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https://www.readbyqxmd.com/read/28105526/first-versus-second-year-respiratory-syncytial-virus-prophylaxis-in-chronic-lung-disease-2005-2015
#1
Daniel Y Wang, Abby Li, Bosco Paes, Ian Mitchell, Krista L Lanctôt
: Children aged <2 years with chronic lung disease (CLD) have a 10-fold higher risk for respiratory syncytial virus-positive hospitalization (RSVH) compared to healthy term infants. Based on the updated position statements, we compared respiratory-related illness hospitalization (RIH) and RSVH risks in CLD children who received palivizumab during the first year (FY) versus second year (SY) of life in the Canadian Registry of Palivizumab (CARESS). Demographic data were collected at enrolment and RIH events recorded monthly from 2005 to 2015...
January 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28089687/stabilizing-effects-for-antibody-formulations-and-safety-profiles-of-cyclodextrin-polypseudorotaxane-hydrogels
#2
Taishi Higashi, Naoko Ohshita, Tatsunori Hirotsu, Yoshihito Yamashita, Keiichi Motoyama, Sawako Koyama, Ruriko Iibuchi, Takayuki Uchida, Shiuhei Mieda, Kenji Handa, Tomoaki Kimoto, Hidetoshi Arima
Antibodies often have poor physicochemical stability during storage and/or transport, which is a serious drawback for the development of antibody-based drugs. In this study, we prepared polypseudorotaxane (PPRX) hydrogels consisting of cyclodextrins (CyDs) and polyethylene glycol (PEG), and evaluated them as stabilizers for commercially available antibody-based drugs. α-CyD and γ-CyD formed PPRX hydrogels with PEG (MW 20,000 Da) in the presence of antibody-based drugs such as omalizumab, palivizumab, panitumumab, and ranibizumab...
January 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28078558/respiratory-syncytial-virus-associated-hospitalizations-in-preterm-infants-of-29-to-32%C3%A2-weeks-gestational-age-using-a-risk-score-tool-for-palivizumab-prophylaxis
#3
B Resch, V S Bramreiter, S Kurath-Koller, T Freidl, B Urlesberger
To evaluate the efficacy of palivizumab in infants of 29 to 32 weeks of gestational age (GA) based on a risk score tool developed for Austria. Retrospective single-center cohort study including all preterm infants of 29 (+0) to 32 (+6) weeks of GA born between 2004 and 2012 at a tertiary care university hospital. Data on RSV-related hospitalizations over the first 2 years of life were analyzed and compared between those having received palivizumab and those without. The study population was comprised of 789 of 816 screened infants, of whom 262 (33%) had received palivizumab and 527 (67%) had not...
January 11, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28005688/respiratory-syncytial-virus-infection-associated-hospitalization-rates-in-infants-and-children-with-cystic-fibrosis
#4
Jakob Metz, Ernst Eber, Bernhard Resch
BACKGROUND: Infections with respiratory syncytial virus (RSV) are the leading cause for hospital admissions in infants and young children. The incidence of RSV-related hospitalizations in patients with cystic fibrosis (CF) is unclear. To date no effective treatment for RSV infections is available. Thus, prophylaxis with the monoclonal antibody palivizumab is an important option. METHODS: In a retrospective, single-center study at the Department of Paediatrics and Adolescent Medicine of the Medical University Graz, Austria, we analyzed all CF patients born between 1995 and 2012, who were admitted for respiratory problems between 1995 and 2014...
December 21, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27989627/development-of-bioluminescence-imaging-of-respiratory-syncytial-virus-rsv-in-virus-infected-live-mice-and-its-use-for-evaluation-of-therapeutics-and-vaccines
#5
Sandra Fuentes, Diego Arenas, Martin M Moore, Hana Golding, Surender Khurana
Respiratory Syncytial virus (RSV) is one of the leading causes of pneumonia among infants with no human vaccine or efficient curative treatments. Efforts are underway to develop new RSV vaccines and therapeutics. There is a dire need for animal models for preclinical evaluation and selection of products against RSV. Herein, we developed a whole body bioluminescence imaging to follow replication of RSV A2 virus strain expressing firefly luciferase (RSVA2-line19-FFL) in live BALB/c mice that can be used as an extremely sensitive readout for studying effects of antiviral and vaccines in living mice...
