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https://www.readbyqxmd.com/read/29655987/overcoming-safety-challenges-in-co-therapy-extracorporeal-co-delivery-under-precise-feedback-control-of-systemic-carboxyhemoglobin-levels
#1
Jakob Wollborn, Cornelius Hermann, Ulrich Goebel, Benjamin Merget, Christian Wunder, Sven Maier, Thomas Schäfer, Dominik Heuler, Klaus Müller-Buschbaum, Hartmut Buerkle, Lorenz Meinel, Martin A Schick, Christoph Steiger
Carbon monoxide (CO) has demonstrated therapeutic potential in multiple inflammatory conditions including intensive care applications such as organ transplantation or sepsis. Approaches to translate these findings into future therapies, however, have been challenged by multiple hurdles including handling and toxicity issues associated with systemic CO delivery. Here, we describe a membrane-controlled Extracorporeal Carbon Monoxide Release System (ECCORS) for easy implementation into Extracorporeal Membrane Oxygenation (ECMO) setups, which are being used to treat cardiac and respiratory diseases in various intensive care applications...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29655387/specimens-slips-and-systems-daniel-solander-and-the-classification-of-nature-at-the-world-s-first-public-museum-1753-1768
#2
Edwin D Rose
The British Museum, based in Montague House, Bloomsbury, opened its doors on 15 January 1759, as the world's first state-owned public museum. The Museum's collection mostly originated from Sir Hans Sloane (1660-1753), whose vast holdings were purchased by Parliament shortly after his death. The largest component of this collection was objects of natural history, including a herbarium made up of 265 bound volumes, many of which were classified according to the late seventeenth-century system of John Ray (1627-1705)...
April 15, 2018: British Journal for the History of Science
https://www.readbyqxmd.com/read/29652562/serious-gaming-a-tool-to-educate-health-care-providers-about-domestic-violence
#3
Robin Mason, Linda Turner
Due to the adverse health effects, victims of domestic violence are frequently seen in the health care system. Yet, health care providers may lack the training to assist them. Online curricula can be an effective instructional tool. Our competency-based, serious video game, Responding to Domestic Violence in Clinical Settings, was designed to address health care providers' knowledge gaps through 17 modules, each a half hour in length. Nearly 9,000 participants completed at least one module; nursing students completed the most modules, approximately five hours of instruction...
April 13, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29652042/-motor-learning-of-the-post-stroke-patients-presenting-with-upper-limb-paresis-on-the-mechanotherapeutic-system
#4
A E Khizhnikova, A S Klochkov, A M Kotov-Smolensky, L A Chernikova, N A Suponeva, M A Piradov
BACKGROUND: the relevance of this study arises from the high prevalence of upper limb motor impairment and pathological synergy in the post-stroke patients; these conditions are very difficult to correct with the use of the traditional rehabilitation methods. A promising but insufficiently studied approaches are the virtual reality (VR) technology as well as its combination with other techniques. AIM: The objective of the present study was to evaluate the influence of the training making use of the mechanotherapeutic system on the motor function of the paretic hand...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29651752/on-the-limits-of-statistical-learning-intertrial-contextual-cueing-is-confined-to-temporally-close-contingencies
#5
Cyril Thomas, André Didierjean, François Maquestiaux, Annabelle Goujon
Since the seminal study by Chun and Jiang (Cognitive Psychology, 36, 28-71, 1998), a large body of research based on the contextual-cueing paradigm has shown that the cognitive system is capable of extracting statistical contingencies from visual environments. Most of these studies have focused on how individuals learn regularities found within an intratrial temporal window: A context predicts the target position within a given trial. However, Ono, Jiang, and Kawahara (Journal of Experimental Psychology, 31, 703-712, 2005) provided evidence of an intertrial implicit-learning effect when a distractor configuration in preceding trials N - 1 predicted the target location in trials N...
