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https://www.readbyqxmd.com/read/27933698/sofosbuvir-plus-ribavirin-in-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-c-virus-genotype-1-or-3-infection-in-india
#1
S R Shah, A Chowdhury, R Mehta, D Kapoor, A Duseja, A Koshy, A Shukla, A Sood, K Madan, R Sud, S Nijhawan, R Pawan, M Prasad, K Kersey, D Jiang, E Svarovskaia, B Doehle, B Kanwar, M Subramanian, S K Acharya, S Sarin
Until 2014, pegylated interferon plus ribavirin was the recommended standard of care for the treatment of chronic hepatitis C virus (HCV) infection in India. This open-label phase 3b study, conducted across 14 sites in India between 31 March 2014 and 30 November 2015, evaluated the efficacy and safety of sofosbuvir plus ribavirin therapy among treatment-naïve patients with chronic genotype 1 or 3 HCV infection. A total of 117 patients with genotype 1 or 3 HCV infection were randomized 1:1 to receive sofosbuvir 400 mg and weight-based ribavirin (1000 or 1200 mg) daily for 16 or 24 weeks...
December 9, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27933447/indian-summer-heat-wave-of-2015-a-biometeorological-analysis-using-half-hourly-automatic-weather-station-data-with-special-reference-to-andhra-pradesh
#2
M A Sarath Chandran, A V M Subba Rao, V M Sandeep, V P Pramod, P Pani, V U M Rao, V Visha Kumari, Ch Srinivasa Rao
Heat wave is a hazardous weather-related extreme event that affects living beings. The 2015 summer heat wave affected many regions in India and caused the death of 2248 people across the country. An attempt has been made to quantify the intensity and duration of heat wave that resulted in high mortality across the country. Half hourly Physiologically Equivalent Temperature (PET), based on a complete heat budget of human body, was estimated using automatic weather station (AWS) data of four locations in Andhra Pradesh state, where the maximum number of deaths was reported...
December 8, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27933236/purification-and-antigenic-detection-of-o-specific-polysaccharides-of-salmonella-enterica-serovar-paratyphi-a-isolate-from-pakistan-an-emerging-threat
#3
Zainab Rahmat, Aamir Ali, Yasra Sarwar, Muhammad Salman, Abdul Haque
BACKGROUND: Paratyphoid fever caused by Salmonella enterica serovar Paratyphi A is becoming a serious health problem in Asian countries particularly Pakistan, China and India and situation is aggravated by current unavailability of a licensed vaccine. This study was designed to purify the O-specific polysaccharides (OSP) produced by an isolate of Salmonella Paratyphi A from Pakistan and detect antigenicity of extracted lipopolysaccharide (LPS) and purified OSP pioneerly in South Asian region as candidate for conjugate vaccine preparation...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933195/cr1-exon-variants-are-associated-with-lowered-cr1-expression-and-increased-susceptibility-to-sle-in-a-plasmodium-falciparum-endemic-population
#4
Aditya K Panda, Balachandran Ravindran, Bidyut K Das
BACKGROUND: Complement receptor 1 (CR1) plays an important role in immune complex clearance by opsonisation and possibly protects subjects from development of autoantibodies. Lower CR1 expression has been associated with susceptibility to systemic lupus erythematosus (SLE). In contrast, subjects displaying lower CR1 expression are protected against severe manifestations of falciparum malaria. This study is the first of its kind to investigate the association of CR1 variants with development of SLE in a P...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27932923/india-biodiversity-portal-an-integrated-interactive-and-participatory-biodiversity-informatics-platform
#5
Thomas Vattakaven, Rohit M George, Dhandapani Balasubramanian, Maxime Réjou-Méchain, Gowrappan Muthusankar, Brahmasamudra Ranganna Ramesh, R Prabhakar
BACKGROUND: This paper describes a growing biodiversity platform, launched in 2008, which organizes knowledge on the biodiversity of India. The main objective and originality of the India Biodiversity Portal (IBP) is to aggregate curated biodiversity data of different kinds (e.g. distribution maps, temporal distribution or life history) in an integrated platform where amateurs and experts can easily interact. NEW INFORMATION: Since its launch, the platform has seen an exceptional increase in both user activity and biodiversity data...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932640/complete-genome-sequence-of-a-genotype-iii-japanese-encephalitis-virus-isolated-from-pigs-in-sichuan-china
#6
Yuancheng Zhou, Xiuping Zhuo, Jianqiang Ye, Yuhan Cai
A complete genomic sequence of Japanese encephalitis virus (JEV) was detected by viral metagenome analysis on aborted piglets. A phylogenetic analysis of this genome reveals that it is highly similar to previously reported India JEV genomes. The complete JEV sequence is 10,718 nucleotides long.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27932638/draft-genome-sequences-of-three-hypervirulent-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-bacteremia
#7
Chaitra Shankar, Laura E B Nabarro, Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Jones Lionel Kumar Daniel, George Priya Doss C, Balaji Veeraraghavan
Hypervirulent Klebsiella pneumoniae strains have been increasingly reported worldwide, and there is emergence of carbapenem resistance among them. Here, we report the genome sequences of three carbapenem-resistant hypervirulent K. pneumoniae isolates isolated from bacteremic patients at a tertiary-care center in South India.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27932291/influenza-not-mers-cov-among-returning-hajj-and-umrah-pilgrims-with-respiratory-illness-kashmir-north-india-2014-15
#8
Parvaiz A Koul, Hyder Mir, Siddhartha Saha, Mandeep S Chadha, Varsha Potdar, Marc-Alain Widdowson, Renu B Lal, Anand Krishnan
