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https://www.readbyqxmd.com/read/28645202/effects-of-mobility-and-multimorbidity-on-inpatient-and-post-acute-health-care-utilization
#1
Kristine E Ensrud, Li-Yung Lui, Lisa Langsetmo, Tien N Vo, Brent C Taylor, Peggy M Cawthon, Meredith L Kilgore, Charles E McCulloch, Jane A Cauley, Marcia L Stefanick, Kristine Yaffe, Eric S Orwoll, John T Schousboe
Background: This study examines effects of mobility and multimorbidity on hospitalization and inpatient and post-acute care (PAC) facility days among older men. Methods: Prospective study of 1701 men (mean age 79.3 years) participating in MrOS Study Year 7 (Y7) examination (2007-2008) linked with their Medicare claims. At Y7, mobility ascertained by usual gait speed and categorized as poor, intermediate, or good. Multimorbidity quantified by applying Elixhauser algorithm to inpatient and outpatient claims and categorized as none, mild-moderate, or high...
June 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28645197/pht%C3%AE-promoted-mobilization-of-non-conjugative-resistance-plasmids-from-enterococcus-faecium-to-enterococcus-faecalis
#2
Laura Di Sante, Gianluca Morroni, Andrea Brenciani, Carla Vignaroli, Alberto Antonelli, Marco Maria D'Andrea, Andrea Di Cesare, Eleonora Giovanetti, Pietro E Varaldo, Gian Maria Rossolini, Francesca Biavasco
Objectives: : To analyse the recombination events associated with conjugal mobilization of two multiresistance plasmids, pRUM 17i48 and pLAG (formerly named pDO1-like), from Enterococcus faecium 17i48 to Enterococcus faecalis JH2-2. Methods: : The plasmids from two E. faecalis transconjugants (JH-4T, tetracycline resistant, and JH-8E, erythromycin resistant) and from the E. faecium donor (also carrying a pHTβ-like conjugative plasmid, named pHTβ 17i48 ) were investigated by several methods, including PCR mapping and sequencing, S1-PFGE followed by Southern blotting and hybridization, and WGS...
June 22, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28645177/mobile-genetic-elements-in-neisseria-gonorrhoeae-movement-for-change
#3
Ana Cehovin, Steven B Lewis
Neisseria gonorrhoeae, the causative agent of the sexually transmitted disease gonorrhoeae, possesses several mobile genetic elements (MGEs). The MGEs such as transposable elements mediate intra-chromosomal rearrangements, while plasmids and the gonococcal genetic island are involved in inter-chromosomal gene transfer. Additionally, gonococcal MGEs serve as hotspots for recombination and integration of other genetic elements such as bacteriophages, contribute to gene regulation or spread genes through gonococcal populations by horizontal gene transfer...
June 22, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28645093/identification-of-key-outcome-measures-when-using-the-instrumented-timed-up-and-go-and-or-posturography-for-fall-screening
#4
Renee Beach Sample, Allison L Kinney, Kurt Jackson, Wiebke Diestelkamp, Kimberly Edginton Bigelow
The Timed Up and Go (TUG) has been commonly used for fall risk assessment. The instrumented Timed Up and Go (iTUG) adds wearable sensors to capture sub-movements and may be more sensitive. Posturography assessments have also been used for determining fall risk. This study used stepwise logistic regression models to identify key outcome measures for the iTUG and posturography protocols. The effectiveness of the models containing these measures in differentiating fallers from non-fallers were then compared for each: iTUG total time duration only, iTUG, posturography, and combined iTUG and posturography assessments...
June 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28645085/extending-the-functionality-of-the-slurry-ferrihydrite-dgt-method-performance-evaluation-for-the-measurement-of-vanadate-arsenate-antimonate-and-molybdate-in-water
#5
Shu Zhang, Paul N Williams, Chun-Yang Zhou, Lena Q Ma, Jun Luo
The monitoring of oxyanions in waters, presents significant challenges due to their relatively low concentrations, and a characteristically changeable/unstable/reactive geochemistry with high spatial and temporal turnover. This results in a very heterogeneous pattern of mobility and bioavailability, which is difficult to capture reliably and in a cost effective manner. The diffusive gradients in thin-films (DGT) technique is a popular analytical tool for testing water quality, primarily because it provides a time-integrated measurement...
