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Roger McIntyre

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https://www.readbyqxmd.com/read/29154157/efficacy-of-antidepressants-on-measures-of-workplace-functioning-in-major-depressive-disorder-a-systematic-review
#1
REVIEW
Yena Lee, Joshua D Rosenblat, JungGoo Lee, Nicole E Carmona, Mehala Subramaniapillai, Margarita Shekotikhina, Rodrigo B Mansur, Elisa Brietzke, Jae-Hon Lee, Roger C Ho, Samantha J Yim, Roger S McIntyre
INTRODUCTION: Work-related disability and productivity loss in Major Depressive Disorder (MDD) are critical determinants of patient quality of life and contribute significantly to the human and economic costs of MDD. Notwithstanding the return to work and pre-morbid levels of functioning as a critical therapeutic objective among individuals with MDD, it is unclear whether antidepressant treatment significantly and reliably improves measures of workplace functioning. Herein, we investigate to what extent antidepressant treatment improves workplace functioning among adults with MDD...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29121517/suicide-risk-reduction-in-youths-with-attention-deficit-hyperactivity-disorder-prescribed-methylphenidate-a-taiwan-nationwide-population-based-cohort-study
#2
Sophie Hsin-Yi Liang, Yao-Hsu Yang, Ting-Yu Kuo, Yin-To Liao, Tzu-Chin Lin, Yena Lee, Roger S McIntyre, Brent A Kelsen, Tsu-Nai Wang, Vincent Chin-Hung Chen
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) youths have increased suicide risk. Nevertheless, the beneficial effects of methylphenidate (MPH) on suicide attempt have received relatively little attention. AIMS: To investigate the MPH usage and the risk of suicide attempt among ADHD youths. METHODS: We identified 84,898 youths less than 18 years old with ADHD diagnosis between 1997 and 2013 from National Health Insurance, and examined whether MPH use affected suicide attempt risk using Cox proportional-hazards models...
November 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29105003/anxiety-irritability-and-agitation-as-indicators-of-bipolar-mania-with-depressive-symptoms-a-post-hoc-analysis-of-two-clinical-trials
#3
Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H Young, Roger S McIntyre
BACKGROUND: Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identification of this more severe form of BD-I. Using data from two clinical trials, the aims of this post hoc analysis were to describe the phenomenology of bipolar mania in terms of AIA and depressive symptoms, and to evaluate the influence of these symptoms on the likelihood of remission during treatment...
November 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29102836/efficacy-and-tolerability-of-minocycline-for-depression-a-systematic-review-and-meta-analysis-of-clinical-trials
#4
REVIEW
Joshua D Rosenblat, Roger S McIntyre
BACKGROUND: Minocycline has been identified as a potential novel treatment for depression. The objective of the current review is to determine the overall antidepressant efficacy and tolerability of minocycline. METHODS: Completed and ongoing clinical trials of minocycline for depression (both bipolar and unipolar) published prior to September 12, 2017 were identified through searching relevant databases. Using a random-effects model, data from randomized controlled trials (RCTs) were pooled to determine the antidepressant effect size of minocycline compared to placebo...
October 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29102835/the-differential-association-between-history-of-childhood-sexual-abuse-and-body-mass-index-in-early-and-late-stages-of-bipolar-disorder
#5
Emilie Leclerc, Rodrigo B Mansur, Rodrigo Grassi-Oliveira, Quirino Cordeiro, Flavio Kapczinski, Roger S McIntyre, Elisa Brietzke
BACKGROUND: History of distal stressors such as childhood trauma is a well-established, non-specific vulnerability factor for multiple mental illnesses. The objective of this study was to investigate the possible association between history of childhood trauma and body mass index (BMI) in individuals in early and late stages of bipolar disorder (BD) and to verify is there was any difference in the association of sexual abuse history and obesity in early versus late stages of BD. METHODS: Seventy-one euthymic BD-type I patients and eighty-one healthy controls were evaluated using the Childhood Trauma Questionnaire (CTQ) and body mass index (BMI)...
