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https://www.readbyqxmd.com/read/28526636/rebamipide-ameliorates-radiation-induced-intestinal-injury-in-a-mouse-model
#1
Sehwan Shim, Hyo-Sun Jang, Hyun-Wook Myung, Jae Kyung Myung, Jin-Kyu Kang, Min-Jung Kim, Seung Bum Lee, Won-Suk Jang, Sun-Joo Lee, Young-Woo Jin, Seung-Sook Lee, Sunhoo Park
Radiation-induced enteritis is a major side effect in cancer patients undergoing abdominopelvic radiotherapy. Radiation exposure produces an uncontrolled inflammatory cascade and epithelial cell loss leading to impaired epithelial barrier function. The goal of this study was to determine the effect of rebamipide on regeneration of the intestinal epithelia after radiation injury. The abdomens of C57BL/6 mice were exposed to 13Gy of irradiation (IR) and then the mice were treated with rebamipide. Upon IR, intestinal epithelia were destroyed structurally at the microscopic level and bacterial translocation was increased...
May 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28526320/mercury-exposure-induces-cytoskeleton-disruption-and-loss-of-renal-function-through-epigenetic-modulation-of-mmp9-expression
#2
Hafizurrahman Khan, Radha Dutt Singh, Ratnakar Tiwari, Siddhartha Gangopadhyay, Somendu Kumar Roy, Dhirendra Singh, Vikas Srivastava
Mercury is one of the major heavy metal pollutants occurring in elemental, inorganic and organic forms. Due to ban on most inorganic mercury containing products, human exposure to mercury generally occurs as methylmercury (MeHg) by consumption of contaminated fish and other sea food. Animal and epidemiological studies indicate that MeHg affects neural and renal function. Our study is focused on nephrotoxic potential of MeHg. In this study, we have shown for the first time how MeHg could epigenetically modulate matrix metalloproteinase 9(MMP9) to promote nephrotoxicity using an animal model of sub chronic MeHg exposure...
May 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28523165/plasma-levels-of-matrix-metalloproteinase-9-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#3
Haiqing Li, Zhize Yuan, Sen Li, Quan Qi, Jun Liu, Mi Zhou, Junfeng Cai, Anqing Chen, Zhe Wang, Xiaofeng Ye, Qiang Zhao
BACKGROUND: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases. However, little is known about the significance of increased plasma MMP9 in patients with perioperative myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of myocardial injury during off-pump coronary artery bypass grafting (OPCAB). METHODS: A total of 34 consecutive patients with coronary artery diseases (CAD) were recruited in this prospective, observational study...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28521406/high-concentration-glucose-enhances-invasion-in-invasive-ductal-breast-carcinoma-by-promoting-glut1-mmp2-mmp9-axis-expression
#4
Xian-Fu Sun, Ying-Bo Shao, Ming-Ge Liu, Qi Chen, Zhao-Jun Liu, Bin Xu, Su-Xia Luo, Hui Liu
Type 2 diabetes mellitus (T2DM) has been considered to be a risk factor for numerous human cancers. Hyperglycemia is one of the most direct internal environmental changes for patients with T2DM. Increasing evidence reveals that a high concentration of glucose can promote tumor progression, while its role for migration and invasion of invasive ductal breast carcinoma (IDBC) cells remains unclear. In the present study, it was demonstrated that IDBC patients with T2DM suffered an increased tumor size and more frequent lymphatic and distant metastasis compared with those without T2DM (P<0...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521279/chronic-stress-impairs-the-local-immune-response-during-cutaneous-repair-in-gilthead-sea-bream-sparus-aurata-l
#5
Ana Patrícia Mateus, Liliana Anjos, João R Cardoso, Deborah M Power
Scale removal in fish triggers a damage-repair program to re-establish the lost epidermis and scale and an associated local immune response. In mammals, chronic stress is known to delay wound healing and to modulate the cutaneous stress axis, but this is unstudied in teleost fish the most successful extant vertebrates. The present study was designed to test the hypothesis that chronic stress impairs cutaneous repair in teleost fish as a consequence of suppression of the immune response. The hypothesis was tested by removing the scales and damaging the skin on one side of the body of fish previously exposed for 4 weeks to a chronic crowding stress and then evaluating cutaneous repair for 1 week...
