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https://www.readbyqxmd.com/read/27836305/age-at-menarche-and-risk-of-major-cardiovascular-diseases-evidence-of-birth-cohort-effects-from-a-prospective-study-of-300-000-chinese-women
#1
Ling Yang, Liming Li, Iona Y Millwood, Sanne A E Peters, Yiping Chen, Yu Guo, Zheng Bian, Xiaofang Chen, Lingli Chen, Shixian Feng, Silu Lv, Zhigang Pang, Mark Woodward, Zhengming Chen
BACKGROUND: Previous studies of mostly Western women have reported inconsistent findings on the association between age at menarche and risk of cardiovascular disease (CVD). Little is known about the association in China where there has been a large intergenerational decrease in women's mean age at menarche. METHODS: The China Kadoorie Biobank recruited 302,632 women aged 30-79 (mean 50.5)years in 2004-8 from 10 diverse regional sites across China. During 7years follow-up, 14,111 incident cases of stroke, 14,093 of coronary heart disease (CHD), and 3200 CVD deaths were reported among 281,491 women who had no prior history of CVD at baseline...
November 4, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27765126/-association-and-interaction-between-age-at-menarche-and-risk-of-diabetes-in-adult-women
#2
H Wang, R Y Hu, J M Zhong, Y J Qian, C M Wang, K X Xie, L L Chen, Z Bian, Y Guo, M Yu, Z M Chen, L M Li
Objective: To explore the associations between age at menarche and diabetes in adult women. Methods: We analyzed the baseline data of 32 364 female participants who were aged 30-79 years and had been enrolled into China Kadoorie Biobank (CKB) study from Tongxiang, Zhejiang province. Multiple logistic regression analysis were used to investigate the putative associations after adjusting for potential confounders. Variables of menarche age and others were added to the logistic regression model to evaluate the multiplicative interaction, respectively...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27665439/the-association-between-sleep-duration-snoring-and-prevalent-type-2-diabetes-mellitus-with-regard-to-gender-and-menopausal-status-the-ckb-study-in-zhejiang-rural-area-china
#3
Hai-Bin Wu, Hao Wang, Ru-Ying Hu, Jie-Ming Zhong, Yi-Jian Qian, Chun-Mei Wang, Kai-Xu Xie, Ling-Li Chen, Wei-Wei Gong, Yu Guo, Zheng Bian, Zheng-Ming Chen, Li-Ming Li, Min Yu
AIMS: To evaluate the association between sleep duration, snoring and diabetes according to gender and menopausal status in rural China. METHODS: The data were part of the baseline survey of China Kadoorie Biobank, from a rural county in the south-east costal Zhejiang province. Participants including 24,027 men and 33,677 women aged 30-79 years were enrolled during 2004-2008. Multivariable logistic regression was used to calculate adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) for diabetes...
September 24, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27649806/parenthood-and-the-risk-of-cardiovascular-diseases-among-0-5-million-men-and-women-findings-from-the-china-kadoorie-biobank
#4
Sanne Ae Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Iona Y Millwood, Shaojie Wang, Liqiu Yang, Yihe Hu, Jiaqiu Liu, Tao Wang, Junshi Chen, Richard Peto, Liming Li, Mark Woodward, Zhengming Chen
BACKGROUND: Women's parity has been associated with risk of cardiovascular disease (CVD). It is unclear, however, whether it reflects biological effects of childbearing or uncontrolled socio-economic and lifestyle factors associated with childrearing. We assessed the association between number of children and incident CVD outcomes separately in women and men. METHODS: In 2004-08, the nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30-79 years from 10 diverse regions...
September 20, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27539338/-prevalence-of-diabetes-and-related-factors-in-pengzhou-city-sichuan-province
#5
Q Sun, X F Chen, X P Wu, G J Luo, J G Li, H Wang, X F Chen, Z Bian, Y Guo
OBJECTIVE: To study the prevalence, treatment and related risk factors of diabetes in Pengzhou city, so as to provide reference for the three-tier related prevention programs. METHODS: Baseline survey of population of Sichuan province from the China Kadoorie Biobank, was used to analyze the prevalence and treatment of diabetes in Pengzhou city. Logistic regression model was used to analyze the influencing factors on diabetes. RESULTS: The prevalence rate of diabetes was 3...
August 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27524817/adiposity-in-relation-to-age-at-menarche-and-other-reproductive-factors-among-300%C3%A2-000-chinese-women-findings-from-china-kadoorie-biobank-study
#6
Ling Yang, Liming Li, Iona Y Millwood, Sarah Lewington, Yu Guo, Paul Sherliker, Sanne Ae Peters, Zheng Bian, Xianping Wu, Min Yu, Huilin Liu, Hongmei Wang, Enke Mao, Junshi Chen, Mark Woodward, Richard Peto, Zhengming Chen
BACKGROUND: Adiposity is increasing rapidly in China but little is known about the relevance to it of women's reproductive factors, which differ inter-generationally and from that in the West. We assess associations of adiposity with life-course reproductive factors in Chinese women. METHODS: In 2004-08, the nationwide China Kadoorie Biobank recruited 303 000 women aged 30-79 (mean 50) years from 10 diverse regions. Multivariable linear regression was used to examine associations of reproductive factors (e...
