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https://www.readbyqxmd.com/read/29608595/factors-associated-with-sexual-and-reproductive-health-stigma-among-adolescent-girls-in-ghana
#1
Kelli Stidham Hall, Emmanuel Morhe, Abubakar Manu, Lisa H Harris, Elizabeth Ela, Dana Loll, Giselle Kolenic, Jessica L Dozier, Sneha Challa, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Vanessa K Dalton
OBJECTIVE: Using our previously developed and tested Adolescent Sexual and Reproductive Health (SRH) Stigma Scale, we investigated factors associated with perceived SRH stigma among adolescent girls in Ghana. METHODS: We drew upon data from our survey study of 1,063 females 15-24yrs recruited from community- and clinic-based sites in two Ghanaian cities. Our Adolescent SRH Stigma Scale comprised 20 items and 3 sub-scales (Internalized, Enacted, Lay Attitudes) to measure stigma occurring with sexual activity, contraceptive use, pregnancy, abortion and family planning service use...
2018: PloS One
https://www.readbyqxmd.com/read/29545273/resonance-with-subthreshold-oscillatory-drive-organizes-activity-and-optimizes-learning-in-neural-networks
#2
James P Roach, Aleksandra Pidde, Eitan Katz, Jiaxing Wu, Nicolette Ognjanovski, Sara J Aton, Michal R Zochowski
Network oscillations across and within brain areas are critical for learning and performance of memory tasks. While a large amount of work has focused on the generation of neural oscillations, their effect on neuronal populations' spiking activity and information encoding is less known. Here, we use computational modeling to demonstrate that a shift in resonance responses can interact with oscillating input to ensure that networks of neurons properly encode new information represented in external inputs to the weights of recurrent synaptic connections...
March 15, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29295866/connexin-43-gap-junctions-contribute-to-brain-endothelial-barrier-hyperpermeability-in-familial-cerebral-cavernous-malformations-type-iii-by-modulating-tight-junction-structure
#3
Allison M Johnson, James P Roach, Anna Hu, Svetlana M Stamatovic, Michal R Zochowski, Richard F Keep, Anuska V Andjelkovic
Familial cerebral cavernous malformations type III (fCCM3) is a disease of the cerebrovascular system caused by loss-of-function mutations in ccm3 that result in dilated capillary beds that are susceptible to hemorrhage. Before hemorrhage, fCCM3 lesions are characterized by a hyperpermeable blood-brain barrier (BBB), the key pathologic feature of fCCM3. We demonstrate that connexin 43 (Cx43), a gap junction (GJ) protein that is incorporated into the BBB junction complex, is up-regulated in lesions of a murine model of fCCM3...
January 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28972957/comparison-of-different-oral-anticoagulant-regimens-in-patients-with-atrial-fibrillation-undergoing-ablation-or-cardioversion
#4
Monika Gawałko, Agnieszka Kapłon-Cieślicka, Monika Budnik, Aldona Babiarz, Aleksandra Bodys, Robert Uliński, Maciej Żochowski, Michał Peller, Piotr Scisło, Janusz Kochanowski, Krzysztof J Filipiak, Grzegorz Opolski
INTRODUCTION    Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative to vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF). OBJECTIVES    The aim of the study was to assess the incidence of left atrial appendage (LAA) thrombus and dense spontaneous echo contrast (SEC), as well as to compare the clinical characteristics of patients with AF treated with different anticoagulant regimens. PATIENTS AND METHODS    We studied 1033 consecutive patients with AF, who underwent transesophageal echocardiography (TEE) before AF ablation or cardioversion...