May 15, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28521243/shikonin-alleviates-allergic-airway-remodeling-by-inhibiting-the-erk-nf-%C3%AE%C2%BAb-signaling-pathway
#6
Tian-Yue Wang, Qian-Lan Zhou, Miao Li, Yun-Xiao Shang
Shikonin is a naphthoquinone extracted from the root of Lithospermum erythrorhizon, and has been reported to suppress allergic airway inflammation in mice. However, the underlying mechanisms are unclear and need to be further elucidated. In this study, shikonin (0.5, 2 or 4mg/kg) was given intraperitoneally to ovalbumin (OVA)-challenged BALB/c mice. We found that the pathological airway remodeling of asthmatic mice was alleviated by shikonin, and the infiltrated inflammatory cells and collagen deposition in their lungs were reduced...
May 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28516393/plasma-mmp2-timp4-ratio-at-follow-up-assessment-predicts-disease-progression-of-idiopathic-pulmonary-arterial-hypertension
#7
Veronika Wetzl, Svenja Lena Tiede, Lothar Faerber, Norbert Weissmann, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Henning Gall
PURPOSE: Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are of particular interest in the remodeling processes of pulmonary hypertension. The aim of this study was to investigate MMP/TIMP ratios of selected biomarkers (MMP2, MMP9, TIMP1, TIMP4) at follow-up examination (V2) and their prognostic value in patients with idiopathic pulmonary arterial hypertension (iPAH). METHODS: Blood samples were taken from iPAH patients during right heart catheterization at diagnosis (V1, from 2003 to 2012) and first follow-up examination (V2)...
May 17, 2017: Lung
https://www.readbyqxmd.com/read/28511343/restoration-of-mir-143-expression-could-inhibit-migration-and-growth-of-mda-mb-468-cells-through-down-regulating-the-expression-of-invasion-related-factors
#8
Fatemeh Tavanafar, Reza Safaralizadeh, Mohammad Ali Hosseinpour-Feizi, Behzad Mansoori, Dariush Shanehbandi, Ali Mohammadi, Behzad Baradaran
INTRODUCTION: Breast adenocarcinoma is the second common cancer in women the incidence of which is increasing in many countries, especially in developing companies. In this study, miRNA143 has been replaced by vector based microRNA-143 in breast adenocarcinoma cells (MDA-MB-468) and its anti-cancer effects on breast adenocarcinoma cells have been evaluated. METHODS: The pCMV-MIR-143 vector was transfected into MDA-MB-468 cells via JetPEI transfection reagent. The transfected cells were selected by IC50 concentration of Geneticin antibiotic (G418) after a 2-week treatment...
May 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28508927/tumor-lxr-expression-is-a-prognostic-marker-for-patients-with-hepatocellular-carcinoma
#9
Houyong Long, Xingjun Guo, Shen Qiao, Qingxing Huang
Liver X receptor (LXR) activation exerts an anti-tumor effect. However, whether the tumor LXR expression has prognostic significance in hepatocellular carcinoma (HCC) patient has not been addressed yet. Primary HCC and the adjacent non-tumor tissues were obtained from 169 patients who underwent routine curative surgical treatment. All patients were followed for prognosis analyses. Tumor LXR was detected by immunohistochemical analysis. In in vitro study, several HCC cell lines were cultured for cellular protein detection of LXR and other cytokines, including nuclear factor kappa (NFκB), Matrix metalloproteinases 2 and 9 (MMP-2 and -9)...
May 16, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28506283/prolactin-blocks-the-expression-of-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-and-reduces-osteoclastogenesis-and-bone-loss-in-murine-inflammatory-arthritis
#10
Maria G Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp
BACKGROUND: Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone loss in AIA and in monoarticular AIA (MAIA). METHODS: Joint inflammation, trabecular bone loss, and osteoclastogenesis were evaluated in rats with AIA treated with PRL (via osmotic minipumps) and in mice with MAIA that were null (Prlr-/-) or not (Prlr+/+) for the PRL receptor...
