Muhammad Sher, Muhammad Farooq, Uzma Abdullah, Zafar Ali, Sanam Faryal, Mohammad Zakaria, Farid Ullah, Hassan Bukhari, Rikke S Møller, Niels Tommerup, Shahid Mahmood Baig
Aim: Neuronal ceroid lipofuscinosis (NCLs) are the most common neurodegenerative disorders, with global incidence of 1 in 100,000 live births. NCLs affect central nervous system, primarily cerebellar and cerebral cortices. Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is the most common form of NCLs. JNCL is primarily caused by pathogenic mutations in CLN3 gene, which encodes a transporter transmembrane protein of uncertain function. The 1.02 kb deletion is the most common mutation in CLN3 that results in frame shift and a premature termination leading to nonfunctional protein...
September 2019: International Journal of Neuroscience