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https://www.readbyqxmd.com/read/28938739/sequence-variants-of-khdrbs1-as-high-penetrance-susceptibility-risks-for-primary-ovarian-insufficiency-by-mis-regulating-mrna-alternative-splicing
#1
Binbin Wang, Lin Li, Ying Zhu, Wei Zhang, Xi Wang, Beili Chen, Tengyan Li, Hong Pan, Jing Wang, Kehkooi Kee, Yunxia Cao
STUDY QUESTION: Does a novel heterozygous KHDRBS1 variant, identified using whole-exome sequencing (WES) in two patients with primary ovarian insufficiency (POI) in a pedigree, cause defects in mRNA alternative splicing? SUMMARY ANSWER: The heterozygous variant of KHDRBS1 was confirmed to cause defects in alternative splicing of many genes involved in DNA replication and repair. WHAT IS KNOWN ALREADY: Studies in mice revealed that Khdrbs1 deficient females are subfertile, which manifests as delayed sexual maturity and significantly reduced numbers of secondary and pre-antral follicles...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938686/incidence-and-clearance-of-oral-human-papillomavirus-infection-a-population-based-cohort-study-in-rural-china
#2
Chaoting Zhang, Fangfang Liu, Yaqi Pan, Qiuju Deng, Xiang Li, Zhonghu He, Mengfei Liu, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke
The natural history of oral human papillomavirus (HPV) infection which is linked with the increased incidence of oropharyngeal squamous cell cancer (OPSCC) has been incompletely studied. Oral swab specimens and questionnaire data were obtained bi-annually for up to 6 visits from 4314 healthy adults aged 25-69 in rural Anyang, China. HPV infection status was evaluated with PCR-based sequencing. Participants with at least two consecutive valid HPV results within the study period were included in the incidence and clearance analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938685/a-case-control-study-of-the-association-between-the-egfr-gene-and-glioma-risk-in-a-chinese-han-population
#3
Mengdan Yan, Jingjie Li, Na He, Xugang Shi, Shuli Du, Bin Li, Tianbo Jin
The Epidermal Growth Factor Receptor gene has been reported to be involved in the progression of gliomas which is one of the deadliest primary brain tumors in humans. To determine potential association between EGFR and glioma risk, we performed a case-control study with 394 glioma patients and 298 cancer-free controls in which captured a total of 8 tag single nucleotide polymorphisms of EGFR gene from Xi'an, China. SPSS 19.0 statistical packages, χ(2) test, genetic model analysis and SHEsis software platform were analyzed s the variants in EGFR gene associations with glioma risk...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938682/mental-health-of-the-old-and-new-generation-migrant-workers-in-china-who-are-at-greater-risk-for-psychological-distress
#4
Bao-Liang Zhong, Sandra S M Chan, Tie-Bang Liu, Dong Jin, Chi-Yi Hu, Helen F K Chiu
Rural-to-urban migrant workers (MWs) are a large vulnerable population in China and, recently, the new-generation MWs (those born in 1980 or later) have become the majority of this population. Examining difference in the epidemiology of poor mental health between the new- and old-generation (those born before 1980) MWs would facilitate mental health promotion efforts. However, very few related studies are available and they produced conflicting findings. This study investigated intergenerational difference in prevalence and correlates of psychological distress (PD) in MWs...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938663/transcatheter-hepatic-arterial-chemoembolization-and-sorafenib-for-hepatocellular-carcinoma-a-meta-analysis-of-randomized-double-blind-controlled-trials
#5
Jun Li, Wenhui Liu, Wenhua Zhu, Yinqiao Wu, Benyan Wu
We performed a meta-analysis of transcatheter hepatic arterial chemoembolization (TACE) combined with sorafenib for hepatocellular carcinoma (HCC), which included 4 double-blind, randomized controlled trials (RCTs) that investigated the effects of TACE combined with sorafenib (experimental groups) on time to disease progression (TTP), overall survival (OS), and various sorafenib-related adverse events, compared to those in the placebo (control) groups. A total of 877 HCC cases from 14 countries, including China and the USA, were included in our meta-analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938659/prognostic-value-of-the-long-noncoding-rna-hottip-in-human-cancers
#6
Wei Li, Na Li, Xinmei Kang, Ke Shi, Qiong Chen
