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Benno Ehrl, Emmanuel O Mogusu, Kyoungtea Kim, Heike Hofstetter, Joel A Pedersen, Martin Elsner
Bacterial uptake of charged organic pollutants such as the widely used herbicide glyphosate is typically attributed to active transporters, whereas passive membrane permeation as an uptake pathway is usually neglected. For 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) liposomes, pH-dependent membrane permeation coefficients (Papp) of glyphosate, determined by nuclear magnetic resonance (NMR) spectroscopy, varied from Papp(pH 7.0) = 3.7 (+/-0.3) × 10-7 m∙s-1 to Papp(pH 4.1) = 4.2 (+/-0.1) × 10-6 m∙s-1...
May 23, 2018: Environmental Science & Technology
C Ruiz de Arcaute, S Soloneski, M L Larramendy
We analyzed the acute toxicity of the 48% glyphosate (GLY)-based Credit® , the 57.71% dicamba (DIC)-based Kamba® , and the 83.5% 2,4-dichlorophenoxyacetic acid (2,4-D)-based Weedar® Full, alone and as mixtures on the fish Cnesterodon decemmaculatus. Mortality revealed the LC50 96h values of 91.73 mg L-1 (range: 86.80-98.00 mg L-1 ), 1401.57 mg L-1 (range: 1243.78-1527.35) and 678.04 mg L-1 (range: 639.35-718.04 mg L-1 ) for GLY, DIC and 2,4-D, respectively. Mean values for the toxic unit (TU) that induced 50% mortality (TU50 96h ) of fish exposed to equitoxic mixtures were 1...
May 19, 2018: Environmental Pollution
Yongsoo Cho, Byeongjo Chun, Jeongmi Moon
This study aimed to investigate whether the quick Sequential Organ Failure Assessment (qSOFA) score at emergency department (ED) presentation can help improve the risk assessment of glyphosate-surfactant herbicide (GlySH) poisoning complications. A total of 150 patients presenting with acute glyphosate herbicide ingestion were enrolled in this retrospective observational study. The qSOFA scores at presentation, ΔqSOFA (calculated by subtracting the worst qSOFA score from 1 hr after admission from the qSOFA score at presentation), baseline characteristics, clinical courses and outcomes were collected and analysed...
May 22, 2018: Basic & Clinical Pharmacology & Toxicology
Alison Vanlaeys, Florine Dubuisson, Gilles-Eric Seralini, Carine Travert
Roundup and Glyphogan are glyphosate-based herbicides containing the same concentration of glyphosate and confidential formulants. Formulants are declared as inert diluents but some are more toxic than glyphosate, such as the family of polyethoxylated alkylamines (POEA). We tested glyphosate alone, glyphosate-based herbicide formulations and POEA on the immature mouse Sertoli cell line (TM4), at concentrations ranging from environmental to agricultural-use levels. Our results show that formulations of glyphosate-based herbicides induce TM4 mitochondrial dysfunction (like glyphosate, but to a lesser extent), disruption of cell detoxification systems, lipid droplet accumulation and mortality at sub-agricultural doses...
May 15, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Bruna De Marchi, Silvio Funtowicz
No abstract text is available yet for this article.
March 2018: Epidemiologia e Prevenzione
Tomas Erban, Martin Stehlik, Bruno Sopko, Martin Markovic, Marcela Seifrtova, Tatana Halesova, Pavel Kovaricek
The broad-spectrum herbicide glyphosate is one of the most widely used pesticides. Both glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), persist in waters; thus, their environmental fates are of interest. We investigated the influence of compost dose, sampling depth, moisture and saturated hydraulic conductivity (Ks ) on the persistence of these substances. The amounts of AMPA quantified by triple quadrupole liquid chromatography-mass spectrometry (LC-QqQ-MS/MS) using isotopically labeled extraction standards were higher than those of glyphosate and differed among the samples...
