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https://www.readbyqxmd.com/read/28214885/signaling-pathway-for-endothelin-1-and-phenylephrine-induced-camp-response-element-binding-protein-activation-in-rat-ventricular-myocytes-role-of-inositol-1-4-5-trisphosphate-receptors-and-camkii
#1
Krishna P Subedi, Min-Jeong Son, Bojjibabu Chidipi, Seong-Woo Kim, Jun Wang, Kyeong-Hee Kim, Sun-Hee Woo, Joon-Chul Kim
BACKGROUND/AIMS: Endothelin-1 (ET-1) and the α<Sub>1</Sub>-adrenoceptor agonist phenylephrine (PE) activate cAMP response element binding protein (CREB), a transcription factor implicated in cardiac hypertrophy. The signaling pathway involved in CREB activation by these hypertrophic stimuli is poorly understood. We examined signaling pathways for ET-1- or PE-induced cardiac CREB activation. METHODS: Western blotting was performed with pharmacological and genetic interventions in rat ventricular myocytes...
January 26, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28183819/a-chronic-physical-activity-treatment-in-obese-rats-normalizes-the-contributions-of-et-1-and-no-to-insulin-mediated-posterior-cerebral-artery-vasodilation
#2
T Dylan Olver, Matthew W McDonald, Diana Klakotskaia, Rachel A Richardson, Jeffrey L Jasperse, C W James Melling, Todd R Schachtman, Hsiao T Yang, Craig A Emter, M Harold Laughlin
This study tested the hypotheses that obesity-induced decrements in insulin-stimulated cerebrovascular vasodilation would be normalized with acute endothelin-1a receptor antagonism, and treatment with a physical activity intervention restores vasoreactivity to insulin through augmented nitric oxide synthase (NOS)-dependent dilation. Otsuka Long-Evans Tokushima Fatty rats were divided into the following groups; 20-wk old food-controlled (CON-20); 20-wk old free-food access (model of obesity, OB-20); 40-wk old food-controlled (CON-40); 40-wk old free-food access (OB-40); and 40-wk old free-food access+RUN (RUN-40; wheel-running access from 20-40 wk)...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28181422/hmgb1-contributes-to-glomerular-endothelial-cell-injury-in-anca-associated-vasculitis-through-enhancing-endothelium-neutrophil-interactions
#3
Chen Wang, Dong-Yuan Chang, Min Chen, Ming-Hui Zhao
Our previous studies demonstrated that high mobility group box-1 (HMGB1), a typical damage-associated molecular pattern (DAMP) protein, is associated with the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Moreover, HMGB1 participates in ANCA-induced neutrophil activation. The current study aimed to investigate whether HMGB1 regulated the interaction between neutrophils and glomerular endothelial cells (GEnC) in the presence of ANCA. Correlation analysis on HMGB1 levels in AAV patients and soluble intercellular cell adhesion molecule-1 (sICAM-1) levels or vascular endothelial growth factor (VEGF) levels, which are markers of endothelial cell activation, was performed...
February 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28181133/effects-of-aerobic-exercise-training-on-metabolism-of-nitric-oxide-and-endothelin-1-in-lung-parenchyma-of-rats-with-pulmonary-arterial-hypertension
#4
A Zimmer, R B Teixeira, J H P Bonetto, R Siqueira, C C Carraro, L M Donatti, A Hickmann, I E Litvin, A E G Godoy, A S Araujo, R Colombo, Adriane Belló-Klein
Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and proliferative obstruction of pulmonary vessels, which promotes a progressive increase in pulmonary vascular resistance (PVR). The effect of exercise training on oxidative stress, metabolism, and markers of nitric oxide (NO) and endothelin-1 (ET-1) was analyzed in the lung tissue of rats with PAH induced by monocrotaline (MCT).Twenty-four Wistar rats were divided into four groups (5-7 animals): sedentary control (SC), sedentary MCT (SM), trained control (TC), and trained MCT (TM)...
