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Roger McIntyre

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https://www.readbyqxmd.com/read/28501518/cannabidiol-in-medical-marijuana-research-vistas-and-potential-opportunities
#1
REVIEW
Carola Rong, Yena Lee, Nicole E Carmona, Danielle S Cha, Renee-Marie Ragguett, Joshua D Rosenblat, Rodrigo B Mansur, Roger C Ho, Roger S McIntyre
The high and increasing prevalence of medical marijuana consumption in the general population invites the need for quality evidence regarding its safety and efficacy. Herein, we synthesize extant literature pertaining to the phytocannabinoid cannabidiol (CBD) and its brain effects. The principle phytocannabinoid Δ(9)-tetrahydrocannabinol (Δ(9)-THC) and CBD are the major pharmacologically active cannabinoids. The effect of CBD on brain systems as well as on phenomenological measures (e.g. cognitive function) are distinct and in many cases opposite to that of Δ(9)-THC...
May 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28495491/a-computational-algorithm-for-personalized-medicine-in-schizophrenia
#2
Beom S Lee, Roger S McIntyre, James E Gentle, Nan Sook Park, David A Chiriboga, Yena Lee, Sabrina Singh, Marie A McPherson
Despite advances in sequencing candidate genes and whole genomes, no method has accurately predicted who will or will not benefit from a specific antipsychotic medication among patients with schizophrenia. We propose a computational algorithm that utilizes a person-centered approach that directly identifies individual patients who will respond to a specific antipsychotic medication. The algorithm was applied to the data obtained from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study...
May 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28493605/adverse-effects-of-obesity-on-cognitive-functions-in-individuals-at-ultra-high-risk-for-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#3
Roger S McIntyre, Rodrigo B Mansur, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
BACKGROUND: The burden of illness associated with bipolar disorder (BD) warrants early pre-emption/prevention. Prediction models limited to psychiatric phenomenology have insufficient predictive power. Herein, we aimed to evaluate whether the presence of overweight/obesity is associated with greater cognitive decline in individuals at high risk (HR) or ultra high risk (UHR) for BD. METHODS: We conducted a retrospective analysis to investigate the moderational role of body mass index (BMI) on measures of cognitive function...
March 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28482311/tryptophan-breakdown-and-cognition-in-bipolar-disorder
#4
Martina Platzer, Nina Dalkner, Frederike T Fellendorf, Armin Birner, Susanne A Bengesser, Robert Queissner, Nora Kainzbauer, René Pilz, Simone Herzog-Eberhard, Carlo Hamm, Christa Hörmanseder, Alexander Maget, Philipp Rauch, Harald Mangge, Dietmar Fuchs, Sieglinde Zelzer, Gregor Schütze, Natalie Moll, Markus J Schwarz, Rodrigo B Mansur, Roger S McIntyre, Eva Z Reininghaus
INTRODUCTION: It has been demonstrated that bipolar disorder (BD) is often accompanied by cognitive deficits across all subdomains including verbal memory, attention and executive functioning. Cognitive deficits are observed both during episodes of mania or depression, as well as during the euthymic phase. It has been proposed that chronic immune-mediated inflammation in the central nervous system results in alterations in neural structures that subserve cognitive function. Kynurenine is an intermediate in the inflammatory cascade and can be peripherally measured to proxy inflammatory activity...
April 27, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28460574/the-neurogenic-compound-nsi-189-phosphate-a-novel-multi-domain-treatment-capable-of-pro-cognitive-and-antidepressant-effects
#5
Roger S McIntyre, Karl Johe, Carola Rong, Yena Lee
Alterations in neurogenic and neurotrophic processes as well as intracellular signalling cascades provides the basis for hypothesizing that neurogenic agents may be therapeutic across multiple RDoC-defined domains (e.g. positive valence systems, general cognitive processes). Moreover, using the DSM-5 taxonomy, neurogenic agents may mitigate symptoms in adults with depressive and bipolar disorders as well as individuals with cognitive disorders. Areas covered: NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo...
June 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28457001/plasma-copeptin-and-metabolic-dysfunction-in-individuals-with-bipolar-disorder
#6
Rodrigo B Mansur, Lucas B Rizzo, Camila M Santos, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
AIM: This study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relationship between copeptin and metabolic parameters. METHODS: We measured plasma levels of copeptin in individuals with BD (N = 55) and healthy controls (N = 21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28446154/effects-of-escitalopram-and-paroxetine-on-mtorc1-signaling-in-the-rat-hippocampus-under-chronic-restraint-stress
#7
Mi Kyoung Seo, Cheol Min Choi, Roger S McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park, Jung Goo Lee
BACKGROUND: Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs would exert differential effects on mTOR signaling in the rat hippocampus under conditions of chronic restraint stress. Male Sprague-Dawley rats were subjected to restraint stress for 6 h/days for 21 days with either escitalopram (10 mg/kg) or paroxetine (10 mg/kg) administered after the chronic stress procedure...