October 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29084144/bipolar-disorder-and-immune-dysfunction-epidemiological-findings-proposed-pathophysiology-and-clinical-implications
#6
REVIEW
Joshua D Rosenblat, Roger S McIntyre
Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated epidemiological studies have demonstrated that BD has high rates of inflammatory medical comorbidities, including autoimmune disorders, chronic infections, cardiovascular disease and metabolic disorders. Cytokine studies have demonstrated that BD is associated with chronic low-grade inflammation with further increases in pro-inflammatory cytokine levels during mood episodes. Several mechanisms have been identified to explain the bidirectional relationship between BD and immune dysfunction...
October 30, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29082802/drug-drug-interactions-as-a-result-of-co-administering-%C3%AE-9-thc-and-cbd-with-other-psychotropic-agents
#7
Carola Rong, Nicole E Carmona, Yena L Lee, Renee-Marie Ragguett, Zihang Pan, Joshua D Rosenblat, Mehala Subramaniapillai, Margarita Shekotikhina, Fahad Almatham, Asem Alageel, Rodrigo Mansur, Roger C Ho, Roger S McIntyre
To determine, via narrative, non-systematic review of pre-clinical and clinical studies, whether the effect of cannabis on hepatic biotransformation pathways would be predicted to result in clinically significant drug-drug interactions (DDIs) with commonly prescribed psychotropic agents. Areas covered: A non-systematic literature search was conducted using the following databases: PubMed, PsycInfo, and Scopus from inception to January 2017. The search term cannabis was cross-referenced with the terms drug interactions, cytochrome, cannabinoids, cannabidiol, and medical marijuana...
October 31, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29081307/efficacy-of-vortioxetine-in-working-patients-with-generalized-anxiety-disorder
#8
Michael Cronquist Christensen, Henrik Loft, Ioana Florea, Roger S McIntyre
BACKGROUND: Vortioxetine is an approved antidepressant that has also demonstrated positive effects on anxiety symptoms in subjects with generalized anxiety disorder (GAD). This post-hoc analysis evaluates the efficacy of vortioxetine in GAD subjects who are working and/or pursuing an education. METHODS: In study NCT00744627, 301 GAD subjects were randomized to vortioxetine 5 mg or placebo for 8 weeks. Efficacy measures included the Hamilton Anxiety Rating Scale (HAM-A) total score, response/remission, global functioning (Sheehan Disability Scale [SDS]), and quality of life (Short Form-36 Health Survey)...
October 30, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29073751/paroxetine-versus-venlafaxine-and-escitalopram-in-korean-patients-with-major-depressive-disorder-a-randomized-rater-blinded-six-week-study
#9
Young Sup Woo, Roger S McIntyre, Jung-Bum Kim, Min-Soo Lee, Jae-Min Kim, Hyeon Woo Yim, Tae-Youn Jun
Objective: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). Methods: A total of 449 Korean MDD patients were recruited in a six-week, randomized, rater-blinded, active-controlled trial and were evenly randomized to paroxetine, venlafaxine, or escitalopram treatment. Results: When comparing the mean difference for the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating Scale (HDRS) total scores during six weeks, paroxetine (-6...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29049971/food-addiction-prevalence-psychopathological-correlates-and-associations-with-quality-of-life-in-a-large-sample
#10
Paulo R Nunes-Neto, Cristiano A Köhler, Felipe B Schuch, Marco Solmi, João Quevedo, Michael Maes, Andrea Murru, Eduard Vieta, Roger S McIntyre, Susan L McElroy, Ashley N Gearhardt, Brendon Stubbs, André F Carvalho
OBJECTIVE: To determine the prevalence of food addiction in a large Brazilian non-clinical sample. Sociodemographic and psychopathological correlates of food addiction as well as associations with quality (QoL) domains were also investigated. METHODS: This cross-sectional study obtained data from a Brazilian anonymous web-based research platform (N = 7639; 71.3% females). Participants provided sociodemographic data and completed the modified Yale Food Addiction Scale 2...