June 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28645067/using-a-detailed-inventory-of-a-large-wastewater-treatment-plant-to-estimate-the-relative-importance-of-construction-to-the-overall-environmental-impacts
#6
Serni Morera, Lluís Corominas, Miquel Rigola, Manel Poch, Joaquim Comas
The aim of this work is to quantify the relative contribution to the overall environmental impact of the construction phase compared to the operational phase for a large conventional activated sludge wastewater treatment plant (WWTP). To estimate these environmental impacts, a systematic procedure was designed to obtain the detailed Life Cycle Inventories (LCI) for civil works and equipment, taking as starting point the construction project budget and the list of equipment installed at the Girona WWTP, which are the most reliable information sources of materials and resources used during the construction phase...
June 2, 2017: Water Research
https://www.readbyqxmd.com/read/28645034/formation-of-hematite-nanoparticle-monolayers-of-controlled-coverage-and-structure-at-polymeric-microparticles
#7
Marta Sadowska, Zbigniew Adamczyk, Małgorzata Nattich-Rak
The deposition of hematite nanoparticles (22nm and 29nm in diameter) on negatively charged polystyrene microspheres (820nm in diameter) was studied by micro-electrophoretic measurements and AFM. The influence of ionic strength, varied between 10(-4) and 10(-2)M, was determined. Initially, the electrophoretic mobility change of microspheres upon the addition of controlled amount of hematite nanoparticles were measured. These dependencies were quantitatively interpreted in terms of the general electrokinetic model...
June 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28645029/phytoavailability-of-cr-in-silene-vulgaris-the-role-of-soil-plant-genotype-and-bacterial-rhizobiome
#8
P García-Gonzalo, A E Pradas Del Real, M Pirredda, M J Gismera, M C Lobo, A Pérez-Sanz
Understanding the metal behavior at the soil-root interface is of utmost significance for a successful implementation of phytoremediation. In this study, we investigated the differences in chromium (Cr) uptake, chemical changes in soil solution and the shifts in rhizosphere bacterial communities of two genotypes of Silene vulgaris (SV21, SV38) with different tolerance to Cr. A greenhouse experiment was performed in two soils that differed on pH and organic matter (OM) content. An industrial sludge with high content in Cr was used as pollution source...
June 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28645021/development-a-validated-highly-sensitive-lc-ms-ms-method-for-simultaneous-quantification-of-ledipasvir-sofosbuvir-and-its-major-metabolite-gs-331007-in-human-plasma-application-to-a-human-pharmacokinetic-study
#9
Ola M Abdallah, Ahmed M Abdel-Megied, Amira S Gouda
A highly sensitive and rapid LC-MS/MS method was developed, fully optimized and validated for the simultaneous determination of Ledipasvir (LED) and Sofosbuvir (SOF) in the presence of its major metabolite GS-331007 in human plasma using Daclatasvir as internal standard (IS). The extraction of analytes and IS from plasma was performed using liquid-liquid extraction with ethyl acetate. The chromatographic separation of these prepared samples was achieved on Xterra MS C8 column (4.6×50mm,5μm) using gradient elution with a mobile phase of ammonium formate buffer (pH 3...
