keyword
MENU ▼
Read by QxMD icon Read
search

Hiv co-infection

keyword
https://www.readbyqxmd.com/read/28212629/cardiometabolic-risk-in-a-population-of-older-adults-with-multiple-co-morbidities-in-rural-south-africa-the-haalsi-health-and-aging-in-africa-longitudinal-studies-of-indepth-communities-study
#1
Thomas A Gaziano, Shafika Abrahams-Gessel, F Xavier Gomez-Olive, Alisha Wade, Nigel J Crowther, Sartaj Alam, Jennifer Manne-Goehler, Chodziwadziwa W Kabudula, Ryan Wagner, Julia Rohr, Livia Montana, Kathleen Kahn, Till W Bärnighausen, Lisa F Berkman, Stephen Tollman
BACKGROUND: A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28212619/brain-and-liver-pathology-amyloid-deposition-and-interferon-responses-among-older-hiv-positive-patients-in-the-late-haart-era
#2
Isaac H Solomon, Umberto De Girolami, Sukrutha Chettimada, Vikas Misra, Elyse J Singer, Dana Gabuzda
BACKGROUND: HIV+ patients on highly active antiretroviral therapy (HAART) with suppressed viral loads have a low incidence of HIV-associated dementia, but increased prevalence of milder forms of HIV-associated neurocognitive disorders (HAND). These milder forms of HAND are often associated with minimal histological abnormalities, and their pathophysiology is unclear. Comorbidities, altered amyloid metabolism, accelerated brain aging, and activated interferon responses are suspected to play a role in HAND pathogenesis in HAART-treated persons...
February 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28210943/faces-of-frailty-in-aging-with-hiv-infection
#3
REVIEW
Marion Thurn, Deborah R Gustafson
PURPOSE OF THE REVIEW: The number of adults who are aging successfully and have HIV infection is increasing. More effective antiretroviral therapy (ART) regimens are preventing individuals infected with HIV from reaching end stages of the HIV infection and developing AIDS (acquired immunodeficiency syndrome). However, even at lower viral loads, chronic HIV infection appears to have consequences on aging processes, including the development of frailty. RECENT FINDINGS: Frailty is a term used to describe vulnerability in aging...
February 16, 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/28202751/superiority-in-rhesus-macaques-of-targeting-hiv-1-env-gp140-to-cd40-versus-lox-1-in-combination-with-replication-competent-nyvac-kc-for-induction-of-env-specific-antibody-and-t-cell-responses
#4
Gerard Zurawski, Xiaoying Shen, Sandra Zurawski, Georgia D Tomaras, David C Montefiori, Mario Roederer, Guido Ferrari, Christine Lacabaratz, Peter Klucar, Zhiqing Wang, Kathryn E Foulds, Shing-Fen Kao, Xuesong Yu, Alicia Sato, Nicole L Yates, Celia LaBranche, Sherry Stanfield-Oakley, Karen Kibler, Bertram Jacobs, Andres Salazar, Steve Self, Jimmy Fulp, Raphael Gottardo, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Giuseppe Pantaleo, Yves Levy
We compared the HIV-1-specific immune responses generated by targeting HIV-1 envelope protein (Env gp140) to either CD40 or LOX-1, two endocytic receptors on dendritic cells (DCs), in Rhesus macaques primed with a poxvirus vector (NYVAC-KC) expressing Env gp140. The DC-targeting vaccines, humanized recombinant monoclonal antibodies fused to Env gp140, were administered as a boost with poly ICLC adjuvant either alone or co-administered with the NYVAC-KC vector. All the DC-targeting vaccine administrations with poly ICLC increased the low-level serum anti-Env IgG responses elicited by NYVAC-KC priming significantly more (up to P =0...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28199517/real-world-effectiveness-of-daa-therapies-in-hiv-hcv-co-infection-996-veterans-can-t-be-wrong
#5
Mary Jane Burton, Susanna Naggie
No abstract text is available yet for this article.
February 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28199495/risk-factors-for-hepatitis-c-virus-reinfection-after-sustained-virologic-response-in-patients-co-infected-with-hiv
#6
Jim Young, Carmine Rossi, John Gill, Sharon Walmsley, Curtis Cooper, Joseph Cox, Valerie Martel-Laferriere, Brian Conway, Neora Pick, Marie-Louise Vachon, Marina B Klein
No abstract text is available yet for this article.
February 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28198792/child-growth-according-to-maternal-and-child-hiv-status-in-zimbabwe
#7
Adetayo O Omoni, Robert Ntozini, Ceri Evans, Andrew J Prendergast, Lawrence H Moulton, Parul S Christian, Jean H Humphrey
BACKGROUND: Growth failure is common among HIV-infected infants, but there are limited data on the effects of HIV exposure or timing of HIV acquisition on growth. METHODS: 14110 infants were enrolled in the ZVITAMBO trial in Zimbabwe before the availability of antiretroviral therapy (ART) or co-trimoxazole. Anthropometric measurements were taken from birth through 12-24 months of age. Growth outcomes were compared between 5 groups of children: HIV-infected in utero (IU), intrapartum (IP) or postnatally (PN); HIV-exposed uninfected (HEU); and HIV-unexposed...
February 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28198712/changes-in-levels-of-inflammation-following-antiretroviral-treatment-during-early-hiv-infection-in-actg-a5217
#8
Bernard J Macatangay, Ming Yang, Xin Sun, Jessica Morton, Victor DE Gruttola, Susan Little, Christine Hogan, Charles R Rinaldo
BACKGROUND: We evaluated the changes in the levels of soluble biomarkers of inflammation and coagulation and T cell activation among participants of ACTG A5217 who were started on antiretroviral therapy (ART) within the first 6 months of HIV infection. METHODS: Cryopreserved specimens were obtained pre-ART (Week 0), at time of virologic suppression (Week 36), and at 36 weeks after treatment interruption (Week 72). Levels of D-dimer, C-reactive protein (CRP), and soluble CD14 (sCD14) were measured in plasma, while T cell activation levels defined as the frequencies of CD4 and CD8 T cells co-expressing HLA-DR and CD38, were measured in peripheral blood mononuclear cells...
February 14, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28196510/partial-hiv-c2v3-envelope-sequence-analysis-reveals-association-of-coreceptor-tropism-envelope-glycosylation-and-viral-genotypic-variability-among-kenyan-patients-on-haart
#9
Rose C Kitawi, Carol W Hunja, Rashid Aman, Bernhards R Ogutu, Anne W T Muigai, Gilbert O Kokwaro, Washingtone Ochieng
BACKGROUND: HIV-1 is highly variable genetically and at protein level, a property it uses to subvert antiviral immunity and treatment. The aim of this study was to assess if HIV subtype differences were associated with variations in glycosylation patterns and co-receptor tropism among HAART patients experiencing different virologic treatment outcomes. METHODS: A total of 118 HIV env C2V3 sequence isolates generated previously from 59 Kenyan patients receiving highly active antiretroviral therapy (HAART) were examined for tropism and glycosylation patterns...
February 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28195558/elevated-pre-treatment-il-18-level-is-associated-with-hbeag-seroconversion-in-hiv-hbv-coinfection
#10
Yijia Li, Jing Xie, Huanling Wang, Yang Han, Nidan Wang, Chloe L Thio, Taisheng Li
BACKGROUND: In hepatitis B virus (HBV) infected patients, hepatitis B e antigen (HBeAg) seroconversion is associated with better outcomes. Interleukin-18 (IL-18) controls hepatitis B replication in a mouse model. However, its role in treatment response in HIV/HBV co-infected patients is unknown. METHODS: We enrolled 35 treatment-naïve, HBeAg positive, HIV/HBV co-infected patients. HBV DNA, HIV RNA, CD4 cell count, HBV surface antigen (HBsAg) quantification (qHBsAg), HBeAg quantification (qHBeAg) and IL-18 levels were measured prior to, at 24 and 48 weeks of HBV-active combination antiretroviral therapy (cART)...
