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Rajeev K Pathak

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https://www.readbyqxmd.com/read/27891315/awareness-about-biomedical-waste-management-and-knowledge-of-effective-recycling-of-dental-materials-among-dental-students
#1
Rajeev Ranjan, Ruchi Pathak, Dhirendra K Singh, Md Jalaluddin, Shobha A Kore, Abhijeet R Kore
AIMS AND OBJECTIVES: Biomedical waste management has become a concern with increasing number of dental practitioners in India. Being health care professionals, dentists should be aware regarding safe disposal of biomedical waste and recycling of dental materials to minimize biohazards to the environment. The aim of the present study was to assess awareness regarding biomedical waste management as well as knowledge of effective recycling and reuse of dental materials among dental students...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27890738/ventricular-arrhythmias-associated-with-left-ventricular-non-compaction-electrophysiological-characteristics-mapping-and-ablation
#2
Daniele Muser, Jackson J Liang, Walter R T Witschey, Rajeev K Pathak, Simon Castro, Silvia Magnani, Erica S Zado, Fermin C Garcia, Benoit Desjardins, David J Callans, David S Frankel, Francis E Marchlinski, Pasquale Santangeli
BACKGROUND: Left ventricular non-compaction (LVNC) is a primary cardiomyopathy that can present with recurrent ventricular arrhythmias (VAs). Data on the benefit of catheter ablation (CA) of VAs in LVNC are lacking. OBJECTIVES: To describe the electrophysiologic features and outcomes of CA of VAs in LVNC. METHODS: The cohort consisted of 9 patients (age 42±15 years) with diagnosis of LVNC based upon established criteria and VA (VT in 3 and frequent PVCs in 6) despite treatment with a mean of 2±1 antiarrhythmic drugs (AADs)...
November 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27784738/pulmonary-vein-antral-isolation-and-nonpulmonary-vein-trigger-ablation-are-sufficient-to-achieve-favorable-long-term-outcomes-including-transformation-to-paroxysmal-arrhythmias-in-patients-with-persistent-and-long-standing-persistent-atrial-fibrillation
#3
Jackson J Liang, Melissa A Elafros, Daniele Muser, Rajeev K Pathak, Pasquale Santangeli, Erica S Zado, David S Frankel, Gregory E Supple, Robert D Schaller, Rajat Deo, Fermin C Garcia, David Lin, Mathew D Hutchinson, Michael P Riley, David J Callans, Francis E Marchlinski, Sanjay Dixit
BACKGROUND: Transformation from persistent to paroxysmal atrial fibrillation (AF) after ablation suggests modification of the underlying substrate. We examined the nature of initial arrhythmia recurrence in patients with nonparoxysmal AF undergoing antral pulmonary vein isolation and nonpulmonary vein trigger ablation and correlated recurrence type with long-term ablation efficacy after the last procedure. METHODS AND RESULTS: Three hundred and seventeen consecutive patients with persistent (n=200) and long-standing persistent (n=117) AF undergoing first ablation were included...
November 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27733494/long-term-outcome-after-catheter-ablation-of-ventricular-tachycardia-in-patients-with-nonischemic-dilated-cardiomyopathy
#4
Daniele Muser, Pasquale Santangeli, Simon A Castro, Rajeev K Pathak, Jackson J Liang, Tatsuya Hayashi, Silvia Magnani, Fermin C Garcia, Mathew D Hutchinson, Gregory G Supple, David S Frankel, Michael P Riley, David Lin, Robert D Schaller, Sanjay Dixit, Erica S Zado, David J Callans, Francis E Marchlinski
BACKGROUND: Catheter ablation (CA) of ventricular tachycardia (VT) in patients with nonischemic dilated cardiomyopathy can be challenging because of the complexity of underlying substrates. We sought to determine the long-term outcomes of endocardial and adjuvant epicardial CA in nonischemic dilated cardiomyopathy. METHODS AND RESULTS: We examined 282 consecutive patients (aged 59±15 years, 80% males) with nonischemic dilated cardiomyopathy who underwent CA. Ablation was guided by activation/entrainment mapping for tolerated VT and pacemapping/targeting of abnormal electrograms for unmappable VT...
