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Murat Kutlay, Abdullah Durmaz, İlker Özer, Cahit Kural, Çağlar Temiz, Serdar Kaya, İlker Solmaz, Mehmet Daneyemez, Yusuf Izci
OBJECTIVE: With the use of multiple endoscopic endonasal surgical corridors, extended endoscopic endonasal approaches (EEEAs) are now being used to treat a wide range of ventral skull base lesions. Our aim was to present our experience with EEEAs to the ventral skull base lesions. PATIENTS AND METHODS: The study group consisted of 106 patients (57 men and 49 women) who underwent surgery for skull base lesions using EEEAs from 2010 to 2017. The EEEA was most commonly used for giant pituitary macroadenomas, sinonasal malignancies, cerebrospinal fluid (CSF) leaks, meningiomas, craniopharyngiomas, and fibro-osseous lesions...
April 2018: Clinical Neurology and Neurosurgery
Nathalie Coulon, Sylvie Brailly-Tabard, Michel Walter, Sylvie Tordjman
This article focuses on stress vulnerability in schizophrenia through an integrated clinical and biological approach. The objective of this article is to better understand the relationships between vulnerability, stress and schizophrenia. First, the concept of vulnerability is defined and several models of vulnerability in schizophrenia are reviewed. Second, a section is developed on the biology of stress, and more specifically on the stress responses of the hypothalamo-pitutary adrenal (HPA) axis. Then, studies of cortisol circadian rhythms are summarized, suggesting hyper-reactivity of the HPA axis in patients with schizophrenia and high risk individuals for schizophrenia...
November 2016: Journal of Physiology, Paris
Di Wang, Cheng-Yu Lu, Le-Sheng Teng, Zhi-Hua Guo, Qing-Fan Meng, Yan Liu, Linda Ld Zhong, Wei Wang, Jing Xie, Zhang-Jin Zhang
This is a systemic review of plants used traditionally for neuroendocrinological diseases related to hypothalamus-pitutary-adrenal (HPA) and hypothalamus-pitutary-gland (HPG) axis. By searching from PubMed literature search system (1950-2013), Medline (1950-2013) and CNKI (China Journals of Full-text database; 1989-2013), 105 papers met the inclusion criteria were displayed in this review. 96 herbal drugs were classified into two parts which include hormones mainly related to HPA and HPG axis. The full scientific name of each herbal medicine, dose ranges and routes, models or diseases, affect on hormones and pertinent references are presented via synoptic tables...
May 2014: Pakistan Journal of Pharmaceutical Sciences
Rupal V Dosi, Rushad D Patell, Pratik J Shah, Harshal K Joshi
Secondary diabetes mellitus is known to occur in acromegaly due to insulin resistance caused by growth hormone excess. However, diabetes in acromegaly usually does not lead to ketosis. We describe an unusual case of a patient that presented with diabetic ketoacidosis in the emergency room with thirst, polyuria and dyspnoea. The patient was subsequently diagnosed with a growth hormone-secreting pitutary macroadenoma as the underlying pathology; after initial stabilisation with insulin and fluids, the patient was successfully treated with trans-sphenoidal surgery...
2013: BMJ Case Reports
S Narayana
The role of triodothyronine (T(3) in regulating thyroid function is paramount in that at cellular level it interacts with receptors in the nucleus and thereby modulates gene expression. The multiple steps in the processing of lodide by the thyroid gland is under the influence of the thyroid stimulating hormone (TSH). In terms of laboratory evaluation of thyroid function the primary test is TSH. To discriminate between hypothalamic and pitutary dysfunction, the thyroid releasing hormone (TRH) stimulation test is useful...
December 1997: Indian Journal of Clinical Biochemistry: IJCB
Anne E Chambers, Paul F Stanley, Harpal Randeva, Subhasis Banerjee
Placental hCG and pitutary LH transduce signals in target tissues through a common receptor (LHCGR). We demonstrate that recombinant LHCGR proteins which include the hormone-binding domain are secreted from transfected cells and that natural LHCGR is also secreted from human placental explants. LHCGR recombinant proteins representing varying lengths of the N-terminal extracellular domain were expressed in Chinese Hamster Ovary cells in suspension culture. Secretion was minimal up to 72h but by 96h 24-37% of the LHCGR had been released into the culture medium...
2011: Reproductive Biology and Endocrinology: RB&E
Can Yan, Zhi-wei Xu
Methods and thoughts of the further research on central neurobiological mechanisms of Gan in taking charge of dispersion and regulating emotion are discussed. By applying the holistic approach and homeostasis theory, combined with modern psychological stress theory, the authors put forward their hypothesis of study. They offered that the TCM theory of "Gan takes charge of dispersion and could regulate emotion" is affirmatively to have certain mechanisms of central neurobiology. So, cut-in from the point of psychological stress reaction, adopting the research thoughts of "prescription-syndrome-therapeutic effectiveness--essence of Zang-Fu function", a model of chronic psychological stress reaction (CPSR) for imitating the process of comprehensive pathologic change due to Gan fails to take charge of dispersion and leads to emotional disorder was established...
