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Hiroaki Nakashima, Shiro Imagama, Hideki Yagi, Fumihiko Kato, Tokumi Kanemura, Koji Sato, Noriaki Kawakami, Mitsuhiro Kamiya, Hisatake Yoshihara, Kenyu Ito, Yukihiro Matsuyama, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: Retrospective multicenter case-controlled study OBJECTIVE.: The aim of this study was to investigate the clinical and radiographical differences between thoracic idiopathic spinal cord herniation (ISCH) and spinal arachnoid cyst (SAC). SUMMARY AND BACKGROUND DATA: ISCH and SAC are relatively rare diseases. Preoperative misdiagnose was frequently reported in both, however these clinical and radiographical differences remain unclear. METHODS: Out of 30,469 patients who underwent spinal surgery, 18 (0...
December 6, 2016: Spine
Abdullah Alkhamees, Francois Proust
Idiopathic spinal cord herniation (ISCH) is a rare cause of progressive spinal myelopathy, which frequently presents as Brown-Sequard syndrome. A 50 year old woman consulted for difficulty in walking. On examination, the patient reported sensory deficit of temperature on the left side, associated with diminished anal sensitivity. Nine months before consultation, a walking disorder began disturbing the activities of everyday life. A single case report with surgical treatment outcome. Idiopathic spinal cord herniation is a potentially treatable condition, which should be diagnosed early and treated...
October 2016: International Journal of Health Sciences
Pedro David Delgado-López, Cecilia Gil-Polo, Vicente Martín-Velasco, Javier Martín-Alonso, Ana María Galacho-Harriero, Elena Araus-Galdós
Idiopathic spinal cord herniation (ISCH) is a relatively rare and frequently misdiagnosed condition. It preferentially affects women and causes progressive thoracic myelopathy that presents as a Brown-Séquard syndrome or as spastic paraparesis. Although its etiology and pathogenesis are controversial, ISCH is characterized by the presence of an anterior dural defect that allows the incarceration of a segment of the cord. Typically, a C-shaped ventral displacement and kinking of the cord are visible on sagittal MRI...
November 4, 2016: Journal of Neurosurgery. Spine
Mahsa Ranji, Mohammad Masoudi Motlagh, Fahimeh Salehpour, Reyhaneh Sepehr, James S Heisner, Ranjan K Dash, Amadou K S Camara
Oxidation of substrates to generate ATP in mitochondria is mediated by redox reactions of NADH and FADH2. Cardiac ischemia and reperfusion (IR) injury compromises mitochondrial oxidative phosphorylation. We hypothesize that IR alters the metabolic heterogeneity of mitochondrial redox state of the heart that is only evident in the 3-D optical cryoimaging of the perfused heart before, during, and after IR. The study involved four groups of hearts: time control (TC: heart perfusion without IR), global ischemia (Isch), global ischemia followed by reperfusion (IR) and TC with PCP (a mitochondrial uncoupler) perfusion...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Shuo-Bin Chen, Ming-Hao Hu, Guo-Cai Liu, Jin Wang, Tian-Miao Ou, Lian-Quan Gu, Zhi-Shu Huang, Jia-Heng Tan
The RNA G-quadruplex is an important secondary structure formed by guanine-rich RNA sequences. However, its folding studies have mainly been studied in vitro. Accurate identification of RNA G-quadruplex formation within a sequence of interest remains difficult in cells. Herein, and based on the guanine-rich sequence in the 5'-UTR of NRAS mRNA, we designed and synthesized the first G-quadruplex-triggered fluorogenic hybridization (GTFH) probe, ISCH-nras1, for the unique visualization of the G-quadruplexes that form in this region...
August 24, 2016: Journal of the American Chemical Society
Luca Pagano, Alia D Servin, Roberto De La Torre-Roche, Arnab Mukherjee, Sanghamitra Majumdar, Joseph Hawthorne, Marta Marmiroli, Elena Maestri, Robert E Marra, Susan M Isch, Om Parkash Dhankher, Jason C White, Nelson Marmiroli
Functional toxicology has enabled the identification of genes involved in conferring tolerance and sensitivity to engineered nanomaterial (ENM) exposure in the model plant Arabidopsis thaliana (L.) Heynh. Several genes were found to be involved in metabolic functions, stress response, transport, protein synthesis, and DNA repair. Consequently, analysis of physiological parameters, metal content (through ICP-MS quantification), and gene expression (by RT-qPCR) of A. thaliana orthologue genes were performed across different plant species of agronomic interest to highlight putative biomarkers of exposure and effect related to ENMs...