February 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28179472/endothelin-confers-protection-against-high-glucose-induced-neurotoxicity-via-alleviation-of-oxidative-stress
#5
Mohamed Fouda, Abdel A Abdel-Rahman
Recent findings linked the inhibition in the neuromodulator peptide endothelin-1 (ET-1) level to the high glucose-evoked neurotoxicity. However, definitive neuroprotective role for ET-1, and the major neuronal ET (ET-3), against high glucose-evoked toxicity, and the implicated neurochemical responses triggered by their ET-A and ET-B receptors remain unknown. Here, we tested the hypothesis that ET-B activation alleviates high glucose-evoked oxidative stress and cell death. High glucose (100 mM for 48 hrs.)-evoked cell death was associated with elevation in reactive oxygen species, inhibition of catalase activity, and a paradoxical upregulation of hemeoxygenase-1 expression along with ET-A and ET-B receptors were down-regulated and up-regulated, respectively...
February 8, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28178968/imatinib-relaxes-the-pulmonary-venous-bed-of-guinea-pigs
#6
Nina A Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin, Annette D Rieg
BACKGROUND: Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-derived growth factor (PDGF)-receptor (PDGFR), acts antiproliferative and relaxes pulmonary arteries. However so far, the relaxant effects of imatinib on pulmonary veins (PVs) and on the postcapillary resistance are unknown, although pulmonary hypertension (PH) due to left heart disease (LHD) is most common and primarily affects PVs...
February 8, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28174289/vascular-effects-of-obestatin-in-lean-and-obese-subjects
#7
Francesca Schinzari, Augusto Veneziani, Nadia Mores, Angela Barini, Nicola Di Daniele, Carmine Cardillo, Manfredi Tesauro
Obese patients have impaired vasodilator reactivity and increased endothelin (ET)-1-mediated vasoconstriction, two abnormalities contributing to vascular dysfunction. Obestatin, a product of the ghrelin gene, in addition to favorable effects on glucose and lipid metabolism, has shown nitric oxide (NO)-dependent vasodilator properties in experimental models. Given these premises, we compared the effects of exogenous obestatin on forearm flow in lean and obese subjects and assessed its influence on ET-1-dependent vasoconstrictor tone in obesity...
February 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28153500/endothelin-causes-transactivation-of-the-egfr-and-her2-in-non-small-cell-lung-cancer-cells
#8
Terry W Moody, Irene Ramos-Alvarez, Paola Moreno Perez, Samuel A Mantey, Lisa Ridnour, David Wink, Robert T Jensen
Endothelin (ET)-1 is an important peptide in cancer progression stimulating cellular proliferation, tumor angiogenesis and metastasis. ET-1 binds with high affinity to the ETA receptor (R) and ETBR on cancer cells. High levels of tumor ET-1 and ETAR are associated with poor survival of lung cancer patients. Here the effects of ET-1 on epidermal growth factor (EGF)R and HER2 transactivation were investigated using non-small cell lung cancer (NSCLC) cells. ETAR mRNA was present in all 10 NSCLC cell lines examined...
January 30, 2017: Peptides
https://www.readbyqxmd.com/read/28141700/endothelial-and-perivascular-adipose-tissue-abnormalities-in-obesity-related-vascular-dysfunction-novel-targets-for-treatment
#9
Francesca Schinzari, Manfredi Tesauro, Carmine Cardillo
The heavy impact of obesity on the development and progression of cardiovascular disease has sparked sustained efforts to uncover the mechanisms linking excess adiposity to vascular dysfunction. In addition to its well-established role in maintaining vascular homeostasis, the endothelium has been increasingly recognized as a key player in modulating healthy adipose tissue expansion in response to excess calories by providing adipocyte precursors and driving angiogenesis. When this increased storage need is unmet, excessive deposition of fat occurs at ectopic locations, including perivascular adipose tissue (PVAT)...