April 12, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29651365/mastication-evaluation-with-unsupervised-learning-using-an-inertial-sensor-based-system
#6
Caroline Vieira Lucena, Marcelo Lacerda, Rafael Caldas, Fernando Buarque De Lima Neto, Diego Rativa
There is a direct relationship between the prevalence of musculoskeletal disorders of the temporomandibular joint and orofacial disorders. A well-elaborated analysis of the jaw movements provides relevant information for healthcare professionals to conclude their diagnosis. Different approaches have been explored to track jaw movements such that the mastication analysis is getting less subjective; however, all methods are still highly subjective, and the quality of the assessments depends much on the experience of the health professional...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29651236/substrates-for-neuronal-cotransmission-with-neuropeptides-and-small-molecule-neurotransmitters-in-drosophila
#7
REVIEW
Dick R Nässel
It has been known for more than 40 years that individual neurons can produce more than one neurotransmitter and that neuropeptides often are colocalized with small molecule neurotransmitters (SMNs). Over the years much progress has been made in understanding the functional consequences of cotransmission in the nervous system of mammals. There are also some excellent invertebrate models that have revealed roles of coexpressed neuropeptides and SMNs in increasing complexity, flexibility, and dynamics in neuronal signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29650871/-a-discussion-of-involvement-of-pharmacists-in-home-medical-care-in-foreign-countries-and-international-comparison-of-medical-care-system
#8
Tokuko Okuda
In an aging society, the sustainability of the public medical system is the most important factor. I surveyed leading cases in Japan, as well as corresponding cases overseas. I also conducted interviews in Britain, North America, and Europe, and these indicated the current trends and issues. The UK has a universal insurance system and, facing a declining birthrate and an aging population, they have adopted a policy of immigration, which has various problems. However, the GP system is highly regarded by the OECD...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650810/-artificial-intelligence-in-drug-discovery
#9
Takeshi Fujiwara, Mayumi Kamada, Yasushi Okuno
According to the increase of data generated from analytical instruments, application of artificial intelligence(AI)technology in medical field is indispensable. In particular, practical application of AI technology is strongly required in "genomic medicine" and "genomic drug discovery" that conduct medical practice and novel drug development based on individual genomic information. In our laboratory, we have been developing a database to integrate genome data and clinical information obtained by clinical genome analysis and a computational support system for clinical interpretation of variants using AI...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650698/credit-assignment-in-a-motor-decision-making-task-is-influenced-by-agency-and-not-sensorimotor-prediction-errors
#10
Darius E Parvin, Samuel D McDougle, Jordan A Taylor, Richard B Ivry
Failures to obtain reward can occur from errors in action selection or action execution. Recently, we observed marked differences in choice behavior when the failure to obtain a reward was attributed to errors in action execution compared to errors in action selection (McDougle et al. , 2016). Specifically, participants appeared to solve this credit assignment problem by discounting outcomes in which the absence of reward was attributed to errors in action execution. Building on recent evidence indicating relatively direct communication between the cerebellum and basal ganglia, we hypothesized that cerebellar-dependent sensory-prediction errors (SPEs), a signal indicating execution failure, could attenuate value updating within a basal-ganglia dependent reinforcement learning system...
April 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29650319/psoriasis-skin-biopsy-image-segmentation-using-deep-convolutional-neural-network
#11
Anabik Pal, Utpal Garain, Aditi Chandra, Raghunath Chatterjee, Swapan Senapati
BACKGROUND AND OBJECTIVE: Development of machine assisted tools for automatic analysis of psoriasis skin biopsy image plays an important role in clinical assistance. Development of automatic approach for accurate segmentation of psoriasis skin biopsy image is the initial prerequisite for developing such system. However, the complex cellular structure, presence of imaging artifacts, uneven staining variation make the task challenging. This paper presents a pioneering attempt for automatic segmentation of psoriasis skin biopsy images...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29650303/generating-region-proposals-for-histopathological-whole-slide-image-retrieval
#12
Yibing Ma, Zhiguo Jiang, Haopeng Zhang, Fengying Xie, Yushan Zheng, Huaqiang Shi, Yu Zhao, Jun Shi
BACKGROUND AND OBJECTIVE: Content-based image retrieval is an effective method for histopathological image analysis. However, given a database of huge whole slide images (WSIs), acquiring appropriate region-of-interests (ROIs) for training is significant and difficult. Moreover, histopathological images can only be annotated by pathologists, resulting in the lack of labeling information. Therefore, it is an important and challenging task to generate ROIs from WSI and retrieve image with few labels...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29649152/study-on-interference-suppression-algorithms-for-electronic-noses-a-review
#13
REVIEW
Zhifang Liang, Fengchun Tian, Simon X Yang, Ci Zhang, Hao Sun, Tao Liu
Electronic noses (e-nose) are composed of an appropriate pattern recognition system and a gas sensor array with a certain degree of specificity and broad spectrum characteristics. The gas sensors have their own shortcomings of being highly sensitive to interferences which has an impact on the detection of target gases. When there are interferences, the performance of the e-nose will deteriorate. Therefore, it is urgent to study interference suppression techniques for e-noses. This paper summarizes the sources of interferences and reviews the advances made in recent years in interference suppression for e-noses...