August 14, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27518676/fruit-consumption-and-cardiovascular-disease-in-china
#7
LETTER
Guo-Chong Chen, Li-Qiang Qin
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518675/fruit-consumption-and-cardiovascular-disease-in-china
#8
LETTER
Eran Kopel
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518674/fruit-consumption-and-cardiovascular-disease-in-china
#9
LETTER
Melvin K Leow
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27518673/fruit-consumption-and-cardiovascular-disease-in-china
#10
LETTER
Huaidong Du, Liming Li, Zhengming Chen
No abstract text is available yet for this article.
August 4, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27470992/association-of-major-depressive-episodes-with-stroke-risk-in-a-prospective-study-of-0-5-million-chinese-adults
#11
Jie Sun, Hongxia Ma, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hongbing Shen, Zhengming Chen, Zhibin Hu, Liming Li
BACKGROUND AND PURPOSE: Although the relationship between depression and stroke risk has been investigated, findings in previous reports were conflicting. The aim of this study was to prospectively examine the effect of major depressive episodes (MDE) on stroke incidence and further assess the potential dose-response relationship between number of depression symptoms and subsequent stroke risk in Chinese population. METHODS: A total of 199 294 men and 288 083 women aged 30 to 79 years without a history of stroke, heart disease, and cancer in the China Kadoorie Biobank cohort were followed from 2004 to 2013...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27437922/association-of-random-plasma-glucose-levels-with-the-risk-for-cardiovascular-disease-among-chinese-adults-without-known-diabetes
#12
Fiona Bragg, Liming Li, Derrick Bennett, Yu Guo, Sarah Lewington, Zheng Bian, Ling Yang, Junshi Chen, Yiping Chen, Rory Collins, Richard Peto, Baoyu Zhu, Jiyuan Yin, Ximin Hu, Liyuan Zhou, Yaxing Pan, Zhengming Chen
Importance: Diabetes is a known risk factor for cardiovascular disease (CVD). Substantial uncertainty remains, however, about the relevance to CVD risk for blood glucose levels below the diabetes threshold. Objective: To examine the association of random plasma glucose (RPG) levels with the risk for major CVD in Chinese adults without known diabetes. Design, Setting, and Participants: This prospective cohort study included 467 508 men and women aged 30 to 79 years with no history of diabetes, ischemic heart disease (IHD), stroke, or transient ischemic attack...
July 20, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27379518/risks-and-population-burden-of-cardiovascular-diseases-associated-with-diabetes-in-china-a-prospective-study-of-0-5-million-adults
#13
Fiona Bragg, Liming Li, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Junshi Chen, Rory Collins, Richard Peto, Chunmei Wang, Caixia Dong, Rong Pan, Jinyi Zhou, Xin Xu, Zhengming Chen
BACKGROUND: In China, diabetes prevalence is rising rapidly, but little is known about the associated risks and population burden of cardiovascular diseases. We assess associations of diabetes with major cardiovascular diseases and the relevance of diabetes duration and other modifiable risk factors to these associations. METHODS AND FINDINGS: A nationwide prospective study recruited 512,891 men and women aged 30-79 y between 25 June 2004 and 15 July 2008 from ten diverse localities across China...
July 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27318909/-major-depressive-disorder-in-relation-with-coronary-heart-disease-and-stroke-in-chinese-adults-aged-30-79-years
#14
C Q Yu, Y P Chen, J Lv, Y Guo, P Sherliker, Z Bian, H Y Zhou, Y L Tan, J S Chen, Z M Chen, L M Li
OBJECTIVE: To investigate the associations of major depressive disorder with coronary heart disease (CHD) and stroke in Chinese adults aged 30-79 years. METHODS: In 2004-2008, China Kadoorie Biobank was conducted in 10 geographically defined regions (5 urban and 5 rural) of China. A total number of 512 891 participants aged 30-79 years were recruited in the baseline survey. A laptop-based electronic questionnaire was administrated face-to-face by trained health workers, collecting the general demographic and socio-economic status, dietary and other lifestyle behaviours (e...
June 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27301456/a-phenome-wide-association-study-of-a-lipoprotein-associated-phospholipase-a2-loss-of-function-variant-in-90-000-chinese-adults
#15
Iona Y Millwood, Derrick A Bennett, Robin G Walters, Robert Clarke, Dawn Waterworth, Toby Johnson, Yiping Chen, Ling Yang, Yu Guo, Zheng Bian, Alex Hacker, Astrid Yeo, Sarah Parish, Michael R Hill, Stephanie Chissoe, Richard Peto, Lon Cardon, Rory Collins, Liming Li, Zhengming Chen
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA2 inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically determined lower Lp-PLA2 METHODS: PLA2G7 V279F (rs76863441) was genotyped in 91 428 individuals randomly selected from the China Kadoorie Biobank of 0.5 M participants recruited in 2004-08 from 10 regions of China, with 7 years' follow-up...
