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Ming-Yue Sun, Miao Zhang, Shui-Ling Chen, Shu-Ping Zhang, Chun-Yu Guo, Jing-Shang Wang, Xin Liu, Yang Miao, Hui-Jun Yin
BACKGROUND/AIMS: Systemic iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including AS (Atherosclerosis). The hepcidin-ferroportin axis plays the key role in regulation of iron homeostasis and modulation of this signaling could be a potential therapeutic strategy in the treatment of these diseases. TMP (Tetramethylpyrazine) has been reported to have therapeutical effect on AS...
May 9, 2018: Cellular Physiology and Biochemistry
Benny Davidovitch, Dominic Vella
We consider the equilibrium of liquid droplets sitting on thin elastic sheets that are subject to a boundary tension and/or are clamped at their edge. We use scaling arguments, together with a detailed analysis based on the Föppl-von-Kármán equations, to show that the presence of the droplet may significantly alter the stress locally if the tension in the dry sheet is weak compared to an intrinsic elasto-capillary tension scale γ2/3(Et)1/3 (with γ the droplet surface tension, t the sheet thickness and E its Young modulus)...
May 15, 2018: Soft Matter
John C Huetsch, Jasmine Walker, Clark Undem, Julie Lade, Xin Yun, Syeda Baksh, Haiyang Jiang, Ning Lai, Larissa A Shimoda
Excessive production of endothelin-1 (ET-1) has been observed in almost all forms of pulmonary hypertension. ET-1, a highly potent vasoconstrictor, can also potentiate pulmonary arterial smooth muscle cell (PASMC) growth and migration, both of which contribute to the vascular remodeling that occurs during the development of pulmonary hypertension. Increasing evidence indicates that alkalinization of intracellular pH (pHi ), typically due to activation of Na+ /H+ exchange (NHE), is associated with enhanced PASMC proliferation and migration...
May 2018: Physiological Reports
Matthew Strider Jeffers, Dale Corbett
BACKGROUND AND PURPOSE: Reach training in concert with environmental enrichment provides functional benefits after experimental stroke in rats. The present study extended these findings by assessing whether intensive task-specific reach training or enrichment initiated alone would provide similar functional benefit. Additionally, we investigated whether the 70% recovery rule, or a combined model of initial poststroke impairment, cortical infarct volume, and rehabilitation intensity, could predict recovery in the single-pellet task, as previously found for the Montoya staircase...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
Hong Liu, Li-Ping Tan, Xin Huang, Yi-Qiu Liao, Wei-Jian Zhang, Pei-Bo Li, Yong-Gang Wang, Wei Peng, Zhong Wu, Wei-Wei Su, Hong-Liang Yao
Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3- O -α-l-glucoside, 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Quercetin isomers, and 3- O -{2- O -{6- O -[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Kaempferide...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ching-Chia Wang, Lihua Ying, Elizabeth A Barnes, Eloa S Adams, Francis Y Kim, Karl W Engel, Cristina M Alvira, David N Cornfield
Pulmonary artery smooth muscle cells (PASMC) express endothelin (ET-1) which modulates the pulmonary vascular response to hypoxia. Although cross-talk between hypoxia-inducible factor-1α (HIF-1α), an O2 -sensitive transcription factor, and ET-1 is established, the cell-specific relationship between HIF-1α and ET-1 expression remains incompletely understood. We tested the hypotheses that in PASMC: (i) HIF-1α expression constrains ET-1 expression; and (ii) a specific microRNA (miRNA) links HIF-1α and ET-1 expression...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
Yu-Hsuan Li, Wayne Huey-Herng Sheu, Wen-Jane Lee, Jun -Sing Wang, Chia-Po Fu, Kae-Woei Liang, I-Te Lee
Endothelin-1 (ET-1) is associated with endothelial dysfunction and vasoconstriction. Increased circulating ET-1 levels are associated with long-term cardiovascular mortality. Renalase, released from kidney, metabolizes catecholamines and regulates blood pressure. An increase in circulating renalase levels has been reported in patients with chronic kidney disease (CKD) and is associated with coronary artery disease (CAD). We hypothesized the existence of a synergistic effect of serum renalase levels and CKD on ET-1 levels in patients with CAD...