January 30, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28139522/ovarian-fibrosis-a-phenomenon-of-concern
#10
REVIEW
Feng Zhou, Li-Bing Shi, Song-Ying Zhang
OBJECTIVE: Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts and deposition of extracellular matrix (ECM) and it is one of the principal reasons for ovarian dysfunction. This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis. DATA SOURCES: We searched PubMed for English language articles published up to November 2016. The search terms included ovarian fibrosis OR fibrosis, ovarian chocolate cyst OR ovarian endometrioma, polycystic ovarian syndrome (PCOS), premature ovarian failure, ECM, matrix metalloproteinases (MMPs), tissue inhibitors of matrix metalloproteinases (TIMPs), transforming growth factor-beta 1 (TGF-β1), connective tissue growth factor (CTGF), peroxisome proliferator-activated receptor gamma (PPAR-γ), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and combinations of these terms...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28134077/dual-endothelin-receptor-antagonists-contrast-the-effects-induced-by-endothelin-1-on-cultured-human-microvascular-endothelial-cells
#11
Stefano Soldano, Sabrina Paolino, Carmen Pizzorni, Amelia Chiara Trombetta, Paola Montagna, Renata Brizzolara, Claudio Corallo, Nicola Giordano, Alberto Sulli, Maurizio Cutolo
OBJECTIVES: To evaluate the ability of dual endothelin (ET) receptor antagonists (ETA/ETB -ETA/BRAs) to contrast the ET-1-induced effects on cultured human microvascular endothelial cells (HMVECs). METHODS: Some cultured HMVECs were untreated, or treated with ET-1 (100nM) or transforming growth factor β1 (TGFβ1, 10ng/mL) alone for 6 days, in order to induce the endothelial-to-mesenchymal transition (EndoMT). Other cultured HMVECs were pre-treated for 1hr with ETA/BRAs bosentan (10μM) or macitentan (1μM, 10μM) before the stimulation with ET-1 for 6 days...
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28128745/endothelial-dysfunction-microvascular-damage-and-ischemic-peripheral-vasculopathy-in-systemic-sclerosis
#12
Ivone Fernandes Santos da Silva, Andreia Teixeira, José Oliveira, Rui Almeida, Carlos Vasconcelos
OBJECTIVE: To evaluate endothelial dysfunction and microvascular damage in secondary Raynaud Phenomenon (SRP) and Systemic sclerosis (SSc)-associated patients as possible predictors of ischemic fingertip digital ulcers (DU) in a 3-year clinical follow-up. METHODS: Flow-mediated dilatation (FMD), nailfold videocapillaroscopy (NVC), endothelin-1 (ET-1) and asymmetric dimethylarginine (ADMA) were analysed in a 3-year observational cohort study of 77 SRP patients with systemic sclerosis...
January 27, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28123710/effects-of-propofol-on-myocardial-ischemia-reperfusion-injury-in-rats-with-type-2-diabetes-mellitus
#13
Ying Wang, Xiuru Qi, Chunliang Wang, Danning Zhao, Hongjie Wang, Jianxin Zhang
The current study aimed to examine the effects of propofol on myocardial ischemia-reperfusion injury (MIRI) in rats with type-2 diabetes mellitus (T2DM) and to assess the role of inflammatory mediators. Fifty healthy male adult Sprague-Dawley rats were randomly divided into the sham, ischemia-reperfusion (IR), IR plus low, middle and high-dose (6, 12 and 24 mg/kg/h, intravenous) propofol groups. The rats of all the groups were fed a high-sugar and high-fat diet for 8 weeks and streptozotocin (30 mg/kg, intraperitoneally) was used to establish the T2DM model...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28123464/effect-of-a-small-dose-of-aspirin-on-quantitative-test-of-24-h-urinary-protein-in-patients-with-hypertension-in-pregnancy
#14
Fangmei Liu, Huili Yang, Guiyun Li, Kun Zou, Yana Chen
The aim of the present study was to determine the effect of a small dose of aspirin on a quantitative test of 24-h urinary protein in patients with hypertension in pregnancy. In total, 224 patients with hypertension in pregnancy were continuously selected and were randomly divided into the control group (50 cases with conventional therapy), aspirin 50 mg/day group (60 cases), aspirin 75 mg/day group (58 cases), and aspirin 100 mg/day group (56 cases). Clinical effects were compared from 16 gestational weeks to childbirth...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28122355/plumbagin-restrains-hepatocellular-carcinoma-angiogenesis-by-suppressing-the-migration-and-invasion-of-tumor-derived-vascular-endothelial-cells
#15
YanFei Wei, Qi Yang, Yuan Zhang, TieJian Zhao, XueMei Liu, Jing Zhong, Jing Ma, YongXin Chen, Chuan Zhao, JunXuan Li
Tumor occurrence and development are very complicated processes. In addition to the roles of exogenous carcinogenic factors, the body's internal factors also play important roles. These factors include the host response to the tumor and the tumor effect on the host. In particular, the proliferation, migration and activation of endothelial cells are involved in tumor angiogenesis. Angiogenesis is one of the hallmarks of cancer. In this study, we investigate whether plumbagin can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and, if so, through which molecular mechanisms...
