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Roger McIntyre

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https://www.readbyqxmd.com/read/29750035/antidepressant-medication-use-and-nasopharyngeal-cancer-risk-a-nationwide-population-based-study
#1
Chiao-Fan Lin, Hsiang-Lin Chan, Yi-Hsuan Hsieh, Hsin-Yi Liang, Wei-Che Chiu, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
Background: The association between antidepressant exposure and nasopharyngeal cancer (NPC) has not been previously explored. The purpose of this study was to investigate the association between antidepressant prescription, including novel antidepressants, and the risk of NPC in a population-based study. Materials and methods: Data for the analysis were derived from National Health Insurance Research Database. We identified 16,957 cases with a diagnosis of NPC and 83,231 matched controls by using a nested case-control design...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29727072/randomized-controlled-trials-of-psychoeducation-modalities-in-the-management-of-bipolar-disorder-a-systematic-review
#2
See Ann Soo, Zhong Wei Zhang, Sarah Jia'En Khong, Josephine En Wen Low, Vamadevan S/O Thambyrajah, Syed Harun Bin Taha Alhabsyi, Qian Hui Chew, Min Yi Sum, Somnath Sengupta, Eduard Vieta, Roger S McIntyre, Kang Sim
OBJECTIVE: This review sought to summarize the extant literature on the efficacy of 4 modalities of psychoeducation (individual, group, family, internet- based) in the management of patients with bipolar disorder. DATA SOURCES: We searched the digital databases (Science Direct, Scopus, PubMed/MEDLINE) for relevant randomized controlled trials (RCTs) pertaining to psychoeducation in bipolar disorder from inception to February 2017. Keywords and combinations used included psychoeducation, bipolar disorder, individual, family, group, and internet...
May 1, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29723856/are-antidepressants-harmful-in-the-general-population
#3
Joshua D Rosenblat, Sarah Smith, Roger S McIntyre
No abstract text is available yet for this article.
May 3, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29705533/association-between-enterovirus-infection-and-speech-and-language-impairments-a-nationwide-population-based-study
#4
Tai-Hsin Hung, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ching-Shu Tsai, Mong-Liang Lu, Roger S McIntyre, Yena Lee, Kuo-You Huang
BACKGROUND AND AIMS: Delay and impairment in Speech and language are common developmental problems in younger populations. Hitherto, there has been minimal study of the association between common childhood infections (e.g. enterovirus [EV]) and speech and language. The impetus for evaluating this association is provided by evidence linking inflammation to neurodevelopmental disorders. Herein we sought to determine whether an association exists between EV infection and subsequent diagnoses of speech and language impairments in a nationwide population-based sample in Taiwan...
April 26, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29701669/differentiating-medicated-patients-suffering-from-major-depressive-disorder-from-healthy-controls-by-spot-urine-measurement-of-monoamines-and-steroid-hormones
#5
Chandra S Wijaya, Jovia J Z Lee, Syeda F Husain, Cyrus S H Ho, Roger S McIntyre, Wilson W Tam, Roger C M Ho
Introduction : Major Depressive Disorder (MDD) is a common psychiatric disorder. Currently, there is no objective, cost-effective and non-invasive method to measure biological markers related to the pathogenesis of MDD. Previous studies primarily focused on urinary metabolite markers which are not proximal to the pathogenesis of MDD. Herein, we compare urinary monoamines, steroid hormones and the derived ratios amongst MDD when compared to healthy controls. Methods : Morning urine samples of medicated patients suffering from MDD ( n = 47) and healthy controls ( n = 41) were collected...