Human Homeobox A transcript at the distal tip (HOTTIP) is a putative oncogene in solid tumors. We performed a meta-analysis to investigate the association between HOTTIP expression and clinical outcomes in cancer patients. Eligible studies were collected from a literature search of the online electronic databases of Embase, Web of Science, PubMed and the China National Knowledge Infrastructure (up to January 2, 2017). Fixed-effects models were used to compute pooled odds ratios (ORs) and hazard ratios (HRs)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938658/comparison-of-direct-sequencing-and-amplification-refractory-mutation-system-for-detecting-epidermal-growth-factor-receptor-mutation-in-non-small-cell-lung-cancer-patients-a-systematic-review-and-meta-analysis
#7
Qi Feng, Zu-Yao Yang, Jia-Tong Zhang, Jin-Ling Tang
BACKGROUND: Direct sequencing and amplification refractory mutation system (ARMS) are commonly used to detect epidermal growth factor receptor (EGFR) mutation status in patients with non-small-cell lung cancer to inform the decision-making on tyrosine kinase inhibitors treatment. This study aimed to systematically compare the two methods in terms of the rate of detected mutations and the association of detected mutations with clinical outcomes. MATERIAL AND METHODS: PubMed, EMBASE, China National Knowledge Infrastructure (in Chinese) and Wanfang database (in Chinese) were searched to identify relevant studies...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938630/prognostic-role-of-neutrophil-lymphocyte-ratio-in-patients-with-glioma
#8
Jing Zhang, Sunfu Zhang, Yanlin Song, Min He, Qingqing Ren, Chaoyue Chen, Zhiyong Liu, Yunhui Zeng, Jianguo Xu
The purpose of this study was to evaluate the prognostic role of neutrophil lymphocyte ratio (NLR) in patients with glioma. PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure were searched for relevant literature. The study and patient characteristics were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of NLR in patients with glioma. Subgroup analysis and sensitivity analysis were also performed. Six studies with 1,021 patients were included...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938625/predictive-value-of-preoperative-retinal-nerve-fiber-layer-thickness-for-postoperative-visual-recovery-in-patients-with-chiasmal-compression
#9
Jing Zhang, Sunfu Zhang, Yanlin Song, Chenjing Zhu, Min He, Qingqing Ren, Baoyin Shan, Ziqiong Wang, Yunhui Zeng, Jianguo Xu
The aim of this study was to evaluate the predictive role of preoperative retinal nerve fiber layer (RNFL) thickness for postoperative visual recovery in patients with chiasmal compression through performing a meta-analysis. PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure were searched for relevant studies. The study and patient characteristics were extracted. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the predictive value of RNFL thickness...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938579/the-effects-of-air-pollution-on-mortality-and-clinicopathological-features-of-esophageal-cancer
#10
Xiaochen Huang, Shanghui Guan, Jiangfeng Wang, Linli Zhao, Yibin Jia, Zilong Lu, Cuiping Yin, Shengsi Yang, Qingxu Song, Lihui Han, Cong Wang, Jingyi Li, Wei Zhou, Xiaolei Guo, Yufeng Cheng
This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM10), SO2, NO2 and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM10 (p=0.046) and NO2 (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM10 was still an independent risk factor that increased esophageal cancer mortality rates...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938562/the-effect-of-pre-pregnancy-body-mass-index-and-excessive-gestational-weight-gain-on-the-risk-of-gestational-diabetes-in-advanced-maternal-age
#11
Beibei Dong, Hong Yu, Qiong Wei, Mengmeng Zhi, Chunhua Wu, Xiangyun Zhu, Ling Li
BACKGROUND AND PURPOSE: With the popularization of a two-child policy in China, the number of pregnant women of advanced maternal age will increase steadily. We aimed to assess the association between pre-pregnancy body mass index (BMI) and weight gain in the first and second trimester and the risk of gestational diabetes (GDM) in the advanced maternal age group and control group defined as maternal age of 20-35 years. RESULTS: The risk of GDM for obesity before pregnancy was 2...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938539/dissemination-of-macrolides-fusidic-acid-and-mupirocin-resistance-among-staphylococcus-aureus-clinical-isolates
#12
Xingmei Liu, Shanshan Deng, Jinwei Huang, Yaling Huang, Yu Zhang, Qin Yan, Yanhong Wang, Yanyue Li, Chengfu Sun, Xu Jia