October 12, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29049348/chronic-administration-of-fluoxetine-and-pro-inflammatory-cytokine-change-in-a-rat-model-of-depression
#11
Yanxia Lu, Cyrus S Ho, Xin Liu, Anna N Chua, Wei Wang, Roger S McIntyre, Roger C Ho
This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1β, IL-6, TNF-α and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression. Twenty-four Sprague-Dawley rats were randomly assigned to CMS+vehicle (n = 9), CMS+fluoxetine (n = 9) and the control (n = 6) groups. Sucrose preference and forced swim tests were performed to assess behavioral change...
2017: PloS One
https://www.readbyqxmd.com/read/29028590/efficacy-and-tolerability-of-lisdexamfetamine-as-an-antidepressant-augmentation-strategy-a-meta-analysis-of-randomized-controlled-trials
#12
Peter Giacobbe, Uros Rakita, Raymond Lam, Roumen Milev, Sidney H Kennedy, Roger S McIntyre
BACKGROUND: Psychostimulants have been used in the treatment of depression, with mixed results. This meta-analysis examines the efficacy and tolerability of the stimulant Lisdexamfetamine (LDX) as an add-on strategy in those with MDD who have failed to respond to an antidepressant. METHOD: Randomized control trials were identified and extracted from Pubmed; Web of Science; PsychINFO; and Cochrane Library. The efficacy of LDX was evaluated using Hedges' g and Odds Ratio, whereas Risk Difference was used to assess the safety and tolerability of LDX...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29024974/functional-recovery-in-major-depressive-disorder-providing-early-optimal-treatment-for-the-individual-patient
#13
Oloruntoba J Oluboka, Martin A Katzman, Jeffrey Habert, Diane McIntosh, Glenda M MacQueen, Roumen V Milev, Roger S McIntyre, Pierre Blier
Major depressive disorder (MDD) is an often chronic and recurring illness. Left untreated, MDD may result in progressive alterations in brain morphometry and circuit function. Recent findings, however, suggest that pharmacotherapy may halt and possibly reverse those effects. These findings, together with evidence that a delay in treatment is associated with poorer clinical outcomes, underscore the urgency of rapidly treating depression to full recovery. Early optimized treatment, using measurement-based care and customizing treatment to the individual patient, may afford the best possible outcomes for each patient...
September 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28994900/diagnosing-and-treating-patients-with-mixed-features
#14
Rakesh Jain, Vladimir Maletic, Roger S McIntyre
No abstract text is available yet for this article.
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28992527/sex-differences-in-the-mediators-of-functional-disability-in-major-depressive-disorder
#15
Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Danielle S Cha, Yena Lee, Dominika Fus, Roger S McIntyre
The aim of this study was to investigate sex differences in discrete domains of psychopathology as mediators of functional disability among individuals with Major Depressive Disorder (MDD). Adults (ages 18-65) with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls (HC; n = 100) participated in a clinical trial validating the THINC-integrated tool, a newly developed cognitive assessment tool for patients with MDD. Variables assessed as possible mediators included depression symptom severity, anxiety symptoms, sleep disturbance, perceived cognitive deficits, and objective cognitive performance...
September 30, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28984491/monitoring-for-antidepressant-associated-adverse-events-in-the-treatment-of-patients-with-major-depressive-disorder-an-international-consensus-statement
#16
Seetal Dodd, Philip B Mitchell, Michael Bauer, Lakshmi Yatham, Allan H Young, Sidney H Kennedy, Lana Williams, Trisha Suppes, Carlos Lopez Jaramillo, Madhukar H Trivedi, Maurizio Fava, A John Rush, Roger S McIntyre, Michael E Thase, Raymond W Lam, Emanuel Severus, Siegfried Kasper, Michael Berk
OBJECTIVES: These recommendations were designed to ensure safety for patients with major depressive disorder (MDD) and to aid monitoring and management of adverse effects during treatment with approved antidepressant medications. The recommendations aim to inform prescribers about both the risks associated with these treatments and approaches for mitigating such risks. METHODS: Expert contributors were sought internationally by contacting representatives of key stakeholder professional societies in the treatment of MDD (ASBDD, CANMAT, WFSBP and ISAD)...