December 15, 2016: Vaccine
https://www.readbyqxmd.com/read/27956428/safety-tolerability-and-pharmacokinetics-of-the-respiratory-syncytial-virus-prefusion-f-targeting-monoclonal-antibody-with-an-extended-half-life-medi8897-in-healthy-adults
#6
M Pamela Griffin, Anis A Khan, Mark T Esser, Kathryn Jensen, Therese Takas, Martin K Kankam, Tonya Villafana, Filip Dubovsky
Prevention of respiratory syncytial virus (RSV) illness in infants is a major public health priority, but there is no approved vaccine. Palivizumab is a monoclonal antibody that provides RSV prophylaxis but requires 5 monthly injections and is approved only for infants who experience the greatest morbidity and mortality from RSV. Thus, there remains a significant unmet medical need for prevention of RSV disease in healthy infants. MEDI8897 is a recombinant human RSV monoclonal antibody with a modified Fc region that extends its half-life and is being developed as RSV prophylaxis for all infants...
December 12, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27941187/factors-related-to-compliance-with-palivizumab-prophylaxis-for-respiratory-syncytial-virus-rsv-infection-data-from-poland
#7
Róża Borecka, Ryszard Lauterbach, Ewa Helwich
AIM: To evaluate compliance and health outcomes in children receiving palivizumab prophylaxis and to identify factors that could impact parental compliance with the recommended regimen of palivizumab immunoprophylaxis. MATERIAL AND METHODS: A retrospective, multicentre, non-interventional study of children enrolled in the Polish National Programme for Respiratory Syncytial Virus (RSV) Immunoprophylaxis who received ≥1 dose of palivizumab during two consecutive RSV seasons (I: 2008-2009, II: 2009-2010)...
2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27926583/evaluation-of-the-financial-and-health-burden-of-infants-at-risk-for-respiratory-syncytial-virus
#8
Stephanie McCallum Blake, David Tanaka, Lisa M Bendz, Suzanne Staebler, Debra Brandon
BACKGROUND: Respiratory syncytial virus (RSV) is the leading viral cause of death in infants younger than 1 year. In July 2014, the American Academy of Pediatrics (AAP) Committee on Infectious Diseases concluded that the "limited clinical benefit" for infants born at more than 29 weeks' gestation, together with the associated high cost of the immunoprophylaxis, no longer supported the routine use of palivizumab (Synagis). PURPOSE: To evaluate the impact of the newly adopted AAP palivizumab prophylaxis administration on health and subsequent hospital costs of infants born between 29 and less than 32 weeks' gestation...
December 6, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27919877/pharmacist-driven-respiratory-syncytial-virus-prophylaxis-stewardship-service-in-a-neonatal-intensive-care-unit
#9
Sara E Rostas, Christopher McPherson
PURPOSE: The development and implementation of a pharmacist-driven respiratory syncytial virus (RSV) prophylaxis stewardship program in a neonatal intensive care unit (NICU) are described. SUMMARY: An RSV prophylaxis stewardship service was created in the NICU at Brigham and Women's Hospital to align with the newly updated 2014 American Academy of Pediatrics (AAP) recommendations for palivizumab. The service comprised two NICU clinical pharmacists with oversight from the NICU medical director and the chair of the NICU infection control committee...
December 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27855996/impact-of-the-updated-guidance-for-palivizumab-prophylaxis-against-respiratory-syncytial-virus-infection-a-single-center-experience
#10
Bavani Rajah, Pablo J Sánchez, Cristina Garcia-Maurino, Amy Leber, Octavio Ramilo, Asuncion Mejias
OBJECTIVES: To determine the differences in number of respiratory syncytial virus (RSV) hospitalizations and outcomes in infants 29(0/7)-34(6/7) weeks' gestational age (wGA) the season before (season 1 [S1]; 2013-2014) and after (season 2 [S2]; 2014-2015) implementation of the 2014 American Academy of Pediatrics revised guidance for palivizumab prophylaxis. STUDY DESIGN: Children <12 months of age hospitalized with RSV infection were identified by the International Classification of Diseases, Ninth Revision codes and virology reports...
