan's National Health Insurance Research Database included a total of 59,859 cases with HCC and 285,124 matched controls...
June 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28645967/the-bipolar-illness-onset-study-research-protocol-for-the-bio-cohort-study
#16
Lars Vedel Kessing, Klaus Munkholm, Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Lars Bo Nielsen, Ruth Frikke-Schmidt, Claus Ekstrøm, Ole Winther, Bente Klarlund Pedersen, Henrik Enghusen Poulsen, Roger S McIntyre, Flavio Kapczinski, Wagner F Gattaz, Jakob Bardram, Mads Frost, Oscar Mayora, Gitte Moos Knudsen, Mary Phillips, Maj Vinberg
INTRODUCTION: Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%-2%, a high risk of recurrence of manic and depressive episodes, a lifelong elevated risk of suicide and a substantial heritability. The course of illness is frequently characterised by progressive shortening of interepisode intervals with each recurrence and increasing cognitive dysfunction in a subset of individuals with this condition. Clinically, diagnostic boundaries between bipolar disorder and other psychiatric disorders such as unipolar depression are unclear although pharmacological and psychological treatment strategies differ substantially...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28599348/a-pilot-open-label-8-week-study-evaluating-the-efficacy-safety-and-tolerability-of-adjunctive-minocycline-for-the-treatment-of-bipolar-i-ii-depression
#17
Joanna K Soczynska, Sidney H Kennedy, Mohammad Alsuwaidan, Rodrigo B Mansur, Madeline Li, Mary Pat McAndrews, Elisa Brietzke, Hanna O Woldeyohannes, Valerie H Taylor, Roger S McIntyre
OBJECTIVES: The objectives of the study were to determine if adjunctive minocycline mitigates depressive symptom severity and improves cognitive function in individuals with bipolar I/II disorder (BD). The study also aimed to determine if changes in depressive and/or cognitive symptoms over the course of treatment were associated with changes in circulating inflammatory cytokine levels. METHODS: A total of 29 (intention-to-treat: n=27) adults meeting DSM-IV-TR criteria for a major depressive episode as part of bipolar I or II disorder (i...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28593878/microbiota-abnormalities-and-the-therapeutic-potential-of-probiotics-in-the-treatment-of-mood-disorders
#18
Adiel C Rios, Pawan Kumar Maurya, Mariana Pedrini, Maiara Zeni-Graiff, Elson Asevedo, Rodrigo B Mansur, Andrea Wieck, Rodrigo Grassi-Oliveira, Roger S McIntyre, Mirian A F Hayashi, Elisa Brietzke
Major depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut microbiota in processes relevant to etiopathology of central nervous system-based disorders. The objective of this article was to critically evaluate the evidence supporting the link between gastrointestinal microbiota and mood disorders and to discuss the potential benefits of using probiotics in the treatment of MDD and BD...
May 8, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28590365/the-efficacy-of-psychostimulants-in-major-depressive-episodes-a-systematic-review-and-meta-analysis
#19
Roger S McIntyre, Yena Lee, Aileen J Zhou, Joshua D Rosenblat, Evyn M Peters, Raymond W Lam, Sidney H Kennedy, Carola Rong, Jeanette M Jerrell
BACKGROUND: Psychostimulants are frequently prescribed off-label for adults with major depressive disorder or bipolar disorder. The frequent and increasing usage of stimulants in mood disorders warrants a careful appraisal of the efficacy of this class of agents. Herein, we aim to estimate the efficacy of psychostimulants in adults with unipolar or bipolar depression. METHODS: The PubMed/Medline database was searched from inception to January 16, 2016 for randomized, placebo-controlled clinical trials investigating the antidepressant efficacy of psychostimulants in the treatment of adults with unipolar or bipolar depression...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28566945/inflammation-opportunities-for-treatment-stratification-among-individuals-diagnosed-with-mood-disorders
#20
Mehala Subramaniapillai, Nicole E Carmona, Carola Rong, Roger S McIntyre
Mood disorders continue to be a significant burden to those affected, resulting in significant illness-associated disability and premature mortality. In addition to mood disturbance, individuals also suffer from other transdiagnostic impairments (eg, anhedonia and cognitive impairment). Although there have been significant advancements in psychiatric treatment over the last few decades, treatment efficacy (eg, symptom remission, lack of functional recovery, and disease modification) continues to be an important limitation...
March 2017: Dialogues in Clinical Neuroscience
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