Antônio Duarte Pagano, Natiéli Machado Gonçalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kütter, Antônio Sérgio Varela Junior, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Vianna Dos Reis, Patrícia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Härter Remião, Vinicius Farias Campos
This study aimed to analyze the toxic effects of Roundup Transorb® on the endangered Neotropical annual killifish Austrolebias charrua through the assessment of molecular and biochemical biomarkers. The fish was collected in temporary ponds and exposed to environmentally realistic concentrations of the herbicide (5 mg. L-1 for 96 h). The production of ROS, lipid peroxidation, DNA damage, and membrane fluidity were evaluated in the blood cells by flow cytometry. The mRNA expression of the antioxidant-related genes sod2, cat, gstα, atp1a1, gclc, and ucp1 across the brain, liver, and gills was quantified...
November 15, 2023: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP