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https://www.readbyqxmd.com/read/29669224/evaluation-of-intussusception-after-monovalent-rotavirus-vaccination-in-africa
#1
Jacqueline E Tate, Jason M Mwenda, George Armah, Bhavin Jani, Richard Omore, Ayesheshem Ademe, Hilda Mujuru, Evans Mpabalwani, Bagrey Ngwira, Margaret M Cortese, Richard Mihigo, Hope Glover-Addy, Mwajabu Mbaga, Francis Osawa, Amezene Tadesse, Bothwell Mbuwayesango, Julia Simwaka, Nigel Cunliffe, Benjamin A Lopman, Goitom Weldegebriel, Daniel Ansong, David Msuya, Billy Ogwel, Thomas Karengera, Portia Manangazira, Bruce Bvulani, Catherine Yen, Felicitas R Zawaira, Clement T Narh, Lazaro Mboma, Peter Saula, Fasil Teshager, Halle Getachew, Rebecca M Moeti, Christabel Eweronu-Laryea, Umesh D Parashar
BACKGROUND: Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries. METHODS: Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29643120/ephrinb2-ephb4-signaling-regulates-non-sprouting-angiogenesis-by-vegf
#2
Elena Groppa, Sime Brkic, Andrea Uccelli, Galina Wirth, Petra Korpisalo-Pirinen, Maria Filippova, Boris Dasen, Veronica Sacchi, Manuele Giuseppe Muraro, Marianna Trani, Silvia Reginato, Roberto Gianni-Barrera, Seppo Ylä-Herttuala, Andrea Banfi
Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best-understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unknown. Here, we identify ephrinB2/EphB4 signaling as a key regulator of intussusceptive angiogenesis and its outcome under therapeutically relevant conditions. EphB4 signaling fine-tunes the degree of endothelial proliferation induced by specific VEGF doses during the initial stage of circumferential enlargement of vessels, thereby limiting their size and subsequently enabling successful splitting into normal capillary networks...
April 11, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29232349/management-of-intussusception-in-the-pediatric-emergency-department-risk-factors-for-recurrence
#3
Andrea Vo, Terry L Levin, Benjamin Taragin, Hnin Khine
BACKGROUND: The standard treatment for intussusception is air reduction enema (ARE) with inpatient observation for 24 to 48 hours to monitor for recurrence. More recent but limited observations suggest that patients who have undergone successful ARE can safely be discharged after 4 to 6 hours of observation. Our primary objective was to identify risk factors associated with early recurrence. Our secondary objectives included validating risk criteria from prior studies and identifying risk factors for ARE failures...
December 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29026515/intussusception-as-a-complication-of-bariatric-surgery-in-pregnant-patients-report-of-one-case-and-revision-of-the-literature
#4
Luis A Boccalatte, Juan Achaval Rodríguez, Axel Beskow, Demetrio Cavadas, Wright Fernando
Occlusive complications after a laparoscopic Roux-in Y gastric bypass (LRYGB), appear mainly as fibrous membranes of wounds, internal hernias or intussusception. Intussusception after a bariatric surgery occurs in 0.1-0.3% of the cases. We present a case of intussusception in a pregnant patient after a LRYGB.
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28957010/causes-of-normal-mortality-in-commercial-egg-laying-chickens
#5
Richard M Fulton
In a large population of animals, it is normal to have some die each day from causes not related to disease, which is often referred to as natural causes. In poultry production, this phenomenon is commonly referred to as daily mortality. In egg-producing chickens, many of the natural causes of death are associated with making an egg. The causes of normal mortality in commercial egg-laying chicken flocks have been described very little to date. A commercial chicken egg farm, housing approximately two million single-comb white leghorn chickens (Gallus gallus domesticus) in 16 egg-producing flocks, was visited on a monthly basis to monitor bird health, body conditioning, skeletal integrity, and causes of daily mortality in an attempt to provide early detection of health abnormalities...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28900777/an-exploration-of-genotype-phenotype-link-between-peutz-jeghers-syndrome-and-stk11-a-review
#6
REVIEW
Julian Daniell, John-Paul Plazzer, Anuradha Perera, Finlay Macrae
Peutz-Jeghers Syndrome (PJS) is an autosomal dominant hereditary polyposis syndrome. Clinical features include hamartomatous polyps, mucocutaneous pigmentation and an increased predisposition towards developing malignancy. Variants in STK11, a tumour suppressor gene, located on Chromosome 19, predispose to PJS. Peutz-Jeghers Syndrome is associated with increased rates of malignancy, particularly gastrointestinal. However, PJS is also associated with increased gynaecological, testicular and thyroid papillary malignancy...