November 15, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27791117/structural-basis-for-nonneutralizing-antibody-competition-at-antigenic-site-ii-of-the-respiratory-syncytial-virus-fusion-protein
#11
Jarrod J Mousa, Marion F Sauer, Alexander M Sevy, Jessica A Finn, John T Bates, Gabriela Alvarado, Hannah G King, Leah B Loerinc, Rachel H Fong, Benjamin J Doranz, Bruno E Correia, Oleksandr Kalyuzhniy, Xiaolin Wen, Theodore S Jardetzky, William R Schief, Melanie D Ohi, Jens Meiler, James E Crowe
Palivizumab was the first antiviral monoclonal antibody (mAb) approved for therapeutic use in humans, and remains a prophylactic treatment for infants at risk for severe disease because of respiratory syncytial virus (RSV). Palivizumab is an engineered humanized version of a murine mAb targeting antigenic site II of the RSV fusion (F) protein, a key target in vaccine development. There are limited reported naturally occurring human mAbs to site II; therefore, the structural basis for human antibody recognition of this major antigenic site is poorly understood...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27768505/the-cost-effectiveness-of-palivizumab-in-infants-with-cystic-fibrosis-in-the-canadian-setting-a-decision-analysis-model
#12
Ashleigh A McGirr, Kevin L Schwartz, Upton Allen, Melinda Solomon, Beate Sander
BACKGROUND: Children with cystic fibrosis (CF) are at higher risk of severe respiratory syncytial virus (RSV) infection, which can lead to a decline in lung function. A monoclonal antibody, palivizumab (PMB), effectively prevents RSV hospitalizations; however, the high cost of PMB, approximately C$10,000 per patient per RSV season, limits its widespread use. We assess the cost-effectiveness of PMB prophylaxis in CF children less than 2 y of age from the Canadian healthcare payer's perspective...
October 21, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27753795/comparing-first-and-second-year-palivizumab-prophylaxis-in-patients-with-hemodynamically-significant-congenital-heart-disease-in-the-caress-database-2005-2015
#13
Abby Li, Daniel Y Wang, Krista L Lanctôt, Ian Mitchell, Bosco A Paes
BACKGROUND: Respiratory syncytial virus hospitalization (RSVH) rates in children less than <2 years of age with hemodynamically significant congenital heart disease (HSCHD) are 2-4 fold higher compared with healthy term infants. Pediatric recommendations differ as to whether palivizumab is beneficial beyond 1 year of age. The objective was to determine whether differences exist in respiratory-related illness hospitalization (RIH) and RSVH in HSCHD infants receiving palivizumab during the first year versus second year of life in the Canadian Registry of Palivizumab (CARESS)...
October 6, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27721865/retrospective-multicenter-study-of-respiratory-syncytial-virus-prophylaxis-in-korean-children-with-congenital-heart-diseases
#14
Ah Young Kim, Se Yong Jung, Jae Young Choi, Gi Beom Kim, Young-Hwue Kim, Woo Sup Shim, I-Seok Kang, Jo Won Jung
BACKGROUND AND OBJECTIVES: We conducted a review of current data on respiratory syncytial virus (RSV) prophylaxis with palivizumab, in Korean children with congenital heart diseases (CHD). In 2009, the Korean guideline for RSV prophylaxis had established up to five shots monthly per RSV season, only for children <1 year of age with hemodynamic significance CHD (HS-CHD). SUBJECTS AND METHODS: During the RSV seasons in 2009-2015, we performed a retrospective review of data for 466 infants with CHD, examined at six centers in Korea...
September 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27704018/insurance-status-and-the-risk-of-severe-respiratory-syncytial-virus-disease-in-united-states-preterm-infants-born-at-32-35-weeks-gestational-age
#15
Jeremy A Franklin, Evan J Anderson, Xionghua Wu, Christopher S Ambrose, Eric A F Simões
Background.  Database studies have identified that public health insurance status is associated with an increased risk of severe respiratory syncytial virus (RSV) disease in US infants. However, these studies did not adjust for the presence of other risk factors and did not evaluate the risk in preterm infants. Methods.  In this study, we evaluate the independent association between public insurance and severe RSV disease outcomes adjusting for other risk factors. The prospective, observational RSV Respiratory Events among Preterm Infants Outcomes and Risk Tracking (REPORT) study was conducted over 2 consecutive RSV seasons at 188 US clinical sites that enrolled preterm infants born at 32-35 wGA who had not received RSV immunoprophylaxis with palivizumab...