April 26, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29689697/prostate-cancer-and-antidepressants-a-nationwide-population-based-nested-case-control-study
#6
Wei-Yu Lin, Vincent Chin-Hung Chen, Wei-Che Chiu, Samantha J Yim, Peter T Ho, Roger S McIntyre, Mong-Liang Lu, Shui-I Wu
BACKGROUND: We aimed to evaluate the association between antidepressant and prostate cancer by comparing exposures to antidepressants between those with and without prostate cancer. METHODS: A nationwide insurance claims database was used to identify our case subjects. Age- and gender-matched controls were selected at a 1:5 ratio. Conditional logistic regression model was used. RESULTS: 11,515 patients with prostate cancer were identified and matched with 55,373 controls...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29689693/vortioxetine-improves-symptomatic-and-functional-outcomes-in-major-depressive-disorder-a-novel-dual-outcome-measure-in-depressive-disorders
#7
Michael Cronquist Christensen, Henrik Loft, Roger S McIntyre
BACKGROUND: With symptomatic remission and functional recovery as the overarching therapeutic objectives of antidepressant therapy, composite endpoint measures that conjointly consider both aspects of treatment are needed. This analysis evaluated the combined effect of vortioxetine on depressive symptoms and functional capacity in adults with MDD. METHODS: NCT01564862, a multinational, double-blind, placebo-controlled, duloxetine-referenced study, conducted between April 2012 and February 2014, in 602 adult outpatients (18-65 years) with moderate-to-severe MDD (Montgomery-Åsberg Depression Rating Scale (MADRS) ≥ 26), a major depressive episode of ≥ 3 months' duration, and self-reported cognitive symptoms were randomized to once-daily vortioxetine (10 or 20mg), duloxetine (60mg), or placebo for 8 weeks...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29680575/the-impact-of-body-mass-index-in-gene-expression-of-reelin-pathway-mediators-in-individuals-with-schizophrenia-and-mood-disorders-a-post-mortem-study
#8
Elisa Brietzke, Alisson P Trevizol, Gabriel R Fries, Mehala Subramaniapillai, Flavio Kapczinski, Roger S McIntyre, Rodrigo B Mansur
The objective of this study was to compare the expression of genes involved in the reelin pathway, in the post-mortem brain of individuals with schizophrenia (SZ) and mood disorders (MD) with a healthy control (HC) group; and to investigate the role f body mass index (BMI) as a potential mediator. The "Gene Expression in Postmortem dlPFC and Hippocampus from Schizophrenia and Mood Disorders" study holds microarray data on individuals with SZ, MD and HCs (from whom 849 specimens are from the dlPFC and 579 from the hippocampus)...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29673146/predictors-of-response-to-ketamine-in-treatment-resistant-major-depressive-disorder-and-bipolar-disorder
#9
Carola Rong, Caroline Park, Joshua D Rosenblat, Mehala Subramaniapillai, Hannah Zuckerman, Dominika Fus, Yena L Lee, Zihang Pan, Elisa Brietzke, Rodrigo B Mansur, Danielle S Cha, Leanna M W Lui, Roger S McIntyre
OBJECTIVES: Extant evidence indicates that ketamine exerts rapid antidepressant effects in treatment-resistant depressive (TRD) symptoms as a part of major depressive disorder (MDD) and bipolar disorder (BD). The identification of depressed sub-populations that are more likely to benefit from ketamine treatment remains a priority. In keeping with this view, the present narrative review aims to identify the pretreatment predictors of response to ketamine in TRD as part of MDD and BD. METHOD: Electronic search engines PubMed/MEDLINE, ClinicalTrials...
April 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29660754/antidepressant-prescription-and-risk-of-lung-cancer-a-nationwide-case-control-study
#10
Chia-Jui Tsai, Wei-Che Chiu, Chia-Ju Chen, Pau-Chung Chen, Roger S McIntyre, Vincent Chin-Hung Chen
INTRODUCTION: In recent decades, concern about safety of antidepressants has been raised but the risk between antidepressants and lung cancer has not yet been established. METHODS: A case-control study was conducted by using a nationwide database in Taiwan. The case groups were new onset lung cancer diagnosis during 1999-2008 and age- and gender-matched controls were selected among those without any cancer. The cumulative exposure dose before the lung cancer diagnosis was added and risks were calculated according to the levels of defined daily dose and classes of antidepressants...
