Michael Satchell, Blaine Fry, Zahraa Noureddine, Alexis Simmons, Nicolette N Ognjanovski, Sara J Aton, Michal R Zochowski
UNLABELLED: Across vertebrate species, sleep consists of repeating cycles of NREM followed by REM. However, the respective functions of NREM, REM, and their stereotypic cycling pattern are not well understood. Using a simplified biophysical network model, we show that NREM and REM sleep can play differential and critical roles in memory consolidation primarily regulated, based on state-specific changes in cholinergic signaling. Within this network, decreasing and increasing muscarinic acetylcholine (ACh) signaling during bouts of NREM and REM, respectively, differentially alters neuronal excitability and excitatory/inhibitory balance...
January 16, 2024: bioRxiv