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27692523/development-and-clinical-applications-of-novel-antibodies-for-prevention-and-treatment-of-respiratory-syncytial-virus-infection
#16
Asuncion Mejias, Cristina Garcia-Maurino, Rosa Rodriguez-Fernandez, Mark E Peeples, Octavio Ramilo
Respiratory syncytial virus (RSV) remains a significant cause of morbidity and mortality in infants and young children, immunocompromised patients and the elderly. Despite the high disease burden, an effective and safe vaccine is lacking, although several candidates are currently in development. Current treatment for RSV infection remains largely supportive and RSV-specific options for prophylaxis are limited to palivizumab. In the past few years, novel therapeutic options including nanobodies, polyclonal and monoclonal antibodies have emerged and there are several products in preclinical and Phase-I, -II or -III clinical trials...
January 11, 2017: Vaccine
https://www.readbyqxmd.com/read/27665287/palivizumab-exposure-and-the-risk-of-autoimmune-disease-a-cross-national-cohort-study
#17
Ann Haerskjold, Marie Linder, Lonny Henriksen, Simon Francis Thomsen, Helle Kieler, Henrik Ravn, Lone Graff Stensballe
BACKGROUND: Treatment with biologic pharmaceuticals may be associated with an increased risk of immune-mediated disease. Palivizumab is a humanized monoclonal antibody designed to provide passive immunity against respiratory syncytial virus infection. Palivizumab is primarily used in preterm children known to be immunologically immature. The long-term effect of palivizumab in terms of autoimmune diseases has not yet been investigated. AIM: Our objective was to investigate whether exposure to palivizumab was associated with the development of autoimmune diseases in children...
December 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27649365/outcomes-of-infants-receiving-palivizumab-prophylaxis-for-respiratory-syncytial-virus-in-canada-and-italy-an-international-prospective-cohort-study
#18
Paolo Manzoni, Bosco Paes, Krista L Lanctôt, Alberto Dall'Agnola, Ian Mitchell, Sara Calabrese, Milena Maule, Elisa Girardi, Tetsuhiro Harimoto, Abby Li
BACKGROUND: Respiratory syncytial virus (RSV) infection frequently results in RSV-related hospitalization (RSVH) in young infants. We examined the outcomes of palivizumab recipients within the Canadian Registry (CARESS) and the Torino-Verona Italian Registry over the 2002-2014 RSV seasons. METHODS: RSVHs were captured during the study seasons. Premature infants who received palivizumab (≤35 completed weeks' gestational age; group1) were compared with infants given palivizumab for underlying disorders regardless of gestational age (group 2)...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27618642/consensus-conference-on-the-appropriateness-of-palivizumab-prophylaxis-in-respiratory-syncytial-virus-disease
#19
REVIEW
Maria Serenella Pignotti, Maria Carmela Leo, Alessandra Pugi, Salvatore De Masi, Klaus Peter Biermann, Luisa Galli, Giovanni Vitali Rosati, Giuseppe Buonocore, Alessandro Mugelli, Carlo Dani, Ersilia Lucenteforte, Francesca Bellini, Giampaolo Donzelli
Respiratory syncytial virus infection represents a clinical burden among young children under 24 months. Palivizumab is the only drug licensed in Italy for the prevention of serious lower respiratory tract disease requiring hospitalization caused by respiratory syncytial virus in children at high risk. However recommendations for palivizumab prophylaxis are heterogeneous. Not all the published documents agree about the clinical indications of palivizumab; this could lead to different clinical practices and concerns about the appropriateness of prophylaxis...
October 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27598776/prevention-of-syncytial-respiratory-virus-infection-with-palivizumab-descriptive-and-comparative-analysis-after-12-years-of-use
#20
Eduardo Narbona-Lopez, Jose Uberos, Ana Checa-Ros, Rocio Rodriguez-Belmonte, Antonio Muñoz-Hoyos
BACKGROUND: The use of Palivizumab has been recommended to prevent Syncytial Respiratory Virus infection in vulnerable children. METHODS: We performed a retrospective study of hospital admissions for bronchiolitis from 2000 to 2012 in the context of a prevention study with Palivizumab in at-risk newborns. RESULTS: A total of 952 children (59.5% males) were admitted due to bronchiolitis. Admissions occurred in younger children in the SRV+ cases compared to the SRV- cases (p < 0...
September 6, 2016: Minerva Pediatrica
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