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Nicolette Ognjanovski, Samantha Schaeffer, Jiaxing Wu, Sima Mofakham, Daniel Maruyama, Michal Zochowski, Sara J Aton
Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory formation. We find that in the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (which typically express parvalbumin (PV)) show greater firing coherence with CA1 network oscillations. Post-CFC inhibition of PV+ interneurons blocks fear memory consolidation. This effect is associated with loss of two network changes associated with normal consolidation: (1) augmented sleep-associated delta (0...
April 6, 2017: Nature Communications
Sneha Challa, Abubakar Manu, Emmanuel Morhe, Vanessa K Dalton, Dana Loll, Jessica Dozier, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Kelli Stidham Hall
Little is known about the multilevel social determinants of adolescent sexual and reproductive health (SRH) that shape the use of family planning (FP) among young women in Africa. We conducted in-depth, semi-structured, qualitative interviews with 63 women aged 15-24 years in Accra and Kumasi, Ghana. We used purposive, stratified sampling to recruit women from community-based sites. Interviews were conducted in English or local languages, recorded, and transcribed verbatim. Grounded theory-guided thematic analysis identified salient themes...
March 15, 2017: Women & Health
Kelli Stidham Hall, Abubakar Manu, Emmanuel Morhe, Lisa H Harris, Dana Loll, Elizabeth Ela, Giselle Kolenic, Jessica L Dozier, Sneha Challa, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Vanessa K Dalton
Young women's experiences with sexual and reproductive health (SRH) stigma may contribute to unintended pregnancy. Thus, stigma interventions and rigorous measures to assess their impact are needed. Based on formative work, we generated a pool of 51 items on perceived stigma around different dimensions of adolescent SRH and family planning (sex, contraception, pregnancy, childbearing, abortion). We tested items in a survey study of 1,080 women ages 15 to 24 recruited from schools, health facilities, and universities in Ghana...
March 7, 2017: Journal of Sex Research
Kelli Stidham Hall, Vanessa K Dalton, Melissa Zochowski, Timothy R B Johnson, Lisa H Harris
Objective Little is known about how women's social context of unintended pregnancy, particularly adverse social circumstances, relates to their general health and wellbeing. We explored associations between stressful life events around the time of unintended pregnancy and physical and mental health. Methods Data are drawn from a national probability study of 1078 U.S. women aged 18-55. Our internet-based survey measured 14 different stressful life events occurring at the time of unintended pregnancy (operationalized as an additive index score), chronic disease and mental health conditions, and current health and wellbeing symptoms (standardized perceived health, depression, stress, and discrimination scales)...
January 25, 2017: Maternal and Child Health Journal
E Shtrahman, D Maruyama, E Olariu, C G Fink, M Zochowski
Astrocytes form interconnected networks in the brain and communicate via calcium signaling. We investigate how modes of coupling between astrocytes influence the spatio-temporal patterns of calcium signaling within astrocyte networks and specifically how these network interactions promote coordination within this group of cells. To investigate these complex phenomena, we study reduced cultured networks of astrocytes and neurons. We image the spatial temporal patterns of astrocyte calcium activity and quantify how perturbing the coupling between astrocytes influences astrocyte activity patterns...
January 27, 2017: Physical Biology
Scott Rich, Victoria Booth, Michal Zochowski
The plethora of inhibitory interneurons in the hippocampus and cortex play a pivotal role in generating rhythmic activity by clustering and synchronizing cell firing. Results of our simulations demonstrate that both the intrinsic cellular properties of neurons and the degree of network connectivity affect the characteristics of clustered dynamics exhibited in randomly connected, heterogeneous inhibitory networks. We quantify intrinsic cellular properties by the neuron's current-frequency relation (IF curve) and Phase Response Curve (PRC), a measure of how perturbations given at various phases of a neurons firing cycle affect subsequent spike timing...