May 2005: Chinese Journal of Integrated Traditional and Western Medicine
Filip Gołkowski, Małgorzata Trofimiuk, Monika Buziak-Bereza, Ryszard Czepko, Dariusz Adamek, Bohdan Huszno
UNLABELLED: New imaging modalities and hormonal diagnostic improvement have markedly increased the number of newly recognized pituitary tumours. Introduction of immunohistochemical assays in histopathological diagnostics of pitutary adenomas resulted in better understanding of pathology and clinics of these neoplasms. The aim of the study was to correlate the hormonal status and hematoxylin-eosin staining results with immunohistochemical staining of pituitary tumours. The study included 40 patients aged 43...
2003: Przegla̧d Lekarski
No abstract text is available yet for this article.
December 1962: Journal of Endocrinology
No abstract text is available yet for this article.
August 1962: Journal of Neurosurgery
No abstract text is available yet for this article.
1960: Acta Medica Academiae Scientiarum Hungaricae
J Kurian, V Kaul
PURPOSE: To present an unusual case of profound postoperative hypoglycemia resulting in irreversible brain damage in a malnourished patient. CLINICAL FEATURES: A 56-yr-old malnourished woman underwent laparotomy for intestinal obstruction under general anesthesia. Five hours postoperatively she was found to be unresponsive with an immeasureably low blood glucose level. This event was not associated with hyperinsulinemia. Predisposing factors like diabetes mellitus, pheochromocytoma, insulin secreting tumours, adrenal or pitutary deficiency were absent...
October 2001: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
B Marchetti, F Gallo, Z Farinella, C Tirolo, N Testa, S Caniglia, M C Morale
Signals generated by the hypothalamic-pitutary-gonadal (HPG) axis powerfully modulate immune system function. This article summarizes some aspects of the impact of gender in neuroendocrine immunomodulation. Emphasis is given to the astroglial cell compartment, defined as a key actor in neuroendocrine immune communications. In the brain, the principal hormones of the HPG axis directly interact with astroglial cells. Thus, luteinizing hormone releasing hormone, LHRH, influences hypothalamic astrocyte development and growth, and hypothalamic astrocytes direct LHRH neuron differentiation...
2000: Annals of the New York Academy of Sciences
N E Love, P Fisher, L Hudson
Dynamic computed tomography (CT) of the pituitary gland was performed on four healthy male dogs of similar size, weight and age. The pituitary gland region was first identified on lateral scout and transverse non-contrast images. After localization, water soluble iodinated contrast medium was administered intravenously as a bolus at a dose of 1 ml/lb using a pressure injector at an injection rate of 10 ml/sec and a total of 40 post contrast images of the pitutary gland were acquired. No images were made after 400 seconds...
November 2000: Veterinary Radiology & Ultrasound
J D Cechetto, B J Soltys, R S Gupta
We used quantitative immunogold electron microscopy and biochemical analysis to evaluate the subcellular distribution of Hsp60 in rat tissues. Western blot analysis, employing both monoclonal and polyclonal antibodies raised against mammalian Hsp60, shows that only a single 60-kD protein is reactive with the antibodies in brain, heart, kidney, liver, pancreas, pituitary, spleen, skeletal muscle, and adrenal gland. Immunogold labeling of tissues embedded in the acrylic resin LR Gold shows strong labeling of mitochondria in all tissues...
January 2000: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
No abstract text is available yet for this article.
December 1999: Clinical Endocrinology
Z M Xie, Q F Mao, M H Xu, P D Gu, Z J Xie
The intrinsic nature of rthymic release of luteinizing hormone (LH) of isolated human and rat anterior pituitary gland reported independently by Macro Gambacciani and Xie in 1987 can be more directly demonstrated by a computer programme of Time Series-HSY Hidden Periodic Analytic Approach for continuous monitoring the LH output of the perfusate from a perfusion system with in vitro anterior pituitary of SD female rat. The results are as follows: (1) Under various reproductive conditions the average frequency (min/cycle) and amplitude (ng/ml) of the intrinsic rhythm of LH release were quite different: In proestrous group the frequency and amplitude were the highest, being intermediate in the ovariectomized group and lowest in the lactation group...
December 1997: Sheng Li Xue Bao: [Acta Physiologica Sinica]
J Dusková, C Povýsil, V Schreiber
OBJECTIVE: A model of estrogen (E)-induced rat anterior pituitary hyperplasia blocked partly by thyroid hormones (estradiol plus thyreoidin [ET]) and nearly completely by lisuride (estradiol plus lisuride [EL]) and thyreoidin plus lisuride combination (estradiol plus thyreoidin plus lisuride [ETL]) was used to test a computer image analysis program, LUCIA, for argyrophilic nucleolar organizer region (AgNOR) evaluation. STUDY DESIGN: Nuclear and AgNOR area were measured in more than 700 cells in each experimental group...
February 1997: Analytical and Quantitative Cytology and Histology
S E Hughes, P A Hall
BACKGROUND: The fibroblast growth factors (FGFs) and their receptors have a wide range of biologic actions in a variety of systems. The best characterized are the prototypical acidic and basic FGFs, both of which have the property of binding to the flg gene product, fibroblast growth factor receptor-1/FGFR-1. Although much is known at the molecular level, the available information about the in vivo distribution of FGFs and their receptors in human tissues is limited. Detailed characterization of the spatial distribution of ligands and receptors is a necessary prerequisite for understanding their function...
August 1993: Laboratory Investigation; a Journal of Technical Methods and Pathology
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