April 16, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29621905/pharmacodynamic-and-pharmacokinetic-evaluation-of-buprenorphine-samidorphan-for-the-treatment-of-major-depressive-disorder
#11
Renee-Marie Ragguett, Carola Rong, Joshua D Rosenblat, Roger C Ho, Roger S McIntyre
Treatment resistant depression (TRD) represents approximately 20% of all individuals receiving care for major depressive disorder. The opioidergic system is identified as a novel target which hitherto has not been sufficiently investigated in adults with TRD. The combination product buprenorphine + samidorphan is an opioid modulatory agent which has demonstrated replicated evidence of efficacy in TRD without abuse liability. Areas covered: Databases Pubmed, Google Scholar and clinicaltrials.gov were searched from inception through December 2017 for clinical trial information, pharmacokinetics, and pharmacodynamics of buprenorphine + samidorphan...
April 6, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29555342/effectiveness-of-a-type-2-diabetes-screening-intervention-in-the-canadian-workplace
#12
Jean-Eric Tarride, Allan Smofsky, Priscilla Nykoliation, Stephen Allain, Linda Lewis-Daly, David Satok, Jeremy Schwartz, Joshua Hart Pollack, Jason Robert Guertin, Roger S McIntyre
OBJECTIVES: There is a lack of Canadian data concerning the effectiveness of diabetes interventions in the workplace. The objective of this study was to evaluate the effectiveness of Motivaction, a diabetes screening and education pilot program, in the workplace. METHODS: The Motivaction program involves a voluntary web-based diabetes health-risk assessment, the Canadian Diabetes Risk Questionnaire (CANRISK), combined with an opportunity for those eligible (i.e...
December 18, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29536616/canadian-network-for-mood-and-anxiety-treatments-canmat-and-international-society-for-bipolar-disorders-isbd-2018-guidelines-for-the-management-of-patients-with-bipolar-disorder
#13
Lakshmi N Yatham, Sidney H Kennedy, Sagar V Parikh, Ayal Schaffer, David J Bond, Benicio N Frey, Verinder Sharma, Benjamin I Goldstein, Soham Rej, Serge Beaulieu, Martin Alda, Glenda MacQueen, Roumen V Milev, Arun Ravindran, Claire O'Donovan, Diane McIntosh, Raymond W Lam, Gustavo Vazquez, Flavio Kapczinski, Roger S McIntyre, Jan Kozicky, Shigenobu Kanba, Beny Lafer, Trisha Suppes, Joseph R Calabrese, Eduard Vieta, Gin Malhi, Robert M Post, Michael Berk
The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments...
March 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29505194/cognitive-impairment-in-major-depressive-disorder-a-case-discussion-illustrating-impact-assessment-and-management
#14
Larry Culpepper, Raymond W Lam, Roger S McIntyre
How can you help your patients who are experiencing both depression and cognitive dysfunction? Tune in to this CME podcast to hear experts in psychiatry discuss 2 patient cases that illustrate the burden of cognitive impairment in major depressive disorder as well as effective assessment tools and management strategies.
January 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29505192/improving-remission-rates-in-major-depressive-disorder-a-case-based-approach
#15
Roger S McIntyre
How many of your patients achieve remission from depression with their first treatment? In this CME Health Spectrum activity, enter a virtual office to follow 2 patient cases about inadequate response to treatment. Learn as an expert describes strategies based on recent evidence-based guidelines.
January 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29501551/the-relationship-of-depression-with-the-level-of-blood-pressure-in-population-based-kangbuk-samsung-health-study
#16
Sung Keun Park, Ju Young Jung, Jae-Hong Ryoo, Chang-Mo Oh, Jae-Hon Lee, Zihang Pan, Rodrigo B Mansur, Margarita Shekotikhina, Roger S McIntyre, Joong-Myung Choi
There has been increasing evidence about psychosomatic relationship between mood disorder and blood pressure (BP). However, the degree to which BP categories are associated with depression has been less well described. Thus, this study was to investigate the association of depression with BP categories. A total of 90,643 men and 68,933 women were enrolled in this study. They were stratified into four groups (normal, prehypertension, newly diagnosed hypertension, and recognized hypertension) according to the BP levels and the history of hypertension...