As an increasingly common cause of skin infections worldwide, the prevalence of antibiotic-resistant Staphylococcus aureus (S. aureus) across China has not been well documented. This literature aims to study the resistance profile to commonly used antibiotics, including macrolides, fusidic acid (FA) and mupirocin, and its relationship to the genetic typing in 34 S. aureus strains, including 6 methicillin-resistant S. aureus (MRSA), isolated from a Chinese hospital. The MIC results showed 27 (79.4%), 1 (2.9%) and 6 (17...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938484/long-noncoding-rnas-potential-regulators-involved-in-the-pathogenesis-of-polycystic-ovary-syndrome
#13
Yu-Dong Liu, Ying Li, Shu-Xian Feng, De-Sheng Ye, Xin Chen, Xing-Yu Zhou, Shi-Ling Chen
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age, and its etiology remains poorly understood. Altered activities of long noncoding RNAs (lncRNAs) have been associated with human diseases and development. However, the roles of lncRNAs are unknown in reproductive medicine. We investigated the potential role of lncRNAs in the pathogenesis of PCOS, using human granulosa cells (GCs) and the KGN cell line. We used microarrays to compare lncRNA expression profiles in GCs from 7 PCOS patients and 7 matched women...
August 31, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938243/creating-a-learning-culture-for-medical-consortia-in-china
#14
Guozhong He, Zimin Chen
In China's recent health care reforms, both individuals and organizations have shown an ever-growing desire and demand for new knowledge and skills. A health care delivery system (HCDS) should explore new ways for creating a learning organization (LO) and should organically combine HCDS culture construction with the LO construction to build a cultural atmosphere that is conducive to the development of the LO. This article describes the implementation phase, characteristics, and realization strategy of an HCDS construction for the ultimate purpose of enhancing HCDS cohesion, solidarity, and sustainable development...
September 21, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28938210/contribution-of-industrial-density-and-socioeconomic-status-to-the-spatial-distribution-of-thyroid-cancer-risk-in-hangzhou-china
#15
Xufeng Fei, Zhaohan Lou, George Christakos, Qingmin Liu, Yanjun Ren, Jiaping Wu
BACKGROUND: The thyroid cancer (TC) incidence in China has increased dramatically during the last three decades. Typical in this respect is the case of Hangzhou city (China), where 7147 new TC cases were diagnosed during the period 2008-2012. Hence, the assessment of the TC incidence risk increase due to environmental exposure is an important public health matter. METHODS: Correlation analysis, Analysis of Variance (ANOVA) and Poisson regression were first used to evaluate the statistical association between TC and key risk factors (industrial density and socioeconomic status)...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938200/atmospheric-deposition-of-mercury-and-cadmium-impacts-on-topsoil-in-a-typical-coal-mine-city-lianyuan-china
#16
Jie Liang, Chunting Feng, Guangming Zeng, Minzhou Zhong, Xiang Gao, Xiaodong Li, Xinyue He, Xin Li, Yilong Fang, Dan Mo
Mercury (Hg) and cadmium (Cd) in the atmosphere from coal combustion emissions play an important role in soil pollution. Therefore, the purposes of this study were to quantitatively evaluate the atmospheric Hg and Cd deposition and to determine the influence of atmospheric deposition on Hg and Cd contents in surface soil in a typical coal mine city. Atmospheric deposition samples were collected from May 2015 to May 2016 at 17 sites located in industrial, agricultural and forest areas in the Lianyuan city. Atmospheric Hg and Cd deposition fluxes in the different land use types showed high variability...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28938149/the-genetic-influence-in-fluorosis
#17
REVIEW
Sreemanta Pramanik, Depanwita Saha
Fluorosis, caused by ingestion of excess fluoride, is endemic in at least 25 countries across the globe, China and India being the worst affected among them. Dental, skeletal and non-skeletal are the major types of fluorosis affecting millions of people in these countries. A number of genetic epidemiological studies carried out by investigators have shown the evidence for association between genetic polymorphisms in candidate genes and differences in the susceptibility pattern of different types of fluorosis among individuals living in the same community and having the same environmental exposure...