July 5, 2016: Environmental Science & Technology
Michael Payer, Dominik Zumsteg, Nicolas De Tribolet, Stephan Wetzel
Idiopathic spinal cord herniation (ISCH) is a rare spinal disease, in which chronic cerebrospinal fluid pulsations push the arachnoid and adjacent thoracic spinal cord region through an antero-lateral dural defect of congenital, post-traumatic, or inflammatory/erosive origin. Symptomatic patients commonly present around the 5th decade of life with slowly progressive myelopathy. Diagnosis relies on high-resolution magnetic resonance imaging. Stable mild cases may be observed, whereas in progressive symptomatic situations, surgical spinal cord reposition and dural defect repair with a dural patch is the preferred treatment...
August 2016: Acta Neurochirurgica
Dilina Rajapakse, Leah Mapara, Sathiyaseelan Maniharan
Idiopathic spinal cord herniation (ISCH) is a recognised rare cause of progressive and potentially curable myelopathy. Around 170 cases have been described in the literature, all to be found between the T2 and T8 vertebrae. We report a case of ISCH in the cervical region. A 23-year-old man with no history of trauma presented with a 6-year history of bilateral mild resting hand tremor and left scapular pain radiating to the left arm for a duration of 8 months. Nerve conduction studies showed some denervation changes of the upper limbs and bulbar regions...
May 17, 2016: BMJ Case Reports
Yang Xu, Renjie Ji, Ruili Wei, Bo Yin, Fangping He, Benyan Luo
BACKGROUND: Inconsistent results have been reported for hyperbaric oxygen therapy (HBO) for acute stroke. We conducted a systematic review and meta-analysis to evaluate the benefit of HBO in animal studies of middle cerebral artery occlusion (MCAO). METHODS: A systematic search of the literature published prior to September 2015 was performed using Embase, Medline (OvidSP), Web of Science and PubMed. Keywords included "hyperoxia" OR "hyperbaric oxygen" OR "HBO" AND "isch(a)emia" OR "focal cerebral ischemia" OR "stroke" OR "infarct" OR "middle cerebral artery occlusion (MCAO)...
2016: PloS One
Mahmood Ghasemi, Mehdi Nematbakhsh, Fatemeh Daneshmand, Maryam Moeini, Ardeshir Talebi
BACKGROUND: Renal ischemia-reperfusion (RIR) is a major cause of renal dysfunction that acts through different mechanisms. We investigated the role of L-Arginine as an endogenous nitric oxide (NO) precursor and NG-nitro-L-Arginine methyl ester (L-NAME) as an NO inhibitor on kidney and liver function in RIR model. MATERIALS AND METHODS: Fifty-eight Wistar rats were randomly assigned to four groups. Groups 1 (sham-operated, n = 13) received a single dose of saline (4 ml/kg, i...
2015: Advanced Biomedical Research
Tamás Baranyai, Csilla Terézia Nagy, Gábor Koncsos, Zsófia Onódi, Melinda Károlyi-Szabó, András Makkos, Zoltán V Varga, Péter Ferdinandy, Zoltán Giricz
BACKGROUND: Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been studied so far. Therefore, here we investigated the effect of acute hyperglycemia on cardioprotection by RIPerC...
November 18, 2015: Cardiovascular Diabetology
Ekwutosi M Okoroh, Sheree L Boulet, Mary G George, W Craig Hooper
INTRODUCTION: No study has examined how the relationship between polycystic ovary syndrome (PCOS) and atherosclerotic cardiovascular diseases (aCVD), of ischemic stroke (ISCH), acute myocardial infarction (AMI), and peripheral vascular disease (PAD), differ in the presence of venous thromboembolism (VTE). MATERIALS AND METHODS: We performed a cross-sectional analysis using Truven Health Analytics MarketScan® Commercial databases from 2004-2011. The association between women aged 18-64 years with and without PCOS, and aCVD was assessed using VTE-stratified multivariable logistic regression models...
December 2015: Thrombosis Research
L F Liu, Z H Qian, Q Qin, M Shi, H Zhang, X M Tao, W P Zhu
We aimed to evaluate the effect of melatonin on myo-cardial cell oncosis in the myocardial ischemia/reperfusion injury rat, and the role of the mitochondrial permeability transition pore (MPTP) therein. Sprague Dawley rats (N = 60) were randomly divided into five groups of 12 rats each: control, ischemia/reperfusion (I/R), melatonin treatment (MT), melatonin treatment + atractyloside (MT+ATR), and atractyloside (ATR). We prepared the myocardial ischemia/reperfusion model by reperfusion after the left anterior descending coronary artery was ligated for 30 min...
