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https://www.readbyqxmd.com/read/29790729/prenatal-phthalates-maternal-thyroid-function-and-risk-of-attention-deficit-hyperactivity-disorder-in-the-norwegian-mother-and-child-cohort
#1
Stephanie M Engel, Gro D Villanger, Rachel C Nethery, Cathrine Thomsen, Amrit K Sakhi, Samantha S M Drover, Jane A Hoppin, Pal Zeiner, Gun Peggy Knudsen, Ted Reichborn-Kjennerud, Amy H Herring, Heidi Aase
BACKGROUND: There is growing concern that phthalate exposures may have an impact on child neurodevelopment. Prenatal exposure to phthalates has been linked with externalizing behaviors and executive functioning defects suggestive of an attention-deficit hyperactivity disorder (ADHD) phenotype. OBJECTIVES: We undertook an investigation into whether prenatal exposure to phthalates was associated with clinically confirmed ADHD in a population-based nested case-control study of the Norwegian Mother and Child Cohort (MoBa) between the years 2003 and 2008...
May 10, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29787340/correlation-between-thyroidal-and-peripheral-blood-total-t-cells-cd8-t-cells-and-cd8-t-regulatory-cells-and-t-cell-reactivity-to-calsequestrin-and-collagen-xiii-in-patients-with-graves-ophthalmopathy
#2
Farah Al-Ansari, Hooshang Lahooti, Leanne Stokes, Senarath Edirimanne, Jack Wall
Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+  T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role for autoimmunity against CollXIII has also been suggested. In this study, we aimed to investigate correlations between some thyroidal and peripheral blood T-cell subsets and thyroidal T-cell reactivity against CASQ1 and CollXIII in patients with GO...
May 22, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29783245/-epidemiological-features-of-parasitary-invasis-in-women-of-reproductive-age-with-disorders-of-reproductive-health
#3
Valentyna О Sklyarova
OBJECTIVE: The aim: The purpose of this study is to analyze the frequency and structure of parasitic lesion in women with reproductive health disorders. PATIENTS AND METHODS: Materials and methods: The immune-enzyme method tested immunoglobulins IgG to ascaris, lamblia, toxocara. Determination of the presence of pinworm eggs (sticky tape and perianal scrape method) and ascarid (methods of K.Cato, F.Fueleborna and E.S.Schulman). RESULTS: Results: In women with complicated obstetric anamnesis, parasitic invasions occurred in (52...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29779043/glis1-3-transcription-factors-critical-roles-in-the-regulation-of-multiple-physiological-processes-and-diseases
#4
REVIEW
Anton M Jetten
Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone biosynthesis, spermatogenesis, and the maintenance of normal kidney functions...
May 19, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29777250/prevalence-of-temporomandibular-disorders-in-patients-with-hashimoto-thyroiditis
#5
Alina Grozdinska, Elisabeth Hofmann, Matthias Schmid, Ursula Hirschfelder
OBJECTIVES: Autoimmune thyroid disease (AITD), also known as Hashimoto thyroiditis (HT), is a degenerative inflammatory disease with high prevalence among women and has been associated with fibromyalgia and widespread chronic pain. The goal was to determine the frequency of temporomandibular disorders (TMD) in patients with HT. METHODS: In all, 119 women (age 19-60 years) were divided into a study (52 women diagnosed with HT) and a control (67 healthy individuals, of which 15 were excluded) group...
May 17, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/29774380/-thyroid-and-pregnancy
#6
REVIEW
K A Iwen, H Lehnert
During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. This article summarizes the most important diagnostic and therapeutic aspects before, during and after pregnancy...