April 26, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28433459/depressive-disorders-processes-leading-to-neurogeneration-and-potential-novel-treatments
#8
REVIEW
Gregory M Brown, Roger S McIntyre, Joshua Rosenblat, Rüdiger Hardeland
Mood disorders are wide spread with estimates that one in seven of the population are affected at some time in their life (Kessler et al., 2012). Many of those affected with severe depressive disorders have cognitive deficits which may progress to frank neurodegeneration. There are several peripheral markers shown by patients who have cognitive deficits that could represent causative factors and could potentially serve as guides to the prevention or even treatment of neurodegeneration. Circadian rhythm misalignment, immune dysfunction and oxidative stress and circadian rhythm misalignment are key pathologic processes implicated in neurodegeneration and cognitive dysfunction in depressive disorders...
April 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28421980/guidelines-for-the-recognition-and-management-of-mixed-depression
#9
Stephen M Stahl, Debbi A Morrissette, Gianni Faedda, Maurizio Fava, Joseph F Goldberg, Paul E Keck, Yena Lee, Gin Malhi, Ciro Marangoni, Susan L McElroy, Michael Ostacher, Joshua D Rosenblat, Eva Solé, Trisha Suppes, Minoru Takeshima, Michael E Thase, Eduard Vieta, Allan Young, Mark Zimmerman, Roger S McIntyre
A significant minority of people presenting with a major depressive episode (MDE) experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may have important prognostic and treatment implications, the DSM-5 codified a new nosological entity, the "mixed features specifier," referring to individuals meeting threshold criteria for an MDE and subthreshold symptoms of (hypo)mania or to individuals with syndromal mania and subthreshold depressive symptoms. The mixed features specifier adds to a growing list of monikers that have been put forward to describe phenotypes characterized by the admixture of depressive and hypomanic symptoms (e...
February 28, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28410777/evidence-for-neurocognitive-improvement-after-bariatric-surgery-a-systematic-review
#10
REVIEW
Gurneet Thiara, Michela Cigliobianco, Alexei Muravsky, Riccardo A Paoli, Rodrigo Mansur, Raed Hawa, Roger S McIntyre, Sanjeev Sockalingam
BACKGROUND: Bariatric surgery is an effective means of weight reduction in severely obese patients and correlates with improvements in quality of life, mental health outcomes, and neurocognition, especially in those with high psychosocial burden. OBJECTIVE: The primary purpose of this systematic review was to evaluate the impact of bariatric surgery on long-term neurocognitive functioning and neuropsychological outcomes. METHODS: OVID Medline and PsychInfo databases from January 1990 to August 2015 were searched with key terms and phrases: "bariatric surgery" and "cognition...
February 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28384334/correction-the-association-between-methylphenidate-treatment-and-the-risk-for-fracture-among-young-adhd-patients-a-nationwide-population-based-study-in-taiwan
#11
Vincent Chin-Hung Chen, Yao-Hsu Yang, Yin-To Liao, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Tzu-Chin Lin
[This corrects the article DOI: 10.1371/journal.pone.0173762.].
2017: PloS One
https://www.readbyqxmd.com/read/28370311/diagnostic-clusters-associated-with-an-early-onset-schizophrenia-diagnosis-among-children-and-adolescents
#12
Jeanette M Jerrell, Roger S McIntyre, Chelsea B Deroche
OBJECTIVE: Given the greater severity and chronicity of psychiatric disorders that first declare in individuals under the age of 18, early onset schizophrenia (EOS) and its association with co-occurring psychiatric conditions deserve further investigation. METHODS: Cluster and discriminant analyses were used to examine the heterogeneity of children and adolescents diagnosed with schizophrenia in 1 statewide system of care. A retrospective cohort design was employed, using South Carolina's (USA) Medicaid claims dataset covering outpatient and inpatient medical services between January, 1999 and December, 2013 to identify patients ≤17 years of age...
March 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28370310/pharmacotherapy-effectiveness-for-clinical-subgroups-among-children-and-adolescents-with-early-onset-schizophrenia
#13
Jeanette M Jerrell, Roger S McIntyre, Chelsea B Deroche
OBJECTIVE: This study aims to determine the effectiveness of pharmacotherapies among children and adolescents diagnosed with early onset schizophrenia subgrouped according to their co-occurring psychiatric disorders. METHODS: A retrospective cohort design was employed, using South Carolina's (USA) Medicaid claims dataset covering outpatient and inpatient medical services, between January, 1999 and December, 2013 to identify patients ≤17 years of age. Random effects regression analyses assessed differential changes in acute psychiatric service utilization over time across the 3 subgroups associated with antipsychotic, mood stabilizer, psychostimulant, or antidepressant pharmacotherapy...
