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https://www.readbyqxmd.com/read/28813974/a-cosmetic-prosthetic-digit-with-bioinspired-embedded-touch-feedback
#1
Diego Barone, Marco D'Alonzo, Marco Controzzi, Francesco Clemente, Christian Cipriani
Partial hand amputation is the most frequent amputation level worldwide, accounting for approximately 90% of all upper limb amputations. Passive cosmetic prostheses represent one of the possible choices for its treatment, probably the most affordable one. However, these devices restore very limited motor function and subtle sensory feedback. The latter is an important component for restoring the body schema. In this work we present a simple yet potentially effective and low cost cosmetic digital prosthesis that embeds touch feedback; we dubbed this DESC-finger...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813650/we-can-still-be-friends-ifn-%C3%AE-breaks-up-macrophage-enhancers
#2
Boris Novakovic, Cheng Wang, Colin Logie
Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select active enhancers by interfering with enhancer-binding transcription factor MAF.
August 15, 2017: Immunity
https://www.readbyqxmd.com/read/28813600/discovery-of-enhanced-magnetoelectric-coupling-through-electric-field-control-of-two-magnon-scattering-within-distorted-nanostructures
#3
Xu Xue, Ziyao Zhou, Guohua Dong, Mengmeng Feng, Yijun Zhang, Shishun Zhao, Zhongqiang Hu, Wei Ren, Zuo-Guang Ye, Yaohua Liu, Ming Liu
Electric field control of dynamic spin interactions is promising to break through the limitation of magnetostatic interaction based magnetoelectric (ME) effect. In this work, electric field control of two-magnon scattering (TMS) effect excited by in-plane lattice rotation has been demonstrated in La0.7Sr0.3MnO3 (LSMO)/Pb(Mn2/3Nb1/3)-PbTiO3 (PMN-PT) (011) multiferroic heterostructure. Compared with the conventional strain-mediated ME effect, a giant enhancement of ME effect up to 950% at the TMS critical angle is precisely determined by angular resolution of the ferromagnetic resonance (FMR) measurement...
August 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28813565/selectivity-hyperselectivity-and-the-tuning-of-v1-neurons
#4
Kedarnath P Vilankar, David J Field
In this article, we explore two forms of selectivity in sensory neurons. The first we call classic selectivity, referring to the stimulus that optimally stimulates a neuron. If a neuron is linear, then this stimulus can be determined by measuring the response to an orthonormal basis set (the receptive field). The second type of selectivity we call hyperselectivity; it is either implicitly or explicitly a component of several models including sparse coding, gain control, and some linear-nonlinear models. Hyperselectivity is unrelated to the stimulus that maximizes the response...
August 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28813201/applying-movement-ecology-to-marine-animals-with-complex-life-cycles
#5
Richard M Allen, Anna Metaxas, Paul V R Snelgrove
Marine animals with complex life cycles may move passively or actively for fertilization, dispersal, predator avoidance, resource acquisition, and migration, and over scales from micrometers to thousands of kilometers. This diversity has catalyzed idiosyncratic and unfocused research, creating unsound paradigms regarding the role of movement in ecology and evolution. The emerging movement ecology paradigm offers a framework to consolidate movement research independent of taxon, life-history stage, scale, or discipline...
August 16, 2017: Annual Review of Marine Science
https://www.readbyqxmd.com/read/28813022/impact-of-orientation-on-the-vitamin-d-weighted-exposure-of-a-human-in-an-urban-environment
#6
Michael Schrempf, Nadine Thuns, Kezia Lange, Gunther Seckmeyer
The vitamin D₃-weighted UV exposure of a human with vertical posture was calculated for urban locations to investigate the impact of orientation and obstructions on the exposure. Human exposure was calculated by using the 3D geometry of a human and integrating the radiance, i.e., the radiant energy from the direct solar beam and the diffuse sky radiation from different incident and azimuth angles. Obstructions of the sky are derived from hemispherical images, which are recorded by a digital camera with a fisheye lens...
August 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28812792/a-case-for-open-network-health-systems-systems-as-networks-in-public-mental-health
#7
Michael Grant Rhodes, Marten W de Vries
Increases in incidents involving so-called confused persons have brought attention to the potential costs of recent changes to public mental health (PMH) services in the Netherlands. Decentralized under the (Community) Participation Act (2014), local governments must find resources to compensate for reduced central funding to such services or "innovate." But innovation, even when pressure for change is intense, is difficult. This perspective paper describes experience during and after an investigation into a particularly violent incident and murder...