December 22, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28917089/the-trehalose-specific-transporter-lpqy-sugabc-is-required-for-antimicrobial-and-anti-biofilm-activity-of-trehalose-analogues-in-mycobacterium-smegmatis
#5
Jeffrey M Wolber, Bailey L Urbanek, Lisa M Meints, Brent F Piligian, Irene C Lopez-Casillas, Kailey M Zochowski, Peter J Woodruff, Benjamin M Swarts
Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess distinctive pathways for synthesizing and utilizing the non-mammalian disaccharide trehalose. Trehalose metabolism is essential for mycobacterial viability and has been linked to in vitro biofilm formation, which may bear relevance to in vivo drug tolerance. Previous research has shown that some trehalose analogues bearing modifications at the 6-position inhibit growth of various mycobacterial species. In this work, 2-, 5-, and 6-position-modified trehalose analogues were synthesized using our previously reported one-step chemoenzymatic method and shown to inhibit growth and biofilm formation in the two-to three-digit micromolar range in Mycobacterium smegmatis...
October 10, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28893999/cortically-coordinated-nrem-thalamocortical-oscillations-play-an-essential-instructive-role-in-visual-system-plasticity
#6
Jaclyn Durkin, Aneesha K Suresh, Julie Colbath, Christopher Broussard, Jiaxing Wu, Michal Zochowski, Sara J Aton
Two long-standing questions in neuroscience are how sleep promotes brain plasticity and why some forms of plasticity occur preferentially during sleep vs. wake. Establishing causal relationships between specific features of sleep (e.g., network oscillations) and sleep-dependent plasticity has been difficult. Here we demonstrate that presentation of a novel visual stimulus (a single oriented grating) causes immediate, instructive changes in the firing of mouse lateral geniculate nucleus (LGN) neurons, leading to increased firing-rate responses to the presented stimulus orientation (relative to other orientations)...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28681846/erratum-parvalbumin-expressing-interneurons-coordinate-hippocampal-network-dynamics-required-for-memory-consolidation
#7
Nicolette Ognjanovski, Samantha Schaeffer, Jiaxing Wu, Sima Mofakham, Daniel Maruyama, Michal Zochowski, Sara J Aton
This corrects the article DOI: 10.1038/ncomms15039.
July 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28659842/functional-synchronization-the-emergence-of-coordinated-activity-in-human-systems
#8
Andrzej Nowak, Robin R Vallacher, Michal Zochowski, Agnieszka Rychwalska
The topical landscape of psychology is highly compartmentalized, with distinct phenomena explained and investigated with recourse to theories and methods that have little in common. Our aim in this article is to identify a basic set of principles that underlie otherwise diverse aspects of human experience at all levels of psychological reality, from neural processes to group dynamics. The core idea is that neural, behavioral, mental, and social structures emerge through the synchronization of lower-level elements (e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28614147/rate-of-and-risk-factors-for-intermediate-term-reoperation-after-ankle-fracture-fixation-a-population-based-cohort-study
#9
Daniel Pincus, Andrea Veljkovic, Thomas Zochowski, Nizar Mahomed, Darrell Ogilivie-Harris, David Wasserstein
OBJECTIVE: Establish baseline rates of and risk factors for reoperation within 1 or 2 years of ankle open reduction internal fixation (ORIF). DESIGN: Retrospective, population-based cohort study. SETTING: Two hundred two hospitals in Ontario, Canada (approximate population 13.6 million in 2014). PATIENTS/PARTICIPANTS: Forty five thousand four hundred forty-four patients who underwent ankle ORIF performed by 710 different surgeons between January 1, 1994, and December 31, 2011...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28485838/involvement-and-comfort-of-gynecologic-oncologists-in-the-treatment-of-pediatric-adolescent-and-young-adult-patients-with-gynecologic-malignancies
#10
Ira Winer, Divya Patel, Vanessa Dalton, Carolyn Johnston, Elisabeth H Quint, Melissa Zochowski, Adnan Munkarah, Robert Morris, Hope Haefner
OBJECTIVE: To investigate the provision of care for pediatric and adolescent patients by gynecologic oncologists. METHODS: The present prospective cross-sectional study enrolled attending physicians and fellows specializing in gynecologic oncology from the USA during December 2012 and January 2013. A 33-question survey collecting demographic data and details of participant opinions on existing practices was distributed to potential respondents. Survey responses were aggregated and descriptive analyses were performed...
