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Clinial genetics

K Dilek, A A Ozçimen, H Saricaoğlu, D Saba, A Yücel, M Yurtkuran, M Yurtkuran, H B Oral
The association of the cytokine gene polymorphisms with the development of Behçet's Disease (BD) was investigated in this study. DNA samples were obtained from a Turkish population of 97 unrelated patients with BD, and 127 unrelated healthy control subjects.All genotyping (IL-6, IL10, IFN-gamma, TGF-Beta1 and TNF-alpha) experiments were performed using sequence-specific primers PCR. The frequency of TGF-Beta1 codon 25 GG genotype was found significantly lower in BD patients compared to healthy control subjects...
March 2009: Clinical and Experimental Rheumatology
R J Hoffmann
Electrophoretic surveys have demonstrated that populations of the sea anemone Metridium senile along the northeast coast of the United States are polymorphic at four enzyme loci. Phosphoglucose isomerase (PGI) has two alleles in most populations, phosphoglucomutase (PGM) has three alleles, and two leucine aminopeptidase loci have two common alleles each. Phosphoglucose isomerase displays clinial variation and an apparent association with environmental temperature. Phosphoglucomutase shows clinial variation north of Cape Cod for two of the three alleles, while the two leucine aminopeptidase loci are not clinial...
February 1981: Biochemical Genetics
J G Rhoads, J S Friedlaender
Blood genetic and antropometric data on Melanesians from Bougainville, Papus New Guinea, are analyzed by random-effects analysis of variance to partition the observed variation into components for the individuals, village, and language group level. Both clinial and unpatterned group differences exist. The differences between language groups appear to be substantial, even when the results are corrected for clinal effects. The amounts of variation of each level correspond roughly to a similar analysis of heterozygosity in blood polymorphisms...
June 1975: Proceedings of the National Academy of Sciences of the United States of America
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