October 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27569577/distinct-electrocardiographic-form-of-idiopathic-ventricular-arrhythmia-originating-from-the-left-bundle-branch
#5
Rajeev K Pathak, Brian P Betensky, Pasquale Santangeli, Sanjay Dixit
Most premature ventricular contractions (PVCs) arise from the right or left ventricular outflow tract. Some VPCs originate near the His-bundle region. However, there remains a paucity of information on PVCs originating directly from the cardiac conduction system. We describe two cases with idiopathic frequent PVCs that were mapped directly to the left bundle branch itself. We also provide an anatomic-based mapping and ablation approach for management of these uncommon and challenging arrhythmias. In both cases we were able to either eliminate or significantly suppress the ectopic source by applying radiofrequency at this location without causing any significant impairment of the atrioventricular conduction...
August 28, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27544100/encaged-molecules-in-external-electric-fields-a-molecular-tug-of-war
#6
Nalini D Gurav, Shridhar P Gejji, Libero J Bartolotti, Rajeev K Pathak
Response of polar molecules CH3OH and H2O2 and a non-polar molecule, CO2, as "guests" encapsulated in the dodecahedral water cage (H2O)20 "host," to an external, perturbative electric field is investigated theoretically. We employ the hybrid density-functionals M06-2X and ωB97X-D incorporating the effects of damped dispersion, in conjunction with the maug-cc-pVTZ basis set, amenable for a hydrogen bonding description. While the host cluster (cage) tends to confine the embedded guest molecule through cooperative hydrogen bonding, the applied electric field tends to rupture the cluster-composite by stretching it; these two competitive effects leading to a molecular "tug-of-war...
August 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27516457/long-term-outcomes-of-catheter-ablation-of-ventricular-tachycardia-in-patients-with-cardiac-sarcoidosis
#7
Daniele Muser, Pasquale Santangeli, Rajeev K Pathak, Simon A Castro, Jackson J Liang, Silvia Magnani, Tatsuya Hayashi, Fermin C Garcia, Mathew D Hutchinson, Gregory E Supple, David S Frankel, Michael P Riley, David Lin, Robert D Schaller, Benoit Desjardins, Sanjay Dixit, David J Callans, Erica S Zado, Francis E Marchlinski
BACKGROUND: Catheter ablation (CA) of ventricular tachycardia (VT) in patients with cardiac sarcoidosis can be challenging because of the complex underlying substrate. We sought to determine the long-term outcome of CA of VT in patients with cardiac sarcoidosis. METHODS AND RESULTS: We enrolled 31 patients (age, 55±10 years) with diagnosis of cardiac sarcoidosis based on Heart Rhythm Society criteria and VT who underwent CA. In 23 (74%) patients, preprocedure cardiac magnetic resonance imaging and positron emission tomographic (PET) evaluation were performed...
August 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27112903/lifestyle-management-to-prevent-and-treat-atrial-fibrillation
#8
Celine Gallagher, Jeroen M L Hendriks, Rajiv Mahajan, Melissa E Middeldorp, Adrian D Elliott, Rajeev K Pathak, Prashanthan Sanders, Dennis H Lau
INTRODUCTION: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with a one in four lifetime risk in adults over the age of forty. Traditionally, AF management has focused on the three pillars of rate control, rhythm control and appropriate anticoagulation to reduce stroke risk. More recently, the importance of cardiovascular risk factor management in AF has emerged as a fourth and essential pillar with improved patient outcomes. AREAS COVERED: Here, we aim to summarize the current available evidence for the association between various modifiable risk factors and AF, and to identify optimal treatment targets to improve outcomes...
July 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27066518/can-intensified-tuberculosis-case-finding-efforts-at-nutrition-rehabilitation-centers-lead-to-pediatric-case-detection-in-bihar-india
#9
Rajeev R Pathak, Bal Krishna Mishra, Patrick K Moonan, Sreenivas A Nair, Ajay M V Kumar, Mohit P Gandhi, Shamim Mannan, Smita Ghosh
INTRODUCTION: Seven district-level Nutritional Rehabilitation Centres (NRCs) in Bihar, India provide clinical and nutritional care for children with severe acute malnutrition (SAM). AIM: To assess whether intensified case finding (ICF) strategies at NRCs can lead to pediatric case detection among SAM children and link them to TB treatment under the Revised National Tuberculosis Control Programme (RNTCP). MATERIALS AND METHODS: A retrospective cohort study was conducted that included medical record reviews of SAM children registered for TB screening and RNTCP care during July-December 2012...
March 30, 2016: Journal of Tuberculosis Research
https://www.readbyqxmd.com/read/26733608/exercise-training-and-atrial-fibrillation-further-evidence-for-the-importance-of-lifestyle-change
#10
EDITORIAL
Adrian D Elliott, Rajiv Mahajan, Rajeev K Pathak, Dennis H Lau, Prashanthan Sanders
No abstract text is available yet for this article.
