keyword
MENU ▼
Read by QxMD icon Read
search

Advance in medicine

keyword
https://www.readbyqxmd.com/read/28945025/-dna-marker-assisted-selection-of-medicinal-plants-%C3%A2-breeding-research-of-disease-resistant-cultivars-of-panax-notoginseng
#1
Lin-Lin Dong, Zhong-Jian Chen, Yong Wang, Fu-Gang Wei, Lian-Juan Zhang, Jiang Xu, Guang-Fei Wei, Rui Wang, Juan Yang, Wei-Lin Liu, Xi-Wen Li, Yu-Qi Yu, Shi-Lin Chen
DNA marker-assisted selection of medicinal plants is based on the DNA polymorphism, selects the DNA sequences related to the phenotypes such as high yields, superior quality, stress-resistance and so on according to the technologies of molecular hybridization, polymerase chain reaction and high-throughput sequencing, and assists the breeding of new cultivars. This study bred the first disease-resistant cultivar of notoginseng "Miaoxiang Kangqi 1" using the technology of DNA marker-assisted selection of medicinal plants and systematic breeding...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945020/-a-phytochemical-and-pharmacological-advance-on-ilex-asprella
#2
REVIEW
Bing-Zhao Du, Xin-Yao Yang, Xiao Feng, Xu Yin, He-Xin-Ge Zhang, Feng Zhao, Zeng-Ping Gao, Peng-Fei Tu, Xing-Yun Chai
Ilex asprella is one of representative medicinal plants in South of the Five Ridges of China. The roots and rhizomes of I. asprella have the effects of clearing heat and detoxifying, stimulating salvia, and reducing thirst, which has been used to treat wind-heat cold, acute and chronic pharyngitis, and sore throat. Contemporary studies showed that I. asprella contains the major triterpenoids and glycosides, phenolic acids, and minor steroids. The extracts and compounds show activities of anti-inflammatory, antiviral, anti-tumor, and regulating lipid metabolism...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944552/an-av-rgd-integrin-inhibitor-toolbox-drug-discovery-insight-challenges-and-opportunities
#3
Richard Hatley, Simon Macdonald, Robert Slack, Joelle Le, Steve Ludbrook, Pauline Lukey
There is a requirement for efficacious and safe medicines to treat diseases with high unmet need. The resurgence in av RGD integrin inhibitor drug discovery is poised to contribute to this requirement. However, drug discovery in the av integrin space is notoriously difficult due to the receptors being structurally very similar as well as the polar zwitterionic nature of the pharmacophore. This review aims to guide drug discovery research in this field through an av inhibitor toolbox, consisting of small molecules and antibodies...
September 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28944321/effect-of-evacuation-and-displacement-on-the-association-between-flooding-and-mental-health-outcomes-a-cross-sectional-analysis-of-uk-survey-data
#4
Alice Munro, R Sari Kovats, G James Rubin, Thomas David Waite, Angie Bone, Ben Armstrong
BACKGROUND: Extensive flooding occurred during the winter of 2013-14 in England. Previous studies have shown that flooding affects mental health. Using data from the 2013-14 Public Health England National Study of Flooding and Health, we compared the prevalence of symptoms of depression, anxiety, and post-traumatic stress disorder between participants displaced by flooding and those flooded, but not displaced, 1 year after flooding. METHODS: In this multivariable ordinal regression analysis, we collected data from a cross-sectional survey collected 1 year after the flooding event from flood-affected postcodes in five counties in England...
July 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/28944295/towards-precision-medicine-in-alzheimer-s-disease-deciphering-genetic-data-to-establish-informative-biomarkers
#5
Ornit Chiba-Falek, Michael W Lutz
INTRODUCTION: Developing biomarker tools for identification of individuals at high-risk for late-onset Alzheimer's disease (LOAD) is important for prognosis and early treatment. This review focuses on genetic factors and their potential role for precision medicine in LOAD. AREAS COVERED: APOEe4 is the strongest genetic risk factor for non-Mendelian LOAD, and the APOE-linkage disequilibrium (LD) region has produced the most significant association signal in multi-center genome-wide-association-studies (GWAS)...