May 4, 2018: Chemosphere
Yajuan Li, Chuanqi Zhao, Yujuan Wen, Yuanyuan Wang, Yuesuo Yang
In this study, the magnetic reduced graphene oxide (RGO/Fe3 O4 ), with easy separation and high adsorption performance, was prepared and used to treat glyphosate (GLY) contaminated water. GLY adsorption performance of RGO/Fe3 O4 was investigated, and influences of pH, adsorption time, temperature, contaminant concentration, and competing anions were analyzed. Moreover, the adsorption mechanism was discussed in the light of several characterization methods, including scanning electron microscopy (SEM), energy dispersive spectrum (EDS), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS)...
May 16, 2018: Environmental Science and Pollution Research International
F Avdatek, Y O Birdane, R Türkmen, H H Demirel
In this study, the reproductive impacts of being exposed to glyphosate (GLF) and the protective impacts of resveratrol (RES) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES, group II received normal feed containing 20 mg kg-1 daily-1 RES, group III received normal feed containing 375 mg kg-1 daily-1 GLF, and group IV received normal feed containing 375 mg kg-1 daily-1 GLF+20 mg kg-1 daily-1 RES. GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats...
May 14, 2018: Andrologia
Steven D Forsythe, Mahesh Devarasetty, Thomas Shupe, Colin Bishop, Anthony Atala, Shay Soker, Aleksander Skardal
Introduction: Environmental toxins, such as lead and other heavy metals, pesticides, and other compounds, represent a significant health concern within the USA and around the world. Even in the twenty-first century, a plethora of cities and towns in the U.S. have suffered from exposures to lead in drinking water or other heavy metals in food or the earth, while there is a high possibility of further places to suffer such exposures in the near future. Methods: We employed bioengineered 3D human liver and cardiac organoids to screen a panel of environmental toxins (lead, mercury, thallium, and glyphosate), and charted the response of the organoids to these compounds...
2018: Frontiers in Public Health
Zhi-Qiang Liu, Ming-Ming Lu, Xin-Hong Zhang, Feng Cheng, Jian-Miao Xu, Ya-Ping Xue, Li-Qun Jin, Yuan-Shan Wang, Yu-Guo Zheng
Iminodiacetic acid (IDA) is widely used as an intermediate in the manufacturing of chelating agents, glyphosate herbicides and surfactants. To improve activity and tolerance to the substrate for IDA production, Acidovorax facilis nitrilase was selected for further modification by the gene site saturation mutagenesis method. After screened by a two-step screening method, the best mutant (Mut-F168V/T201N/S192F/M191T/F192S) was selected. Compared to the wild-type nitrilase, Mut-F168V/T201N/S192F/M191T/F192S showed 136% improvement in specific activity...
May 9, 2018: International Journal of Biological Macromolecules
Gabriela A Altamirano, Melisa B Delconte, Ayelen L Gomez, Paola Ingaramo, Verónica L Bosquiazzo, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated...
May 7, 2018: Food and Chemical Toxicology
Alison Connolly, Michelle Leahy, Kate Jones, Laura Kenny, Marie A Coggins
OBJECTIVES: Glyphosate is the highest volume herbicide used globally and has recently been classified as a 2 A 'probably carcinogenic to humans' by the International Agency for Research on Cancer (IARC). There is limited data to evaluate the public health impacts from glyphosate exposure. The objective of this study is to conduct an exploratory glyphosate exposure assessment study among Irish adults, who were non-occupational users of glyphosate. STUDY DESIGN: A convenient sampling method was used, collecting one first morning void spot urine sample from each participant...
May 2, 2018: Environmental Research
Johannes Kulenkampff, Madeleine Stoll, Marion Gründig, Alexander Mansel, Johanna Lippmann-Pipke, Michael Kersten
Phenoxyalkanoic acids like the 4-chloro-2-methylphenoxyacetic acid (MCPA) are the second highest used xenobiotic herbicides worldwide after glyphosate because of their apparently favorable environmental properties. Experimental batch equilibration data suggested a reduced Cu adsorption efficiency with the soil mineral goethite below pH 6 in presence of MCPA. This has been verified by advanced surface complexation adsorption modelling involving dissolved Cu-MCPA complexation constants. Positron emission tomography is a non-invasive molecular imaging method for time-resolved three-dimensional information commonly applied on non-retarded tracers in soil core scale experiments...