May 9, 2018: Scientific Reports
Michał Wiciński, Katarzyna Szadujkis-Szadurska, Mateusz M Węclewicz, Bartosz Malinowski, Grzegorz Matusiak, Maciej Walczak, Eryk Wódkiewicz, Grzegorz Grześk, Katarzyna Pawlak-Osińska
Endothelin-1 (ET-1) is one of the key factors regulating tension of smooth muscles in blood vessels. It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress. The main objective of this paper was to evaluate the role of Rho-kinase in the ET-1-induced constriction of arteries. The analysis also included significance of intra- and extracellular pool of calcium ions in constriction triggered by ET-1...
May 5, 2018: Microvascular Research
Wen-Lin Hsu, Yu-Chieh Lin, Jing-Ren Jeng, Heng-Yuan Chang, Tz-Chong Chou
Baicalein (BE) extracted from Scutellaria baicalensis Georgi is able to alleviate various cardiovascular and inflammatory diseases. However, the effects of BE on pulmonary arterial hypertension (PAH) remain unknown. Therefore, the present study aimed to examine whether BE ameliorates pneumonectomy and monocrotaline-induced PAH in rats and further investigate the underlying molecular mechanisms. Administration of BE greatly attenuated the development of PAH as evidenced by an improvement of its characteristic features, including elevation of right ventricular systolic pressure, right ventricular hypertrophy, and pulmonary vascular remodeling...
May 8, 2018: American Journal of Chinese Medicine
Tsutomu Hoshino, Ikki Kaneko, Yuri Terasawa
Squalene-hopene cyclase (SHC) catalyzes the conversion of squalene 1 into 6,6,6,6,5-fused pentacyclic hopene 2 and hopanol 3. To elucidate the binding sites for the terminal positions of 1, four analogs, having the larger ethyl (Et) and the hydrophilic CH2OH groups at 23E or 23Z-positions of 1, were incubated with SHC. The analog having the Et group at the 23E-position (23E-Et-1), yielded two tetra- and three pentacyclic products; however, the analog possessing the Et group at the 23Z-position (23Z-Et-1) gave two hopene homologs and the neohopane skeleton, but no hopanol homologs...
May 6, 2018: Chemistry: a European Journal
Andrea Di Cristofori, Massimiliano Del Bene, Marco Locatelli, Francesca Boggio, Giulia Ercoli, Stefano Ferrero, Alessandro Del Gobbo
OBJECTIVE: Several hypothesis have been proposed in order to understand the mechanisms underlying the meningioma related hyperostosis. Objective of our study was to investigate the role of osteoprotegerin(OPG), insulin-like growth factor-1(IGF-1), endothelin-1(ET-1), Bone Morphogenetic Protein(BMP-2 and -4). METHODS: A total of 149 patients (39 males and 110 females with a mean age of 62 years) that received surgery were included. Depending on the relationship with the bone, meningiomas were classified in hyperostotic, osteolytic, infiltrative and without relation with the bone...
May 2, 2018: World Neurosurgery
Galyna V Yeryomenko
OBJECTIVE: Introduction: the purpose of the research consisted in the study of the functional state of the endothelium in patients having persistent asthma (A) with an uncontrolled course in combination with diabetes mellitus type 2 (DM2T) and obesity (O) The aim: on the basis of a complex study of nitric oxide metabolites (nitrosothiols, S-NO), von Willebrand factor (VWF) and endothelin-1 (EТ-1). PATIENTS AND METHODS: Materials and methods: The study involved 90 A patients with comorbid states, who were divided into 3 groups...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Qiang Wan, Zhongyong Liu, Yuping Yang
BACKGROUND: Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media into the intima is a crucial step in the pathophysiology of atherosclerosis. Puerarin, a natural extract from Radix Puerariae, possesses significant anti-atherosclerosis properties. However, the underlying molecular mechanisms responsible for the effect of puerarin on the VSMCs proliferation induced by PM2...