May 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29481915/cognitive-dysfunction-and-metabolic-comorbidities-in-mood-disorders-a-repurposing-opportunity-for-glucagon-like-peptide-1-receptor-agonists
#17
REVIEW
Rodrigo B Mansur, Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Roger S McIntyre
Major depressive disorder and bipolar disorder are highly prevalent and disabling conditions. Cognition is considered a core domain of their psychopathology and a principle mediator of psychosocial impairment, disproportionately accounting for overall illness-associated costs. There are few interventions with replicated evidence of efficacy in treating cognitive deficits in mood disorders. Evidence also indicates that cognitive deficits are associated with obesity and involve significant impairment across multiple domains...
February 23, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29474648/an-integrated-quantitative-index-for-measuring-chronic-multisite-pain-the-multiple-areas-of-pain-map-study
#18
Mark S Wallace, James North, Eric J Grigsby, Leonardo Kapural, Mahendra R Sanapati, Stephen G Smith, Channing Willoughby, Patrick J McIntyre, Steven P Cohen, Richard M Rosenthal, Shaik Ahmed, Ricardo Vallejo, Farshad M Ahadian, Thomas L Yearwood, Allen W Burton, Edward J Frankoski, Jai Shetake, Sherry Lin, Brad Hershey, Benjamin Rogers, Nitzan Mekel-Bobrov
Objective: Despite the high prevalence of chronic multisite pain, there is little consensus on methods to characterize it. Commonly used assessments report only one dimension of pain, that is, intensity, thus ignoring the spatial aspect of pain. We developed a novel pain quantification index, the Integrated Pain Quantification Index (IPQI), on a scale of 0 to 1 that integrates multiple distinct pain measures into a single value, thus representing multidimensional pain information with a single value...
February 21, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29433074/the-relationship-between-inflammatory-state-and-quantity-of-affective-episodes-in-bipolar-disorder
#19
Robert Queissner, René Pilz, Nina Dalkner, Armin Birner, Susanne A Bengesser, Martina Platzer, Frederike T Fellendorf, Nora Kainzbauer, Simone Herzog-Eberhard, Carlo Hamm, Bernd Reininghaus, Sieglinde Zelzer, Harald Mangge, Rodrigo B Mansur, Roger S McIntyre, Hans-Peter Kapfhammer, Eva Z Reininghaus
OBJECTIVES: Immunological/inflammatory processes have been proposed to play an important role in the pathophysiology of mood disorders, including bipolar disorder (BD). The present study aimed to examine the influence of immune activation, measured on the basis of inflammatory markers, on the course of illness, proxied by the number of affective episodes, in patients with BD. METHODS: We investigated the relationship between high-sensitive CRP (hsCRP) and Interleukin 6 (IL-6), two inflammatory markers and characteristics of course of illness (e...
April 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29427512/the-use-of-brexpiprazole-amongst-individuals-with-insufficient-outcomes-with-aripiprazole-or-bupropion-a-case-series
#20
Traci Aladeen, Erica Westphal, Yena Lee, Carola Rong, Michelle Rainka, Horacio Capote, Roger S McIntyre
PURPOSE: We sought to characterize the clinical experience of outpatients treated with brexpiprazole after achieving suboptimal outcomes with aripiprazole or bupropion as determined by the treating psychiatric provider. DESIGN AND METHODS: Case series; inefficacy, intolerability, or other unsatisfactory outcome to previous trial with aripiprazole or bupropion. FINDINGS: The majority of individuals in our sample exhibited tolerability of brexpiprazole...
February 10, 2018: Perspectives in Psychiatric Care
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