2016: Frontiers in Neural Circuits
Katherine He, Vanessa K Dalton, Melissa K Zochowski, Kelli Stidham Hall
BACKGROUND: Family planning research has not adequately addressed women's preferences for different contraceptive methods and whether women's contraceptive experiences match their preferences. METHODS: Data were drawn from the Women's Healthcare Experiences and Preferences Study, an Internet survey of 1,078 women aged 18-55 randomly sampled from a national probability panel. Survey items assessed women's preferences for contraceptive methods, match between methods preferred and used, and perceived reasons for mismatch...
October 6, 2016: Journal of Women's Health
James P Roach, Leonard M Sander, Michal R Zochowski
The brain can reproduce memories from partial data; this ability is critical for memory recall. The process of memory recall has been studied using autoassociative networks such as the Hopfield model. This kind of model reliably converges to stored patterns that contain the memory. However, it is unclear how the behavior is controlled by the brain so that after convergence to one configuration, it can proceed with recognition of another one. In the Hopfield model, this happens only through unrealistic changes of an effective global temperature that destabilizes all stored configurations...
May 2016: Physical Review. E
Janina Brand, Katharina Voigt, Bianca Zochowski, Ulrich Kulozik
The application of membrane adsorbers instead of classical packed bed columns for protein fractionation is still a growing field. In the case of egg white protein fractionation, the application of classical chromatography is additionally limited due to its high viscosity that impairs filtration. By using tangential flow membrane adsorbers as stationary phase this limiting factor can be left out, as they can be loaded with particle containing substrates. The flow conditions existing in tangential flow membrane adsorbers are not fully understood yet...
March 18, 2016: Journal of Chromatography. A
Kelli Stidham Hall, Elizabeth Ela, Melissa K Zochowski, Amy Caldwell, Michelle Moniz, Laura McAndrew, Monique Steel, Sneha Challa, Vanessa K Dalton, Susan Ernst
OBJECTIVE: To assess multiple dimensions of long-acting reversible contraception (LARC) knowledge and perceived multi-level barriers to LARC use among a sample of college women. STUDY DESIGN: We conducted an Internet-based study of 1982 female undergraduates at a large mid-western university. Our 55-item survey used a multi-level framework to measure young women's understanding of, experiences with intrauterine devices (IUD) and implants and their perceived barriers to LARC at individual, health systems and community levels...
June 2016: Contraception
Scott Knudstrup, Michal Zochowski, Victoria Booth
The characteristics of neural network activity depend on intrinsic neural properties and synaptic connectivity in the network. In brain networks, both of these properties are critically affected by the type and levels of neuromodulators present. The expression of many of the most powerful neuromodulators, including acetylcholine (ACh), varies tonically and phasically with behavioural state, leading to dynamic, heterogeneous changes in intrinsic neural properties and synaptic connectivity properties. Namely, ACh significantly alters neural firing properties as measured by the phase response curve in a manner that has been shown to alter the propensity for network synchronization...
May 2016: European Journal of Neuroscience
Benjamin Y Lu, Shivani U Thanawala, Kelly C Zochowski, Michael J Burke, William L Carroll, Teena Bhatla
No abstract text is available yet for this article.
August 2016: Leukemia & Lymphoma
Alexa Kaskowitz, Elisabeth Quint, Melissa Zochowski, Amy Caldwell, Kavita Vinekar, Vanessa K Dalton
STUDY OBJECTIVE: To characterize pediatricians' knowledge, attitudes, and self-efficacy around contraception. DESIGN: Cross-sectional survey. SETTING: United States. PARTICIPANTS: National sample of pediatricians. INTERVENTIONS: Assessment of behaviors of providing contraception. MAIN OUTCOME MEASURES: Reproductive health practice score. RESULTS: Two hundred twenty-three usable surveys were received, from 163 contraceptive prescribers and 60 nonprescribers...
November 25, 2015: Journal of Pediatric and Adolescent Gynecology
Alaina T Bennett, Divya A Patel, Ruth C Carlos, Melissa K Zochowski, Sarah M Pennewell, Alice M Chi, Vanessa K Dalton
BACKGROUND: Educational interventions may be a strategy to increase human papillomavirus (HPV) vaccination among female university students, but studies to date have shown mixed results. This study evaluated the effect of MeFirst, an individually tailored, online educational intervention, on HPV vaccine-related knowledge, vaccination intention, and uptake among previously unvaccinated female university students. METHODS: All female students aged 18-26 years who reported being unvaccinated against HPV at a midwestern university were invited via email to enroll...