February 14, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28193650/interaction-of-rifampicin-and-darunavir-ritonavir-or-darunavir-cobicistat-in-vitro
#11
Owain Roberts, Saye Khoo, Andrew Owen, Marco Siccardi
Treatment of HIV patients co-infected with tuberculosis (TB) is challenging due to drug-drug interactions (DDIs) between antiretrovirals (ARVs) and anti-TB drugs. The aim of this study was to quantify the effects of cobicistat (COBI), or ritonavir (RTV), in modulating DDIs between darunavir (DRV) and rifampicin (RIF) in a human hepatocyte-based in vitro model. Human primary hepatocyte cultures were incubated with RIF alone, or in combination with either COBI or RTV for three days, followed by co-incubation with DRV for one hour...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28193202/association-of-high-serum-vitamin-d-concentrations-with-active-pulmonary-tb-in-an-hiv-co-endemic-setting-harare-zimbabwe
#12
Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Duri, Kudzie Mateveke-Dangaiso, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma, Witmore Bayayi Mujaji
BACKGROUND: There is paucity data on the association of vitamin D deficiency (VDD) and active tuberculosis (TB) in southern Africa where the human immunodeficiency virus (HIV) is co-endemic. We examined the association of serum vitamin D concentrations with active pulmonary tuberculosis (PTB) in HIV-infected (n = 284) and uninfected (n = 267) Black Zimbabweans, in Harare, Zimbabwe. METHODS: We conducted a cross-sectional study of 551 participants comprising 145 HIV(+)/PTB (+), 139 HIV(+)/PTB(-), 134 HIV(-)/PTB(+) and 133 HIV(-)/PTB(-)...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28193199/a-population-based-study-of-chronic-hepatitis-c-in-immigrants-and-non-immigrants-in-quebec-canada
#13
Christina Greenaway, Laurent Azoulay, Robert Allard, Joseph Cox, Viet Anh Tran, Claire Nour Abou Chakra, Russ Steele, Marina Klein
BACKGROUND: Immigrants originating from intermediate and high HCV prevalence countries may be at increased risk of exposure to hepatitis C infection (HCV) in their countries of origin, however they are not routinely screened after arrival in most low HCV prevalence host countries. We aimed to describe the epidemiology of HCV in immigrants compared to the Canadian born population. METHODS: Using the reportable infectious disease database linked to the landed immigration database and several provincial administrative databases, we assembled a cohort of all reported cases of HCV in Quebec, Canada (1998-2008)...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28192455/suicide-risk-in-a-representative-sample-of-people-receiving-hiv-care-time-to-target-most-at-risk-populations-anrs-vespa2-french-national-survey
#14
Maria Patrizia Carrieri, Fabienne Marcellin, Lisa Fressard, Marie Préau, Luis Sagaon-Teyssier, Marie Suzan-Monti, Valérie Guagliardo, Marion Mora, Perrine Roux, Rosemary Dray-Spira, Bruno Spire
BACKGROUND: Suicide risk is high among people living with HIV (PLHIV). This study aimed to identify major correlates of suicide risk in a representative sample of PLHIV in France, in order to help target individuals who would benefit from suicide risk screening and psychiatric care. METHODS: The ANRS VESPA2 cross-sectional survey (April 2011-January 2012) collected socio-demographic, medical and behavioral data from 3,022 PLHIV recruited in 73 French HIV hospital departments...
2017: PloS One
https://www.readbyqxmd.com/read/28192453/refining-criteria-for-selecting-candidates-for-a-safe-lopinavir-ritonavir-or-darunavir-ritonavir-monotherapy-in-hiv-infected-virologically-suppressed-patients
#15
Nicola Gianotti, Alessandro Cozzi-Lepri, Andrea Antinori, Antonella Castagna, Andrea De Luca, Benedetto Maurizio Celesia, Massimo Galli, Cristina Mussini, Carmela Pinnetti, Vincenzo Spagnuolo, Antonella d'Arminio Monforte, Francesca Ceccherini-Silberstein, Massimo Andreoni
OBJECTIVE: The primary objective of this study was to estimate the incidence of treatment failure (TF) to protease inhibitor monotherapies (PI/r-MT) with lopinavir/ritonavir (LPV/r) or darunavir/ritonavir (DRV/r). DESIGN: A multicenter cohort of HIV-infected patients with viral load (VL) ≤50 copies/mL, who underwent a switch from any triple combination therapy to PI/r-MT with either LPV/r or DRV/r. METHODS: VL was assessed in each center according to local procedures...