February 2, 2016: Circulation
https://www.readbyqxmd.com/read/26113406/impact-of-cardiorespiratory-fitness-on-arrhythmia-recurrence-in-obese-individuals-with-atrial-fibrillation-the-cardio-fit-study
#11
COMPARATIVE STUDY
Rajeev K Pathak, Adrian Elliott, Melissa E Middeldorp, Megan Meredith, Abhinav B Mehta, Rajiv Mahajan, Jeroen M L Hendriks, Darragh Twomey, Jonathan M Kalman, Walter P Abhayaratna, Dennis H Lau, Prashanthan Sanders
BACKGROUND: Obesity begets atrial fibrillation (AF). Although cardiorespiratory fitness is protective against incident AF in obese individuals, its effect on AF recurrence or the benefit of cardiorespiratory fitness gain is unknown. OBJECTIVES: This study sought to evaluate the role of cardiorespiratory fitness and the incremental benefit of cardiorespiratory fitness improvement on rhythm control in obese individuals with AF. METHODS: Of 1,415 consecutive patients with AF, 825 had a body mass index ≥27 kg/m(2) and were offered risk factor management and participation in a tailored exercise program...
September 1, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26085295/sleep-apnea-and-cardiac-arrhythmia-a-timely-wake-up-call
#12
EDITORIAL
Rajeev K Pathak, Rajiv Mahajan, Dennis H Lau, Prashanthan Sanders
No abstract text is available yet for this article.
2015: Sleep
https://www.readbyqxmd.com/read/26049498/ch3oh%C3%A2-h2o-n-n-1-4-clusters-in-external-electric-fields
#13
Nalini D Gurav, Anant D Kulkarni, Shridhar P Gejji, Rajeev K Pathak
For hydrogen-bonded neutral molecular clusters, response to an externally applied electric field can critically affect molecular cooperativity. In this light, response of dilute methanol-water admixtures to an external, perturbative electric field is studied at the simplest molecular level in the cluster configurations CH3OH⋯(H2O)n with "n" chosen to range from 1 to 4, employing the M06-2X hybrid functional in conjunction with the 6-311++G(2d,2p) basis set, well-suited for hydrogen bonding. Methanol is seen to favorably bond with the water molecules at its hydroxyl end up to certain characteristic maximum threshold field strengths beyond which the HOMO-LUMO energy-gap abruptly drops to zero culminating into a complete breakdown of the cluster...
June 7, 2015: Journal of Chemical Physics
https://www.readbyqxmd.com/read/25983009/remote-monitoring-of-implantable-cardioverter-defibrillators-a-systematic-review-and-meta-analysis-of-clinical-outcomes
#14
REVIEW
Nirmalatiban Parthiban, Adrian Esterman, Rajiv Mahajan, Darragh J Twomey, Rajeev K Pathak, Dennis H Lau, Kurt C Roberts-Thomson, Glenn D Young, Prashanthan Sanders, Anand N Ganesan
BACKGROUND: Remote monitoring (RM) of implantable cardioverter-defibrillators (ICD) is an established technology integrated into clinical practice. One recent randomized controlled trial (RCT) and several large device database studies have demonstrated a powerful survival advantage for ICD patients undergoing RM compared with those receiving conventional in-office (IO) follow-up. OBJECTIVES: This study sought to conduct a systematic published data review and meta-analysis of RCTs comparing RM with IO follow-up...
June 23, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25965590/underuse-and-overuse-of-anticoagulation-for-atrial-fibrillation-a-study-in-indigenous-and-non-indigenous-australians
#15
Christopher X Wong, Sarah W Lee, Siang Wei Gan, Rajiv Mahajan, Geetanjali Rangnekar, Rajeev K Pathak, Darragh Twomey, Carlee Schultz, Anand N Ganesan, Anthony G Brooks, Kurt C Roberts-Thomson, Alex Brown, Dennis H Lau, Prashanthan Sanders
BACKGROUND: Atrial fibrillation (AF) is a leading cause of preventable stroke in Australia. Given that anticoagulation therapy can significantly reduce this stroke risk, we sought to characterise anticoagulation use in Indigenous and non-Indigenous Australians with AF. METHODS: Administrative, clinical and prescription data from patients with AF were linked. Anticoagulation use was characterised according to guideline-recommended risk scores and Indigenous status...