January 8, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812626/dispersal-governs-the-reorganization-of-ecological-networks-under-environmental-change
#8
Patrick L Thompson, Andrew Gonzalez
Ecological networks, such as food webs, mutualist webs and host-parasite webs, are reorganizing as species abundances and spatial distributions shift in response to environmental change. Current theoretical expectations for how this reorganization will occur are available for competition or for parts of interaction networks, but these may not extend to more complex networks. Here we use metacommunity theory to develop new expectations for how complex networks will reorganize under environmental change, and show that dispersal is crucial for determining the degree to which networks will retain their composition and structure...
May 8, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812510/make-jeremy-hunt-read-ns
#9
Penny Mannings
Jeremy Hunt should be put in a darkened room with a supply of Nursing Standard and - over a 12-hour shift with a snatched toilet break/cup of coffee - forced to read from cover to cover.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28812319/poorly-differentiated-chordoma-with-loss-of-smarcb1-ini1-expression-in-pediatric-patients-a-report-of-two-cases-and-review-of-the-literature
#10
Yoon Jin Cha, Chang-Ki Hong, Dong-Seok Kim, Seung-Koo Lee, Hyeon Jin Park, Se Hoon Kim
Identification of loss of SMARCB1/INI1 expression in poorly differentiated (PD) chordoma in pediatric patients suggests that PD chordoma is an entity molecularly distinct from conventional chordoma or atypical teratoid/rhabdoid tumor, which is also characterized by loss of SMARCB1/INI1 expression by inactivating mutation of the SMARCB1/INI gene. So far, around 20 cases of pediatric PD chordoma with loss of SMARCB1/INI1 expression have been reported. Here, we report two cases of pediatric PD chordoma with loss of SMARCB1/INI1 expression, which is very rare among the pediatric chordoma types...
August 15, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28812196/convergent-validation-and-transfer-of-learning-studies-of-a-virtual-reality-based-pattern-cutting-simulator
#11
Arun Nemani, Woojin Ahn, Clairice Cooper, Steven Schwaitzberg, Suvranu De
INTRODUCTION: Research has clearly shown the benefits of surgical simulators to train laparoscopic motor skills required for positive patient outcomes. We have developed the Virtual Basic Laparoscopic Skill Trainer (VBLaST) that simulates tasks from the Fundamentals of Laparoscopic Surgery (FLS) curriculum. This study aims to show convergent validity of the VBLaST pattern cutting module via the CUSUM method to quantify learning curves along with motor skill transfer from simulation environments to ex vivo tissue samples...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28811540/ultralow-lattice-thermal-conductivity-of-the-random-multilayer-structure-with-lattice-imperfections
#12
Pranay Chakraborty, Lei Cao, Yan Wang
Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecular dynamics simulations are conducted to investigate phonon heat conduction in SLs and RMLs with lattice imperfections. We found that interfacial species mixing enhances thermal transport across single interfaces and few-period SLs through the phonon "bridge" mechanism, while it substantially reduces the κ l of many-period SLs by breaking the phonon coherence...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811466/time-lapse-crystallography-snapshots-of-a-double-strand-break-repair-polymerase-in-action
#13
Joonas A Jamsen, William A Beard, Lars C Pedersen, David D Shock, Andrea F Moon, Juno M Krahn, Katarzyna Bebenek, Thomas A Kunkel, Samuel H Wilson
DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides during gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair. Here we report time-lapse X-ray crystallography snapshots of catalytic events during gap-filling DNA synthesis by pol μ. Unique catalytic intermediates and active site conformational changes that underlie catalysis are uncovered, and a transient third (product) metal ion is observed in the product state. The product manganese coordinates phosphate oxygens of the inserted nucleotide and PPi...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811464/the-origin-of-a-primordial-genome-through-spontaneous-symmetry-breaking
#14
Nobuto Takeuchi, Paulien Hogeweg, Kunihiko Kaneko
The heredity of a cell is provided by a small number of non-catalytic templates-the genome. How did genomes originate? Here, we demonstrate the possibility that genome-like molecules arise from symmetry breaking between complementary strands of self-replicating molecules. Our model assumes a population of protocells, each containing a population of self-replicating catalytic molecules. The protocells evolve towards maximising the catalytic activities of the molecules to increase their growth rates. Conversely, the molecules evolve towards minimising their catalytic activities to increase their intracellular relative fitness...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811362/nuclear-envelope-rupture-is-enhanced-by-loss-of-p53-or-rb
#15
Zhe Yang, John Maciejowski, Titia de Lange
The mammalian nuclear envelope (NE) forms a stable physical barrier between the nucleus and the cytoplasm, normally breaking down only during the cell cycle phase of mitosis. However, spontaneous transient NE rupture in interphase can occur when NE integrity is compromised such as when the nucleus experiences mechanical stress. For instance, deficiencies in the nuclear lamins and their associated proteins can cause NE rupture that is promoted by forces exerted by actin filaments. NE rupture can allow cytoplasmic nucleases to access chromatin, potentially compromising genome integrity...