2015: Genetics and Molecular Research: GMR
K Ran, Z X Gong, D L Yang, Y T Chang, K M Duan, Y W Ou
This study aimed to investigate the protective effects of delayed morphine preconditioning on myocardial ischemia-reperfusion injury. We randomly divided 30 rabbits into three groups with 10 rab-bits in each group as follows: sham operation group (C group), isch-emia-reperfusion group (I/R group), and morphine pretreatment group (M group). Rabbits in C Group received left coronary without blocking for 160 min. The left descending artery of rabbits in the I/R group was blocked for 40 min and reperfused for 120 min...
2015: Genetics and Molecular Research: GMR
Britton J Carter, Brent D Griffith, Lonni R Schultz, Muwaffak M Abdulhak, Daniel S Newman, Rajan Jain
BACKGROUND CONTEXT: Idiopathic spinal cord herniation (ISCH) is an underrecognized entity that is often underappreciated by the neurosurgery and neuroradiologic communities. This leads to delayed diagnosis, multiple imaging studies, other diagnostic tests, inappropriate surgeries, and repeat office visits. PURPOSE: To evaluate common associations between ISCH and patient demographics/clinical presentation and to analyze the potential for delayed diagnosis. PATIENT SAMPLE: Patient sample included those diagnosed with ISCH on imaging at our institution from June 20, 2005 to December 3, 2012...
September 1, 2015: Spine Journal: Official Journal of the North American Spine Society
Yichuan Liu, Michael Morley, Jeffrey Brandimarto, Sridhar Hannenhalli, Yu Hu, Euan A Ashley, W H Wilson Tang, Christine S Moravec, Kenneth B Margulies, Thomas P Cappola, Mingyao Li
Heart failure is a complex clinical syndrome and has become the most common reason for adult hospitalization in developed countries. Two subtypes of heart failure, ischemic heart disease (ISCH) and dilated cardiomyopathy (DCM), have been studied using microarray platforms. However, microarray has limited resolution. Here we applied RNA sequencing (RNA-Seq) to identify gene signatures for heart failure from six individuals, including three controls, one ISCH and two DCM patients. Using genes identified from this small RNA-Seq dataset, we were able to accurately classify heart failure status in a much larger set of 313 individuals...
February 2015: Genomics
Aleksandra Hodor, Svitlana Palchykova, Francesca Baracchi, Daniela Noain, Claudio L Bassetti
OBJECTIVE: Sleep disruption in the acute phase after stroke has detrimental effects on recovery in both humans and animals. Conversely, the effect of sleep promotion remains unclear. Baclofen (Bac) is a known non-rapid eye movement (NREM) sleep-promoting drug in both humans and animals. The aim of this study was to investigate the effect of Bac on stroke recovery in a rat model of focal cerebral ischemia (isch). METHODS: Rats, assigned to three experimental groups (Bac/isch, saline/isch, or Bac/sham), were injected twice daily for 10 consecutive days with Bac or saline, starting 24 h after induction of stroke...
October 2014: Annals of Clinical and Translational Neurology
Jon Berg-Johnsen, Eivind Ilstad, Frode Kolstad, Mark Züchner, Jarle Sundseth
Idiopathic spinal cord herniation (ISCH), where a segment of the spinal cord has herniated through a ventral defect in the dura, is a rarely encountered cause of thoracic myelopathy. The purpose of our study was to increase the clinical awareness of this condition by presenting our experience with seven consecutive cases treated in our department since 2005. All the patients developed pronounced spastic paraparesis or Brown-Séquard syndrome for several years (mean, 4.7 years) prior to diagnosis. MRI was consistent with a transdural spinal cord herniation in the mid-thoracic region in all the cases...
2014: Journal of Central Nervous System Disease
H Knapp
No abstract text is available yet for this article.
1880: Transactions of the American Ophthalmological Society
Ammar H Hawasli, Wilson Z Ray, Neill M Wright
BACKGROUND AND IMPORTANCE: Idiopathic spinal cord herniation (ISCH) is an uncommon condition located predominantly in the thoracic spine and often associated with a remote history of a major traumatic injury. ISCH has an incompletely described presentation and unknown etiology. There is no consensus on the treatment algorithm and surgical technique, and there are few data on clinical outcomes. CLINICAL PRESENTATION: In this case series and technical report, we describe the atypical myelopathy presentation, remote history of traumatic injury, radiographic progression, treatment, and outcomes of 5 patients treated at Washington University for symptomatic ISCH...
September 2014: Neurosurgery
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