BACKGROUND: The increasing reports of Middle East Respiratory Syndrome (MERS) caused by MERS coronavirus (MERS-CoV) from many countries emphasize its importance for international travel. Muslim pilgrimages of Hajj and Umrah involve mass gatherings of international travellers. We set out to assess the presence of influenza and MERS-CoV in Hajj/Umrah returnees with acute respiratory infection. . METHODS: Disembarking passengers (n = 8753) from Saudi Arabia (October 2014 to April 2015) were interviewed for the presence of respiratory symptoms; 977 (11%) reported symptoms and 300 (age 26-90, median 60 years; 140 male) consented to participate in the study...
December 5, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27932013/socio-economic-inequalities-in-health-and-health-service-use-among-older-adults-in-india-results-from-the-who-study-on-global-ageing-and-adult-health-survey
#9
E M Brinda, J Attermann, U G Gerdtham, U Enemark
OBJECTIVE: The objectives of this study were to measure socio-economic inequalities in self-reported health (SRH) and healthcare visits and to identify factors contributing to health inequalities among older people aged 50-plus years. STUDY DESIGN: This study is based on a population-based, cross-sectional survey. METHODS: We accessed data of 7150 older adults from the World Health Organization's Study on Global AGEing and adult health Indian survey...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931918/sexual-dysfunction-among-women-with-schizophrenia-a-cross-sectional-study-from-india
#10
Manjula Simiyon, Prabha S Chandra, Geetha Desai
: Sexual dysfunction among women usually has a multifactorial etiology and is also difficult to study in cultures where open discussions about sexuality are not common. Not much is known about sexual function in women with schizophrenia even though it may have a significant impact on their quality of life and maybe influenced by several factors. AIMS AND OBJECTIVES: This study aimed to assess the frequency and nature of sexual dysfunction in women with schizophrenia and study its association with marital quality, illness, treatment, and socio-demographic factors...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931915/stratifying-empiric-risk-of-schizophrenia-among-first-degree-relatives-using-multiple-predictors-in-two-independent-indian-samples
#11
Triptish Bhatia, Elizabeth A Gettig, Irving I Gottesman, Jonathan Berliner, N N Mishra, Vishwajit L Nimgaonkar, Smita N Deshpande
BACKGROUND: Schizophrenia (SZ) has an estimated heritability of 64-88%, with the higher values based on twin studies. Conventionally, family history of psychosis is the best individual-level predictor of risk, but reliable risk estimates are unavailable for Indian populations. Genetic, environmental, and epigenetic factors are equally important and should be considered when predicting risk in 'at risk' individuals. OBJECTIVE: To estimate risk based on an Indian schizophrenia participant's family history combined with selected demographic factors...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931898/cross-cultural-differences-on-gunas-and-other-well-being-dimensions
#12
Kamlesh Singh, Anjali Jain, Jasleen Kaur, Mohita Junnarkar, Alena Slezackova
Indian perspective of human nature and personality are often viewed through a trigunas perspective-Sattva, Rajas and Tamas. The current study investigated the triadic gunas and well-being dimensions across 3 nations India (n=493; 194 males and 299 females; mean age=21.73 years, SD=3.23), USA (n=302; 80 males and 222 females; mean age=22.90years, SD=2.78) and Czech Republic (n=353; 67 males and 286 females; mean age=22.29years, SD=2.29) with a total of 1148 participants. Triguna Personality (Vedic Personality inventory) and well- being dimensions measured by Mental Health Continuum- Short Form, Flourishing scale and the Scale of Positive and Negative Experiences (MHC-SF, FS and SPANE) differed across countries...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931897/is-suicide-reporting-in-indian-newspapers-responsible-a-study-from-rajasthan
#13
Nikhil Jain, Sunil Kumar
PURPOSE: Media reporting has consistently been shown to influence suicidal behaviour. Irresponsible reporting by the media can lead to imitative suicidal behaviour. The WHO has delineated guidelines for responsible media reporting of suicide. The study aims to examine whether Indian newspapers adhere to the WHO guidelines and whether there are differences in style of reporting between local and national newspapers and between English and Hindi newspapers. METHODS: The study was conducted on ten newspaper publications that were circulated in Jaipur, India from 1st October 2014 to 31st December 2014...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931679/extrapulmonary-tuberculosis-among-females-in-south-asia-gap-analysis
#14
Jaishri Mehraj, Zain Yar Khan, Dania Khalid Saeed, Sadia Shakoor, Rumina Hasan
The percentage of extrapulmonary tuberculosis (EPTB) among new and relapse tuberculosis cases in South Asia (Afghanistan, Pakistan, India, and Bangladesh) ranged from 19% to 23% in 2014. While tuberculosis was reportedly more prevalent in males, a higher preponderance of EPTB was observed in females. National tuberculosis control programs are highly focused on pulmonary tuberculosis. This creates gaps in the surveillance, diagnosis, and study of EPTB among females, which is especially pronounced in the South Asian setting...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931562/management-protocols-of-stable-coronary-artery-disease-in-india-executive-summary
#15
Sundeep Mishra, Saumitra Ray, Jamshed J Dalal, J P S Sawhney, S Ramakrishnan, Tiny Nair, S S Iyengar, Vinay K Bahl
No abstract text is available yet for this article.