September 12, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28709556/intussusception-among-children-less-than-2years-of-age-findings-from-pre-vaccine-introduction-surveillance-in-pakistan
#7
Mohammad Tahir Yousafzai, Rozina Thobani, Saqib Hamid Qazi, Nasir Saddal, Catherine Yen, Negar Aliabadi, Syed Asad Ali
BACKGROUND: Rotavirus vaccination introduction in routine immunization is under consideration in Pakistan. Data on the baseline epidemiology of intussusception will inform surveillance strategies for intussusception after rotavirus vaccine introduction in Pakistan. We describe the epidemiology of intussusception-associated hospitalizations among children <2years of age in Karachi, Pakistan. METHODS: We conducted a retrospective chart review for July 01, 2012 through June 30, 2015 at the National Institute of Child Health (NICH) and Aga Khan University Hospital (AKUH) Karachi...
July 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28674947/rectal-axis-and-enterocele-on-proctogram-may-predict-laparoscopic-ventral-mesh-rectopexy-outcomes-for-rectal-intussusception
#8
F Ris, K J Gorissen, J Ragg, M P Gosselink, N C Buchs, R Hompes, C Cunningham, O Jones, A Slater, I Lindsey
BACKGROUND: Laparoscopic ventral mesh rectopexy (LVMR) has become a well-established treatment for symptomatic high-grade internal rectal prolapse. The aim of this study was to identify proctographic criteria predictive of a successful outcome. METHODS: One hundred and twenty consecutive patients were evaluated from a prospectively maintained pelvic floor database. Pre- and post-operative functional results were assessed with the Wexner constipation score (WCS) and Fecal Incontinence Severity Index (FISI)...
August 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28649718/anal-sphincters-evaluation-by-endoanal-ultrasound-in-obstructed-defecation
#9
Andreia Albuquerque, Guilherme Macedo
OBJECTIVES: To evaluate anal sphincter abnormalities detected by endoanal ultrasound in obstructed defecation due to rectocele and rectal intussusception. METHODS: The retrospective analysis includes 45 patients with obstructed defecation syndrome due to rectocele and/or rectal intussusception with or without fecal incontinence, and submitted to endoanal ultrasound. RESULTS: Ninety-three percent (n = 42) were women (mean age of 63 ± 12 years), and 47% (n = 21) of the patients had fecal incontinence...
June 26, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28648544/risk-of-intussusception-following-rotavirus-vaccination-an-evidence-based-meta-analysis-of-cohort-and-case-control-studies
#10
Priya Kassim, Guy D Eslick
BACKGROUND: International post-licensure studies on rotavirus vaccines have identified an increased risk of intussusception in infants after administration. The first developed rotavirus vaccine (Rotashield (RRV-TV)) was suspended post-licensure in 1999 after an association with intussusception was found. The currently available second-generation rotavirus vaccines (Rotateq (RV5) and Rotarix (RV1)), are recommended as a routine vaccine by the World Health Organisation (WHO). Post-licensure studies of these vaccines have shown a smaller but temporal increased risk for developing intussusception...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28588977/determinants-of-morbidity-and-mortality-following-emergency-abdominal-surgery-in-children-in-low-income-and-middle-income-countries
#11
(no author information available yet)
BACKGROUND: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally. METHODS: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014...
2016: BMJ Global Health
https://www.readbyqxmd.com/read/28567798/management-for-intussusception-in-children
#12
REVIEW
Steven Gluckman, Jonathan Karpelowsky, Angela C Webster, Richard G McGee
BACKGROUND: Intussusception is a common abdominal emergency in children with significant morbidity. Prompt diagnosis and management reduces associated risks and the need for surgical intervention. Despite widespread agreement on the use of contrast enema as opposed to surgery for initial management in most cases, debate persists on the appropriate contrast medium, imaging modality, pharmacological adjuvant, and protocol for delayed repeat enema, and on the best approach for surgical management for intussusception in children...
June 1, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28419712/comparison-of-safety-and-efficacy-of-image-guided-enema-reduction-techniques-for-paediatric-intussusception-a-review-of-the-literature
#13
REVIEW
Renny Chew, Michael Ditchfield, Eldho Paul, Stacy K Goergen
There is variable international practice regarding the technique used for image-guided enema reduction in paediatric intussusception. A recent meta-analysis found pneumatic reduction to be more effective than hydrostatic techniques. Clinical practice variation may impact on perforation rates, ionizing radiation exposure and requirement for surgery. The aim of this study was to review the literature regarding the efficacy and safety of fluoroscopically guided pneumatic reduction (FGPR) compared to ultrasound (US) guided intussusception reduction (USGIR) techniques for paediatric intussusception treatment...
December 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28316328/reoperation-after-cyst-excision-with-hepaticojejunostomy-for-choledochal-cysts-our-experience-in-18-cases
#14
Qingfeng Sheng, Zhibao Lv, Weijue Xu, Xianmin Xiao, Jiangbin Liu, Yibo Wu
BACKGROUND Complete cyst excision with biliary reconstruction is the treatment of choice for choledochal cyst (CC). The aim of this article is to review our experience in patients who underwent reoperation between January 1995 and December 2014. MATERIAL AND METHODS The records of 18 patients (female/male, 15/3) were retrospectively analyzed including age, sex, cyst type, initial procedure, lab and imaging findings, indications for reoperation, intraoperative findings, and results of reoperation. The median follow-up period was 6 years...