August 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28382952/parvalbumin-expressing-interneurons-coordinate-hippocampal-network-dynamics-required-for-memory-consolidation
#11
Nicolette Ognjanovski, Samantha Schaeffer, Jiaxing Wu, Sima Mofakham, Daniel Maruyama, Michal Zochowski, Sara J Aton
Activity in hippocampal area CA1 is essential for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory formation. We find that in the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (which typically express parvalbumin (PV)) show greater firing coherence with CA1 network oscillations. Post-CFC inhibition of PV+ interneurons blocks fear memory consolidation. This effect is associated with loss of two network changes associated with normal consolidation: (1) augmented sleep-associated delta (0...
April 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28296626/multiple-levels-of-social-influence-on-adolescent-sexual-and-reproductive-health-decision-making-and-behaviors-in-ghana
#12
Sneha Challa, Abubakar Manu, Emmanuel Morhe, Vanessa K Dalton, Dana Loll, Jessica Dozier, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Kelli Stidham Hall
Little is known about the multilevel social determinants of adolescent sexual and reproductive health (SRH) that shape the use of family planning (FP) among young women in Africa. We conducted in-depth, semi-structured, qualitative interviews with 63 women aged 15-24 years in Accra and Kumasi, Ghana. We used purposive, stratified sampling to recruit women from community-based sites. Interviews were conducted in English or local languages, recorded, and transcribed verbatim. Grounded theory-guided thematic analysis identified salient themes...
March 15, 2017: Women & Health
https://www.readbyqxmd.com/read/28266874/development-and-validation-of-a-scale-to-measure-adolescent-sexual-and-reproductive-health-stigma-results-from-young-women-in-ghana
#13
Kelli Stidham Hall, Abubakar Manu, Emmanuel Morhe, Lisa H Harris, Dana Loll, Elizabeth Ela, Giselle Kolenic, Jessica L Dozier, Sneha Challa, Melissa K Zochowski, Andrew Boakye, Richard Adanu, Vanessa K Dalton
Young women's experiences with sexual and reproductive health (SRH) stigma may contribute to unintended pregnancy. Thus, stigma interventions and rigorous measures to assess their impact are needed. Based on formative work, we generated a pool of 51 items on perceived stigma around different dimensions of adolescent SRH and family planning (sex, contraception, pregnancy, childbearing, abortion). We tested items in a survey study of 1,080 women ages 15 to 24 recruited from schools, health facilities, and universities in Ghana...
January 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/28120290/stressful-life-events-around-the-time-of-unplanned-pregnancy-and-women-s-health-exploratory-findings-from-a-national-sample
#14
Kelli Stidham Hall, Vanessa K Dalton, Melissa Zochowski, Timothy R B Johnson, Lisa H Harris
Objective Little is known about how women's social context of unintended pregnancy, particularly adverse social circumstances, relates to their general health and wellbeing. We explored associations between stressful life events around the time of unintended pregnancy and physical and mental health. Methods Data are drawn from a national probability study of 1078 U.S. women aged 18-55. Our internet-based survey measured 14 different stressful life events occurring at the time of unintended pregnancy (operationalized as an additive index score), chronic disease and mental health conditions, and current health and wellbeing symptoms (standardized perceived health, depression, stress, and discrimination scales)...
June 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28004641/understanding-spatial-and-temporal-patterning-of-astrocyte-calcium-transients-via-interactions-between-network-transport-and-extracellular-diffusion
#15
E Shtrahman, D Maruyama, E Olariu, C G Fink, M Zochowski
Astrocytes form interconnected networks in the brain and communicate via calcium signaling. We investigate how modes of coupling between astrocytes influence the spatio-temporal patterns of calcium signaling within astrocyte networks and specifically how these network interactions promote coordination within this group of cells. To investigate these complex phenomena, we study reduced cultured networks of astrocytes and neurons. We image the spatial temporal patterns of astrocyte calcium activity and quantify how perturbing the coupling between astrocytes influences astrocyte activity patterns...