November 2015: Journal of Women's Health
Thomas Zochowski, David Docherty
BACKGROUND: The aim of this paper was to determine the effects of using intermittent hand cooling during high intensity, intermittent training on thermoregulatory, performance and psychophysical variables in elite level swimmers in a training pool (30.5±0.5 °C). METHODS: Randomized cross-over design. Following a standard warm-up, ten male swimmers (20.3±3.2 years) were instructed to maintain the fastest 100-m time (on average) for an 8 x 100 m freestyle swimming set performed either in a training pool with cooling (TPC) or a training pool with no-cooling (TPNC)...
March 2016: Journal of Sports Medicine and Physical Fitness
James P Roach, Eshel Ben-Jacob, Leonard M Sander, Michal R Zochowski
Acetylcholine (ACh) is a regulator of neural excitability and one of the neurochemical substrates of sleep. Amongst the cellular effects induced by cholinergic modulation are a reduction in spike-frequency adaptation (SFA) and a shift in the phase response curve (PRC). We demonstrate in a biophysical model how changes in neural excitability and network structure interact to create three distinct functional regimes: localized asynchronous, traveling asynchronous, and traveling synchronous. Our results qualitatively match those observed experimentally...
August 2015: PLoS Computational Biology
Kelli Stidham Hall, Samantha Paturu Nadella, Melissa K Zochowski, Divya Patel, Vanessa K Dalton
BACKGROUND: Notably absent from research and public and policy dialogue on the Affordable Care Act (ACA) and reproductive health care are women's perspectives and a broader understanding of factors that shape ACA attitudes. We investigated social, reproductive, and attitudinal factors associated with women's disagreement with the passage of the ACA. METHODS: Data were drawn from the Women's Health Care Experiences and Preferences Study, our population-based internet survey of 1,078 randomly sampled United States women ages 18-55 years conducted in September 2013...
September 2015: Journal of Women's Health
Kelli Stidham Hall, Elizabeth W Patton, Halley P Crissman, Melissa K Zochowski, Vanessa K Dalton
OBJECTIVE: We characterized US women's preferred and usual sources of reproductive health care. STUDY DESIGN: Data were drawn from the Women's Health Care Experiences and Preferences Study, an Internet survey of 1078 women aged 18-55 years randomly sampled from a national probability panel. We described and compared women's preferred and usual sources of care (women's health specialists including obstetricians-gynecologists and family-planning clinics, primary care, other) for Papanicolaou/pelvic examination, contraception, and sexually transmitted infection (STI) services using χ(2), logistic regression, and kappa statistics...
September 2015: American Journal of Obstetrics and Gynecology
Halley Crissman, Kelli S Hall, Elizabeth Winston Patton, Melissa K Zochowski, Matthew M Davis, Vanessa Kathleen Dalton
INTRODUCTION: It is unclear how the Patient Protection and Affordable Care Act (ACA) will influence women's use of reproductive health care sources, including family planning clinics, which have traditionally played a key role in safety net services. We explored women's intended sources of care for contraception, pelvic exam/Pap test, and sexually transmitted infection (STI) testing services following passage of the ACA. METHODS: Data were drawn from a study of U...
May 2015: Obstetrics and Gynecology
Michael J Leone, Brandon N Schurter, Benjamin Letson, Victoria Booth, Michal Zochowski, Christian G Fink
We study the synchronization of neuronal networks with dynamical heterogeneity, showing that network structures with the same propensity for synchronization (as quantified by master stability function analysis) may develop dramatically different synchronization properties when heterogeneity is introduced with respect to neuronal excitability type. Specifically, we investigate networks composed of neurons with different types of phase response curves (PRCs), which characterize how oscillating neurons respond to excitatory perturbations...
March 2015: Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
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