March 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28350822/asthma-corticosteroid-use-and-schizophrenia-a-nationwide-population-based-study-in-taiwan
#14
Wei-Chen Wang, Mong-Liang Lu, Vincent Chin-Hung Chen, Mei-Hing Ng, Kuo-You Huang, Ming-Hong Hsieh, Meng-Jer Hsieh, Roger S McIntyre, Yena Lee, Charles Tzu-Chi Lee
OBJECTIVE: Asthma and corticosteroid use have been implicated as possible risk factors for schizophrenia. The retrospective cohort study herein aimed to investigate the association between asthma, corticosteroid use, and schizophrenia. METHOD: Longitudinal data (2000 to 2007) from adults with asthma (n = 50,046) and without asthma (n = 50,046) were compared on measures of schizophrenia incidence using Taiwan's National Health Insurance Research Database (NHIRD)...
2017: PloS One
https://www.readbyqxmd.com/read/28338549/reply-to-comments-by-drs-glue-and-menkes
#15
Roger S McIntyre, Yena Lee
No abstract text is available yet for this article.
June 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28296941/the-association-between-methylphenidate-treatment-and-the-risk-for-fracture-among-young-adhd-patients-a-nationwide-population-based-study-in-taiwan
#16
Vincent Chin-Hung Chen, Yao-Hsu Yang, Yin-To Liao, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Tzu-Chin Lin
Attention-deficit hyperactivity disorder (ADHD) is associated with higher risk for fracture. Whether the medical treatment for ADHD would mitigate the risk remains unclear. In this study, we sought to investigate the effect of methylphenidate treatment on risk for fracture, as well the moderational role of treatment duration on the risk of fracture, in a large national sample. Cases less than 18 years old were identified from Taiwan's National Health Insurance Research Database with a new primary diagnosis of ADHD (ICD-9:314) between 1996 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28264727/mixed-features-and-mixed-states-in-psychiatry-from-calculus-to-geometry
#17
Roger S McIntyre
No abstract text is available yet for this article.
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28257449/effects-of-selective-serotonin-reuptake-inhibitors-on-glaucoma-a-nationwide-population-based-study
#18
Vincent Chin-Hung Chen, Mei-Hing Ng, Wei-Che Chiu, Roger S McIntyre, Yena Lee, Tsang-Yaw Lin, Jun-Cheng Weng, Pau-Chung Chen, Chung-Yao Hsu
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are one of the most commonly prescribed classes of antidepressants. Glaucoma is the second leading cause of blindness globally and iatrogenic glaucoma has been implicated across disparate medication classes. Available studies that have sought to determine the association between SSRI exposure and glaucoma have provided mixed results. The aim of the study herein was to investigate whether an association exists between SSRI exposure and glaucoma incidence...
2017: PloS One
https://www.readbyqxmd.com/read/28213943/a-phase-2-safety-study-of-accelerated-elotuzumab-infusion-over-less-than-1-h-in-combination-with-lenalidomide-and-dexamethasone-in-patients-with-multiple-myeloma
#19
James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin
Elotuzumab, an immunostimulatory SLAMF7-targeting monoclonal antibody, induces myeloma cell death with minimal effects on normal tissue. In a previous phase 3 study in patients with relapsed/refractory multiple myeloma (RRMM), elotuzumab (10 mg/kg, ∼3-h infusion), combined with lenalidomide and dexamethasone, demonstrated durable efficacy and acceptable safety; 10% (33/321) of patients had infusion reactions (IRs; Grade 1/2: 29; Grade 3: 4). This phase 2 study (NCT02159365) investigated an accelerated infusion schedule in 70 patients with newly diagnosed multiple myeloma or RRMM...
May 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28107669/medical-comorbidity-in-bipolar-disorder-the-link-with-metabolic-inflammatory-systems
#20
REVIEW
Ana SayuriYamagata, Elisa Brietzke, Joshua D Rosenblat, Ron Kakar, Roger S McIntyre
BACKGROUND: Bipolar disorder (BD) is associated with chronic low-grade inflammation, several medical comorbidities and a decreased life expectancy. Metabolic-inflammatory changes have been postulated as one of the main links between BD and medical comorbidity, although there are few studies exploring possible mechanisms underlying this relationship. Therefore, the aims of the current narrative review were 1) synthesize the evidence for metabolic-inflammatory changes that may facilitate the link between medical comorbidity and BD and 2) discuss therapeutic and preventive implications of these pathways...
March 15, 2017: Journal of Affective Disorders
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