July 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25792361/long-term-effect-of-goal-directed-weight-management-in-an-atrial-fibrillation-cohort-a-long-term-follow-up-study-legacy
#16
Rajeev K Pathak, Melissa E Middeldorp, Megan Meredith, Abhinav B Mehta, Rajiv Mahajan, Christopher X Wong, Darragh Twomey, Adrian D Elliott, Jonathan M Kalman, Walter P Abhayaratna, Dennis H Lau, Prashanthan Sanders
BACKGROUND: Obesity and atrial fibrillation (AF) frequently coexist. Weight loss reduces the burden of AF, but whether this is sustained, has a dose effect, or is influenced by weight fluctuation is unknown. OBJECTIVES: This study sought to evaluate the long-term impact of weight loss and weight fluctuation on rhythm control in obese individuals with AF. METHODS: Of 1,415 consecutive patients with AF, 825 had a body mass index ≥ 27 kg/m(2) and were offered weight management...
May 26, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25661555/the-implications-of-obesity-for-cardiac-arrhythmia-mechanisms-and-management
#17
REVIEW
Rajeev K Pathak, Rajiv Mahajan, Dennis H Lau, Prashanthan Sanders
The ever-increasing prevalence of obesity poses a significant burden on the health care system with escalating socioeconomic consequences. At the individual level, obesity is well recognized to increase morbidity and mortality. Not only is obesity an established cardiovascular risk factor, it also increases the risk of sudden cardiac death and atrial fibrillation. Studies have shown that increased adiposity itself and the accompanying metabolic consequences of weight gain contribute to an abnormal arrhythmogenic substrate...
February 2015: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/25456757/aggressive-risk-factor-reduction-study-for-atrial-fibrillation-and-implications-for-the-outcome-of-ablation-the-arrest-af-cohort-study
#18
Rajeev K Pathak, Melissa E Middeldorp, Dennis H Lau, Abhinav B Mehta, Rajiv Mahajan, Darragh Twomey, Muayad Alasady, Lorraine Hanley, Nicholas A Antic, R Doug McEvoy, Jonathan M Kalman, Walter P Abhayaratna, Prashanthan Sanders
BACKGROUND: The long-term outcome of atrial fibrillation (AF) ablation demonstrates attrition. This outcome may be due to failure to attenuate the progressive substrate promoted by cardiovascular risk factors. OBJECTIVES: The goal of this study was to evaluate the impact of risk factor and weight management on AF ablation outcomes. METHODS: Of 281 consecutive patients undergoing AF ablation, 149 with a body mass index ≥27 kg/m(2) and ≥1 cardiac risk factor were offered risk factor management (RFM) according to American Heart Association/American College of Cardiology guidelines...
December 2, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25456506/catheter-ablation-of-atrial-fibrillation-in-patients-with-concomitant-left-ventricular-impairment-a-systematic-review-of-efficacy-and-effect-on-ejection-fraction
#19
REVIEW
Anand N Ganesan, Savvy Nandal, Jakob Lüker, Rajeev K Pathak, Rajiv Mahajan, Darragh Twomey, Dennis H Lau, Prashanthan Sanders
INTRODUCTION: Catheter ablation of atrial fibrillation (AF) is an established rhythm control strategy; however, the impact of co-existing LV systolic dysfunction (LVSD) on ablation success is less well understood. This systematic review compiles the outcomes of catheter ablation of atrial fibrillation in patients with LVSD. METHODS: An electronic database (Pubmed, Scopus, Embase) search using the keywords 'atrial fibrillation AND ablation AND (ventricular dysfunction OR heart failure OR cardiomyopathy)' was performed for English scientific literature up to 01/01/2014...
March 2015: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/24047162/complete-sequence-and-characterization-of-mitochondrial-genome-in-great-snakehead-channa-marulius-hamilton-1822
#20
Rajeev K Singh, Vindhya Mohindra, Abhinav Pathak, Kuldeep K Lal, J K Jena
The complete nucleotide sequence of mitogenome of the great snakehead, Channa marulius (Channidae), was determined and found to be 16,569 base pairs in length. The content and arrangement of different genes on the mitogenome was found similar to other typical teleosts. The overall base composition of the L-strand was found to be T (19.1%), C (31.5%), A (34.8%) and G (14.6%). The control region was 915 nt long and without any repetitive region. The mitogenome sequence data would be useful for studying phylogenetic relationship of C...
June 2015: Mitochondrial DNA
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