May 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28505077/determination-of-genes-related-to-uveitis-by-utilization-of-the-random-walk-with-restart-algorithm-on-a-protein-protein-interaction-network
#11
Shiheng Lu, Yan Yan, Zhen Li, Lei Chen, Jing Yang, Yuhang Zhang, Shaopeng Wang, Lin Liu
Uveitis, defined as inflammation of the uveal tract, may cause blindness in both young and middle-aged people. Approximately 10-15% of blindness in the West is caused by uveitis. Therefore, a comprehensive investigation to determine the disease pathogenesis is urgent, as it will thus be possible to design effective treatments. Identification of the disease genes that cause uveitis is an important requirement to achieve this goal. To begin to answer this question, in this study, a computational method was proposed to identify novel uveitis-related genes...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28501767/garlic-derived-organosulfur-compound-exerts-antitumor-efficacy-via-activation-of-mapk-pathway-and-modulation-of-cytokines-in-sgc-7901-tumor-bearing-mice
#12
Xiaoyan Jiang, Xiaosong Zhu, Weizhen Huang, Hongya Xu, Zhongxi Zhao, Siying Li, Shanzhong Li, Jianhua Cai, Jimin Cao
Diallyl trisulfide (DATS), a natural agent derived from garlic, has been tested for its antigastric cancer activities in various preliminary studies. However, more systematic pharmacodymatic (PD) and mechanistic evaluations are clearly needed. The aim of this study was to investigate the antitumor effects of DATS in the treatment of human gastric cancer cell SGC-7901 both in vitro and in vivo using widely recommended study procedures. DATS suppressed cancer cells proliferation and induced cell cycle arrest accompanied by an increase in the expressions of cyclin A2 and cyclin B1 in SGC-7901 cancer cells...
May 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28501009/mir-205-as-a-biological-marker-in-non-small-cell-lung-cancer
#13
Baoqi Duan, Tao Guo, Haoliang Sun, Rui Cai, Qinglin Rui, Zhaoqing Xi
OBJECTION: The aim of this study is to explain the significance and mechanism of miR-205 in the diagnosis and treatment of non-small cell lung cancer. METHODS: The 70 advanced NSCLC patients, treated in our hospital, were collected from 2011.10 to 2013.9, taking the tissues from cancer and adjacent tissues to measure the miR-205 expression, evaluate the AKT gene and protein expression of cancer and adjacent normal tissues by RT-PCR and Immunohistochemistry (IHC) assays and analyzing the correlation between miR-205 and AKT...
May 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28500450/genetic-variation-in-matrix-metalloproteinase-mmp2-and-mmp9-as-a-risk-factor-for-idiopathic-recurrent-spontaneous-abortions-in-an-indian-population
#14
Deepika Ramu, Vettriselvi Venkatesan, Solomon Franklin Durairaj Paul, Teena Koshy
PURPOSE: Matrix metalloproteinases, MMP2 and MMP9, are found to have an important role during ovulation and pregnancy because of their capacity to degrade components of the extracellular matrix (ECM) thereby facilitating cell migration and angiogenesis. In this respect, the aim of the present study was to evaluate the association of the promoter polymorphisms -1306 C > T and -1562 C/T in MMP2 and MMP9 respectively with couples diagnosed with idiopathic recurrent spontaneous abortions (IRSA)...
May 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28498893/role-of-dhx33-in-c-myc-induced-cancers
#15
Jijun Fu, Yuchu Liu, Xingshun Wang, Baolei Yuan, Yandong Zhang
Oncogene c-Myc is frequently amplified and activated in human cancers. Deregulation of c-Myc protein has been shown to occur in 30% of all human cancers, especially in hematopoietic malignancies. As a transcription factor, c-Myc has been shown to regulate up to 15% of all human genome genes, controlling diverse cellular activities including cell cycle, ribosome biogenesis, protein synthesis, metabolism, apoptosis and angiogenesis. In this report, we provide evidence that the RNA helicase DHX33 is a critical downstream target of c-Myc...