May 17, 2018: Der Internist
https://www.readbyqxmd.com/read/29772544/antigen-specific-therapy-of-graves%C3%A2-disease-and-orbitopathy-by-induction-of-tolerance
#7
Martin Ungerer, Julia Fabbender, Hans-Peter Holthoff
Graves´ disease is an autoimmune disorder, which is characterized by stimulatory antibodies targeting the human thyrotropin receptor (TSHR), resulting in hyperthyroidism and multiple organ damage. The disease can be modelled in mice using adenoviral immunizations with the extracellular A subunit of the TSHR, which induces a long-term stable disease state. TSHR binding cAMP-stimulatory antibodies, thyroid enlargement, elevated serum thyroxin levels, tachycardia, cardiac hypertrophy and orbitopathy are observed in these Ad-TSHR-immunized mice...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29768385/low-pg-i-ii-ratio-as-a-marker-of-atrophic-gastritis-association-with-nutritional-and-metabolic-status-in-healthy-people
#8
Weiwei Su, Bin Zhou, Guangming Qin, Zhihao Chen, Xiaoge Geng, Xiaojun Chen, Wensheng Pan
A low pepsinogen (PG) I/II ratio can be used to detect atrophic gastritis (AG). Recent research has found that the PG I/II ratio is associated with several nutritional and metabolic disorders. The aim of this study is to investigate the relationship between the PG I/II ratio and biochemical markers in a Chinese population.In total, 1896 participants in a gastric cancer screening program underwent a health screening test that included assessment of serum pepsinogens. Subjects with PG I/II < 3.0 were considered as having atrophic gastritis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29766725/-the-prevalence-of-type-2-diabetes-mellitus-in-patients-with-autoimmune-thyroiditis-in-hypothyroid-stadium
#9
Štefan Sotak, Ivica Lazúrová, Marek Felšöci, Božena Nováková, Hedviga Wagnerová
INTRODUCTION: Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (DM2T) are the two most common endocrinological diseases worldwide. The relationship between T1DM and autoimmune thyreopathies is known and described, but the relationship between thyreopathies and diabetes type 2 is not clarified sufficiently through that studies manifest increasingly the connection between them. OBJECTIVE: Investigate the prevalence of DM2T in patients with AIT in hypothyroid stadium and compare with common population and investigate a possible association between thyroid and glucose metabolism parameters...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29765437/evaluation-of-ovarian-reserve-in-women-with-overt-or-subclinical-hypothyroidism
#10
Ferit Kerim Kucukler, Umit Gorkem, Yasin Simsek, Ramazan Kocabas, Serdar Guler
Introduction: Thyroid dysfunction is among the most common autoimmune disorders in women of reproductive age. Previous studies have shown the association between autoimmune thyroid disease (AITD) and infertility. Anti-Müllerian hormone (AMH) is secreted by granulosa cells and is a useful marker for assessment of ovarian reserve. In the present study, we sought to evaluate the ovarian reserves of women with autoimmune thyroid disorder by measurement of AMH values. Material and methods: This prospective study included women with newly diagnosed AITD aged between 20 and 40 years...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764405/urinary-iodine-concentration-and-thyroid-volume-of-pregnant-women-attending-antenatal-care-in-two-selected-hospitals-in-ashanti-region-ghana-a-comparative-cross-sectional-study
#11
Daniel Gyamfi, Yaw Amo Wiafe, Kwabena Owusu Danquah, Ernest Adankwah, Gertrude Akua Amissah, Angela Odame
BACKGROUND: Iodine deficiency is a major public health problem affecting people worldwide, particularly pregnant women. Iodine requirements increase substantially during pregnancy making pregnant women vulnerable to iodine deficiency and its disorders such as abortions, stillbirths and pregnancy goitre as well as congenital abnormalities, cretinism and mental retardation in their children. The primary aim of this study was to evaluate the prevalence of iodine deficiency and goitre among pregnant women attending antenatal sessions at two selected hospitals in Ashanti region, Ghana...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29764026/-advances-in-postoperative-thyroid-stimulating-hormone-suppression-therapy-in-females-with-thyroid-cancer
#12
F Song, H L Yi
Differentiated thyroid cancer is the most common malignant carcinoma in female population.Postoperative long-term thyroid-stimulating hormone(TSH) suppression therapy can reduce the risk of recurrence for differentiated thyroid cancer and control the progress of the disease, but it also induces simultaneously subclinical hypothyroidism and imposes negative effect on female. In addition to cardiovascular disease, TSH suppression therapy can lead to the alteration of sex hormone metabolism, menstrual disorder, poor influence on pregnancy and osteoporosis...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29763379/hypothyroidism-after-radiation-therapy-for-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#13
Peter D Inskip, Lene H S Veiga, Alina V Brenner, Alice J Sigurdson, Evgenia Ostroumova, Eric J Chow, Marilyn Stovall, Susan A Smith, Rita E Weathers, Wendy Leisenring, Leslie L Robison, Gregory T Armstrong, Charles A Sklar, Jay H Lubin
While thyroid cancer risks from exposure to ionizing radiation early in life are well characterized quantitatively, the association of radiation with nonmalignant, functional thyroid disorders has been less studied. Here, we report on a risk analysis study of hypothyroidism with radiation dose to the thyroid gland and the hypothalamic-pituitary axis among survivors of childhood cancer. Utilizing data from the Childhood Cancer Survivor Study, a cohort of 14,364 five-year survivors of childhood cancer diagnosed at 26 hospitals in the U...