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931560/a-kerala-model-for-cardiovascular-research
#16
REVIEW
Geevar Zachariah, Mohanan Padinharepurayil, Krishnan Mangalath Narayanan
India's contribution to cardiovascular research has been dismal with a share of only 1% of total number of papers published in the world during the period 1999-2008. Based on two recent studies published from Kerala, the Kerala ACS Registry and the CSI Kerala CRP Study and four other studies being undertaken in Kerala, we think that a Kerala model for cardiovascular research can be conceptualized. This model which consists of funding by professional organization of cardiologists with wide participation of cardiologists, physicians, health workers, nurses, and in some situations general public, logistics looked after by a central coordinator and study design by panel of experts or institutions of repute in the region and carried out at low cost can be considered for implementation in rest of India...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931554/a-study-to-derive-distribution-of-carotid-intima-media-thickness-and-to-determine-its-correlation-with-cardiovascular-risk-factors-in-asymptomatic-nationwide-indian-population-score-india
#17
Ravi R Kasliwal, Manish Bansal, Nagaraj Desai, Bhavesh Kotak, Ammar Raza, Hardik Vasnawala, Amit Kumar
BACKGROUND: There is presently no data to describe normal distribution of carotid intima-media thickness (CIMT), an established measure of subclinical atherosclerosis, in Indian subjects. METHODS: In this multi-centric study, 1229 subjects with age ≥30 years and no previous cardiovascular disease (CVD) underwent CVD risk factor assessment and CIMT measurement. Mean far wall common carotid artery IMT was measured on both sides and averaged. RESULTS: Mean age of the subjects was 48...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931546/maternal-and-fetal-outcomes-in-pregnant-women-undergoing-balloon-mitral-valvotomy-for-rheumatic-mitral-stenosis
#18
Desabandhu Vinayakumar, G V Vinod, Suresh Madhavan, Mangalath Narayanan Krishnan
BACKGROUND: Rheumatic mitral stenosis constitutes a major cause of acquired heart disease complicating pregnancy in India. In the present study, we have studied the fetal and maternal outcomes of women undergoing balloon mitral valvotomy during pregnancy. METHODS AND RESULTS: 49 pregnant ladies were included in this study in whom balloon mitral valvotomy was performed. The mean age of these patients was 25.7±3.1 years. The mean gestational age was 23.5±5.2 weeks (12-36 weeks)...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931540/intensive-statin-therapy-in-india-demonstrating-efficacy-and-safety
#19
EDITORIAL
Michael H Davidson
No abstract text is available yet for this article.
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931345/factors-associated-with-sputum-culture-conversion-in-multidrug-resistant-pulmonary-tuberculosis
#20
B Velayutham, D Nair, T Kannan, C Padmapriyadarsini, K S Sachdeva, J Bency, J S Klinton, S Haldar, A Khanna, S Jayasankar, S Swaminathan
INTRODUCTION: Sputum culture conversion in pulmonary multidrug-resistant tuberculosis (MDR-TB) is important to make treatment-related decisions and prevent transmission of disease. OBJECTIVE: To identify factors associated with sputum culture conversion, and to determine time to culture conversion and the impact of culture conversion on successful treatment outcomes in MDR-/rifampicin (RMP) resistant TB. METHOD: Retrospective analysis of data from treatment cards and registers of MDR-/RMP-resistant patients initiated on treatment under India's Revised National TB Control Programme in Delhi, West Bengal and Kerala from January 2009 to December 2011...
December 2016: International Journal of Tuberculosis and Lung Disease
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