May 4, 2018: BMC Complementary and Alternative Medicine
Kazuhide Koike, David C Grills, Yusuke Tamaki, Etsuko Fujita, Kei Okubo, Yasuomi Yamazaki, Masaki Saigo, Tatsuhiko Mukuta, Ken Onda, Osamu Ishitani
Supramolecular photocatalysts in which Ru(ii) photosensitizer and Re(i) catalyst units are connected to each other by an ethylene linker are among the best known, most effective and durable photocatalytic systems for CO2 reduction. In this paper we report, for the first time, time-resolved infrared (TRIR) spectra of three of these binuclear complexes to uncover why the catalysts function so efficiently. Selective excitation of the Ru unit with a 532 nm laser pulse induces slow intramolecular electron transfer from the 3 MLCT excited state of the Ru unit to the Re unit, with rate constants of (1...
March 21, 2018: Chemical Science
Bing-Yang Zhou, Xiong-Yi Gao, Xi Zhao, Ping Qing, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ying Gao, Geng Liu, Qian Dong, Jian-Jun Li
AIM: The predictive value of big endothelin-1 (ET-1) for cardiovascular outcomes in myocardial infarction (MI) patients younger than 35 years old has not been characterized. METHODS: A total of 565 consecutive MI patients younger than 35 years old were studied and followed up for 37.78 ± 24.9 months. RESULTS: Multivariable Cox regression analysis showed that big ET-1 was positively correlated with major adverse cardiovascular events [MACEs] (odds ratio: 3; 95% CI: 1...
January 2018: Personalized Medicine
Shuai Zhao, Yong Tang, Hairong Cai, Weifeng Liu, Lieyuan Zhang, Dongjie Chen, Bojun Chen
Objective: This double-blind and randomized placebo-controlled trial evaluated the safety and efficacy of Danhong injection combined with Naoxintong capsule in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: ACS patients scheduled to undergo PCI ( n = 130) were equally and randomly apportioned to either a treatment or control group. After PCI, the treatment group received Danhong injection combined with Naoxintong capsule for 12 weeks, while the control group was given placebo...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Lei Zhou, Hongfang Cai
OBJECTIVE: To observe the effects of acupoint catgut embedding assisting western medication and simple western medication on blood pressure and vascular endothelial function in patients with essential hypertension (EH), and to explore its mechanism. METHODS: A total of 125 cases were randomly assigned into an observation group (62 cases, 2 dropping) and a control group (63 cases, 3 dropping). Oral administration of lotensin (10 mg, once a day) was applied in the control group...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Tian-Yi Yuan, Zi-Ran Niu, Di Chen, Yu-Cai Chen, Hui-Fang Zhang, Lian-Hua Fang, Guan-Hua Du
The aim of this study is to investigate the vasorelaxant effect of quercetin on cerebral basilar artery in vitro and provide a preliminary discussion concerning the underlying mechanisms. Using a DMT-isolated micro vessel system, quercetin was found to exhibit a vasodilatory effect on basilar arteries contracted by potassium chloride (KCl), endothelin-1 (ET-1), and 5-hydroxytryptamine (5-HT). The vasorelaxant effect of quercetin was partially attenuated when endothelium cells were removed. L-NAME, indomethacin, and ODQ treatment also decreased the potency of quercetin...
April 25, 2018: Journal of Asian Natural Products Research
Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C Bergmann
BACKGROUND: Tumor necrosis factor (TNF) is associated with several neurodegenerative disorders including multiple sclerosis (MS). Although TNF-targeted therapies have been largely unsuccessful in MS, recent preclinical data suggests selective soluble TNF inhibition can promote remyelination. This has renewed interest in regulation of TNF signaling in demyelinating disease, especially given the limited treatment options for progressive MS. Using a mouse model of progressive MS, this study evaluates the effects of sustained TNF on oligodendrocyte (OLG) apoptosis and OLG precursor cell (OPC) differentiation...
April 24, 2018: Journal of Neuroinflammation
C-J Zhang, Y-Z Deng, Y-H Lei, J-B Zhao, W Wei, Y-H Li
OBJECTIVE: To investigate the mechanism of exogenous adiponectin in the prevention of no-reflow phenomenon in type 2 diabetic (T2DM) patients with acute myocardial infarction (AMI) during percutaneous coronary intervention (PCI) treatment. PATIENTS AND METHODS: 66 patients were randomly divided into control group and observation group, 33 cases in each group. According to the percutaneous coronary intervention (PCI) emergency treatment principle, patients from the control group were treated with an intracoronary injection of adenosine combined with a micro-pump intravenous infusion of tirofiban...
April 2018: European Review for Medical and Pharmacological Sciences
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