2017: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/28944288/the-wisdom-study-breaking-the-deadlock-in-the-breast-cancer-screening-debate
#6
REVIEW
Laura J Esserman
There are few medical issues that have generated as much controversy as screening for breast cancer. In science, controversy often stimulates innovation; however, the intensely divisive debate over mammographic screening has had the opposite effect and has stifled progress. The same two questions-whether it is better to screen annually or bi-annually, and whether women are best served by beginning screening at 40 or some later age-have been debated for 20 years, based on data generated three to four decades ago...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28944281/adenovirus-mediated-gene-delivery-potential-applications-for-gene-and-cell-based-therapies-in-the-new-era-of-personalized-medicine
#7
Cody S Lee, Elliot S Bishop, Ruyi Zhang, Xinyi Yu, Evan M Farina, Shujuan Yan, Chen Zhao, Zongyue Zheng, Yi Shu, Xingye Wu, Jiayan Lei, Yasha Li, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Sherwin Ho, Aravind Athiviraham, Michael J Lee, Jennifer Moriatis Wolf, Russell R Reid, Tong-Chuan He
With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases. It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies...
June 2017: Genes & Diseases
https://www.readbyqxmd.com/read/28943986/medical-and-pharmacy-students-attitudes-towards-physician-pharmacist-collaboration-in-kuwait
#8
Maram G Katoue, Abdelmoneim I Awad, Aishah Al-Jarallah, Ebaa Al-Ozairi, Terry L Schwinghammer
OBJECTIVE: To assess and compare the attitudes of medical and pharmacy students towards physician-pharmacist collaboration and explore their opinions about the barriers to collaborative practice in Kuwait. METHODS: A cross-sectional survey of pharmacy and medical students (n=467) was conducted in Faculties of Medicine and Pharmacy, Kuwait University. Data were collected via self-administered questionnaire from first-year pharmacy and medical students and students in the last two professional years of the pharmacy and medical programs...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28942908/integrating-function-directed-treatments-into-palliative-care
#9
REVIEW
Andrea L Cheville, Melissa Morrow, Sean Robinson Smith, Jeffrey R Basford
The growing acceptance of palliative care has created opportunities to increase the use of rehabilitation services among populations with advanced disease, particularly those with cancer. Broader delivery has been impeded by the lack of a shared definition for palliative rehabilitation and a mismatch between patient needs and established rehabilitation service delivery models. We propose the definition that, in the advanced cancer population, palliative rehabilitation is function-directed care delivered in partnership with other clinical disciplines and aligned with the values of patients who have serious and often incurable illnesses in contexts marked by intense and dynamic symptoms, psychological stress, and medical morbidity to realize potentially time-limited goals...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942886/who-treats-lung-cancer-results-from-a-global-survey
#10
Takefumi Komiya, Christine B Mackay, Prabhakar Chalise
BACKGROUND: In most Western nations, the medical oncologist plays a significant role in the administration of systemic therapy for lung cancer. In Japan however, treatment for lung cancer has historically been provided by pulmonologists and thoracic surgeons. A comparison of the management of advanced disease between Japan and other nations has not been described. METHODS: An online, self-administered, international survey was sent to 3907 active members of the American Society of Clinical Oncology...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28941606/new-developments-in-hypertrophic-cardiomyopathy
#11
REVIEW
Robert M Cooper, Claire E Raphael, Max Liebregts, Nandan S Anavekar, Josef Veselka
Hypertrophic cardiomyopathy is the leading cause of sudden death in young individuals and an important cause of heart failure at any age. In this review we discuss advances in investigation and management of this heterogenous disease. Improved cardiac imaging has allowed us to detail many of the structural abnormalities whereas the use of new techniques, predominantly in cardiac magnetic resonance imaging, has given us a greater insight in to tissue architecture, mechanism of contractile abnormalities, and function...
October 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28941341/-application-of-genome-engineering-in-medical-synthetic-biology
#12
Fangyuan Wang, Dehua Zhao, Lei Stanley Qi
Synthetic biology aims to establish a complete set of engineering principles, theories, and methods, via the rational design and assembly of basic biological parts, for the goal of effective implementation of complex biological systems with programmable functions. In recent years, with emerging novel classes of programmable genetic parts, in particular, the establishment and optimization of CRISPR and CRISPRi technology platforms, synthetic biology is entering a new era. This review summarizes recent advances on CRISPR genome editing and gene regulation technologies, their applications in constructing programmable biological parts, and their roles in building sophisticated gene circuits...
March 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28941317/concise-review-extracellular-vesicles-overcoming-limitations-of-cell-therapies-in-ischemic-stroke
#13
Thorsten R Doeppner, Mathias Bähr, Dirk M Hermann, Bernd Giebel
Despite recent advances in stroke therapy, current therapeutic concepts are still limited. Thus, additional therapeutic strategies are in order. In this sense, the transplantation of stem cells has appeared to be an attractive adjuvant tool to help boost the endogenous regenerative capacities of the brain. Although transplantation of stem cells is known to induce beneficial outcome in (preclinical) stroke research, grafted cells do not replace lost tissue directly. Rather, these transplanted cells like neural progenitor cells or mesenchymal stem cells act in an indirect manner, among which the secretion of extracellular vesicles (EVs) appears to be one key factor...
