Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling, Tamás Radovits
BACKGROUND: Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory responses, mitochondrial proteins, extracellular remodeling and estrogen-mediated cardioprotective signaling pathways related to post-ischemic recovery, which were associated with better cardiac functional outcomes in females. We aimed to investigate the early, sex-specific functional and proteomic changes following myocardial ischemia in an unbiased approach...
December 11, 2021: Journal of Translational Medicine