September 15, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28938133/genetic-polymorphisms-for-19-x-str-loci-of-sichuan-han-ethnicity-and-its-comparison-with-chinese-populations
#18
Guanglin He, Ye Li, Xing Zou, Mengge Wang, Pengyu Chen, Miao Liao, Jin Wu
X-chromosomal short tandem repeats (X-STRs) can be serviced as a complementary tool in forensic deficiency cases and other complicated kinship identification. To investigate the genetic variation of the western Chinese Han population, genetic polymorphisms of 19 X-STR loci (DXS8378, DXS7423, DXS10148, DXS10159, DXS10134, DXS7424, DXS10164, DXS10162, DXS7132, DXS10079, DXS6789, DXS101, DXS10103, DXS10101, HPRTB, DXS6809, DXS10075, DXS10074 and DXS10135) included in the AGCU X19 PCR amplification kit were obtained from 201 Chinese Han individuals (108 females and 93 males) residing in Sichuan province, western China...
September 15, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28938020/seasonal-variations-in-carbon-nitrogen-and-phosphorus-concentrations-and-c-n-p-stoichiometry-in-different-organs-of-a-larix-principis-rupprechtii-mayr-plantation-in-the-qinling-mountains-china
#19
Hailiang Li, M James C Crabbe, Fuli Xu, Weiling Wang, Lihui Ma, Ruilong Niu, Xing Gao, Xingxing Li, Pei Zhang, Xin Ma, Haikui Chen
Understanding how concentrations of elements and their stoichiometry change with plant growth and age is critical for predicting plant community responses to environmental change. We used long-term field experiments to explore how the leaf, stem and root carbon (C), nitrogen (N) and phosphorous (P) concentrations and their stoichiometry changed with growth and stand age in a L. principis-rupprechtii Mayr. plantation from 2012-2015 in the Qinling Mountains, China. Our results showed that the C, N and P concentrations and stoichiometric ratios in different tissues of larch stands were affected by stand age, organ type and sampling month and displayed multiple correlations with increased stand age in different growing seasons...
2017: PloS One
https://www.readbyqxmd.com/read/28937792/timeliness-of-measles-laboratory-reporting-and-factors-associated-with-delays-zhejiang-province-china-2009-2015
#20
Hanqing He, Rui Yan, Chunhong Fan, Fangyuan Jing, Ye Ding
In 2006, China targeted measles for elimination by 2012, but the goal was not achieved. In line with this goal, the timeliness of measles laboratory reporting should be evaluated to improve efficiency in implementing control measures. Laboratory-confirmed suspected measles cases reported to the measles surveillance system in Zhejiang Province, China, from 2009 to 2015 were collected. Three reporting periods were defined: transport duration (period from serum collected to serum received in lab), analysis duration (period from serum received to the result being reported), and total reporting duration...
September 22, 2017: Health Security
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