May 15, 2018: Radiation Research
https://www.readbyqxmd.com/read/29762250/abnormal-expression-of-ephrin-a5-affects-brain-development-of-congenital-hypothyroidism-rats
#14
Guihai Suo, Feifei Shen, Baolan Sun, Honghua Song, Meiyu Xu, Youjia Wu
EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed the characteristics of ephrin-A5 expression in the hippocampus of CH rats. Our study revealed that ephrin-A5 expression was downregulated by thyroid hormone deficiency in the developing hippocampus and hippocampal neurons in rats...
May 14, 2018: Neuroreport
https://www.readbyqxmd.com/read/29761266/evaluation-of-thyroid-gland-as-an-organ-at-risk-after-breast-cancer-radiotherapy-a-systematic-review-and-meta-analysis
#15
REVIEW
L Darvish, M Ghorbani, S Hosseini Teshnizi, N Roozbeh, F Seif, M Reza Bayatiani, C Knaup, A Amraee
BACKGROUND: Radiotherapy can often lead to thyroid dysfunction. Some studies demonstrated that treatment of breast cancer by RT can expose thyroid gland to high doses of radiation. The aim of this systematic review is to evaluate consideration of thyroid gland as an organ at risk. METHODS: In this systematic review and meta-analysis to select initial studies, a comprehensive search by two independent reviewers was performed. Electronical databases following: Web of Science, Google Scholar, Scopus, PubMed, Elsevier, Embase, ProQuest and Persian databases such as Iranmedex, Magiran, and SID were searched...
May 14, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29759035/a-novel-missense-mutation-in-slc5a5-gene-in-a-sudanese-family-with-congenital-hypothyroidism
#16
Yui Watanabe, Reham Shareef Ebrhim, Mohamed A Abdullah, Roy E Weiss
Thyroid hormone synthesis requires the presence of iodide. The sodium iodide symporter (NIS) is a glycoprotein which mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). The proposita is a 28-year-old female whose origin is the North Sudan where neonatal screening for CH is not available. She presented with severe constipation and a goiter at the age of 40 days. Laboratory testing confirmed CH and she was started on levothyroxine (L-T4)...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#17
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29748035/direct-correlation-between-serum-homocysteine-level-and-insulin-resistance-index-in-patients-with-subclinical-hypothyroidism-does-subclinical-hypothyroidism-increase-the-risk-of-diabetes-and-cardio-vascular-disease-together
#18
Anahita Ebrahimpour, Mostafa Vaghari-Tabari, Durdi Qujeq, Soheila Moein, Zoleikha Moazezi
BACKGROUND: Subclinical hypothyroidism known as mild thyroid disorder without significant sign and symptoms. The correlation between subclinical hypothyroidism and some of cardiovascular disease risk factors such as serum lipids, homocysteine levels and also insulin resistance index is not well established and the current study was conducted to clarify this issue. METHODS AND MATERIALS: Seventy four patients with mild elevation in levels of thyroid stimulating hormone (TSH) along with normal levels of T3 and T4 were selected as patients group and 74 age and sex matched individuals were selected as healthy control group...
May 5, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29742977/the-thyroid-hormone-receptors-regulate-the-expression-of-micrornas-with-key-roles-in-skin-homeostasis
#19
Lidia Ruiz-Llorente, Constanza Contreras-Jurado, Mónica Martínez-Fernández, Jesus Maria Paramio, Ana Aranda
BACKGROUND: MicroRNAs (miRNAs) play a unique role in posttranscriptional regulation of gene expression and control different aspects of skin development, homeostasis and disease. Although it is generally accepted that thyroid hormones signaling is important in skin pathophysiology, the role of their nuclear receptors (TRs) in cutaneous miRNA expression has yet to be explored. METHODS: We have used RNAseq to compare the skin miRnome of wild-type mice and genetically modified mice lacking both TRα1 and TRβ, the main thyroid hormone binding isoforms...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29739340/mutation-analysis-of-slc26a4-pendrin-gene-in-a-brazilian-sample-of-hearing-impaired-subjects
#20
Renata Watanabe Nonose, Karina Lezirovitz, Maria Teresa Balester de Mello Auricchio, Ana Carla Batissoco, Guilherme Lopes Yamamoto, Regina Célia Mingroni-Netto
BACKGROUND: Mutations in the SLC26A4 gene are associated with Pendred syndrome and autosomal recessive non-syndromic deafness (DFNB4). Both disorders have similar audiologic characteristics: bilateral hearing loss, often severe or profound, which may be associated with abnormalities of the inner ear, such as dilatation of the vestibular aqueduct or Mondini dysplasia. But, in Pendred syndrome (OMIM #274600), with autosomal recessive inheritance, besides congenital sensorineural deafness, goiter or thyroid dysfunctions are frequently present...
May 8, 2018: BMC Medical Genetics
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