May 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28498635/snx10-plays-a-critical-role-in-mmp9-secretion-via-jnk-p38-erk-signaling-pathway
#16
Chun Zhou, Ying Wang, Jin Peng, Cuixian Li, Peiqing Liu, Xiaoyan Shen
Matrix metalloproteinases (MMPs) plays a critical role in the degradation of extracellular matrix (ECM). Sorting nexin (SNX) 10 is a member of the SNX family, which functions in regulation of endosomal sorting and osteoclast activation, has been implicated to play an important role in the bone erosion of rheumatoid arthritis. In this study, we aimed to investigate the possible role of SNX10 on MMP9 secretion and the potential mechanism. By immunostaining and co-immunoprecipitation, we found that SNX10 was extensively co-localized with MMP9, indicating that SNX10 might participate in MMP9 trafficking...
May 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28494022/the-effect-of-biological-sealants-and-adhesive-treatments-on-matrix-metalloproteinase-expression-during-renal-injury-healing
#17
José Miguel Lloris-Carsí, Carlos Barrios, Beatriz Prieto-Moure, José Miguel Lloris-Cejalvo, Dolores Cejalvo-Lapeña
BACKGROUND: Renal injuries are relatively common in cases of abdominal trauma. Adhesives and sealants can be used to repair and preserve damaged organs. Using a rat model, this study explores the activity of different matrix metalloproteinases (MMP) during the healing of renal injuries treated by two biological adhesives (TachoSil and GelitaSpon) and a new synthetic elastic cyanoacrylate (Adhflex). METHODS: Renal traumatic injuries were experimentally induced in 90 male Wistar rats by a Stiefel Biopsy Punch in the anterior aspect of the left kidney...
2017: PloS One
https://www.readbyqxmd.com/read/28492136/inhibition-of-erk1-2-signaling-impairs-the-promoting-effects-of-tgf-%C3%A3-1-on-hepatocellular-carcinoma-cell-invasion-and-epithelial-mesenchymal-transition
#18
Ling Liu, Nianfeng Li, Qi Zhang, Jixiang Zhou, Ling Lin, Xinxin He
TGF-ß and ERK signaling have been implicated in various human cancers including hepatocellular carcinoma, but the underlying mechanism remains largely unclear. In this study, we aimed to explore the role of ERK1/2 in the regulation of TGF-ß's promoting and suppressive activities in HCC cells. Our data showed that treatment with TGF-ß1 enhanced invasion and epithelial-mesenchymal transition (EMT) in HCC HepG2 cells, accompanied with increased MMP9 production and activation of Smad2/3 and ERK1/2, but inhibited tumor cell proliferation...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28490769/increased-cerebral-expressions-of-mmps-cldn5-ocln-zo1-and-aqps-are-associated-with-brain-edema-following-fatal-heat-stroke
#19
Yu Du, Jing-Tao Xu, Hong-Nian Jin, Rui Zhao, Dong Zhao, Si-Hao Du, Ye Xue, Xiao-Li Xie, Qi Wang
Human brain samples were collected from 46 autopsy cases, including 23 fatal heat stroke cases and 23 age-matched controls. Nine candidate reference genes (PES1, POLR2A, IPO8, HMBS, SDHA, GAPDH, UBC, B2M, ACTB) were evaluated in the cerebral cortex of 10 forensic autopsy cases (5 heat stroke and 5 controls), using the geNorm module in qBase(plus) software. SDHA, POLR2A, IPO8 and HMBS were identified as the most stable reference genes. Using these validated reference genes, mRNA expressions of Matrix metalloproteinases (MMPs, MMP2 and MMP9), Claudin5 (CLDN5), Occludin (OCLN), Zona occludens protein-1 (ZO1) and Aquaporins (AQPs, AQP1 and AQP4) in the cerebral cortex were examined...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28488764/astrocytes-contribute-to-a%C3%AE-induced-blood-brain-barrier-damage-through-activation-of-endothelial-mmp9
#20
Simona Federica Spampinato, Sara Merlo, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
The blood brain barrier (BBB) plays an important role in the maintenance of the brain homeostasis, and its proper functions are warranted by the interplay between different cellular components (endothelial cells, astrocytes and pericytes). BBB dysfunctions in pathological conditions, and in particular in Alzheimer's disease, have been documented. Here, using an in vitro BBB model, the interaction between endothelial cells and astrocytes exposed to Aβ1-42 was investigated. Human endothelial cells, cultured in monolayer or co-cultured with astrocytes, were exposed to Aβ1-42 (2 μM for 18 hours)...
May 10, 2017: Journal of Neurochemistry
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