June 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28645008/effect-of-microrna-129-5p-targeting-hmgb1-rage-signaling-pathway-on-revascularization-in-a-collagenase-induced-intracerebral-hemorrhage-rat-model
#10
Xin-Long Ma, Shu-Ya Li, Feng Shang
BACKGROUND: This study aimed at exploring the effect of microRNA-129-5p (miR-129-5p) targeting high mobility group box-1 (HMGB1)-receptor for advanced glycation end-products (RAGE) signaling pathway on the revascularization in a collagenase-induced intracerebral hemorrhage (ICH) rat model. METHODS: OX26-pGFAP-IL, an immunoliposome expressing miR-129-5p was constructed. The collagenase-induced ICH rat models were successfully established by 96 Sprague Dawley (SD) rats, which were categorized into the sham group, ICH group, miR-129-5p group, negative control (NC) group, ethyl pyruvate (EP, an inhibitor of HMGB1) group and N-benzyl-4-chloro-N-cyclohe-xylbenzamide (FPS-ZM1, a RAGE receptor antagonist) group...
June 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28644924/intravenous-thrombolysis-for-acute-ischemic-stroke-a-bridge-between-two-centuries
#11
Georgios Tsivgoulis, Odysseas Kargiotis, Andrei Alexandrov
Intravenous tissue-plasminogen activator (tPA) remains the only approved systemic reperfusion therapy suitable for most patients presenting timely with acute ischemic stroke. Accumulating real-word experience for over 20 years regarding tPA safety and effectiveness lead to re-appraisal of original contraindications for intravenous thrombolysis (IVT). Areas covered: This narrative review focuses on fast yet appropriate selection of patients for safe administration of tPA per recently expanded indications. Novel strategies for rapid patient assessment will be discussed...
June 23, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28644877/patient-experienced-burden-of-treatment-in-patients-with-multimorbidity-a-systematic-review-of-qualitative-data
#12
Michael Rosbach, John Sahl Andersen
OBJECTIVE: To synthesize existing qualitative literature on patient-experienced burden of treatment in multimorbid patients. METHODS: A literature search identified available qualitative studies on the topic of burden of treatment in multimorbidity and meta-ethnography was applied as method. The authors' original findings were preserved, but also synthesized to new interpretations to investigate the concept of the burden of treatment using the Cumulative Complexity Model...
2017: PloS One
https://www.readbyqxmd.com/read/28644773/mobilized-peripheral-blood-stem-cells-versus-unstimulated-bone-marrow-as-a-graft-source-for-t-cell-replete-haploidentical-donor-transplantation-using-post-transplant-cyclophosphamide
#13
Asad Bashey, Mei-Jie Zhang, Shannon R McCurdy, Andrew St Martin, Trevor Argall, Claudio Anasetti, Stefan O Ciurea, Omotayo Fasan, Sameh Gaballa, Mehdi Hamadani, Pashna Munshi, Monzr M Al Malki, Ryotaro Nakamura, Paul V O'Donnell, Miguel-Angel Perales, Kavita Raj, Rizwan Romee, Scott Rowley, Vanderson Rocha, Rachel B Salit, Melhem Solh, Robert J Soiffer, Ephraim Joseph Fuchs, Mary Eapen
Purpose T-cell-replete HLA-haploidentical donor hematopoietic transplantation using post-transplant cyclophosphamide was originally described using bone marrow (BM). With increasing use of mobilized peripheral blood (PB), we compared transplant outcomes after PB and BM transplants. Patients and Methods A total of 681 patients with hematologic malignancy who underwent transplantation in the United States between 2009 and 2014 received BM (n = 481) or PB (n = 190) grafts. Cox regression models were built to examine differences in transplant outcomes by graft type, adjusting for patient, disease, and transplant characteristics...
June 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28644758/an-independent-shopping-experience-for-wheelchair-users-through-augmented-reality-and-rfid
#14
Zulqarnain Rashid, Rafael Pous, Christopher S Norrie
People with physical and mobility impairments continue to struggle to attain independence in the performance of routine activities and tasks. For example, browsing in a store and interacting with products located beyond an arm's length may be impossible without the enabling intervention of a human assistant. This research article describes a study undertaken to design, develop, and evaluate potential interaction methods for motor-impaired individuals, specifically those who use wheelchairs. Our study includes a user-centered approach, and a categorization of wheelchair users based upon the severity of their disability and their individual needs...