October 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27193915/parenthood-and-the-risk-of-diabetes-in-men-and-women-a-7%C3%A2-year-prospective-study-of-0-5-million-individuals
#16
Sanne A E Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Iona Y Millwood, Fiona Bragg, Xue Zhou, Pengfei Ge, Biyun Chen, Yulian Gao, Yijun Li, Junshi Chen, Liming Li, Mark Woodward, Zhengming Chen
AIMS/HYPOTHESIS: In women, higher parity has been associated with increased risk of diabetes later in life. It is unclear, however, whether this association is mainly due to biological effects of childbearing, or to socioeconomic and lifestyle factors associated with childrearing. We assessed the association between number of children and diabetes risk separately in women and men. METHODS: Between 2004 and 2008, the nationwide China Kadoorie Biobank recruited 0...
August 2016: Diabetologia
https://www.readbyqxmd.com/read/27087208/-status-of-prevalence-awareness-treatment-and-controll-on-hypertension-among-adults-in-10-regions-china
#17
Jie Guo, Canqing Yu, Jun Lyu, Yu Guo, Zheng Bian, Huiyan Zhou, Yunlong Tan, Pei Pei, Junshi Chen, Zhengming Chen, Liming Li
OBJECTIVE: To describe the status of prevalence, awareness, treatment, and control of hypertension among half a million adults in 10 regions under the China Kadoorie Biobank (CKB) cohort. METHODS: The baseline survey of CKB was performed in 10 areas across China during 2004-2008, included 512 891 adults aged from 30 to 79 years. Regional differences of prevalence, awareness, treatment and control of hypertension were compared after adjustment for age and/or sex...
April 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27053236/evaluation-of-type-2-diabetes-genetic-risk-variants-in-chinese-adults-findings-from-93-000-individuals-from-the-china-kadoorie-biobank
#18
Wei Gan, Robin G Walters, Michael V Holmes, Fiona Bragg, Iona Y Millwood, Karina Banasik, Yiping Chen, Huaidong Du, Andri Iona, Anubha Mahajan, Ling Yang, Zheng Bian, Yu Guo, Robert J Clarke, Liming Li, Mark I McCarthy, Zhengming Chen
AIMS/HYPOTHESIS: Genome-wide association studies (GWAS) have discovered many risk variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 diabetes predisposition are often based on highly selected case-control samples, and reliable estimates of population-level effect sizes are missing, especially in non-European populations. METHODS: The individual and cumulative effects of 59 established type 2 diabetes risk loci were measured in a population-based China Kadoorie Biobank (CKB) study of 93,000 Chinese adults, including >7,100 diabetes cases...
July 2016: Diabetologia
https://www.readbyqxmd.com/read/27050205/fresh-fruit-consumption-and-major-cardiovascular-disease-in-china
#19
Huaidong Du, Liming Li, Derrick Bennett, Yu Guo, Timothy J Key, Zheng Bian, Paul Sherliker, Haiyan Gao, Yiping Chen, Ling Yang, Junshi Chen, Shanqing Wang, Ranran Du, Hua Su, Rory Collins, Richard Peto, Zhengming Chen
BACKGROUND: In Western populations, a higher level of fruit consumption has been associated with a lower risk of cardiovascular disease, but little is known about such associations in China, where the consumption level is low and rates of stroke are high. METHODS: Between 2004 and 2008, we recruited 512,891 adults, 30 to 79 years of age, from 10 diverse localities in China. During 3.2 million person-years of follow-up, 5173 deaths from cardiovascular disease, 2551 incident major coronary events (fatal or nonfatal), 14,579 ischemic strokes, and 3523 intracerebral hemorrhages were recorded among the 451,665 participants who did not have a history of cardiovascular disease or antihypertensive treatments at baseline...
April 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26975032/the-burden-of-hypertension-and-associated-risk-for-cardiovascular-mortality-in-china
#20
Sarah Lewington, Ben Lacey, Robert Clarke, Yu Guo, Xiang Ling Kong, Ling Yang, Yiping Chen, Zheng Bian, Junshi Chen, Jinhuai Meng, Youping Xiong, Tianyou He, Zengchang Pang, Shuo Zhang, Rory Collins, Richard Peto, Liming Li, Zhengming Chen
IMPORTANCE: Hypertension is a leading cause of premature death in China, but limited evidence is available on the prevalence and management of hypertension and its effect on mortality from cardiovascular disease (CVD). OBJECTIVES: To examine the prevalence, diagnosis, treatment, and control of hypertension and to assess the CVD mortality attributable to hypertension in China. DESIGN, SETTING AND PARTICIPANTS: This prospective cohort study (China Kadoorie Biobank Study) recruited 500 223 adults, aged 35 to 74 years, from the general population in China...
April 2016: JAMA Internal Medicine
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