October 6, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28972929/risks-of-road-injuries-in-patients-with-bipolar-disorder-and-associations-with-drug-treatments-a-population-based-matched-cohort-study
#17
Vincent Chin-Hung Chen, Yao-Hsu Yang, Chuan-Pin Lee, Jennifer Wong, Lynn Ponton, Yena Lee, Roger S McIntyre, Kuo-You Huang, Shu-I Wu
OBJECTIVE: Using a nation-wide, population-based dataset, we aimed to investigate the risk of road injury among individuals with bipolar disorder (BD) compared to individuals without BD. In addition, we investigated the putative moderating effects of prescription for lithium, anticonvulsants, antidepressants, and/or first- or second-generation antipsychotic agents on the association between BD and risk of road injury. METHOD: As part of an16-year longitudinal cohort study, we compared the risk of road injuries among study subjects aged 16 and above with a diagnosis of BD, with ten age- and sex-matched sample of individuals without BD...
September 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28958785/cognitive-impairment-mediates-workplace-impairment-in-persons-with-type-2-diabetes-mellitus-results-from-the-motivaction-study
#18
Yena Lee, Allan Smofsky, Priscilla Nykoliation, Stephen Allain, Linda Lewis-Daly, Jeremy Schwartz, Joshua Hart Pollack, Jean-Eric Tarride, Roger S McIntyre
OBJECTIVES: Type 2 diabetes mellitus (DM) is associated with substantial impairments in workplace function; however, the mediators of workplace performance in DM are not well characterized. Herein, we investigate depressive symptomatology and cognitive dysfunction as mediators of workplace productivity and hypothesize that workplace impairment is mediated principally by cognitive dysfunction in DM. METHODS: The Motivaction study screened individuals employed across Canada for diabetes...
September 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28958332/protein-phosphatase-inhibitor-1-gene%C3%A2-therapy-in-a-swine-model-of-nonischemic%C3%A2-heart-failure
#19
Shin Watanabe, Kiyotake Ishikawa, Kenneth Fish, Jae Gyun Oh, Lukas J Motloch, Erik Kohlbrenner, Philyoung Lee, Chaoqin Xie, Ahyoung Lee, Lifan Liang, Changwon Kho, Lauren Leonardson, Maritza McIntyre, Scott Wilson, R Jude Samulski, Evangelia G Kranias, Thomas Weber, Fadi G Akar, Roger J Hajjar
BACKGROUND: Increased protein phosphatase-1 in heart failure (HF) induces molecular changes deleterious to the cardiac cell. Inhibiting protein phosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown to reverse cardiac dysfunction in a model of ischemic HF. OBJECTIVES: This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated viral vector carrying I-1c (BNP116.I-1c) in a preclinical model of nonischemic HF, and to assess thoroughly the safety of BNP116...
October 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28944976/obesity-and-frontal-striatal-brain-structures-in-offspring-of-individuals-with-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#20
Rodrigo B Mansur, Roger S McIntyre, Bo Cao, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
OBJECTIVES: To compare frontal-striatal brain volumes between offspring of individuals with bipolar disorder (BD) and healthy controls; to investigate the associations of body mass index (BMI) and age with brain volumes; and to assess the moderating effects of BMI and age on the relationship between risk status and structural brain differences. METHODS: We cross-sectionally assessed structural regional and global brain volumes using magnetic resonance imaging and BMI among 53 BD offspring subjects, stratified by risk status, and 23 non-BD offspring controls (aged 8-28 years)...
September 25, 2017: Bipolar Disorders
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