January 27, 2017: Physical Biology
https://www.readbyqxmd.com/read/27812323/intrinsic-cellular-properties-and-connectivity-density-determine-variable-clustering-patterns-in-randomly-connected-inhibitory-neural-networks
#16
Scott Rich, Victoria Booth, Michal Zochowski
The plethora of inhibitory interneurons in the hippocampus and cortex play a pivotal role in generating rhythmic activity by clustering and synchronizing cell firing. Results of our simulations demonstrate that both the intrinsic cellular properties of neurons and the degree of network connectivity affect the characteristics of clustered dynamics exhibited in randomly connected, heterogeneous inhibitory networks. We quantify intrinsic cellular properties by the neuron's current-frequency relation (IF curve) and Phase Response Curve (PRC), a measure of how perturbations given at various phases of a neurons firing cycle affect subsequent spike timing...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27710196/women-s-contraceptive-preference-use-mismatch
#17
Katherine He, Vanessa K Dalton, Melissa K Zochowski, Kelli Stidham Hall
BACKGROUND: Family planning research has not adequately addressed women's preferences for different contraceptive methods and whether women's contraceptive experiences match their preferences. METHODS: Data were drawn from the Women's Healthcare Experiences and Preferences Study, an Internet survey of 1,078 women aged 18-55 randomly sampled from a national probability panel. Survey items assessed women's preferences for contraceptive methods, match between methods preferred and used, and perceived reasons for mismatch...
June 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/27300910/memory-recall-and-spike-frequency-adaptation
#18
James P Roach, Leonard M Sander, Michal R Zochowski
The brain can reproduce memories from partial data; this ability is critical for memory recall. The process of memory recall has been studied using autoassociative networks such as the Hopfield model. This kind of model reliably converges to stored patterns that contain the memory. However, it is unclear how the behavior is controlled by the brain so that after convergence to one configuration, it can proceed with recognition of another one. In the Hopfield model, this happens only through unrealistic changes of an effective global temperature that destabilizes all stored configurations...
May 2016: Physical Review. E
https://www.readbyqxmd.com/read/26898148/lysozyme-fractionation-from-egg-white-at-pilot-scale-by-means-of-tangential-flow-membrane-adsorbers-investigation-of-the-flow-conditions
#19
Janina Brand, Katharina Voigt, Bianca Zochowski, Ulrich Kulozik
The application of membrane adsorbers instead of classical packed bed columns for protein fractionation is still a growing field. In the case of egg white protein fractionation, the application of classical chromatography is additionally limited due to its high viscosity that impairs filtration. By using tangential flow membrane adsorbers as stationary phase this limiting factor can be left out, as they can be loaded with particle containing substrates. The flow conditions existing in tangential flow membrane adsorbers are not fully understood yet...
March 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/26879627/-i-don-t-know-enough-to-feel-comfortable-using-them-women-s-knowledge-of-and-perceived-barriers-to-long-acting-reversible-contraceptives-on-a-college-campus
#20
Kelli Stidham Hall, Elizabeth Ela, Melissa K Zochowski, Amy Caldwell, Michelle Moniz, Laura McAndrew, Monique Steel, Sneha Challa, Vanessa K Dalton, Susan Ernst
OBJECTIVE: To assess multiple dimensions of long-acting reversible contraception (LARC) knowledge and perceived multi-level barriers to LARC use among a sample of college women. STUDY DESIGN: We conducted an Internet-based study of 1982 female undergraduates at a large mid-western university. Our 55-item survey used a multi-level framework to measure young women's understanding of, experiences with intrauterine devices (IUD) and implants and their perceived barriers to LARC at individual, health systems and community levels...
June 2016: Contraception
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