March 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27599704/rectal-prolapse-traumatizes-rectal-neuromuscular-microstructure-explaining-persistent-rectal-dysfunction
#15
Matthias Kraemer, Werner Paulus, David Kara, Saskia Mankewitz, Stephanie Rozsnoki
PURPOSE: Internal rectal prolapse is common and correlates with age. It causes a plug-like physical obstruction and is a major cause of defecation disorder. The progressive distortion of the prolapsing rectum likely causes secondary defects in the rectal wall, which may exacerbate rectal dysfunction. We undertook a prospective observational study to detect and quantify the neurologic and histopathologic changes in the rectal wall. METHODS: We examined dorsal and ventral rectal wall specimens from consecutive patients with internal rectal prolapse undergoing stapled transanal rectal resection (STARR)...
December 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27561369/small-bowel-obstruction-in-the-virgin-abdomen-time-to-challenge-surgical-dogma-with-evidence
#16
Yvonne Ying-Ru Ng, James Chi-Yong Ngu, Andrew Siang-Yih Wong
BACKGROUND: Although adhesions account for more than 70% of small bowel obstruction (SBO), they are thought to be less likely aetiologies in patients without previous abdominal surgery. Expedient surgery has historically been advocated as prudent management in these patients. Emerging evidence appears to challenge such a dogmatic approach. METHODS: A retrospective analysis was performed in all SBO patients with a virgin abdomen admitted between January 2012 and August 2014...
January 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27554828/acute-small-bowel-obstruction-due-to-a-large-intraluminal-blood-clot-after-laparoscopic-roux-en-y-gastric-bypass
#17
Jessica Green, Tomoko Ikuine, Shoshana Hacker, Hernan Urrego, Karleena Tuggle
Small bowel obstructions (SBOs) are a known perioperative complication of laparoscopic Roux-en-Y gastric bypass and common etiologies include internal hernia, port site hernia, jejunojejunostomy stricture, ileus and adhesions. Less commonly, SBO can be caused by superior mesenteric artery syndrome, intussusception and intraluminal blood clot. We present a case of SBO caused by intraluminal blood clot from jejunojejunostomy staple line bleeding in a patient with a normal coagulation profile. Computed tomography was used to elucidate the cause of perioperative SBO, and diagnostic laparoscopy was used to both diagnose and treat the complication...
August 23, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27370308/evaluating-the-surgeons-perception-of-difficulties-of-two-techniques-to-perform-starr-for-obstructed-defecation-syndrome-a-multicenter-randomized-trial
#18
RANDOMIZED CONTROLLED TRIAL
Adolfo Renzi, Antonio Brillantino, Giandomenico Di Sarno, Francesco D'Aniello, Giuseppe Ferulano, Armando Falato
BACKGROUND: After initial enthusiasm in the use of a dedicated curved stapler (CCS-30 Contour Transtar) to perform stapled transanal rectal resection (STARR) for obstructed defecation syndrome (ODS), difficulties have emerged in this surgical technique. OBJECTIVE: First, to compare surgeons' perception of difficulties of STARR performed with only Transtar versus STARR performed with the combined use of linear staplers and Transtar to cure ODS associated with large internal prolapse and rectocele; second, to compare the postoperative incidence of the urge to defecate between the 2 STARR procedures...
December 2016: Surgical Innovation
https://www.readbyqxmd.com/read/27215528/-efficacy-observation-of-partial-stapled-transanal-rectal-resection-combined-with-bresler-procedure-in-the-treatment-of-rectocele-and-internal-rectal-intussusception
#19
RANDOMIZED CONTROLLED TRIAL
Zhiyong Liu, Guangen Yang, Qun Deng, Qingyan Yang
OBJECTIVE: To evaluate the efficacy of partial stapled transanal rectal resection (part-STARR) combined with Bresler procedure in the treatment of obstructed defecation syndrome (ODS) associated with rectocele and internal rectal intussusception(IRI), and compare with STARR. METHODS: A randomized controlled study from January 2013 to December 2014 was undertaken. Sixty female patients with ODS caused by rectocele and IRI were prospectively enrolled and randomly divided into trial group (29 cases) receiving part-STARR combined with Bresler procedure, and control group (31 cases) undergoing STARR only...
May 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27061976/bowel-obstruction-without-history-of-laparotomy-clinical-analysis-of-70-patients
#20
Koichiro Yoshimaru, Yoshiaki Kinoshita, Toshiharu Matsuura, Genshiro Esumi, Momoko Wada, Yoshiaki Takahashi, Yusuke Yanagi, Makoto Hayashida, Satoshi Ieiri, Tomoaki Taguchi
BACKGROUND: Determining the cause of bowel obstruction without a history of laparotomy (BO without HL) is difficult and can result in delay of treatment and development of a potentially life-threatening situation. We herein investigated the clinical characteristics of pediatric patients who underwent laparotomy due to BO without HL. METHODS: All surgical pediatric patients aged <16 age who were diagnosed with BO without HL between January 2004 and September 2014 were included...
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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