2017: PloS One
https://www.readbyqxmd.com/read/28185538/synthesis-and-biological-evaluation-of-hybrid-1-5-and-2-5-disubstituted-indoles-as-potentially-new-antitubercular-agents
#16
Ana Soares, Mónica S Estevão, M Manuel B Marques, Vasily Kovalishyn, Diogo A R S Latino, João Aires-de-Sousa, Jorge Ramos, Miguel Viveiros, Filomena Martins
BACKGROUND: Tuberculosis (TB) is the second leading cause of mortality worldwide being a highly contagious and insidious illness caused by Mycobacterium tuberculosis, Mtb. Additionally, the emergence of multidrug-resistant and extensively drug-resistant strains of Mtb, together with significant levels of co-infection with HIV and TB (HIV/TB) makes the search for new antitubercular drugs urgent and challenging. METHODS: This work was based on the hypothesis that an active compound could be obtained if substituents present in some other active compounds were attached on a core of an important structure, in this case the indole scaffold, thus generating a hybrid compound...
February 9, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28184306/effect-of-malaria-infection-on-hematological-profiles-of-people-living-with-human-immunodeficiency-virus-in-gambella-southwest-ethiopia
#17
Tsion Sahle, Tilahun Yemane, Lealem Gedefaw
BACKGROUND: Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leucopenia are the common complications in malaria and HIV co-infected individuals. The aim of this study was to determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia. OBJECTIVE: To determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28182705/low-implementation-of-xpert-mtb-rif-among-hiv-tb-co-infected-adults-in-the-international-epidemiologic-databases-to-evaluate-aids-iedea-program
#18
Kate Clouse, Meridith Blevins, Mary Lou Lindegren, Marcel Yotebieng, Dung Thi Nguyen, Alfred Omondi, Denna Michael, Djimon Marcel Zannou, Gabriela Carriquiry, April Pettit
OBJECTIVE: Xpert MTB/RIF is recommended by the World Health Organization (WHO) as the initial tuberculosis (TB) diagnostic test in individuals suspected of HIV-associated TB. We sought to evaluate field implementation of Xpert among a cohort of HIV/TB co-infected individuals, including availability, utilization and outcomes. DESIGN: Observational cohort study (patient-level data) and cross-sectional study (site-level Xpert availability data). METHODS: Data were collected at 30 participating International epidemiologic Databases to Evaluate AIDS (IeDEA) sites in 18 countries from January 2012-January 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28182619/contribution-of-common-infections-to-cardiovascular-risk-in-hiv-positive-individuals
#19
Victoria Berquist, Jennifer F Hoy, Janine M Trevillyan
HIV-positive individuals are at increased risk for cardiovascular disease due to complex interactions between the increased incidence of traditional cardiovascular risk factors and HIV and antiretroviral-associated inflammation and dyslipidemia. Increasing evidence suggests that a number of important co-pathogens, including cytomegalovirus, hepatitis C virus, and periodontal disease, are likely to also be contributing. Mechanisms such as molecular mimicry and modification of lipids play a role; however, induction of systemic inflammation is the likely key pathogenic link by which this occurs...
February 9, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28182614/similar-immunological-profiles-between-nonprogressing-hiv-infection-in-children-and-nonpathogenic-siv-infection
#20
Eva Poveda, Enrique Martin-Gayo
In the absence of antirretroviral therapy (ART), HIV infection leads to progression to AIDS in most infected individuals. However, there is a small group of HIV-infected patients capable of spontaneously controlling HIV infection, known as the elite controllers (less than 1% of total infected population). These patients maintain undetectable levels of HIV replication, in part, due to a continuously effective HIV specific T cell response. Moreover, in HIV-infected patients with suppressed viremia under ART, a chronic activation of the immune system persist, which can be related to a poor clinical outcome including death, development of co-morbidities, AIDS and non-AIDS defining events...
January 2017: AIDS Reviews
keyword
keyword
44443
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"