June 23, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28644723/performance-evaluation-of-mobile-downflow-booths-for-reducing-airborne-particles-in-the-workplace
#15
Li-Ming Lo, Braden Hocker, Austin E Steltz, John Kremer, H Amy Feng
Compared to other common control measures, the downflow booth is a costly engineering control used to contain airborne dust or particles. The downflow booth provides unidirectional filtered airflow from the ceiling, entraining released particles away from the workers' breathing zone, and delivers contained airflow to a lower level exhaust for removing particulates by filtering media. In this study, we designed and built a mobile downflow booth that is capable of quick assembly and easy size change to provide greater flexibility and particle control for various manufacturing processes or tasks...
June 23, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28644573/characteristics-of-integrons-and-associated-gene-cassettes-in-antibiotic-resistant-escherichia-coli-isolated-from-free-ranging-food-animals-in-china
#16
Mujeeb Ur Rehman, Hui Zhang, Shucheng Huang, Muhammad Kashif Iqbal, Khalid Mehmood, Houqiang Luo, Jiakui Li
We investigated the occurrence of integrons in antibiotic-resistant Escherichia coli strains isolated from free-ranging food animals, including yaks, piglets, and chickens, in China, and characterized the gene cassettes harbored within the integrons. We examined 432 E. coli strains that exhibited resistance to at least one class of antibiotics. Integrase genes and associated gene cassettes were characterized by polymerase chain reaction (PCR) analysis, restriction fragment-length polymorphism, DNA sequencing, conjugation experiments, and plasmid analysis...
June 23, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28644399/effects-of-biochar-derived-sewage-sludge-on-heavy-metal-adsorption-and-immobilization-in-soils
#17
Dan Zhou, Dan Liu, Fengxiang Gao, Mengke Li, Xianping Luo
The object of this study was to evaluate the effect of sewage sludge biochar on adsorption and mobility of Cr, Mn, Cu, and Zn. Biochar (BC400) was produced via pyrolysis of municipal sewage sludge at 400 °C. Maximum adsorption capacities (qm) for Zn, Cr, Mn, and Cu were 5.905, 5.724, 5.681, and 5.342 mg·g(-1), respectively, in the mono-metal solution and 2.475, 8.204, 1.01, and 5.415 mg·g(-1), respectively, in the multi-metal solution. The adsorption capacities for Mn, Cu, and Zn decreased in the multi-metal solution due to competitive adsorption, whereas the capacity for Cr increased...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28644378/an-energy-efficient-multi-tier-architecture-for-fall-detection-using-smartphones
#18
M Amac Guvensan, A Oguz Kansiz, N Cihan Camgoz, H Irem Turkmen, A Gokhan Yavuz, M Elif Karsligil
Automatic detection of fall events is vital to providing fast medical assistance to the causality, particularly when the injury causes loss of consciousness. Optimization of the energy consumption of mobile applications, especially those which run 24/7 in the background, is essential for longer use of smartphones. In order to improve energy-efficiency without compromising on the fall detection performance, we propose a novel 3-tier architecture that combines simple thresholding methods with machine learning algorithms...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28644375/gaden-a-3d-gas-dispersion-simulator-for-mobile-robot-olfaction-in-realistic-environments
#19
Javier Monroy, Victor Hernandez-Bennets, Han Fan, Achim Lilienthal, Javier Gonzalez-Jimenez
This work presents a simulation framework developed under the widely used Robot Operating System (ROS) to enable the validation of robotics systems and gas sensing algorithms under realistic environments. The framework is rooted in the principles of computational fluid dynamics and filament dispersion theory, modeling wind flow and gas dispersion in 3D real-world scenarios (i.e., accounting for walls, furniture, etc.). Moreover, it integrates the simulation of different environmental sensors, such as metal oxide gas sensors, photo ionization detectors, or anemometers...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28644299/an-inconsolable-loss
#20
Brenda Kelley Burke
A nurse's injury costs her far more than mobility.
July 2017: American Journal of Nursing
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