August 15, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28811095/can-the-optimum-artificial-tear-treatment-for-dry-eye-disease-be-predicted-from-presenting-signs-and-symptoms
#16
Laika Essa, Deborah Laughton, James S Wolffsohn
PURPOSE: To assess dry eye treatment with four preservative-free dry eye artificial tear treatments to facilitate evidence-based prescribing. METHODS: A randomised, single masked crossover trial of Clinitas Soothe, Hyabak, Tears Again and TheraTears artificial tears was conducted on 50 symptomatic dry eye patients, aged 60.8±14.2years. At baseline and after trialling each treatment for 4 weeks, signs and symptoms were assessed using the Ocular Surface Disease Index (OSDI), non-invasive tear break-up time, fluorescein tear break-up time, tear meniscus height (TMH), Phenol Red test, lid-parallel conjunctival folds (LIPCOF), ocular surface staining, and lipid layer grading and osmolarity (baseline visit only)...
August 12, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28810894/chikungunya-an-emerging-viral-infection-with-varied-clinical-presentations-in-bangladesh-reports-of-seven-cases
#17
Muhammad Abdur Rahim, Khwaja Nazim Uddin
BACKGROUND: Chikungunya is an emerging and rapidly spreading viral infection in many parts of the world including Bangladesh. It shares many epidemiological and clinical characteristics with dengue. So, a sound knowledge is required for its detection and differentiation from dengue, specially in endemic regions. CASE PRESENTATION: We present seven confirmed cases of chikungunya having different clinical presentations occurring among middle aged males and females from different socio-economic background in Dhaka city, the capital of Bangladesh...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28810781/projected-coupled-cluster-theory
#18
Yiheng Qiu, Thomas M Henderson, Jinmo Zhao, Gustavo E Scuseria
Coupled cluster theory is the method of choice for weakly correlated systems. But in the strongly correlated regime, it faces a symmetry dilemma, where it either completely fails to describe the system or has to artificially break certain symmetries. On the other hand, projected Hartree-Fock theory captures the essential physics of many kinds of strong correlations via symmetry breaking and restoration. In this work, we combine and try to retain the merits of these two methods by applying symmetry projection to broken symmetry coupled cluster wave functions...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810778/hydrogen-bond-network-rearrangement-dynamics-in-water-clusters-effects-of-intermolecular-vibrational-excitation-on-tunneling-rates
#19
William T S Cole, Richard J Saykally
Theoretical studies of hydrogen bond network rearrangement (HBNR) dynamics in liquid water have indicated that librational motions initiate the hydrogen bond breaking/formation processes. We present the results of using a simple time evolution method to extract and compare the tunneling lifetimes for motions that break and reform the hydrogen bond for the water dimer, trimer, and pentamer from the experimentally measured tunneling splittings in the ground and excited intermolecular vibrational states. We find that the specific nature of the intermolecular vibrational excitation does not significantly influence the tunneling lifetime of the dimer, but that only excitations to a librational vibration affect the water trimer and pentamer lifetimes...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810773/geometric-phase-effects-in-excited-state-dynamics-through-a-conical-intersection-in-large-molecules-n-dimensional-linear-vibronic-coupling-model-study
#20
Jiaru Li, Loïc Joubert-Doriol, Artur F Izmaylov
We investigate geometric phase (GP) effects in nonadiabatic transitions through a conical intersection (CI) in an N-dimensional linear vibronic coupling (ND-LVC) model. This model allows for the coordinate transformation encompassing all nonadiabatic effects within a two-dimensional (2D) subsystem, while the other N - 2 dimensions form a system of uncoupled harmonic oscillators identical for both electronic states and coupled bi-linearly with the subsystem coordinates. The 2D subsystem governs ultra-fast nonadiabatic dynamics through the CI and provides a convenient model for studying GP effects...
August 14, 2017: Journal of Chemical Physics
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