September 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28941046/pericytes-and-their-potential-in-regenerative-medicine-across-species
#14
REVIEW
C L Esteves, F X Donadeu
The discovery that pericytes are in vivo counterparts of Mesenchymal Stem/Stromal Cells (MSCs) has placed these perivascular cells in the research spotlight, bringing up hope for a well-characterized cell source for clinical applications, alternative to poorly defined, heterogeneous MSCs preparations currently in use. Native pericytes express typical MSC markers and, after isolation by fluorescence-activated cell sorting, display an MSC phenotype in culture. These features have been demonstrated in different species, including humans and horses, the main targets of regenerative treatments...
September 20, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28940345/crispr-becomes-clearer
#15
Andrew W Torrance
In this pivotal year for gene editing, the breakthrough molecular system CRISPR-Cas9 has advanced on three fronts. In under seven months, an influential scientific body-the National Academies of Sciences, Engineering, and Medicine the National Academies of Sciences, Engineering, and Medicine-cracked open the door to human germline gene editing, ownership of patents covering CRISPR-Cas9 came into much sharper focus as a result of a dispute between two parties, and experiments showing proof of concept of the most controversial of uses-altering germlines of humans-were revealed as having been successfully performed by a mainstream laboratory...
September 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28940141/iq%C3%A2-spect-technology-and-its-clinical-applications-using-multicenter-normal-databases
#16
Kenichi Nakajima, Koichi Okuda, Mitsuru Momose, Shinro Matsuo, Chisato Kondo, Masayoshi Sarai, Takayuki Shibutani, Masahisa Onoguchi, Takeshi Shimizu, A Hans Vija
IQ·SPECT (Siemens Medical Solutions) is a solution for high-sensitivity and short-time acquisition imaging of the heart for a variable angle general purpose gamma camera. It consists of a multi-focal collimator, a cardio-centric orbit and advanced iterative reconstruction, modeling the image formation physics accurately. The multi-focal collimator enables distance-dependent enlargement of the center region while avoiding truncation at the edges. With the specified configuration and a cardio-centric orbit it can obtain a fourfold sensitivity increase for the heart at the center of the scan orbit...
September 22, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28939679/next-generation-sequencing-in-the-clinical-setting-clarifies-patient-characteristics-and-potential-actionability
#17
Cheyennedra C Bieg-Bourne, Sherri Z Millis, David E Piccioni, Paul T Fanta, Michael E Goldberg, Juliann Chmielecki, Barbara A Parker, Razelle Kurzrock
Enhancements in clinical-grade next-generation sequencing (NGS) have fueled the advancement of precision medicine in the clinical oncology field. Here we survey the molecular profiles of 1,113 patients with diverse malignancies who successfully underwent clinical-grade NGS (236 to 404 genes) in an academic tertiary cancer center. Among the individual tumors examined, the majority showed at least one detectable alteration (97.2%). Amongst 2,045 molecular aberrations was involvement of 302 distinct genes. The most commonly altered genes were TP53 (47...
September 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28939377/nanoparticle-based-local-antimicrobial-drug-delivery
#18
Weiwei Gao, Yijie Chen, Yue Zhang, Qiangzhe Zhang, Liangfang Zhang
Despite the wide success of antibiotics in modern medicine, the treatment of bacterial infections still faces critical challenges, especially due to the rapid emergence of antibiotic resistance. As a result, local antimicrobial treatment aimed at enhancing drug concentration at the site of infection while avoiding systemic exposure is becoming increasingly attractive, as it may alleviate resistance development. Meanwhile, therapeutic nanoparticles, especially liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles, are gaining traction to improve the therapeutic efficacy with many applications specifically focused on local antimicrobial treatment...
September 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28939108/differential-response-to-doxorubicin-in-breast-cancer-subtypes-simulated-by-a-microfluidic-tumor-model
#19
Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han
Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of cancer. The ability to rapidly screen drugs and delivery systems within physiologically relevant environments is critically important; yet is currently limited due to lack of appropriate tumor models. To address this problem, we developed the Tumor-microenvironment-on-chip (T-MOC), a new microfluidic tumor model simulating the interstitial flow, plasma clearance, and transport of the drug within the tumor...
September 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28939026/metabolomics-coupled-with-similarity-analysis-advances-the-elucidation-of-the-cold-hot-properties-of-traditional-chinese-medicines
#20
Yan Jia, Zheng-Zheng Zhang, Yu-Hai Wei, Qin Xue-Mei, Zhen-Yu Li
It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine (TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance (NMR) based metabolomics approach coupled with similarity analysis...
August 2017: Chinese Journal of Natural Medicines
keyword
keyword
44446
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"