May 4, 2018: Scientific Reports
Sarah Morran, Marcelo L Moretti, Caio A Brunharo, Albert J Fischer, Bradley D Hanson
BACKGROUND: In California specialty cropping systems such as vineyards and orchards, Echinochloa colona is present as a summer annual weed. It is able to germinate throughout the growing season whenever favorable conditions are present, and management relies heavily on glyphosate applications. Glyphosate-resistant (GR) E. colona biotypes are present in the state, but the levels of resistance observed suggest that there may be differences in mechanisms of resistance among populations. RESULTS: E...
May 2, 2018: Pest Management Science
Mārtiņš Jansons, Iveta Pugajeva, Vadims Bartkevičs
A sensitive LC-MS/MS method for the determination of glyphosate in beer has been developed, validated, and applied to analyse 100 beer samples from 24 different producers and distributors in Latvia. The selected samples represented most beer brands and varieties sold in local supermarkets. Different procedures for sample preparation and chromatographic separation were compared. The final version of the method consisted of solid phase extraction, chromatographic separation on aminopropyl stationary phase, and detection using tandem mass spectrometry...
May 2, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Veronika Bókony, Bálint Üveges, Nikolett Ujhegyi, Viktória Verebélyi, Edina Nemesházi, Olivér Csíkvári, Attila Hettyey
Many chemical pollutants have endocrine disrupting effects which can cause lifelong reproductive abnormalities in animals. Amphibians are the most threatened group of vertebrates, but there is little information on the nature and quantity of pollutants occurring in typical amphibian breeding habitats and on the reproductive capacities of amphibian populations inhabiting polluted areas. In this study we investigated the occurrence and concentrations of endocrine disrupting chemicals in the water and sediment of under-studied amphibian breeding habitats in natural, agricultural and urbanized landscapes...
April 13, 2018: Science of the Total Environment
Carolina E Masin, Maia R Lescano, Alba R Rodríguez, José L Godoy, Cristina S Zalazar
In this study, the innocuousness of different biomixtures employed for glyphosate degradation was tested through Eisenia fetida earthworms. Eight biomixtures were prepared with local materials: alfalfa straw (AS), wheat stubble (WS), river waste (RW) and two different soils (A and B). Each biomixture was divided into two equal portions: one without glyphosate application (control substrate) and the other was sprayed with a commercial glyphosate formulation of 1,000 mg glyphosate a.i. kg-1 biomixture (applied substrate)...
April 30, 2018: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Hui Zhan, Yanmei Feng, Xinghui Fan, Shaohua Chen
Glyphosate has emerged as the most widespread herbicide to control annual and perennial weeds. Massive use of glyphosate for decades has resulted in its ubiquitous presence in the environment, and poses a threat to humans and ecosystem. Different approaches such as adsorption, photocatalytic degradation, and microbial degradation have been studied to break down glyphosate in the environment. Among these, microbial degradation is the most effective and eco-friendly method. During its degradation, various microorganisms can use glyphosate as a sole source of phosphorus, carbon, and nitrogen...
April 29, 2018: Applied Microbiology and Biotechnology
Ning Yu, Yun Tong, Danni Zhang, Shanshan Zhao, Xinli Fan, Lihui Wu, Hua Ji
Glyphosate is the active ingredient in numerous herbicide formulations. The roles of glyphosate in embryo-toxicity and neurotoxicity have been reported in human and animal models. Recently, several studies have reported evidence linking neurodevelopmental disorders (NDDs) with gestational glyphosate exposure. However, the role of glyphosate in neuronal development is still not fully understood. Our previous study found that perinatal glyphosate exposure resulted in differential microRNA expression in the prefrontal cortex of mouse offspring...
April 26, 2018: Biochemical and Biophysical Research Communications
Wrobel Michael Hubert
The effects of pure glyphosate and its most popular product (brand name: Roundup) on the secretion of hormones involved in the regulation of myometrial contractions as well as their direct effects on myometrial contractions were examined. Myometrial strips as well as uterine and ovarian cells were taken from cows during the oestrous cycle and they were treated with both compounds at concentrations from their environmental range. Glyphosate stimulated the secretion of oestradiol from granulosa cells while both herbicides increased and decreased oxytocin (OT) and progesterone secretion from luteal cells respectively...
April 26, 2018: Toxicology and Applied Pharmacology
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