April 12, 2018: Sensors
https://www.readbyqxmd.com/read/29648686/development-and-validation-of-a-novel-evidence-based-lupus-multivariable-outcome-score-for-clinical-trials
#14
Michal Abrahamowicz, John M Esdaile, Rosalind Ramsey-Goldman, Lee S Simon, Vibeke Strand, Peter E Lipsky
BACKGROUND: Trials of new SLE treatments are hampered by the lack of effective outcome measures. To address this, we developed a new Lupus Multivariable Lupus Outcome Score (LuMOS). METHOD: The LuMOS formula was developed by analyzing raw data of two pivotal trials: BLISS-52 and BLISS-76, the basis for approval of belimumab (Bel). Using data from BLISS-76 as the learning dataset, we optimized discrimination between outcomes for patients treated with 10mg/kg Bel versus placebo over the first 52 weeks of follow-up using multivariable logistic regression analyses...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29644604/groundwater-nitrate-pollution-and-climate-change-learnings-from-a-water-balance-based-analysis-of-several-aquifers-in-a-western-mediterranean-region-catalonia
#15
Josep Mas-Pla, Anna Menció
Climate change will affect the dynamics of the hydrogeological systems and their water resources quality; in particular nitrate, which is herein taken as a paradigmatic pollutant to illustrate the effects of climate change on groundwater quality. Based on climatic predictions of temperature and precipitation for the horizon of 2021 and 2050, as well as on land use distribution, water balances are recalculated for the hydrological basins of distinct aquifer systems in a western Mediterranean region as Catalonia (NE Spain) in order to determine the reduction of available water resources...
April 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29643760/a-comparison-of-low-complexity-real-time-feature-extraction-for-neuromorphic-speech-recognition
#16
Jyotibdha Acharya, Aakash Patil, Xiaoya Li, Yi Chen, Shih-Chii Liu, Arindam Basu
This paper presents a real-time, low-complexity neuromorphic speech recognition system using a spiking silicon cochlea, a feature extraction module and a population encoding method based Neural Engineering Framework (NEF)/Extreme Learning Machine (ELM) classifier IC. Several feature extraction methods with varying memory and computational complexity are presented along with their corresponding classification accuracies. On the N-TIDIGITS18 dataset, we show that a fixed bin size based feature extraction method that votes across both time and spike count features can achieve an accuracy of 95% in software similar to previously report methods that use fixed number of bins per sample while using ~3× less energy and ~25× less memory for feature extraction (~1...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29642656/socio-economic-disparities-and-difficulties-to-access-to-healthcare-services-among-canadian-children-with-neurodevelopmental-disorders-and-disabilities
#17
Sana Raouafi, Sofiane Achiche, Maxime Raison
Objectives: The aim of this study is to identify the association between levels of severity of nurodevelopmental disorders and disabilities (NDD/D) in children, their household socio-economic status (SES), and the frequency of visits to a healthcare provider; and (2) to examine how the severity of disability differs with these determinants among NDD/D subgroups, to make a social policy change and improve access to health care system. Methods: The data from the 2006 Participation and Activity Limitation Survey (PALS) on children (5-14y), collected by Statistics Canada, was analyzed (n= 7,072 and weighted n = 340,340)...
March 29, 2018: Epidemiology and Health
https://www.readbyqxmd.com/read/29642638/analysis-of-a-smartphone-based-architecture-with-multiple-mobility-sensors-for-fall-detection-with-supervised-learning
#18
José Antonio Santoyo-Ramón, Eduardo Casilari, José Manuel Cano-García
This paper describes a wearable Fall Detection System (FDS) based on a body-area network consisting of four nodes provided with inertial sensors and Bluetooth wireless interfaces. The signals captured by the nodes are sent to a smartphone which simultaneously acts as another sensing point. In contrast to many FDSs proposed by the literature (which only consider a single sensor), the multisensory nature of the prototype is utilized to investigate the impact of the number and the positions of the sensors on the effectiveness of the production of the fall detection decision...
April 10, 2018: Sensors
https://www.readbyqxmd.com/read/29629874/object-discrimination-using-electrotactile-feedback
#19
Tapas Jaywant Arakeri, Brady A Hasse, Andrew J Fuglevand
A variety of bioengineering systems are being developed to restore tactile sensations in individuals who have lost somatosensory feedback because of spinal cord injury, stroke, or amputation. These systems typically detect tactile force with sensors placed on an insensate hand (or prosthetic hand in the case of amputees) and deliver touch information by electrically or mechanically stimulating sensate skin above the site of injury. Successful object manipulation, however, also requires proprioceptive feedback representing the configuration and movements of the hand and digits...
April 9, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29629791/at-what-cost-examining-the-cost-effectiveness-of-a-universal-social-emotional-learning-program
#20
Leah J Hunter, James C DiPerna, Susan Crandall Hart, Max Crowley
Although implementation of universal social-emotional learning programs is becoming more common in schools, few studies have examined the cost-effectiveness of such programs. As such, the purpose of this article is two fold. First, we provide an overview of cost-effectiveness methods for school-based programs, and second, we share results of a cost-effectiveness analysis (CEA) of a universal social-emotional learning (SEL) program, the Social Skills Improvement System-Classwide Intervention Program (SSIS-CIP; Elliott & Gresham, 2007)...
March 2018: School Psychology Quarterly
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