January 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28120456/endothelin-1-mediates-natriuresis-but-not-polyuria-during-vitamin-d-induced-acute-hypercalcemia
#16
Natsuko Tokonami, Lydie Cheval, Isabelle Monnay, Guillaume Meurice, Johaness Loffing, Eric Feraille, Pascal Houillier
Acute hypercalcemia increases urinary sodium and water excretion; however, the underlying molecular mechanism remains unclear. As vitamin D-induced hypercalcemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcemia on renal sodium and water handling. Hypercalcemia was induced in 8 week-old, PTH-supplemented, male mice by oral administration of dihydrotachysterol (DHT) for 3 days. DHT-treated mice became hypercalcemic and displayed increased urinary water and sodium excretion compared to controls...
January 24, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28116728/isolation-and-culture-of-endothelial-cells-from-large-vessels
#17
Augusto C Montezano, Karla B Neves, Rheure A M Lopes, Francisco Rios
The endothelium, which is at the interface between circulating blood and the vascular wall, comprises a simple squamous layer of cells that lines the inner surface of all blood vessels. Endothelial cells are highly metabolically active and play an important role in many physiological functions, including control of vasomotor tone, blood cell trafficking, vascular permeability, and maintenance of vascular integrity (Mensah, Vascul Pharmacol 46(5):310-314, 2007; Yetik-Anacak and Catravas, Vascul Pharmacol 45(5):268-276, 2006)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28115138/endocannabinoid-2-arachidonoylglycerol-protects-inflammatory-insults-from-sulfur-dioxide-inhalation-via-cannabinoid-receptors-in-the-brain
#18
Ben Li, Minjun Chen, Lin Guo, Yang Yun, Guangke Li, Nan Sang
Sulfur dioxide (SO2) pollution in the atmospheric environment causes brain inflammatory insult and inflammatory-related microvasculature dysfunction. However, there are currently no effective medications targeting the harmful outcomes from chemical inhalation. Endocannabinoids (eCBs) are involved in neuronal protection against inflammation-induced neuronal injury. The 2-arachidonoylglycerol (2-AG), the most abundant eCBs and a full agonist for cannabinoid receptors (CB1 and CB2), is also capable of suppressing proinflammatory stimuli and improving microvasculature dysfunction...
January 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28101177/analysis-on-mechanism-of-atp-sensitive-k-channel-opener-natakalim-improving-congestive-heart-failure-after-myocardial-infarction
#19
Feng Jin
The action mechanism of natakalim, a novel ATP-sensitive potassium channel opener, was studied in ameliorating the congestive heart failure (CHF) after myocardial infarction. A total of 25 healthy Wistar male rats (age, 10 weeks; average weight, 300 g) were selected, and the CHF models after acute myocardial infarction (AMI) were prepared by ligation of left anterior descending branch. They were randomly divided into the sham operation group, the model group and the groups of 1, 3 and 9 mg/kg/day natakalims...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100330/-protective-effects-of-heat-shock-protein-70-against-hypoxic-pulmonary-hypertension-in-neonatal-rats
#20
Le Wang, Hai-Yan Wu, Ming-Xia Li
OBJECTIVE: To investigate the protective effect of heat shock protein 70 (HSP70) against hypoxic pulmonary hypertension (HPH) in neonatal rats. METHODS: A total of 128 neonatal rats were randomly divided into blank control group, HPH model group, empty virus group, and HSP70 group, with 32 rats in each group. Before the establishment of an HPH model, the rats in the blank control group and HPH model group were given caudal vein injection of 5 μL sterile saline, those in the empty virus group were given caudal vein injection of 5 μL Ad-GFP (1 010 PFU/mL), and those in the HSP70 group were given caudal vein injection of 5 μL Ad-HSP70 (1 010 PFU/mL)...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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